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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
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Accession:CHEBI:35664 term browser browse the term
Definition:Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
Synonyms:related_synonym: HMG-CoA reductase inhibitor;   HMG-CoA reductase inhibitors;   hydroxymethylglutaryl-CoA reductase inhibitor;   hydroxymethylglutaryl-CoA reductase inhibitors
 xref: PMID:1464741;   PMID:15531285;   PMID:20467214;   Wikipedia:HMG-CoA_reductase



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atorvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 increases expression ISO atorvastatin co-treated with N-nitrosodiethylamine increases expression of Cdh1 mRNA in liver RGD PMID:25319454 RGD:152995431 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO atorvastatin co-treated with N-nitrosodiethylamine decreases expression of Slco1b2 mRNA in liver RGD PMID:25319454 RGD:152995431 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
cerivastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO cerivastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; cerivastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
cerivastatin results in decreased activity of ABCB11 protein
CTD PMID:15901796 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects export ISO ABCB1 protein affects the export of cerivastatin CTD PMID:15901800 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export ISO ABCC2 protein affects the export of cerivastatin CTD PMID:15901800 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export ISO ABCG2 protein affects the export of cerivastatin CTD PMID:15901800 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases secretion ISO cerivastatin results in increased secretion of BMP2 protein CTD PMID:16470222 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO cerivastatin results in increased activity of CASP3 protein
geranylgeranyl pyrophosphate inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]; Mevalonic Acid inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]
CTD PMID:15705602 PMID:16470222 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO cerivastatin results in increased activity of CASP8 protein CTD PMID:15705602 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO cerivastatin results in increased activity of CASP9 protein CTD PMID:15705602 PMID:16470222 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; cerivastatin results in decreased expression of and results in decreased secretion of CCL2 protein; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]
cerivastatin results in decreased expression of CCL2 mRNA
CTD PMID:12117737 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO cerivastatin results in increased expression of CYP2B6 mRNA CTD PMID:15802384 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects response to substance
increases metabolic processing
ISO CYP2C8 gene mutant form affects the susceptibility to cerivastatin
CYP2C8 protein results in increased metabolism of cerivastatin
CTD PMID:12464242 PMID:15365880 PMID:15716363
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of cerivastatin CTD PMID:15365880 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases localization ISO cerivastatin results in increased localization of DIABLO protein CTD PMID:15705602 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 multiple interactions ISO cerivastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
JBrowse link
G F2 coagulation factor II multiple interactions ISO cerivastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein] CTD PMID:12067895 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP cerivastatin results in decreased expression of FGF2 mRNA; cerivastatin results in decreased expression of FGF2 protein CTD PMID:11479256 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO cerivastatin inhibits the reaction [TNF results in increased expression of ICAM1] CTD PMID:12615677 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP cerivastatin results in decreased expression of IL1B CTD PMID:12878482 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; cerivastatin results in decreased expression of and results in decreased secretion of IL6 protein; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]
cerivastatin results in decreased expression of IL6
cerivastatin results in decreased expression of IL6 mRNA
CTD PMID:11479256 PMID:12117737 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgal integrin subunit alpha L multiple interactions ISO cerivastatin inhibits the reaction [TNF results in increased expression of ITGAL] CTD PMID:12615677 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO cerivastatin inhibits the reaction [TNF results in increased expression of ITGB2] CTD PMID:12615677 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Mb myoglobin increases secretion EXP cerivastatin results in increased secretion of MB protein CTD PMID:19628585 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO cerivastatin results in increased activity of NR1I2 protein CTD PMID:15802384 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases activity
increases activity
ISO
EXP
cerivastatin results in decreased activity of NR1I3 protein alternative form
cerivastatin results in increased activity of NR1I3 protein
CTD PMID:15802384 PMID:21778469 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Rab4a RAB4A, member RAS oncogene family decreases prenylation
affects expression
EXP cerivastatin results in decreased prenylation of RAB4 protein
cerivastatin affects the expression of RAB4A protein
CTD PMID:16239165 NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions
decreases geranoylation
ISO Mevalonic Acid inhibits the reaction [cerivastatin results in decreased geranoylation of RAP1A protein] CTD PMID:25578243 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rhoa ras homolog family member A decreases localization
multiple interactions
ISO cerivastatin results in decreased localization of RHOA protein
cerivastatin results in increased localization of and results in decreased prenylation of RHOA protein
CTD PMID:15705602 PMID:16470222 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; cerivastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]; cerivastatin inhibits the reaction [TNF results in increased expression of ICAM1]; cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]; cerivastatin inhibits the reaction [TNF results in increased expression of ITGAL]; cerivastatin inhibits the reaction [TNF results in increased expression of ITGB2]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] CTD PMID:12117737 PMID:12615677 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnni2 troponin I2, fast skeletal type increases secretion EXP cerivastatin results in increased secretion of TNNI2 protein CTD PMID:19628585 NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560
JBrowse link
fluvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to Fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to Fluvastatin CTD PMID:19773416 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO fluvastatin results in decreased activity of ABCB11 protein
fluvastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
CTD PMID:15901796 PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
EXP
ISO
ABCC2 protein affects the transport of fluvastatin
ABCC2 protein binds to and results in increased uptake of fluvastatin analog; fluvastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; fluvastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:16026004 PMID:23562342 PMID:24909372 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]] CTD PMID:35465754 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:19773416 PMID:20671225 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E multiple interactions
increases expression
ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin
fluvastatin results in increased expression of APOE protein
CTD PMID:8017468 PMID:19773416 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Arhgap29 Rho GTPase activating protein 29 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGAP29 mRNA CTD PMID:16996129 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF12 mRNA CTD PMID:16996129 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNA CTD PMID:16996129 NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]] CTD PMID:35465754 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BCAP29 mRNA CTD PMID:16996129 NCBI chr 6:48,182,702...48,222,698
Ensembl chr 6:48,182,706...48,222,720
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]] CTD PMID:35465754 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BCL2L11 mRNA CTD PMID:16996129 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Becn1 beclin 1 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]] CTD PMID:35465754 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BHLHE40 mRNA CTD PMID:16996129 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of BUB1 mRNA CTD PMID:16996129 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of CASP1 mRNA CTD PMID:16996129 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein; Mevalonic Acid inhibits the reaction [fluvastatin results in increased cleavage of and results in increased activity of CASP3 protein]
Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]
CTD PMID:24964743 PMID:35465754 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO fluvastatin results in increased activity of CASP8 protein
Mevalonic Acid inhibits the reaction [fluvastatin results in increased activity of CASP8 protein]
CTD PMID:24964743 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase increases expression
multiple interactions
ISO
EXP
fluvastatin results in increased expression of CAT protein
Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]
CTD PMID:24964743 PMID:35465754 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of CCL2 mRNA] CTD PMID:16452496 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of CDK2AP2 mRNA CTD PMID:16996129 NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of CKS2 mRNA CTD PMID:16996129 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO fluvastatin results in increased expression of CYP2B6 mRNA CTD PMID:15802384 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions
ISO Fluvastatin results in decreased activity of CYP3A4 protein
[Fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; Fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam]
CTD PMID:16029222 PMID:24204015 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddb2 damage specific DNA binding protein 2 decreases expression
multiple interactions
ISO fluvastatin results in decreased expression of DDB2 mRNA; fluvastatin results in decreased expression of DDB2 protein
[fluvastatin results in decreased expression of DDB2] which results in increased expression of SOD2 mRNA; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of DDB2 protein]
CTD PMID:24964743 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Ednra endothelin receptor type A decreases expression EXP fluvastatin results in decreased expression of EDNRA mRNA CTD PMID:28951255 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Emp3 epithelial membrane protein 3 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of EMP3 mRNA CTD PMID:16996129 NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA CTD PMID:16996129 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Erg ETS transcription factor ERG multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNA CTD PMID:16996129 NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression
ISO Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]]; geranylgeraniol inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 mRNA]; Mevalonic Acid inhibits the reaction [Fluvastatin results in decreased expression of F3 protein]
Fluvastatin results in decreased expression of F3 mRNA; Fluvastatin results in decreased expression of F3 protein
CTD PMID:9081680 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of FDFT1 mRNA CTD PMID:16996129 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of FNTA mRNA CTD PMID:16996129 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO Fluvastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]] CTD PMID:35465754 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions ISO [Fluvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA CTD PMID:24204015 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]] CTD PMID:35465754 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of GADD45B mRNA CTD PMID:16996129 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]] CTD PMID:35465754 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases activity
ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin
fluvastatin results in decreased activity of HMGCR protein
CTD PMID:8593127 PMID:19773416 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]] CTD PMID:35465754 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]] CTD PMID:35465754 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]] CTD PMID:35465754 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IGF1 mRNA CTD PMID:16996129 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IGFBP5 mRNA CTD PMID:16996129 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IL10RA mRNA CTD PMID:16996129 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]] CTD PMID:35465754 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta decreases expression EXP fluvastatin results in decreased expression of IL1B mRNA CTD PMID:28951255 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of IL2RG mRNA CTD PMID:16996129 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO Fluvastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Kat2b lysine acetyltransferase 2B multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of KAT2B mRNA CTD PMID:16996129 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases activity
ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; fluvastatin promotes the reaction [Cholesterol, LDL binds to LDLR protein]; fluvastatin promotes the reaction [Indomethacin promotes the reaction [Cholesterol, LDL binds to LDLR protein]]
fluvastatin results in increased activity of LDLR protein
CTD PMID:8593127 PMID:10395027 PMID:19773416 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]] CTD PMID:35465754 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lipc lipase C, hepatic type multiple interactions ISO [ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lmna lamin A/C decreases farnesylation ISO fluvastatin results in decreased farnesylation of LMNA protein CTD PMID:16996129 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO [ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin; [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of LZTS1 mRNA CTD PMID:16996129 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO fluvastatin results in decreased expression of MCL1 protein CTD PMID:16996129 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Med23 mediator complex subunit 23 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of MED23 mRNA CTD PMID:16996129 NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]] CTD PMID:35465754 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP2 mRNA] CTD PMID:24964743 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO fluvastatin results in decreased expression of MMP9 mRNA
Amitrole inhibits the reaction [fluvastatin results in decreased expression of MMP9 mRNA]
CTD PMID:24964743 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mphosph8 M-phase phosphoprotein 8 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of MPHOSPH8 mRNA CTD PMID:16996129 NCBI chr15:30,800,546...30,828,415
Ensembl chr15:30,686,613...30,828,810
JBrowse link
G Mstn myostatin increases expression ISO Fluvastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,453,982...48,458,809
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]] CTD PMID:35465754 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Ndc80 NDC80 kinetochore complex component multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of NDC80 mRNA CTD PMID:16996129 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]] CTD PMID:35465754 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]] CTD PMID:35465754 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO fluvastatin results in increased expression of NOS2 mRNA; fluvastatin results in increased expression of NOS2 protein
[[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide; [N-(3-(aminomethyl)benzyl)acetamidine results in decreased activity of NOS2 protein] inhibits the reaction [fluvastatin results in increased abundance of Nitric Oxide]; Mevalonic Acid inhibits the reaction [fluvastatin results in increased expression of NOS2 protein]
CTD PMID:24964743 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA CTD PMID:28951255 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression
multiple interactions
ISO
EXP
fluvastatin increases expression of Nphs1 protein in kidney
Fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of NPHS1 mRNA]
CTD
RGD
PMID:16452496 PMID:19188342 RGD:38596324 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO fluvastatin results in increased activity of NR1I2 protein
[Fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA; [Fluvastatin co-treated with NR1I2 protein] results in increased expression of G6PC1 mRNA; [Fluvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA
CTD PMID:15802384 PMID:24204015 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO
EXP
fluvastatin results in increased activity of NR1I3 protein CTD PMID:15802384 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Optn optineurin multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of OPTN mRNA CTD PMID:16996129 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
JBrowse link
G Pals1 protein associated with LIN7 1, MAGUK p55 family member multiple interactions ISO [Zoledronic Acid co-treated with Fluvastatin] results in increased expression of PALS1 mRNA CTD PMID:16996129 NCBI chr 6:97,548,133...97,654,163
Ensembl chr 6:97,548,630...97,653,305
JBrowse link
G Pappa2 pappalysin 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of PAPPA2 mRNA CTD PMID:16996129 NCBI chr13:70,873,918...71,147,874
Ensembl chr13:70,876,794...71,147,779
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 multiple interactions ISO [APOB gene SNP co-treated with APOE gene SNP co-treated with HMGCR gene SNP co-treated with LDLR gene SNP co-treated with PCSK9 gene SNP co-treated with ABCA1 gene SNP co-treated with CETP gene SNP co-treated with LIPC gene SNP co-treated with LPL gene SNP] affects the susceptibility to fluvastatin CTD PMID:19773416 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity
EXP fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
fluvastatin results in decreased activity of PON1 protein
CTD PMID:14668577 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of PPP1R12A protein modified form] CTD PMID:16452496 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of PPP1R15A mRNA CTD PMID:16996129 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of PRDX3 mRNA CTD PMID:16996129 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Procr protein C receptor increases expression ISO fluvastatin results in increased expression of PROCR protein CTD PMID:16142594 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link
G Rab27b RAB27B, member RAS oncogene family multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB27B mRNA CTD PMID:16996129 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
JBrowse link
G Rab32 RAB32, member RAS oncogene family multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB32 mRNA CTD PMID:16996129 NCBI chr 1:4,946,193...4,961,003
Ensembl chr 1:4,945,036...4,960,934
JBrowse link
G Rab5b RAB5B, member RAS oncogene family multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB5B mRNA CTD PMID:16996129 NCBI chr 7:1,109,449...1,128,348
Ensembl chr 7:1,109,454...1,128,268
JBrowse link
G Rabgap1l RAB GTPase activating protein 1-like multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RABGAP1L mRNA CTD PMID:16996129 NCBI chr13:72,464,114...73,059,845
Ensembl chr13:72,468,110...73,059,984
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases prenylation ISO fluvastatin results in decreased prenylation of RAP1A protein CTD PMID:16996129 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO fluvastatin results in decreased phosphorylation of RB1 protein CTD PMID:16996129 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]] CTD PMID:9081680 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Fluvastatin inhibits the reaction [Lipopolysaccharides promotes the reaction [[REL protein binds to RELA protein] which binds to F3 promoter]] CTD PMID:9081680 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs11 regulator of G-protein signaling 11 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RGS11 mRNA CTD PMID:16996129 NCBI chr10:15,222,803...15,231,060
Ensembl chr10:15,222,803...15,231,060
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO
EXP
fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of RHOA protein] CTD PMID:16452496 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RHOB mRNA CTD PMID:16996129 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RIMS2 mRNA CTD PMID:16996129 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Rin2 Ras and Rab interactor 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of RIN2 mRNA CTD PMID:16996129 NCBI chr 3:133,086,858...133,303,604
Ensembl chr 3:133,086,749...133,303,604
JBrowse link
G RT1-Ba RT1 class II, locus Ba affects expression ISO fluvastatin affects the expression of HLA-DQA1 mRNA CTD PMID:25811541 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 affects expression EXP fluvastatin affects the expression of SGK1 mRNA; fluvastatin affects the expression of SGK1 protein CTD PMID:16696316 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions ISO [fluvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA CTD PMID:24204015 NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO fluvastatin results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects import ISO SLCO1B3 protein affects the import of fluvastatin CTD PMID:16046661 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects import ISO SLCO2B1 protein affects the import of fluvastatin CTD PMID:16046661 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO [fluvastatin co-treated with Doxorubicin] results in increased expression of SOD2 protein
fluvastatin results in increased expression of SOD2 mRNA; fluvastatin results in increased expression of SOD2 protein
[fluvastatin results in decreased expression of DDB2] which results in increased expression of SOD2 mRNA; Mevalonic Acid inhibits the reaction [fluvastatin results in increased expression of SOD2 protein]
CTD PMID:19147586 PMID:24964743 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of SOS2 mRNA CTD PMID:16996129 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
JBrowse link
G Spin2a spindlin family member 2A multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of SPIN2A mRNA CTD PMID:16996129 NCBI chr  X:17,511,018...17,513,001
Ensembl chr  X:17,511,022...17,513,001
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of SPP1 mRNA] CTD PMID:16452496 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO fluvastatin results in increased expression of TFPI protein CTD PMID:16142594 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880
JBrowse link
G Tfrc transferrin receptor multiple interactions
decreases expression
ISO [[fluvastatin results in increased expression of NOS2] which results in increased abundance of Nitric Oxide] which results in decreased expression of TFRC; [fluvastatin results in decreased expression of TFRC protein] which results in decreased uptake of Iron; Amitrole inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC mRNA]; Mevalonic Acid inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]; N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [fluvastatin results in decreased expression of TFRC protein]
fluvastatin results in decreased expression of TFRC mRNA; fluvastatin results in decreased expression of TFRC protein
CTD PMID:24964743 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
multiple interactions
EXP fluvastatin affects the expression of TGFB1 protein
Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]
CTD PMID:16696316 PMID:35465754 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNA CTD PMID:16996129 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of TP53INP1 mRNA CTD PMID:16996129 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Vim vimentin multiple interactions EXP fluvastatin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of VIM mRNA] CTD PMID:16452496 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt11 Wnt family member 11 multiple interactions ISO [zoledronic acid co-treated with fluvastatin] results in increased expression of WNT11 mRNA CTD PMID:16996129 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294
JBrowse link
lovastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression
decreases expression
multiple interactions
ISO Lovastatin results in increased expression of ABCA1 mRNA
lovastatin decreases expression of ABCA1 mRNA in HepG2 cells
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCA1 mRNA
Lovastatin results in decreased expression of ABCA1 mRNA
CTD
RGD
PMID:19260826 PMID:29852127 PMID:27765770 RGD:18936994 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Lovastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Lovastatin results in decreased activity of ABCB11 protein
CTD PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity
increases transport
ISO Lovastatin analog inhibits the reaction [ABCB1 protein results in increased transport of calcein AM]
Lovastatin analog results in decreased activity of ABCB1 protein
ABCB1 protein results in increased transport of Lovastatin; ABCB1 protein results in increased transport of Lovastatin analog
CTD PMID:15616150 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
ISO Lovastatin results in decreased activity of ABCC1 protein
[Lovastatin results in decreased activity of ABCC1 protein] which results in increased susceptibility to Antimony Sodium Gluconate; Doxorubicin inhibits the reaction [Lovastatin results in increased expression of ABCC1 mRNA]
CTD PMID:18056276 PMID:22712078 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
decreases activity
ISO
EXP
ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]
Lovastatin results in increased expression of ABCC2 mRNA
Lovastatin analog results in decreased activity of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Lovastatin analog; Lovastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Lovastatin analog inhibits the reaction [ABCC2 protein results in increased transport of calcein AM]; Lovastatin promotes the reaction [Cisplatin results in decreased expression of ABCC2 mRNA]
CTD PMID:15616150 PMID:23562342 PMID:26739623 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects expression
multiple interactions
ISO Lovastatin affects the expression of ABCG5 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ABCG5 mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 affects expression ISO Lovastatin affects the expression of ABCG8 mRNA CTD PMID:27208389 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACACA mRNA CTD PMID:29852127 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACOX1 mRNA CTD PMID:29852127 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of ACSS2 mRNA CTD PMID:29852127 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Lovastatin results in decreased expression of ACTA2 protein
CTD PMID:22129737 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actb actin, beta decreases expression
increases expression
ISO Lovastatin results in decreased expression of ACTB mRNA
Lovastatin results in increased expression of ACTB mRNA
CTD PMID:20493250 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actr3 actin related protein 3 increases expression ISO Lovastatin results in increased expression of ACTR3 mRNA CTD PMID:20493250 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression
multiple interactions
EXP
ISO
Lovastatin results in increased expression of ADAM10 protein
[Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein
CTD PMID:29341888 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing affects expression
multiple interactions
ISO Lovastatin affects the expression of ADIPOQ mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of ADIPOQ mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Lovastatin results in decreased expression of AHCY mRNA CTD PMID:20493250 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G Akap7 A-kinase anchoring protein 7 decreases response to substance ISO AKAP7 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]
Lovastatin results in decreased phosphorylation of AKT1 protein
CTD PMID:16425225 PMID:17472962 PMID:19760159 PMID:20578043 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ank2 ankyrin 2 decreases response to substance ISO ANK2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
JBrowse link
G Anxa4 annexin A4 decreases expression ISO Lovastatin results in decreased expression of ANXA4 mRNA CTD PMID:20493250 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Anxa5 annexin A5 decreases expression ISO Lovastatin results in decreased expression of ANXA5 mRNA CTD PMID:20493250 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [Lovastatin co-treated with Niacin] results in increased expression of APOA1 protein; [Niacin co-treated with Lovastatin] results in increased expression of APOA1 protein CTD PMID:12633795 PMID:17319473 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apob apolipoprotein B multiple interactions
decreases secretion
ISO [Niacin co-treated with Lovastatin] results in decreased expression of APOB protein
Lovastatin results in decreased secretion of APOB protein
CTD PMID:11728391 PMID:12633795 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E affects expression
multiple interactions
ISO Lovastatin affects the expression of APOE mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of APOE mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases cleavage
increases secretion
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; TAPI-2 inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; U 0126 inhibits the reaction [Lovastatin results in increased secretion of APP protein]
[APP protein co-treated with Lovastatin] results in increased secretion of APP protein; [Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein; [Lovastatin co-treated with APP protein] results in increased expression of ADAM10 protein; [Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein; [Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; [Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[APP protein co-treated with Lovastatin] results in increased secretion of APP protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased cleavage of APP protein
Lovastatin results in increased secretion of APP protein; Lovastatin results in increased secretion of APP protein modified form
CTD PMID:19741129 PMID:29341888 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Lovastatin results in increased expression of ARHGDIA mRNA CTD PMID:20493250 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Atm ATM serine/threonine kinase multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATM protein modified form] CTD PMID:26739623 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of ATR protein modified form] CTD PMID:26739623 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Bace1 beta-secretase 1 decreases expression
multiple interactions
EXP
ISO
Lovastatin results in decreased expression of BACE1 protein
[Lovastatin co-treated with APP protein] results in decreased expression of BACE1 protein
CTD PMID:29341888 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bace2 beta-secretase 2 multiple interactions
increases expression
ISO
EXP
[Lovastatin co-treated with APP protein] results in increased expression of BACE2 protein
Lovastatin results in increased expression of BACE2 protein
CTD PMID:29341888 NCBI chr11:36,707,473...36,789,550
Ensembl chr11:36,707,458...36,789,546
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
affects localization
ISO
EXP
Lovastatin results in increased expression of BAX protein
Lovastatin promotes the reaction [Cisplatin results in increased expression of BAX mRNA]
Lovastatin affects the localization of BAX protein
CTD PMID:10473109 PMID:15180944 PMID:26739623 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases cleavage
multiple interactions
EXP Lovastatin results in increased cleavage of BCAR1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of BCAR1 protein]
CTD PMID:16367743 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Lovastatin results in decreased expression of BCL2 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein]
CTD PMID:10473109 PMID:11178870 PMID:12094262 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
EXP Lovastatin results in decreased expression of BCL2L1 protein
Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2L1 protein]
CTD PMID:11178870 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions
increases expression
ISO pyrazolanthrone inhibits the reaction [Lovastatin results in increased expression of BCL2L11 protein] CTD PMID:18766339 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased expression of BDNF protein] CTD PMID:24718106 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962 PMID:18815881 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of BRCA2 mRNA] CTD PMID:22712078 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Lovastatin results in increased expression of C1QBP mRNA CTD PMID:20493250 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G Calr calreticulin increases expression ISO Lovastatin results in increased expression of CALR mRNA CTD PMID:20493250 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of CAMK2B protein] CTD PMID:24718106 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Casp2 caspase 2 increases activity
multiple interactions
ISO Lovastatin results in increased activity of CASP2 protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
CTD PMID:12933658 PMID:16234849 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
decreases expression
ISO
EXP
farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
Lovastatin analog results in increased cleavage of CASP3 protein
Lovastatin results in increased activity of CASP3 protein
Lovastatin results in decreased expression of CASP3 mRNA
Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
CTD PMID:11720884 PMID:12933658 PMID:15180944 PMID:16367743 PMID:18034278 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 increases activity ISO Lovastatin results in increased activity of CASP6 protein CTD PMID:11720884 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 increases activity ISO Lovastatin results in increased activity of CASP8 protein CTD PMID:15180944 PMID:15705602 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Lovastatin results in increased activity of CASP9 protein CTD PMID:12933658 PMID:15180944 PMID:15705602 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Lovastatin inhibits the reaction [Epirubicin results in increased expression of CCN2 mRNA] CTD PMID:22712078 PMID:28710503 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression
ISO
EXP
Lovastatin results in decreased expression of CCND1 protein
Lovastatin results in increased expression of CCND1 mRNA; Lovastatin results in increased expression of CCND1 protein
CTD PMID:18034278 PMID:20578043 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Lovastatin results in decreased expression of CCND3 protein CTD PMID:10502407 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 increases expression ISO Lovastatin results in increased expression of CCT5 mRNA CTD PMID:20493250 NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Lovastatin results in increased expression of CCT6A mRNA CTD PMID:20493250 NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337
JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Lovastatin results in decreased expression of CCT8 mRNA CTD PMID:20493250 NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO Lovastatin results in decreased expression of CD44 mRNA; Lovastatin results in decreased expression of CD44 protein CTD PMID:21199873 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdc42 cell division cycle 42 increases expression
decreases expression
ISO Lovastatin results in increased expression of CDC42 protein
Lovastatin results in decreased expression of CDC42 mRNA
CTD PMID:18766339 PMID:20493250 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Lovastatin results in decreased activity of CDK2 protein CTD PMID:10502407 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP Lovastatin results in decreased expression of CDK4 mRNA; Lovastatin results in decreased expression of CDK4 protein CTD PMID:20578043 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases cleavage EXP Lovastatin results in decreased cleavage of CDK5 protein CTD PMID:19741129 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Lovastatin results in increased expression of CDKN1A protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]
CTD PMID:18034278 PMID:22712078 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP
ISO
Lovastatin results in increased expression of CDKN1B mRNA; Lovastatin results in increased expression of CDKN1B protein CTD PMID:9848777 PMID:10502407 PMID:15118409 PMID:18034278 PMID:20578043 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of CDKN3 protein modified form] CTD PMID:26739623 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cenpf centromere protein F increases expression
multiple interactions
ISO Lovastatin results in increased expression of CENPF protein
Lovastatin promotes the reaction [Paclitaxel results in increased expression of CENPF protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein]
CTD PMID:12467231 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
JBrowse link
G Cfl1 cofilin 1 decreases phosphorylation EXP Lovastatin results in decreased phosphorylation of CFL1 protein CTD PMID:20578043 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO
EXP
Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of CHEK1 protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK1 protein modified form]
CTD PMID:17088865 PMID:21356574 PMID:26739623 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of CHEK2 protein modified form] CTD PMID:26739623 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions
increases expression
ISO
EXP
[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased expression of CHRNA7 protein]
Lovastatin results in increased expression of CHRNA7 mRNA; Lovastatin results in increased expression of CHRNA7 protein
U 0126 inhibits the reaction [Lovastatin results in increased expression of CHRNA7 protein]
CTD PMID:29341888 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Lovastatin results in decreased expression of CLIC1 mRNA CTD PMID:20493250 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression ISO Lovastatin results in increased expression of COX5A mRNA CTD PMID:20493250 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of CREB1 protein] CTD PMID:24718106 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases expression ISO Lovastatin results in increased expression of CRK mRNA CTD PMID:20493250 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Ctnnb1 catenin beta 1 decreases degradation
increases expression
multiple interactions
EXP
ISO
Lovastatin results in decreased degradation of CTNNB1 protein
Lovastatin results in increased expression of CTNNB1 mRNA
Lovastatin affects the localization of and results in increased expression of CTNNB1 protein
CTD PMID:17234346 PMID:19741129 PMID:24742230 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of CYP1A1 mRNA]; Lovastatin results in increased expression of and results in increased activity of CYP1A1 protein
Lovastatin results in increased expression of CYP1A1 mRNA
CTD PMID:1311272 PMID:22712078 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Lovastatin results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Lovastatin results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Lovastatin results in increased expression of CYP3A4 mRNA
CTD PMID:12505310 PMID:17041008 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dctn2 dynactin subunit 2 decreases expression ISO Lovastatin results in decreased expression of DCTN2 mRNA CTD PMID:20493250 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543
JBrowse link
G Ddt D-dopachrome tautomerase decreases expression ISO Lovastatin results in decreased expression of DDT mRNA CTD PMID:20493250 NCBI chr20:12,884,216...12,886,687
Ensembl chr20:12,884,243...12,888,482
JBrowse link
G Dlg3 discs large MAGUK scaffold protein 3 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of DLG3 protein] CTD PMID:24718106 NCBI chr  X:65,859,653...65,911,887
Ensembl chr  X:65,860,172...65,910,322
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase decreases expression ISO Lovastatin results in decreased expression of DLST mRNA CTD PMID:20493250 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Dock7 dedicator of cytokinesis 7 increases expression ISO Lovastatin results in increased expression of DOCK7 mRNA CTD PMID:20493250 NCBI chr 5:113,599,371...113,782,871
Ensembl chr 5:113,600,198...113,782,813
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression ISO Lovastatin results in increased expression of DPYSL2 mRNA CTD PMID:20493250 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Dstn destrin, actin depolymerizing factor decreases expression ISO Lovastatin results in decreased expression of DSTN mRNA CTD PMID:20493250 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379
JBrowse link
G Eaf2 ELL associated factor 2 decreases response to substance ISO EAF2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression ISO Lovastatin results in decreased expression of EEF2 mRNA CTD PMID:20493250 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein] CTD PMID:12942316 PMID:19760159 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:12942316 PMID:19760159 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif3i eukaryotic translation initiation factor 3, subunit I decreases expression ISO Lovastatin results in decreased expression of EIF3I mRNA CTD PMID:20493250 NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression
multiple interactions
EXP Lovastatin results in increased expression of ERCC1 mRNA
Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC1 mRNA]
CTD PMID:26739623 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease multiple interactions
increases expression
EXP Lovastatin promotes the reaction [Cisplatin results in increased expression of ERCC5 mRNA]
Lovastatin results in increased expression of ERCC5 mRNA
CTD PMID:26739623 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases expression EXP Lovastatin results in increased expression of ERCC6 mRNA CTD PMID:26739623 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G Erp29 endoplasmic reticulum protein 29 decreases expression ISO Lovastatin results in decreased expression of ERP29 mRNA CTD PMID:20493250 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Fads2 fatty acid desaturase 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FADS2 mRNA CTD PMID:29852127 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA] CTD PMID:17088865 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA] CTD PMID:17088865 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases expression ISO Lovastatin results in increased expression of FASN mRNA CTD PMID:11728391 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
increases expression
ISO geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]; Lovastatin promotes the reaction [Fenofibrate results in increased expression of FBXO32 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein]
Lovastatin results in increased expression of FBXO32 mRNA; Lovastatin results in increased expression of FBXO32 protein
CTD PMID:19406843 PMID:33408297 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases activity ISO Lovastatin results in increased activity of FDFT1 protein CTD PMID:8517861 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FDPS mRNA CTD PMID:29852127 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Flot1 flotillin 1 decreases expression ISO Lovastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression
EXP
ISO
Lovastatin affects the expression of FOS protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of FOS mRNA]
Lovastatin results in decreased expression of FOS
CTD PMID:10412747 PMID:12392621 PMID:22712078 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased expression of FOSB protein] CTD PMID:18434508 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases phosphorylation
ISO Lovastatin promotes the reaction [Fenofibrate results in increased expression of FOXO1 protein]
Lovastatin results in decreased phosphorylation of FOXO1 protein
CTD PMID:33034787 PMID:33408297 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Fscn1 fascin actin-bundling protein 1 decreases expression ISO Lovastatin results in decreased expression of FSCN1 mRNA CTD PMID:20493250 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211
JBrowse link
G G3bp1 G3BP stress granule assembly factor 1 increases expression ISO Lovastatin results in increased expression of G3BP1 mRNA CTD PMID:20493250 NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of G6PD mRNA CTD PMID:29852127 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gale UDP-galactose-4-epimerase decreases expression ISO Lovastatin results in decreased expression of GALE mRNA CTD PMID:20493250 NCBI chr 5:148,193,886...148,198,392
Ensembl chr 5:148,194,791...148,198,388
JBrowse link
G Gap43 growth associated protein 43 increases expression ISO Lovastatin results in increased expression of GAP43 protein CTD PMID:20694854 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 increases expression ISO Lovastatin results in increased expression of GDI2 mRNA CTD PMID:20493250 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366
JBrowse link
G Gk glycerol kinase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of GK mRNA CTD PMID:29852127 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Gmps guanine monophosphate synthase increases expression ISO Lovastatin results in increased expression of GMPS mRNA CTD PMID:20493250 NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; Lovastatin inhibits the reaction [Dietary Fats results in increased expression of GPT protein] CTD PMID:29852127 PMID:30853469 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of GPX1 mRNA] CTD PMID:28710503 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of GRIN2B protein] CTD PMID:24718106 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
increases phosphorylation
ISO
EXP
Lovastatin results in decreased phosphorylation of GSK3B protein
Lovastatin results in increased phosphorylation of GSK3B protein
CTD PMID:17234346 PMID:19741129 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO
EXP
Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]
Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]
CTD PMID:21356574 PMID:22712078 PMID:26739623 PMID:28710503 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Lovastatin results in increased expression of HDAC1 mRNA CTD PMID:20493250 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Lovastatin results in increased expression of HINT1 mRNA CTD PMID:20493250 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
affects expression
decreases activity
increases expression
ISO [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate; [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate]
[Dietary Fats co-treated with Lovastatin] affects the expression of HMGCR mRNA
Lovastatin affects the expression of HMGCR mRNA
Lovastatin results in increased expression of HMGCR mRNA
CTD PMID:8517861 PMID:8593127 PMID:17208200 PMID:19260826 PMID:19699819 More... NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of HMGCS1 mRNA CTD PMID:29852127 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Lovastatin results in increased expression of HMOX1 protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
CTD PMID:20594940 PMID:21910007 PMID:28710503 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression ISO Lovastatin results in increased expression of HNRNPAB mRNA CTD PMID:20493250 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Lovastatin results in decreased expression of HNRNPDL mRNA CTD PMID:20493250 NCBI chr14:9,558,079...9,563,654
Ensembl chr14:9,557,425...9,562,506
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F increases expression ISO Lovastatin results in increased expression of HNRNPF mRNA CTD PMID:20493250 NCBI chr 4:151,083,262...151,104,464
Ensembl chr 4:151,083,062...151,109,038
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression
ISO Lovastatin results in decreased expression of HNRNPK mRNA
Lovastatin results in increased expression of HNRNPK mRNA
CTD PMID:20493250 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases prenylation
multiple interactions
ISO Lovastatin results in decreased prenylation of HRAS protein
Lovastatin results in decreased prenylation of and results in decreased localization of HRAS protein
CTD PMID:16156861 PMID:19360310 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression ISO Lovastatin results in decreased expression of HSP90AB1 mRNA CTD PMID:20493250 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO Lovastatin results in increased expression of HSPA8 mRNA CTD PMID:20493250 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Lovastatin results in increased expression of HSPD1 mRNA CTD PMID:20493250 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Ifng interferon gamma multiple interactions ISO Lovastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance ISO IGF1 protein results in decreased susceptibility to Lovastatin CTD PMID:9525472 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein] CTD PMID:19741129 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein] CTD PMID:18809656 PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA] CTD PMID:28710503 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]; Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig1 insulin induced gene 1 increases expression
multiple interactions
ISO Lovastatin results in increased expression of INSIG1 mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of INSIG1 mRNA
CTD PMID:19260826 PMID:29852127 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of INSIG2 mRNA CTD PMID:29852127 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Insr insulin receptor multiple interactions EXP Lovastatin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:19741129 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Ipo5 importin 5 decreases expression ISO Lovastatin results in decreased expression of IPO5 mRNA CTD PMID:20493250 NCBI chr15:97,990,755...98,041,074
Ensembl chr15:98,005,299...98,041,126
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO Lovastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of IRS1 mRNA CTD PMID:29852127 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of IRS2 mRNA CTD PMID:29852127 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 increases expression ISO Lovastatin results in increased expression of ISYNA1 mRNA CTD PMID:20493250 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Lovastatin results in decreased expression of ITGB1 protein CTD PMID:12405293 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression
multiple interactions
decreases expression
EXP
ISO
Lovastatin affects the expression of JUN protein
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of JUN mRNA]
Lovastatin results in decreased expression of JUN
CTD PMID:10412747 PMID:12392621 PMID:22712078 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects activity ISO Lovastatin affects the activity of KCNH2 protein CTD PMID:16278312 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases prenylation
increases expression
affects localization
increases activity
ISO Lovastatin results in decreased prenylation of KRAS protein
Lovastatin results in increased expression of KRAS protein
Lovastatin affects the localization of KRAS protein
Lovastatin results in increased activity of KRAS protein
CTD PMID:12106604 PMID:12907238 PMID:16156861 PMID:17005160 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt18 keratin 18 decreases expression ISO Lovastatin results in decreased expression of KRT18 mRNA CTD PMID:20493250 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Lasp1 LIM and SH3 protein 1 decreases expression ISO Lovastatin results in decreased expression of LASP1 mRNA CTD PMID:20493250 NCBI chr10:82,795,177...82,835,659
Ensembl chr10:82,795,137...82,943,292
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA CTD PMID:30853469 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases activity
increases expression
ISO
EXP
OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of LDLR mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]
Lovastatin results in increased activity of LDLR protein
CTD PMID:8593127 PMID:11728391 PMID:12524230 PMID:20578043 PMID:29852127 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 affects localization ISO Lovastatin affects the localization of LEF1 protein CTD PMID:17234346 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Lipc lipase C, hepatic type affects expression ISO Lovastatin affects the expression of LIPC mRNA CTD PMID:27208389 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lmnb1 lamin B1 decreases farnesylation
increases degradation
affects localization
ISO Lovastatin results in decreased farnesylation of LMNB1 protein
Lovastatin results in increased degradation of LMNB1 protein
Lovastatin affects the localization of LMNB1 protein
CTD PMID:10203554 PMID:11720884 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Lpin2 lipin 2 decreases response to substance ISO LPIN2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193
JBrowse link
G Lpl lipoprotein lipase affects expression
multiple interactions
ISO Lovastatin affects the expression of LPL mRNA
[Dietary Fats co-treated with Lovastatin] affects the expression of LPL mRNA
CTD PMID:27208389 PMID:29852127 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp5 LDL receptor related protein 5 increases expression ISO Lovastatin results in increased expression of LRP5 mRNA CTD PMID:24742230 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK1 protein]; Lovastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK1 protein]
Lovastatin results in decreased activity of MAPK1 protein
[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK1 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK1 protein]
CTD PMID:12213976 PMID:16952276 PMID:19360310 PMID:19760159 PMID:20578043 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases activity
decreases phosphorylation
ISO
EXP
[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of APP protein]; Lovastatin affects the reaction [[MAPK3 protein co-treated with APP protein] affects the expression of CHRNA7 protein]; Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [[Lovastatin co-treated with APP protein] results in increased phosphorylation of MAPK3 protein]
Lovastatin results in increased phosphorylation of MAPK3 protein
Lovastatin results in decreased activity of MAPK3 protein
Lovastatin results in decreased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in decreased phosphorylation of MAPK3 protein]; Lovastatin inhibits the reaction [benserazide, levodopa drug combination results in increased phosphorylation of MAPK3 protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Lovastatin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16952276 PMID:18434508 PMID:19360310 PMID:19760159 PMID:20578043 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK8 protein modified form] CTD PMID:26739623 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Lovastatin inhibits the reaction [Cisplatin results in increased expression of MAPK9 protein modified form] CTD PMID:26739623 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mbp myelin basic protein multiple interactions
increases expression
EXP 2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA] CTD PMID:20578043 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MFN2 mRNA] CTD PMID:28710503 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA CTD PMID:30853469 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA CTD PMID:30853469 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Lovastatin results in decreased expression of MMP2 protein CTD PMID:19360310 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA] CTD PMID:28710503 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Lovastatin results in decreased expression of MMP9 protein CTD PMID:19360310 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mstn myostatin increases expression ISO Lovastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,453,982...48,458,809
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Doxorubicin inhibits the reaction [Lovastatin results in increased expression of NFE2L2 mRNA]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NFE2L2 mRNA] CTD PMID:22712078 PMID:28710503 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nmral1 NmrA like redox sensor 1 increases expression ISO Lovastatin results in increased expression of NMRAL1 mRNA CTD PMID:20493250 NCBI chr10:10,841,693...10,850,199
Ensembl chr10:10,841,799...10,850,192
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:18809656 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of NPPA mRNA] CTD PMID:28710503 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Lovastatin results in increased expression of NQO1 mRNA CTD PMID:1311272 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases prenylation ISO Lovastatin results in decreased prenylation of NRAS protein CTD PMID:16156861 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Nucb1 nucleobindin 1 increases expression ISO Lovastatin results in increased expression of NUCB1 mRNA CTD PMID:20493250 NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220
JBrowse link
G Oat ornithine aminotransferase decreases expression ISO Lovastatin results in decreased expression of OAT mRNA CTD PMID:20493250 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Osm oncostatin M multiple interactions ISO OSM protein promotes the reaction [Lovastatin results in increased expression of LDLR mRNA] CTD PMID:12524230 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression ISO Lovastatin results in increased expression of PA2G4 mRNA CTD PMID:20493250 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Lovastatin analog results in increased cleavage of PARP1 protein CTD PMID:26863638 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parvb parvin, beta decreases response to substance ISO PARVB SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 7:115,360,254...115,445,767
Ensembl chr 7:115,360,261...115,445,766
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of PCK1 mRNA CTD PMID:29852127 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases expression EXP Lovastatin results in decreased expression of PDGFRA mRNA CTD PMID:20578043 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression
increases expression
ISO Lovastatin results in decreased expression of PDIA3 mRNA
Lovastatin results in increased expression of PDIA3 mRNA
CTD PMID:20493250 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression ISO Lovastatin results in decreased expression of PDIA4 mRNA CTD PMID:20493250 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression
increases expression
ISO Lovastatin results in decreased expression of PGAM1 mRNA
Lovastatin results in increased expression of PGAM1 mRNA
CTD PMID:20493250 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Lovastatin results in decreased expression of PKM mRNA CTD PMID:20493250 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression EXP Lovastatin results in increased expression of PLA2G4A mRNA CTD PMID:20578043 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions
increases secretion
increases expression
EXP
ISO
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]
Lovastatin results in increased secretion of PLAT protein
CTD PMID:10412747 PMID:12405293 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase decreases secretion ISO Lovastatin results in decreased secretion of PLAU protein CTD PMID:12405293 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis
increases metabolic processing
multiple interactions
ISO PON3 protein results in increased hydrolysis of Lovastatin
PON3 protein results in increased metabolism of Lovastatin
7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]; Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin]
CTD PMID:12615656 PMID:15772423 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
affects localization
increases expression
ISO
EXP
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Lovastatin analog affects the localization of PPARG protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; Lovastatin results in increased expression of and affects the localization of PPARG protein; Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
[Dietary Fats co-treated with Lovastatin] affects the expression of PPARG mRNA; PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]
CTD PMID:16425225 PMID:20578043 PMID:26863638 PMID:29852127 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of PPARGC1A mRNA] CTD PMID:28710503 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO Lovastatin results in decreased expression of PPP1CA mRNA CTD PMID:20493250 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha increases expression ISO Lovastatin results in increased expression of PPP2R1A mRNA CTD PMID:20493250 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases cleavage
EXP benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein]; Mevalonic Acid inhibits the reaction [Lovastatin results in increased cleavage of PRKCD protein] CTD PMID:16367743 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Psma3 proteasome 20S subunit alpha 3 decreases expression ISO Lovastatin results in decreased expression of PSMA3 mRNA CTD PMID:20493250 NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 decreases expression ISO Lovastatin results in decreased expression of PSMA6 mRNA CTD PMID:20493250 NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554
JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO Lovastatin results in decreased expression of PSMC2 mRNA CTD PMID:20493250 NCBI chr 4:13,255,851...13,270,102
Ensembl chr 4:13,255,856...13,270,185
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression
ISO
EXP
Cycloheximide inhibits the reaction [Lovastatin results in increased expression of PTEN protein]; PPARG protein affects the reaction [Lovastatin results in increased expression of PTEN protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA]; Lovastatin results in increased expression of and results in increased phosphorylation of PTEN protein; PTEN protein affects the reaction [Lovastatin results in increased expression of MBP mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]
PPARG affects the reaction [Lovastatin results in increased expression of PTEN protein]
CTD PMID:16425225 PMID:20578043 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
increases expression
multiple interactions
ISO
EXP
Lovastatin results in decreased expression of PTGS2 protein
Lovastatin analog results in increased expression of PTGS2 mRNA; Lovastatin analog results in increased expression of PTGS2 protein
Mevalonic Acid affects the reaction [Lovastatin analog results in increased expression of PTGS2 protein]
Lovastatin results in increased expression of PTGS2 mRNA; Lovastatin results in increased expression of PTGS2 protein
CTD PMID:20578043 PMID:21910007 PMID:26863638 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rab1a RAB1A, member RAS oncogene family decreases expression ISO Lovastatin results in decreased expression of RAB1A mRNA CTD PMID:20493250 NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
affects localization
decreases activity
increases expression
ISO geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]
Lovastatin results in decreased activity of RAC1 protein
Lovastatin results in increased expression of RAC1 protein
CTD PMID:12933658 PMID:18766339 PMID:19360310 PMID:21356574 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions
decreases activity
ISO Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of RAF1 protein]
Lovastatin results in decreased activity of RAF1 protein
CTD PMID:19360310 PMID:19760159 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family increases expression ISO Lovastatin results in increased expression of RAP1A protein CTD PMID:12467231 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP
ISO
Lovastatin results in decreased phosphorylation of RB1 protein CTD PMID:9848777 PMID:10502407 PMID:15118409 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rhoa ras homolog family member A multiple interactions
decreases expression
decreases prenylation
affects localization
ISO
EXP
geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Lovastatin results in decreased geranoylation of and affects the localization of RHOA protein
Lovastatin results in decreased expression of RHOA mRNA
Lovastatin results in decreased prenylation of RHOA protein
Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]; geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RHOA protein]
CTD PMID:9398081 PMID:11178870 PMID:12405293 PMID:12933658 PMID:16156861 More... NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B decreases prenylation
multiple interactions
increases expression
ISO Lovastatin results in decreased prenylation of RHOB protein
Lovastatin promotes the reaction [RHOB protein binds to CASP2 protein]
Lovastatin results in increased expression of RHOB protein
CTD PMID:12467231 PMID:16156861 PMID:16234849 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rpl27 ribosomal protein L27 increases expression ISO Lovastatin results in increased expression of RPL27 mRNA CTD PMID:20493250 NCBI chr10:86,375,511...86,379,210
Ensembl chr10:86,375,454...86,379,193
JBrowse link
G Rpl9 ribosomal protein L9 increases expression ISO Lovastatin results in increased expression of RPL9 mRNA CTD PMID:20493250 NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Lovastatin results in increased expression of RPLP0 mRNA CTD PMID:20493250 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Lovastatin results in increased expression of RPSA mRNA CTD PMID:20493250 NCBI chr 8:119,851,225...119,855,103
Ensembl chr 8:119,851,225...119,855,247
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 decreases expression ISO Lovastatin results in decreased expression of RUVBL2 mRNA CTD PMID:20493250 NCBI chr 1:95,902,014...95,915,364
Ensembl chr 1:95,901,701...95,915,342
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA CTD PMID:30853469 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA CTD PMID:30853469 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression ISO Lovastatin results in decreased expression of SAE1 mRNA CTD PMID:20493250 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Scap SREBF chaperone multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SCAP mRNA CTD PMID:29852127 NCBI chr 8:110,306,031...110,360,677
Ensembl chr 8:110,306,031...110,360,666
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
affects expression
ISO [Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
Lovastatin affects the expression of SCARB1 mRNA
CTD PMID:20404351 PMID:27208389 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SCD1 mRNA CTD PMID:29852127 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sephs1 selenophosphate synthetase 1 increases expression ISO Lovastatin results in increased expression of SEPHS1 mRNA CTD PMID:20493250 NCBI chr17:73,354,435...73,382,803
Ensembl chr17:73,356,530...73,382,593
JBrowse link
G Slc31a1 solute carrier family 31 member 1 increases expression EXP Lovastatin results in increased expression of SLC31A1 mRNA CTD PMID:26739623 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Sox10 SRY-box transcription factor 10 multiple interactions
increases expression
EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PPARG protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA]; PTEN protein affects the reaction [Lovastatin results in increased expression of SOX10 mRNA] CTD PMID:20578043 NCBI chr 7:110,725,274...110,735,544
Ensembl chr 7:110,725,274...110,735,544
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
ISO [Dietary Fats co-treated with Lovastatin] affects the expression of SREBF1 mRNA
Lovastatin results in increased expression of SREBF1 mRNA
CTD PMID:29852127 PMID:32739440 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases localization
multiple interactions
ISO
EXP
Lovastatin results in increased localization of SREBF2 protein
[Dietary Fats co-treated with Lovastatin] affects the expression of SREBF2 mRNA
[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]
CTD PMID:11728391 PMID:20578043 PMID:29852127 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Steap2 STEAP2 metalloreductase decreases response to substance ISO STEAP2 SNP results in decreased susceptibility to Lovastatin CTD PMID:21483694 NCBI chr 4:28,347,769...28,368,177
Ensembl chr 4:28,348,362...28,375,791
JBrowse link
G Stip1 stress-induced phosphoprotein 1 decreases expression ISO Lovastatin results in decreased expression of STIP1 mRNA CTD PMID:20493250 NCBI chr 1:204,209,434...204,228,452
Ensembl chr 1:204,178,932...204,228,476
JBrowse link
G Syngap1 synaptic Ras GTPase activating protein 1 multiple interactions EXP Lovastatin inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of SYNGAP1 protein] CTD PMID:24718106 NCBI chr20:5,026,366...5,056,659
Ensembl chr20:5,026,364...5,056,672
JBrowse link
G Tcp1 t-complex 1 increases expression ISO Lovastatin results in increased expression of TCP1 mRNA CTD PMID:20493250 NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839
JBrowse link
G Tg thyroglobulin increases secretion ISO Lovastatin results in increased secretion of TG protein CTD PMID:12843138 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Lovastatin inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; Lovastatin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:22129737 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
ISO Lovastatin results in increased expression of TH protein
Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein]
CTD PMID:20694854 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thop1 thimet oligopeptidase 1 increases expression ISO Lovastatin results in increased expression of THOP1 mRNA CTD PMID:20493250 NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Lovastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein] CTD PMID:18809656 PMID:21430599 PMID:22712078 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO Lovastatin results in increased expression of TNFRSF11B mRNA CTD PMID:24742230 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Lovastatin results in increased susceptibility to TNFSF10 protein CTD PMID:17928957 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Lovastatin results in decreased expression of TNFSF11 mRNA CTD PMID:24742230 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TOP2A mRNA] CTD PMID:22712078 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Lovastatin inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; Lovastatin results in increased expression of and results in increased phosphorylation of TP53 protein
Lovastatin inhibits the reaction [Cisplatin results in increased expression of TP53 protein modified form]
Lovastatin results in increased expression of TP53 mRNA
CTD PMID:17088865 PMID:21199873 PMID:26739623 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO Lovastatin promotes the reaction [Fenofibrate results in increased expression of TRIM63 protein] CTD PMID:33408297 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Ttc7a tetratricopeptide repeat domain 7A multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of FSN mRNA CTD PMID:29852127 NCBI chr 6:7,159,285...7,261,826
Ensembl chr 6:7,159,061...7,261,892
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression ISO Lovastatin results in increased expression of TUBA1A mRNA CTD PMID:20493250 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
JBrowse link
G Tuba1b tubulin, alpha 1B increases expression
decreases expression
ISO Lovastatin results in increased expression of TUBA1B mRNA
Lovastatin results in decreased expression of TUBA1B mRNA
CTD PMID:20493250 NCBI chr 7:130,090,669...130,093,644
Ensembl chr 7:130,081,032...130,196,186
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Lovastatin results in decreased expression of TUBB5 mRNA CTD PMID:20493250 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases expression ISO Lovastatin results in decreased expression of TUFM mRNA CTD PMID:20493250 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression ISO Lovastatin results in increased expression of U2AF2 mRNA CTD PMID:20493250 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Dietary Fats co-treated with Lovastatin] affects the expression of UCP2 mRNA CTD PMID:29852127 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Usp5 ubiquitin specific peptidase 5 decreases expression ISO Lovastatin results in decreased expression of USP5 mRNA CTD PMID:20493250 NCBI chr 4:157,619,643...157,634,711
Ensembl chr 4:157,619,643...157,634,711
JBrowse link
G Vcp valosin-containing protein decreases expression
increases expression
ISO Lovastatin results in decreased expression of VCP mRNA
Lovastatin results in increased expression of VCP mRNA
CTD PMID:20493250 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions
increases expression
ISO Lovastatin inhibits the reaction [Doxorubicin results in increased expression of WEE1 mRNA]
Lovastatin results in increased expression of WEE1 mRNA
CTD PMID:22712078 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression EXP Lovastatin results in increased expression of XIAP mRNA CTD PMID:26739623 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression EXP Lovastatin results in increased expression of XPA mRNA CTD PMID:26739623 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression ISO Lovastatin results in increased expression of YWHAE mRNA CTD PMID:20493250 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
mevastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 affects expression
decreases expression
multiple interactions
EXP
ISO
mevastatin affects the expression of ABCA1 mRNA
Mevastatin (compactin) decreases expression of abca1 mRNA in rat peripheral fibroblasts
Mevalonic Acid inhibits the reaction [mevastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]]
CTD
RGD
PMID:16415093 PMID:17526932 PMID:17526932 RGD:2308820 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO mevastatin inhibits the reaction [BDNF protein results in decreased activity of HU 211] CTD PMID:20554863 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO mevastatin results in increased expression of BMP2 mRNA; mevastatin results in increased expression of BMP2 protein CTD PMID:10814523 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 PMID:15466163 PMID:17041008 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA] CTD PMID:16330322 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO mevastatin results in increased phosphorylation of EIF2AK3 protein CTD PMID:16330322 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in decreased expression of DDIT3 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA]; EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA] CTD PMID:16330322 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO mevastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 multiple interactions
increases expression
ISO EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of IDI1 mRNA] CTD PMID:16330322 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifng interferon gamma multiple interactions ISO mevastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA] CTD PMID:17507688 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO mevastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression
multiple interactions
ISO mevastatin results in increased expression of MSMO1 mRNA
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased expression of MSMO1 mRNA]
CTD PMID:16330322 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mstn myostatin increases expression ISO mevastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,453,982...48,458,809
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 PMID:17041008 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO mevastatin results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein] CTD PMID:16734383 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rhoa ras homolog family member A decreases lipidation
multiple interactions
ISO mevastatin results in decreased lipidation of RHOA protein
Mevalonic Acid inhibits the reaction [mevastatin results in decreased lipidation of RHOA protein]
CTD PMID:17322126 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Sele selectin E multiple interactions ISO mevastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]; mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases cleavage
multiple interactions
EXP
ISO
mevastatin results in decreased expression of SREBF1 protein
mevastatin results in increased cleavage of SREBF1 protein
EIF2S1 protein modified form inhibits the reaction [mevastatin results in increased cleavage of SREBF1 protein]
CTD PMID:16330322 PMID:17526932 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
increases cleavage
EXP
ISO
mevastatin results in increased expression of SREBF2 protein
mevastatin results in increased cleavage of SREBF2 protein
CTD PMID:16330322 PMID:17526932 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mevastatin promotes the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:10946302 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO Tunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein] CTD PMID:16330322 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
pitavastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO
EXP
GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
pitavastatin increases expression of ABCA1 mRNA in HepG2 cells
pitavastatin increases expression of abca1 mRNA in rat liver
pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]
CTD
RGD
PMID:16415093 PMID:21554872 PMID:21554872 PMID:21554872 RGD:21408554, RGD:21408554 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; pitavastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
pitavastatin results in decreased activity of ABCB11 protein
CTD PMID:15901796 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport
multiple interactions
ISO
EXP
ABCC2 protein affects the transport of pitavastatin
ABCC2 protein binds to and results in increased uptake of pitavastatin analog; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
CTD PMID:15955871 PMID:23562342 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects transport ISO ABCG2 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:18323514 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO pitavastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:18323514 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il6 interleukin 6 multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA] CTD PMID:18323514 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein] CTD PMID:18323514 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression ISO pitavastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
JBrowse link
G Lep leptin multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mstn myostatin increases expression ISO pitavastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,453,982...48,458,809
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA] CTD PMID:18323514 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO NR1H2 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H2 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO NR1H3 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H3 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Pon1 paraoxonase 1 increases expression
multiple interactions
ISO pitavastatin results in increased expression of PON1 mRNA
farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]
CTD PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
ISO pitavastatin results in increased expression of PPARA mRNA
pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
CTD PMID:11779144 PMID:21554872 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO pitavastatin results in increased expression of PPARD mRNA CTD PMID:21554872 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport ISO SLCO1A4 protein affects the transport of pitavastatin CTD PMID:19833843 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:18323514 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
pravastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
decreases expression
EXP
ISO
[[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterol; [colestimide co-treated with Pravastatin] affects the expression of ABCA1 mRNA; [colestimide co-treated with Pravastatin] affects the expression of ABCA1 protein
cotreatment with pravastatin and colestimide increases expression of abca1 mRNA and protein in rat liver; and decreases expression of abca1 mRNA and protein in rat small intestine
Pravastatin results in decreased expression of ABCA1
CTD
RGD
PMID:17526932 PMID:19461118 PMID:17526932 RGD:2308820 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
affects import
ISO Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
ABCB11 protein affects the import of Pravastatin
CTD PMID:15901796 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Pravastatin; ABCB1 protein results in increased transport of Pravastatin analog CTD PMID:15616150 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Pravastatin results in increased expression of ABCB4 mRNA CTD PMID:15242490 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases expression
multiple interactions
affects transport
ISO
EXP
ABCC2 protein affects the export of Pravastatin
Pravastatin results in increased expression of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Pravastatin analog; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the transport of Pravastatin
CTD PMID:15901800 PMID:15955871 PMID:23562342 PMID:24909372 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Pravastatin results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Pravastatin CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO Pravastatin results in decreased expression of ABCD3 mRNA CTD PMID:27225895 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
increases activity
ISO ABCG2 protein affects the export of Pravastatin
Pravastatin results in increased activity of ABCG2 protein
CTD PMID:15901800 PMID:27475308 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Pravastatin results in increased expression of ABCG5 mRNA CTD PMID:15242490 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Pravastatin results in increased expression of ABCG8 mRNA CTD PMID:15242490 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression ISO Pravastatin results in decreased expression of ACAA1B mRNA CTD PMID:27225895 NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of ACAA2 mRNA CTD PMID:27225895 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACAT1 mRNA CTD PMID:27225895 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions EXP [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in increased expression of ACE protein] CTD PMID:29682576 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein] CTD PMID:29682576 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ACOT1 mRNA
Pravastatin results in decreased expression of ACOT1 mRNA
CTD PMID:27225895 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acot12 acyl-CoA thioesterase 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACOT12 mRNA CTD PMID:27225895 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536
JBrowse link
G Acot2 acyl-CoA thioesterase 2 affects expression ISO Pravastatin affects the expression of ACOT2 mRNA CTD PMID:27225895 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot3 acyl-CoA thioesterase 3 decreases expression ISO Pravastatin results in decreased expression of ACOT3 mRNA CTD PMID:27225895 NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427
JBrowse link
G Acot4 acyl-CoA thioesterase 4 decreases expression ISO Pravastatin results in decreased expression of ACOT4 mRNA CTD PMID:27225895 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACOX1 mRNA CTD PMID:27225895 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ACSF2 mRNA
Pravastatin results in decreased expression of ACSF2 mRNA
CTD PMID:27225895 NCBI chr10:79,504,510...79,546,714
Ensembl chr10:79,504,511...79,546,673
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Pravastatin results in decreased expression of ACSL1 mRNA CTD PMID:27225895 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP
ISO
Pravastatin results in decreased expression of ACTA1 mRNA CTD PMID:27225895 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression ISO
EXP
Pravastatin results in increased expression of ADAMDEC1 mRNA CTD PMID:27225895 NCBI chr15:42,900,629...42,923,136
Ensembl chr15:42,900,636...42,921,712
JBrowse link
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression ISO
EXP
Pravastatin results in decreased expression of ADH1 mRNA CTD PMID:27225895 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression EXP
ISO
Pravastatin results in decreased expression of ADH7 mRNA CTD PMID:27225895 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Agt angiotensinogen decreases expression EXP
ISO
Pravastatin results in decreased expression of AGT mRNA CTD PMID:27225895 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of AIF1 mRNA CTD PMID:27225895 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression ISO
EXP
Pravastatin results in decreased expression of AKR1C18 mRNA
Pravastatin results in decreased expression of AKR1C3 mRNA
CTD PMID:27225895 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein]
[Pravastatin co-treated with olmesartan] results in increased phosphorylation of AKT1 protein; [resveratrol co-treated with Pravastatin] results in increased phosphorylation of AKT1 protein
Pravastatin results in increased phosphorylation of AKT1 protein
CTD PMID:17170375 PMID:17188708 PMID:18483861 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO
EXP
Pravastatin results in decreased expression of ALDH1A1 mRNA CTD PMID:16763553 PMID:27225895 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions
decreases expression
ISO Cholesterol, Dietary inhibits the reaction [Pravastatin results in decreased expression of ALDH1A2 mRNA] CTD PMID:16763553 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects expression EXP
ISO
Pravastatin affects the expression of ALDH1A3 mRNA CTD PMID:27225895 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Aldoart2 aldolase 1 A retrogene 2 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of ALDOART2 mRNA
Pravastatin results in decreased expression of ALDOART2 mRNA
CTD PMID:27225895 NCBI chr 6:72,939,821...72,941,511
Ensembl chr 6:72,939,788...72,941,709
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression EXP
ISO
Pravastatin results in increased expression of AMPD3 mRNA CTD PMID:27225895 NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of ANGPTL3 mRNA CTD PMID:27225895 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
JBrowse link
G Ank2 ankyrin 2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ANK2 mRNA
Pravastatin results in decreased expression of ANK2 mRNA
CTD PMID:27225895 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
JBrowse link
G Anks6 ankyrin repeat and sterile alpha motif domain containing 6 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ANKS6 mRNA
Pravastatin results in decreased expression of ANKS6 mRNA
CTD PMID:27225895 NCBI chr 5:61,309,183...61,350,596
Ensembl chr 5:61,309,183...61,350,596
JBrowse link
G Apoa1 apolipoprotein A1 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of APOA1 mRNA
Pravastatin results in decreased expression of APOA1 mRNA
CTD PMID:27225895 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G App amyloid beta precursor protein increases expression ISO Pravastatin results in increased expression of APP CTD PMID:19461118 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arg2 arginase 2 increases expression ISO Pravastatin results in increased expression of ARG2 mRNA CTD PMID:27225895 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of ARHGAP11A mRNA
Pravastatin affects the expression of ARHGAP11A mRNA
CTD PMID:27225895 NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of ARRDC3 mRNA CTD PMID:27225895 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha decreases expression ISO
EXP
Pravastatin results in decreased expression of ATP4A mRNA CTD PMID:27225895 NCBI chr 1:85,961,607...85,974,972
Ensembl chr 1:85,961,708...85,974,844
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ATP6V0D2 mRNA
Pravastatin results in decreased expression of ATP6V0D2 mRNA
CTD PMID:27225895 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Axin2 axin 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of AXIN2 mRNA CTD PMID:27225895 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of BARD1 mRNA
Pravastatin affects the expression of BARD1 mRNA
CTD PMID:27225895 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BAX protein CTD PMID:26875785 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BCL2 protein CTD PMID:26875785 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 decreases expression EXP
ISO
Pravastatin results in decreased expression of BHLHA15 mRNA CTD PMID:27225895 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
JBrowse link
G Bmal2 basic helix-loop-helix ARNT like 2 increases expression
affects expression
ISO
EXP
Pravastatin results in increased expression of ARNTL2 mRNA
Pravastatin affects the expression of BMAL2 mRNA
CTD PMID:27225895 NCBI chr 4:179,699,432...179,747,710
Ensembl chr 4:179,699,502...179,746,949
JBrowse link
G Bmper BMP-binding endothelial regulator affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of BMPER mRNA
Pravastatin results in increased expression of BMPER mRNA
CTD PMID:27225895 NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of BUB1B mRNA
Pravastatin results in decreased expression of BUB1B mRNA
CTD PMID:27225895 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G C16h4orf47 similar to human chromosome 4 open reading frame 47 increases expression EXP Pravastatin results in increased expression of C16H4ORF47 mRNA CTD PMID:27225895 NCBI chr16:46,291,075...46,315,616
Ensembl chr16:46,291,311...46,315,625
JBrowse link
G C1qb complement C1q B chain decreases expression ISO
EXP
Pravastatin results in decreased expression of C1QB mRNA CTD PMID:27225895 NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407
JBrowse link
G C1qc complement C1q C chain decreases expression EXP
ISO
Pravastatin results in decreased expression of C1QC mRNA CTD PMID:27225895 NCBI chr 5:149,127,424...149,130,732
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of C5AR1 mRNA CTD PMID:27225895 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased cleavage of CASP3 protein; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]
Pravastatin results in increased cleavage of CASP3 protein
Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:18483861 PMID:20368269 PMID:26875785 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein] CTD PMID:18483861 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases activity ISO Pravastatin results in increased activity of CAT protein CTD PMID:17479860 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl12 C-C motif chemokine ligand 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of CCL12 mRNA CTD PMID:27225895 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased secretion of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein]
CTD PMID:18323514 PMID:20884875 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 decreases expression ISO
EXP
Pravastatin results in decreased expression of CCL6 mRNA CTD PMID:27225895 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
JBrowse link
G Cd209a CD209a molecule decreases expression ISO Pravastatin results in decreased expression of CD209 mRNA CTD PMID:27225895 NCBI chr12:1,822,663...1,828,246
Ensembl chr12:1,822,663...1,828,246
JBrowse link
G Cd209d CD209d molecule decreases expression EXP Pravastatin results in decreased expression of CD209 mRNA CTD PMID:27225895 NCBI chr12:1,891,109...1,897,559
Ensembl chr12:1,891,113...1,901,171
JBrowse link
G Cd28 Cd28 molecule decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CD28 mRNA
Pravastatin affects the expression of CD28 mRNA
CTD PMID:27225895 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd40 CD40 molecule affects expression EXP
ISO
Pravastatin affects the expression of CD40 mRNA CTD PMID:27225895 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd7 Cd7 molecule decreases expression EXP
ISO
Pravastatin results in decreased expression of CD7 mRNA CTD PMID:27225895 NCBI chr10:106,304,046...106,306,963
Ensembl chr10:106,304,056...106,306,967
JBrowse link
G Cdc27 cell division cycle 27 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of CDC27 mRNA
Pravastatin results in increased expression of CDC27 mRNA
CTD PMID:27225895 NCBI chr10:89,400,931...89,449,823
Ensembl chr10:89,400,940...89,449,736
JBrowse link
G Cdc6 cell division cycle 6 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of CDC6 mRNA
Pravastatin affects the expression of CDC6 mRNA
CTD PMID:27225895 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Cdca7l cell division cycle associated 7 like affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of CDCA7L mRNA
Pravastatin results in decreased expression of CDCA7L mRNA
CTD PMID:27225895 NCBI chr 6:138,793,953...138,839,889
Ensembl chr 6:138,794,228...138,839,888
JBrowse link
G Cdhr5 cadherin-related family member 5 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of CDHR5 mRNA
Pravastatin results in increased expression of CDHR5 mRNA
CTD PMID:27225895 NCBI chr 1:196,373,110...196,381,609
Ensembl chr 1:196,373,112...196,381,543
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Pravastatin inhibits the reaction [Benzo(a)pyrene results in decreased degradation of CDKN1A protein]; Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein] CTD PMID:15625077 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases expression ISO
EXP
Pravastatin results in increased expression of CDS1 mRNA CTD PMID:27225895 NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO Pravastatin results in increased expression of CEBPD mRNA CTD PMID:27225895 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cers6 ceramide synthase 6 decreases expression ISO Pravastatin results in decreased expression of CERS6 mRNA CTD PMID:27225895 NCBI chr 3:53,630,636...53,879,692
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Cesl1 carboxylesterase-like 1 decreases expression EXP Pravastatin results in decreased expression of CESL1 mRNA CTD PMID:27225895 NCBI chr19:22,670,709...23,006,329
Ensembl chr19:22,670,712...22,712,608
JBrowse link
G Cip2a cellular inhibitor of PP2A decreases expression EXP Pravastatin results in decreased expression of CIP2A mRNA CTD PMID:27225895 NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938
JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of CITED1 mRNA
Pravastatin results in increased expression of CITED1 mRNA
CTD PMID:27225895 NCBI chr  X:67,350,376...67,355,072
Ensembl chr  X:67,350,373...67,355,162
JBrowse link
G Clcn6 chloride voltage-gated channel 6 increases expression ISO
EXP
Pravastatin results in increased expression of CLCN6 mRNA CTD PMID:27225895 NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059
JBrowse link
G Clec4f C-type lectin domain family 4, member F decreases expression EXP
ISO
Pravastatin results in decreased expression of CLEC4F mRNA CTD PMID:27225895 NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
JBrowse link
G Clstn3 calsyntenin 3 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CLSTN3 mRNA
Pravastatin affects the expression of CLSTN3 mRNA
CTD PMID:27225895 NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769
JBrowse link
G Cnn1 calponin 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of CNN1 mRNA CTD PMID:27225895 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CPT1B mRNA
Pravastatin affects the expression of CPT1B mRNA
CTD PMID:27225895 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Pravastatin results in decreased expression of CPT2 mRNA CTD PMID:27225895 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Crat carnitine O-acetyltransferase increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of CRAT mRNA
Pravastatin affects the expression of CRAT mRNA
CTD PMID:27225895 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CREB3L3 mRNA
Pravastatin affects the expression of CREB3L3 mRNA
CTD PMID:27225895 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
JBrowse link
G Crp C-reactive protein decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of CRP mRNA
Pravastatin results in increased expression of CRP mRNA
CTD PMID:27225895 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP
ISO
Pravastatin results in decreased expression of CSAD mRNA CTD PMID:27225895 NCBI chr 7:133,308,571...133,337,914
Ensembl chr 7:133,308,574...133,337,615
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases expression EXP
ISO
Pravastatin results in decreased expression of CSF1R mRNA CTD PMID:27225895 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csmd1 CUB and Sushi multiple domains 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of CSMD1 mRNA CTD PMID:27225895 NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614
JBrowse link
G Ctnnb1 catenin beta 1 affects localization
multiple interactions
EXP Pravastatin affects the localization of CTNNB1 protein
[resveratrol co-treated with Pravastatin] affects the localization of CTNNB1 protein
CTD PMID:17188708 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of CXCL2 mRNA
Pravastatin results in increased expression of CXCL2 mRNA
CTD PMID:27225895 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP Pravastatin results in decreased expression of CYBA protein CTD PMID:17170375 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein] CTD PMID:18483861 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of CYP1A2 mRNA CTD PMID:27225895 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of CYP1B1 mRNA
Pravastatin results in increased expression of CYP1B1 mRNA
CTD PMID:27225895 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO Pravastatin affects the expression of CYP2B10 mRNA CTD PMID:27225895 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 decreases expression EXP Pravastatin results in decreased expression of CYP2B21 mRNA CTD PMID:27225895 NCBI chr 1:81,886,097...81,915,066
Ensembl chr 1:81,886,098...81,915,066
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Pravastatin results in decreased expression of CYP2D3 mRNA CTD PMID:27225895 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP Pravastatin results in decreased expression of CYP2J4 mRNA CTD PMID:27225895 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Pravastatin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:27225895 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP Pravastatin results in decreased expression of CYP4A1 mRNA CTD PMID:27225895 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 affects expression EXP Pravastatin affects the expression of CYP4A2 mRNA CTD PMID:27225895 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP Pravastatin results in decreased expression of CYP4A3 mRNA CTD PMID:27225895 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO
Pravastatin results in increased expression of CYP51 mRNA CTD PMID:27225895 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of DECR1 mRNA CTD PMID:27225895 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of DEPDC1B mRNA
Pravastatin affects the expression of DEPDC1B mRNA
CTD PMID:27225895 NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
JBrowse link
G Derl3 derlin 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of DERL3 mRNA CTD PMID:27225895 NCBI chr20:12,754,490...12,768,454
Ensembl chr20:12,763,543...12,767,027
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of DIO3 mRNA CTD PMID:27225895 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dlgap1 DLG associated protein 1 increases expression EXP
ISO
Pravastatin results in increased expression of DLGAP1 mRNA CTD PMID:27225895 NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 affects farnesylation ISO Pravastatin affects the farnesylation of DNAJA1 protein CTD PMID:20884875 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dnase2b deoxyribonuclease 2 beta increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of DNASE2B mRNA
Pravastatin results in decreased expression of DNASE2B mRNA
CTD PMID:27225895 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP
ISO
Pravastatin results in increased expression of DPYSL2 mRNA CTD PMID:27225895 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of DTL mRNA
Pravastatin affects the expression of DTL mRNA
CTD PMID:27225895 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of ECH1 mRNA CTD PMID:27225895 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Edn1 endothelin 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of EDN1 protein
Pravastatin results in decreased expression of EDN1 mRNA; Pravastatin results in decreased expression of EDN1 protein
CTD PMID:12105140 PMID:19812503 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Efhb EF hand domain family, member B increases expression ISO
EXP
Pravastatin results in increased expression of EFHB mRNA CTD PMID:27225895 NCBI chr 9:6,372,191...6,441,678
Ensembl chr 9:6,372,194...6,441,919
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression EXP
ISO
Pravastatin results in decreased expression of EHHADH mRNA CTD PMID:27225895 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of ENPP5 mRNA
Pravastatin results in decreased expression of ENPP5 mRNA
CTD PMID:27225895 NCBI chr 9:16,910,187...16,917,633
Ensembl chr 9:16,910,831...16,917,480
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of ENTPD2 mRNA
Pravastatin results in increased expression of ENTPD2 mRNA
CTD PMID:27225895 NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of EPHX2 mRNA CTD PMID:27225895 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Ephx4 epoxide hydrolase 4 increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of EPHX4 mRNA
Pravastatin affects the expression of EPHX4 mRNA
CTD PMID:27225895 NCBI chr14:2,343,376...2,372,680
Ensembl chr14:2,340,248...2,373,022
JBrowse link
G Evi2a ecotropic viral integration site 2A decreases expression ISO
EXP
Pravastatin results in decreased expression of EVI2A mRNA CTD PMID:27225895 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
JBrowse link
G F13a1 coagulation factor XIII A1 chain decreases expression ISO
EXP
Pravastatin results in decreased expression of F13A1 mRNA CTD PMID:27225895 NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Pravastatin results in decreased expression of FABP1 mRNA CTD PMID:27225895 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of FABP2 mRNA
Pravastatin results in decreased expression of FABP2 mRNA
CTD PMID:27225895 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO
EXP
Pravastatin results in increased expression of FABP5 mRNA CTD PMID:27225895 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Far1 fatty acyl CoA reductase 1 increases expression EXP
ISO
Pravastatin results in increased expression of FAR1 mRNA CTD PMID:27225895 NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Pravastatin results in increased expression of FBN1 mRNA CTD PMID:27225895 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fbp2 fructose-bisphosphatase 2 affects expression EXP Pravastatin affects the expression of FBP2 mRNA CTD PMID:27225895 NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects activity ISO Pravastatin affects the activity of FDFT1 protein CTD PMID:8517861 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fgd2 FYVE, RhoGEF and PH domain containing 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of FGD2 mRNA CTD PMID:27225895 NCBI chr20:7,424,795...7,441,603
Ensembl chr20:7,424,790...7,441,603
JBrowse link
G Fgf13 fibroblast growth factor 13 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of FGF13 mRNA
Pravastatin results in increased expression of FGF13 mRNA
CTD PMID:27225895 NCBI chr  X:137,276,498...137,800,056
Ensembl chr  X:137,276,511...137,800,391
JBrowse link
G Flacc1 flagellum associated containing coiled-coil domains 1 increases expression EXP
ISO
Pravastatin results in increased expression of FLACC1 mRNA CTD PMID:27225895 NCBI chr 9:60,315,581...60,343,692
Ensembl chr 9:60,315,582...60,343,648
JBrowse link
G Flot1 flotillin 1 decreases expression ISO Pravastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978
JBrowse link
G Folr2 folate receptor beta decreases expression EXP
ISO
Pravastatin results in decreased expression of FOLR2 mRNA CTD PMID:27225895 NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724
JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation ISO Pravastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gck glucokinase decreases expression EXP Pravastatin results in decreased expression of GCK mRNA CTD PMID:27225895 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of GCLC mRNA
Pravastatin results in decreased expression of GCLC mRNA
CTD PMID:27225895 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of GCNT2 mRNA
Pravastatin results in decreased expression of GCNT2 mRNA
CTD PMID:27225895 NCBI chr17:23,796,859...23,901,625
NCBI chr17:23,866,602...23,868,691
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein] CTD PMID:20884875 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Gldc glycine decarboxylase decreases expression ISO
EXP
Pravastatin results in decreased expression of GLDC mRNA CTD PMID:27225895 NCBI chr 1:227,883,247...227,962,119
Ensembl chr 1:227,883,249...227,962,097
JBrowse link
G Gls2 glutaminase 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of GLS2 mRNA CTD PMID:27225895 NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426
JBrowse link
G Gpr85 G protein-coupled receptor 85 increases expression EXP
ISO
Pravastatin results in increased expression of GPR85 mRNA CTD PMID:27225895 NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of GSTK1 mRNA CTD PMID:27225895 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO
EXP
Pravastatin results in decreased expression of HADH mRNA CTD PMID:27225895 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP
ISO
Pravastatin results in decreased expression of HADHA mRNA CTD PMID:27225895 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP
ISO
Pravastatin results in decreased expression of HADHB mRNA CTD PMID:27225895 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP
ISO
Pravastatin results in increased expression of HAMP mRNA CTD PMID:27225895 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hax1 HCLS1 associated protein X-1 multiple interactions EXP Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein] CTD PMID:18483861 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases response to substance
increases expression
decreases activity
affects expression
ISO
EXP
HMGCR gene SNP results in decreased susceptibility to Pravastatin
Pravastatin results in increased expression of HMGCR mRNA
Pravastatin results in decreased activity of HMGCR protein
Pravastatin affects the expression of HMGCR mRNA
CTD PMID:8517861 PMID:8593127 PMID:15199031 PMID:27225895 PMID:29969672 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Pravastatin results in increased expression of HMGCS1 mRNA CTD PMID:27225895 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with pirinixic acid] results in increased expression of HMOX1 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Pravastatin results in increased expression of HMOX1 protein]; Pravastatin promotes the reaction [PPARA protein binds to HMOX1 promoter] CTD PMID:20368269 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hopx HOP homeobox decreases expression ISO
EXP
Pravastatin results in decreased expression of HOPX mRNA CTD PMID:27225895 NCBI chr14:31,055,912...31,082,909
Ensembl chr14:31,075,148...31,082,909
JBrowse link
G Hrg histidine-rich glycoprotein decreases expression ISO
EXP
Pravastatin results in decreased expression of HRG mRNA CTD PMID:27225895 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO
EXP
Pravastatin results in increased expression of HSD17B7 mRNA CTD PMID:27225895 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of HSDL2 mRNA
Pravastatin results in increased expression of HSDL2 mRNA
CTD PMID:27225895 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP
ISO
Pravastatin results in increased expression of IDI1 mRNA CTD PMID:27225895 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:18323514 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of IL1B mRNA
Pravastatin results in increased expression of IL1B mRNA
CTD PMID:27225895 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased secretion of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]
Pravastatin results in decreased expression of IL6 protein
CTD PMID:17729120 PMID:18323514 PMID:19330073 PMID:20884875 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO Pravastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein] CTD PMID:18323514 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions EXP
ISO
geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:12500026 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions EXP
ISO
geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:12500026 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb6 integrin subunit beta 6 affects expression ISO Pravastatin affects the expression of ITGB6 mRNA CTD PMID:27225895 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 increases expression ISO
EXP
Pravastatin results in increased expression of KCNS3 mRNA CTD PMID:27225895 NCBI chr 6:33,808,314...33,865,018
Ensembl chr 6:33,808,216...33,865,125
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of KCTD12 mRNA CTD PMID:27225895 NCBI chr15:79,800,077...79,806,064
Ensembl chr15:79,801,191...79,806,282
JBrowse link
G Kif20a kinesin family member 20A affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of KIF20A mRNA
Pravastatin results in decreased expression of KIF20A mRNA
CTD PMID:27225895 NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780
JBrowse link
G Kif20b kinesin family member 20B affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of KIF20B mRNA
Pravastatin results in decreased expression of KIF20B mRNA
CTD PMID:27225895 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
JBrowse link
G Kif23 kinesin family member 23 affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of KIF23 mRNA
Pravastatin results in decreased expression of KIF23 mRNA
CTD PMID:27225895 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Kitlg KIT ligand increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of KITLG mRNA
Pravastatin affects the expression of KITL mRNA
CTD PMID:27225895 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Klb klotho beta decreases expression ISO
EXP
Pravastatin results in decreased expression of KLB mRNA CTD PMID:27225895 NCBI chr14:42,899,050...42,950,788
Ensembl chr14:42,899,510...42,950,799
JBrowse link
G Krt23 keratin 23 decreases expression EXP
ISO
Pravastatin results in decreased expression of KRT23 mRNA CTD PMID:27225895 NCBI chr10:84,434,675...84,450,722
Ensembl chr10:84,434,380...84,450,983
JBrowse link
G Ldlr low density lipoprotein receptor increases activity
increases response to substance
multiple interactions
ISO Pravastatin results in increased activity of LDLR protein
[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased susceptibility to INS1 protein; LDLR gene mutant form results in increased susceptibility to Pravastatin
[LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BAX protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BCL2 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of INS1 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of STX1A protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of VAMP2 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased cleavage of CASP3 protein
CTD PMID:8593127 PMID:26875785 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lep leptin multiple interactions ISO Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lgals4 galectin 4 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of LGALS4 mRNA
Pravastatin results in decreased expression of LGALS4 mRNA
CTD PMID:27225895 NCBI chr 1:84,123,497...84,132,605
Ensembl chr 1:84,124,764...84,132,481
JBrowse link
G Lgi2 leucine-rich repeat LGI family, member 2 increases expression EXP
ISO
Pravastatin results in increased expression of LGI2 mRNA CTD PMID:27225895 NCBI chr14:58,415,965...58,443,450
Ensembl chr14:58,415,965...58,443,407
JBrowse link
G Lmna lamin A/C increases expression ISO Pravastatin results in increased expression of LMNA protein CTD PMID:20884875 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lpl lipoprotein lipase decreases expression EXP
ISO
Pravastatin results in decreased expression of LPL mRNA CTD PMID:27225895 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrmda leucine rich melanocyte differentiation associated decreases expression ISO Pravastatin results in decreased expression of LRMDA mRNA CTD PMID:27225895 NCBI chr15:1,223,098...2,284,764
Ensembl chr15:1,225,710...2,284,749
JBrowse link
G Lss lanosterol synthase increases expression EXP
ISO
Pravastatin results in increased expression of LSS mRNA CTD PMID:27225895 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 increases expression EXP
ISO
Pravastatin results in increased expression of LTBP2 mRNA CTD PMID:27225895 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
JBrowse link
G Ly86 lymphocyte antigen 86 decreases expression ISO
EXP
Pravastatin results in decreased expression of LY86 mRNA CTD PMID:27225895 NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260
JBrowse link
G Mapt microtubule-associated protein tau affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of MAPT
Pravastatin results in decreased expression of MAPT mRNA
CTD PMID:19461118 PMID:27225895 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of MASTL mRNA
Pravastatin results in decreased expression of MASTL mRNA
CTD PMID:27225895 NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353
JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation
increases expression
multiple interactions
ISO
EXP
Pravastatin results in increased phosphorylation of MDM2 protein
Pravastatin results in increased expression of MDM2 protein
[Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein; Sirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]; U 0126 inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]
CTD PMID:15625077 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Meiob meiosis specific with OB-fold decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of MEIOB mRNA
Pravastatin results in increased expression of MEIOB mRNA
CTD PMID:27225895 NCBI chr10:13,833,170...13,865,684
Ensembl chr10:13,833,750...13,865,046
JBrowse link
G Mgll monoglyceride lipase decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of MGLL mRNA
Pravastatin affects the expression of MGLL mRNA
CTD PMID:27225895 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Miox myo-inositol oxygenase decreases expression ISO Pravastatin results in decreased expression of MIOX mRNA CTD PMID:27225895 NCBI chr 7:120,405,031...120,407,529
Ensembl chr 7:120,405,031...120,407,537
JBrowse link
G Mis18a MIS18 kinetochore protein A increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of MIS18A mRNA
Pravastatin results in decreased expression of MIS18A mRNA
CTD PMID:27225895 NCBI chr11:29,968,030...29,981,058
Ensembl chr11:29,967,701...29,981,062
JBrowse link
G Mlycd malonyl-CoA decarboxylase decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of MLYCD mRNA
Pravastatin affects the expression of MLYCD mRNA
CTD PMID:27225895 NCBI chr19:47,447,931...47,463,794
Ensembl chr19:47,447,970...47,463,793
JBrowse link
G Mme membrane metallo-endopeptidase affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of MME mRNA
Pravastatin results in decreased expression of MME mRNA
CTD PMID:27225895 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression EXP Pravastatin results in decreased expression of MMP14 mRNA CTD PMID:16935385 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864