|
G |
Tacr1 |
tachykinin receptor 1 |
multiple interactions |
ISO |
[alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] |
CTD |
PMID:18210232 |
|
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
|
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP ISO |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX protein] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; asiatic acid inhibits the reaction [Glucose results in increased expression of BAX mRNA] |
CTD |
PMID:29108773 PMID:30802477 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 protein] asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]] |
CTD |
PMID:29108773 PMID:30802477 |
|
NCBI chr13:22,689,783...22,853,920
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; asiatic acid inhibits the reaction [Glucose results in increased activity of CASP3 protein] |
CTD |
PMID:29108773 PMID:30802477 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP9 protein] |
CTD |
PMID:29108773 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
EXP |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein] |
CTD |
PMID:29108773 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] |
CTD |
PMID:29108773 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL1B protein] |
CTD |
PMID:30802477 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]] [Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein] |
CTD |
PMID:30802477 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; asiatic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:30802477 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein] |
CTD |
PMID:29108773 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] |
CTD |
PMID:29108773 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
|
|
G |
Por |
cytochrome p450 oxidoreductase |
multiple interactions |
EXP |
asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] |
CTD |
PMID:29108773 |
|
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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|
G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
[Glutamic Acid co-treated with asiatic acid] results in increased expression of PPARGC1A protein |
CTD |
PMID:22447225 |
|
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] |
CTD |
PMID:30802477 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] |
CTD |
PMID:30802477 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]] asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]] |
CTD |
PMID:30802477 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Vdac1 |
voltage-dependent anion channel 1 |
multiple interactions |
ISO |
asiatic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 protein] |
CTD |
PMID:18802751 |
|
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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|
|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
madecassoside results in decreased activity of CYP2C19 protein |
CTD |
PMID:21349323 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
madecassoside results in decreased activity of CYP3A4 protein |
CTD |
PMID:21349323 |
|
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression multiple interactions |
ISO |
ursolic acid results in decreased expression of ABCB1 mRNA; ursolic acid results in decreased expression of ABCB1 protein ABCB1 protein inhibits the reaction [ursolic acid results in increased susceptibility to Doxorubicin] |
CTD |
PMID:33009882 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases phosphorylation |
ISO |
ursolic acid results in increased phosphorylation of ACACA protein |
CTD |
PMID:24802810 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
decreases response to substance increases localization |
ISO |
AIFM1 mutant form results in decreased susceptibility to ursolic acid ursolic acid results in increased localization of AIFM1 protein |
CTD |
PMID:20630652 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
ursolic acid results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:19344998 PMID:24802810 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases activity |
ISO |
ursolic acid results in increased activity of BAK1 protein |
CTD |
PMID:20630652 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
ursolic acid results in increased expression of BAX protein |
CTD |
PMID:16012738 PMID:24051192 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions increases phosphorylation |
ISO |
ursolic acid results in decreased expression of BCL2 protein [ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein] |
CTD |
PMID:16012738 PMID:24802810 |
|
NCBI chr13:22,689,783...22,853,920
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|
G |
Becn1 |
beclin 1 |
multiple interactions |
ISO |
[ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein] |
CTD |
PMID:24802810 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity |
ISO |
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein]; ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein ursolic acid results in increased expression of CASP3 protein ursolic acid results in increased activity of CASP3 protein |
CTD |
PMID:16012738 PMID:19329757 PMID:20005942 PMID:24051192 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp7 |
caspase 7 |
increases activity |
ISO |
ursolic acid results in increased activity of CASP7 protein |
CTD |
PMID:19329757 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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|
G |
Casp8 |
caspase 8 |
increases activity |
ISO |
ursolic acid results in increased activity of CASP8 protein |
CTD |
PMID:20005942 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Cat |
catalase |
increases activity |
ISO |
ursolic acid results in increased activity of CAT protein |
CTD |
PMID:24051192 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
ursolic acid results in decreased expression of CCND1 mRNA; ursolic acid results in decreased expression of CCND1 protein |
CTD |
PMID:24566423 PMID:24802810 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
ursolic acid results in decreased expression of CCND3 protein |
CTD |
PMID:24802810 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
ursolic acid results in decreased expression of CCNE1 protein |
CTD |
PMID:24802810 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
ursolic acid results in decreased expression of CDK4 protein |
CTD |
PMID:24802810 |
|
NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
ursolic acid results in increased expression of CDKN1A protein |
CTD |
PMID:24802810 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
ursolic acid results in increased expression of CDKN1B protein |
CTD |
PMID:24802810 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
ISO |
ursolic acid results in increased phosphorylation of and results in increased degradation of CTNNB1 protein |
CTD |
PMID:24566423 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] |
CTD |
PMID:26513295 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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|
G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
ursolic acid affects the localization of CYCS protein |
CTD |
PMID:16012738 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
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|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
multiple interactions decreases activity |
ISO |
ursolic acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] ursolic acid results in decreased activity of CYP2C19 protein |
CTD |
PMID:15043991 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein] |
CTD |
PMID:24802810 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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|
G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
ursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein] |
CTD |
PMID:27567547 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]] |
CTD |
PMID:26100520 |
|
NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases phosphorylation |
ISO |
EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein] ursolic acid results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:24802810 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
|
|
G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions increases phosphorylation |
ISO |
EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:24802810 |
|
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
|
|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases expression |
ISO |
ursolic acid results in decreased expression of EIF4EBP1 protein |
CTD |
PMID:24802810 |
|
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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|
G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
increases activity |
ISO |
ursolic acid results in increased activity of ERN1 protein |
CTD |
PMID:24802810 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
ursolic acid inhibits the reaction [Choline results in increased activity of GPT protein] |
CTD |
PMID:27567547 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions increases expression |
ISO |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein] |
CTD |
PMID:24802810 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
|
G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
ursolic acid results in decreased expression of ICAM1 mRNA; ursolic acid results in decreased expression of ICAM1 protein |
CTD |
PMID:20005942 PMID:21539908 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il6 |
interleukin 6 |
decreases expression multiple interactions |
ISO |
ursolic acid results in decreased expression of IL6 protein [Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA] |
CTD |
PMID:20869956 PMID:23835587 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]] |
CTD |
PMID:23835587 PMID:26100520 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
|
|
G |
Lep |
leptin |
increases expression |
ISO |
ursolic acid results in increased expression of LEP protein |
CTD |
PMID:20869956 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:27274199 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:27274199 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:27274199 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:27274199 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression multiple interactions |
ISO EXP |
ursolic acid results in decreased expression of MMP2 mRNA 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein] |
CTD |
PMID:21539908 PMID:27274199 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
ISO EXP |
ursolic acid results in decreased expression of MMP9 mRNA 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein] |
CTD |
PMID:21539908 PMID:27274199 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation |
ISO |
ursodoxicoltaurine inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein] |
CTD |
PMID:24802810 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
[ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKB1 protein] |
CTD |
PMID:23835587 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
ursolic acid analog results in decreased phosphorylation of and results in increased expression of NFKBIA protein |
CTD |
PMID:26134000 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
decreases expression |
ISO |
ursolic acid results in decreased expression of NOS2 protein |
CTD |
PMID:24051192 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
ursolic acid inhibits the reaction [Choline results in increased expression of NOS3 protein] |
CTD |
PMID:27567547 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
ursolic acid results in increased cleavage of PARP1 protein |
CTD |
PMID:16012738 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein] |
CTD |
PMID:27274199 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
[ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]] |
CTD |
PMID:23835587 PMID:26100520 PMID:26513295 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
decreases activity |
ISO |
ursolic acid results in decreased activity of PTPN1 protein |
CTD |
PMID:27085377 PMID:29175190 |
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NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression |
ISO |
ursolic acid analog results in decreased expression of RELA mRNA; ursolic acid analog results in decreased expression of RELA protein |
CTD |
PMID:26134000 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO |
ursolic acid results in decreased expression of RPS6KB1 protein |
CTD |
PMID:24802810 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]] |
CTD |
PMID:26100520 |
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NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
Resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; ursolic acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]] |
CTD |
PMID:26100520 |
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NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
ISO |
ursolic acid results in decreased expression of TGFB1 protein |
CTD |
PMID:21539908 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein] |
CTD |
PMID:27274199 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tnf |
tumor necrosis factor |
decreases expression |
ISO |
ursolic acid results in decreased expression of TNF protein |
CTD |
PMID:24051192 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Top1 |
DNA topoisomerase I |
decreases activity |
ISO |
ursolic acid results in decreased activity of TOP1 protein |
CTD |
PMID:10860928 |
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NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
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G |
Top2a |
DNA topoisomerase II alpha |
decreases activity |
ISO |
ursolic acid results in decreased activity of TOP2A protein |
CTD |
PMID:10860928 |
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NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
ursolic acid results in decreased expression of VEGFA protein |
CTD |
PMID:24051192 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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