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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:roxarsone
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Accession:CHEBI:35817 term browser browse the term
Definition:An organoarsonic acid where the organyl group is 4-hydroxy-3-nitrophenyl.
Synonyms:exact_synonym: (4-hydroxy-3-nitrophenyl)arsonic acid
 related_synonym: 2-nitro-1-hydroxybenzene-4-arsonic acid;   3-Nitro;   3-nitro-4-hydroxybenzenearsonic acid;   3-nitro-4-hydroxyphenylarsonic acid;   4-hydroxy-3-nitrobenzenearsonic acid;   4-hydroxy-3-nitrophenylarsonic acid;   Formula=C6H6AsNO6;   InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12);   InChIKey=XMVJITFPVVRMHC-UHFFFAOYSA-N;   NSC-2101;   Ren-O-Sal;   SMILES=Oc1ccc(cc1[N+]([O-])=O)[As](O)(O)=O;   roxarson;   roxarsonum
 xref: Beilstein:1976533;   CAS:121-19-7;   Gmelin:1221211;   LINCS:LSM-5383
 xref_mesh: MESH:D012406
 xref: PMID:12724787;   PMID:12731831;   PMID:12731832;   PMID:18414637;   PMID:21388897;   Patent:DE224953;   Patent:GB226255;   Reaxys:1976533;   VSDB:3003;   Wikipedia:Roxarsone


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roxarsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT1 angiopoietin 1 decreases expression EXP Roxarsone results in decreased expression of ANGPT1 mRNA CTD PMID:18414637 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055 		JBrowse link
G CNMD chondromodulin decreases expression EXP Roxarsone results in decreased expression of CNMD mRNA CTD PMID:18414637 NCBI chr13:52,703,264...52,739,820
Ensembl chr13:52,703,264...52,739,820 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 decreases expression EXP Roxarsone results in decreased expression of CXCL9 mRNA CTD PMID:18414637 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509 		JBrowse link
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases secretion EXP Roxarsone results in increased secretion of ENPP2 protein CTD PMID:22952646 NCBI chr 8:119,557,086...119,673,390
Ensembl chr 8:119,557,086...119,673,453 		JBrowse link
G FHDC1 FH2 domain containing 1 decreases expression EXP Roxarsone results in decreased expression of INF1 mRNA CTD PMID:18414637 NCBI chr 4:152,911,339...152,979,671
Ensembl chr 4:152,936,323...152,979,671 		JBrowse link
G HGF hepatocyte growth factor increases expression EXP Roxarsone results in increased expression of HGF mRNA CTD PMID:18414637 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G LEP leptin decreases expression EXP Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Roxarsone results in increased expression of MMP9 mRNA; Roxarsone results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
increases expression		 ISO Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of MTOR protein]
Roxarsone results in increased expression of MTOR mRNA		 CTD PMID:35985552 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions EXP Roxarsone results in increased phosphorylation of and results in increased activity of NOS3 protein CTD PMID:18414637 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 increases expression
multiple interactions		 ISO Roxarsone results in increased expression of PECAM1 protein
Semaxinib inhibits the reaction [Roxarsone results in increased expression of PECAM1 protein]		 CTD PMID:30028964 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PLG plasminogen decreases expression EXP Roxarsone results in decreased expression of PLG mRNA CTD PMID:18414637 NCBI chr 6:160,702,193...160,754,097
Ensembl chr 6:160,702,194...160,754,097 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions
increases expression		 ISO Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein; Sirolimus inhibits the reaction [Roxarsone results in increased expression of and results in increased phosphorylation of RPS6KB1 protein]
Roxarsone results in increased expression of RPS6KB1 mRNA		 CTD PMID:35985552 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO Roxarsone results in increased expression of and results in increased secretion of VEGFA protein CTD PMID:24035937 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        agrochemical 17514
          roxarsone 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            hydroxides 24049
                              oxoacid 22975
                                pnictogen oxoacid 13799
                                  arsenic oxoacid 4441
                                    arsonic acids 656
                                      arsonic acid 656
                                        organoarsonic acid 654
                                          phenylarsonic acid 16
                                            roxarsone 14
paths to the root