Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:abietane
go back to main search page
Accession:CHEBI:35673 term browser browse the term
Definition:A diterpene that has formula C20H36.
Synonyms:related_synonym: Formula=C20H36;   InChI=1S/C20H36/c1-14(2)15-7-9-17-16(13-15)8-10-18-19(3,4)11-6-12-20(17,18)5/h14-18H,6-13H2,1-5H3/t15-,16-,17-,18-,20+/m0/s1;   InChIKey=STIVVCHBLMGYSL-ZYNAIFEFSA-N;   SMILES=[H][C@@]12CC[C@@]3([H])C(C)(C)CCC[C@]3(C)[C@@]1([H])CC[C@@H](C2)C(C)C
 xref: Beilstein:2500550


show annotations for term's descendants           Sort by:
 
abietic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] CTD PMID:16904803 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO abietic acid results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO abietic acid results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO abietic acid results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
carnosic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
ISO salvin results in increased phosphorylation of AKT1 protein
salvin results in decreased phosphorylation of AKT1 protein
CTD PMID:25178877, PMID:25271104 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] CTD PMID:29854073 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
decreases phosphorylation
ISO salvin promotes the reaction [arsenic trioxide results in decreased phosphorylation of BAD protein]
salvin results in increased expression of BAD protein
salvin results in decreased phosphorylation of BAD protein
CTD PMID:23239002, PMID:28918123 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO salvin inhibits the reaction [Paraquat results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]
salvin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
salvin results in increased expression of BAX protein
CTD PMID:26577515, PMID:26686574, PMID:28918123, PMID:29854073 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]
salvin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]
salvin results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]
CTD PMID:25446857, PMID:26577515, PMID:26686574, PMID:28918123, PMID:29854073, PMID:30707903 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l2 Bcl2-like 2 multiple interactions ISO salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein] CTD PMID:24557422 NCBI chr15:33,543,774...33,549,165
Ensembl chr15:33,544,312...33,549,164
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]
salvin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP3 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP3 mRNA]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein]
CTD PMID:24557422, PMID:25271104, PMID:25446857, PMID:26577515, PMID:26686574, PMID:28159594, PMID:28918123, PMID:29854073, PMID:30707903, PMID:31705926 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]
CTD PMID:28918123, PMID:29854073 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases cleavage
ISO salvin results in increased activity of CASP9 protein
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP9 protein]
salvin results in increased cleavage of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP9 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP9 mRNA]; salvin inhibits the reaction [Paraquat results in increased activity of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]; salvin promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]
CTD PMID:23239002, PMID:26577515, PMID:26686574, PMID:28159594, PMID:28918123, PMID:29854073 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO salvin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of CAT mRNA]
salvin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD PMID:28159594, PMID:29854073 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [salvin co-treated with Tretinoin] results in increased expression of CD14 protein; salvin promotes the reaction [Calcitriol results in increased expression of CD14 protein] CTD PMID:11504768 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO salvin results in increased expression of CDKN1B protein
salvin promotes the reaction [arsenic trioxide results in increased expression of CDKN1B protein]
CTD PMID:23239002 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of FAS protein] CTD PMID:29854073 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO salvin inhibits the reaction [Oxidopamine results in increased expression of FIS1 protein] CTD PMID:31705926 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
salvin results in increased expression of GCLC mRNA
salvin results in increased expression of GCLC protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]
CTD PMID:18329808, PMID:25446857, PMID:26577515, PMID:26686574 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
salvin results in increased expression of GCLM protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of GCLM mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
CTD PMID:25446857, PMID:26577515, PMID:26686574, PMID:28159594 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of GPT protein] CTD PMID:29854073 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO salvin inhibits the reaction [Acrylamide results in decreased expression of GPX1 mRNA] CTD PMID:28159594 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
salvin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
salvin results in increased expression of GSR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
CTD PMID:25446857, PMID:26577515, PMID:26686574, PMID:29854073 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]
salvin results in increased expression of GSTP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSTP1 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]; salvin results in increased expression of and results in increased activity of GSTP1 protein
CTD PMID:25271104, PMID:26577515 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO salvin results in increased expression of HMOX1 mRNA; salvin results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]
CTD PMID:18329808, PMID:23942037, PMID:26686574 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] CTD PMID:23942037 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions
increases ubiquitination
ISO PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein] CTD PMID:31705926 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [salvin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGAM protein; salvin promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; salvin promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:11504768 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]
salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
CTD PMID:25446857, PMID:29854073 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK9 protein] CTD PMID:25446857 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO salvin inhibits the reaction [Oxidopamine results in decreased expression of MFN2 protein] CTD PMID:31705926 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO salvin results in decreased phosphorylation of MTOR protein CTD PMID:25178877, PMID:28918123 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity
multiple interactions
ISO salvin results in increased activity of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased activity of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin affects the localization of and results in increased activity of NFE2L2 protein; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 mRNA]; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 protein]
CTD PMID:26577515, PMID:26686574, PMID:28159594 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased phosphorylation of NFKBIA protein]; salvin results in increased phosphorylation of and results in increased degradation of NFKBIA protein
CTD PMID:21375325, PMID:25271104, PMID:29854073 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21375325 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO salvin results in increased expression of NQO1 mRNA
salvin results in increased expression of NQO1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of NQO1 mRNA]
CTD PMID:18329808, PMID:26686574, PMID:28159594 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions
increases expression
ISO OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 protein] CTD PMID:31705926 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases cleavage
ISO
EXP
Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]
salvin results in decreased expression of PARP1 protein
CTD PMID:25446857, PMID:28918123, PMID:30707903, PMID:31705926 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PINK1 protein] CTD PMID:30707903 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO salvin results in increased activity of PPARG protein CTD PMID:20696231 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
increases expression
ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]
salvin results in increased expression of PRKN protein
CTD PMID:30707903, PMID:31705926 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO salvin promotes the reaction [arsenic trioxide results in increased expression of PTEN mRNA]
salvin results in increased expression of PTEN mRNA
CTD PMID:23239002 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21375325 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein CTD PMID:11504768 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
affects localization
ISO salvin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of RELA protein]
salvin results in increased expression of RELA protein
salvin affects the localization of RELA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin affects the localization of RELA protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; salvin results in increased expression of and results in increased activity of RELA protein
CTD PMID:21375325, PMID:25271104, PMID:29854073, PMID:31705926 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rxra retinoid X receptor alpha increases expression
multiple interactions
ISO salvin results in increased expression of RXRA protein
Calcitriol promotes the reaction [salvin results in increased expression of RXRA protein]; Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein]
CTD PMID:11504768 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases expression
decreases expression
ISO salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein]
salvin results in increased expression of SHC1 mRNA
CTD PMID:24557422 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
ISO Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein]
salvin results in increased expression of SIRT1 mRNA; salvin results in increased expression of SIRT1 protein
CTD PMID:24557422 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP
salvin inhibits the reaction [Acrylamide results in decreased expression of SOD1 mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of SOD1 protein] CTD PMID:25446857, PMID:28159594 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SOD2 protein] CTD PMID:24557422, PMID:26577515, PMID:26686574 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:25446857 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21375325 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tyr tyrosinase decreases expression ISO salvin results in decreased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of and results in decreased ubiquitination of VDAC1 protein] CTD PMID:30707903 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression
ISO Calcitriol promotes the reaction [salvin results in increased expression of VDR protein]; Tetradecanoylphorbol Acetate promotes the reaction [salvin results in increased expression of VDR protein]; Tretinoin promotes the reaction [salvin results in increased expression of VDR protein] CTD PMID:11504768 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
Cryptotanshinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of ACHE protein CTD PMID:20350537 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of BCHE protein CTD PMID:20350537 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
ISO cryptotanshinone results in increased cleavage of CASP3 protein
cryptotanshinone results in increased activity of CASP3 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [cryptotanshinone results in increased cleavage of CASP3 protein]
CTD PMID:26564229, PMID:28600121 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO cryptotanshinone results in increased activity of CASP7 protein CTD PMID:26564229 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases activity ISO cryptotanshinone results in increased activity of CASP9 protein CTD PMID:26564229 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein] CTD PMID:30208247 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein] CTD PMID:30208247 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]
cryptotanshinone results in increased expression of CYP1A1 mRNA; cryptotanshinone results in increased expression of CYP1A1 protein
CTD PMID:21262253 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO cryptotanshinone results in increased expression of CYP1A2 mRNA; cryptotanshinone results in increased expression of CYP1A2 protein
cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]
CTD PMID:21262253 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form] CTD PMID:30208247 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein] CTD PMID:30208247 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog promotes the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein] CTD PMID:28600121 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:28600121 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO cryptotanshinone results in increased activity of NR1I2 protein CTD PMID:18805405 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cryptotanshinone results in increased cleavage of PARP1 protein CTD PMID:26564229 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein] CTD PMID:30208247 NCBI chr15:19,336,029...19,349,759
Ensembl chr15:19,338,175...19,350,210
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein] CTD PMID:30208247 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO cryptotanshinone results in decreased activity of PTPN1 protein CTD PMID:29031618 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229, PMID:28600121 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein] CTD PMID:28600121 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO cryptotanshinone results in decreased expression of TOP2A mRNA
cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein
CTD PMID:28716507 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO cryptotanshinone results in decreased expression of TOP2B mRNA CTD PMID:28716507 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
Miltirone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO miltirone results in decreased activity of CYP2C19 protein CTD PMID:25686904 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
Tanshinone I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression ISO tanshinone results in increased expression of ACADVL mRNA CTD PMID:15849732 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO tanshinone results in increased expression of ACSL1 mRNA CTD PMID:15849732 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:32097614 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tanshinone binds to and results in increased activity of AHR protein; tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO tanshinone results in decreased expression of ALDH1A3 mRNA CTD PMID:15849732 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO tanshinone results in decreased expression of ALDH3A2 mRNA CTD PMID:15849732 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Apoc1 apolipoprotein C1 increases expression ISO tanshinone results in increased expression of APOC1 mRNA CTD PMID:15849732 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Apom apolipoprotein M increases expression ISO tanshinone results in increased expression of APOM mRNA CTD PMID:15849732 NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO [[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [[tetraarsenic tetrasulfide co-treated with tanshinone] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] CTD PMID:18344322 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO tanshinone results in decreased expression of ASNS mRNA CTD PMID:15849732 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO tanshinone results in decreased expression of ASS1 mRNA CTD PMID:15849732 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases expression ISO tanshinone results in increased expression of ATP6V0B mRNA CTD PMID:15849732 NCBI chr 5:136,718,352...136,719,868 JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression ISO tanshinone results in increased expression of ATP6V1E1 mRNA CTD PMID:15849732 NCBI chr 4:153,351,434...153,373,558
Ensembl chr 4:153,351,421...153,373,649
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tanshinone results in increased expression of BAX protein CTD PMID:21699893 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression ISO tanshinone results in decreased expression of BCKDHB mRNA CTD PMID:15849732 NCBI chr 8:91,464,229...91,656,134
Ensembl chr 8:91,464,229...91,656,134
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanshinone results in decreased expression of BCL2 protein CTD PMID:16009009, PMID:19885617, PMID:20369472, PMID:21699893 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO tanshinone results in decreased expression of BIRC3 mRNA CTD PMID:15849732 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO tanshinone results in decreased expression of BIRC5 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of BIRC5 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA]
CTD PMID:21165580 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
ISO BMP2 protein promotes the reaction [tanshinone results in increased phosphorylation of JUN protein]; MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of BMP2 protein] CTD PMID:31306638 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 increases expression ISO tanshinone results in increased expression of CALCOCO2 mRNA CTD PMID:15849732 NCBI chr10:83,935,087...83,963,750 JBrowse link
G Casp3 caspase 3 increases expression
increases activity
ISO tanshinone results in increased expression of CASP3 protein
tanshinone results in increased activity of CASP3 protein
CTD PMID:15849732, PMID:21699893 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] CTD PMID:26203587 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cd33 CD33 molecule decreases expression ISO tanshinone results in decreased expression of CD33 protein CTD PMID:16009009 NCBI chr 1:98,388,811...98,403,539
Ensembl chr 1:98,398,660...98,402,968
JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
ISO 15-deoxyprostaglandin J2 inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]; tanshinone inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; tanshinone inhibits the reaction [Troglitazone results in increased expression of CD36 mRNA]; Troglitazone inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]
tanshinone results in decreased expression of CD36 mRNA; tanshinone results in decreased expression of CD36 protein
CTD PMID:20854809 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd68 Cd68 molecule decreases expression ISO tanshinone results in decreased expression of CD68 protein CTD PMID:20854809 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:32097614 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [tanshinone co-treated with indirubin] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of CDK2 protein]; [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased expression of CDK2 protein] CTD PMID:18344322 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tanshinone results in increased expression of CDKN1A mRNA CTD PMID:15849732 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO indirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]; tanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]; tetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]] CTD PMID:18344322 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 decreases expression ISO tanshinone results in decreased expression of CEACAM6 mRNA CTD PMID:15849732 NCBI chr 1:81,683,500...81,701,230
Ensembl chr 1:81,683,463...81,701,317
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPA protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPA protein] CTD PMID:18344322 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO tanshinone results in increased expression of CEBPB protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPB protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPB protein]
CTD PMID:18344322 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPE protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPE protein] CTD PMID:18344322 NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO tanshinone results in increased expression of CFLAR protein CTD PMID:26203587 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Clu clusterin increases expression ISO tanshinone results in increased expression of CLU mRNA CTD PMID:15849732 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO tanshinone results in decreased expression of COL6A1 mRNA CTD PMID:15849732 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Cst6 cystatin E/M increases expression ISO tanshinone results in increased expression of CST6 mRNA CTD PMID:15849732 NCBI chr 1:220,727,292...220,729,000
Ensembl chr 1:220,727,292...220,729,000
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO tanshinone results in increased expression of CTNNB1 mRNA CTD PMID:25186638 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO tanshinone results in increased expression of CYP1A1 mRNA; tanshinone results in increased expression of CYP1A1 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
CTD PMID:15849732, PMID:16955220, PMID:21262253 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO tanshinone results in increased expression of CYP1A2 mRNA; tanshinone results in increased expression of CYP1A2 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]
CTD PMID:21262253 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO tanshinone results in decreased activity of CYP2C19 protein CTD PMID:25686904 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO tanshinone results in decreased activity of CYP2C8 protein CTD PMID:29689254 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Dck deoxycytidine kinase increases expression ISO tanshinone results in increased expression of DCK mRNA CTD PMID:15849732 NCBI chr14:20,935,442...20,952,939
Ensembl chr14:20,935,369...20,953,095
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]
tanshinone results in increased expression of DDIT3 mRNA; tanshinone results in increased expression of DDIT3 protein
CTD PMID:26203587 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in decreased expression of DUSP1 protein] CTD PMID:29906494 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp11 dual specificity phosphatase 11 increases expression ISO tanshinone results in increased expression of DUSP11 mRNA CTD PMID:15849732 NCBI chr 4:117,617,640...117,631,674
Ensembl chr 4:117,617,533...117,631,716
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO tanshinone results in increased expression of DUSP5 mRNA CTD PMID:15849732 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 decreases expression ISO tanshinone results in decreased expression of DYRK4 mRNA CTD PMID:15849732 NCBI chr 4:159,426,447...159,467,973
Ensembl chr 4:159,427,340...159,467,955
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:28985491 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:28985491 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of EDNRB protein] CTD PMID:28985491 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases response to substance
decreases expression
ISO ELK1 mRNA results in decreased susceptibility to tanshinone
tanshinone results in decreased expression of ELK1 mRNA
CTD PMID:30506648 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO tanshinone results in increased expression of ENC1 mRNA CTD PMID:15849732 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression
multiple interactions
ISO tanshinone results in decreased expression of ERCC1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA]
CTD PMID:21165580 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO tanshinone results in decreased expression of ETS2 mRNA CTD PMID:15849732 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495
JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression ISO tanshinone results in increased expression of F2RL1 mRNA CTD PMID:15849732 NCBI chr 2:25,222,324...25,235,275
Ensembl chr 2:25,222,328...25,235,275
JBrowse link
G Flad1 flavin adenine dinucleotide synthetase 1 increases expression ISO tanshinone results in increased expression of FLAD1 mRNA CTD PMID:15849732 NCBI chr 2:188,726,994...188,736,462
Ensembl chr 2:188,726,994...188,736,462
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] CTD PMID:32097614 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO tanshinone results in increased expression of FOS protein CTD PMID:16009009 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gba glucosylceramidase beta increases expression ISO tanshinone results in increased expression of GBA mRNA CTD PMID:15849732 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO tanshinone results in increased expression of GFAP mRNA; tanshinone results in increased expression of GFAP protein CTD PMID:16955220 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Grb7 growth factor receptor bound protein 7 increases expression ISO tanshinone results in increased expression of GRB7 mRNA CTD PMID:15849732 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanshinone results in decreased expression of GSK3B mRNA CTD PMID:25186638 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO tanshinone results in decreased expression of GSTP1 mRNA CTD PMID:21165580 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H1f2 H1.2 linker histone, cluster member multiple interactions ISO [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tanshinone promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein] CTD PMID:18344322 NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] CTD PMID:18344322 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac3 histone deacetylase 3 increases expression ISO tanshinone results in increased expression of HDAC3 mRNA CTD PMID:15849732 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
tanshinone results in increased expression of HMOX1 protein
tanshinone promotes the reaction [Silicon Dioxide results in increased expression of HMOX1 protein]
CTD PMID:19356721, PMID:32097614 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO tanshinone results in increased expression of ID2 mRNA CTD PMID:15849732 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:29906494 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 increases expression ISO tanshinone results in increased expression of INPPL1 mRNA CTD PMID:15849732 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO tanshinone results in increased expression of ISG20 mRNA CTD PMID:15849732 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO tanshinone results in decreased expression of ITGA6 mRNA CTD PMID:15849732 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO tanshinone results in increased expression of ITGAM protein CTD PMID:16009009 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
ISO BMP2 protein promotes the reaction [tanshinone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased phosphorylation of JUN protein] CTD PMID:31306638 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance
decreases expression
ISO KRAS mRNA results in decreased susceptibility to tanshinone
tanshinone results in decreased expression of KRAS mRNA; tanshinone results in decreased expression of KRAS protein
CTD PMID:30506648 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression
multiple interactions
ISO tanshinone results in decreased expression of LRP1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]
CTD PMID:21165580 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrp5 LDL receptor related protein 5 decreases expression ISO tanshinone results in decreased expression of LRP5 mRNA CTD PMID:15849732 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Lrp8 LDL receptor related protein 8 decreases expression ISO tanshinone results in decreased expression of LRP8 mRNA CTD PMID:15849732 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641
JBrowse link
G Maob monoamine oxidase B increases expression ISO tanshinone results in increased expression of MAOB mRNA CTD PMID:15849732 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO tanshinone results in decreased expression of MAP3K1 mRNA CTD PMID:15849732 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:29906494 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:29906494 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mipep mitochondrial intermediate peptidase decreases expression ISO tanshinone results in decreased expression of MIPEP mRNA CTD PMID:15849732 NCBI chr15:41,084,180...41,192,621
Ensembl chr15:41,084,206...41,190,005
JBrowse link
G Mir322 microRNA 322 multiple interactions
decreases expression
ISO MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of BMP2 protein]; MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]; MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of SP7 protein]
tanshinone results in decreased expression of MIR322 mRNA
CTD PMID:31306638 NCBI chr  X:158,148,161...158,148,255
Ensembl chr  X:158,148,161...158,148,255
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO tanshinone results in decreased expression of MMP7 mRNA CTD PMID:15849732 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA] CTD PMID:24929186 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msr1 macrophage scavenger receptor 1 decreases expression ISO tanshinone results in decreased expression of MSR1 mRNA CTD PMID:20854809 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO tanshinone results in increased expression of MYBL2 mRNA CTD PMID:15849732 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO tanshinone results in decreased expression of MYC protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC mRNA]; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC protein]
tanshinone results in decreased expression of MYC mRNA; tanshinone results in decreased expression of MYC protein
CTD PMID:16009009, PMID:18344322, PMID:21699893 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl1 myosin, light chain 1 increases expression ISO tanshinone results in increased expression of MYL1 mRNA CTD PMID:15849732 NCBI chr 9:73,937,820...73,958,480
Ensembl chr 9:73,937,823...73,958,480
JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit increases expression ISO tanshinone results in increased expression of NAA10 mRNA CTD PMID:15849732 NCBI chr  X:156,863,655...156,868,950
Ensembl chr  X:156,863,754...156,868,950
JBrowse link
G Nanog Nanog homeobox multiple interactions
increases expression
EXP
ISO
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of NANOG protein]
tanshinone results in increased expression of NANOG mRNA
CTD PMID:25186638, PMID:31108107 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 increases expression ISO tanshinone results in increased expression of NDUFB2 mRNA CTD PMID:15849732 NCBI chr 4:67,378,188...67,385,267
Ensembl chr 4:67,378,188...67,385,266
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 increases expression ISO tanshinone results in increased expression of NDUFV1 mRNA CTD PMID:15849732 NCBI chr 1:219,254,293...219,259,328
Ensembl chr 1:219,254,279...219,259,448
JBrowse link
G Nes nestin decreases expression ISO tanshinone results in decreased expression of NES mRNA; tanshinone results in decreased expression of NES protein CTD PMID:16955220 NCBI chr 2:187,343,109...187,352,972
Ensembl chr 2:187,344,056...187,352,969
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein] CTD PMID:32097614 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD PMID:29906494, PMID:30268796 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] CTD PMID:23500011, PMID:24239652, PMID:29906494 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of NOS3 mRNA
tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]
CTD PMID:15849732, PMID:28985491 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NQO1 protein] CTD PMID:32097614 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO tanshinone results in increased activity of NR1I2 protein
NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]
CTD PMID:18805405 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 decreases expression ISO tanshinone results in decreased expression of OLR1 mRNA; tanshinone results in decreased expression of OLR1 protein CTD PMID:22677363 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein] CTD PMID:26203587 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases expression ISO tanshinone results in increased expression of PARP4 mRNA CTD PMID:15849732, PMID:16955220 NCBI chr15:36,809,362...36,911,167 JBrowse link
G Pcsk7 proprotein convertase subtilisin/kexin type 7 increases expression ISO tanshinone results in increased expression of PCSK7 mRNA CTD PMID:15849732 NCBI chr 8:50,200,069...50,222,655
Ensembl chr 8:50,200,069...50,222,630
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression
multiple interactions
EXP tanshinone results in increased expression of PHGDH mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in increased methylation of PHGDH promoter]
CTD PMID:31108107 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO tanshinone results in decreased expression of PLOD2 mRNA CTD PMID:15849732 NCBI chr 8:99,977,334...100,059,736
Ensembl chr 8:99,977,334...100,059,736
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of POU5F1 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of POU5F1 protein]
CTD PMID:25186638, PMID:31108107 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO tanshinone results in decreased expression of PPARG mRNA CTD PMID:20854809 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 multiple interactions ISO [tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 protein CTD PMID:18344322 NCBI chr 7:18,507,878...18,516,321
Ensembl chr 7:18,510,354...18,515,503
JBrowse link
G Prpf6 pre-mRNA processing factor 6 decreases expression ISO tanshinone results in decreased expression of PRPF6 mRNA CTD PMID:15849732 NCBI chr 3:177,098,137...177,162,937
Ensembl chr 3:177,098,073...177,162,916
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression ISO tanshinone results in increased expression of PSMB5 mRNA CTD PMID:15849732 NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659
JBrowse link
G Psmd2 proteasome 26S subunit, non-ATPase 2 increases expression ISO tanshinone results in increased expression of PSMD2 mRNA CTD PMID:15849732 NCBI chr11:83,934,098...83,944,725
Ensembl chr11:83,934,087...83,944,763
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tanshinone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]
tanshinone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:22288910, PMID:23500011, PMID:24239652, PMID:24967690 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression ISO tanshinone results in decreased expression of PTPRK mRNA CTD PMID:15849732 NCBI chr 1:17,445,052...18,058,266
Ensembl chr 1:17,446,417...18,058,055
JBrowse link
G Ptx3 pentraxin 3 decreases secretion
decreases expression
multiple interactions
ISO tanshinone results in decreased secretion of PTX3 protein
tanshinone results in decreased expression of PTX3 mRNA
tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein]
CTD PMID:30268796 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Rarb retinoic acid receptor, beta increases expression
multiple interactions
ISO tanshinone results in increased expression of RARB mRNA
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]; [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]
CTD PMID:18344322 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein; [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased phosphorylation of RB1 protein; [tanshinone co-treated with indirubin] results in increased expression of RB1 protein; [tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein
tanshinone results in increased expression of RB1 protein
CTD PMID:18344322 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein] CTD PMID:30268796 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoc ras homolog family member C increases expression ISO tanshinone results in increased expression of RHOC mRNA CTD PMID:15849732 NCBI chr 2:207,271,692...207,278,010
Ensembl chr 2:207,271,853...207,279,314
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
ISO tanshinone results in increased expression of RUNX2 protein
MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]
CTD PMID:31306638 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sephs2 selenophosphate synthetase 2 increases expression ISO tanshinone results in increased expression of SEPHS2 mRNA CTD PMID:15849732 NCBI chr 1:198,719,158...198,721,476
Ensembl chr 1:198,719,162...198,721,476
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad7 SMAD family member 7 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein] CTD PMID:32097614 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of SOX2 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of SOX2 protein]
CTD PMID:25186638, PMID:31108107 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sp2 Sp2 transcription factor decreases expression ISO tanshinone results in decreased expression of SP2 mRNA CTD PMID:15849732 NCBI chr10:84,890,930...84,920,886
Ensembl chr10:84,890,932...84,920,886
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions
increases expression
ISO MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of SP7 protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of SP7 protein] CTD PMID:31306638 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP tanshinone inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tesk1 testis associated actin remodelling kinase 1 increases expression ISO tanshinone results in increased expression of TESK1 mRNA CTD PMID:15849732 NCBI chr 5:58,937,615...58,943,358
Ensembl chr 5:58,937,615...58,943,358
JBrowse link
G Tfap4 transcription factor AP-4 decreases expression ISO tanshinone results in decreased expression of TFAP4 mRNA CTD PMID:15849732 NCBI chr10:11,204,616...11,222,975
Ensembl chr10:11,206,226...11,223,370
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein] CTD PMID:32097614 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO tanshinone results in increased expression of TK1 mRNA CTD PMID:15849732 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]; tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein] CTD PMID:29906494, PMID:30268796 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein]
tanshinone results in increased susceptibility to TNFSF10 protein
CTD PMID:26203587 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
ISO tanshinone results in increased expression of TP53 protein
tanshinone results in decreased expression of TP53 protein
CTD PMID:16009009, PMID:19885617, PMID:20369472 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO tanshinone results in increased expression of VEGFA mRNA CTD PMID:25186638 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:32097614 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 increases expression ISO tanshinone results in increased expression of WFDC2 mRNA CTD PMID:15849732 NCBI chr 3:161,018,497...161,045,469
Ensembl chr 3:161,018,511...161,024,209
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      atom 19788
        nonmetal atom 19662
          carbon atom 19560
            organic molecular entity 19560
              organic fundamental parent 17773
                natural product fundamental parent 12805
                  terpenoid fundamental parent 1958
                    abietane 191
                      abietadiene + 0
                      abietane diterpenoid + 191
                      abietatriene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19420
                        hydrogen molecular entity 19411
                          hydrides 18460
                            organic hydride 17773
                              organic fundamental parent 17773
                                hydrocarbon 17294
                                  terpene 9607
                                    diterpene 8436
                                      abietane 191
                                        abietadiene + 0
                                        abietane diterpenoid + 191
                                        abietatriene 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.