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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-oxide
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Accession:CHEBI:35580 term browser browse the term
Synonyms:related_synonym: N-oxides



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4-nitroquinoline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects export
multiple interactions
ISO ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog
Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]
CTD PMID:15766272 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of ABL1 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of ABL1 mRNA
CTD PMID:22561872 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL1 mRNA CTD PMID:22561872 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of ACSL6 mRNA CTD PMID:22561872 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BCL2A1B mRNA CTD PMID:22561872 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BSCL2 mRNA CTD PMID:22003191 NCBI chr 1:205,731,814...205,743,430
Ensembl chr 1:205,733,872...205,743,421
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of BUB1 mRNA CTD PMID:22561872 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL2 mRNA CTD PMID:22561872 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL3 mRNA CTD PMID:22561872 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL4 mRNA CTD PMID:22561872 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL5 mRNA
4-Nitroquinoline-1-oxide results in decreased expression of CCL5 mRNA
CTD PMID:22561872 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CCL7 mRNA CTD PMID:22561872 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNA2 mRNA CTD PMID:22561872 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNB1 mRNA CTD PMID:22561872 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]
4-Nitroquinoline-1-oxide results in increased expression of CCND1 mRNA
CTD PMID:20043093 PMID:27148699 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne2 cyclin E2 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CCNE2 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CCNE2 mRNA
CTD PMID:22561872 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
JBrowse link
G Cd59b CD59b molecule multiple interactions EXP [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein CTD PMID:19965957 PMID:20202993 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cdc25c cell division cycle 25C decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDC25C mRNA
4-Nitroquinoline-1-oxide results in increased expression of CDC25C mRNA
CTD PMID:22561872 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdc7 cell division cycle 7 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CDC7 mRNA CTD PMID:22561872 NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CDKN1B mRNA CTD PMID:22561872 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of CPT1B mRNA CTD PMID:22561872 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of CRYAB protein CTD PMID:19840781 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Cryz crystallin zeta increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein
ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CRYZ protein]
CTD PMID:12566915 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CSF2 mRNA CTD PMID:22561872 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctsd cathepsin D multiple interactions
increases activity
EXP geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CTSD protein] CTD PMID:23499697 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cttn cortactin increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CTTN mRNA; 4-Nitroquinoline-1-oxide results in increased expression of CTTN protein CTD PMID:27148699 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of CXCL10 mRNA
4-Nitroquinoline-1-oxide results in increased expression of CXCL10 mRNA
CTD PMID:22561872 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL11 mRNA CTD PMID:22561872 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL2 mRNA CTD PMID:22561872 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL1 mRNA CTD PMID:22561872 PMID:27148699 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL5 mRNA CTD PMID:27148699 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCL9 mRNA CTD PMID:22561872 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of CXCR3 mRNA CTD PMID:22561872 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cyb5a cytochrome b5 type A increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of CYB5A protein]
CTD PMID:23499697 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of E2F3 mRNA CTD PMID:22561872 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of EPCAM mRNA CTD PMID:27148699 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO Glucose inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of GPX2 protein] CTD PMID:32942007 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression
multiple interactions
ISO 4-Nitroquinoline-1-oxide results in increased expression of GPX4 protein
4-Nitroquinoline-1-oxide promotes the reaction [Glucose results in increased expression of GPX4 protein]
CTD PMID:32942007 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
ISO 4-Nitroquinoline-1-oxide results in increased expression of H2AX protein
4-Nitroquinoline-1-oxide results in increased phosphorylation of H2AX protein
CTD PMID:32087850 PMID:34510228 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 affects expression
multiple interactions
ISO 4-Nitroquinoline-1-oxide affects the expression of HMOX1 protein
4-Nitroquinoline-1-oxide inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; [4-Nitroquinoline-1-oxide results in increased susceptibility to Glucose] which results in increased expression of HMOX1 protein; Glucose inhibits the reaction [4-Nitroquinoline-1-oxide affects the expression of HMOX1 protein]
CTD PMID:32942007 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases mutagenesis ISO 4-Nitroquinoline-1-oxide results in increased mutagenesis of HPRT1 gene CTD PMID:26362870 PMID:28454271 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA; [4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of CCND1 mRNA]; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA] CTD PMID:20043093 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO [4-Nitroquinoline-1-oxide co-treated with Arecoline] results in increased expression of HSPB1 protein CTD PMID:19840781 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Ifnb1 interferon beta 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IFNB1 mRNA CTD PMID:22561872 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of IFNG mRNA
4-Nitroquinoline-1-oxide results in decreased expression of IFNG mRNA
CTD PMID:22561872 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL10 mRNA CTD PMID:22561872 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL12A mRNA CTD PMID:22561872 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL12B mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL12B mRNA
CTD PMID:22561872 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il19 interleukin 19 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL19 mRNA CTD PMID:22561872 NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO
EXP
4-Nitroquinoline-1-oxide results in increased expression of IL1B mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL1B protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of IL1B protein]
CTD PMID:22561872 PMID:28397014 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of IL23A mRNA
4-Nitroquinoline-1-oxide results in increased expression of IL23A mRNA
CTD PMID:22561872 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il24 interleukin 24 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL24 mRNA CTD PMID:22561872 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il6 interleukin 6 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of IL6 mRNA CTD PMID:22561872 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 multiple interactions
increases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of and results in increased phosphorylation of MAPK6 protein
4-Nitroquinoline-1-oxide results in increased expression of MAPK6 mRNA
CTD PMID:22561872 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP10 mRNA CTD PMID:22561872 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression
increases expression
ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP12 mRNA
4-Nitroquinoline-1-oxide results in increased expression of MMP12 mRNA
CTD PMID:22561872 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of MMP13 mRNA CTD PMID:22561872 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP3 mRNA CTD PMID:22561872 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of MMP9 mRNA CTD PMID:22561872 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein
ethyl-3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein]; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of NOS2 protein]
CTD PMID:12566915 PMID:28397014 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases reduction
decreases activity
multiple interactions
decreases response to substance
ISO
EXP
NQO1 protein results in increased reduction of 4-Nitroquinoline-1-oxide
4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in decreased activity of NQO1 protein]
NQO1 protein results in decreased susceptibility to 4-Nitroquinoline-1-oxide
CTD PMID:9310146 PMID:23499697 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Osm oncostatin M increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSM mRNA CTD PMID:22561872 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G Osmr oncostatin M receptor increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of OSMR mRNA CTD PMID:22561872 NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions
increases mutagenesis
EXP
ISO
4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 protein
4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA; 4-Nitroquinoline-1-oxide results in increased mutagenesis of PIGA gene
CTD PMID:19965957 PMID:20202993 PMID:22923490 PMID:29362862 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804
JBrowse link
G Por cytochrome p450 oxidoreductase increases activity
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased activity of POR protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased activity of POR protein]
CTD PMID:23499697 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Ppbp pro-platelet basic protein increases expression
decreases expression
ISO 4-Nitroquinoline-1-oxide results in increased expression of PPBP mRNA
4-Nitroquinoline-1-oxide results in decreased expression of PPBP mRNA
CTD PMID:22561872 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases response to substance
ISO
EXP
[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA; nimesulide inhibits the reaction [[4-Nitroquinoline-1-oxide co-treated with HRAS] results in increased expression of PTGS2 mRNA]
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein]
PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide
Zinc deficiency inhibits the reaction [PTGS2 gene mutant form results in decreased susceptibility to 4-Nitroquinoline-1-oxide]
4-Nitroquinoline-1-oxide results in increased expression of PTGS2 mRNA; 4-Nitroquinoline-1-oxide results in increased expression of PTGS2 protein
CTD PMID:20043093 PMID:20857495 PMID:22561872 PMID:28397014 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of PTHLH mRNA CTD PMID:27148699 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
ISO
EXP
4-Nitroquinoline-1-oxide affects the localization of RELA protein
4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein; geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of and affects the localization of RELA protein]
CTD PMID:22561872 PMID:28397014 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of RRM2 mRNA CTD PMID:22561872 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of SRXN1 mRNA CTD PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tk1 thymidine kinase 1 increases mutagenesis ISO 4-Nitroquinoline-1-oxide results in increased mutagenesis of TK1 gene CTD PMID:28454271 PMID:32087850 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP 4-Nitroquinoline-1-oxide results in increased expression of TNF protein
geraniol inhibits the reaction [4-Nitroquinoline-1-oxide results in increased expression of TNF protein]
CTD PMID:28397014 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TNFAIP3 mRNA CTD PMID:22561872 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of TNFSF11 mRNA CTD PMID:22561872 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tp53 tumor protein p53 affects response to substance
increases expression
decreases expression
ISO
EXP
TRP53 protein affects the susceptibility to 4-Nitroquinoline-1-oxide
4-Nitroquinoline-1-oxide results in increased expression of TP53 protein
4-Nitroquinoline-1-oxide results in decreased expression of TP53 protein
CTD PMID:16543248 PMID:20599846 PMID:32087850 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of TRAF1 mRNA CTD PMID:22561872 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression ISO 4-Nitroquinoline-1-oxide results in increased expression of WEE1 mRNA CTD PMID:22561872 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 decreases expression ISO 4-Nitroquinoline-1-oxide results in decreased expression of XCL1 mRNA CTD PMID:22561872 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
4-phenyl-3-furoxancarbonitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO 4-phenyl-3-furoxancarbonitrile results in increased expression of GCLC mRNA
4-phenyl-3-furoxancarbonitrile analog results in increased expression of GCLC mRNA
CTD PMID:22851183 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 4-phenyl-3-furoxancarbonitrile results in increased expression of GCLM mRNA CTD PMID:22851183 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-phenyl-3-furoxancarbonitrile results in increased expression of NQO1 mRNA CTD PMID:22851183 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
5,5-dimethyl-1-pyrroline N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline] which results in increased expression of MPO protein modified form; [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2,6-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 2-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-dichloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3,4-xylidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-anisidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 3-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-aminobenzonitrile; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-chloroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-ethylaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-fluoroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-nitroaniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of 4-toluidine; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Aminoglutethimide; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of aniline; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide] CTD PMID:20199096 PMID:28754375 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein CTD PMID:20348042 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
Ammothamnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO oxymatrine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]
oxymatrine inhibits the reaction [SNHG6 results in increased expression of ACTA2 protein]
CTD PMID:33241020 PMID:35785413 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions ISO oxymatrine inhibits the reaction [sodium arsenite results in decreased expression of ATP2A1 mRNA] CTD PMID:33241020 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions ISO [oxymatrine co-treated with sodium arsenite] results in decreased expression of ATP2A2 protein CTD PMID:33241020 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in decreased expression of BAX protein] CTD PMID:34459104 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of BCL2 protein] CTD PMID:34459104 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Capn2 calpain 2 increases expression
multiple interactions
ISO oxymatrine results in increased expression of CAPN2 protein
oxymatrine promotes the reaction [sodium arsenite results in increased expression of CAPN2 protein]
CTD PMID:33241020 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Cat catalase multiple interactions EXP oxymatrine inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein] CTD PMID:27713174 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of CCN2 protein] CTD PMID:35785413 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cldn2 claudin 2 multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 protein] CTD PMID:35290143 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of COL1A1 protein] CTD PMID:35785413 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of CREBBP mRNA] CTD PMID:18395914 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] CTD PMID:23568217 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
decreases expression
increases expression
ISO oxymatrine inhibits the reaction [sodium arsenite results in increased expression of DDIT3 protein]; oxymatrine promotes the reaction [sodium arsenite results in increased expression of DDIT3 mRNA]
oxymatrine results in decreased expression of DDIT3 protein
oxymatrine results in increased expression of DDIT3 mRNA
CTD PMID:33241020 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of FN1 protein] CTD PMID:35785413 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:15603720 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP oxymatrine promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein] CTD PMID:27713174 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
multiple interactions
ISO oxymatrine results in decreased expression of HSPA5 mRNA
oxymatrine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 mRNA]; oxymatrine inhibits the reaction [sodium arsenite results in increased expression of HSPA5 protein]
CTD PMID:33241020 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ifng interferon gamma multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IFNG protein] CTD PMID:15603720 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein] CTD PMID:15603720 PMID:35290143 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]
oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL1B protein]
CTD PMID:23568217 PMID:34459104 PMID:35290143 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in decreased expression of IL2 protein] CTD PMID:15603720 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
oxymatrine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]
oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
CTD PMID:23568217 PMID:34459104 PMID:35290143 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
increases expression
ISO oxymatrine inhibits the reaction [arsenic trioxide results in decreased localization of KCNH2 protein]
oxymatrine results in increased expression of KCNH2 protein
CTD PMID:23103450 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP1 protein] CTD PMID:34459104 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:34459104 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein] CTD PMID:35290143 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP oxymatrine promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein] CTD PMID:27713174 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of NOS2 protein] CTD PMID:34459104 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ocln occludin multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein] CTD PMID:35290143 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO oxymatrine analog inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:34459104 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
oxymatrine inhibits the reaction [Lipopolysaccharides promotes the reaction [RELA protein binds to CXCL2 promoter]]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
oxymatrine analog inhibits the reaction [TNF protein results in increased expression of RELA protein modified form]
CTD PMID:23568217 PMID:34459104 PMID:35290143 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions
increases expression
ISO oxymatrine promotes the reaction [sodium arsenite results in increased expression of RYR1 mRNA]
oxymatrine results in increased expression of RYR1 mRNA
CTD PMID:33241020 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G Smad2 SMAD family member 2 decreases expression ISO oxymatrine results in decreased expression of SMAD2 protein CTD PMID:35785413 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]
oxymatrine results in decreased expression of SMAD3 protein
CTD PMID:18395914 PMID:35785413 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad7 SMAD family member 7 increases expression ISO oxymatrine results in increased expression of SMAD7 mRNA CTD PMID:18395914 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
oxymatrine inhibits the reaction [sodium arsenite results in increased secretion of TGFB1 protein]
CTD PMID:18395914 PMID:33241020 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633229 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein] CTD PMID:35290143 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions EXP oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR9 protein] CTD PMID:35290143 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
oxymatrine analog inhibits the reaction [TNF protein results in decreased expression of BAX protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL1B protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of IL6 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP1 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; oxymatrine analog inhibits the reaction [TNF protein results in increased expression of RELA protein modified form]
oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; oxymatrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
CTD PMID:15603720 PMID:23568217 PMID:34459104 PMID:35290143 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vim vimentin multiple interactions ISO oxymatrine inhibits the reaction [SNHG6 results in increased expression of VIM protein] CTD PMID:35785413 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
chlordiazepoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Chlordiazepoxide results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon decreases response to substance EXP GABRE protein results in decreased susceptibility to Chlordiazepoxide CTD PMID:11691872 NCBI chr  X:150,060,035...150,078,773
Ensembl chr  X:150,060,040...150,078,693
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions EXP Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
JBrowse link
G Trhr thyrotropin releasing hormone receptor multiple interactions EXP Chlordiazepoxide inhibits the reaction [TRH protein modified form binds to TRHR protein] CTD PMID:2845442 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
JBrowse link
minoxidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin decreases expression ISO Minoxidil results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il24 interleukin 24 decreases expression ISO Minoxidil results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Minoxidil results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Ren renin affects expression
increases expression
increases activity
multiple interactions
ISO
EXP
Minoxidil affects the expression of REN protein
Minoxidil results in increased expression of REN protein
Minoxidil results in increased activity of REN protein
Minoxidil binds to and results in decreased activity of REN protein
CTD PMID:28811 PMID:145319 PMID:790007 PMID:8238566 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Minoxidil results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Minoxidil CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
pyridine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO pyridine N-oxide results in increased expression of CYP1A1 mRNA CTD PMID:12147272 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP pyridine N-oxide results in increased expression of CYP2E1 protein CTD PMID:1379807 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
SCH-351591 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy1 amylase alpha 1 increases expression EXP SCH 351591 results in increased expression of AMY1A mRNA CTD PMID:20585143 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816
JBrowse link
G Ctrl chymotrypsin-like increases expression EXP SCH 351591 results in increased expression of CTRL mRNA CTD PMID:20585143 NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP SCH 351591 results in increased expression of CXCL1 protein CTD PMID:20585143 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP SCH 351591 results in increased expression of DBP mRNA CTD PMID:20585143 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP SCH 351591 results in increased expression of NR1D1 mRNA CTD PMID:20585143 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP SCH 351591 results in increased expression of NR1D2 mRNA CTD PMID:20585143 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
JBrowse link
G Per1 period circadian regulator 1 increases expression EXP SCH 351591 results in increased expression of PER1 mRNA CTD PMID:20585143 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Prss1 serine protease 1 increases expression EXP SCH 351591 results in increased expression of PRSS1 mRNA CTD PMID:20585143 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792
JBrowse link
tirapazamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tirapazamine results in increased expression of CDKN1A CTD PMID:15814660 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP 1-phenylimidazole inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; caffeic acid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CAT protein inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; CYP2E1 protein results in increased reduction of and results in increased activity of and results in increased susceptibility to tirapazamine; Deferoxamine inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Dicumarol promotes the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Ethanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Quercetin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; tempol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO POR protein promotes the reaction [CYP2B6 protein results in increased susceptibility to tirapazamine] CTD PMID:10919648 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Tp53 tumor protein p53 increases expression
increases response to substance
ISO tirapazamine results in increased expression of TP53
TP53 results in increased susceptibility to tirapazamine
TRP53 protein mutant form results in increased susceptibility to tirapazamine
CTD PMID:15814660 PMID:16012721 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
trimethylamine N-oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein] CTD PMID:25568320 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Casp3 caspase 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased cleavage of CASP3 protein] CTD PMID:25568320 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO trimethyloxamine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 protein] CTD PMID:25568320 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Mbp myelin basic protein multiple interactions ISO trimethyloxamine promotes the reaction [MBP protein binds to MBP protein]; trimethyloxamine promotes the reaction [MBP protein mutant form binds to MBP protein mutant form] CTD PMID:12372316 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 increases reduction
multiple interactions
ISO MTARC1 protein results in increased reduction of trimethyloxamine
[MTARC1 protein results in increased reduction of trimethyloxamine] which results in increased chemical synthesis of trimethylamine; NAD affects the reaction [MTARC1 protein results in increased reduction of trimethyloxamine]
CTD PMID:29856598 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of trimethyloxamine CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions EXP trimethyloxamine promotes the reaction [rimabotulinumtoxinB results in increased cleavage of VAMP2 protein modified form] CTD PMID:27032463 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    chemical entity 19749
      group 19713
        polyatomic entity 19711
          heteroatomic molecular entity 19664
            oxide 12723
              N-oxide 141
                1,6-dimethoxyphenazine N(5),N(10)-dioxide 0
                1,6-dimethoxyphenazine N(5)-oxide 0
                1-NO-cAMP 0
                12-ketomethymycin N-oxide 0
                4-phenyl-3-furoxancarbonitrile 3
                DDAO 0
                IC202A 0
                adenosine 1-oxide 0
                chlordiazepoxide + 4
                didecylmethylamine oxide 0
                morpholine N-oxide + 0
                nitrone + 3
                pyrazine N-oxide + 0
                pyridine N-oxides + 10
                pyrimidine N-oxide + 6
                quinoline N-oxide + 79
                ranitidine N-oxide 0
                tertiary amine oxide + 47
                tirapazamine 6
                triazoxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    main group molecular entity 19698
                      p-block molecular entity 19698
                        chalcogen molecular entity 19492
                          oxygen molecular entity 19469
                            oxide 12723
                              N-oxide 141
                                1,6-dimethoxyphenazine N(5),N(10)-dioxide 0
                                1,6-dimethoxyphenazine N(5)-oxide 0
                                1-NO-cAMP 0
                                12-ketomethymycin N-oxide 0
                                4-phenyl-3-furoxancarbonitrile 3
                                DDAO 0
                                IC202A 0
                                adenosine 1-oxide 0
                                chlordiazepoxide + 4
                                didecylmethylamine oxide 0
                                morpholine N-oxide + 0
                                nitrone + 3
                                pyrazine N-oxide + 0
                                pyridine N-oxides + 10
                                pyrimidine N-oxide + 6
                                quinoline N-oxide + 79
                                ranitidine N-oxide 0
                                tertiary amine oxide + 47
                                tirapazamine 6
                                triazoxide 0
paths to the root