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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfamic acids
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Accession:CHEBI:35719 term browser browse the term
Definition:H2NS(=O)2OH (sulfamic acid) and its N-hydrocarbyl derivatives.
Synonyms:xref: KEGG:C01614
 cyclic_relationship: is_conjugate_acid_of CHEBI:131822



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bupirimate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO bupirimate results in increased activity of NR1I2 protein CTD PMID:16565514 PMID:21924250 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO bupirimate results in increased activity of NR1I3 protein CTD PMID:21924250 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
sulfamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca4 carbonic anhydrase 4 decreases activity ISO sulfamic acid results in decreased activity of CA4 protein CTD PMID:15664814 NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501
JBrowse link
G Ca5a carbonic anhydrase 5A decreases activity ISO sulfamic acid results in decreased activity of CA5A protein CTD PMID:15664814 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO sulfamic acid results in decreased activity of CA9 protein CTD PMID:15664814 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838
JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO sulfamic acid results in decreased activity of CA1 protein CTD PMID:15664814 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO sulfamic acid results in decreased activity of CA2 protein CTD PMID:15664814 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Il18 interleukin 18 increases expression ISO sulfamic acid results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Sts steroid sulfatase decreases activity ISO sulfamic acid analog results in decreased activity of STS protein CTD PMID:15597397 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
topiramate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
EXP Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP topiramate results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP topiramate results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain increases expression EXP topiramate results in increased expression of ACADSB mRNA CTD PMID:16979414 NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression EXP topiramate results in decreased expression of ACSL4 mRNA CTD PMID:16979414 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
increases secretion
ISO topiramate results in increased expression of ADIPOQ mRNA
topiramate results in increased secretion of ADIPOQ protein
CTD PMID:12927809 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression ISO topiramate results in increased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase increases expression EXP topiramate results in increased expression of AGXT mRNA CTD PMID:16979414 NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:29753867 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP topiramate results in decreased expression of ASS1 mRNA CTD PMID:16979414 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP topiramate results in decreased expression of AVPR1A mRNA CTD PMID:16979414 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] CTD PMID:29753867 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Ca12 carbonic anhydrase 12 decreases activity ISO topiramate results in decreased activity of CA12 protein CTD PMID:21314129 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO topiramate binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:16942474 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Capn6 calpain 6 increases expression EXP topiramate results in increased expression of CAPN6 mRNA CTD PMID:16979414 NCBI chr  X:107,380,774...107,405,489
Ensembl chr  X:107,380,774...107,405,489
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO topiramate binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO topiramate binds to and results in decreased activity of CA2 protein
topiramate results in decreased activity of CA2 protein
CTD PMID:17826101 PMID:21314129 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
EXP topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]
CTD PMID:19148780 PMID:29753867 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP topiramate results in decreased expression of CEBPA mRNA CTD PMID:16979414 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Chka choline kinase alpha decreases expression EXP topiramate results in decreased expression of CHKA mRNA CTD PMID:16979414 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression EXP topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP topiramate results in decreased expression of CITED2 mRNA CTD PMID:16979414 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO topiramate affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO topiramate results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
increases expression
ISO Topiramate results in increased activity of CYP3A4 protein
Topiramate results in increased expression of CYP3A4 mRNA; Topiramate results in increased expression of CYP3A4 protein
CTD PMID:14636322 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO topiramate results in increased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP topiramate results in increased expression of DUSP1 mRNA CTD PMID:16979414 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression EXP topiramate results in decreased expression of FABP3 mRNA CTD PMID:16979414 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions EXP topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO topiramate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP topiramate results in decreased expression of GNAI2 mRNA CTD PMID:16979414 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP topiramate results in increased expression of GOT2 mRNA CTD PMID:16979414 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP topiramate results in decreased expression of GPAM mRNA CTD PMID:16979414 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP topiramate results in increased expression of GPD2 mRNA CTD PMID:16979414 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] CTD PMID:29753867 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 affects response to substance
affects binding
ISO
EXP
GRIK1 gene SNP affects the susceptibility to topiramate
topiramate binds to Grik1 protein
CTD
RGD
PMID:19331489 PMID:12904467 RGD:731146 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] CTD PMID:29753867 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression EXP topiramate results in increased expression of GTF2A2 mRNA CTD PMID:16979414 NCBI chr 8:70,662,395...70,675,576
Ensembl chr 8:70,662,428...70,675,569
JBrowse link
G Gyg1 glycogenin 1 decreases expression EXP topiramate results in decreased expression of GYG1 mRNA CTD PMID:16979414 NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP topiramate results in increased expression of HMGCS1 mRNA CTD PMID:16979414 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO topiramate results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP topiramate results in increased expression of IDI1 mRNA CTD PMID:16979414 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifi30 IFI30, lysosomal thiol reductase multiple interactions EXP [topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA CTD PMID:21849664 NCBI chr16:18,675,651...18,679,857
Ensembl chr16:18,675,613...18,681,175
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP topiramate results in decreased expression of IGF1 mRNA CTD PMID:16979414 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP topiramate results in increased expression of ITPR1 mRNA CTD PMID:16979414 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP topiramate results in decreased expression of ME1 mRNA CTD PMID:16979414 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP topiramate results in increased expression of MVD mRNA CTD PMID:16979414 NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP topiramate results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npy neuropeptide Y increases expression EXP topiramate results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO topiramate results in increased activity of NR1I2 protein CTD PMID:14636322 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression EXP topiramate results in decreased expression of NR2F2 mRNA CTD PMID:16979414 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP topiramate results in decreased expression of NR4A2 mRNA CTD PMID:16979414 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP topiramate results in decreased expression of PDE4B mRNA CTD PMID:16979414 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP topiramate results in decreased expression of PDK4 mRNA CTD PMID:16979414 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pick1 protein interacting with PRKCA 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] CTD PMID:29753867 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP topiramate results in decreased expression of PLCD4 mRNA CTD PMID:16979414 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
JBrowse link
G Pld1 phospholipase D1 increases expression EXP topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit increases expression EXP topiramate results in increased expression of PPP5C mRNA CTD PMID:16979414 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456
JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 decreases expression EXP topiramate results in decreased expression of PRKAG1 mRNA CTD PMID:16979414 NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression EXP topiramate results in decreased expression of PRKAR2B mRNA CTD PMID:16979414 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO topiramate affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP topiramate results in decreased expression of SCD1 mRNA CTD PMID:16979414 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression EXP topiramate results in increased expression of SLC16A1 mRNA CTD PMID:16979414 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP topiramate results in decreased expression of SLC37A4 mRNA CTD PMID:16979414 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc6a6 solute carrier family 6 member 6 decreases expression EXP topiramate results in decreased expression of SLC6A6 mRNA CTD PMID:16979414 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression EXP topiramate results in decreased expression of SLC7A1 mRNA CTD PMID:16979414 NCBI chr12:6,628,214...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Sqle squalene epoxidase decreases expression EXP topiramate results in decreased expression of SQLE mRNA CTD PMID:16979414 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP topiramate results in increased expression of SREBF1 mRNA CTD PMID:16979414 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Th tyrosine hydroxylase affects expression
increases expression
ISO topiramate affects the expression of TH mRNA
topiramate results in increased expression of TH mRNA
CTD PMID:22017514 PMID:22489711 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] CTD PMID:21849664 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP topiramate results in decreased expression of UCP3 mRNA CTD PMID:16979414 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance ISO UGT2B7 gene SNP affects the susceptibility to topiramate CTD PMID:18686368 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          sulfur atom 16403
            sulfur molecular entity 16403
              sulfur oxoacid derivative 12284
                sulfonic acid derivative 7366
                  sulfamic acids 86
                    (3Z)-dec-3-en-1-ylsulfamic acid 0
                    (3Z,6Z)-dodeca-3,6-dien-1-ylsulfamic acid 0
                    (7-methyloctyl)sulfamic acid 0
                    (8-methylnonyl)sulfamic acid 0
                    (9-methyldecyl)sulfamic acid 0
                    2-O-sulfo-beta-L-threo-hex-4-enopyranuronosyl-(1->4)-beta-D-GlcpNS 0
                    Delta(4)-beta-D-GlcpA-(1->4)-D-GlcpNS6S 0
                    Delta(4)-beta-D-GlcpA2S-(1->4)-beta-D-GlcpNS6S 0
                    HP_dp02_0003 + 0
                    HP_dp02_0008 0
                    N(5)-sulfo-FADH2 0
                    N-sulfoglucosamine + 0
                    SQ 26,992 0
                    \{4-[2,2-bis(5-methyl-1,2,4-oxadiazol-3-yl)-3-phenylpropyl]phenyl\}sulfamic acid 0
                    alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S 0
                    alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S-(1->4)-alpha-D-GlcpNS6S-(1->4)-L-IdopA 2S 0
                    benzenamine sulfate 0
                    beta-D-GlcpA-(1->4)-alpha-D-GlcpNS 0
                    beta-D-GlcpA2S-(1->4)-alpha-D-GlcpNS6S 0
                    cyclohexylsulfamic acid 0
                    decylsulfamic acid 0
                    nonylsulfamic acid 0
                    octylsulfamic acid 0
                    sulfamic acid + 86
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      chalcogen 19471
                        oxygen atom 19447
                          oxygen molecular entity 19447
                            hydroxides 19175
                              oxoacid 18500
                                chalcogen oxoacid 11499
                                  sulfur oxoacid 11107
                                    sulfonic acid 7366
                                      sulfonic acid derivative 7366
                                        sulfamic acids 86
                                          (3Z)-dec-3-en-1-ylsulfamic acid 0
                                          (3Z,6Z)-dodeca-3,6-dien-1-ylsulfamic acid 0
                                          (7-methyloctyl)sulfamic acid 0
                                          (8-methylnonyl)sulfamic acid 0
                                          (9-methyldecyl)sulfamic acid 0
                                          2-O-sulfo-beta-L-threo-hex-4-enopyranuronosyl-(1->4)-beta-D-GlcpNS 0
                                          Delta(4)-beta-D-GlcpA-(1->4)-D-GlcpNS6S 0
                                          Delta(4)-beta-D-GlcpA2S-(1->4)-beta-D-GlcpNS6S 0
                                          HP_dp02_0003 + 0
                                          HP_dp02_0008 0
                                          N(5)-sulfo-FADH2 0
                                          N-sulfoglucosamine + 0
                                          SQ 26,992 0
                                          \{4-[2,2-bis(5-methyl-1,2,4-oxadiazol-3-yl)-3-phenylpropyl]phenyl\}sulfamic acid 0
                                          alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S 0
                                          alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S-(1->4)-alpha-D-GlcpNS6S-(1->4)-L-IdopA 2S 0
                                          benzenamine sulfate 0
                                          beta-D-GlcpA-(1->4)-alpha-D-GlcpNS 0
                                          beta-D-GlcpA2S-(1->4)-alpha-D-GlcpNS6S 0
                                          cyclohexylsulfamic acid 0
                                          decylsulfamic acid 0
                                          nonylsulfamic acid 0
                                          octylsulfamic acid 0
                                          sulfamic acid + 86
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