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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ursane
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Accession:CHEBI:35711 term browser browse the term
Definition:A triterpene that has formula C30H52.
Synonyms:related_synonym: Formula=C30H52;   InChI=1S/C30H52/c1-20-12-16-27(5)18-19-29(7)22(25(27)21(20)2)10-11-24-28(6)15-9-14-26(3,4)23(28)13-17-30(24,29)8/h20-25H,9-19H2,1-8H3/t20-,21+,22-,23+,24-,25+,27-,28+,29-,30-/m1/s1;   InChIKey=OOTXFYSZXCPMPG-BMYLZFHVSA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@@]4(C)CCCC(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]1(C)CC[C@@H](C)[C@H](C)[C@@]21[H]
 xref: Beilstein:3207208

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alpha-amyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tacr1 tachykinin receptor 1 multiple interactions ISO [alpha-amyrin co-treated with beta-amyrin] inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:18210232 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504 		JBrowse link
asiatic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of BAX protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; asiatic acid inhibits the reaction [Glucose results in increased expression of BAX mRNA]		 CTD PMID:29108773 PMID:30802477 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of BCL2 protein]
asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]		 CTD PMID:29108773 PMID:30802477 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; asiatic acid inhibits the reaction [Glucose results in increased activity of CASP3 protein]		 CTD PMID:29108773 PMID:30802477 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP9 protein] CTD PMID:29108773 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein] CTD PMID:29108773 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein] CTD PMID:29108773 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL1B protein]		 CTD PMID:30802477 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; asiatic acid inhibits the reaction [Glucose results in increased secretion of IL6 protein]		 CTD PMID:30802477 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; asiatic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:30802477 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein] CTD PMID:29108773 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29108773 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP asiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein] CTD PMID:29108773 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Glutamic Acid co-treated with asiatic acid] results in increased expression of PPARGC1A protein CTD PMID:22447225 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] CTD PMID:30802477 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] CTD PMID:30802477 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]
asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]]		 CTD PMID:30802477 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO asiatic acid inhibits the reaction [Hydrogen Peroxide results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 mRNA]; asiatic acid inhibits the reaction [Rotenone results in increased expression of VDAC1 protein] CTD PMID:18802751 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826 		JBrowse link
madecassoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO madecassoside results in decreased activity of CYP2C19 protein CTD PMID:21349323 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO madecassoside results in decreased activity of CYP3A4 protein CTD PMID:21349323 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
ursolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO ursolic acid results in increased phosphorylation of ACACA protein CTD PMID:24802810 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases response to substance
increases localization		 ISO AIFM1 mutant form results in decreased susceptibility to ursolic acid
ursolic acid results in increased localization of AIFM1 protein		 CTD PMID:20630652 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO ursolic acid results in decreased phosphorylation of AKT1 protein CTD PMID:19344998 PMID:24802810 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity ISO ursolic acid results in increased activity of BAK1 protein CTD PMID:20630652 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO ursolic acid results in increased expression of BAX protein CTD PMID:16012738 PMID:24051192 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
increases phosphorylation		 ISO ursolic acid results in decreased expression of BCL2 protein
[ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein]		 CTD PMID:16012738 PMID:24802810 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO [ursolic acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; ursolic acid inhibits the reaction [BCL2 protein binds to BECN1 protein] CTD PMID:24802810 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein]; ursolic acid results in increased cleavage of and results in increased activity of CASP3 protein
ursolic acid results in increased expression of CASP3 protein
ursolic acid results in increased activity of CASP3 protein		 CTD PMID:16012738 PMID:19329757 PMID:20005942 PMID:24051192 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity ISO ursolic acid results in increased activity of CASP7 protein CTD PMID:19329757 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 increases activity ISO ursolic acid results in increased activity of CASP8 protein CTD PMID:20005942 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase increases activity ISO ursolic acid results in increased activity of CAT protein CTD PMID:24051192 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ursolic acid results in decreased expression of CCND1 mRNA; ursolic acid results in decreased expression of CCND1 protein CTD PMID:24566423 PMID:24802810 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO ursolic acid results in decreased expression of CCND3 protein CTD PMID:24802810 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO ursolic acid results in decreased expression of CCNE1 protein CTD PMID:24802810 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO ursolic acid results in decreased expression of CDK4 protein CTD PMID:24802810 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO ursolic acid results in increased expression of CDKN1A protein CTD PMID:24802810 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO ursolic acid results in increased expression of CDKN1B protein CTD PMID:24802810 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO ursolic acid results in increased phosphorylation of and results in increased degradation of CTNNB1 protein CTD PMID:24566423 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO ursolic acid affects the localization of CYCS protein CTD PMID:16012738 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity		 ISO ursolic acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]
ursolic acid results in decreased activity of CYP2C19 protein		 CTD PMID:15043991 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein] CTD PMID:24802810 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Edn1 endothelin 1 multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased expression of EDN1 protein] CTD PMID:27567547 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]] CTD PMID:26100520 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]
ursolic acid results in increased phosphorylation of EIF2AK3 protein		 CTD PMID:24802810 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation		 ISO EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:24802810 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression ISO ursolic acid results in decreased expression of EIF4EBP1 protein CTD PMID:24802810 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases activity ISO ursolic acid results in increased activity of ERN1 protein CTD PMID:24802810 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased activity of GPT protein] CTD PMID:27567547 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein] CTD PMID:24802810 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO ursolic acid results in decreased expression of ICAM1 mRNA; ursolic acid results in decreased expression of ICAM1 protein CTD PMID:20005942 PMID:21539908 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 ISO ursolic acid results in decreased expression of IL6 protein
[Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]		 CTD PMID:20869956 PMID:23835587 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Glucaric Acid co-treated with ursolic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]] CTD PMID:23835587 PMID:26100520 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Lep leptin increases expression ISO ursolic acid results in increased expression of LEP protein CTD PMID:20869956 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein] CTD PMID:27274199 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein] CTD PMID:27274199 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein] CTD PMID:27274199 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein] CTD PMID:27274199 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions		 ISO
EXP		 ursolic acid results in decreased expression of MMP2 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]		 CTD PMID:21539908 PMID:27274199 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO
EXP		 ursolic acid results in decreased expression of MMP9 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]		 CTD PMID:21539908 PMID:27274199 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO ursodoxicoltaurine inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein] CTD PMID:24802810 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKB1 protein] CTD PMID:23835587 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO ursolic acid analog results in decreased phosphorylation of and results in increased expression of NFKBIA protein CTD PMID:26134000 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO ursolic acid results in decreased expression of NOS2 protein CTD PMID:24051192 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO ursolic acid inhibits the reaction [Choline results in increased expression of NOS3 protein] CTD PMID:27567547 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO ursolic acid results in increased cleavage of PARP1 protein CTD PMID:16012738 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein] CTD PMID:27274199 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [ursolic acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]]; ursolic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]] CTD PMID:23835587 PMID:26100520 PMID:26513295 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO ursolic acid results in decreased activity of PTPN1 protein CTD PMID:27085377 PMID:29175190 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO ursolic acid analog results in decreased expression of RELA mRNA; ursolic acid analog results in decreased expression of RELA protein CTD PMID:26134000 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO ursolic acid results in decreased expression of RPS6KB1 protein CTD PMID:24802810 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]; ursolic acid promotes the reaction [resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]] CTD PMID:26100520 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Resveratrol promotes the reaction [ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; ursolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; ursolic acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]] CTD PMID:26100520 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO ursolic acid results in decreased expression of TGFB1 protein CTD PMID:21539908 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]]; ursolic acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein] CTD PMID:27274199 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO ursolic acid results in decreased expression of TNF protein CTD PMID:24051192 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Top1 DNA topoisomerase I decreases activity ISO ursolic acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO ursolic acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO ursolic acid results in decreased expression of VEGFA protein CTD PMID:24051192 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          carbon atom 19639
            organic molecular entity 19639
              organic fundamental parent 18302
                natural product fundamental parent 13104
                  terpenoid fundamental parent 3498
                    ursane 69
                      11alpha-hydroxyasiatic acid 0
                      19alpha-hydroxyasiatic acid + 0
                      19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside 0
                      23-hydroxyursolic acid + 0
                      2alpha,19alpha-dihydroxy-3-oxo-12-ursen-28-oic acid 0
                      2alpha,3alpha,23-trihydroxyurs-12-en-28-oic acid 0
                      2alpha,3beta,23alpha-trihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                      3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]asiatic acid 0
                      3-oxo-23-hydroxyurs-12-en-28-oic acid 0
                      3beta,22alpha-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                      3beta,23-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                      3beta-hydroxyurs-20-en-28-oic acid 0
                      actinidic acid + 0
                      alpha-amyrin 1
                      asiatic acid + 17
                      clethroidoside H 0
                      euscaphic acid 0
                      madecassic acid + 2
                      madecassoside 2
                      regelin 0
                      rotundifolioside A 0
                      rotundifolioside H 0
                      rotundifolioside I 0
                      rotundifolioside J 0
                      salvin A 0
                      salvin B 0
                      trachelosperogenin B 0
                      triptohypol D 0
                      triptohypol E 0
                      triptotritepenonic acid A 0
                      triptotriterpenic acid C 0
                      ursolic acid + 59
                      weigelic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      s-block molecular entity 19491
                        hydrogen molecular entity 19483
                          hydrides 18748
                            organic hydride 18302
                              organic fundamental parent 18302
                                hydrocarbon 18030
                                  terpene 10277
                                    triterpene 674
                                      ursane 69
                                        11alpha-hydroxyasiatic acid 0
                                        19alpha-hydroxyasiatic acid + 0
                                        19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside 0
                                        23-hydroxyursolic acid + 0
                                        2alpha,19alpha-dihydroxy-3-oxo-12-ursen-28-oic acid 0
                                        2alpha,3alpha,23-trihydroxyurs-12-en-28-oic acid 0
                                        2alpha,3beta,23alpha-trihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                        3-O-[beta-D-glucopyranosyl]-28-O-[alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranosyl]asiatic acid 0
                                        3-oxo-23-hydroxyurs-12-en-28-oic acid 0
                                        3beta,22alpha-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                        3beta,23-dihydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside 0
                                        3beta-hydroxyurs-20-en-28-oic acid 0
                                        actinidic acid + 0
                                        alpha-amyrin 1
                                        asiatic acid + 17
                                        clethroidoside H 0
                                        euscaphic acid 0
                                        madecassic acid + 2
                                        madecassoside 2
                                        regelin 0
                                        rotundifolioside A 0
                                        rotundifolioside H 0
                                        rotundifolioside I 0
                                        rotundifolioside J 0
                                        salvin A 0
                                        salvin B 0
                                        trachelosperogenin B 0
                                        triptohypol D 0
                                        triptohypol E 0
                                        triptotritepenonic acid A 0
                                        triptotriterpenic acid C 0
                                        ursolic acid + 59
                                        weigelic acid 0
paths to the root