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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ruthenium coordination entity
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Accession:CHEBI:35733 term browser browse the term
Synonyms:related_synonym: ruthenium coordination compound;   ruthenium coordination compounds;   ruthenium coordination entities


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ruthenium red term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] CTD PMID:32652086 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] CTD PMID:32652086 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agrp agouti related neuropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] CTD PMID:32652086 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA] CTD PMID:32652086 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium] CTD PMID:24457011 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Ruthenium Red inhibits the reaction [Dronabinol affects the secretion of CALCA protein] CTD PMID:17828286 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein] CTD PMID:19631781 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in decreased cleavage of CASP3 protein] CTD PMID:19631781 PMID:23219522 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cck cholecystokinin multiple interactions ISO [N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine co-treated with Ruthenium Red] inhibits the reaction [deoxynivalenol results in increased expression of CCK protein]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of CCK protein] CTD PMID:26979077 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Ghsr growth hormone secretagogue receptor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] CTD PMID:32652086 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Ruthenium Red inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein]; Ruthenium Red inhibits the reaction [[3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] which results in increased abundance of Calcium] CTD PMID:14622174 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ruthenium Red inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
CTD PMID:16173059 PMID:32652086 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Lep leptin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK1 protein]
CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Aflatoxin B1 results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased phosphorylation of MAPK3 protein]; Ruthenium Red inhibits the reaction [Formaldehyde results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:16513848 PMID:23219522 PMID:23994502 PMID:27818125 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Ruthenium Red inhibits the reaction [Phenylephrine results in decreased expression of MFN2 protein] CTD PMID:20886221 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression
multiple interactions
ISO Ruthenium Red affects the expression of MMP1 mRNA; Ruthenium Red affects the expression of MMP1 protein
Ruthenium Red inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]
CTD PMID:17508023 PMID:21245013 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of MPO protein]; Ruthenium Red inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:21466812 PMID:22882778 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Ruthenium Red inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:20886221 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] CTD PMID:32652086 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] CTD PMID:32652086 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Pyy peptide YY multiple interactions ISO [Ruthenium Red co-treated with N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine] inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form]; Ruthenium Red inhibits the reaction [deoxynivalenol results in increased expression of PYY protein alternative form] CTD PMID:26979077 NCBI chr10:90,047,989...90,049,155
Ensembl chr10:90,047,993...90,049,112
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein] CTD PMID:32652086 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
decreases activity
ISO Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK1 protein]; Ruthenium Red inhibits the reaction [[allyl isothiocyanate co-treated with TRPA1 protein] results in increased phosphorylation of MAPK3 protein]
Ruthenium Red inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [Arachidonic Acid results in increased activity of TRPA1 protein]; Ruthenium Red inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]
Ruthenium Red results in decreased activity of TRPA1 protein
CTD PMID:15046718 PMID:15843607 PMID:17684094 PMID:23994502 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects binding
ISO
EXP
Ruthenium Red inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; Ruthenium Red inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]
Ruthenium Red binds to TRPV1 protein
Ruthenium Red inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; Ruthenium Red inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]
Ruthenium Red binds to and results in decreased activity of TRPV1 protein; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]
CTD PMID:11140687 PMID:18172555 PMID:18230619 PMID:23747933 PMID:30496739 PMID:32652086 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions EXP
ISO
Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]
Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA]
CTD PMID:20086034 PMID:32652086 NCBI chr10:59,829,755...59,863,780
Ensembl chr10:59,831,241...59,860,987
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions
decreases activity
EXP [Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine CTD PMID:20064552 NCBI chr12:47,698,915...47,737,902
Ensembl chr12:47,698,947...47,737,902
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Ruthenium Red inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] CTD PMID:20539001 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      molecular entity 19880
        transition element molecular entity 16461
          transition element coordination entity 11138
            ruthenium coordination entity 35
              CORM 3 0
              KP1019 0
              [(2R,2'R)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(2R,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(2S)-4-methyl-2-[(2S,4S)-4-methylpiperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium 0
              [(2R,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')](imidazolidin-1-yl)[(6S)-6-[(2S)-piperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium(2+) 0
              [(2R,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][N,N-dimethyl-3-\{4-[(4aR)-1,2,4a,10-tetrahydro-1,10-phenanthrolin-4-yl-kappa(2)N(1),N(10)]butoxy\}anilinato(2-)][(6S)-6-[(2R)-piperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium 0
              [(2S,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][N,N-dimethyl-3-(\{11-[(4aS)-1,2,4a,10-tetrahydro-1,10-phenanthrolin-4-yl-kappa(2)N(1),N(10)]undecyl\}oxy)anilinato(2-)][(6S)-6-[(2S)-piperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium 0
              [2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(1R,3S,5R,7R)-N-[(2R,2'R,3R,3'R,5S,5'S,6S,6'S)-2,2',3,3',5,5',6,6'-octafluoro-4'-(\{(2S,4S)-2-[(2S)-4-methyl-1,2,5,6-tetrahydropyridin-2-yl-kappaN]piperidin-4-yl-kappaN\}methyl)-1,1'-bi(cyclohexyl)-4-yl]tricyclo[3.3.1.1(3.7)]decan-2-aminato(2-)][3,4,5',6'-tetrahydro-1H,1'H-2,2'-bipyridinato(2-)-kappa(2)N(1),N(1')]ruthenium(2+) 0
              [2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(1R,3S,5R,7R)-N-[(2R,2'S,3S,3'R,5R,5'S,6S,6'S)-2,2',3,3',5,5',6,6'-octafluoro-4'-(\{(2R,4S)-2-[(2S)-4-methyl-1,2,5,6-tetrahydropyridin-2-yl-kappaN]piperidin-4-yl-kappaN\}methyl)-1,1'-bi(cyclohexyl)-4-yl]tricyclo[3.3.1.1(3.7)]decan-2-aminato(2-)][3,4,5',6'-tetrahydro-1H,1'H-2,2'-bipyridinato(2-)-kappa(2)N(1),N(1')]ruthenium(2+) 0
              dicarbonyl(triiodo)ruthenate(1-) 0
              hexaammineruthenium(2+) 0
              hexaammineruthenium(3+) 0
              hexachlororuthenate(2-) + 0
              ruthenium red 35
              ruthenocene 0
              tetrapropylammonium perruthenate 0
              tris(1,10-phenanthroline)ruthenium(2+) + 0
              tris(2,2'-bipyridine)ruthenium(II) + 0
              tris(2,2'-bipyridine)ruthenium(II) dichloride 0
              tris(4,4'-diphenyl-2,2'-bipyridine)ruthenium(II) + 0
              tris(4,4'-diphenyl-2,2'-bipyridine)ruthenium(II) chloride 0
              tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  metal atom 17316
                    transition element atom 16775
                      d-block element atom 16766
                        iron group element atom 862
                          ruthenium atom 47
                            ruthenium molecular entity 35
                              ruthenium coordination entity 35
                                CORM 3 0
                                KP1019 0
                                [(2R,2'R)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(2R,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(2S)-4-methyl-2-[(2S,4S)-4-methylpiperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium 0
                                [(2R,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')](imidazolidin-1-yl)[(6S)-6-[(2S)-piperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium(2+) 0
                                [(2R,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][N,N-dimethyl-3-\{4-[(4aR)-1,2,4a,10-tetrahydro-1,10-phenanthrolin-4-yl-kappa(2)N(1),N(10)]butoxy\}anilinato(2-)][(6S)-6-[(2R)-piperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium 0
                                [(2S,2'S)-2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][N,N-dimethyl-3-(\{11-[(4aS)-1,2,4a,10-tetrahydro-1,10-phenanthrolin-4-yl-kappa(2)N(1),N(10)]undecyl\}oxy)anilinato(2-)][(6S)-6-[(2S)-piperidin-2-yl-kappaN]-1,2,3,6-tetrahydropyridinato(2-)-kappaN]ruthenium 0
                                [2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(1R,3S,5R,7R)-N-[(2R,2'R,3R,3'R,5S,5'S,6S,6'S)-2,2',3,3',5,5',6,6'-octafluoro-4'-(\{(2S,4S)-2-[(2S)-4-methyl-1,2,5,6-tetrahydropyridin-2-yl-kappaN]piperidin-4-yl-kappaN\}methyl)-1,1'-bi(cyclohexyl)-4-yl]tricyclo[3.3.1.1(3.7)]decan-2-aminato(2-)][3,4,5',6'-tetrahydro-1H,1'H-2,2'-bipyridinato(2-)-kappa(2)N(1),N(1')]ruthenium(2+) 0
                                [2,2'-bipiperidinato(2-)-kappa(2)N(1),N(1')][(1R,3S,5R,7R)-N-[(2R,2'S,3S,3'R,5R,5'S,6S,6'S)-2,2',3,3',5,5',6,6'-octafluoro-4'-(\{(2R,4S)-2-[(2S)-4-methyl-1,2,5,6-tetrahydropyridin-2-yl-kappaN]piperidin-4-yl-kappaN\}methyl)-1,1'-bi(cyclohexyl)-4-yl]tricyclo[3.3.1.1(3.7)]decan-2-aminato(2-)][3,4,5',6'-tetrahydro-1H,1'H-2,2'-bipyridinato(2-)-kappa(2)N(1),N(1')]ruthenium(2+) 0
                                dicarbonyl(triiodo)ruthenate(1-) 0
                                hexaammineruthenium(2+) 0
                                hexaammineruthenium(3+) 0
                                hexachlororuthenate(2-) + 0
                                ruthenium red 35
                                ruthenocene 0
                                tetrapropylammonium perruthenate 0
                                tris(1,10-phenanthroline)ruthenium(2+) + 0
                                tris(2,2'-bipyridine)ruthenium(II) + 0
                                tris(2,2'-bipyridine)ruthenium(II) dichloride 0
                                tris(4,4'-diphenyl-2,2'-bipyridine)ruthenium(II) + 0
                                tris(4,4'-diphenyl-2,2'-bipyridine)ruthenium(II) chloride 0
                                tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) 0
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