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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.17.3.2 (xanthine oxidase) inhibitor
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Accession:CHEBI:35634 term browser browse the term
Definition:An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2).
Synonyms:related_synonym: EC 1.17.3.2 (xanthine oxidase) inhibitors;   EC 1.17.3.2 inhibitor;   EC 1.17.3.2 inhibitors;   Schardinger enzyme inhibitor;   Schardinger enzyme inhibitors;   hypoxanthine oxidase inhibitor;   hypoxanthine oxidase inhibitors;   hypoxanthine-xanthine oxidase inhibitor;   hypoxanthine-xanthine oxidase inhibitors;   hypoxanthine:oxygen oxidoreductase inhibitor;   hypoxanthine:oxygen oxidoreductase inhibitors;   xanthine oxidase inhibitor;   xanthine oxidase inhibitors;   xanthine oxidoreductase inhibitor;   xanthine oxidoreductase inhibitors;   xanthine:O2 oxidoreductase inhibitor;   xanthine:O2 oxidoreductase inhibitors;   xanthine:oxygen oxidoreductase inhibitor;   xanthine:oxygen oxidoreductase inhibitors;   xanthine:xanthine oxidase inhibitor;   xanthine:xanthine oxidase inhibitors

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6-formylpterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist decreases expression ISO 2-amino-4-hydroxy-6-formylpteridine results in decreased expression of BID protein CTD PMID:16019850 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Casp3 caspase 3 increases activity ISO 2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP3 protein CTD PMID:16019850 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity ISO 2-amino-4-hydroxy-6-formylpteridine results in increased activity of CASP8 protein CTD PMID:16019850 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 2-amino-4-hydroxy-6-formylpteridine affects the localization of CYCS protein CTD PMID:16019850 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Prkcd protein kinase C, delta affects localization ISO 2-amino-4-hydroxy-6-formylpteridine affects the localization of PRKCD protein CTD PMID:16019850 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
allopurinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]] CTD PMID:21912612 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]] CTD PMID:21912612 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Agt angiotensinogen multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722 PMID:19145780 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Allopurinol results in increased expression of ALDH1A1 mRNA CTD PMID:28138970 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Allopurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Allopurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein modified form]; Allopurinol inhibits the reaction [Fructose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of CASP1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 protein]		 CTD PMID:22426011 PMID:23647015 PMID:24491314 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Cat catalase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in decreased activity of CAT protein] CTD PMID:12566098 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO
EXP		 Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]; Allopurinol inhibits the reaction [Fructose results in increased secretion of CCL2 protein]; pyrazolanthrone inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of CCL2 mRNA]
Allopurinol inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]		 CTD PMID:15689417 PMID:19158351 PMID:26641773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145 		JBrowse link
G Cd36 CD36 molecule increases expression EXP Allopurinol results in increased expression of CD36 mRNA CTD PMID:28138970 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in decreased expression of CDH1 protein] CTD PMID:22648416 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Ckm creatine kinase, M-type decreases secretion EXP Allopurinol results in decreased secretion of CKM protein CTD PMID:21912612 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of CXCL10 mRNA] CTD PMID:18322232 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Allopurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN protein]		 CTD PMID:23647015 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Allopurinol inhibits the reaction [nickel chloride results in increased expression of FN1 protein] CTD PMID:22648416 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Allopurinol results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of GLUL protein] CTD PMID:24491314 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions EXP Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein] CTD PMID:20084674 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in decreased activity of GSR protein] CTD PMID:12566098 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Allopurinol inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Allopurinol inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]
Allopurinol results in increased expression of HMOX1 mRNA		 CTD PMID:20888885 PMID:22659318 PMID:25091725 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased expression of IFNB1 mRNA] CTD PMID:18322232 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein] CTD PMID:28949055 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of IKBKB protein] CTD PMID:24491314 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of IL18 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:22426011 PMID:23647015 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO
EXP		 Allopurinol results in decreased expression of IL1B mRNA
Allopurinol inhibits the reaction [Fructose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of IL1B protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]		 CTD PMID:7695923 PMID:22426011 PMID:23647015 PMID:24491314 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]
Allopurinol inhibits the reaction [Fructose results in increased expression of IL6 protein]; Allopurinol inhibits the reaction [sodium arsenite results in increased expression of IL6 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]		 CTD PMID:15689417 PMID:21912612 PMID:22426011 PMID:23867654 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Insr insulin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein] CTD PMID:22426011 PMID:24491314 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein] CTD PMID:22426011 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Lep leptin multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein] CTD PMID:22426011 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lgals9 galectin 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of LGALS9 protein] CTD PMID:19605544 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO Allopurinol results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:26641773 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Allopurinol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK14 protein] CTD PMID:15650392 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO Allopurinol results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [Allopurinol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:26641773 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Allopurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Allopurinol inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:12566098 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Lipopolysaccharides promotes the reaction [NFAT5 protein binds to IL6 promoter]]; Allopurinol inhibits the reaction [Lipopolysaccharides results in increased expression of NFAT5 mRNA]
Allopurinol inhibits the reaction [Oxonic Acid affects the localization of NFAT5 protein]		 CTD PMID:23867654 PMID:30651350 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of NFKBIA protein] CTD PMID:24491314 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of NLRP3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]		 CTD PMID:22426011 PMID:23647015 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP Allopurinol inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NOS3 protein]] CTD PMID:21912612 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP
ISO		 Allopurinol inhibits the reaction [Glucose results in increased expression of NR1H3 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of NR1H3 protein] CTD PMID:23647015 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA protein]		 CTD PMID:22426011 PMID:23647015 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Allopurinol inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:17244722 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP
ISO		 Allopurinol inhibits the reaction [Fructose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of PYCARD protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of PYCARD protein] CTD PMID:22426011 PMID:23647015 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO		 Allopurinol inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]		 CTD PMID:24491314 PMID:28949055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:21909718 PMID:22865646 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]; Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A5 protein]		 CTD PMID:21909718 PMID:22426011 PMID:22865646 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]
Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Allopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]		 CTD PMID:19605544 PMID:21909718 PMID:22865646 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases transport
increases uptake		 ISO SLC22A7 protein results in increased transport of Allopurinol
SLC22A7 protein results in increased uptake of Allopurinol		 CTD PMID:12065749 PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Allopurinol CTD PMID:15100168 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions EXP Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Allopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP] CTD PMID:19605544 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702 		JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions ISO Allopurinol inhibits the reaction [Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of SLC5A3 mRNA]] CTD PMID:23867654 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]		 CTD PMID:23647015 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]
Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF2 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of SREBF2 protein]		 CTD PMID:23647015 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Allopurinol inhibits the reaction [vanadium pentoxide results in increased phosphorylation of STAT1 protein] CTD PMID:18322232 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of STAT3 protein]] CTD PMID:21912612 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects activity EXP Allopurinol affects the activity of TDO2 protein CTD PMID:7306070 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940 		JBrowse link
G Tnf tumor necrosis factor increases chemical synthesis
increases expression
multiple interactions		 ISO
EXP		 TNF protein results in increased chemical synthesis of Allopurinol
Allopurinol results in increased expression of TNF mRNA
Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of TNF mRNA]
Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein]		 CTD PMID:7695923 PMID:22426011 PMID:26641773 PMID:28949055 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO
EXP		 Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]
Allopurinol inhibits the reaction [Fructose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of TXNIP protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of TXNIP protein]		 CTD PMID:23647015 PMID:24491314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
G Umod uromodulin multiple interactions ISO Allopurinol inhibits the reaction [potassium oxonate affects the expression of UMOD protein]; Allopurinol inhibits the reaction [potassium oxonate results in increased expression of UMOD mRNA] CTD PMID:21909718 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity
multiple interactions
affects activity		 ISO
EXP		 Allopurinol results in decreased activity of XDH protein
Allopurinol inhibits the reaction [[Streptozocin affects the activity of XDH protein] which results in increased chemical synthesis of Hydrogen Peroxide]; Allopurinol inhibits the reaction [Indomethacin results in increased activity of XDH protein]; Allopurinol inhibits the reaction [Streptozocin affects the activity of XDH protein]; Allopurinol inhibits the reaction [XDH protein results in increased oxidation of Quinoxalines]
Allopurinol affects the activity of XDH protein
Allopurinol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of XDH protein]		 CTD PMID:1447108 PMID:3677084 PMID:8891675 PMID:12115777 PMID:12566098 PMID:12694877 PMID:12826072 PMID:14982945 PMID:17439425 PMID:19933411 PMID:20142047 PMID:21939274 PMID:23647015 PMID:26968635 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
alloxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression EXP Oxypurinol results in increased expression of ALPL mRNA CTD PMID:26968635 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression EXP Oxypurinol results in increased expression of BGLAP mRNA CTD PMID:26968635 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA] CTD PMID:28949055 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Oxypurinol results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA] CTD PMID:28949055 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Oxypurinol results in increased expression of CXCL10 mRNA CTD PMID:25091725 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Dek DEK proto-oncogene increases secretion ISO DEK protein results in increased secretion of Oxypurinol CTD PMID:28558019 NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Oxypurinol results in decreased expression of ENPP1 mRNA CTD PMID:26968635 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Oxypurinol results in increased expression of HMOX1 mRNA CTD PMID:25091725 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Oxypurinol inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein] CTD PMID:28949055 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions
increases uptake		 ISO Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] CTD PMID:16135657 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Oxypurinol results in increased expression of TNF mRNA
Oxypurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Oxypurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]		 CTD PMID:26641773 PMID:28949055 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity EXP Oxypurinol results in decreased activity of XDH protein CTD PMID:26968635 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
aspalathin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; aspalathin inhibits the reaction [Glucose results in increased expression of CCL2 protein] CTD PMID:25338943 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G F10 coagulation factor X multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein]; aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein] CTD PMID:25325928 NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716 		JBrowse link
G F2 coagulation factor II multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G F5 coagulation factor V multiple interactions ISO aspalathin inhibits the reaction [[F5 protein co-treated with F10 protein co-treated with Calcium Chloride] results in increased metabolism of F2 protein] CTD PMID:25325928 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534 		JBrowse link
G F7 coagulation factor VII multiple interactions ISO aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein] CTD PMID:25325928 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of ICAM1 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of ICAM1 protein] CTD PMID:25338943 PMID:25655391 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:25655391 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] CTD PMID:25655391 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] CTD PMID:25655391 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:25655391 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO aspalathin inhibits the reaction [Glucose affects the localization of RELA protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:25338943 PMID:25655391 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sele selectin E multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of SELE protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SELE protein] CTD PMID:25338943 PMID:25655391 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO aspalathin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] CTD PMID:25325928 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TLR4 protein] CTD PMID:25655391 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO aspalathin inhibits the reaction [[TNF protein co-treated with F7 protein] results in increased expression of F10 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; aspalathin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] CTD PMID:25325928 PMID:25655391 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO aspalathin inhibits the reaction [Glucose results in increased expression of VCAM1 protein]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 mRNA]; aspalathin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein] CTD PMID:25338943 PMID:25655391 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
febuxostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in decreased secretion of AGER protein modified form]; Febuxostat inhibits the reaction [Paraquat results in increased expression of AGER mRNA] CTD PMID:30726711 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:26036690 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:26036690 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein] CTD PMID:26036690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Febuxostat results in increased expression of CCL2 mRNA CTD PMID:26641773 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of CTNNB1 protein] CTD PMID:30726711 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 mRNA]; Febuxostat inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant] results in decreased expression of GOT2 protein] CTD PMID:29107957 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of HMGB1 mRNA] CTD PMID:30726711 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of IKBKB protein] CTD PMID:26036690 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of MMP9 protein] CTD PMID:30726711 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:26036690 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of PTGS2 mRNA] CTD PMID:30726711 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in increased expression of RELA protein] CTD PMID:26036690 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Febuxostat inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein] CTD PMID:26036690 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Febuxostat inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
Febuxostat results in increased expression of TNF mRNA		 CTD PMID:26036690 PMID:26641773 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Febuxostat inhibits the reaction [Paraquat results in increased expression of VEGFA protein] CTD PMID:30726711 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
pedalitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pedalitin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO pedalitin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO pedalitin results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
purpurogallin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        biochemical role 19370
          enzyme inhibitor 18240
            EC 1.* (oxidoreductase) inhibitor 16562
              EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor 530
                EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor 97
                  EC 1.17.3.2 (xanthine oxidase) inhibitor 97
                    6-formylpterin 5
                    8-azaadenine + 0
                    allopurinol + 68
                    alloxanthine + 15
                    aspalathin 16
                    febuxostat 16
                    pedalitin 3
                    procyanidin C1 0
                    purpurogallin 1
paths to the root