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G |
ACACA |
acetyl-CoA carboxylase alpha |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] |
CTD |
PMID:32652086 |
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NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
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G |
ADIPOQ |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] |
CTD |
PMID:32652086 |
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NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
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G |
AGRP |
agouti related neuropeptide |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] |
CTD |
PMID:32652086 |
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NCBI chr16:67,482,571...67,483,547
Ensembl chr16:67,482,571...67,483,547
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G |
AKT1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA] |
CTD |
PMID:32652086 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
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G |
APP |
amyloid beta precursor protein |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium] |
CTD |
PMID:24457011 |
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NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128
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G |
ATG5 |
autophagy related 5 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG5 protein] |
CTD |
PMID:34308505 |
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NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791
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G |
ATG7 |
autophagy related 7 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased expression of ATG7 protein] |
CTD |
PMID:34308505 |
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NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665
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G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[Aconitine co-treated with Ruthenium Red] results in increased expression of BAX protein |
CTD |
PMID:37506855 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
CALCA |
calcitonin related polypeptide alpha |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Dronabinol affects the secretion of CALCA protein] |
CTD |
PMID:17828286 |
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NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354
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G |
CASP12 |
caspase 12 (gene/pseudogene) |
multiple interactions |
EXP |
[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein] |
CTD |
PMID:19631781 |
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NCBI chr11:104,883,286...104,898,460
Ensembl chr11:104,885,718...104,898,670
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G |
CASP3 |
caspase 3 |
multiple interactions |
EXP ISO |
[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein] [Aconitine co-treated with Ruthenium Red] results in increased cleavage of CASP3 protein |
CTD |
PMID:19631781 PMID:23219522 PMID:37506855 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CCK |
cholecystokinin |
multiple interactions |
ISO |
[N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein] |
CTD |
PMID:26979077 |
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NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of CXCL8 mRNA] |
CTD |
PMID:16173059 |
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NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
GFAP |
glial fibrillary acidic protein |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] |
CTD |
PMID:32652086 |
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NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937
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G |
GHRL |
ghrelin and obestatin prepropeptide |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] |
CTD |
PMID:32652086 |
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NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947
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G |
GHSR |
growth hormone secretagogue receptor |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 3:172,443,291...172,448,456
Ensembl chr 3:172,443,291...172,448,456
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G |
GRM1 |
glutamate metabotropic receptor 1 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] |
CTD |
PMID:14622174 |
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NCBI chr 6:146,027,707...146,437,601
Ensembl chr 6:146,027,646...146,437,601
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G |
IGF1 |
insulin like growth factor 1 |
multiple interactions |
EXP |
Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] |
CTD |
PMID:20539001 |
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NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
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G |
IL6 |
interleukin 6 |
multiple interactions |
EXP ISO |
Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA] Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein] |
CTD |
PMID:16173059 PMID:32652086 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
INS |
insulin |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] |
CTD |
PMID:14622148 |
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NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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G |
LEP |
leptin |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] |
CTD |
PMID:32652086 |
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NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
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G |
MAP1LC3B |
microtubule associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Cadmium Compounds results in increased lipidation of MAP1LC3B protein] |
CTD |
PMID:34308505 |
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NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions |
EXP ISO |
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK1 protein] Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
CTD |
PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions |
EXP ISO |
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein] Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
CTD |
PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MCU |
mitochondrial calcium uniporter |
multiple interactions |
ISO |
[Aconitine co-treated with Ruthenium Red] results in increased expression of MCU protein |
CTD |
PMID:37506855 |
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NCBI chr10:72,692,143...72,887,694
Ensembl chr10:72,692,143...72,887,694
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G |
MFN2 |
mitofusin 2 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein] |
CTD |
PMID:20886221 |
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NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211
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G |
MICU1 |
mitochondrial calcium uptake 1 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of MICU1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of MICU1 protein] |
CTD |
PMID:37337224 |
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NCBI chr10:72,367,340...72,626,079
Ensembl chr10:72,367,340...72,626,131
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G |
MMP1 |
matrix metallopeptidase 1 |
affects expression multiple interactions |
EXP |
Ruthenium Red affects the expression of MMP1 mRNA; Ruthenium Red affects the expression of MMP1 protein Ruthenium Red inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein] |
CTD |
PMID:17508023 PMID:21245013 |
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NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
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G |
MPO |
myeloperoxidase |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:21466812 PMID:22882778 |
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NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
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G |
NFKB1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
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G |
NPPA |
natriuretic peptide A |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:20886221 |
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NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
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G |
NPY |
neuropeptide Y |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
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G |
PIK3R1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821
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G |
POMC |
proopiomelanocortin |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
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G |
PRKAA1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [tianhuang inhibits the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein]]; Ruthenium Red promotes the reaction [Dexamethasone results in decreased expression of and results in decreased phosphorylation of PRKAA1 protein] |
CTD |
PMID:37337224 |
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NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374
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G |
PRKAG2 |
protein kinase AMP-activated non-catalytic subunit gamma 2 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 7:151,556,127...151,877,115
Ensembl chr 7:151,556,124...151,877,214
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G |
PYY |
peptide YY |
multiple interactions |
ISO |
[Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form] |
CTD |
PMID:26979077 |
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NCBI chr17:43,952,733...44,004,445
Ensembl chr17:43,952,733...44,004,469
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G |
TNF |
tumor necrosis factor |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein] |
CTD |
PMID:32652086 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TRPA1 |
transient receptor potential cation channel subfamily A member 1 |
decreases activity multiple interactions |
EXP ISO |
Ruthenium Red results in decreased activity of TRPA1 protein Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein] Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:15046718 PMID:15843607 PMID:17684094 PMID:23994502 |
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NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584
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G |
TRPV1 |
transient receptor potential cation channel subfamily V member 1 |
multiple interactions affects binding |
EXP ISO |
Ruthenium Red inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] Ruthenium Red binds to TRPV1 protein Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; Ruthenium Red inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Cobalt]; Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein] Ruthenium Red binds to and results in decreased activity of TRPV1 protein; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA] |
CTD |
PMID:11140687 PMID:18172555 PMID:18230619 PMID:23264033 PMID:23747933 PMID:30496739 PMID:32652086 More...
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NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411
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G |
TRPV3 |
transient receptor potential cation channel subfamily V member 3 |
multiple interactions |
ISO |
Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium] Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA] |
CTD |
PMID:20086034 PMID:32652086 |
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NCBI chr17:3,510,502...3,557,812
Ensembl chr17:3,510,502...3,557,812
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G |
TRPV4 |
transient receptor potential cation channel subfamily V member 4 |
multiple interactions decreases activity |
ISO |
[Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine |
CTD |
PMID:20064552 |
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NCBI chr12:109,783,087...109,833,398
Ensembl chr12:109,783,087...109,833,406
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G |
VEGFA |
vascular endothelial growth factor A |
multiple interactions |
EXP |
Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] |
CTD |
PMID:20539001 |
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NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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