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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:abietane
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Accession:CHEBI:35673 term browser browse the term
Definition:A diterpene that has formula C20H36.
Synonyms:related_synonym: Formula=C20H36;   InChI=1S/C20H36/c1-14(2)15-7-9-17-16(13-15)8-10-18-19(3,4)11-6-12-20(17,18)5/h14-18H,6-13H2,1-5H3/t15-,16-,17-,18-,20+/m0/s1;   InChIKey=STIVVCHBLMGYSL-ZYNAIFEFSA-N;   SMILES=[H][C@@]12CC[C@@]3([H])C(C)(C)CCC[C@]3(C)[C@@]1([H])CC[C@@H](C2)C(C)C
 xref: Beilstein:2500550



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abietic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin] CTD PMID:16904803 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide] CTD PMID:18436619 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO abietic acid results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO abietic acid results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO abietic acid results in increased expression of GCLM mRNA CTD PMID:27965148 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
carnosic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
decreases phosphorylation
ISO salvin results in increased phosphorylation of AKT1 protein
salvin results in decreased phosphorylation of AKT1 protein
CTD PMID:25178877 PMID:25271104 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] CTD PMID:29854073 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
decreases phosphorylation
ISO salvin promotes the reaction [arsenic trioxide results in decreased phosphorylation of BAD protein]
salvin results in increased expression of BAD protein
salvin results in decreased phosphorylation of BAD protein
CTD PMID:23239002 PMID:28918123 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO salvin inhibits the reaction [Paraquat results in increased expression of BAX protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]
salvin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
salvin results in increased expression of BAX protein
CTD PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]
salvin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]
salvin results in decreased expression of BCL2 protein
Acetylcysteine inhibits the reaction [salvin results in decreased expression of BCL2 protein]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Paraquat results in decreased expression of BCL2 protein]; salvin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]
CTD PMID:25446857 PMID:26577515 PMID:26686574 PMID:28918123 PMID:29854073 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l2 Bcl2-like 2 multiple interactions ISO salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of BCL2L2 protein] CTD PMID:24557422 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP3 protein]
salvin results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP3 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP3 mRNA]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]; salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP3 protein]
CTD PMID:24557422 PMID:25271104 PMID:25446857 PMID:26577515 PMID:26686574 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
ISO Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP8 protein]
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP8 protein]
CTD PMID:28918123 PMID:29854073 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
increases cleavage
ISO salvin results in increased activity of CASP9 protein
salvin inhibits the reaction [sodium arsenite results in increased cleavage of CASP9 protein]
salvin results in increased cleavage of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of CASP9 protein]; salvin inhibits the reaction [Acrylamide results in increased expression of CASP9 mRNA]; salvin inhibits the reaction [Paraquat results in increased activity of CASP9 protein]; salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]; salvin promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]
CTD PMID:23239002 PMID:26577515 PMID:26686574 PMID:28159594 PMID:28918123 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO salvin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of CAT mRNA]
salvin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
CTD PMID:28159594 PMID:29854073 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [salvin co-treated with Tretinoin] results in increased expression of CD14 protein; salvin promotes the reaction [Calcitriol results in increased expression of CD14 protein] CTD PMID:11504768 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO salvin results in increased expression of CDKN1B protein
salvin promotes the reaction [arsenic trioxide results in increased expression of CDKN1B protein]
CTD PMID:23239002 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of FAS protein] CTD PMID:29854073 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO salvin inhibits the reaction [Oxidopamine results in increased expression of FIS1 protein] CTD PMID:31705926 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
salvin results in increased expression of GCLC mRNA
salvin results in increased expression of GCLC protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLC protein]
CTD PMID:18329808 PMID:25446857 PMID:26577515 PMID:26686574 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
salvin results in increased expression of GCLM protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of GCLM mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GCLM protein]
CTD PMID:25446857 PMID:26577515 PMID:26686574 PMID:28159594 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO salvin inhibits the reaction [sodium arsenite results in increased expression of GPT protein] CTD PMID:29854073 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO salvin inhibits the reaction [Acrylamide results in decreased expression of GPX1 mRNA] CTD PMID:28159594 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
salvin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]
salvin results in increased expression of GSR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSR protein]
CTD PMID:25446857 PMID:26577515 PMID:26686574 PMID:29854073 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP
ISO
salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]
salvin results in increased expression of GSTP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSTP1 protein]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; GSTP1 mutant form inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]; salvin results in increased expression of and results in increased activity of GSTP1 protein
CTD PMID:25271104 PMID:26577515 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO salvin results in increased expression of HMOX1 mRNA; salvin results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]
CTD PMID:18329808 PMID:23942037 PMID:26686574 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions ISO salvin inhibits the reaction [IFNG protein results in increased abundance of Nitrites] CTD PMID:23942037 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma multiple interactions
increases ubiquitination
ISO PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein] CTD PMID:31705926 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [salvin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGAM protein; salvin promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; salvin promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:11504768 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]
salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]
CTD PMID:25446857 PMID:29854073 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP salvin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK9 protein] CTD PMID:25446857 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO salvin inhibits the reaction [Oxidopamine results in decreased expression of MFN2 protein] CTD PMID:31705926 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO salvin results in decreased phosphorylation of MTOR protein CTD PMID:25178877 PMID:28918123 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
multiple interactions
ISO salvin results in increased activity of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased activity of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSR protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of GSTP1 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GCLM protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of GSR protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin affects the localization of and results in increased activity of NFE2L2 protein; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 mRNA]; salvin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 protein]
CTD PMID:26577515 PMID:26686574 PMID:28159594 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of NFKBIA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased phosphorylation of NFKBIA protein]; salvin results in increased phosphorylation of and results in increased degradation of NFKBIA protein
CTD PMID:21375325 PMID:25271104 PMID:29854073 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:21375325 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO salvin results in increased expression of NQO1 mRNA
salvin results in increased expression of NQO1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of NQO1 protein]; salvin inhibits the reaction [Acrylamide results in decreased expression of NQO1 mRNA]
CTD PMID:18329808 PMID:26686574 PMID:28159594 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions
increases expression
ISO OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 protein] CTD PMID:31705926 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases cleavage
ISO
EXP
Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; OPA1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]
salvin results in decreased expression of PARP1 protein
CTD PMID:25446857 PMID:28918123 PMID:30707903 PMID:31705926 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of CASP3 protein]]; PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PINK1 protein] CTD PMID:30707903 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO salvin results in increased activity of PPARG protein CTD PMID:20696231 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
increases expression
ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]]; PRKN protein affects the reaction [salvin results in increased expression of OPA1 protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; PRKN protein affects the reaction [salvin results in increased ubiquitination of IKBKG protein]; salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]
salvin results in increased expression of PRKN protein
CTD PMID:30707903 PMID:31705926 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO salvin promotes the reaction [arsenic trioxide results in increased expression of PTEN mRNA]
salvin results in increased expression of PTEN mRNA
CTD PMID:23239002 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:21375325 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein CTD PMID:11504768 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
affects localization
ISO salvin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; salvin inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of RELA protein]
salvin results in increased expression of RELA protein
salvin affects the localization of RELA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin affects the localization of RELA protein]; PRKN protein affects the reaction [salvin results in increased expression of RELA protein]; salvin results in increased expression of and results in increased activity of RELA protein
CTD PMID:21375325 PMID:25271104 PMID:29854073 PMID:31705926 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rxra retinoid X receptor alpha increases expression
multiple interactions
ISO salvin results in increased expression of RXRA protein
Calcitriol promotes the reaction [salvin results in increased expression of RXRA protein]; Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein]
CTD PMID:11504768 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases expression
decreases expression
ISO salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of SHC1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein]
salvin results in increased expression of SHC1 mRNA
CTD PMID:24557422 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
ISO Niacinamide inhibits the reaction [salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [salvin results in decreased expression of SHC1 protein]
salvin results in increased expression of SIRT1 mRNA; salvin results in increased expression of SIRT1 protein
CTD PMID:24557422 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP
salvin inhibits the reaction [Acrylamide results in decreased expression of SOD1 mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of SOD1 protein] CTD PMID:25446857 PMID:28159594 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 mutant form inhibits the reaction [salvin results in increased expression of SOD2 protein]; NFE2L2 protein promotes the reaction [salvin results in increased expression of SOD2 protein]; salvin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased expression of SOD2 protein] CTD PMID:24557422 PMID:26577515 PMID:26686574 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:25446857 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO salvin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21375325 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tyr tyrosinase decreases expression ISO salvin results in decreased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of VDAC1 protein]]; salvin inhibits the reaction [Oxidopamine results in decreased expression of and results in decreased ubiquitination of VDAC1 protein] CTD PMID:30707903 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression
ISO Calcitriol promotes the reaction [salvin results in increased expression of VDR protein]; Tetradecanoylphorbol Acetate promotes the reaction [salvin results in increased expression of VDR protein]; Tretinoin promotes the reaction [salvin results in increased expression of VDR protein] CTD PMID:11504768 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
Cryptotanshinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of ACHE protein CTD PMID:20350537 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO cryptotanshinone binds to and results in decreased activity of BCHE protein CTD PMID:20350537 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Casp3 caspase 3 increases cleavage
increases activity
multiple interactions
ISO cryptotanshinone results in increased cleavage of CASP3 protein
cryptotanshinone results in increased activity of CASP3 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [cryptotanshinone results in increased cleavage of CASP3 protein]
CTD PMID:26564229 PMID:28600121 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO cryptotanshinone results in increased activity of CASP7 protein CTD PMID:26564229 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp9 caspase 9 increases activity ISO cryptotanshinone results in increased activity of CASP9 protein CTD PMID:26564229 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of CDH1 protein] CTD PMID:30208247 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of CTNNB1 protein] CTD PMID:30208247 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]
cryptotanshinone results in increased expression of CYP1A1 mRNA; cryptotanshinone results in increased expression of CYP1A1 protein
CTD PMID:21262253 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO cryptotanshinone results in increased expression of CYP1A2 mRNA; cryptotanshinone results in increased expression of CYP1A2 protein
cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; cryptotanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]
CTD PMID:21262253 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO cryptotanshinone results in increased expression of CYP3A4 protein CTD PMID:18805405 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of EGFR protein modified form] CTD PMID:30208247 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in decreased expression of GSK3B protein] CTD PMID:30208247 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog promotes the reaction [cryptotanshinone results in increased expression of MAP1LC3B protein]; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein] CTD PMID:28600121 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; cryptotanshinone results in increased degradation of and results in increased phosphorylation of NFKBIA protein CTD PMID:28600121 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO cryptotanshinone results in increased activity of NR1I2 protein CTD PMID:18805405 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO cryptotanshinone results in increased cleavage of PARP1 protein CTD PMID:26564229 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER2 protein] CTD PMID:30208247 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO cryptotanshinone inhibits the reaction [Dinoprostone results in increased expression of PTGER4 protein] CTD PMID:30208247 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases activity ISO cryptotanshinone results in decreased activity of PTPN1 protein CTD PMID:29031618 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 PMID:28600121 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein] CTD PMID:28600121 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO cryptotanshinone results in decreased phosphorylation of STAT3 protein CTD PMID:28578322 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cryptotanshinone inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:26564229 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO cryptotanshinone results in decreased expression of TOP2A mRNA
cryptotanshinone results in decreased expression of and results in decreased activity of TOP2A protein
CTD PMID:28716507 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO cryptotanshinone results in decreased expression of TOP2B mRNA CTD PMID:28716507 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
Dihydrotanshinone I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO dihydrotanshinone I binds to and results in increased activity of AHR protein; dihydrotanshinone I promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO dihydrotanshinone I results in increased phosphorylation of AKT1 protein CTD PMID:26282490 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp8 caspase 8 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in decreased expression of CASP8 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in decreased expression of CASP8 protein] CTD PMID:29496522 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO dihydrotanshinone I results in increased expression of CYP1A1 mRNA; dihydrotanshinone I results in increased expression of CYP1A1 protein
Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Resveratrol inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]
CTD PMID:21262253 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO dihydrotanshinone I results in increased expression of CYP1A2 mRNA; dihydrotanshinone I results in increased expression of CYP1A2 protein
Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; dihydrotanshinone I promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]; Resveratrol inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]
CTD PMID:21262253 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO dihydrotanshinone I results in decreased activity of CYP2C8 protein CTD PMID:29689254
G Eif4e eukaryotic translation initiation factor 4E decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of EIF4E protein CTD PMID:26282490 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:26282490 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Epo erythropoietin multiple interactions ISO dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] CTD PMID:26282490 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
multiple interactions
ISO dihydrotanshinone I results in decreased expression of HIF1A protein
dihydrotanshinone I inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; dihydrotanshinone I inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; dihydrotanshinone I inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]
CTD PMID:26282490 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of HMGB1 protein] CTD PMID:29496522 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:29496522 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of and results in increased secretion of IL6 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:29496522 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of MAPK1 protein CTD PMID:26282490 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of MAPK3 protein CTD PMID:26282490 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of MLKL protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of MLKL protein] CTD PMID:29496522 NCBI chr19:39,278,123...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of MPO protein] CTD PMID:29496522 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of MTOR protein CTD PMID:26282490 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of NOS2 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:29496522 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of PTGS2 protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:29496522 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of RIPK1 protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of RIPK1 protein] CTD PMID:29496522 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of RIPK3 protein modified form]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of RIPK3 protein] CTD PMID:29496522 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO dihydrotanshinone I results in decreased phosphorylation of RPS6KB1 protein CTD PMID:26282490 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein] CTD PMID:26282490 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO dihydrotanshinone I inhibits the reaction [[Lipopolysaccharides co-treated with benzyloxycarbonyl-valyl-alanyl-aspartic acid] results in increased expression of and results in increased secretion of TNF protein]; dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of TNF protein]; dihydrotanshinone I inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein] CTD PMID:29496522 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; dihydrotanshinone I inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
dihydrotanshinone I results in decreased expression of VEGFA protein
CTD PMID:26282490 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
ferruginol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] CTD PMID:32946155 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Il6 interleukin 6 multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of IL6 protein] CTD PMID:32946155 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased secretion of TNF protein] CTD PMID:32946155 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32946155 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:32946155 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
Miltirone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO miltirone results in decreased activity of CYP2C19 protein CTD PMID:25686904 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
Tanshinone I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression ISO tanshinone results in increased expression of ACADVL mRNA CTD PMID:15849732 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO tanshinone results in increased expression of ACSL1 mRNA CTD PMID:15849732 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:32097614 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tanshinone binds to and results in increased activity of AHR protein; tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO tanshinone results in decreased expression of ALDH1A3 mRNA CTD PMID:15849732 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO tanshinone results in decreased expression of ALDH3A2 mRNA CTD PMID:15849732 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Apoc1 apolipoprotein C1 increases expression ISO tanshinone results in increased expression of APOC1 mRNA CTD PMID:15849732 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
JBrowse link
G Apom apolipoprotein M increases expression ISO tanshinone results in increased expression of APOM mRNA CTD PMID:15849732 NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO [[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [[tetraarsenic tetrasulfide co-treated with tanshinone] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] CTD PMID:18344322 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO tanshinone results in decreased expression of ASNS mRNA CTD PMID:15849732 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO tanshinone results in decreased expression of ASS1 mRNA CTD PMID:15849732 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases expression ISO tanshinone results in increased expression of ATP6V0B mRNA CTD PMID:15849732 NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401
JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression ISO tanshinone results in increased expression of ATP6V1E1 mRNA CTD PMID:15849732 NCBI chr 4:154,022,360...154,044,486
Ensembl chr 4:154,022,358...154,044,584
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tanshinone results in increased expression of BAX protein CTD PMID:21699893 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression ISO tanshinone results in decreased expression of BCKDHB mRNA CTD PMID:15849732 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanshinone results in decreased expression of BCL2 protein CTD PMID:16009009 PMID:19885617 PMID:20369472 PMID:21699893 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO tanshinone results in decreased expression of BIRC3 mRNA CTD PMID:15849732 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO tanshinone results in decreased expression of BIRC5 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of BIRC5 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA]
CTD PMID:21165580 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
ISO BMP2 protein promotes the reaction [tanshinone results in increased phosphorylation of JUN protein]; MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of BMP2 protein] CTD PMID:31306638 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 increases expression ISO tanshinone results in increased expression of CALCOCO2 mRNA CTD PMID:15849732 NCBI chr10:81,055,467...81,069,298 JBrowse link
G Casp3 caspase 3 increases expression
increases activity
ISO tanshinone results in increased expression of CASP3 protein
tanshinone results in increased activity of CASP3 protein
CTD PMID:15849732 PMID:21699893 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] CTD PMID:26203587 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cd33 CD33 molecule decreases expression ISO tanshinone results in decreased expression of CD33 protein CTD PMID:16009009 NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149
JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
ISO 15-deoxyprostaglandin J2 inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]; tanshinone inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; tanshinone inhibits the reaction [Troglitazone results in increased expression of CD36 mRNA]; Troglitazone inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]
tanshinone results in decreased expression of CD36 mRNA; tanshinone results in decreased expression of CD36 protein
CTD PMID:20854809 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd68 Cd68 molecule decreases expression ISO tanshinone results in decreased expression of CD68 protein CTD PMID:20854809 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:32097614 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [tanshinone co-treated with indirubin] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of CDK2 protein]; [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased expression of CDK2 protein] CTD PMID:18344322 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tanshinone results in increased expression of CDKN1A mRNA CTD PMID:15849732 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression
ISO indirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]; tanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]; tetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]] CTD PMID:18344322 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 decreases expression ISO tanshinone results in decreased expression of CEACAM6 mRNA CTD PMID:15849732 NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPA protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPA protein] CTD PMID:18344322 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions
ISO tanshinone results in increased expression of CEBPB protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPB protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPB protein]
CTD PMID:18344322 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPE protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPE protein] CTD PMID:18344322 NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO tanshinone results in increased expression of CFLAR protein CTD PMID:26203587 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Clu clusterin increases expression ISO tanshinone results in increased expression of CLU mRNA CTD PMID:15849732 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO tanshinone results in decreased expression of COL6A1 mRNA CTD PMID:15849732 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Cst6 cystatin E/M increases expression ISO tanshinone results in increased expression of CST6 mRNA CTD PMID:15849732 NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030
JBrowse link
G Ctnnb1 catenin beta 1 increases expression ISO tanshinone results in increased expression of CTNNB1 mRNA CTD PMID:25186638 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO tanshinone results in increased expression of CYP1A1 mRNA; tanshinone results in increased expression of CYP1A1 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
CTD PMID:15849732 PMID:16955220 PMID:21262253 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO tanshinone results in increased expression of CYP1A2 mRNA; tanshinone results in increased expression of CYP1A2 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]
CTD PMID:21262253 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO tanshinone results in decreased activity of CYP2C19 protein CTD PMID:25686904 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO tanshinone results in decreased activity of CYP2C8 protein CTD PMID:29689254
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dck deoxycytidine kinase increases expression ISO tanshinone results in increased expression of DCK mRNA CTD PMID:15849732 NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]
tanshinone results in increased expression of DDIT3 mRNA; tanshinone results in increased expression of DDIT3 protein
CTD PMID:26203587 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in decreased expression of DUSP1 protein] CTD PMID:29906494 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp11 dual specificity phosphatase 11 increases expression ISO tanshinone results in increased expression of DUSP11 mRNA CTD PMID:15849732 NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO tanshinone results in increased expression of DUSP5 mRNA CTD PMID:15849732 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 decreases expression ISO tanshinone results in decreased expression of DYRK4 mRNA CTD PMID:15849732 NCBI chr 4:159,715,658...159,757,660
Ensembl chr 4:159,715,417...159,757,627
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:28985491 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:28985491 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of EDNRB protein] CTD PMID:28985491 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases response to substance
decreases expression
ISO ELK1 mRNA results in decreased susceptibility to tanshinone
tanshinone results in decreased expression of ELK1 mRNA
CTD PMID:30506648 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO tanshinone results in increased expression of ENC1 mRNA CTD PMID:15849732 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression
multiple interactions
ISO tanshinone results in decreased expression of ERCC1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA]
CTD PMID:21165580 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO tanshinone results in decreased expression of ETS2 mRNA CTD PMID:15849732 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression ISO tanshinone results in increased expression of F2RL1 mRNA CTD PMID:15849732 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Flad1 flavin adenine dinucleotide synthetase 1 increases expression ISO tanshinone results in increased expression of FLAD1 mRNA CTD PMID:15849732 NCBI chr 2:174,819,451...174,828,921
Ensembl chr 2:174,819,453...174,828,977
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] CTD PMID:32097614 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO tanshinone results in increased expression of FOS protein CTD PMID:16009009 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gba glucosylceramidase beta increases expression ISO tanshinone results in increased expression of GBA mRNA CTD PMID:15849732 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO tanshinone results in increased expression of GFAP mRNA; tanshinone results in increased expression of GFAP protein CTD PMID:16955220 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Grb7 growth factor receptor bound protein 7 increases expression ISO tanshinone results in increased expression of GRB7 mRNA CTD PMID:15849732 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanshinone results in decreased expression of GSK3B mRNA CTD PMID:25186638 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO tanshinone results in decreased expression of GSTP1 mRNA CTD PMID:21165580 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G H1f2 H1.2 linker histone, cluster member multiple interactions ISO [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tanshinone promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein] CTD PMID:18344322 NCBI chr17:41,391,106...41,392,611 JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] CTD PMID:18344322 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac3 histone deacetylase 3 increases expression ISO tanshinone results in increased expression of HDAC3 mRNA CTD PMID:15849732 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
tanshinone results in increased expression of HMOX1 protein
tanshinone promotes the reaction [Silicon Dioxide results in increased expression of HMOX1 protein]
CTD PMID:19356721 PMID:32097614 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO tanshinone results in increased expression of ID2 mRNA CTD PMID:15849732 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:29906494 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 increases expression ISO tanshinone results in increased expression of INPPL1 mRNA CTD PMID:15849732 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO tanshinone results in increased expression of ISG20 mRNA CTD PMID:15849732 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO tanshinone results in decreased expression of ITGA6 mRNA CTD PMID:15849732 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO tanshinone results in increased expression of ITGAM protein CTD PMID:16009009 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
ISO BMP2 protein promotes the reaction [tanshinone results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased phosphorylation of JUN protein] CTD PMID:31306638 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance
decreases expression
ISO KRAS mRNA results in decreased susceptibility to tanshinone
tanshinone results in decreased expression of KRAS mRNA; tanshinone results in decreased expression of KRAS protein
CTD PMID:30506648 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression
multiple interactions
ISO tanshinone results in decreased expression of LRP1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]
CTD PMID:21165580 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Lrp5 LDL receptor related protein 5 decreases expression ISO tanshinone results in decreased expression of LRP5 mRNA CTD PMID:15849732 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Lrp8 LDL receptor related protein 8 decreases expression ISO tanshinone results in decreased expression of LRP8 mRNA CTD PMID:15849732 NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352
JBrowse link
G Maob monoamine oxidase B increases expression ISO tanshinone results in increased expression of MAOB mRNA CTD PMID:15849732 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO tanshinone results in decreased expression of MAP3K1 mRNA CTD PMID:15849732 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:29906494 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:29906494 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mipep mitochondrial intermediate peptidase decreases expression ISO tanshinone results in decreased expression of MIPEP mRNA CTD PMID:15849732 NCBI chr15:34,926,198...35,051,722
Ensembl chr15:34,926,207...35,051,727
JBrowse link
G Mir322 microRNA 322 multiple interactions
decreases expression
ISO MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of BMP2 protein]; MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]; MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of SP7 protein]
tanshinone results in decreased expression of MIR322 mRNA
CTD PMID:31306638 NCBI chr  X:132,806,594...132,806,688 JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO tanshinone results in decreased expression of MMP7 mRNA CTD PMID:15849732 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA] CTD PMID:24929186 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Msr1 macrophage scavenger receptor 1 decreases expression ISO tanshinone results in decreased expression of MSR1 mRNA CTD PMID:20854809 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO tanshinone results in increased expression of MYBL2 mRNA CTD PMID:15849732 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions
ISO tanshinone results in decreased expression of MYC protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC mRNA]; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC protein]
tanshinone results in decreased expression of MYC mRNA; tanshinone results in decreased expression of MYC protein
CTD PMID:16009009 PMID:18344322 PMID:21699893 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl1 myosin, light chain 1 increases expression ISO tanshinone results in increased expression of MYL1 mRNA CTD PMID:15849732 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit increases expression ISO tanshinone results in increased expression of NAA10 mRNA CTD PMID:15849732 NCBI chr  X:151,656,056...151,661,304
Ensembl chr  X:151,656,056...151,661,252
JBrowse link
G Nanog Nanog homeobox multiple interactions
increases expression
EXP
ISO
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of NANOG protein]
tanshinone results in increased expression of NANOG mRNA
CTD PMID:25186638 PMID:31108107 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 increases expression ISO tanshinone results in increased expression of NDUFB2 mRNA CTD PMID:15849732 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 increases expression ISO tanshinone results in increased expression of NDUFV1 mRNA CTD PMID:15849732 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
JBrowse link
G Nes nestin decreases expression ISO tanshinone results in decreased expression of NES mRNA; tanshinone results in decreased expression of NES protein CTD PMID:16955220 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein] CTD PMID:32097614 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD PMID:29906494 PMID:30268796 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] CTD PMID:23500011 PMID:24239652 PMID:29906494 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of NOS3 mRNA
tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]
CTD PMID:15849732 PMID:28985491 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NQO1 protein] CTD PMID:32097614 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO tanshinone results in increased activity of NR1I2 protein
NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]
CTD PMID:18805405 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 decreases expression ISO tanshinone results in decreased expression of OLR1 mRNA; tanshinone results in decreased expression of OLR1 protein CTD PMID:22677363 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein] CTD PMID:26203587 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases expression ISO tanshinone results in increased expression of PARP4 mRNA CTD PMID:15849732 PMID:16955220 NCBI chr15:30,690,503...30,792,868 JBrowse link
G Pcsk7 proprotein convertase subtilisin/kexin type 7 increases expression ISO tanshinone results in increased expression of PCSK7 mRNA CTD PMID:15849732 NCBI chr 8:46,202,079...46,224,699
Ensembl chr 8:46,202,131...46,224,705
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression
multiple interactions
EXP tanshinone results in increased expression of PHGDH mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in increased methylation of PHGDH promoter]
CTD PMID:31108107 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO tanshinone results in decreased expression of PLOD2 mRNA CTD PMID:15849732 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of POU5F1 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of POU5F1 protein]
CTD PMID:25186638 PMID:31108107 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO tanshinone results in decreased expression of PPARG mRNA CTD PMID:20854809 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 multiple interactions ISO [tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 protein CTD PMID:18344322 NCBI chr 7:14,428,548...14,438,081 JBrowse link
G Prpf6 pre-mRNA processing factor 6 decreases expression ISO tanshinone results in decreased expression of PRPF6 mRNA CTD PMID:15849732 NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression ISO tanshinone results in increased expression of PSMB5 mRNA CTD PMID:15849732 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440
JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression ISO tanshinone results in increased expression of PSMD2 mRNA CTD PMID:15849732 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tanshinone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]
tanshinone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD PMID:22288910 PMID:23500011 PMID:24239652 PMID:24967690 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression ISO tanshinone results in decreased expression of PTPRK mRNA CTD PMID:15849732 NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:16,850,576...17,103,605
JBrowse link
G Ptx3 pentraxin 3 decreases secretion
decreases expression
multiple interactions
ISO tanshinone results in decreased secretion of PTX3 protein
tanshinone results in decreased expression of PTX3 mRNA
tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein]
CTD PMID:30268796 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Rarb retinoic acid receptor, beta increases expression
multiple interactions
ISO tanshinone results in increased expression of RARB mRNA
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]; [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]
CTD PMID:18344322 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression
ISO [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein; [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased phosphorylation of RB1 protein; [tanshinone co-treated with indirubin] results in increased expression of RB1 protein; [tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein
tanshinone results in increased expression of RB1 protein
CTD PMID:18344322 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein] CTD PMID:30268796 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoc ras homolog family member C increases expression ISO tanshinone results in increased expression of RHOC mRNA CTD PMID:15849732 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
ISO tanshinone results in increased expression of RUNX2 protein
MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of RUNX2 protein]
CTD PMID:31306638 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sephs2 selenophosphate synthetase 2 increases expression ISO tanshinone results in increased expression of SEPHS2 mRNA CTD PMID:15849732 NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad7 SMAD family member 7 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein] CTD PMID:32097614 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression
multiple interactions
ISO
EXP
tanshinone results in increased expression of SOX2 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of SOX2 protein]
CTD PMID:25186638 PMID:31108107 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Sp2 Sp2 transcription factor decreases expression ISO tanshinone results in decreased expression of SP2 mRNA CTD PMID:15849732 NCBI chr10:81,940,580...81,970,548
Ensembl chr10:81,940,587...81,970,548
JBrowse link
G Sp7 Sp7 transcription factor multiple interactions
increases expression
ISO MIR322 mRNA inhibits the reaction [tanshinone results in increased expression of SP7 protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of SP7 protein] CTD PMID:31306638 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP tanshinone inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tesk1 testis associated actin remodelling kinase 1 increases expression ISO tanshinone results in increased expression of TESK1 mRNA CTD PMID:15849732 NCBI chr 5:57,691,922...57,697,698
Ensembl chr 5:57,691,969...57,697,698
JBrowse link
G Tfap4 transcription factor AP-4 decreases expression ISO tanshinone results in decreased expression of TFAP4 mRNA CTD PMID:15849732 NCBI chr10:11,001,338...11,019,386
Ensembl chr10:11,002,911...11,019,386
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein] CTD PMID:32097614 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO tanshinone results in increased expression of TK1 mRNA CTD PMID:15849732 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]; tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein] CTD PMID:29906494 PMID:30268796 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance
ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein]
tanshinone results in increased susceptibility to TNFSF10 protein
CTD PMID:26203587 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
ISO tanshinone results in increased expression of TP53 protein
tanshinone results in decreased expression of TP53 protein
CTD PMID:16009009 PMID:19885617 PMID:20369472 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO tanshinone results in increased expression of VEGFA mRNA CTD PMID:25186638 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:32097614 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 increases expression ISO tanshinone results in increased expression of WFDC2 mRNA CTD PMID:15849732 NCBI chr 3:153,286,946...153,314,832
Ensembl chr 3:153,286,131...153,292,807
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          carbon atom 19621
            organic molecular entity 19621
              organic fundamental parent 18362
                natural product fundamental parent 13398
                  terpenoid fundamental parent 3515
                    abietane 207
                      abietadiene + 0
                      abietane diterpenoid + 207
                      abietatriene 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    main group molecular entity 19710
                      s-block molecular entity 19492
                        hydrogen molecular entity 19484
                          hydrides 18850
                            organic hydride 18362
                              organic fundamental parent 18362
                                hydrocarbon 18074
                                  terpene 12727
                                    diterpene 11524
                                      abietane 207
                                        abietadiene + 0
                                        abietane diterpenoid + 207
                                        abietatriene 0
paths to the root