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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenzannulene
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Accession:CHEBI:35641 term browser browse the term
Synonyms:related_synonym: dibenzannulenes


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amitriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase affects expression ISO Amitriptyline affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr 4:170,060,222...170,091,699
Ensembl chr 4:170,060,222...170,091,699
JBrowse link
G ABAT 4-aminobutyrate aminotransferase decreases expression ISO Amitriptyline results in decreased expression of ABAT mRNA CTD PMID:21820738 NCBI chr16:8,674,617...8,784,570
Ensembl chr16:8,674,596...8,784,575
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects transport
affects expression
increases transport
ISO ABCB1A protein affects the transport of Amitriptyline
Amitriptyline affects the expression of ABCB1 mRNA
ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite
CTD PMID:10700657 PMID:12082591 PMID:18355885 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 decreases expression ISO Amitriptyline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 2:168,915,468...169,031,396
Ensembl chr 2:168,915,498...169,031,324
JBrowse link
G ABCD2 ATP binding cassette subfamily D member 2 decreases expression ISO Amitriptyline results in decreased expression of ABCD2 mRNA CTD PMID:22341215 NCBI chr12:39,530,965...39,651,333
Ensembl chr12:39,550,033...39,619,803
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 decreases expression ISO Amitriptyline results in decreased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 2:43,806,154...43,838,840
Ensembl chr 2:43,812,472...43,838,865
JBrowse link
G ABCG8 ATP binding cassette subfamily G member 8 decreases expression ISO Amitriptyline results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 2:43,831,942...43,882,988
Ensembl chr 2:43,831,942...43,882,988
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) decreases expression
increases activity
ISO Amitriptyline results in decreased expression of ACHE mRNA
Amitriptyline results in increased activity of ACHE protein
CTD PMID:21820738 PMID:29614332 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 affects expression ISO Amitriptyline affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ANKRD1 ankyrin repeat domain 1 increases expression ISO Amitriptyline results in increased expression of ANKRD1 mRNA CTD PMID:22341215 NCBI chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087
Ensembl chr10:90,912,096...90,921,087
JBrowse link
G ANO3 anoctamin 3 decreases expression ISO Amitriptyline results in decreased expression of ANO3 mRNA CTD PMID:22341215 NCBI chr11:26,188,808...26,667,907
Ensembl chr11:26,188,842...26,663,289
JBrowse link
G AP1S1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP Amitriptyline results in decreased expression of AP1S1 mRNA CTD PMID:17175557 PMID:17567588 NCBI chr 7:101,154,476...101,161,276
Ensembl chr 7:101,154,456...101,161,596
JBrowse link
G APOA4 apolipoprotein A4 affects expression ISO Amitriptyline affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
JBrowse link
G ARG1 arginase 1 increases expression ISO Amitriptyline results in increased expression of ARG1 mRNA CTD PMID:22341215 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 increases expression EXP Amitriptyline results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Amitriptyline results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ATF3 activating transcription factor 3 increases expression ISO Amitriptyline results in increased expression of ATF3 mRNA CTD PMID:22341215 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BHMT betaine--homocysteine S-methyltransferase affects expression ISO Amitriptyline affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
JBrowse link
G C1QA complement C1q A chain increases expression ISO Amitriptyline results in increased expression of C1QA mRNA CTD PMID:22341215 NCBI chr 1:22,636,463...22,639,678
Ensembl chr 1:22,636,628...22,639,678
JBrowse link
G C1QC complement C1q C chain increases expression ISO Amitriptyline results in increased expression of C1QC mRNA CTD PMID:22341215 NCBI chr 1:22,643,633...22,648,108
Ensembl chr 1:22,643,633...22,648,110
JBrowse link
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression ISO Amitriptyline results in increased expression of CACNA2D1 mRNA CTD PMID:22341215 NCBI chr 7:81,946,444...82,443,956
Ensembl chr 7:81,946,444...82,443,777
JBrowse link
G CASP1 caspase 1 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases activity
ISO Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Amitriptyline results in increased expression of CASP3 mRNA
Amitriptyline results in increased activity of CASP3 protein
CTD PMID:16717317 PMID:19135049 PMID:19815060 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASR calcium sensing receptor decreases expression ISO Amitriptyline results in decreased expression of CASR mRNA CTD PMID:22341215 NCBI chr 3:122,183,668...122,291,629
Ensembl chr 3:122,183,683...122,291,629
Ensembl chr 3:122,183,683...122,291,629
JBrowse link
G CAT catalase decreases expression EXP Amitriptyline results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CD74 CD74 molecule increases expression ISO Amitriptyline results in increased expression of CD74 mRNA CTD PMID:22341215 NCBI chr 5:150,400,041...150,412,936
Ensembl chr 5:150,400,041...150,412,929
JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C affects expression ISO Amitriptyline affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634
JBrowse link
G CES2 carboxylesterase 2 affects expression ISO Amitriptyline affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
JBrowse link
G CHAT choline O-acetyltransferase increases expression ISO Amitriptyline results in increased expression of CHAT mRNA CTD PMID:21820738 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,665,104
Ensembl chr10:49,609,095...49,665,104
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit decreases expression ISO Amitriptyline results in decreased expression of CHRNA3 mRNA CTD PMID:22341215 NCBI chr15:78,593,052...78,620,996
Ensembl chr15:78,593,052...78,621,295
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit decreases expression
increases response to substance
ISO Amitriptyline results in decreased expression of CHRNB2 mRNA
CHRNB2 protein results in increased susceptibility to Amitriptyline
CTD PMID:21820738 PMID:21905669 NCBI chr 1:154,567,778...154,584,708
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G CMTM6 CKLF like MARVEL transmembrane domain containing 6 affects expression ISO Amitriptyline affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 3:32,481,312...32,502,852
Ensembl chr 3:32,481,312...32,502,852
JBrowse link
G CPNE4 copine 4 decreases expression ISO Amitriptyline results in decreased expression of CPNE4 mRNA CTD PMID:22341215 NCBI chr 3:131,533,569...132,285,696
Ensembl chr 3:131,533,555...132,285,410
JBrowse link
G CPPED1 calcineurin like phosphoesterase domain containing 1 affects expression ISO Amitriptyline affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr16:12,659,799...12,803,887
Ensembl chr16:12,659,799...12,803,887
JBrowse link
G CREM cAMP responsive element modulator affects expression ISO Amitriptyline affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr10:35,126,830...35,212,958
Ensembl chr10:35,126,791...35,212,958
JBrowse link
G CSRP3 cysteine and glycine rich protein 3 increases expression ISO Amitriptyline results in increased expression of CSRP3 mRNA CTD PMID:22341215 NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein] CTD PMID:28633109 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases metabolic processing
multiple interactions
EXP Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD PMID:18359012 PMID:23397584 PMID:27320963 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases metabolic processing EXP CYP2B6 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
increases metabolic processing
EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CYP2C19 protein results in increased metabolism of Amitriptyline
CTD PMID:23397584 PMID:27320963 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CTD PMID:23397584 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases activity
multiple interactions
increases metabolic processing
EXP Amitriptyline results in decreased activity of CYP2D6 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline
CTD PMID:16044105 PMID:18359012 PMID:18359183 PMID:23397584 PMID:27320963 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases metabolic processing
multiple interactions
EXP Amitriptyline results in increased metabolism of CYP3A4 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD PMID:18359012 PMID:23397584 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases metabolic processing EXP Amitriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G DCAF8 DDB1 and CUL4 associated factor 8 affects expression ISO Amitriptyline affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr 1:160,215,720...160,262,549
Ensembl chr 1:160,215,715...160,262,549
Ensembl chr 1:160,215,715...160,262,549
JBrowse link
G DEPP1 DEPP1 autophagy regulator increases expression EXP Amitriptyline results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809
JBrowse link
G DES desmin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:23024785 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,734
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases activity ISO Amitriptyline results in decreased activity of DNMT1 protein CTD PMID:19924110 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DRD1 dopamine receptor D1 increases expression ISO Amitriptyline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
JBrowse link
G DRD3 dopamine receptor D3 increases expression ISO Amitriptyline results in increased expression of DRD3 mRNA CTD PMID:21820738 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G ECEL1 endothelin converting enzyme like 1 increases expression ISO Amitriptyline results in increased expression of ECEL1 mRNA CTD PMID:22341215 NCBI chr 2:232,479,827...232,487,834
Ensembl chr 2:232,479,827...232,487,834
JBrowse link
G EIF4B eukaryotic translation initiation factor 4B affects expression ISO Amitriptyline affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr12:53,006,456...53,042,215
Ensembl chr12:53,006,282...53,042,215
Ensembl chr12:53,006,282...53,042,215
JBrowse link
G EPHX1 epoxide hydrolase 1 affects expression ISO Amitriptyline affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G ERP29 endoplasmic reticulum protein 29 affects expression ISO Amitriptyline affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:112,013,340...112,023,449
Ensembl chr12:112,013,348...112,023,449
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Amitriptyline results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FLRT3 fibronectin leucine rich transmembrane protein 3 increases expression ISO Amitriptyline results in increased expression of FLRT3 mRNA CTD PMID:22341215 NCBI chr20:14,322,985...14,337,847
Ensembl chr20:14,322,985...14,337,614
JBrowse link
G FMO3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing EXP FMO3 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr 1:171,090,873...171,117,819
Ensembl chr 1:171,090,901...171,117,819
JBrowse link
G FNDC4 fibronectin type III domain containing 4 increases expression EXP Amitriptyline results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 2:27,491,883...27,495,502
Ensembl chr 2:27,491,883...27,495,200
JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 increases expression
decreases expression
ISO Amitriptyline results in increased expression of GABRA1 mRNA
Amitriptyline results in decreased expression of GABRA1 mRNA
CTD PMID:21820738 PMID:22341215 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981
JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 increases expression ISO Amitriptyline results in increased expression of GABRA2 mRNA CTD PMID:21820738 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230
Ensembl chr 4:46,243,548...46,475,230
JBrowse link
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 increases expression ISO Amitriptyline results in increased expression of GABRA4 mRNA CTD PMID:21820738 NCBI chr 4:46,918,900...46,993,581
Ensembl chr 4:46,918,900...46,993,581
JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 increases expression ISO Amitriptyline results in increased expression of GABRB3 mRNA CTD PMID:21820738 NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,546...26,939,539
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression ISO Amitriptyline results in increased expression of GADD45A mRNA CTD PMID:22341215 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GAL galanin and GMAP prepropeptide increases expression ISO Amitriptyline results in increased expression of GAL mRNA CTD PMID:22341215 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GCKR glucokinase regulator affects expression ISO Amitriptyline affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 2:27,496,839...27,523,689
Ensembl chr 2:27,496,839...27,523,684
JBrowse link
G GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression EXP Amitriptyline results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr16:30,104,810...30,113,537
Ensembl chr16:30,104,810...30,113,537
JBrowse link
G GFAP glial fibrillary acidic protein increases expression ISO Amitriptyline results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GLS2 glutaminase 2 affects expression ISO Amitriptyline affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr12:56,470,952...56,488,161
Ensembl chr12:56,470,944...56,488,414
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 affects expression ISO Amitriptyline affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342
JBrowse link
G GRB14 growth factor receptor bound protein 14 affects expression ISO Amitriptyline affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 2:164,492,417...164,622,959
Ensembl chr 2:164,492,417...164,621,482
JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 decreases expression ISO Amitriptyline results in decreased expression of GRIK1 mRNA CTD PMID:22341215 NCBI chr21:29,536,933...29,939,996
Ensembl chr21:29,536,933...29,940,033
JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity EXP Amitriptyline results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HAL histidine ammonia-lyase affects expression ISO Amitriptyline affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365
JBrowse link
G HLA-DRA major histocompatibility complex, class II, DR alpha increases expression ISO Amitriptyline results in increased expression of RT1-DA mRNA CTD PMID:22341215 NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 increases expression ISO Amitriptyline results in increased expression of RT1-DB1 mRNA CTD PMID:22341215 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G HLA-E major histocompatibility complex, class I, E affects expression ISO Amitriptyline affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr 6:30,489,508...30,494,194
Ensembl chr 6:30,489,509...30,494,194
JBrowse link
G HMGB2 high mobility group box 2 affects expression ISO Amitriptyline affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP Amitriptyline results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 5:43,287,470...43,313,477
Ensembl chr 5:43,287,470...43,313,512
JBrowse link
G HOXD1 homeobox D1 decreases expression ISO Amitriptyline results in decreased expression of HOXD1 mRNA CTD PMID:22341215 NCBI chr 2:176,188,668...176,190,907
Ensembl chr 2:176,188,668...176,190,907
JBrowse link
G HPN hepsin increases expression EXP Amitriptyline results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,571
JBrowse link
G HPSE heparanase decreases expression ISO Amitriptyline results in decreased expression of HPSE mRNA CTD PMID:22341215 NCBI chr 4:83,292,461...83,335,153
Ensembl chr 4:83,292,461...83,335,153
JBrowse link
G HS3ST2 heparan sulfate-glucosamine 3-sulfotransferase 2 decreases expression ISO Amitriptyline results in decreased expression of HS3ST2 mRNA CTD PMID:22341215 NCBI chr16:22,814,162...22,916,338
Ensembl chr16:22,814,162...22,916,338
JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A increases expression ISO Amitriptyline results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr 5:63,957,874...63,962,445
Ensembl chr 5:63,960,356...63,962,507
Ensembl chr 5:63,960,356...63,962,507
JBrowse link
G HTR1D 5-hydroxytryptamine receptor 1D decreases expression ISO Amitriptyline results in decreased expression of HTR1D mRNA CTD PMID:22341215 NCBI chr 1:23,191,895...23,217,502
Ensembl chr 1:23,191,895...23,194,729
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C affects binding EXP Amitriptyline binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL33 interleukin 33 affects expression ISO Amitriptyline affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 9:6,214,591...6,257,983
Ensembl chr 9:6,215,786...6,257,983
JBrowse link
G INHBE inhibin subunit beta E increases expression EXP Amitriptyline results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280
JBrowse link
G ITGB6 integrin subunit beta 6 decreases expression ISO Amitriptyline results in decreased expression of ITGB6 mRNA CTD PMID:22341215 NCBI chr 2:160,099,671...160,200,272
Ensembl chr 2:160,099,667...160,200,313
JBrowse link
G KCNA4 potassium voltage-gated channel subfamily A member 4 decreases expression ISO Amitriptyline results in decreased expression of KCNA4 mRNA CTD PMID:22341215 NCBI chr11:30,009,730...30,017,030
Ensembl chr11:30,009,730...30,017,030
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 PMID:21158687 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCNN2 potassium calcium-activated channel subfamily N member 2 decreases activity ISO Amitriptyline results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr 5:114,055,978...114,496,500
Ensembl chr 5:114,055,926...114,496,500
Ensembl chr 5:114,055,926...114,496,500
JBrowse link
G KCNS1 potassium voltage-gated channel modifier subfamily S member 1 decreases expression ISO Amitriptyline results in decreased expression of KCNS1 mRNA CTD PMID:22341215 NCBI chr20:45,091,214...45,101,127
Ensembl chr20:45,091,214...45,101,127
JBrowse link
G KCNS3 potassium voltage-gated channel modifier subfamily S member 3 decreases expression ISO Amitriptyline results in decreased expression of KCNS3 mRNA CTD PMID:22341215 NCBI chr 2:17,877,847...17,932,961
Ensembl chr 2:17,877,847...18,361,616
JBrowse link
G LOX lysyl oxidase affects expression ISO Amitriptyline affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr 5:122,063,195...122,078,259
Ensembl chr 5:122,063,195...122,078,360
JBrowse link
G LSS lanosterol synthase increases expression EXP Amitriptyline results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824
JBrowse link
G MACROH2A1 macroH2A.1 histone affects expression ISO Amitriptyline affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr 5:135,334,381...135,401,998
Ensembl chr 5:135,333,900...135,399,914
JBrowse link
G MANBA mannosidase beta affects expression ISO Amitriptyline affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 4:102,630,770...102,760,968
Ensembl chr 4:102,630,770...102,760,994
JBrowse link
G MAOA monoamine oxidase A affects expression ISO Amitriptyline affects the expression of MAOA mRNA CTD PMID:21820738 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MLX MAX dimerization protein MLX affects expression ISO Amitriptyline affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr17:42,567,100...42,573,203
Ensembl chr17:42,567,068...42,573,239
JBrowse link
G MMP16 matrix metallopeptidase 16 increases expression ISO Amitriptyline results in increased expression of MMP16 mRNA CTD PMID:22341215 NCBI chr 8:88,032,009...88,327,483
Ensembl chr 8:88,032,011...88,328,025
JBrowse link
G MRPS18B mitochondrial ribosomal protein S18B affects expression ISO Amitriptyline affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr 6:30,617,320...30,626,393
Ensembl chr 6:30,617,840...30,626,395
JBrowse link
G MSMO1 methylsterol monooxygenase 1 affects expression ISO Amitriptyline affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NMB neuromedin B decreases expression ISO Amitriptyline results in decreased expression of NMB mRNA CTD PMID:22341215 NCBI chr15:84,655,132...84,658,611
Ensembl chr15:84,655,129...84,658,563
JBrowse link
G NMUR1 neuromedin U receptor 1 decreases expression ISO Amitriptyline results in decreased expression of NMUR1 mRNA CTD PMID:21820738 NCBI chr 2:231,519,903...231,530,456
Ensembl chr 2:231,523,187...231,530,445
JBrowse link
G NOG noggin decreases expression ISO Amitriptyline results in decreased expression of NOG mRNA CTD PMID:22341215 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
JBrowse link
G NPHS2 NPHS2 stomatin family member, podocin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:23024785 NCBI chr 1:179,550,539...179,575,987
Ensembl chr 1:179,550,539...179,575,952
JBrowse link
G NPY neuropeptide Y increases expression ISO Amitriptyline results in increased expression of NPY mRNA CTD PMID:22341215 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
JBrowse link
G NPY5R neuropeptide Y receptor Y5 increases expression ISO Amitriptyline results in increased expression of NPY5R mRNA CTD PMID:21820738 NCBI chr 4:163,336,968...163,352,277
Ensembl chr 4:163,343,892...163,351,934
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases expression EXP Amitriptyline results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 affects response to substance ISO NR3C1 protein affects the susceptibility to Amitriptyline CTD PMID:11226678 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 increases expression ISO Amitriptyline results in increased expression of NR3C2 mRNA CTD PMID:12393271 NCBI chr 4:148,078,764...148,444,698
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G NREP neuronal regeneration related protein affects expression ISO Amitriptyline affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464
JBrowse link
G NTNG1 netrin G1 decreases expression ISO Amitriptyline results in decreased expression of NTNG1 mRNA CTD PMID:22341215 NCBI chr 1:107,140,017...107,484,923
Ensembl chr 1:107,140,007...107,483,458
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression EXP Amitriptyline results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G OAF out at first homolog affects expression ISO Amitriptyline affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334
JBrowse link
G PATJ PATJ crumbs cell polarity complex component decreases expression ISO Amitriptyline results in decreased expression of PATJ mRNA CTD PMID:22341215 NCBI chr 1:61,742,477...62,163,915
Ensembl chr 1:61,742,477...62,178,675
Ensembl chr 1:61,742,477...62,178,675
JBrowse link
G PC pyruvate carboxylase affects expression ISO Amitriptyline affects the expression of PC mRNA CTD PMID:18355885 NCBI chr11:66,848,420...66,958,418
Ensembl chr11:66,848,417...66,958,386
JBrowse link
G PECR peroxisomal trans-2-enoyl-CoA reductase affects expression ISO Amitriptyline affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 2:216,031,656...216,081,843
Ensembl chr 2:215,996,329...216,082,955
JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase increases expression EXP Amitriptyline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr10:13,277,799...13,300,064
Ensembl chr10:13,277,796...13,302,412
JBrowse link
G PLCD4 phospholipase C delta 4 decreases expression ISO Amitriptyline results in decreased expression of PLCD4 mRNA CTD PMID:22341215 NCBI chr 2:218,606,871...218,637,186
Ensembl chr 2:218,607,855...218,637,184
JBrowse link
G PLPP4 phospholipid phosphatase 4 decreases expression ISO Amitriptyline results in decreased expression of PLPP4 mRNA CTD PMID:22341215 NCBI chr10:120,456,954...120,600,123
Ensembl chr10:120,457,227...120,592,065
Ensembl chr10:120,457,227...120,592,065
JBrowse link
G POR cytochrome p450 oxidoreductase affects expression ISO Amitriptyline affects the expression of POR mRNA CTD PMID:18355885 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
JBrowse link
G PROKR1 prokineticin receptor 1 decreases expression ISO Amitriptyline results in decreased expression of PROKR1 mRNA CTD PMID:21820738 NCBI chr 2:68,643,579...68,658,251
Ensembl chr 2:68,643,589...68,658,247
Ensembl chr 2:68,643,589...68,658,247
JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein] CTD PMID:28633109 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
JBrowse link
G RASD1 ras related dexamethasone induced 1 increases expression ISO Amitriptyline results in increased expression of RASD1 mRNA CTD PMID:22341215 NCBI chr17:17,494,437...17,496,395
Ensembl chr17:17,494,437...17,496,395
JBrowse link
G RBL2 RB transcriptional corepressor like 2 affects expression ISO Amitriptyline affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648
JBrowse link
G REG3A regenerating family member 3 alpha increases expression ISO Amitriptyline results in increased expression of REG3B mRNA CTD PMID:22341215 NCBI chr 2:79,157,006...79,159,753
Ensembl chr 2:79,157,003...79,159,753
JBrowse link
G RNF112 ring finger protein 112 decreases expression ISO Amitriptyline results in decreased expression of RNF112 mRNA CTD PMID:22341215 NCBI chr17:19,406,979...19,417,276
Ensembl chr17:19,411,125...19,417,276
JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Amitriptyline results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 decreases expression ISO Amitriptyline results in decreased expression of SCN11A mRNA CTD PMID:22341215 NCBI chr 3:38,845,764...39,051,944
Ensembl chr 3:38,845,764...39,052,157
Ensembl chr 3:38,845,764...39,052,157
JBrowse link
G SEMA6A semaphorin 6A increases expression ISO Amitriptyline results in increased expression of SEMA6A mRNA CTD PMID:22341215 NCBI chr 5:116,443,555...116,574,823
Ensembl chr 5:116,443,555...116,574,823
Ensembl chr 5:116,443,555...116,574,823
JBrowse link
G SERPINA3 serpin family A member 3 increases expression EXP Amitriptyline results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr14:94,612,391...94,624,053
Ensembl chr14:94,612,384...94,624,055
Ensembl chr14:94,612,384...94,624,055
JBrowse link
G SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression ISO Amitriptyline affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr15:83,447,123...83,618,743
Ensembl chr15:83,447,228...83,618,743
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions
decreases activity
EXP Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
Amitriptyline results in decreased activity of SLC22A1 protein
CTD PMID:30189235 PMID:31364238 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions
decreases activity
EXP Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Amitriptyline results in decreased activity of SLC22A2 protein
CTD PMID:21599003 PMID:23770354 PMID:28629854 PMID:30189235 PMID:31364238 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC2A3 solute carrier family 2 member 3 decreases expression EXP Amitriptyline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] CTD PMID:28629854 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G SLC6A6 solute carrier family 6 member 6 affects expression ISO Amitriptyline affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 3:14,402,576...14,489,349
Ensembl chr 3:14,402,576...14,489,349
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 affects expression ISO Amitriptyline affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594
JBrowse link
G SMAGP small cell adhesion glycoprotein increases expression ISO Amitriptyline results in increased expression of SMAGP mRNA CTD PMID:22341215 NCBI chr12:51,244,558...51,270,415
Ensembl chr12:51,244,558...51,270,415
JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 decreases activity
increases response to substance
multiple interactions
EXP
ISO
Amitriptyline results in decreased activity of SMPD1 protein
SMPD1 protein results in increased susceptibility to Amitriptyline
[Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein
CTD PMID:23770692 NCBI chr11:6,390,474...6,394,998
Ensembl chr11:6,390,440...6,394,998
JBrowse link
G SOD1 superoxide dismutase 1 increases expression ISO Amitriptyline results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SORL1 sortilin related receptor 1 decreases expression ISO Amitriptyline results in decreased expression of SORL1 mRNA CTD PMID:22341215 NCBI chr11:121,452,314...121,633,763
Ensembl chr11:121,452,314...121,633,763
JBrowse link
G SOX11 SRY-box transcription factor 11 increases expression ISO Amitriptyline results in increased expression of SOX11 mRNA CTD PMID:22341215 NCBI chr 2:5,692,384...5,701,385
Ensembl chr 2:5,692,384...5,701,385
JBrowse link
G SPRR1A small proline rich protein 1A increases expression ISO Amitriptyline results in increased expression of SPRR1A mRNA CTD PMID:22341215 NCBI chr 1:152,984,081...152,985,814
Ensembl chr 1:152,985,231...152,985,500
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link
G SSTR1 somatostatin receptor 1 decreases expression ISO Amitriptyline results in decreased expression of SSTR1 mRNA CTD PMID:21820738 NCBI chr14:38,207,904...38,213,067
Ensembl chr14:38,207,904...38,213,067
JBrowse link
G ST13 ST13 Hsp70 interacting protein affects expression ISO Amitriptyline affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639
JBrowse link
G STAC2 SH3 and cysteine rich domain 2 increases expression ISO Amitriptyline results in increased expression of STAC2 mRNA CTD PMID:22341215 NCBI chr17:39,210,536...39,225,945
Ensembl chr17:39,210,541...39,225,945
JBrowse link
G STBD1 starch binding domain 1 affects expression ISO Amitriptyline affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr 4:76,306,733...76,311,130
Ensembl chr 4:76,306,026...76,311,599
JBrowse link
G STMN1 stathmin 1 affects expression ISO Amitriptyline affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
JBrowse link
G STMN4 stathmin 4 increases expression ISO Amitriptyline results in increased expression of STMN4 mRNA CTD PMID:22341215 NCBI chr 8:27,235,308...27,258,865
Ensembl chr 8:27,235,323...27,258,420
JBrowse link
G TAGLN transgelin decreases expression EXP Amitriptyline results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464
JBrowse link
G TEX261 testis expressed 261 affects expression ISO Amitriptyline affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 2:70,985,942...70,994,873
Ensembl chr 2:70,985,942...70,994,873
JBrowse link
G TGM1 transglutaminase 1 increases expression ISO Amitriptyline results in increased expression of TGM1 mRNA CTD PMID:22341215 NCBI chr14:24,249,114...24,263,177
Ensembl chr14:24,249,114...24,264,432
JBrowse link
G TIMM10B translocase of inner mitochondrial membrane 10B affects expression ISO Amitriptyline affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr11:6,481,501...6,484,681
Ensembl chr11:6,481,485...6,508,978
Ensembl chr11:6,481,485...6,508,978
JBrowse link
G TRH thyrotropin releasing hormone multiple interactions EXP Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 3:129,974,720...129,977,935
Ensembl chr 3:129,974,688...129,977,935
JBrowse link
G TSHB thyroid stimulating hormone subunit beta multiple interactions EXP Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 1:115,029,826...115,035,935
Ensembl chr 1:115,029,826...115,034,302
Ensembl chr 1:115,029,826...115,034,302
JBrowse link
G UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression ISO Amitriptyline affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr19:18,563,766...18,577,550
Ensembl chr19:18,571,730...18,577,550
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 affects expression ISO Amitriptyline affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus affects expression ISO Amitriptyline affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr 4:69,588,417...69,653,247
Ensembl chr 4:69,588,417...69,653,249
JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 affects expression ISO Amitriptyline affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,184...68,568,527
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein] CTD PMID:23024785 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G WIPI1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Amitriptyline results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr17:68,421,281...68,457,496
Ensembl chr17:68,420,948...68,457,513
JBrowse link
cyclobenzaprine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP cyclobenzaprine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
nortriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
increases transport
EXP
ISO
ABCB1 exon SNP affects the susceptibility to Nortriptyline
ABCB1A protein results in increased transport of Nortriptyline; ABCB1A protein results in increased transport of Nortriptyline metabolite
CTD PMID:10700657 PMID:12082591 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 decreases activity EXP Nortriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G CASP3 caspase 3 decreases activity
increases activity
multiple interactions
ISO
EXP
Nortriptyline results in decreased activity of CASP3 protein
Nortriptyline results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein]
CTD PMID:17686041 PMID:18174477 PMID:22700542 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 multiple interactions
increases activity
EXP Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
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G CYCS cytochrome c, somatic decreases secretion ISO Nortriptyline results in decreased secretion of CYCS protein CTD PMID:17686041 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
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G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases metabolic processing EXP Nortriptyline results in increased metabolism of CYP1A2 protein CTD PMID:18359012 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity
multiple interactions
EXP Nortriptyline results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]
CTD PMID:15304522 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases response to substance
increases metabolic processing
multiple interactions
increases hydroxylation
EXP CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline
Nortriptyline results in increased metabolism of CYP2D6 protein
Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline]
CYP2D6 protein results in increased hydroxylation of Nortriptyline
CTD PMID:11673748 PMID:17470523 PMID:18359012 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases metabolic processing EXP Nortriptyline results in increased metabolism of CYP3A4 protein CTD PMID:18359012 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 increases metabolic processing EXP Nortriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G GNB3 G protein subunit beta 3 decreases response to substance
increases response to substance
EXP GNB3 gene polymorphism results in decreased susceptibility to Nortriptyline
GNB3 protein results in increased susceptibility to Nortriptyline
CTD PMID:14604448 NCBI chr12:6,840,922...6,847,393
Ensembl chr12:6,839,954...6,847,393
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C decreases expression EXP Nortriptyline results in decreased expression of HTR2C protein CTD PMID:8131152 NCBI chr  X:114,584,086...114,910,061
Ensembl chr  X:114,584,078...114,910,061
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Nortriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G PF4 platelet factor 4 affects expression EXP Nortriptyline affects the expression of PF4 protein CTD PMID:10770450 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027
JBrowse link
G PPBP pro-platelet basic protein affects expression EXP Nortriptyline affects the expression of PPBP protein CTD PMID:10770450 NCBI chr 4:73,986,439...73,988,190
Ensembl chr 4:73,986,439...73,988,190
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Nortriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC6A2 solute carrier family 6 member 2 affects response to substance EXP SLC6A2 gene polymorphism affects the susceptibility to Nortriptyline CTD PMID:17018806 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,604...55,706,192
JBrowse link
G SLC6A4 solute carrier family 6 member 4 affects response to substance
increases response to substance
decreases response to substance
EXP SLC6A4 polymorphism affects the susceptibility to Nortriptyline; SLC6A4 promoter polymorphism affects the susceptibility to Nortriptyline
SLC6A4 protein results in increased susceptibility to Nortriptyline
SLC6A4 gene polymorphism results in decreased susceptibility to Nortriptyline
CTD PMID:14604448 PMID:17018806 PMID:21658141 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Nortriptyline CTD PMID:19362101 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
protriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 decreases activity EXP Protriptyline results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G SLC6A2 solute carrier family 6 member 2 decreases expression ISO Protriptyline results in decreased expression of SLC6A2 protein CTD PMID:18923402 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,604...55,706,192
JBrowse link

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  CHEBI ontology 24370
    role 24278
      biological role 24245
        aetiopathogenetic role 23033
          carcinogenic agent 21725
            polycyclic arene 19635
              ortho-fused polycyclic arene 10165
                dibenzannulene 182
                  1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole + 0
                  dibenzo[a,d][7]annulene + 182
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  CHEBI ontology 24370
    subatomic particle 24327
      composite particle 24327
        hadron 24327
          baryon 24327
            nucleon 24327
              atomic nucleus 24327
                atom 24327
                  main group element atom 24173
                    main group molecular entity 24173
                      s-block molecular entity 23426
                        hydrogen molecular entity 23253
                          hydrides 21895
                            organic hydride 21363
                              organic fundamental parent 21363
                                hydrocarbon 21029
                                  cyclic hydrocarbon 19947
                                    arene 19944
                                      polycyclic arene 19635
                                        ortho-fused polycyclic arene 10165
                                          dibenzannulene 182
                                            1-(2,4-dichloro-10,11-dihydrodibenzo[a,d][7]annulen-5-yl)imidazole + 0
                                            dibenzo[a,d][7]annulene + 182
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