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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cetirizine
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Accession:CHEBI:3561 term browser browse the term
Definition:A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
Synonyms:exact_synonym: (2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
 related_synonym: Cetirizin;   Formula=C21H25ClN2O3;   InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26);   InChIKey=ZKLPARSLTMPFCP-UHFFFAOYSA-N;   SMILES=OC(=O)COCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1;   cetirizina;   cetirizinum
 xref: CAS:83881-51-0;   DrugBank:DB00341;   Drug_Central:581;   HMDB:HMDB0005032;   KEGG:C07778;   KEGG:D07662;   LINCS:LSM-1544
 xref_mesh: MESH:D017332
 xref: PMID:15850951;   PMID:20455340;   PMID:8103703;   Reaxys:7227333;   Wikipedia:Cetirizine


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cetirizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Cetirizine results in decreased expression of ABCB11 mRNA CTD PMID:24852568 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of Cetirizine CTD PMID:12584158 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases activity ISO Cetirizine analog results in decreased activity of ALOX5 protein CTD PMID:15482930 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Apoe apolipoprotein E multiple interactions
decreases expression
ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CCL23 protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CXCL1 protein; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA; [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA; APOE gene mutant form inhibits the reaction [Cetirizine results in decreased expression of MLXIPL mRNA]; APOE protein results in decreased susceptibility to [Dietary Fats co-treated with Cetirizine]
Cetirizine results in decreased expression of APOE mRNA
CTD PMID:24852568 PMID:25020133 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CCL23 protein CTD PMID:25020133 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CKM protein CTD PMID:25020133 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in decreased expression of CXCL1 protein CTD PMID:25020133 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Cetirizine analog results in decreased activity of CYP3A4 protein; Cetirizine results in decreased activity of CYP3A4 protein CTD PMID:15482930 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Hexb hexosaminidase subunit beta affects secretion EXP Cetirizine affects the secretion of HEXB protein CTD PMID:7655991 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding
ISO Cetirizine binds to and results in decreased activity of HRH1 protein
Cetirizine analog binds to HRH1 protein; Cetirizine binds to HRH1 protein
CTD PMID:15482930 PMID:16401869 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Il4 interleukin 4 decreases expression ISO Cetirizine results in decreased expression of IL4 protein CTD PMID:19672097 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [montelukast co-treated with Cetirizine] results in decreased expression of IL5 protein CTD PMID:15061398 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Mlxipl MLX interacting protein-like decreases expression
multiple interactions
ISO Cetirizine results in decreased expression of MLXIPL mRNA
APOE gene mutant form inhibits the reaction [Cetirizine results in decreased expression of MLXIPL mRNA]
CTD PMID:24852568 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS2 mRNA CTD PMID:25020133 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [Cetirizine co-treated with Dietary Fats co-treated with APOE gene mutant form] results in increased expression of NOS3 mRNA CTD PMID:25020133 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link

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  CHEBI ontology 19771
    role 19716
      biological role 19716
        xenobiotic 18392
          cetirizine 15
Path 2
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  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      carboxylic acid 18157
                                        monocarboxylic acid 17530
                                          cetirizine 15
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