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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:35677 term browser browse the term
Definition:An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.
Synonyms:exact_synonym: N-methyl-2-pyridin-2-ylethanamine
 related_synonym: 2-(beta-methylaminoethyl)pyridine;   2-[2-(methylamino)ethyl]pyridine;   Formula=C8H12N2;   InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3;   InChIKey=UUQMNUMQCIQDMZ-UHFFFAOYSA-N;   N-methyl-2-(2-pyridinyl)ethanamine;   N-methyl-2-pyridineethanamine;   SMILES=CNCCc1ccccn1;   [2-(2-pyridyl)ethyl]methylamine;   betahistina;   betahistinum
 xref: Beilstein:112294;   CAS:5638-76-6;   DrugBank:DB06698;   Drug_Central:346;   HMDB:HMDB0015644;   KEGG:D07522;   LINCS:LSM-4044
 xref_mesh: MESH:D001621
 xref: PMID:20530654;   PMID:22365373;   PMID:22745706;   PMID:7589314;   Reaxys:112294;   Wikipedia:Betahistine

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betahistine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions EXP Betahistine binds to and results in increased activity of HRH1 protein CTD PMID:16143415 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Betahistine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

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  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            cardiovascular drug 7618
              vasodilator agent 5733
                betahistine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        secondary amino compound 6538
                                          betahistine 2
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