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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
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NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
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NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
EXP |
Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA; Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein |
CTD |
PMID:8660662 |
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NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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G |
TERT |
telomerase reverse transcriptase |
decreases expression |
EXP |
Tetrachlorodibenzodioxin results in decreased expression of TERT protein |
CTD |
PMID:23850740 |
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NCBI chr34:11,288,622...11,307,790
Ensembl chr34:11,288,622...11,307,951
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G |
CPNE6 |
copine 6 |
increases reduction |
EXP |
DHRS4 protein results in increased reduction of 9,10-phenanthrenequinone |
CTD |
PMID:17827741 |
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NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
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G |
ALPI |
alkaline phosphatase, intestinal |
increases chemical synthesis |
EXP |
ALPI protein results in increased chemical synthesis of acetophenone |
CTD |
PMID:1495895 |
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NCBI chr25:44,107,418...44,110,947
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Antipyrine results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
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NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
REN |
renin |
multiple interactions |
EXP |
Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] |
CTD |
PMID:6103674 |
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NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Clotrimazole results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
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NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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G |
NR1I3 |
nuclear receptor subfamily 1 group I member 3 |
affects binding increases activity |
EXP |
Clotrimazole binds to NR1I3 protein Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form |
CTD |
PMID:21778469 PMID:27732639 |
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NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
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G |
CYP2B6 |
cytochrome P450 2B11 |
increases hydroxylation |
EXP |
CYP2B6 protein results in increased hydroxylation of Cyclophosphamide |
CTD |
PMID:16546968 |
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NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
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G |
AVP |
arginine vasopressin |
decreases expression |
EXP |
Dexamethasone results in decreased expression of AVP protein |
CTD |
PMID:1934541 |
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NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
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G |
HSD11B1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases expression |
EXP |
Dexamethasone results in increased expression of HSD11B1 mRNA |
CTD |
PMID:21798686 |
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NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897
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G |
NPPA |
natriuretic peptide A |
increases expression |
EXP |
Dexamethasone results in increased expression of NPPA protein |
CTD |
PMID:1934541 |
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NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
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G |
CYP2B6 |
cytochrome P450 2B11 |
increases metabolic processing |
EXP |
CYP2B6 protein results in increased metabolism of Dextromethorphan |
CTD |
PMID:12637241 |
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NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
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G |
CYP2D15 |
cytochrome P450 family 2 subfamily D member 15 |
affects metabolic processing |
EXP |
CYP2D15 affects the metabolism of Dextromethorphan |
CTD |
PMID:7786018 |
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NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
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G |
CYP2C18 |
cytochrome P450 2C21 |
affects metabolic processing |
EXP |
CYP2C19 protein affects the metabolism of Diazepam |
CTD |
PMID:15801540 |
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NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
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G |
CYP3A12 |
cytochrome P-450 3A12 |
multiple interactions increases hydroxylation |
EXP |
Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] |
CTD |
PMID:15677349 |
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G |
CYP2C18 |
cytochrome P450 2C21 |
increases hydroxylation |
EXP |
CYP2C19 protein results in increased hydroxylation of Diclofenac |
CTD |
PMID:15677349 |
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NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
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G |
CYP2C41 |
cytochrome P450 2C41 |
affects metabolic processing |
EXP |
CYP2C9 protein affects the metabolism of Diclofenac |
CTD |
PMID:15801540 |
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Diclofenac results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Ibuprofen results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
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NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
EXP |
Ibuprofen results in increased expression of PTGS2 protein |
CTD |
PMID:16105799 |
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NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
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G |
HEXB |
hexosaminidase subunit beta |
multiple interactions |
EXP |
Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] |
CTD |
PMID:21671308 |
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NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Indomethacin results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
ATP2A2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions |
EXP |
[Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein |
CTD |
PMID:18820026 |
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NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
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G |
CYP2D15 |
cytochrome P450 family 2 subfamily D member 15 |
affects metabolic processing |
EXP |
CYP2D15 affects the metabolism of Metoprolol |
CTD |
PMID:7786018 |
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NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
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G |
EGR1 |
early growth response 1 |
multiple interactions |
EXP |
[Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein |
CTD |
PMID:18820026 |
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NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
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G |
GATA4 |
GATA binding protein 4 |
multiple interactions |
EXP |
[Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein |
CTD |
PMID:18820026 |
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NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
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G |
NAB1 |
NGFI-A binding protein 1 |
multiple interactions |
EXP |
[Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein |
CTD |
PMID:18820026 |
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NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
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G |
SLC8A1 |
solute carrier family 8 member A1 |
multiple interactions |
EXP |
[Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein |
CTD |
PMID:18820026 |
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NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
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G |
REN |
renin |
decreases activity |
EXP |
Nitroglycerin results in decreased activity of REN protein |
CTD |
PMID:8640982 |
|
NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
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G |
SLC22A6 |
solute carrier family 22 member 6 |
multiple interactions |
EXP |
[Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican |
CTD |
PMID:36243147 |
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NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Acetaminophen results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
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NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
UGT1A6 |
UDP glucuronosyltransferase 1 family, polypeptide A6 |
increases glucuronidation |
EXP |
UGT1A6 protein results in increased glucuronidation of Acetaminophen |
CTD |
PMID:11903872 |
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NCBI chr25:45,081,655...45,161,584
Ensembl chr25:45,032,130...45,160,941
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
affects metabolic processing |
EXP |
CYP1A2 protein affects the metabolism of Phenacetin |
CTD |
PMID:15801540 |
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NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Phenacetin results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
|
NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz |
CTD |
PMID:24389113 |
|
NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
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NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
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G |
ADRB2 |
adrenoceptor beta 2 |
multiple interactions |
EXP |
[Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine |
CTD |
PMID:2884805 |
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NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
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G |
NPPA |
natriuretic peptide A |
increases expression |
EXP |
Propranolol results in increased expression of NPPA protein |
CTD |
PMID:2566282 |
|
NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
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G |
REN |
renin |
multiple interactions decreases activity |
EXP |
Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] Propranolol results in decreased activity of REN protein |
CTD |
PMID:2566282 PMID:6103674 |
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NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
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G |
VIP |
vasoactive intestinal peptide |
decreases expression |
EXP |
Propranolol results in decreased expression of VIP protein |
CTD |
PMID:2566282 |
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NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions |
EXP |
allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] |
CTD |
PMID:15266218 |
|
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Ritonavir results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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G |
BAX |
BCL2 associated X, apoptosis regulator |
decreases expression |
EXP |
Spironolactone results in decreased expression of BAX protein |
CTD |
PMID:20082611 |
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NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
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G |
BCL2 |
BCL2 apoptosis regulator |
increases expression |
EXP |
Spironolactone results in increased expression of BCL2 protein |
CTD |
PMID:20082611 |
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NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
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G |
CAPN1 |
calpain 1 |
decreases expression |
EXP |
Spironolactone results in decreased expression of CAPN1 protein |
CTD |
PMID:20082611 |
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NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
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G |
CASP3 |
caspase 3 |
decreases expression |
EXP |
Spironolactone results in decreased expression of CASP3 protein |
CTD |
PMID:20082611 |
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NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
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G |
CAST |
calpastatin |
increases expression |
EXP |
Spironolactone results in increased expression of CAST protein |
CTD |
PMID:20082611 |
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NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959
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G |
MMP9 |
matrix metallopeptidase 9 |
decreases expression |
EXP |
Spironolactone results in decreased expression of MMP9 protein |
CTD |
PMID:20082611 |
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NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
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G |
TIMP1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
EXP |
Spironolactone results in increased expression of TIMP1 protein |
CTD |
PMID:20082611 |
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NCBI chr X:41,201,623...41,205,314
Ensembl chr X:41,201,638...41,205,310
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G |
SLC22A2 |
solute carrier family 22 member 2 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC22A2 protein |
CTD |
PMID:36669674 |
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NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
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G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
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NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
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G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
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NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
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G |
SLC47A2 |
solute carrier family 47 member 2 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC47A2 protein |
CTD |
PMID:36669674 |
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NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Troleandomycin results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
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NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions |
EXP |
[Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin |
CTD |
PMID:20510202 |
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NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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