Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:betahistine
go back to main search page
Accession:CHEBI:35677 term browser browse the term
Definition:An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.
Synonyms:exact_synonym: N-methyl-2-pyridin-2-ylethanamine
 related_synonym: 2-(beta-methylaminoethyl)pyridine;   2-[2-(methylamino)ethyl]pyridine;   Formula=C8H12N2;   InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3;   InChIKey=UUQMNUMQCIQDMZ-UHFFFAOYSA-N;   N-methyl-2-(2-pyridinyl)ethanamine;   N-methyl-2-pyridineethanamine;   SMILES=CNCCc1ccccn1;   [2-(2-pyridyl)ethyl]methylamine;   betahistina;   betahistinum
 xref: Beilstein:112294;   CAS:5638-76-6;   DrugBank:DB06698;   Drug_Central:346;   HMDB:HMDB0015644;   KEGG:D07522;   LINCS:LSM-4044
 xref_mesh: MESH:D001621
 xref: PMID:20530654;   PMID:22365373;   PMID:22745706;   PMID:7589314;   Reaxys:112294;   Wikipedia:Betahistine



show annotations for term's descendants           Sort by:
 
betahistine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions EXP Betahistine binds to and results in increased activity of HRH1 protein CTD PMID:16143415 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Betahistine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            cardiovascular drug 7706
              vasodilator agent 5826
                betahistine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            inorganic hydride 17691
                              pnictogen hydride 17671
                                nitrogen hydride 17543
                                  azane 17278
                                    ammonia 17277
                                      organic amino compound 17277
                                        secondary amino compound 6633
                                          betahistine 2
paths to the root