CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sulfamic acids
Accession: CHEBI:35719
browse the term
Definition: H2NS(=O)2OH (sulfamic acid) and its N-hydrocarbyl derivatives.
Synonyms: xref: KEGG:C01614
cyclic_relationship: is_conjugate_acid_of CHEBI:131822
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
bupirimate results in increased activity of NR1I2 protein
CTD
PMID:16565514 PMID:21924250
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
bupirimate results in increased activity of NR1I3 protein
CTD
PMID:21924250
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Car1
carbonic anhydrase 1
decreases activity
ISO
sulfamic acid results in decreased activity of CA1 protein
CTD
PMID:15664814
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car2
carbonic anhydrase 2
decreases activity
ISO
sulfamic acid results in decreased activity of CA2 protein
CTD
PMID:15664814
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car4
carbonic anhydrase 4
decreases activity
ISO
sulfamic acid results in decreased activity of CA4 protein
CTD
PMID:15664814
NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
G
Car5a
carbonic anhydrase 5A
decreases activity
ISO
sulfamic acid results in decreased activity of CA5A protein
CTD
PMID:15664814
NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
G
Car9
carbonic anhydrase 9
decreases activity
ISO
sulfamic acid results in decreased activity of CA9 protein
CTD
PMID:15664814
NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
G
Il18
interleukin 18
increases expression
ISO
sulfamic acid results in increased expression of IL18 protein
CTD
PMID:23063874
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Sts
steroid sulfatase
decreases activity
ISO
sulfamic acid analog results in decreased activity of STS protein
CTD
PMID:15597397
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
G
Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions increases expression
EXP
Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein]
CTD
PMID:18473823
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcc1
ATP binding cassette subfamily C member 1
increases expression
EXP
topiramate results in increased expression of ABCC1 protein
CTD
PMID:18473823
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
G
Abcc2
ATP binding cassette subfamily C member 2
increases expression
EXP
topiramate results in increased expression of ABCC2 protein
CTD
PMID:18473823
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Acadsb
acyl-CoA dehydrogenase, short/branched chain
increases expression
EXP
topiramate results in increased expression of ACADSB mRNA
CTD
PMID:16979414
NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379
G
Acsl4
acyl-CoA synthetase long-chain family member 4
decreases expression
EXP
topiramate results in decreased expression of ACSL4 mRNA
CTD
PMID:16979414
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
G
Adipoq
adiponectin, C1Q and collagen domain containing
increases expression increases secretion
ISO
topiramate results in increased expression of ADIPOQ mRNA topiramate results in increased secretion of ADIPOQ protein
CTD
PMID:12927809
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Adra2a
adrenoceptor alpha 2A
increases expression
ISO
topiramate results in increased expression of ADRA2A mRNA
CTD
PMID:22489711
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
G
Agxt
alanine--glyoxylate aminotransferase
increases expression
EXP
topiramate results in increased expression of AGXT mRNA
CTD
PMID:16979414
NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
Topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]; Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of AKT1 mRNA]
CTD
PMID:29753867 PMID:34266355
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
G
Ass1
argininosuccinate synthase 1
decreases expression
EXP
topiramate results in decreased expression of ASS1 mRNA
CTD
PMID:16979414
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
G
Avpr1a
arginine vasopressin receptor 1A
decreases expression
EXP
topiramate results in decreased expression of AVPR1A mRNA
CTD
PMID:16979414
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
G
Bdnf
brain-derived neurotrophic factor
multiple interactions
EXP
topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein]
CTD
PMID:29753867
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Calca
calcitonin-related polypeptide alpha
multiple interactions
EXP
Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein]
CTD
PMID:16942474
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
G
Capn6
calpain 6
increases expression
EXP
topiramate results in increased expression of CAPN6 mRNA
CTD
PMID:16979414
NCBI chr X:107,380,774...107,405,489
Ensembl chr X:107,380,774...107,405,489
G
Car1
carbonic anhydrase 1
multiple interactions
ISO
topiramate binds to and results in decreased activity of CA1 protein
CTD
PMID:17826101
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
G
Car12
carbonic anhydrase 12
decreases activity
ISO
topiramate results in decreased activity of CA12 protein
CTD
PMID:21314129
NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
G
Car2
carbonic anhydrase 2
multiple interactions decreases activity
ISO
topiramate binds to and results in decreased activity of CA2 protein topiramate results in decreased activity of CA2 protein
CTD
PMID:17826101 PMID:21314129
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car3
carbonic anhydrase 3
multiple interactions
ISO
topiramate binds to and results in decreased activity of CA3 protein
CTD
PMID:17826101
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
G
Casp3
caspase 3
affects expression multiple interactions
EXP
topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein Topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]; Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 mRNA]
CTD
PMID:19148780 PMID:29753867 PMID:34266355
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Cebpa
CCAAT/enhancer binding protein alpha
decreases expression
EXP
topiramate results in decreased expression of CEBPA mRNA
CTD
PMID:16979414
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
G
Chka
choline kinase alpha
decreases expression
EXP
topiramate results in decreased expression of CHKA mRNA
CTD
PMID:16979414
NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
G
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
decreases expression
EXP
topiramate results in decreased expression of CHRNA7 mRNA
CTD
PMID:16979414
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
G
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
decreases expression
EXP
topiramate results in decreased expression of CITED2 mRNA
CTD
PMID:16979414
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
G
Cnr1
cannabinoid receptor 1
affects expression
ISO
topiramate affects the expression of CNR1 mRNA
CTD
PMID:22017514
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
G
Creb1
cAMP responsive element binding protein 1
multiple interactions
EXP
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein]
CTD
PMID:29753867
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases activity
ISO
topiramate results in decreased activity of CYP17A1 protein
CTD
PMID:15730543
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases activity increases expression
ISO
Topiramate results in increased activity of CYP3A4 protein Topiramate results in increased expression of CYP3A4 mRNA; Topiramate results in increased expression of CYP3A4 protein
CTD
PMID:14636322
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Drd2
dopamine receptor D2
increases expression
ISO
topiramate results in increased expression of DRD2 mRNA
CTD
PMID:22489711
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Dusp1
dual specificity phosphatase 1
increases expression
EXP
topiramate results in increased expression of DUSP1 mRNA
CTD
PMID:16979414
NCBI chr10:16,680,478...16,683,275
G
Fabp3
fatty acid binding protein 3
decreases expression
EXP
topiramate results in decreased expression of FABP3 mRNA
CTD
PMID:16979414
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
EXP
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]
CTD
PMID:11123204
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
G
Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
multiple interactions
EXP
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]
CTD
PMID:11123204
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
G
Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
multiple interactions
EXP
topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]
CTD
PMID:11123204
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
EXP
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]
CTD
PMID:11123204
NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
EXP
topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]
CTD
PMID:11123204
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
G
Glul
glutamate-ammonia ligase
decreases activity
ISO
topiramate results in decreased activity of GLUL protein
CTD
PMID:10323596
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
G
Gnai2
G protein subunit alpha i2
decreases expression
EXP
topiramate results in decreased expression of GNAI2 mRNA
CTD
PMID:16979414
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Got2
glutamic-oxaloacetic transaminase 2
increases expression
EXP
topiramate results in increased expression of GOT2 mRNA
CTD
PMID:16979414
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
G
Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
decreases expression
EXP
topiramate results in decreased expression of GPAM mRNA
CTD
PMID:16979414
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
G
Gpd2
glycerol-3-phosphate dehydrogenase 2
increases expression
EXP
topiramate results in increased expression of GPD2 mRNA
CTD
PMID:16979414
NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
G
Gria2
glutamate ionotropic receptor AMPA type subunit 2
multiple interactions
EXP
topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA]
CTD
PMID:29753867
NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
G
Grik1
glutamate ionotropic receptor kainate type subunit 1
affects response to substance affects binding
ISO EXP
GRIK1 gene SNP affects the susceptibility to topiramate topiramate binds to Grik1 protein
CTD RGD
PMID:19331489 PMID:12904467
RGD:731146
NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
EXP
topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein]
CTD
PMID:29753867
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gtf2a2
general transcription factor 2A subunit 2
increases expression
EXP
topiramate results in increased expression of GTF2A2 mRNA
CTD
PMID:16979414
NCBI chr 8:70,662,447...70,675,576
Ensembl chr 8:70,662,428...70,675,569
G
Gyg1
glycogenin 1
decreases expression
EXP
topiramate results in decreased expression of GYG1 mRNA
CTD
PMID:16979414
NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
EXP
topiramate results in increased expression of HMGCS1 mRNA
CTD
PMID:16979414
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
decreases activity
ISO
topiramate results in decreased activity of HSD3B2 protein
CTD
PMID:15730543
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
EXP
topiramate results in increased expression of IDI1 mRNA
CTD
PMID:16979414
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
G
Ifi30
IFI30, lysosomal thiol reductase
multiple interactions
EXP
[topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA
CTD
PMID:21849664
NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175
G
Igf1
insulin-like growth factor 1
decreases expression
EXP
topiramate results in decreased expression of IGF1 mRNA
CTD
PMID:16979414
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
increases expression
EXP
topiramate results in increased expression of ITPR1 mRNA
CTD
PMID:16979414
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
topiramate results in decreased activity of KCNH2 protein
CTD
PMID:15716081
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Me1
malic enzyme 1
decreases expression
EXP
topiramate results in decreased expression of ME1 mRNA
CTD
PMID:16979414
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
G
Mvd
mevalonate diphosphate decarboxylase
increases expression
EXP
topiramate results in increased expression of MVD mRNA
CTD
PMID:16979414
NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
G
Nos2
nitric oxide synthase 2
increases expression
EXP
topiramate results in increased expression of NOS2 protein
CTD
PMID:14511393
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Npy
neuropeptide Y
increases expression
EXP
topiramate results in increased expression of NPY protein
CTD
PMID:17572454
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
topiramate results in increased activity of NR1I2 protein
CTD
PMID:14636322
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr2f2
nuclear receptor subfamily 2, group F, member 2
decreases expression
EXP
topiramate results in decreased expression of NR2F2 mRNA
CTD
PMID:16979414
NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
decreases expression
EXP
topiramate results in decreased expression of NR4A2 mRNA
CTD
PMID:16979414
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
G
Pde4b
phosphodiesterase 4B
decreases expression
EXP
topiramate results in decreased expression of PDE4B mRNA
CTD
PMID:16979414
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
G
Pdk4
pyruvate dehydrogenase kinase 4
decreases expression
EXP
topiramate results in decreased expression of PDK4 mRNA
CTD
PMID:16979414
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
G
Pick1
protein interacting with PRKCA 1
multiple interactions
EXP
topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein]
CTD
PMID:29753867
NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848
G
Plcd4
phospholipase C, delta 4
decreases expression
EXP
topiramate results in decreased expression of PLCD4 mRNA
CTD
PMID:16979414
NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
G
Pld1
phospholipase D1
increases expression
EXP
topiramate results in increased expression of PLD1 mRNA
CTD
PMID:16979414
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
G
Ppp5c
protein phosphatase 5, catalytic subunit
increases expression
EXP
topiramate results in increased expression of PPP5C mRNA
CTD
PMID:16979414
NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
G
Prkag1
protein kinase AMP-activated non-catalytic subunit gamma 1
decreases expression
EXP
topiramate results in decreased expression of PRKAG1 mRNA
CTD
PMID:16979414
NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561
G
Prkar2b
protein kinase cAMP-dependent type II regulatory subunit beta
decreases expression
EXP
topiramate results in decreased expression of PRKAR2B mRNA
CTD
PMID:16979414
NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
G
Rps6
ribosomal protein S6
multiple interactions
EXP
Topiramate inhibits the reaction [Pentylenetetrazole results in increased expression of RPS6 mRNA]
CTD
PMID:34266355
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
G
RT1-CE16
RT1 class I, locus CE16
affects expression
ISO
Topiramate affects the expression of HLA-A mRNA
CTD
PMID:25811541
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
G
RT1-DMb
RT1 class II, locus DMb
affects expression
ISO
topiramate affects the expression of HLA-DMB mRNA
CTD
PMID:25811541
NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
G
Scd
stearoyl-CoA desaturase
decreases expression
EXP
topiramate results in decreased expression of SCD1 mRNA
CTD
PMID:16979414
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Slc16a1
solute carrier family 16 member 1
increases expression
EXP
topiramate results in increased expression of SLC16A1 mRNA
CTD
PMID:16979414
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
G
Slc37a4
solute carrier family 37 member 4
decreases expression
EXP
topiramate results in decreased expression of SLC37A4 mRNA
CTD
PMID:16979414
NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
G
Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
G
Slc6a6
solute carrier family 6 member 6
decreases expression
EXP
topiramate results in decreased expression of SLC6A6 mRNA
CTD
PMID:16979414
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
G
Slc7a1
solute carrier family 7 member 1
decreases expression
EXP
topiramate results in decreased expression of SLC7A1 mRNA
CTD
PMID:16979414
NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
G
Sqle
squalene epoxidase
decreases expression
EXP
topiramate results in decreased expression of SQLE mRNA
CTD
PMID:16979414
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
G
Srebf1
sterol regulatory element binding transcription factor 1
increases expression
EXP
topiramate results in increased expression of SREBF1 mRNA
CTD
PMID:16979414
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Th
tyrosine hydroxylase
affects expression increases expression
ISO
topiramate affects the expression of TH mRNA topiramate results in increased expression of TH mRNA
CTD
PMID:22017514 PMID:22489711
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
EXP
topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA]
CTD
PMID:21849664
NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
G
Ucp3
uncoupling protein 3
decreases expression
EXP
topiramate results in decreased expression of UCP3 mRNA
CTD
PMID:16979414
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
G
Ugt2b7
UDP glucuronosyltransferase family 2 member B7
affects response to substance
ISO
UGT2B7 gene SNP affects the susceptibility to topiramate
CTD
PMID:18686368
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19811
chemical entity
19840
atom
19809
nonmetal atom
19747
sulfur atom
17687
sulfur molecular entity
17715
sulfur oxoacid derivative
14178
sulfonic acid derivative
11576
sulfamic acids
88
(3Z)-dec-3-en-1-ylsulfamic acid
0
(3Z,6Z)-dodeca-3,6-dien-1-ylsulfamic acid
0
(7-methyloctyl)sulfamic acid
0
(8-methylnonyl)sulfamic acid
0
(9-methyldecyl)sulfamic acid
0
2-O-sulfo-beta-L-threo-hex-4-enopyranuronosyl-(1->4)-beta-D-GlcpNS
0
Delta(4)-beta-D-GlcpA-(1->4)-D-GlcpNS6S
0
Delta(4)-beta-D-GlcpA2S-(1->4)-beta-D-GlcpNS6S
0
HP_dp02_0003 +
0
HP_dp02_0008
0
N(5)-sulfo-FADH2
0
N-sulfoglucosamine +
0
SQ 26,992
0
\{4-[2,2-bis(5-methyl-1,2,4-oxadiazol-3-yl)-3-phenylpropyl]phenyl\}sulfamic acid
0
alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S
0
alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S-(1->4)-alpha-D-GlcpNS6S-(1->4)-L-IdopA 2S
0
benzenamine sulfate
0
beta-D-GlcpA-(1->4)-alpha-D-GlcpNS
0
beta-D-GlcpA2S-(1->4)-alpha-D-GlcpNS6S
0
cyclohexylsulfamic acid
0
decylsulfamic acid
0
nonylsulfamic acid
0
octylsulfamic acid
0
sulfamic acid +
88
Path 2
CHEBI ontology
19811
subatomic particle
19809
composite particle
19809
hadron
19840
baryon
19809
nucleon
19809
atomic nucleus
19809
atom
19809
main group element atom
19759
p-block element atom
19759
chalcogen
19515
oxygen atom
19520
oxygen molecular entity
19490
hydroxides
19300
oxoacid
18725
chalcogen oxoacid
13752
sulfur oxoacid
13540
sulfonic acid
11576
sulfonic acid derivative
11576
sulfamic acids
88
(3Z)-dec-3-en-1-ylsulfamic acid
0
(3Z,6Z)-dodeca-3,6-dien-1-ylsulfamic acid
0
(7-methyloctyl)sulfamic acid
0
(8-methylnonyl)sulfamic acid
0
(9-methyldecyl)sulfamic acid
0
2-O-sulfo-beta-L-threo-hex-4-enopyranuronosyl-(1->4)-beta-D-GlcpNS
0
Delta(4)-beta-D-GlcpA-(1->4)-D-GlcpNS6S
0
Delta(4)-beta-D-GlcpA2S-(1->4)-beta-D-GlcpNS6S
0
HP_dp02_0003 +
0
HP_dp02_0008
0
N(5)-sulfo-FADH2
0
N-sulfoglucosamine +
0
SQ 26,992
0
\{4-[2,2-bis(5-methyl-1,2,4-oxadiazol-3-yl)-3-phenylpropyl]phenyl\}sulfamic acid
0
alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S
0
alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S-(1->4)-alpha-D-GlcpNS6S-(1->4)-L-IdopA 2S
0
benzenamine sulfate
0
beta-D-GlcpA-(1->4)-alpha-D-GlcpNS
0
beta-D-GlcpA2S-(1->4)-alpha-D-GlcpNS6S
0
cyclohexylsulfamic acid
0
decylsulfamic acid
0
nonylsulfamic acid
0
octylsulfamic acid
0
sulfamic acid +
88