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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:29191726 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
anethole results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:21212515 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:29191726 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Esr1 |
estrogen receptor 1 |
affects binding multiple interactions |
ISO EXP |
anethole metabolite binds to ESR1 protein anethole analog binds to ESR1 protein anethole metabolite inhibits the reaction [Estradiol binds to ESR1 protein] |
CTD |
PMID:12818366 PMID:27420082 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
decreases activity |
EXP |
anethole analog results in decreased activity of GGT1 protein |
CTD |
PMID:20171274 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression |
EXP |
anethole results in increased expression of GSTA2 protein |
CTD |
PMID:8406240 |
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NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
decreases activity |
ISO |
anethole results in decreased activity of IKBKB protein |
CTD |
PMID:10871845 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; anethole inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] |
CTD |
PMID:16531003 |
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NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein] |
CTD |
PMID:10871845 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
anethole results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:21212515 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
anethole results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:21212515 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein] |
CTD |
PMID:10871845 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases activity decreases expression |
ISO |
anethole results in decreased activity of MMP2 protein anethole results in decreased expression of MMP2 mRNA |
CTD |
PMID:21212515 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases activity decreases expression |
ISO |
anethole results in decreased activity of MMP9 protein anethole results in decreased expression of MMP9 mRNA |
CTD |
PMID:21212515 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:10871845 |
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases degradation |
ISO |
anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] anethole results in decreased degradation of NFKBIA protein |
CTD |
PMID:10871845 PMID:21212515 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein] |
CTD |
PMID:10871845 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Plau |
plasminogen activator, urokinase |
decreases expression |
ISO |
anethole results in decreased expression of PLAU mRNA |
CTD |
PMID:21212515 |
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NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
anethole inhibits the reaction [Ceramides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] |
CTD |
PMID:10871845 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
anethole results in increased expression of TIMP1 mRNA |
CTD |
PMID:21212515 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
anethole inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; anethole inhibits the reaction [TNF protein results in increased activity of MAP2K1 protein]; anethole inhibits the reaction [TNF protein results in increased activity of MAPK8 protein]; anethole inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; anethole inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anethole inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:10871845 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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