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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indole
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Accession:CHEBI:35581 term browser browse the term
Definition:Either of two isomeric forms comprising a benzene ring fused to a pyrrole ring.
Synonyms:related_synonym: Formula=C8H7N
 xref: HMDB:HMDB0000738;   PMID:24563545;   PMID:24695245;   Wikipedia:Indole


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1H-indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO indole binds to and results in increased activity of AHR protein; indole results in increased activity of [AHR protein binds to ARNT protein] CTD PMID:9407059 PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO indole results in increased activity of [AHR protein binds to ARNT protein] CTD PMID:9407059 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Epo erythropoietin multiple interactions EXP indole inhibits the reaction [cobaltous chloride results in increased expression of EPO mRNA]; indole inhibits the reaction [cobaltous chloride results in increased expression of EPO protein] CTD PMID:21863063 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Mc1r melanocortin 1 receptor affects binding ISO indole analog binds to MC1R protein CTD PMID:11909711 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mc3r melanocortin 3 receptor affects binding ISO indole analog binds to MC3R protein CTD PMID:11909711 NCBI chr 3:170,252,901...170,253,998
Ensembl chr 3:170,252,901...170,253,998
JBrowse link
G Mc4r melanocortin 4 receptor affects binding ISO indole analog binds to MC4R protein CTD PMID:11909711 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Mc5r melanocortin 5 receptor affects binding ISO indole analog binds to MC5R protein CTD PMID:11909711 NCBI chr18:64,113,659...64,118,700
Ensembl chr18:64,114,933...64,116,524
JBrowse link
2-methyl-1H-indole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO 2-methylindole results in increased expression of ABCB1 mRNA CTD PMID:32092453 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO 2-methylindole results in increased expression of CYP1A1 protein
2-methylindole inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CTD PMID:31201936 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO 2-methylindole results in increased expression of CYP1A2 protein CTD PMID:31201936 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions
ISO 2-methylindole results in increased expression of CYP3A4 mRNA
NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA]
CTD PMID:32092453 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects binding
multiple interactions
increases expression
ISO 2-methylindole binds to NR1I2 protein
NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA]
2-methylindole results in increased expression of NR1I2 mRNA
CTD PMID:32092453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        mancude ring 8130
          organic mancude parent 8130
            mancude organic heterocyclic parent 8130
              mancude organic heterobicyclic parent 5212
                indole 12
                  1H-indole + 12
                  3H-indole + 0
                  indolyl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17979
                                    organic heterobicyclic compound 16780
                                      benzopyrrole 9542
                                        indoles 9214
                                          indole 12
                                            1H-indole + 12
                                            3H-indole + 0
                                            indolyl group + 0
paths to the root