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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:betahistine
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Accession:CHEBI:35677 term browser browse the term
Definition:An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.
Synonyms:exact_synonym: N-methyl-2-pyridin-2-ylethanamine
 related_synonym: 2-(beta-methylaminoethyl)pyridine;   2-[2-(methylamino)ethyl]pyridine;   Formula=C8H12N2;   InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3;   InChIKey=UUQMNUMQCIQDMZ-UHFFFAOYSA-N;   N-methyl-2-(2-pyridinyl)ethanamine;   N-methyl-2-pyridineethanamine;   SMILES=CNCCc1ccccn1;   [2-(2-pyridyl)ethyl]methylamine;   betahistina;   betahistinum
 xref: Beilstein:112294;   CAS:5638-76-6;   DrugBank:DB06698;   Drug_Central:346;   HMDB:HMDB0015644;   KEGG:D07522;   LINCS:LSM-4044
 xref_mesh: MESH:D001621
 xref: PMID:20530654;   PMID:22365373;   PMID:22745706;   PMID:7589314;   Reaxys:112294;   Wikipedia:Betahistine


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betahistine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions EXP Betahistine binds to and results in increased activity of HRH1 protein CTD PMID:16143415 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Betahistine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        pharmaceutical 19503
          drug 19471
            cardiovascular drug 8617
              vasodilator agent 5998
                betahistine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            inorganic hydride 18091
                              pnictogen hydride 18080
                                nitrogen hydride 17987
                                  azane 17796
                                    ammonia 17795
                                      organic amino compound 17795
                                        secondary amino compound 6828
                                          betahistine 2
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