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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-oxide
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Accession:CHEBI:35580 term browser browse the term
Synonyms:related_synonym: N-oxides


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4-nitroquinoline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
multiple interactions
ISO ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog
Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]
CTD PMID:15766272 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of ABL1 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of ABL1 mRNA
CTD PMID:22561872 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL1 mRNA CTD PMID:22561872 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL6 mRNA CTD PMID:22561872 NCBI chr10:39,654,771...39,717,592
Ensembl chr10:39,655,455...39,719,312
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BCL2A1B mRNA CTD PMID:22561872 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BUB1 mRNA CTD PMID:22561872 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL2 mRNA CTD PMID:22561872 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL3 mRNA CTD PMID:22561872 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL4 mRNA CTD PMID:22561872 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL5 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of CCL5 mRNA
CTD PMID:22561872 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL7 mRNA CTD PMID:22561872 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNA2 mRNA CTD PMID:22561872 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNB1 mRNA CTD PMID:22561872 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]
4-Nitroquinoline-1-oxide results in increased expression of CCND1 mRNA
CTD PMID:20043093 PMID:27148699 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne2 cyclin E2 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNE2 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CCNE2 mRNA
CTD PMID:22561872 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cd59 CD59 molecule multiple interactions EXP [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 PMID:20202993 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
JBrowse link
G Cdc25c cell division cycle 25C decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDC25C mRNA
4-Nitroquinoline-1-oxide results in increased expression of CDC25C mRNA
CTD PMID:22561872 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdc7 cell division cycle 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CDC7 mRNA CTD PMID:22561872 NCBI chr14:3,826,658...3,846,891
Ensembl chr14:3,826,659...3,846,891
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDKN1B mRNA CTD PMID:22561872 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CPT1B mRNA CTD PMID:22561872 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein CTD PMID:19840781 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cryz crystallin zeta increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein
ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein]
CTD PMID:12566915 NCBI chr 2:260,884,315...260,911,827
Ensembl chr 2:260,884,337...260,911,792
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CSF2 mRNA CTD PMID:22561872 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctsd cathepsin D increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CTSD protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CTSD protein]
CTD PMID:23499697 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cttn cortactin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CTTN mRNA; 4-Nitroquinoline-1-oxide results in increased expression of CTTN protein CTD PMID:27148699 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CXCL10 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CXCL10 mRNA
CTD PMID:22561872 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL11 mRNA CTD PMID:22561872 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL2 mRNA CTD PMID:22561872 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL1 mRNA CTD PMID:22561872 PMID:27148699 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL5 mRNA CTD PMID:27148699 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL9 mRNA CTD PMID:22561872 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCR3 mRNA CTD PMID:22561872 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Cyb5a cytochrome b5 type A increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein]
CTD PMID:23499697 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of E2F3 mRNA CTD PMID:22561872 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of EPCAM mRNA CTD PMID:27148699 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 4-Nitroquinoline-1-oxide results in increased mutagenesis of HPRT1 gene CTD PMID:26362870 PMID:28454271 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA] CTD PMID:20043093 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein CTD PMID:19840781 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IFNB1 mRNA CTD PMID:22561872 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IFNG mRNA
4-Nitroquinoline-1-oxide results in increased expression of IFNG mRNA
CTD PMID:22561872 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL10 mRNA CTD PMID:22561872 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL12A mRNA CTD PMID:22561872 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL12B mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL12B mRNA
CTD PMID:22561872 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il19 interleukin 19 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL19 mRNA CTD PMID:22561872 NCBI chr13:47,663,592...47,677,869
Ensembl chr13:47,664,080...47,670,407
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
4-Nitroquinoline-1-oxide results in increased expression of IL1B mRNA
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of IL1B protein]
CTD PMID:22561872 PMID:28397014 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL23A mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL23A mRNA
CTD PMID:22561872 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il24 interleukin 24 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL24 mRNA CTD PMID:22561872 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il6 interleukin 6 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL6 mRNA CTD PMID:22561872 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 multiple interactions
increases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of and results in increased phosphorylation of MAPK6 protein
4-Nitroquinoline-1-oxide results in increased expression of MAPK6 mRNA
CTD PMID:22561872 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP10 mRNA CTD PMID:22561872 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP12 mRNA
4-Nitroquinoline-1-oxide results in increased expression of MMP12 mRNA
CTD PMID:22561872 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP13 mRNA CTD PMID:22561872 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP3 mRNA CTD PMID:22561872 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP9 mRNA CTD PMID:22561872 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
EXP ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein]; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein] CTD PMID:12566915 PMID:28397014 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction
decreases activity
multiple interactions
decreases response to substance
ISO
EXP
NQO1 protein results in increased reduction of 4-Nitroquinoline-1-oxide
4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein]
NQO1 protein results in decreased susceptibility to 4-Nitroquinoline-1-oxide
CTD PMID:9310146 PMID:23499697 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Osm oncostatin M increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSM mRNA CTD PMID:22561872 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Osmr oncostatin M receptor increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSMR mRNA CTD PMID:22561872 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis
EXP
ISO
4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA; 4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene
CTD PMID:19965957 PMID:20202993 PMID:22923490 PMID:29362862 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
increases activity
EXP geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of POR protein] CTD PMID:23499697 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppbp pro-platelet basic protein increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of PPBP mRNA
4-Nitroquinoline-1-oxide results in decreased expression of PPBP mRNA
CTD PMID:22561872 NCBI chr14:18,852,433...18,853,237
Ensembl chr14:18,851,954...18,853,315
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases response to substance
ISO
EXP
[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein]
PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide
Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide]
4-Nitroquinoline-1-oxide results in increased expression of PTGS2 mRNA; 4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein
CTD PMID:20043093 PMID:20857495 PMID:22561872 PMID:28397014 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of PTHLH mRNA CTD PMID:27148699 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO
EXP
4-Nitroquinoline-1-oxide affects the localization of RELA protein
4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein]
CTD PMID:22561872 PMID:28397014 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of RRM2 mRNA CTD PMID:22561872 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO 4-Nitroquinoline-1-oxide results in increased mutagenesis of TK1 gene CTD PMID:28454271 NCBI chr10:106,817,556...106,828,888
Ensembl chr10:106,817,601...106,828,884
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of TNF protein] CTD PMID:28397014 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TNFAIP3 mRNA CTD PMID:22561872 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of TNFSF11 mRNA CTD PMID:22561872 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 affects response to substance
decreases expression
ISO
EXP
TRP53 protein affects the susceptibility to 4-Nitroquinoline-1-oxide
4-Nitroquinoline-1-oxide results in decreased expression of TP53 protein
CTD PMID:16543248 PMID:20599846 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TRAF1 mRNA CTD PMID:22561872 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of WEE1 mRNA CTD PMID:22561872 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of XCL1 mRNA CTD PMID:22561872 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
JBrowse link
5,5-dimethyl-1-pyrroline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide] CTD PMID:20199096 PMID:28754375 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
Ammothamnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP oxymatrine inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein] CTD PMID:27713174 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of CREBBP mRNA] CTD PMID:18395914 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] CTD PMID:23568217 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:15603720 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP oxymatrine promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein] CTD PMID:27713174 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IFNG protein] CTD PMID:15603720 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 protein] CTD PMID:15603720 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA] CTD PMID:23568217 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2 protein] CTD PMID:15603720 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:23568217 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
increases expression
ISO oxymatrine inhibits the reaction [arsenic trioxide results in decreased localization of KCNH2 protein]
oxymatrine results in increased expression of KCNH2 protein
CTD PMID:23103450 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP oxymatrine promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein] CTD PMID:27713174 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:23568217 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:18395914 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad7 SMAD family member 7 increases expression ISO oxymatrine results in increased expression of SMAD7 mRNA CTD PMID:18395914 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:18395914 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633229 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:15603720 PMID:23568217 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
chlordiazepoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Chlordiazepoxide results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Chlordiazepoxide CTD PMID:11691872 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
minoxidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ren renin affects expression
multiple interactions
increases activity
increases expression
ISO
EXP
Minoxidil affects the expression of REN protein
Minoxidil binds to and results in decreased activity of REN protein
Minoxidil results in increased activity of REN protein
Minoxidil results in increased expression of REN protein
CTD PMID:28811 PMID:145319 PMID:790007 PMID:8238566 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Minoxidil CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
pyridine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO pyridine N-oxide results in increased expression of CYP1A1 mRNA CTD PMID:12147272 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP pyridine N-oxide results in increased expression of CYP2E1 protein CTD PMID:1379807 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
SCH-351591 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy1a amylase, alpha 1A increases expression EXP SCH 351591 results in increased expression of AMY1A mRNA CTD PMID:20585143 NCBI chr 2:216,428,709...216,443,518
Ensembl chr 2:216,428,709...216,443,518
JBrowse link
G Ctrl chymotrypsin-like increases expression EXP SCH 351591 results in increased expression of CTRL mRNA CTD PMID:20585143 NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP SCH 351591 results in increased expression of CXCL1 protein CTD PMID:20585143 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP SCH 351591 results in increased expression of DBP mRNA CTD PMID:20585143 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP SCH 351591 results in increased expression of NR1D1 mRNA CTD PMID:20585143 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP SCH 351591 results in increased expression of NR1D2 mRNA CTD PMID:20585143 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Per1 period circadian regulator 1 increases expression EXP SCH 351591 results in increased expression of PER1 mRNA CTD PMID:20585143 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Prss1 serine protease 1 increases expression EXP SCH 351591 results in increased expression of PRSS1 mRNA CTD PMID:20585143 NCBI chr 4:70,776,046...70,779,249
Ensembl chr 4:70,776,046...70,779,249
JBrowse link
tirapazamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tirapazamine results in increased expression of CDKN1A CTD PMID:15814660 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CYP2E1 protein results in increased reduction of and results in increased activity of and results in increased susceptibility to tirapazamine; Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; tempol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Tp53 tumor protein p53 increases expression
increases response to substance
ISO tirapazamine results in increased expression of TP53
TRP53 protein mutant form results in increased susceptibility to tirapazamine
TP53 results in increased susceptibility to tirapazamine
CTD PMID:15814660 PMID:16012721 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions
increases reduction
ISO [MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine] CTD PMID:29856598 NCBI chr13:102,693,679...102,724,120
Ensembl chr13:102,698,546...102,721,218
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      group 19755
        polyatomic entity 19754
          heteroatomic molecular entity 19681
            oxide 11633
              N-oxide 114
                1-NO-cAMP 0
                IC202A 0
                adenosine 1-oxide 0
                chlordiazepoxide + 4
                morpholine N-oxide + 0
                nitrone + 3
                pyrazine N-oxide + 0
                pyridine N-oxides + 10
                pyrimidine N-oxide + 2
                quinoline N-oxide + 75
                ranitidine N-oxide 0
                tertiary amine oxide + 25
                tirapazamine 6
                triazoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      p-block molecular entity 19732
                        chalcogen molecular entity 19425
                          oxygen molecular entity 19387
                            oxide 11633
                              N-oxide 114
                                1-NO-cAMP 0
                                IC202A 0
                                adenosine 1-oxide 0
                                chlordiazepoxide + 4
                                morpholine N-oxide + 0
                                nitrone + 3
                                pyrazine N-oxide + 0
                                pyridine N-oxides + 10
                                pyrimidine N-oxide + 2
                                quinoline N-oxide + 75
                                ranitidine N-oxide 0
                                tertiary amine oxide + 25
                                tirapazamine 6
                                triazoxide 0
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