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G |
ANPEP |
alanyl aminopeptidase, membrane |
multiple interactions decreases activity |
EXP |
Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] |
CTD |
PMID:17109655 |
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NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881
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G |
ENPEP |
glutamyl aminopeptidase |
multiple interactions |
EXP |
1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] |
CTD |
PMID:8141778 |
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NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
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G |
PDE5A |
phosphodiesterase 5A |
increases degradation |
EXP |
PDE5 protein results in increased degradation of Cyclic GMP |
CTD |
PMID:18669600 |
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NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,953
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G |
PDE6C |
phosphodiesterase 6C |
increases degradation |
EXP |
PDE6C protein results in increased degradation of Cyclic GMP |
CTD |
PMID:18669600 |
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NCBI chr14:105,010,974...105,122,628
Ensembl chr14:105,050,691...105,122,421
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G |
PRKG1 |
protein kinase cGMP-dependent 1 |
increases activity |
EXP |
Cyclic GMP results in increased activity of PRKG1 protein |
CTD |
PMID:18037907 |
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NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010
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G |
BAX |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA] |
CTD |
PMID:28803810 |
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NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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G |
BECN1 |
beclin 1 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein] |
CTD |
PMID:28803810 PMID:34811946 |
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NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
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G |
CASP3 |
caspase 3 |
multiple interactions |
EXP |
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] |
CTD |
PMID:28803810 PMID:30287338 |
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NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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G |
CASP8 |
caspase 8 |
multiple interactions |
EXP |
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] |
CTD |
PMID:28803810 |
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NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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G |
CAT |
catalase |
multiple interactions |
EXP |
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein] |
CTD |
PMID:34811946 |
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NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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G |
CYCS |
cytochrome c, somatic |
multiple interactions |
EXP |
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA] |
CTD |
PMID:28803810 |
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NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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G |
DCTN4 |
dynactin subunit 4 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA] |
CTD |
PMID:34811946 |
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NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746
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G |
FGD4 |
FYVE, RhoGEF and PH domain containing 4 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]] |
CTD |
PMID:34811946 |
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NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028
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G |
FIS1 |
fission, mitochondrial 1 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]] |
CTD |
PMID:34811946 |
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NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955
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G |
GPX1 |
glutathione peroxidase 1 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA] |
CTD |
PMID:34811946 |
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NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
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G |
LAMP2 |
lysosomal associated membrane protein 2 |
decreases expression |
EXP |
3-methyladenine results in decreased expression of LAMP2 protein |
CTD |
PMID:36754226 |
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NCBI chr X:98,586,718...98,623,939
Ensembl chr X:98,556,710...98,623,940
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G |
MAP1LC3B |
microtubule associated protein 1 light chain 3 beta |
multiple interactions decreases lipidation |
EXP |
3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Benzo(a)pyrene promotes the reaction [3-methyladenine results in decreased lipidation of MAP1LC3B protein] |
CTD |
PMID:34811946 PMID:36754226 |
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NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
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G |
MKI67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]] |
CTD |
PMID:34811946 |
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NCBI chr14:137,266,622...137,296,312
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G |
MYD88 |
MYD88 innate immune signal transduction adaptor |
multiple interactions |
EXP |
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]] |
CTD |
PMID:34811946 |
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NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109
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G |
OPA1 |
OPA1 mitochondrial dynamin like GTPase |
multiple interactions |
EXP |
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]] |
CTD |
PMID:34811946 |
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NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] |
CTD |
PMID:30287338 PMID:34811946 |
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NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
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G |
SOD1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA] |
CTD |
PMID:34811946 |
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NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
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G |
SQSTM1 |
sequestosome 1 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein] |
CTD |
PMID:28803810 PMID:34811946 |
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NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
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G |
TOMM20 |
translocase of outer mitochondrial membrane 20 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]] |
CTD |
PMID:34811946 |
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NCBI chr14:56,113,087...56,127,686
Ensembl chr14:56,113,192...56,127,677
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G |
TP53 |
tumor protein p53 |
multiple interactions |
EXP |
3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]] |
CTD |
PMID:34811946 |
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NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
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G |
DAO |
D-amino acid oxidase |
decreases activity |
EXP |
5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein |
CTD |
PMID:20952482 |
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NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633
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G |
MYL9 |
myosin light chain 9 |
decreases phosphorylation multiple interactions |
EXP |
Adenosine results in decreased phosphorylation of MYL9 protein 8-phenyltheophylline inhibits the reaction [Adenosine results in decreased phosphorylation of MYL9 protein] |
CTD |
PMID:10942722 |
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NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293
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G |
BCL2 |
BCL2 apoptosis regulator |
increases expression multiple interactions |
EXP |
Adenosine Triphosphate results in increased expression of BCL2 protein tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of BCL2 protein] |
CTD |
PMID:17997382 |
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NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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G |
CASP8 |
caspase 8 |
increases activity multiple interactions |
EXP |
Adenosine Triphosphate results in increased activity of CASP8 protein tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein] |
CTD |
PMID:17997382 |
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NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
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G |
CYCS |
cytochrome c, somatic |
affects localization multiple interactions |
EXP |
Adenosine Triphosphate affects the localization of CYCS protein [Calcium co-treated with Phosphates co-treated with Adenosine Triphosphate] affects the localization of CYCS protein; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate affects the localization of CYCS protein] |
CTD |
PMID:16489745 PMID:17997382 |
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NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
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G |
MYL9 |
myosin light chain 9 |
decreases phosphorylation multiple interactions |
EXP |
Adenosine Triphosphate results in decreased phosphorylation of MYL9 protein 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein] |
CTD |
PMID:10942722 |
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NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293
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G |
TNF |
tumor necrosis factor |
increases expression multiple interactions |
EXP |
Adenosine Triphosphate results in increased expression of TNF protein tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of TNF protein] |
CTD |
PMID:17997382 |
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NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
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G |
CREB1 |
cAMP responsive element binding protein 1 |
increases phosphorylation multiple interactions |
EXP |
Brimonidine Tartrate results in increased phosphorylation of CREB1 protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:17680988 |
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NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
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G |
RYR1 |
ryanodine receptor 1 |
increases activity multiple interactions |
EXP |
Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein] |
CTD |
PMID:11278295 |
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NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458
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G |
CAT |
catalase |
multiple interactions |
EXP |
CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein] |
CTD |
PMID:21984542 |
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NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
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G |
XDH |
xanthine dehydrogenase |
multiple interactions |
EXP |
[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Hydrogen Peroxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Superoxides; CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein]; tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein] |
CTD |
PMID:21984542 |
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NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169
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G |
FMO1 |
flavin containing dimethylaniline monoxygenase 1 |
increases oxidation |
EXP |
FMO1 protein results in increased oxidation of Imipramine |
CTD |
PMID:6439199 |
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NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
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G |
COMT |
catechol-O-methyltransferase |
decreases activity |
EXP |
sinefungin results in decreased activity of COMT protein |
CTD |
PMID:26577531 |
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NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
decreases activity |
EXP |
zileuton results in decreased activity of ALOX5 protein |
CTD |
PMID:11509739 |
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NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094
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