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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:roxarsone
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Accession:CHEBI:35817 term browser browse the term
Definition:An organoarsonic acid where the organyl group is 4-hydroxy-3-nitrophenyl.
Synonyms:exact_synonym: (4-hydroxy-3-nitrophenyl)arsonic acid
 related_synonym: 2-nitro-1-hydroxybenzene-4-arsonic acid;   3-Nitro;   3-nitro-4-hydroxybenzenearsonic acid;   3-nitro-4-hydroxyphenylarsonic acid;   4-hydroxy-3-nitrobenzenearsonic acid;   4-hydroxy-3-nitrophenylarsonic acid;   Formula=C6H6AsNO6;   InChI=1S/C6H6AsNO6/c9-6-2-1-4(7(10,11)12)3-5(6)8(13)14/h1-3,9H,(H2,10,11,12);   InChIKey=XMVJITFPVVRMHC-UHFFFAOYSA-N;   NSC-2101;   Ren-O-Sal;   SMILES=Oc1ccc(cc1[N+]([O-])=O)[As](O)(O)=O;   roxarson;   roxarsonum
 xref: Beilstein:1976533;   CAS:121-19-7;   Gmelin:1221211;   LINCS:LSM-5383
 xref_mesh: MESH:D012406
 xref: PMID:12724787;   PMID:12731831;   PMID:12731832;   PMID:18414637;   PMID:21388897;   Patent:DE224953;   Patent:GB226255;   Reaxys:1976533;   VSDB:3003;   Wikipedia:Roxarsone


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roxarsone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 decreases expression ISO Roxarsone results in decreased expression of ANGPT1 mRNA CTD PMID:18414637 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Cnmd chondromodulin decreases expression ISO Roxarsone results in decreased expression of CNMD mRNA CTD PMID:18414637 NCBI chr15:61,923,291...61,947,840
Ensembl chr15:61,923,299...61,947,764
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression ISO Roxarsone results in decreased expression of CXCL9 mRNA CTD PMID:18414637 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases secretion ISO Roxarsone results in increased secretion of ENPP2 protein CTD PMID:22952646 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Fhdc1 FH2 domain containing 1 decreases expression ISO Roxarsone results in decreased expression of INF1 mRNA CTD PMID:18414637 NCBI chr 2:183,450,608...183,487,820
Ensembl chr 2:183,450,619...183,487,820
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO Roxarsone results in increased expression of HGF mRNA CTD PMID:18414637 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Lep leptin decreases expression ISO Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Roxarsone results in increased expression of MMP9 mRNA; Roxarsone results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Roxarsone results in increased phosphorylation of and results in increased activity of NOS3 protein CTD PMID:18414637 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression
multiple interactions
ISO Roxarsone results in increased expression of PECAM1 protein
Semaxinib inhibits the reaction [Roxarsone results in increased expression of PECAM1 protein]
CTD PMID:30028964 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Plg plasminogen decreases expression ISO Roxarsone results in decreased expression of PLG mRNA CTD PMID:18414637 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Roxarsone results in increased expression of and results in increased secretion of VEGFA protein CTD PMID:24035937 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        agrochemical 14435
          roxarsone 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  arsenic oxoacid 3497
                                    arsonic acids 90
                                      arsonic acid 90
                                        organoarsonic acid 90
                                          phenylarsonic acid 14
                                            roxarsone 12
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