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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:histamine agonist
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Accession:CHEBI:35678 term browser browse the term
Definition:A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically.
Synonyms:related_synonym: histamine agonists



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2-pyridylethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP3 protein CTD PMID:17327230 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased cleavage of CASP9 protein CTD PMID:17327230 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein CTD PMID:17327230 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which affects the localization of CYCS protein CTD PMID:17327230 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO
EXP
2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein; HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA] CTD PMID:9657254 PMID:16143415 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA
HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]
CTD PMID:9657254 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein results in decreased susceptibility to [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] CTD PMID:17327230 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of TP53 protein CTD PMID:17327230 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
4-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 4-methylhistamine results in decreased expression of CCL2 protein CTD PMID:17507084 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein CTD PMID:14499251 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein] CTD PMID:12538815 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO 4-methylhistamine binds to and results in increased activity of HRH2 protein; [4-methylhistamine binds to and results in increased activity of HRH2 protein] which affects the expression of CD14 protein CTD PMID:14499251 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hrh4 histamine receptor H4 multiple interactions ISO 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 4-methylhistamine binds to and results in increased activity of HRH4 protein; [4-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium CTD PMID:17507084 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma affects expression
multiple interactions
ISO 4-methylhistamine affects the expression of IFNG protein
4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]
CTD PMID:11752121 PMID:12364868 PMID:17346280 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein] CTD PMID:11752121 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:11752121 PMID:12364868 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il18 interleukin 18 multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]; 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein] CTD PMID:11752121 PMID:12364868 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 4-methylhistamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; 4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:11752121 PMID:12538815 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
alpha-methylhistamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide decreases expression EXP alpha-methylhistamine results in decreased expression of GAL mRNA CTD PMID:11956952 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gast gastrin multiple interactions EXP alpha-methylhistamine inhibits the reaction [GAST protein modified form results in increased secretion of Histamine] CTD PMID:2470453 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Hdc histidine decarboxylase decreases expression EXP alpha-methylhistamine results in decreased expression of HDC mRNA CTD PMID:11956952 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hrh3 histamine receptor H3 multiple interactions
affects binding
EXP
ISO
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]
alpha-methylhistamine binds to HRH3 protein
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one inhibits the reaction [alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]]; alpha-methylhistamine binds to and results in increased activity of HRH3 protein; alpha-methylhistamine promotes the reaction [Guanosine Triphosphate binds to HRH3 protein]; Endocannabinoids inhibits the reaction [alpha-methylhistamine binds to and results in increased activity of HRH3 protein]; Histamine H3 Antagonists inhibits the reaction [alpha-methylhistamine binds to HRH3 protein]
CTD PMID:11956952 PMID:21634396 PMID:30102254 PMID:31369746 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Hrh4 histamine receptor H4 multiple interactions ISO [alpha-methylhistamine binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; alpha-methylhistamine binds to and results in increased activity of HRH4 protein; HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] CTD PMID:11181941 PMID:12235264 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345
JBrowse link
G Ifng interferon gamma affects expression ISO alpha-methylhistamine affects the expression of IFNG protein CTD PMID:17346280 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il16 interleukin 16 multiple interactions
increases expression
ISO HRH4 protein promotes the reaction [alpha-methylhistamine results in increased expression of IL16 protein] CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL1B protein]] CTD PMID:31369746 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of IL6 protein]] CTD PMID:31369746 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of NOS2 protein]] CTD PMID:31369746 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of PTGS2 protein]] CTD PMID:31369746 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of RELA protein]] CTD PMID:31369746 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO alpha-methylhistamine inhibits the reaction [Histamine H3 Antagonists inhibits the reaction [Valproic Acid results in increased expression of TNF protein]] CTD PMID:31369746 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
betahistine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions EXP Betahistine binds to and results in increased activity of HRH1 protein CTD PMID:16143415 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Betahistine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
clobenpropit term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 multiple interactions ISO clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein] CTD PMID:17196553 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO clobenpropit results in decreased expression of CCL2 protein CTD PMID:17507084 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CCND1 protein CTD PMID:22363581 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CDK2 protein CTD PMID:22363581 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1A protein CTD PMID:22363581 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein CTD PMID:22363581 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [Pyrilamine binds to and results in decreased activity of HRH1 protein] which results in decreased susceptibility to clobenpropit CTD PMID:16488453 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO
EXP
HRH2 protein promotes the reaction [clobenpropit results in increased expression of IL16 protein]
[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit
CTD PMID:12235264 PMID:16488453 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hrh3 histamine receptor H3 multiple interactions
affects binding
ISO
EXP
clobenpropit binds to and results in decreased activity of HRH3 protein; clobenpropit inhibits the reaction [[Methylhistamines binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium]
clobenpropit analog binds to HRH3 protein; clobenpropit binds to HRH3 protein
[4-(1H-imidazol-4-ylmethyl)piperidine binds to and results in increased activity of HRH3 protein] which results in decreased susceptibility to clobenpropit; [clobenpropit binds to and results in decreased activity of HRH3 protein] which results in decreased susceptibility to Scopolamine; clobenpropit binds to and results in decreased activity of HRH3 protein
CTD PMID:12706455 PMID:16488453 PMID:22003888 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Hrh4 histamine receptor H4 multiple interactions
affects binding
increases response to substance
ISO 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [[clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium]; 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine inhibits the reaction [HRH4 protein results in increased susceptibility to clobenpropit]; [clobenpropit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CCND1 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in decreased expression of CDK2 protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1A protein; [HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein; clobenpropit binds to and results in increased activity of HRH4 protein
clobenpropit binds to HRH4 protein
CTD PMID:17507084 PMID:22003888 PMID:22363581 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345
JBrowse link
G Ifng interferon gamma affects expression ISO clobenpropit affects the expression of IFNG protein CTD PMID:17346280 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il16 interleukin 16 multiple interactions
increases expression
ISO HRH2 protein promotes the reaction [clobenpropit results in increased expression of IL16 protein] CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il5 interleukin 5 affects expression ISO clobenpropit affects the expression of IL5 protein CTD PMID:17346280 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions EXP
ISO
clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:12411423 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
histamine phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor increases expression ISO histamine phosphate results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
imetit term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh3 histamine receptor H3 multiple interactions
increases activity
ISO
EXP
imetit binds to and results in increased activity of HRH3 protein
Imetit binds to Hrh3 protein; imetit inhibits the reaction [N-methylhistamine binds to Hrh3 protein]
imetit results in increased activity of HRH3 protein
[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; ciproxifan inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; imetit binds to and results in increased activity of HRH3 protein; Pertussis Toxin inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]; thioperamide inhibits the reaction [[imetit results in increased activity of HRH3 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]
[imetit binds to and results in increased activity of HRH3 protein] which results in increased transport of Calcium; imetit binds to and results in increased activity of HRH3 protein
CTD
RGD
PMID:12100006 PMID:12706455 PMID:21276809 PMID:10869375 RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Hrh4 histamine receptor H4 multiple interactions ISO [imetit binds to and results in increased activity of HRH4 protein] which results in increased abundance of Calcium; imetit binds to and results in increased activity of HRH4 protein CTD PMID:11181941 NCBI chr18:4,166,270...4,182,426
Ensembl chr18:4,166,270...4,246,345
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imetit results in increased expression of NTF3 protein]; [methylhistaprodifen co-treated with Dimaprit co-treated with imetit] results in increased expression of NTF3 protein; Pertussis Toxin inhibits the reaction [imetit results in increased expression of NTF3 protein]; Staurosporine inhibits the reaction [imetit results in increased expression of NTF3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [imetit results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
mianserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA CTD PMID:29882086 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Fgf4 fibroblast growth factor 4 decreases expression ISO Mianserin results in decreased expression of FGF4 mRNA CTD PMID:24154490 NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466
JBrowse link
G Gsc goosecoid homeobox decreases expression ISO Mianserin results in decreased expression of GSC mRNA CTD PMID:24154490 NCBI chr 6:123,388,072...123,390,111
Ensembl chr 6:123,388,072...123,390,111
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO [Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine; Mianserin binds to and results in decreased activity of HTR2A protein CTD PMID:10764922 PMID:10978843 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases expression
multiple interactions
ISO Mianserin results in increased expression of HTR2C protein
6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]; Mianserin binds to and affects the activity of HTR2C protein
[Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine; Mianserin binds to and results in decreased activity of HTR2C protein
CTD PMID:10978843 PMID:15213358 PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Mianserin binds to HTR7 protein
[Mianserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:14578406 PMID:20827463 NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Mianserin results in decreased expression of ID2 mRNA CTD PMID:24154490 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Mianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:34,061,705...34,309,128
Ensembl chr11:34,061,708...34,308,758
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Mianserin results in decreased expression of PRKCA mRNA CTD PMID:24154490 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Mianserin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Mianserin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA CTD PMID:29882086 NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239
JBrowse link
G Sox17 SRY-box transcription factor 17 decreases localization ISO Mianserin results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Mianserin results in decreased expression of TAC1 protein CTD PMID:8955926 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        pharmacological role 18852
          neurotransmitter agent 16458
            histaminergic drug 4620
              histamine agonist 55
                2-methylhistamine 0
                2-pyridylethylamine 8
                4-methylhistamine 12
                H1-receptor agonist + 2
                H3-receptor agonist + 14
                H4-receptor agonist + 15
                betazole + 0
                betazole dihydrochloride 0
                diltiazem(1+) + 0
                histamine phosphate 1
                mianserin + 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            neurotransmitter agent 16458
              histaminergic drug 4620
                histamine agonist 55
                  2-methylhistamine 0
                  2-pyridylethylamine 8
                  4-methylhistamine 12
                  H1-receptor agonist + 2
                  H3-receptor agonist + 14
                  H4-receptor agonist + 15
                  betazole + 0
                  betazole dihydrochloride 0
                  diltiazem(1+) + 0
                  histamine phosphate 1
                  mianserin + 17
paths to the root