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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ruthenium molecular entity
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Accession:CHEBI:35734 term browser browse the term
Synonyms:related_synonym: ruthenium compounds;   ruthenium molecular entities


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ruthenium red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] CTD PMID:32652086 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] CTD PMID:32652086 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AGRP agouti related neuropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] CTD PMID:32652086 NCBI chr16:67,482,571...67,483,547
Ensembl chr16:67,482,571...67,483,547 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA] CTD PMID:32652086 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium] CTD PMID:24457011 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G ATG5 autophagy related 5 multiple interactions ISO Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG5 protein] CTD PMID:34308505 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G ATG7 autophagy related 7 multiple interactions ISO Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG7 protein] CTD PMID:34308505 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO [Aconitine co-treated with Ruthenium Red] results in increased expression of BAX protein CTD PMID:37506855 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions ISO Ruthenium Red inhibits the reaction [Dronabinol affects the secretion of CALCA protein] CTD PMID:17828286 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G CASP12 caspase 12 (gene/pseudogene) multiple interactions EXP [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:19631781 NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO		 [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein]
[Aconitine co-treated with Ruthenium Red] results in increased cleavage of CASP3 protein		 CTD PMID:19631781 PMID:23219522 PMID:37506855 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCK cholecystokinin multiple interactions ISO [N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein] CTD PMID:26979077 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of CXCL8 mRNA] CTD PMID:16173059 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
G GHSR growth hormone secretagogue receptor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] CTD PMID:32652086 NCBI chr 3:172,443,291...172,448,456
Ensembl chr 3:172,443,291...172,448,456 		JBrowse link
G GRM1 glutamate metabotropic receptor 1 multiple interactions ISO Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 6:146,027,707...146,437,601
Ensembl chr 6:146,027,646...146,437,601 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO		 Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]		 CTD PMID:16173059 PMID:32652086 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS insulin multiple interactions ISO Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G LEP leptin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased lipidation of MAP1LC3B protein] CTD PMID:34308505 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO		 Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK1 protein]
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]		 CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO		 Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCU mitochondrial calcium uniporter multiple interactions ISO [Aconitine co-treated with Ruthenium Red] results in increased expression of MCU protein CTD PMID:37506855 NCBI chr10:72,692,143...72,887,694
Ensembl chr10:72,692,143...72,887,694 		JBrowse link
G MFN2 mitofusin 2 multiple interactions ISO Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein] CTD PMID:20886221 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G MICU1 mitochondrial calcium uptake 1 multiple interactions ISO Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of MICU1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of MICU1 protein] CTD PMID:37337224 NCBI chr10:72,367,340...72,626,079
Ensembl chr10:72,367,340...72,626,131 		JBrowse link
G MMP1 matrix metallopeptidase 1 affects expression
multiple interactions		 EXP Ruthenium Red affects the expression of MMP1 mRNA; Ruthenium Red affects the expression of MMP1 protein
Ruthenium Red inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]		 CTD PMID:17508023 PMID:21245013 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21466812 PMID:22882778 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:20886221 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NPY neuropeptide Y multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] CTD PMID:32652086 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821 		JBrowse link
G POMC proopiomelanocortin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein] CTD PMID:37337224 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] CTD PMID:32652086 NCBI chr 7:151,556,127...151,877,115
Ensembl chr 7:151,556,124...151,877,214 		JBrowse link
G PYY peptide YY multiple interactions ISO [Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form] CTD PMID:26979077 NCBI chr17:43,952,733...44,004,445
Ensembl chr17:43,952,733...44,004,469 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein] CTD PMID:32652086 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 decreases activity
multiple interactions		 EXP
ISO		 Ruthenium Red results in decreased activity of TRPA1 protein
Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]
Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15046718 PMID:15843607 PMID:17684094 PMID:23994502 NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
affects binding		 EXP
ISO		 Ruthenium Red inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]
Ruthenium Red binds to TRPV1 protein
Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Cobalt]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]
Ruthenium Red binds to and results in decreased activity of TRPV1 protein; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]		 CTD PMID:11140687 PMID:18172555 PMID:18230619 PMID:23264033 PMID:23747933 More... NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411 		JBrowse link
G TRPV3 transient receptor potential cation channel subfamily V member 3 multiple interactions ISO Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA]		 CTD PMID:20086034 PMID:32652086 NCBI chr17:3,510,502...3,557,812
Ensembl chr17:3,510,502...3,557,812 		JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 multiple interactions
decreases activity		 ISO [Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine CTD PMID:20064552 NCBI chr12:109,783,087...109,833,398
Ensembl chr12:109,783,087...109,833,406 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      molecular entity 25998
        transition element molecular entity 18598
          iron group molecular entity 1757
            ruthenium molecular entity 43
              ruthenium coordination entity + 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  metal atom 20590
                    transition element atom 19042
                      d-block element atom 19034
                        iron group element atom 1766
                          ruthenium atom 62
                            ruthenium molecular entity 43
                              ruthenium coordination entity + 43
paths to the root