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ONTOLOGY REPORT - ANNOTATIONS


Term:betahistine
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Accession:CHEBI:35677 term browser browse the term
Definition:An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.
Synonyms:exact_synonym: N-methyl-2-pyridin-2-ylethanamine
 related_synonym: 2-(beta-methylaminoethyl)pyridine;   2-[2-(methylamino)ethyl]pyridine;   Formula=C8H12N2;   InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3;   InChIKey=UUQMNUMQCIQDMZ-UHFFFAOYSA-N;   N-methyl-2-(2-pyridinyl)ethanamine;   N-methyl-2-pyridineethanamine;   SMILES=CNCCc1ccccn1;   [2-(2-pyridyl)ethyl]methylamine;   betahistina;   betahistinum
 xref: Beilstein:112294 "Beilstein";   CAS:5638-76-6 "ChemIDplus";   CAS:5638-76-6 "NIST Chemistry WebBook";   DrugBank:DB06698;   Drug_Central:346 "DrugCentral";   HMDB:HMDB0015644;   KEGG:D07522;   LINCS:LSM-4044
 xref_mesh: MESH:D001621
 xref: PMID:20530654 "Europe PMC";   PMID:22365373 "Europe PMC";   PMID:22745706 "Europe PMC";   PMID:7589314 "Europe PMC";   Reaxys:112294 "Reaxys";   Wikipedia:Betahistine


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betahistine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            cardiovascular drug 7550
              vasodilator agent 5670
                betahistine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        secondary amino compound 6358
                                          betahistine 2
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