The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically.
2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein; HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]
2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]
4-methylhistamine binds to and results in increased activity of HRH2 protein; [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 4-methylhistamine binds to and results in increased activity of HRH4 protein; [4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
4-methylhistamine affects the expression of IFNG protein 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]
4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein] alpha-methylhistamine binds to HRH3 protein 6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]; Endocannabinoids inhibits the reaction [alpha-methylhistamine binds to and results in increased activity of HRH3 protein]; Histamine H3 Antagonists inhibits the reaction [alpha-methylhistamine binds to HRH3 protein]
[alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; alpha-methylhistamine binds to and results in increased activity of HRH4 protein; HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein]
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL1B protein]]
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]]
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]]
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]]
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of RELA protein]]
alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of TNF protein]]
HRH2 protein promotes the reaction [clobenpropit results in increased expression of IL16 protein] [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit
clobenpropit binds to and results in decreased activity of HRH3 protein; clobenpropit inhibits the reaction [[Methylhistamines binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium] clobenpropit analog binds to HRH3 protein; clobenpropit binds to HRH3 protein [4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in decreased susceptibility to clobenpropit; [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine; clobenpropit binds to and results in decreased activity of HRH3 protein
1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to clobenpropit]; [clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CCND1 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CDK2 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1A protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein; clobenpropit binds to and results in increased activity of HRH4 protein clobenpropit binds to HRH4 protein
imetit inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]
imetit inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of [CKM protein binds to CKB protein]]
imetit binds to and results in increased activity of HRH3 protein Imetit binds to Hrh3 protein; imetit inhibits the reaction [N-methylhistamine binds to Hrh3 protein] imetit results in increased activity of HRH3 protein [imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; ciproxifan inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; imetit binds to and results in increased activity of HRH3 protein; Pertussis Toxin inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; thioperamide inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] [imetit binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium; imetit binds to and results in increased activity of HRH3 protein
[imetit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; imetit binds to and results in increased activity of HRH4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imetit results in increased expression of NTF3 protein]; [methylhistaprodifen co-treated with Dimaprit co-treated with imetit] results in increased expression of NTF3 protein; Pertussis Toxin inhibits the reaction [imetit results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [imetit results in increased expression of NTF3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [imetit results in increased expression of NTF3 protein]
[Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; Mianserin binds to and results in decreased activity of HTR2A protein
Mianserin results in increased expression of HTR2C protein 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]; Mianserin binds to and affects the activity of HTR2C protein [Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine; Mianserin binds to and results in decreased activity of HTR2C protein
Mianserin binds to HTR7 protein [Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
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