Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.5.2.6 (beta-lactamase) inhibitor
go back to main search page
Accession:CHEBI:35625 term browser browse the term
Definition:An EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor that interferes with the action of beta-lactamase (EC 3.5.2.6).
Synonyms:related_synonym: EC 3.5.2.6 (beta-lactamase) inhibitors;   EC 3.5.2.6 inhibitor;   EC 3.5.2.6 inhibitors;   ampicillinase inhibitor;   ampicillinase inhibitors;   beta-lactam hydrolase inhibitor;   beta-lactam hydrolase inhibitors;   beta-lactamase A, B, C inhibitor;   beta-lactamase A, B, C inhibitors;   beta-lactamase AME I inhibitor;   beta-lactamase AME I inhibitors;   beta-lactamase I-III inhibitor;   beta-lactamase I-III inhibitors;   beta-lactamase inhibitor;   beta-lactamase inhibitors;   cephalosporin-beta-lactamase inhibitor;   cephalosporin-beta-lactamase inhibitors;   cephalosporinase inhibitor;   cephalosporinase inhibitors;   exopenicillinase inhibitor;   exopenicillinase inhibitors;   neutrapen inhibitor;   neutrapen inhibitors;   penicillin amido-beta-lactamhydrolase inhibitor;   penicillin amido-beta-lactamhydrolase inhibitors;   penicillin beta-lactamase inhibitor;   penicillin beta-lactamase inhibitors;   penicillinase I, II inhibitor;   penicillinase I, II inhibitors;   penicillinase inhibitor;   penicillinase inhibitors



show annotations for term's descendants           Sort by:
 
ceftriaxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 decreases expression EXP Ceftriaxone results in decreased expression of ACE2 mRNA CTD PMID:29745864 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Actb actin, beta increases expression EXP Ceftriaxone results in increased expression of ACTB mRNA CTD PMID:29745864 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Bace1 beta-secretase 1 decreases expression EXP Ceftriaxone results in decreased expression of BACE1 mRNA CTD PMID:29745864 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO
EXP
Ceftriaxone results in decreased expression of CAT protein
Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]]
CTD PMID:19442074 PMID:25053526 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Ceftriaxone results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP Ceftriaxone results in increased expression of ECE1 mRNA CTD PMID:29745864 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Epo erythropoietin increases expression EXP Ceftriaxone results in increased expression of EPO mRNA CTD PMID:29745864 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Ide insulin degrading enzyme increases expression EXP Ceftriaxone results in increased expression of IDE mRNA CTD PMID:29745864 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]] CTD PMID:25053526 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mme membrane metallo-endopeptidase increases expression EXP Ceftriaxone results in increased expression of MME mRNA CTD PMID:29745864 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
EXP Ceftriaxone inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC1A2 protein]; Ceftriaxone inhibits the reaction [JZL195 results in decreased expression of and affects the folding of SLC1A2 protein]; Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]
Ceftriaxone results in increased expression of SLC1A2 protein
CTD PMID:19625514 PMID:19717140 PMID:28257918 PMID:29045497 PMID:29432698 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP Ceftriaxone inhibits the reaction [Cocaine results in decreased expression of SLC7A11 protein] CTD PMID:19717140 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]] CTD PMID:25053526 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
clavulanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin increases expression
decreases expression
ISO Clavulanic Acid results in increased expression of EREG mRNA
Clavulanic Acid results in decreased expression of EREG mRNA
CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Clavulanic Acid results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Clavulanic Acid results in increased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 increases expression
decreases expression
ISO Clavulanic Acid results in increased expression of IL24 mRNA
Clavulanic Acid results in decreased expression of IL24 mRNA
CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Clavulanic Acid results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression
increases expression
ISO Clavulanic Acid results in decreased expression of SLC7A11 mRNA
Clavulanic Acid results in increased expression of SLC7A11 mRNA
CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Clavulanic Acid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Clavulanic Acid results in increased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
salsalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 affects expression EXP salicylsalicylic acid affects the expression of IL6 protein CTD PMID:20876710 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP salicylsalicylic acid affects the expression of and affects the phosphorylation of NOS3 protein CTD PMID:20876710 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects expression EXP salicylsalicylic acid affects the expression of RELA protein CTD PMID:20876710 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod2 superoxide dismutase 2 affects expression EXP salicylsalicylic acid affects the expression of SOD2 protein CTD PMID:20876710 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Vegfa vascular endothelial growth factor A affects expression EXP salicylsalicylic acid affects the expression of VEGFA protein CTD PMID:20876710 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
tazobactam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions EXP Ozone promotes the reaction [[tazobactam co-treated with Piperacillin] results in increased expression of IL1B mRNA] CTD PMID:16369182 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ozone promotes the reaction [[tazobactam co-treated with Piperacillin] results in increased expression of TNF mRNA] CTD PMID:16369182 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biochemical role 19390
          enzyme inhibitor 18395
            EC 3.* (hydrolase) inhibitor 17930
              EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 17806
                EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor 24
                  EC 3.5.2.6 (beta-lactamase) inhibitor 24
                    3-carboxyphenyl phenylacetamidomethylphosphonate 0
                    7,8-dihydroxy-1-methoxy-3-methyl-10-oxo-1H,10H-pyrano[4,3-b]chromene-9-carboxylic acid 0
                    7,8-dihydroxy-1-methoxy-3-methyl-10-oxo-4,10-dihydro-1H,3H-pyrano[4,3-b]chromene-9-carboxylic acid 0
                    7,8-dihydroxy-3-methyl-10-oxo-10H-chromeno[3,2-c]pyridine-9-carboxylic acid 0
                    avibactam 0
                    avibactam sodium + 0
                    ceftriaxone 13
                    clavulanic acid 8
                    potassium clavulanate + 0
                    salsalate 5
                    tazobactam 2
                    tazobactam sodium + 0
paths to the root