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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enrofloxacin
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Accession:CHEBI:35720 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets.
Synonyms:exact_synonym: 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: Baytril;   Formula=C19H22FN3O3;   InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26);   InChIKey=SPFYMRJSYKOXGV-UHFFFAOYSA-N;   SMILES=C1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)F)N4CCN(CC4)CC
 xref: CAS:93106-60-6;   Drug_Central:1017;   HMDB:HMDB0029861;   KEGG:D02473;   LINCS:LSM-3709
 xref_mesh: MESH:C052904
 xref: PMID:15967281;   PMID:19376344;   PMID:24380725;   PMID:26963935;   PMID:8828132;   Patent:KR20130080422;   Patent:RU2491922;   Patent:US4659603;   Reaxys:5307824;   VSDB:1762;   Wikipedia:Enrofloxacin



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enrofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity
EXP Selenium inhibits the reaction [enrofloxacin results in decreased activity of CAT protein] CTD PMID:27083143 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Enrofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19848
    role 19824
      biological role 19822
        antimicrobial agent 18193
          enrofloxacin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    main group molecular entity 19796
                      s-block molecular entity 19629
                        hydrogen molecular entity 19616
                          hydrides 19122
                            inorganic hydride 18123
                              pnictogen hydride 18112
                                nitrogen hydride 18019
                                  azane 17826
                                    ammonia 17825
                                      organic amino compound 17825
                                        tertiary amino compound 10141
                                          N-alkylpiperazine 3395
                                            enrofloxacin 2
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