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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:29191726 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
anethole results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:21212515 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:29191726 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Esr1 |
estrogen receptor 1 |
affects binding multiple interactions |
ISO EXP |
anethole metabolite binds to ESR1 protein anethole analog binds to ESR1 protein anethole metabolite inhibits the reaction [Estradiol binds to ESR1 protein] |
CTD |
PMID:12818366 PMID:27420082 |
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NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
decreases activity |
EXP |
anethole analog results in decreased activity of GGT1 protein |
CTD |
PMID:20171274 |
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NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
anethole results in increased expression of GSTA2 protein |
CTD |
PMID:8406240 |
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NCBI chr 8:85,640,081...85,645,621
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
decreases activity |
ISO |
anethole results in decreased activity of IKBKB protein |
CTD |
PMID:10871845 |
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NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] |
CTD |
PMID:16531003 |
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NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] |
CTD |
PMID:10871845 |
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NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
anethole results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:21212515 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
anethole results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:21212515 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein] |
CTD |
PMID:10871845 |
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NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases activity decreases expression |
ISO |
anethole results in decreased activity of MMP2 protein anethole results in decreased expression of MMP2 mRNA |
CTD |
PMID:21212515 |
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NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity decreases expression |
ISO |
anethole results in decreased activity of MMP9 protein anethole results in decreased expression of MMP9 mRNA |
CTD |
PMID:21212515 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:10871845 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases degradation |
ISO |
anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] anethole results in decreased degradation of NFKBIA protein |
CTD |
PMID:10871845 PMID:21212515 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] |
CTD |
PMID:10871845 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Plau |
plasminogen activator, urokinase |
decreases expression |
ISO |
anethole results in decreased expression of PLAU mRNA |
CTD |
PMID:21212515 |
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NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:10871845 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
anethole results in increased expression of TIMP1 mRNA |
CTD |
PMID:21212515 |
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NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein]; anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:10871845 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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