mancude organic heterocyclic parent - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	mancude organic heterocyclic parent	go back to main search page
Accession:	CHEBI:35571	browse the term
Synonyms:	related_synonym:	mancude organic heterocyclic parents; mancude-ring organic heterocyclic parents

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Rat (11179) Mouse (11337) Human (11719) Chinchilla (0) Bonobo (0) Dog (7) Squirrel (0) Pig (35) Green Monkey (0) Naked Mole-rat (0) All
Genes (35)

1,10-phenanthroline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl aminopeptidase, membrane

multiple interactions
decreases activity

Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]

NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881

G

glutamyl aminopeptidase

multiple interactions

1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]

NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510

3',5'-cyclic GMP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phosphodiesterase 5A

increases degradation

PDE5 protein results in increased degradation of Cyclic GMP

NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,953

G

phosphodiesterase 6C

increases degradation

PDE6C protein results in increased degradation of Cyclic GMP

NCBI chr14:105,010,974...105,122,628
Ensembl chr14:105,050,691...105,122,421

G

protein kinase cGMP-dependent 1

increases activity

Cyclic GMP results in increased activity of PRKG1 protein

NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010

3-methyladenine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140

G

beclin 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]

PMID:28803810 PMID:34811946

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]

PMID:28803810 PMID:30287338

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

catalase

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cytochrome c, somatic

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

dynactin subunit 4

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]

NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

fission, mitochondrial 1

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]

NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955

G

glutathione peroxidase 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

lysosomal associated membrane protein 2

decreases expression

3-methyladenine results in decreased expression of LAMP2 protein

NCBI chr X:98,586,718...98,623,939
Ensembl chr X:98,556,710...98,623,940

G

microtubule associated protein 1 light chain 3 beta

multiple interactions
decreases lipidation

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Benzo(a)pyrene promotes the reaction [3-methyladenine results in decreased lipidation of MAP1LC3B protein]

PMID:34811946 PMID:36754226

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

marker of proliferation Ki-67

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]

NCBI chr14:137,266,622...137,296,312

G

MYD88 innate immune signal transduction adaptor

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

poly(ADP-ribose) polymerase 1

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]

PMID:30287338 PMID:34811946

NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196

G

superoxide dismutase 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

sequestosome 1

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]

PMID:28803810 PMID:34811946

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

translocase of outer mitochondrial membrane 20

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]

NCBI chr14:56,113,087...56,127,686
Ensembl chr14:56,113,192...56,127,677

G

tumor protein p53

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

5-methyl-pyrazole-3-carboxylic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

D-amino acid oxidase

decreases activity

5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein

NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633

adenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myosin light chain 9

decreases phosphorylation
multiple interactions

Adenosine results in decreased phosphorylation of MYL9 protein
8-phenyltheophylline inhibits the reaction [Adenosine results in decreased phosphorylation of MYL9 protein]

NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293

ATP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 apoptosis regulator

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of BCL2 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of BCL2 protein]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 8

increases activity
multiple interactions

Adenosine Triphosphate results in increased activity of CASP8 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

cytochrome c, somatic

affects localization
multiple interactions

Adenosine Triphosphate affects the localization of CYCS protein
[Calcium co-treated with Phosphates co-treated with Adenosine Triphosphate] affects the localization of CYCS protein; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate affects the localization of CYCS protein]

PMID:16489745 PMID:17997382

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

myosin light chain 9

decreases phosphorylation
multiple interactions

Adenosine Triphosphate results in decreased phosphorylation of MYL9 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]

NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293

G

tumor necrosis factor

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of TNF protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416

brimonidine tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions

Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]

NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728

caffeine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ryanodine receptor 1

increases activity
multiple interactions

Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form
Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]

NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458

hypoxanthine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

xanthine dehydrogenase

multiple interactions

[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Hydrogen Peroxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Superoxides; CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein]; tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein]

NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169

imipramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

flavin containing dimethylaniline monoxygenase 1

increases oxidation

FMO1 protein results in increased oxidation of Imipramine

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

sinefungin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

decreases activity

sinefungin results in decreased activity of COMT protein

NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998

zileuton

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase

decreases activity

zileuton results in decreased activity of ALOX5 protein

NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	5066
chemical entity	5066
molecular entity	5065
mancude ring	35
organic mancude parent	35
mancude organic heterocyclic parent	35
mancude organic heterobicyclic parent +	31
mancude organic heteromonocyclic parent +	1
mancude organic heterotricyclic parent +	3
Path 2
Term	Annotations
CHEBI ontology	5066
subatomic particle	5057
composite particle	5057
hadron	5057
baryon	5057
nucleon	5057
atomic nucleus	5057
atom	5057
main group element atom	5026
main group molecular entity	5025
s-block molecular entity	4957
hydrogen molecular entity	4950
hydrides	4555
organic hydride	4399
organic fundamental parent	4399
heterocyclic organic fundamental parent	4305
mancude organic heterocyclic parent	35
mancude organic heterobicyclic parent +	31
mancude organic heteromonocyclic parent +	1
mancude organic heterotricyclic parent +	3

paths to the root