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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzannulene
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Accession:CHEBI:35641 term browser browse the term
Synonyms:related_synonym: dibenzannulenes


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amitriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression ISO Amitriptyline affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr 8:60,505,843...60,545,677
Ensembl chr 8:60,505,932...60,545,677
JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression ISO Amitriptyline results in decreased expression of ABAT mRNA CTD PMID:21820738 NCBI chr16:8,513,429...8,621,568
Ensembl chr16:8,513,429...8,621,568
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 decreases expression ISO Amitriptyline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects transport
affects expression
increases transport
EXP
ISO
ABCB1A protein affects the transport of Amitriptyline
Amitriptyline affects the expression of ABCB1 mRNA
ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite
CTD PMID:10700657, PMID:12082591, PMID:18355885 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcd2 ATP-binding cassette, sub-family D (ALD), member 2 decreases expression ISO Amitriptyline results in decreased expression of ABCD2 mRNA CTD PMID:22341215 NCBI chr15:91,145,871...91,192,007
Ensembl chr15:91,145,871...91,191,799
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO Amitriptyline results in decreased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr17:84,658,174...84,683,011
Ensembl chr17:84,658,234...84,683,011
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression ISO Amitriptyline results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr17:84,676,302...84,700,333
Ensembl chr17:84,676,302...84,700,333
JBrowse link
G Ache acetylcholinesterase decreases expression
increases activity
ISO
EXP
Amitriptyline results in decreased expression of ACHE mRNA
Amitriptyline results in increased activity of ACHE protein
CTD PMID:21820738, PMID:29614332 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 affects expression ISO Amitriptyline affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Ankrd1 ankyrin repeat domain 1 (cardiac muscle) increases expression ISO Amitriptyline results in increased expression of ANKRD1 mRNA CTD PMID:22341215 NCBI chr19:36,111,965...36,119,844
Ensembl chr19:36,111,961...36,120,099
JBrowse link
G Ano3 anoctamin 3 decreases expression ISO Amitriptyline results in decreased expression of ANO3 mRNA CTD PMID:22341215 NCBI chr 2:110,655,201...110,950,391
Ensembl chr 2:110,655,201...110,950,923
JBrowse link
G Ap1s1 adaptor protein complex AP-1, sigma 1 decreases expression ISO Amitriptyline results in decreased expression of AP1S1 mRNA CTD PMID:17175557, PMID:17567588 NCBI chr 5:137,034,993...137,046,108
Ensembl chr 5:137,034,993...137,046,135
JBrowse link
G Apoa4 apolipoprotein A-IV affects expression ISO Amitriptyline affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Arg1 arginase, liver increases expression ISO Amitriptyline results in increased expression of ARG1 mRNA CTD PMID:22341215 NCBI chr10:24,915,207...24,927,470
Ensembl chr10:24,915,221...24,927,484
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Amitriptyline results in increased expression of ASAH1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 8:41,340,646...41,397,644
Ensembl chr 8:41,340,197...41,374,773
JBrowse link
G Asns asparagine synthetase increases expression ISO Amitriptyline results in increased expression of ASNS mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Amitriptyline results in increased expression of ATF3 mRNA CTD PMID:22341215 NCBI chr 1:191,170,296...191,183,333
Ensembl chr 1:191,170,296...191,218,039
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bhmt betaine-homocysteine methyltransferase affects expression ISO Amitriptyline affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr13:93,616,891...93,637,758
Ensembl chr13:93,616,675...93,637,961
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide increases expression ISO Amitriptyline results in increased expression of C1QA mRNA CTD PMID:22341215 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G C1qc complement component 1, q subcomponent, C chain increases expression ISO Amitriptyline results in increased expression of C1QC mRNA CTD PMID:22341215 NCBI chr 4:136,889,801...136,892,936
Ensembl chr 4:136,889,804...136,893,065
JBrowse link
G Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 increases expression ISO Amitriptyline results in increased expression of CACNA2D1 mRNA CTD PMID:22341215 NCBI chr 5:15,934,264...16,374,511
Ensembl chr 5:15,934,691...16,374,511
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Amitriptyline results in increased expression of CASP3 mRNA
Amitriptyline results in increased activity of CASP3 protein
CTD PMID:16717317, PMID:19135049, PMID:19815060 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casr calcium-sensing receptor decreases expression ISO Amitriptyline results in decreased expression of CASR mRNA CTD PMID:22341215 NCBI chr16:36,490,585...36,562,141
Ensembl chr16:36,493,696...36,562,141
JBrowse link
G Cat catalase decreases expression ISO Amitriptyline results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) increases expression ISO Amitriptyline results in increased expression of CD74 mRNA CTD PMID:22341215 NCBI chr18:60,803,849...60,812,652
Ensembl chr18:60,803,848...60,812,652
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C affects expression ISO Amitriptyline affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 4:109,660,876...109,666,756
Ensembl chr 4:109,660,876...109,667,189
JBrowse link
G Ces2h carboxylesterase 2H affects expression ISO Amitriptyline affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr 8:105,000,830...105,020,410
Ensembl chr 8:105,000,853...105,021,178
JBrowse link
G Chat choline acetyltransferase increases expression ISO Amitriptyline results in increased expression of CHAT mRNA CTD PMID:21820738 NCBI chr14:32,408,203...32,465,909
Ensembl chr14:32,408,203...32,465,989
JBrowse link
G Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 decreases expression ISO Amitriptyline results in decreased expression of CHRNA3 mRNA CTD PMID:22341215 NCBI chr 9:55,010,117...55,026,562
Ensembl chr 9:55,010,111...55,026,562
JBrowse link
G Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) decreases expression
increases response to substance
ISO
EXP
Amitriptyline results in decreased expression of CHRNB2 mRNA
CHRNB2 protein results in increased susceptibility to Amitriptyline
CTD PMID:21820738, PMID:21905669 NCBI chr 3:89,753,448...89,764,632
Ensembl chr 3:89,746,195...89,764,632
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression ISO Amitriptyline affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 9:114,731,157...114,749,359
Ensembl chr 9:114,731,116...114,749,344
JBrowse link
G Cpne4 copine IV decreases expression ISO Amitriptyline results in decreased expression of CPNE4 mRNA CTD PMID:22341215 NCBI chr 9:104,566,701...105,034,544
Ensembl chr 9:104,547,286...105,034,544
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression ISO Amitriptyline affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr16:11,803,684...11,909,476
Ensembl chr16:11,803,721...11,909,445
JBrowse link
G Crem cAMP responsive element modulator affects expression ISO Amitriptyline affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 increases expression ISO Amitriptyline results in increased expression of CSRP3 mRNA CTD PMID:22341215 NCBI chr 7:48,830,398...48,848,051
Ensembl chr 7:48,830,398...48,848,033
JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions EXP Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein] CTD PMID:28633109 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD PMID:18359012, PMID:23397584, PMID:27320963 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 affects expression ISO Amitriptyline affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 7:26,931,631...26,939,413
Ensembl chr 7:26,931,631...26,939,384
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression
increases metabolic processing
ISO Amitriptyline results in increased expression of CYP2B1 mRNA
CYP2B6 protein results in increased metabolism of Amitriptyline
CTD PMID:10945841, PMID:27320963 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Amitriptyline results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
increases metabolic processing
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CYP2C19 protein results in increased metabolism of Amitriptyline
CTD PMID:23397584, PMID:27320963 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CTD PMID:23397584 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CTD PMID:23397584 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
increases metabolic processing
decreases activity
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline
Amitriptyline results in decreased activity of CYP2D6 protein
CTD PMID:16044105, PMID:18359012, PMID:18359183, PMID:23397584, PMID:27320963 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases metabolic processing
multiple interactions
ISO Amitriptyline results in increased metabolism of CYP3A4 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD PMID:18359012, PMID:23397584 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases metabolic processing ISO Amitriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Cyp4f14 cytochrome P450, family 4, subfamily f, polypeptide 14 affects expression ISO Amitriptyline affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr17:32,903,357...32,917,376
Ensembl chr17:32,905,070...32,917,342
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression ISO Amitriptyline affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr 1:172,148,015...172,196,393
Ensembl chr 1:172,148,084...172,197,005
JBrowse link
G Depp1 DEPP1 autophagy regulator increases expression ISO Amitriptyline results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 6:116,650,684...116,652,847
Ensembl chr 6:116,650,609...116,652,794
JBrowse link
G Des desmin multiple interactions EXP Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:23024785 NCBI chr 1:75,360,292...75,368,579
Ensembl chr 1:75,360,329...75,368,579
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 decreases activity ISO Amitriptyline results in decreased activity of DNMT1 protein CTD PMID:19924110 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Drd1 dopamine receptor D1 increases expression ISO Amitriptyline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr13:54,051,183...54,055,658
Ensembl chr13:54,051,183...54,055,705
JBrowse link
G Drd3 dopamine receptor D3 increases expression ISO Amitriptyline results in increased expression of DRD3 mRNA CTD PMID:21820738 NCBI chr16:43,754,015...43,825,982
Ensembl chr16:43,754,026...43,822,932
JBrowse link
G Ecel1 endothelin converting enzyme-like 1 increases expression ISO Amitriptyline results in increased expression of ECEL1 mRNA CTD PMID:22341215 NCBI chr 1:87,142,874...87,157,085
Ensembl chr 1:87,147,655...87,156,521
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression ISO Amitriptyline affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr15:102,073,773...102,097,173
Ensembl chr15:102,073,773...102,097,173
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal affects expression ISO Amitriptyline affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression ISO Amitriptyline affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr 5:121,444,753...121,452,474
Ensembl chr 5:121,428,590...121,452,506
JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO Amitriptyline results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 6:71,199,879...71,205,034
Ensembl chr 6:71,199,827...71,205,023
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 increases expression ISO Amitriptyline results in increased expression of FLRT3 mRNA CTD PMID:22341215 NCBI chr 2:140,658,198...140,671,476
Ensembl chr 2:140,650,914...140,671,469
JBrowse link
G Fmo3 flavin containing monooxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr 1:162,953,799...162,984,528
Ensembl chr 1:162,953,800...162,984,528
JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Amitriptyline results in increased expression of FNDC4 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 5:31,292,242...31,295,935
Ensembl chr 5:31,292,242...31,296,080
JBrowse link
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 increases expression
decreases expression
ISO Amitriptyline results in increased expression of GABRA1 mRNA
Amitriptyline results in decreased expression of GABRA1 mRNA
CTD PMID:21820738, PMID:22341215 NCBI chr11:42,130,939...42,183,066
Ensembl chr11:42,130,939...42,182,930
JBrowse link
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 increases expression ISO Amitriptyline results in increased expression of GABRA2 mRNA CTD PMID:21820738 NCBI chr 5:70,958,392...71,095,849
Ensembl chr 5:70,957,597...71,095,849
JBrowse link
G Gabra4 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 increases expression ISO Amitriptyline results in increased expression of GABRA4 mRNA CTD PMID:21820738 NCBI chr 5:71,569,734...71,658,308
Ensembl chr 5:71,569,749...71,658,308
JBrowse link
G Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 increases expression ISO Amitriptyline results in increased expression of GABRB3 mRNA CTD PMID:21820738 NCBI chr 7:57,590,518...57,828,802
Ensembl chr 7:57,419,692...57,828,802
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Amitriptyline results in increased expression of GADD45A mRNA CTD PMID:22341215 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression ISO Amitriptyline results in increased expression of GAL mRNA CTD PMID:22341215 NCBI chr19:3,409,915...3,414,544
Ensembl chr19:3,409,915...3,414,544
JBrowse link
G Gckr glucokinase regulatory protein affects expression ISO Amitriptyline affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 5:31,297,266...31,327,302
Ensembl chr 5:31,297,443...31,327,314
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Amitriptyline results in increased expression of GDPD3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 7:126,766,414...126,775,645
Ensembl chr 7:126,766,334...126,775,649
JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO Amitriptyline results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gls2 glutaminase 2 (liver, mitochondrial) affects expression ISO Amitriptyline affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr10:128,194,635...128,210,004
Ensembl chr10:128,194,457...128,210,004
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial affects expression ISO Amitriptyline affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr 8:95,864,133...95,888,401
Ensembl chr 8:95,864,134...95,888,547
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression ISO Amitriptyline affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 2:64,912,476...65,022,766
Ensembl chr 2:64,912,476...65,024,987
JBrowse link
G Grik1 glutamate receptor, ionotropic, kainate 1 decreases expression ISO Amitriptyline results in decreased expression of GRIK1 mRNA CTD PMID:22341215 NCBI chr16:87,895,901...88,290,863
Ensembl chr16:87,895,900...88,290,265
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases activity ISO Amitriptyline results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G H2-Ea histocompatibility 2, class II antigen E alpha increases expression ISO Amitriptyline results in increased expression of RT1-DA mRNA CTD PMID:22341215 NCBI chr17:34,341,952...34,344,645
Ensembl chr17:34,341,959...34,344,645
JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta increases expression ISO Amitriptyline results in increased expression of RT1-DB1 mRNA CTD PMID:22341215 NCBI chr17:34,305,867...34,316,674
Ensembl chr17:34,305,867...34,316,674
JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 affects expression ISO Amitriptyline affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr17:36,029,977...36,032,701
Ensembl chr17:36,029,773...36,032,855
JBrowse link
G Hal histidine ammonia lyase affects expression ISO Amitriptyline affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr10:93,488,768...93,516,761
Ensembl chr10:93,488,768...93,519,304
JBrowse link
G Hmgb2 high mobility group box 2 affects expression ISO Amitriptyline affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr 8:57,511,843...57,515,999
Ensembl chr 8:57,511,907...57,515,999
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 increases expression ISO Amitriptyline results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr13:119,690,351...119,708,260
Ensembl chr13:119,690,379...119,708,260
JBrowse link
G Hoxd1 homeobox D1 decreases expression ISO Amitriptyline results in decreased expression of HOXD1 mRNA CTD PMID:22341215 NCBI chr 2:74,762,980...74,765,142
Ensembl chr 2:74,762,980...74,765,142
JBrowse link
G Hpn hepsin increases expression ISO Amitriptyline results in increased expression of HPN mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 7:31,098,725...31,115,326
Ensembl chr 7:31,098,725...31,115,290
JBrowse link
G Hpse heparanase decreases expression ISO Amitriptyline results in decreased expression of HPSE mRNA CTD PMID:22341215 NCBI chr 5:100,679,484...100,719,716
Ensembl chr 5:100,679,484...100,719,716
JBrowse link
G Hs3st2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 decreases expression ISO Amitriptyline results in decreased expression of HS3ST2 mRNA CTD PMID:22341215 NCBI chr 7:121,391,585...121,501,768
Ensembl chr 7:121,391,859...121,501,770
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A increases expression ISO Amitriptyline results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Htr1d 5-hydroxytryptamine (serotonin) receptor 1D decreases expression ISO Amitriptyline results in decreased expression of HTR1D mRNA CTD PMID:22341215 NCBI chr 4:136,423,522...136,444,405
Ensembl chr 4:136,423,524...136,444,398
JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C affects binding ISO Amitriptyline binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:146,962,464...147,197,277
Ensembl chr  X:146,962,513...147,197,277
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il33 interleukin 33 affects expression ISO Amitriptyline affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr19:29,925,113...29,960,718
Ensembl chr19:29,925,114...29,960,718
JBrowse link
G Inhbe inhibin beta-E increases expression ISO Amitriptyline results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr10:127,349,402...127,351,848
Ensembl chr10:127,348,857...127,354,411
JBrowse link
G Itgb6 integrin beta 6 decreases expression ISO Amitriptyline results in decreased expression of ITGB6 mRNA CTD PMID:22341215 NCBI chr 2:60,598,292...60,722,603
Ensembl chr 2:60,598,292...60,722,643
JBrowse link
G Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 decreases expression ISO Amitriptyline results in decreased expression of KCNA4 mRNA CTD PMID:22341215 NCBI chr 2:107,290,589...107,326,804
Ensembl chr 2:107,290,639...107,298,502
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963, PMID:21158687 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 decreases activity ISO Amitriptyline results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:45,268,750...45,685,887
Ensembl chr18:45,268,860...45,686,024
JBrowse link
G Kcns1 K+ voltage-gated channel, subfamily S, 1 decreases expression ISO Amitriptyline results in decreased expression of KCNS1 mRNA CTD PMID:22341215 NCBI chr 2:164,163,619...164,171,113
Ensembl chr 2:164,163,619...164,171,113
JBrowse link
G Kcns3 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 decreases expression ISO Amitriptyline results in decreased expression of KCNS3 mRNA CTD PMID:22341215 NCBI chr12:11,090,202...11,151,168
Ensembl chr12:11,090,202...11,151,056
JBrowse link
G Lox lysyl oxidase affects expression ISO Amitriptyline affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:52,516,060...52,529,867
Ensembl chr18:52,516,067...52,529,867
JBrowse link
G Lss lanosterol synthase increases expression ISO Amitriptyline results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr10:76,531,565...76,557,139
Ensembl chr10:76,531,588...76,557,138
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression ISO Amitriptyline affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr13:56,073,622...56,135,626
Ensembl chr13:56,073,619...56,136,361
JBrowse link
G Manba mannosidase, beta A, lysosomal affects expression ISO Amitriptyline affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 3:135,485,611...135,571,404
Ensembl chr 3:135,485,611...135,571,404
JBrowse link
G Maoa monoamine oxidase A affects expression ISO Amitriptyline affects the expression of MAOA mRNA CTD PMID:21820738 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Mlx MAX-like protein X affects expression ISO Amitriptyline affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr11:101,086,707...101,092,207
Ensembl chr11:101,087,277...101,092,207
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression ISO Amitriptyline results in increased expression of MMP16 mRNA CTD PMID:22341215 NCBI chr 4:17,853,072...18,117,479
Ensembl chr 4:17,852,893...18,119,145
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression ISO Amitriptyline affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr17:35,910,380...35,916,440
Ensembl chr17:35,910,379...35,916,389
JBrowse link
G Msmo1 methylsterol monoxygenase 1 affects expression ISO Amitriptyline affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr 8:64,718,123...64,733,578
Ensembl chr 8:64,718,139...64,733,792
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Nmb neuromedin B decreases expression ISO Amitriptyline results in decreased expression of NMB mRNA CTD PMID:22341215 NCBI chr 7:80,902,227...80,905,062
Ensembl chr 7:80,902,227...80,905,076
JBrowse link
G Nmur1 neuromedin U receptor 1 decreases expression ISO Amitriptyline results in decreased expression of NMUR1 mRNA CTD PMID:21820738 NCBI chr 1:86,386,242...86,389,361
Ensembl chr 1:86,386,303...86,426,228
JBrowse link
G Nog noggin decreases expression ISO Amitriptyline results in decreased expression of NOG mRNA CTD PMID:22341215 NCBI chr11:89,300,638...89,302,559
Ensembl chr11:89,300,638...89,302,332
JBrowse link
G Nphs2 nephrosis 2, podocin multiple interactions EXP Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:23024785 NCBI chr 1:156,310,535...156,328,035
Ensembl chr 1:156,310,727...156,328,035
JBrowse link
G Npy neuropeptide Y increases expression ISO Amitriptyline results in increased expression of NPY mRNA CTD PMID:22341215 NCBI chr 6:49,822,710...49,829,507
Ensembl chr 6:49,822,710...49,829,507
JBrowse link
G Npy5r neuropeptide Y receptor Y5 increases expression ISO Amitriptyline results in increased expression of NPY5R mRNA CTD PMID:21820738 NCBI chr 8:66,679,965...66,688,094
Ensembl chr 8:66,679,965...66,688,128
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amitriptyline results in increased expression of NR0B2 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance EXP NR3C1 protein affects the susceptibility to Amitriptyline CTD PMID:11226678 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression ISO Amitriptyline results in increased expression of NR3C2 mRNA CTD PMID:12393271 NCBI chr 8:76,898,083...77,245,012
Ensembl chr 8:76,899,442...77,245,012
JBrowse link
G Nrep neuronal regeneration related protein affects expression ISO Amitriptyline affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:33,437,019...33,464,365
Ensembl chr18:33,437,019...33,464,029
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Amitriptyline results in decreased expression of NTNG1 mRNA CTD PMID:22341215 NCBI chr 3:109,780,050...110,149,972
Ensembl chr 3:109,780,040...110,144,011
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO Amitriptyline results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861
JBrowse link
G Oaf out at first homolog affects expression ISO Amitriptyline affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 9:43,221,278...43,239,816
Ensembl chr 9:43,221,235...43,239,911
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Amitriptyline results in decreased expression of PATJ mRNA CTD PMID:22341215 NCBI chr 4:98,395,560...98,719,603
Ensembl chr 4:98,395,785...98,719,603
JBrowse link
G Pcx pyruvate carboxylase affects expression ISO Amitriptyline affects the expression of PC mRNA CTD PMID:18355885 NCBI chr19:4,510,472...4,621,752
Ensembl chr19:4,510,472...4,621,752
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression ISO Amitriptyline affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 1:72,259,172...72,284,321
Ensembl chr 1:72,259,167...72,284,314
JBrowse link
G Phyh phytanoyl-CoA hydroxylase increases expression ISO Amitriptyline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr 2:4,918,996...4,938,743
Ensembl chr 2:4,919,019...4,938,730
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Amitriptyline results in decreased expression of PLCD4 mRNA CTD PMID:22341215 NCBI chr 1:74,541,975...74,565,977
Ensembl chr 1:74,542,888...74,567,794
JBrowse link
G Plpp4 phospholipid phosphatase 4 decreases expression ISO Amitriptyline results in decreased expression of PLPP4 mRNA CTD PMID:22341215 NCBI chr 7:129,256,390...129,391,412
Ensembl chr 7:129,257,031...129,391,412
JBrowse link
G Por P450 (cytochrome) oxidoreductase affects expression ISO Amitriptyline affects the expression of POR mRNA CTD PMID:18355885 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
G Prokr1 prokineticin receptor 1 decreases expression ISO Amitriptyline results in decreased expression of PROKR1 mRNA CTD PMID:21820738 NCBI chr 6:87,578,586...87,590,762
Ensembl chr 6:87,578,591...87,590,743
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein] CTD PMID:28633109 NCBI chr 7:127,991,373...127,993,867
Ensembl chr 7:127,989,708...127,993,867
JBrowse link
G Rasd1 RAS, dexamethasone-induced 1 increases expression ISO Amitriptyline results in increased expression of RASD1 mRNA CTD PMID:22341215 NCBI chr11:59,963,181...59,964,944
Ensembl chr11:59,963,181...59,964,944
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression ISO Amitriptyline affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr 8:91,070,057...91,123,844
Ensembl chr 8:91,070,057...91,123,844
JBrowse link
G Reg3b regenerating islet-derived 3 beta increases expression ISO Amitriptyline results in increased expression of REG3B mRNA CTD PMID:22341215 NCBI chr 6:78,370,885...78,373,466
Ensembl chr 6:78,370,657...78,373,466
JBrowse link
G Rnf112 ring finger protein 112 decreases expression ISO Amitriptyline results in decreased expression of RNF112 mRNA CTD PMID:22341215 NCBI chr11:61,448,417...61,454,188
Ensembl chr11:61,448,442...61,454,131
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Amitriptyline results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr19:44,293,676...44,306,864
Ensembl chr19:44,293,674...44,306,864
JBrowse link
G Scn11a sodium channel, voltage-gated, type XI, alpha decreases expression ISO Amitriptyline results in decreased expression of SCN11A mRNA CTD PMID:22341215 NCBI chr 9:119,753,763...119,825,456
Ensembl chr 9:119,753,759...119,825,456
JBrowse link
G Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A increases expression ISO Amitriptyline results in increased expression of SEMA6A mRNA CTD PMID:22341215 NCBI chr18:47,245,254...47,371,200
Ensembl chr18:47,235,598...47,368,870
JBrowse link
G Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B increases expression ISO Amitriptyline results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr12:104,127,986...104,139,546
Ensembl chr12:104,127,996...104,139,545
JBrowse link
G Sh3gl3 SH3-domain GRB2-like 3 affects expression ISO Amitriptyline affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 7:82,173,808...82,307,420
Ensembl chr 7:82,173,840...82,307,419
JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions
decreases activity
ISO Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
Amitriptyline results in decreased activity of SLC22A1 protein
CTD PMID:30189235, PMID:31364238 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions
decreases activity
ISO Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Amitriptyline results in decreased activity of SLC22A2 protein
CTD PMID:21599003, PMID:23770354, PMID:28629854, PMID:30189235, PMID:31364238 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions ISO Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299
JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 decreases expression ISO Amitriptyline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640
JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] CTD PMID:28629854 NCBI chr11:61,301,627...61,342,860
Ensembl chr11:61,301,631...61,342,860
JBrowse link
G Slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 affects expression ISO Amitriptyline affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 6:91,684,048...91,759,063
Ensembl chr 6:91,684,053...91,759,066
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression ISO Amitriptyline affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 6:141,805,438...141,856,284
Ensembl chr 6:141,805,440...141,856,199
JBrowse link
G Smagp small cell adhesion glycoprotein increases expression ISO Amitriptyline results in increased expression of SMAGP mRNA CTD PMID:22341215 NCBI chr15:100,621,339...100,636,940
Ensembl chr15:100,621,339...100,636,940
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal increases response to substance
multiple interactions
decreases activity
EXP
ISO
SMPD1 protein results in increased susceptibility to Amitriptyline
[Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein
Amitriptyline results in decreased activity of SMPD1 protein
CTD PMID:23770692 NCBI chr 7:105,554,360...105,558,389
Ensembl chr 7:105,554,360...105,558,389
JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO Amitriptyline results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing decreases expression ISO Amitriptyline results in decreased expression of SORL1 mRNA CTD PMID:22341215 NCBI chr 9:41,964,709...42,124,297
Ensembl chr 9:41,964,720...42,124,297
JBrowse link
G Sox11 SRY (sex determining region Y)-box 11 increases expression ISO Amitriptyline results in increased expression of SOX11 mRNA CTD PMID:22341215 NCBI chr12:27,334,268...27,342,718
Ensembl chr12:27,334,264...27,342,574
JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO Amitriptyline results in increased expression of SPRR1A mRNA CTD PMID:22341215 NCBI chr 3:92,483,954...92,485,881
Ensembl chr 3:92,483,952...92,485,895
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Srebf2 sterol regulatory element binding factor 2 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr15:82,147,269...82,205,379
Ensembl chr15:82,147,181...82,205,379
JBrowse link
G Sstr1 somatostatin receptor 1 decreases expression ISO Amitriptyline results in decreased expression of SSTR1 mRNA CTD PMID:21820738 NCBI chr12:58,211,421...58,216,037
Ensembl chr12:58,211,772...58,214,444
JBrowse link
G St13 suppression of tumorigenicity 13 affects expression ISO Amitriptyline affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr15:81,365,044...81,399,694
Ensembl chr15:81,363,669...81,400,077
JBrowse link
G Stac2 SH3 and cysteine rich domain 2 increases expression ISO Amitriptyline results in increased expression of STAC2 mRNA CTD PMID:22341215 NCBI chr11:98,036,623...98,053,462
Ensembl chr11:98,036,623...98,053,462
JBrowse link
G Stbd1 starch binding domain 1 affects expression ISO Amitriptyline affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr 5:92,603,051...92,606,579
Ensembl chr 5:92,603,041...92,606,579
JBrowse link
G Stmn1 stathmin 1 affects expression ISO Amitriptyline affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 4:134,468,320...134,473,843
Ensembl chr 4:134,468,320...134,473,843
JBrowse link
G Stmn4 stathmin-like 4 increases expression ISO Amitriptyline results in increased expression of STMN4 mRNA CTD PMID:22341215 NCBI chr14:66,344,210...66,361,680
Ensembl chr14:66,344,296...66,361,680
JBrowse link
G Tagln transgelin decreases expression ISO Amitriptyline results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 9:45,929,628...45,936,058
Ensembl chr 9:45,929,619...45,936,058
JBrowse link
G Tex261 testis expressed gene 261 affects expression ISO Amitriptyline affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 6:83,768,881...83,776,099
Ensembl chr 6:83,768,885...83,775,813
JBrowse link
G Tgm1 transglutaminase 1, K polypeptide increases expression ISO Amitriptyline results in increased expression of TGM1 mRNA CTD PMID:22341215 NCBI chr14:55,700,009...55,713,921
Ensembl chr14:55,700,009...55,713,926
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression ISO Amitriptyline affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 7:105,640,445...105,655,748
Ensembl chr 7:105,640,056...105,643,637
Ensembl chr 7:105,640,056...105,643,637
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 6:92,242,061...92,244,650
Ensembl chr 6:92,242,061...92,244,650
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 3:102,777,398...102,789,082
Ensembl chr 3:102,775,465...102,782,718
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO Amitriptyline affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr 8:70,508,263...70,510,417
Ensembl chr 8:70,508,263...70,510,801
Ensembl chr 4:70,508,263...70,510,801
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 affects expression ISO Amitriptyline affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 affects expression ISO Amitriptyline affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr 5:87,459,490...87,490,871
Ensembl chr 5:87,459,490...87,490,871
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 affects expression ISO Amitriptyline affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr 5:86,916,639...86,926,503
Ensembl chr 5:86,916,638...86,926,530
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein] CTD PMID:23024785 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Amitriptyline results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr11:109,573,521...109,611,389
Ensembl chr11:109,573,331...109,611,967
JBrowse link
cyclobenzaprine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
nortriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects response to substance
increases transport
ISO
EXP
ABCB1 exon SNP affects the susceptibility to Nortriptyline
ABCB1A protein results in increased transport of Nortriptyline; ABCB1A protein results in increased transport of Nortriptyline metabolite
CTD PMID:10700657, PMID:12082591 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 decreases activity ISO Nortriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Casp3 caspase 3 decreases activity
increases activity
multiple interactions
EXP
ISO
Nortriptyline results in decreased activity of CASP3 protein
Nortriptyline results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein]
CTD PMID:17686041, PMID:18174477, PMID:22700542 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Cycs cytochrome c, somatic decreases secretion EXP Nortriptyline results in decreased secretion of CYCS protein CTD PMID:17686041 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP1A2 protein CTD PMID:18359012 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity
multiple interactions
ISO Nortriptyline results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]
CTD PMID:15304522 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases response to substance
multiple interactions
increases metabolic processing
increases hydroxylation
ISO CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline
Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline]
Nortriptyline results in increased metabolism of CYP2D6 protein
CYP2D6 protein results in increased hydroxylation of Nortriptyline
CTD PMID:11673748, PMID:17470523, PMID:18359012 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP3A4 protein CTD PMID:18359012 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 increases metabolic processing ISO Nortriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr 5:137,892,933...137,925,610
Ensembl chr 5:137,892,932...137,921,619
JBrowse link
G Gnb3 guanine nucleotide binding protein (G protein), beta 3 decreases response to substance
increases response to substance
ISO GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline
GNB3 protein results in increased susceptibility to Nortriptyline
CTD PMID:14604448 NCBI chr 6:124,834,240...124,840,275
Ensembl chr 6:124,834,240...124,840,275
JBrowse link
G Htr2c 5-hydroxytryptamine (serotonin) receptor 2C decreases expression ISO Nortriptyline results in decreased expression of HTR2C protein CTD PMID:8131152 NCBI chr  X:146,962,464...147,197,277
Ensembl chr  X:146,962,513...147,197,277
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions ISO Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Pf4 platelet factor 4 affects expression ISO Nortriptyline affects the expression of PF4 protein CTD PMID:10770450 NCBI chr 5:90,772,435...90,773,383
Ensembl chr 5:90,772,435...90,773,383
JBrowse link
G Ppbp pro-platelet basic protein affects expression ISO Nortriptyline affects the expression of PPBP protein CTD PMID:10770450 NCBI chr 5:90,768,518...90,770,063
Ensembl chr 5:90,768,518...90,770,063
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Nortriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 affects response to substance ISO SLC6A2 gene polymorphism affects the susceptibility to Nortriptyline CTD PMID:17018806 NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 affects response to substance
increases response to substance
decreases response to substance
ISO SLC6A4 polymorphism affects the susceptibility to Nortriptyline; SLC6A4 promoter polymorphism affects the susceptibility to Nortriptyline
SLC6A4 protein results in increased susceptibility to Nortriptyline
SLC6A4 gene polymorphism results in decreased susceptibility to Nortriptyline
CTD PMID:14604448, PMID:17018806, PMID:21658141 NCBI chr11:76,998,597...77,032,343
Ensembl chr11:76,998,603...77,032,340
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
protriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 decreases activity ISO Protriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 decreases expression EXP Protriptyline results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21538
    role 21517
      biological role 21516
        aetiopathogenetic role 20603
          carcinogenic agent 19300
            polycyclic arene 17663
              ortho-fused polycyclic arene 9906
                dibenzannulene 186
                  1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole + 0
                  dibenzo[a,d][7]annulene + 186
Path 2
Term Annotations click to browse term
  CHEBI ontology 21538
    subatomic particle 21525
      composite particle 21525
        hadron 21525
          baryon 21525
            nucleon 21525
              atomic nucleus 21525
                atom 21525
                  main group element atom 21426
                    main group molecular entity 21426
                      s-block molecular entity 20942
                        hydrogen molecular entity 20866
                          hydrides 20090
                            organic hydride 19584
                              organic fundamental parent 19584
                                hydrocarbon 19419
                                  cyclic hydrocarbon 17887
                                    arene 17883
                                      polycyclic arene 17663
                                        ortho-fused polycyclic arene 9906
                                          dibenzannulene 186
                                            1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole + 0
                                            dibenzo[a,d][7]annulene + 186
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.