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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:enrofloxacin
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Accession:CHEBI:35720 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is 1,4-dihydroquinoline-3-carboxylic acid substituted by an oxo group at position 4, a fluoro group at position 6, a cyclopropyl group at position 1 and a 4-ethylpiperazin-1-yl group at position 7. It is a veterinary antibacterial agent used for the treatment of pets.
Synonyms:exact_synonym: 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: Baytril;   Formula=C19H22FN3O3;   InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26);   InChIKey=SPFYMRJSYKOXGV-UHFFFAOYSA-N;   SMILES=C1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)F)N4CCN(CC4)CC
 xref: CAS:93106-60-6;   Drug_Central:1017;   HMDB:HMDB0029861;   KEGG:D02473;   LINCS:LSM-3709
 xref_mesh: MESH:C052904
 xref: PMID:15967281;   PMID:19376344;   PMID:24380725;   PMID:26963935;   PMID:8828132;   Patent:KR20130080422;   Patent:RU2491922;   Patent:US4659603;   Reaxys:5307824;   VSDB:1762;   Wikipedia:Enrofloxacin



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enrofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity
EXP Selenium inhibits the reaction [enrofloxacin results in decreased activity of CAT protein] CTD PMID:27083143 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Enrofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        antimicrobial agent 17758
          enrofloxacin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        aromatic carboxylic acid 11796
                                          quinolinemonocarboxylic acid 102
                                            enrofloxacin 2
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