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ONTOLOGY REPORT - ANNOTATIONS


Term:cerivastatin
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Accession:CHEBI:3558 term browser browse the term
Definition:(3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
Synonyms:exact_synonym: (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid
 related_synonym: (3R,5S,6E)-7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-6-heptenoic acid;   (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoic acid;   (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoic acid;   Formula=C26H34FNO5;   InChI=1S/C26H34FNO5/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32)/b11-10+/t19-,20-/m1/s1;   InChIKey=SEERZIQQUAZTOL-ANMDKAQQSA-N;   SMILES=COCc1c(nc(C(C)C)c(\\C=C\\[C@@H](O)C[C@@H](O)CC(O)=O)c1-c1ccc(F)cc1)C(C)C;   cerivastatin acid
 alt_id: CHEBI:503465;   MESH:C086276
 xref: Beilstein:8366578 "Beilstein";   CAS:145599-86-6 "ChemIDplus";   CAS:145599-86-6 "KEGG COMPOUND";   DrugBank:DB00439;   Drug_Central:577 "DrugCentral";   KEGG:C07966;   KEGG:D07661
 xref_mesh: MESH:C086276
 xref: PMID:17560788 "ChEMBL";   PMID:18155906 "ChEMBL";   Wikipedia:Cerivastatin
 cyclic_relationship: is_conjugate_acid_of CHEBI:406059


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cerivastatin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:6480464
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 JBrowse link 1 259,692,020 259,818,922 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Itgal integrin subunit alpha L JBrowse link 1 198,744,053 198,781,745 RGD:6480464
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:6480464
G Mb myoglobin JBrowse link 7 118,101,633 118,108,864 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Rab4a RAB4A, member RAS oncogene family JBrowse link 19 56,585,598 56,613,078 RGD:6480464
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnni2 troponin I2, fast skeletal type JBrowse link 1 215,609,110 215,611,652 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    chemical entity 19714
      atom 19712
        nonmetal atom 19585
          nitrogen atom 18359
            nitrogen molecular entity 18359
              organonitrogen compound 18143
                organonitrogen heterocyclic compound 17034
                  pyridines 8327
                    cerivastatin 31
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        hydroxy carboxylic acid 3595
                                          hydroxy monocarboxylic acid 3595
                                            dihydroxy monocarboxylic acid 255
                                              cerivastatin 31
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.