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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:9H-purine
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Accession:CHEBI:35589 term browser browse the term
Definition:The 9H-tautomer of purine.
Synonyms:related_synonym: Formula=C5H4N4;   InChI=1S/C5H4N4/c1-4-5(8-2-6-1)9-3-7-4/h1-3H,(H,6,7,8,9);   InChIKey=KDCGOANMDULRCW-UHFFFAOYSA-N;   SMILES=c1ncc2nc[nH]c2n1
 xref: Beilstein:606899;   CAS:120-73-0;   Gmelin:3120;   Wikipedia:Purine
 cyclic_relationship: is_tautomer_of CHEBI:17258;   is_tautomer_of CHEBI:35586;   is_tautomer_of CHEBI:35588

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3',5'-cyclic GMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE5A phosphodiesterase 5A increases degradation EXP PDE5 protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,947 		JBrowse link
G PDE6C phosphodiesterase 6C increases degradation EXP PDE6C protein results in increased degradation of Cyclic GMP CTD PMID:18669600 NCBI chr14:105,010,974...105,122,628
Ensembl chr14:105,011,922...105,037,498
Ensembl chr14:105,011,922...105,037,498 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 increases activity EXP Cyclic GMP results in increased activity of PRKG1 protein CTD PMID:18037907 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,560,785...98,793,318 		JBrowse link
3-methyladenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA] CTD PMID:28803810 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144 		JBrowse link
G BECN1 beclin 1 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein] CTD PMID:28803810 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:28803810 PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] CTD PMID:28803810 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA] CTD PMID:28803810 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein] CTD PMID:28803810 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256 		JBrowse link
adenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions		 EXP Adenosine results in decreased phosphorylation of MYL9 protein
8-phenyltheophylline inhibits the reaction [Adenosine results in decreased phosphorylation of MYL9 protein]		 CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296 		JBrowse link
ATP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression		 EXP tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of BCL2 protein] CTD PMID:17997382 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions		 EXP Adenosine Triphosphate results in increased activity of CASP8 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]		 CTD PMID:17997382 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470 		JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions		 EXP Adenosine Triphosphate affects the localization of CYCS protein
[Calcium co-treated with Phosphates co-treated with Adenosine Triphosphate] affects the localization of CYCS protein; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate affects the localization of CYCS protein]		 CTD PMID:16489745 PMID:17997382 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G MYL9 myosin light chain 9 decreases phosphorylation
multiple interactions		 EXP Adenosine Triphosphate results in decreased phosphorylation of MYL9 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]		 CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296 		JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions		 EXP Adenosine Triphosphate results in increased expression of TNF protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of TNF protein]		 CTD PMID:17997382 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655 		JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity
multiple interactions		 EXP Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form
Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]		 CTD PMID:11278295 NCBI chr 6:47,339,759...47,458,457 JBrowse link
hypoxanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein] CTD PMID:21984542 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G XDH xanthine dehydrogenase multiple interactions EXP [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Hydrogen Peroxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Superoxides; CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein]; tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein] CTD PMID:21984542 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,986,528...108,080,151 		JBrowse link
sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP sinefungin results in decreased activity of COMT protein CTD PMID:26577531 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 875
    role 855
      biological role 855
        biochemical role 726
          metabolite 714
            fundamental metabolite 92
              purine 17
                9H-purine 17
                  (S)-1-\{1-[1-(2-amino-9H-purin-6-yl)piperidin-4-yl]-1H-1,2,3-triazol-4-yl\}ethanol 0
                  adenine + 13
                  guanine + 4
                  purmorphamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 875
    subatomic particle 860
      composite particle 860
        hadron 860
          baryon 860
            nucleon 860
              atomic nucleus 860
                atom 860
                  main group element atom 850
                    p-block element atom 847
                      carbon group element atom 823
                        carbon atom 822
                          organic molecular entity 822
                            organic molecule 735
                              organic cyclic compound 645
                                organic heterocyclic compound 361
                                  organic heteropolycyclic compound 252
                                    organic heterobicyclic compound 100
                                      imidazopyrimidine 23
                                        purines 23
                                          purine 17
                                            9H-purine 17
                                              (S)-1-\{1-[1-(2-amino-9H-purin-6-yl)piperidin-4-yl]-1H-1,2,3-triazol-4-yl\}ethanol 0
                                              adenine + 13
                                              guanine + 4
                                              purmorphamine 0
paths to the root