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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:alpha-adrenergic agonist
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Accession:CHEBI:35569 term browser browse the term
Definition:An agent that selectively binds to and activates alpha-adrenergic receptors.
Synonyms:related_synonym: alpha-adrenergic agonists;   alpha-adrenergic receptor agonist;   alpha-adrenoceptor agonists


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(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases export		 EXP [Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite
ABCC1 protein results in increased export of Epinephrine metabolite		 CTD PMID:19053318 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Aco2 aconitase 2 increases expression EXP Epinephrine results in increased expression of ACO2 protein CTD PMID:19464573 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Actn1 actinin, alpha 1 increases expression EXP Epinephrine results in increased expression of ACTN1 protein CTD PMID:19464573 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
decreases expression		 EXP Sildenafil Citrate inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein]; Tadalafil inhibits the reaction [Epinephrine results in decreased expression of ADIPOQ protein] CTD PMID:29233027 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
increases activity
affects binding		 EXP
ISO		 [Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; Epinephrine binds to and results in increased activity of ADRA1A protein
Epinephrine results in increased activity of ADRA1A protein
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1A protein; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
Epinephrine binds to ADRA1A protein		 CTD PMID:8183249 PMID:15306222 PMID:15672411 PMID:20030735 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
increases activity		 ISO [Epinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1B protein; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] CTD PMID:15306222 PMID:20030735 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
increases activity
multiple interactions		 ISO Epinephrine binds to ADRA1D protein
Epinephrine results in increased activity of ADRA1D protein
[Epinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1D protein; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]		 CTD PMID:8183249 PMID:15306222 PMID:20030735 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adra2a adrenoceptor alpha 2A increases activity
multiple interactions		 EXP
ISO		 Epinephrine results in increased activity of ADRA2A protein
Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein]
[Epinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2A protein; Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]		 CTD PMID:17341653 PMID:17680988 PMID:20030735 PMID:30737458 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2B protein; Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:17680988 PMID:20030735 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2C protein; Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan] CTD PMID:17680988 PMID:20030735 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP		 [CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine
Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB1 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]		 CTD PMID:8096834 PMID:12010770 PMID:14730417 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects response to substance
increases activity		 ISO
EXP		 [Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Epinephrine binds to and results in increased activity of ADRB2 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein; ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]
[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine
ADRB2 affects the susceptibility to Epinephrine		 CTD PMID:1389726 PMID:11164953 PMID:12920204 PMID:14722251 PMID:14730417 More... NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP
ISO		 Epinephrine binds to and results in increased activity of ADRB3 protein
[Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB3 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]		 CTD PMID:1682311 PMID:7815362 PMID:14730417 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Ak2 adenylate kinase 2 decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of AK2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein		 CTD PMID:19464573 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein CTD PMID:32305330 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions
increases activity		 EXP Cycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840 		JBrowse link
G Aqp7 aquaporin 7 affects localization
multiple interactions
increases expression		 ISO Epinephrine affects the localization of AQP7 protein
INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]		 CTD PMID:10777495 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP Epinephrine results in increased expression of ATP5F1A protein CTD PMID:19464573 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Epinephrine results in increased expression of BCL2 protein CTD PMID:36423730 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression ISO Epinephrine results in decreased expression of BMP2 mRNA; Epinephrine results in decreased expression of BMP2 protein CTD PMID:31520687 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G C1qbp complement C1q binding protein multiple interactions
increases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein
Epinephrine results in increased expression of C1QBP protein		 CTD PMID:19464573 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases abundance EXP CALCA protein results in increased abundance of Epinephrine CTD PMID:8058111 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Caly calcyon neuron-specific vesicular protein decreases secretion ISO CALY protein results in decreased secretion of Epinephrine CTD PMID:30753204 NCBI chr 1:194,862,671...194,873,861
Ensembl chr 1:194,862,672...194,873,551 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Epinephrine results in increased expression of CA2 mRNA CTD PMID:12729923 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO
EXP		 Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]; carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
Epinephrine results in increased expression of CASP3 protein
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]; Sildenafil Citrate inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Tadalafil inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]; Vardenafil Dihydrochloride inhibits the reaction [Epinephrine results in increased expression of CASP3 protein]		 CTD PMID:10728402 PMID:19135123 PMID:29233027 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases response to substance ISO CAT results in decreased susceptibility to Epinephrine CTD PMID:25172298 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]; Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]]
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Epinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]		 CTD PMID:9863660 PMID:12538206 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]
Epinephrine results in increased expression of CCND1 mRNA; Epinephrine results in increased expression of CCND1 protein
ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]		 CTD PMID:17680988 PMID:26964897 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Epinephrine results in decreased expression of CEBPB protein CTD PMID:31520687 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] CTD PMID:17498763 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation
multiple interactions		 ISO
EXP		 COMT protein results in increased methylation of Epinephrine
[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine		 CTD PMID:8821542 PMID:10064789 PMID:11160877 PMID:11248589 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO
EXP		 ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]		 CTD PMID:17680988 PMID:22496244 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases abundance		 EXP corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine]
CRH results in increased abundance of Epinephrine		 CTD PMID:1320258 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]] CTD PMID:1699227 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation
multiple interactions		 EXP Epinephrine results in increased phosphorylation of CTNNB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]		 CTD PMID:26964897 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsk cathepsin K increases expression ISO Epinephrine results in increased expression of CTSK mRNA CTD PMID:12729923 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein
Epinephrine results in increased expression of CYCS protein		 CTD PMID:19464573 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dbh dopamine beta-hydroxylase affects abundance ISO DBH gene polymorphism affects the abundance of Epinephrine CTD PMID:16163519 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Des desmin multiple interactions
decreases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein
Epinephrine results in decreased expression of DES protein		 CTD PMID:19464573 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein CTD PMID:19464573 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein CTD PMID:19464573 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884 		JBrowse link
G Epha4 Eph receptor A4 increases phosphorylation ISO Epinephrine results in increased phosphorylation of EPHA4 protein CTD PMID:22273509 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Etfb electron transfer flavoprotein subunit beta multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein CTD PMID:19464573 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068 		JBrowse link
G Fabp3 fatty acid binding protein 3 affects expression
multiple interactions		 EXP Epinephrine affects the expression of FABP3 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein		 CTD PMID:19464573 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fh fumarate hydratase increases expression EXP Epinephrine results in increased expression of FH protein CTD PMID:19464573 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Epinephrine results in decreased expression of FOXO1 protein CTD PMID:31520687 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gnb2 G protein subunit beta 2 multiple interactions ISO Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019 		JBrowse link
G Gnb4 G protein subunit beta 4 multiple interactions ISO Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579 		JBrowse link
G Gng12 G protein subunit gamma 12 multiple interactions ISO Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712 		JBrowse link
G Gng2 G protein subunit gamma 2 multiple interactions ISO Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183 		JBrowse link
G Gng3 G protein subunit gamma 3 multiple interactions ISO Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 1:205,731,837...205,733,603
Ensembl chr 1:205,731,837...205,733,603 		JBrowse link
G Gng4 G protein subunit gamma 4 multiple interactions ISO Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr17:86,448,708...86,497,560
Ensembl chr17:86,449,022...86,495,254 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions ISO Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 multiple interactions ISO Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein CTD PMID:19464573 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Epinephrine results in increased expression of HIF1A protein CTD PMID:36423730 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hk2 hexokinase 2 increases expression ISO Epinephrine results in increased expression of HK2 protein CTD PMID:36423730 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
affects localization		 EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]
Epinephrine affects the localization of HSF1 protein		 CTD PMID:19135123 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein CTD PMID:19464573 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein CTD PMID:19464573 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Epinephrine results in increased expression of HSPA8 protein CTD PMID:19464573 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein CTD PMID:19464573 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of HSPB6 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein		 CTD PMID:19464573 NCBI chr 1:85,806,898...85,809,072
Ensembl chr 1:85,806,146...85,809,071 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of IDH2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein		 CTD PMID:19464573 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Epinephrine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:10588509 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10588509 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 EXP
ISO		 Epinephrine results in decreased expression of IL6 mRNA
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:10588509 PMID:12423672 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO
EXP		 INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]
cilostamide inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; Cytochalasin B inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]		 CTD PMID:10777495 PMID:15172182 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression		 ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein]; Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] CTD PMID:1218171 PMID:6018752 PMID:6314140 PMID:32305330 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine] CTD PMID:16214444 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Epinephrine results in increased expression of ITGAV mRNA CTD PMID:12729923 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance EXP ITGB1 results in increased susceptibility to Epinephrine CTD PMID:14984413 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases expression
affects localization
increases activity		 ISO
EXP		 Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]
Epinephrine results in increased expression of LIPE mRNA
Epinephrine affects the localization of LIPE protein		 CTD PMID:7155675 PMID:10777495 PMID:11160373 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
affects activity		 ISO
EXP		 ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]
Epinephrine deficiency results in increased activity of MAPK1 protein
Epinephrine affects the activity of MAPK1 protein		 CTD PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
affects activity		 ISO
EXP		 ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]
Epinephrine deficiency results in increased activity of MAPK3 protein
Epinephrine affects the activity of MAPK3 protein		 CTD PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Meis1 Meis homeobox 1 decreases expression ISO Epinephrine results in decreased expression of MEIS1 protein CTD PMID:31520687 NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265 		JBrowse link
G Myl2 myosin light chain 2 multiple interactions
affects expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein
Epinephrine affects the expression of MYL2 protein		 CTD PMID:19464573 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Epinephrine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Epinephrine results in increased expression of NOS2 mRNA		 CTD PMID:16925470 PMID:19439816 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Epinephrine results in increased expression of NTF3 mRNA; Epinephrine results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases activity ISO Epinephrine results in decreased activity of P2RX7 protein CTD PMID:15459114 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions ISO Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate] CTD PMID:11413167 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases cleavage ISO Epinephrine results in decreased cleavage of PARP1 protein CTD PMID:36423730 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Epinephrine results in increased expression of PCNA protein CTD PMID:36423730 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Phb1 prohibitin 1 multiple interactions
increases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB1 protein
Epinephrine results in increased expression of PHB1 protein		 CTD PMID:19464573 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Epinephrine results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression		 EXP
ISO		 [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein
Epinephrine results in increased expression of PKM protein		 CTD PMID:19464573 PMID:36423730 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Epinephrine results in increased expression of PPARGC1A mRNA CTD PMID:22496244 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of PPP2R1A protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein		 CTD PMID:19464573 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein
Epinephrine results in decreased expression of PRDX6 protein		 CTD PMID:19464573 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Prkce protein kinase C, epsilon affects response to substance ISO
EXP		 PRKCE protein affects the susceptibility to Epinephrine CTD PMID:11454025 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Epinephrine results in decreased expression of PTGS2 mRNA; Epinephrine results in decreased expression of PTGS2 protein CTD PMID:31520687 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin multiple interactions
increases activity		 ISO ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] CTD PMID:6314140 PMID:8592096 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Sct secretin multiple interactions EXP Epinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP] CTD PMID:6312992 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Epinephrine results in increased expression of SERPINE1 mRNA CTD PMID:15850565 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake		 EXP
ISO		 [Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine
SLC22A3 protein results in increased uptake of Epinephrine		 CTD PMID:19053318 PMID:20858707 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Epinephrine CTD PMID:20858707 NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects binding
increases expression
increases activity		 ISO
EXP		 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Epinephrine binds to SOD1 protein mutant form
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 mRNA; Epinephrine results in increased expression of SOD1 protein		 CTD PMID:11163531 PMID:19464573 PMID:23612299 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity		 ISO
EXP		 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 mRNA; Epinephrine results in increased expression of SOD2 protein		 CTD PMID:11163531 PMID:19464573 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP Epinephrine results in increased expression of SUCLG2 protein CTD PMID:19464573 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170 		JBrowse link
G Th tyrosine hydroxylase increases chemical synthesis
multiple interactions		 ISO
EXP		 TH protein results in increased chemical synthesis of Epinephrine
[Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine		 CTD PMID:9822156 PMID:19067675 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions
decreases expression		 ISO Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1] CTD PMID:7558147 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases secretion		 ISO
EXP		 Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Epinephrine results in decreased expression of TNF mRNA
Epinephrine results in decreased secretion of TNF protein		 CTD PMID:10588509 PMID:12423672 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Epinephrine results in decreased expression of TP53 protein CTD PMID:36423730 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions		 EXP Epinephrine results in increased expression of VDAC1 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein		 CTD PMID:19464573 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Wnt4 Wnt family member 4 decreases expression ISO Epinephrine results in decreased expression of WNT4 mRNA; Epinephrine results in decreased expression of WNT4 protein CTD PMID:31520687 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein] CTD PMID:19135123 PMID:19464573 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle increases expression EXP Norepinephrine results in increased expression of ACTA1 mRNA CTD PMID:17592507 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO Norepinephrine results in increased expression of ACTA2 mRNA
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]; Carnosine inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]; FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA]		 CTD PMID:34609854 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ada adenosine deaminase multiple interactions
decreases response to substance		 ISO
EXP		 [ADA protein co-treated with Norepinephrine] results in increased secretion of Glycerol
Propranolol promotes the reaction [ADA protein results in decreased susceptibility to Norepinephrine]		 CTD PMID:7949234 PMID:17428236 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding
multiple interactions
increases activity
affects expression
affects response to substance		 ISO
EXP		 Norepinephrine binds to ADRA1A protein
[Norepinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1A protein; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]
Norepinephrine results in increased activity of ADRA1A protein
5-methylurapidil inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; [chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; BMY 7378 inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; chlorethylclonidine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Spiperone inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]
Norepinephrine affects the expression of ADRA1A protein
ADRA1A protein affects the susceptibility to Norepinephrine		 CTD PMID:8183249 PMID:10416824 PMID:12417256 PMID:20030735 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO [Norepinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1B protein; Norepinephrine inhibits the reaction [ADRA1B protein binds to Prazosin] CTD PMID:20030735 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
multiple interactions
affects response to substance		 ISO
EXP		 Norepinephrine binds to ADRA1D protein
[Norepinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1D protein; Norepinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]
ADRA1D affects the susceptibility to Norepinephrine
Norepinephrine binds to and affects the activity of ADRA1D protein		 CTD PMID:8183249 PMID:9639061 PMID:11901185 PMID:15493479 PMID:20030735 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adra2a adrenoceptor alpha 2A affects secretion
multiple interactions
affects abundance
affects binding		 EXP
ISO		 ADRA2A protein affects the secretion of Norepinephrine
[ADRA2A protein mutant form co-treated with ADRA2C protein mutant form] results in increased abundance of Norepinephrine
ADRA2A protein affects the abundance of Norepinephrine
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; [Norepinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; Brimonidine Tartrate inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Dexmedetomidine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Doxazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Norepinephrine binds to and results in increased activity of ADRA2A protein; Norepinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Prazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; talipexole inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Yohimbine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]
Norepinephrine binds to ADRA2A protein
[BRL 44408 binds to and results in decreased activity of ADRA2A protein] inhibits the reaction [Xylazine inhibits the reaction [Potassium results in increased secretion of Norepinephrine]]		 CTD PMID:10336518 PMID:10742289 PMID:11312645 PMID:20030735 PMID:20083574 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Norepinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA2B protein; Norepinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:20030735 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding
multiple interactions		 ISO Norepinephrine binds to ADRA2C protein
[ADRA2A protein mutant form co-treated with ADRA2C protein mutant form] results in increased abundance of Norepinephrine
[Norepinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA2C protein; Norepinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]		 CTD PMID:10336518 PMID:20030735 PMID:20083574 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP		 [Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB1 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]; Propranolol inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRB1 protein]
[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Norepinephrine		 CTD PMID:8096834 PMID:10344530 PMID:12010770 PMID:14730417 PMID:17200720 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects binding		 EXP
ISO		 [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]
[Norepinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB2 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein]; Propranolol inhibits the reaction [Norepinephrine binds to ADRB2 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]		 CTD PMID:7969507 PMID:10344530 PMID:14730417 PMID:24929186 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases activity		 ISO
EXP		 [Norepinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB3 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]
Norepinephrine results in increased activity of ADRB3 protein
3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Norepinephrine results in increased activity of ADRB3 protein]; Norepinephrine binds to and results in increased activity of ADRB3 protein		 CTD PMID:1682311 PMID:7815362 PMID:8569714 PMID:10344530 PMID:14730417 More... NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Agt angiotensinogen increases abundance
affects abundance
multiple interactions		 EXP AGT protein results in increased abundance of Norepinephrine
Norepinephrine affects the abundance of AGT protein
carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]		 CTD PMID:614752 PMID:15741261 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects response to substance ISO AGTR2 protein affects the susceptibility to Norepinephrine CTD PMID:11714657 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression EXP Norepinephrine results in decreased expression of AKT1 protein modified form CTD PMID:16338971 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Anxa1 annexin A1 multiple interactions ISO ANXA1 affects the reaction [Norepinephrine results in decreased secretion of IL6 protein] CTD PMID:16835395 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Norepinephrine results in decreased expression of AQP2 protein CTD PMID:16788141 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects abundance
decreases expression		 ISO
EXP		 ATP2A2 protein affects the abundance of Norepinephrine
Norepinephrine results in decreased expression of ATP2A2 mRNA		 CTD PMID:17592507 PMID:19328205 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Avp arginine vasopressin multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA CTD PMID:11742803 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of BAX protein]
Norepinephrine results in increased expression of BAX mRNA; Norepinephrine results in increased expression of BAX protein		 CTD PMID:18675472 PMID:20374255 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein] CTD PMID:14732211 PMID:17041759 PMID:20374255 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Norepinephrine results in decreased expression of BCL2L1 mRNA CTD PMID:18675472 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 affects the susceptibility to Norepinephrine CTD PMID:12105144 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G C5ar2 complement C5a receptor 2 increases expression EXP Norepinephrine results in increased expression of C5AR2 mRNA; Norepinephrine results in increased expression of C5AR2 protein CTD PMID:15715664 NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517 		JBrowse link
G Calca calcitonin-related polypeptide alpha affects response to substance
increases abundance
multiple interactions		 EXP CALCA protein affects the susceptibility to Norepinephrine
CALCA protein results in increased abundance of Norepinephrine
Propranolol promotes the reaction [CALCA protein affects the susceptibility to Norepinephrine]		 CTD PMID:8058111 PMID:18055875 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Caly calcyon neuron-specific vesicular protein increases secretion ISO CALY protein results in increased secretion of Norepinephrine CTD PMID:30753204 NCBI chr 1:194,862,671...194,873,861
Ensembl chr 1:194,862,672...194,873,551 		JBrowse link
G Casp12 caspase 12 multiple interactions
increases cleavage		 EXP CAT protein inhibits the reaction [Norepinephrine results in increased cleavage of CASP12 protein alternative form] CTD PMID:16338971 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp2 caspase 2 multiple interactions
increases activity		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein] CTD PMID:14732211 PMID:15158148 PMID:17041759 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression		 ISO
EXP		 Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein]; Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein
Norepinephrine results in increased activity of CASP3 protein
Norepinephrine results in increased cleavage of CASP3 protein
Norepinephrine results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of CASP3 protein]; Norepinephrine inhibits the reaction [Okadaic Acid results in increased activity of CASP3 protein]		 CTD PMID:11099166 PMID:14732211 PMID:15158148 PMID:16338971 PMID:17041759 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 multiple interactions
increases activity		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein] CTD PMID:14732211 PMID:15158148 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein]; Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein CTD PMID:17136323 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 affects activity EXP Norepinephrine affects the activity of CASP8 protein CTD PMID:25437044 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
affects activity
increases cleavage
increases activity		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]
Norepinephrine affects the activity of CASP9 protein
Norepinephrine results in increased cleavage of CASP9 protein		 CTD PMID:14732211 PMID:15158148 PMID:16338971 PMID:25437044 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [Norepinephrine results in increased cleavage of CASP12 protein alternative form] CTD PMID:16338971 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Norepinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]; Propranolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]] CTD PMID:9863660 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion
multiple interactions		 ISO Norepinephrine results in increased secretion of CCL5 protein
Prazosin inhibits the reaction [Norepinephrine results in increased secretion of CCL5 protein]		 CTD PMID:16782692 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Norepinephrine results in increased expression of CCN1 mRNA CTD PMID:15117851 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO Norepinephrine affects the expression of CNR1 mRNA CTD PMID:29650773 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 EXP
ISO		 carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]; Doxazosin inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]; FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]		 CTD PMID:10722803 PMID:14577597 PMID:19575289 PMID:34609854 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions		 EXP
ISO		 Norepinephrine results in increased expression of COL3A1 mRNA
[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]; Carnosine inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]; FPS-ZM1 inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]
carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]		 CTD PMID:10722803 PMID:14577597 PMID:34609854 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
increases methylation		 ISO [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine
COMT protein results in increased methylation of Norepinephrine		 CTD PMID:11160877 PMID:11248589 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP Norepinephrine results in decreased expression of CPT1A mRNA CTD PMID:19109942 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Norepinephrine results in increased expression of CREM mRNA CTD PMID:11171092 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases abundance		 EXP corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Norepinephrine]; Norepinephrine affects the expression of and affects the secretion of CRH protein; Propranolol affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]; Yohimbine affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]
CRH results in increased abundance of Norepinephrine		 CTD PMID:1320258 PMID:3497798 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine] CTD PMID:24398105 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Cycs cytochrome c, somatic affects localization
increases localization		 EXP Norepinephrine affects the localization of CYCS protein
Norepinephrine results in increased localization of CYCS protein		 CTD PMID:16338971 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dbh dopamine beta-hydroxylase affects abundance
increases abundance
decreases abundance		 ISO DBH gene polymorphism affects the abundance of Norepinephrine
DBH protein results in increased abundance of Norepinephrine
DBH mutant form results in decreased abundance of Norepinephrine		 CTD PMID:15148402 PMID:16163519 PMID:18329701 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Norepinephrine results in increased expression of DDIT3 mRNA; Norepinephrine results in increased expression of DDIT3 protein CTD PMID:16338971 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP Norepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Norepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 protein] CTD PMID:20887679 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO
EXP		 [Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium; Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 protein]		 CTD PMID:8032591 PMID:20887679 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
increases activity
decreases secretion
increases secretion		 EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; [EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; BQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]
Norepinephrine results in increased activity of EDN1 promoter		 CTD PMID:11435416 PMID:12184995 PMID:14759557 PMID:16023617 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Edn3 endothelin 3 multiple interactions
decreases secretion
increases secretion		 EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; 2-aminoethoxydiphenyl borate inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; [EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; bisindolylmaleimide I inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]; KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]; Picrotoxin inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 PMID:14759557 PMID:16023617 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Norepinephrine CTD PMID:15834289 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP [EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; [EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine CTD PMID:16023617 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Efhd2 EF-hand domain family, member D2 increases secretion ISO EFHD2 gene mutant form results in increased secretion of Norepinephrine CTD PMID:28397836 NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA CTD PMID:11742803 PMID:12632255 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP EGFR protein inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 increases expression EXP Norepinephrine results in increased expression of EGR1 CTD PMID:7905536 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions EXP [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein] CTD PMID:11880281 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 multiple interactions
increases expression		 ISO [Dexamethasone co-treated with Norepinephrine] results in increased expression of ELOVL3 mRNA; Dactinomycin inhibits the reaction [Norepinephrine results in increased expression of ELOVL3 mRNA]; Norepinephrine results in increased expression of and results in decreased degradation of ELOVL3 mRNA; rosiglitazone promotes the reaction [[Dexamethasone co-treated with Norepinephrine] results in increased expression of ELOVL3 mRNA] CTD PMID:17726147 NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115 		JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Norepinephrine CTD PMID:14732207 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Norepinephrine promotes the reaction [REL protein binds to F3 promoter]; Norepinephrine promotes the reaction [RELA protein binds to F3 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA] CTD PMID:23114885 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]; Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein] CTD PMID:11742803 PMID:15264218 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]] CTD PMID:11742803 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein; [Norepinephrine co-treated with Propranolol] results in increased expression of FN1 protein CTD PMID:11821714 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fndc5 fibronectin type III domain containing 5 decreases abundance EXP FNDC5 protein results in decreased abundance of Norepinephrine CTD PMID:32165127 NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO
EXP		 Norepinephrine results in increased expression of FOS mRNA
Norepinephrine results in increased expression of FOS; Norepinephrine results in increased expression of FOS mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Norepinephrine results in increased expression of FOS mRNA]		 CTD PMID:7605896 PMID:7905536 PMID:12729908 PMID:19225867 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Norepinephrine results in increased expression of FOSB CTD PMID:7905536 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; SHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein] CTD PMID:19168439 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of G6PD mRNA; Norepinephrine results in increased activity of G6PD protein
Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]
Norepinephrine results in increased expression of G6PD mRNA		 CTD PMID:1378361 PMID:7605896 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha multiple interactions EXP [Progesterone co-treated with Norepinephrine] results in increased expression of GABPA mRNA CTD PMID:16954335 NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605 		JBrowse link
G Gk glycerol kinase increases activity
increases expression		 EXP Norepinephrine results in increased activity of GK protein
Norepinephrine results in increased expression of GK mRNA		 CTD PMID:12736183 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631 		JBrowse link
G Gnas GNAS complex locus multiple interactions ISO Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein] CTD PMID:17200720 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Hdc histidine decarboxylase affects abundance ISO HDC protein affects the abundance of Norepinephrine CTD PMID:12421355 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Propranolol inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA] CTD PMID:24929186 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Norepinephrine results in increased expression of HSPA5 mRNA; Norepinephrine results in increased expression of HSPA5 protein CTD PMID:16338971 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions
increases expression		 EXP N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of HTR2B protein] CTD PMID:20374255 NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]; Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]; Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:23114885 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases response to substance		 EXP Prazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine] CTD PMID:17184500 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta affects secretion
increases expression
multiple interactions		 EXP Norepinephrine affects the secretion of IL1B protein
Norepinephrine results in increased expression of IL1B mRNA
carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL1B mRNA]; Norepinephrine promotes the reaction [IL1B protein results in increased expression of IL6 protein]		 CTD PMID:8392517 PMID:10722803 PMID:16386803 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases activity
decreases secretion		 ISO
EXP		 Norepinephrine results in increased expression of and results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [Norepinephrine results in increased expression of and results in increased secretion of IL6 protein]
Norepinephrine results in increased expression of IL6 mRNA; Norepinephrine results in increased expression of IL6 protein
Norepinephrine results in increased activity of IL6 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; ICI 118551 inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Norepinephrine promotes the reaction [IL1B protein results in increased expression of IL6 protein]; Norepinephrine promotes the reaction [TNF protein results in increased expression of IL6 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]
Norepinephrine results in decreased secretion of IL6 protein
ANXA1 affects the reaction [Norepinephrine results in decreased secretion of IL6 protein]		 CTD PMID:8392517 PMID:10722803 PMID:11406463 PMID:12619890 PMID:14577597 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP INS1 protein inhibits the reaction [[Theophylline co-treated with Norepinephrine] results in increased abundance of Cyclic AMP] CTD PMID:4306506 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
increases expression		 EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; Tetradecanoylphorbol Acetate promotes the reaction [Norepinephrine results in increased expression of JUN mRNA]
Norepinephrine results in increased expression of JUN; Norepinephrine results in increased expression of JUN mRNA		 CTD PMID:7905536 PMID:19225867 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Norepinephrine results in increased expression of JUNB CTD PMID:7905536 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects response to substance EXP KCNMA1 protein affects the susceptibility to Norepinephrine CTD PMID:22226998 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein; Phenoxybenzamine inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Piperoxan inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Prazosin inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein] CTD PMID:3953791 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases expression		 EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA] CTD PMID:9032464 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Maoa monoamine oxidase A increases metabolic processing
increases abundance		 ISO MAOA protein results in increased metabolism of Norepinephrine
MAOA mutant form results in increased abundance of Norepinephrine		 CTD PMID:10647887 PMID:11834493 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B increases abundance ISO MAOB mutant form results in increased abundance of Norepinephrine CTD PMID:11834493 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 Norepinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
Norepinephrine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin affects the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]		 CTD PMID:10788502 PMID:11054474 PMID:11880281 PMID:11914123 PMID:15292328 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Norepinephrine] CTD PMID:16949803 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 Norepinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK3 protein; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]		 CTD PMID:10788502 PMID:11054474 PMID:11880281 PMID:11914123 PMID:15292328 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK8 protein] CTD PMID:17041759 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
affects response to substance		 ISO MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Norepinephrine] CTD PMID:16949803 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
increases activity		 EXP
ISO		 Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Norepinephrine results in increased activity of and results in increased expression of MMP2 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased activity of MMP2 protein]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]		 CTD PMID:14577597 PMID:15326086 PMID:16864425 PMID:24929186 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
increases activity		 EXP
ISO		 trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]
Norepinephrine results in increased activity of MMP9 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; SR 11302 inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]		 CTD PMID:16864425 PMID:24929186 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 EXP [EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA
Norepinephrine results in increased expression of MYC		 CTD PMID:7605896 PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh6 myosin heavy chain 6 decreases expression EXP Norepinephrine results in decreased expression of MYH6 mRNA CTD PMID:17592507 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
affects expression
increases expression		 EXP Propranolol promotes the reaction [Norepinephrine results in increased expression of MYH7 mRNA]
Norepinephrine affects the expression of MYH7 mRNA		 CTD PMID:17592507 PMID:25437044 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myl1 myosin, light chain 1 multiple interactions
increases phosphorylation		 ISO
EXP		 PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]
chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]; CRT 0066101 inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]; fasudil inhibits the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]		 CTD PMID:37963515 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Norepinephrine results in increased expression of NFIL3 mRNA CTD PMID:12729908 NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization		 ISO Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Norepinephrine affects the localization of [NFKB1 protein binds to RELA protein]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]; Norepinephrine results in increased activity of [NFKB1 protein binds to RELA protein]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein] CTD PMID:16782692 PMID:23114885 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ngf nerve growth factor decreases expression EXP Norepinephrine results in decreased expression of NGF mRNA; Norepinephrine results in decreased expression of NGF protein CTD PMID:8593794 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects response to substance		 ISO [GW 274150 results in decreased activity of NOS2 protein] which results in increased susceptibility to Norepinephrine; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
NOS2 protein affects the susceptibility to Norepinephrine		 CTD PMID:16424707 PMID:19439816 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions		 ISO
EXP		 Norepinephrine results in increased expression of NPPA mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Norepinephrine results in increased expression of NPPA mRNA]		 CTD PMID:9788975 PMID:10722803 PMID:14577597 PMID:15240149 PMID:16714034 More... NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B affects abundance
decreases abundance		 ISO NPPB affects the abundance of Norepinephrine
NPPB protein results in decreased abundance of Norepinephrine		 CTD PMID:16333235 PMID:20339970 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Npy neuropeptide Y affects response to substance ISO NPY protein affects the susceptibility to Norepinephrine CTD PMID:15003356 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP [Estradiol co-treated with Norepinephrine] results in decreased expression of NRF1 mRNA CTD PMID:16954335 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Norepinephrine results in increased expression of NTF3 mRNA; Norepinephrine results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity EXP Norepinephrine results in decreased activity of ODC1 protein CTD PMID:1850525 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP [dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions EXP [dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Norepinephrine results in increased expression of PER1 mRNA CTD PMID:12729908 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Norepinephrine results in increased expression of PER2 mRNA CTD PMID:12729908 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Pgd phosphogluconate dehydrogenase multiple interactions
increases activity		 EXP carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD protein] CTD PMID:1378361 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Plcb1 phospholipase C beta 1 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCB1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]
Norepinephrine results in increased expression of PLCB1 mRNA; Norepinephrine results in increased expression of PLCB1 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb3 phospholipase C beta 3 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCB3 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]
Norepinephrine results in increased expression of PLCB3 mRNA; Norepinephrine results in increased expression of PLCB3 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plcd1 phospholipase C, delta 1 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCD1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]
Norepinephrine results in increased expression of PLCD1 mRNA; Norepinephrine results in increased expression of PLCD1 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCG1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]
Norepinephrine results in increased expression of PLCG1 mRNA; Norepinephrine results in increased expression of PLCG1 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Norepinephrine results in increased expression of PPARA mRNA CTD PMID:19109942 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Norepinephrine results in increased expression of PPARG mRNA CTD PMID:19109942 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 ISO
EXP		 [Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]
Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]		 CTD PMID:16513826 PMID:16954335 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A increases phosphorylation
multiple interactions		 EXP
ISO		 Norepinephrine results in increased phosphorylation of PPP1R12A protein
PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]
CRT 0066101 inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]; fasudil inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]		 CTD PMID:37963515 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A increases phosphorylation
multiple interactions		 EXP Norepinephrine results in increased phosphorylation of PPP1R14A protein
chelerythrine inhibits the reaction [Norepinephrine results in increased phosphorylation of PPP1R14A protein]		 CTD PMID:37963515 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671 		JBrowse link
G Prkd1 protein kinase D1 multiple interactions
increases phosphorylation		 ISO
EXP		 PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of MYL1 protein]; PRKD1 protein affects the reaction [Norepinephrine results in increased phosphorylation of PPP1R12A protein]
CRT 0066101 inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKD1 protein]		 CTD PMID:37963515 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNA; [Progesterone co-treated with Norepinephrine] results in increased expression of PTEN mRNA; Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA] CTD PMID:16954335 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Norepinephrine CTD PMID:15834289 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of REL protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of REL protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]; Norepinephrine promotes the reaction [REL protein binds to F3 promoter]; Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of REL protein]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:23114885 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine affects the localization of RELA protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]]; Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Norepinephrine affects the localization of [NFKB1 protein binds to RELA protein]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; Norepinephrine promotes the reaction [RELA protein binds to F3 promoter]; Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]; Norepinephrine results in increased activity of [NFKB1 protein binds to RELA protein]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of RELA protein]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of RELA protein] CTD PMID:16782692 PMID:23114885 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Norepinephrine results in increased expression of S100A8 mRNA; Norepinephrine results in increased expression of S100A8 protein CTD PMID:16677282 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Norepinephrine results in increased expression of S100A9 mRNA; Norepinephrine results in increased expression of S100A9 protein CTD PMID:16677282 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G S100b S100 calcium binding protein B increases expression
affects response to substance		 ISO Norepinephrine results in increased expression of S100B mRNA; Norepinephrine results in increased expression of S100B protein
S100B protein affects the susceptibility to Norepinephrine		 CTD PMID:9788975 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP Norepinephrine results in increased expression of SCD1 mRNA CTD PMID:22413010 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Norepinephrine results in increased expression of SERPINE1 mRNA CTD PMID:17429342 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions
increases expression		 EXP carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 protein]
Norepinephrine results in increased expression of SERPINH1 mRNA; Norepinephrine results in increased expression of SERPINH1 protein		 CTD PMID:10722803 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases phosphorylation		 EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; EGFR protein inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; Prazosin inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; RTKI cpd inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; SHC1 protein affects the reaction [Norepinephrine results in decreased expression of SOD2 protein]; SHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; U 0126 inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression EXP Norepinephrine results in decreased expression of SLC12A1 protein CTD PMID:16788141 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc14a2 solute carrier family 14 member 2 decreases expression EXP Norepinephrine results in decreased expression of SLC14A2 protein CTD PMID:16788141 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968 		JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions ISO Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions
decreases activity
affects binding		 EXP
ISO		 Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]
Norepinephrine results in decreased activity of SLC18A2 protein
Norepinephrine binds to SLC18A2 protein		 CTD PMID:1438304 PMID:7912402 PMID:15475732 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions		 ISO
EXP		 SLC22A3 protein results in increased uptake of Norepinephrine
Norepinephrine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]		 CTD PMID:9830022 PMID:20858707 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Norepinephrine CTD PMID:20858707 NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions
increases uptake
decreases expression
decreases uptake
decreases activity		 ISO
EXP		 N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A2 protein results in increased uptake of Norepinephrine]; Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein]; SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]
[Cullen corylifolium extract results in decreased activity of SLC6A2 protein] which results in decreased uptake of Norepinephrine; Norepinephrine affects the localization of and affects the metabolism of SLC6A2 protein
[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine; Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; tricaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]
Norepinephrine results in decreased expression of SLC6A2 protein
SLC6A2 mutant form results in decreased uptake of Norepinephrine
Norepinephrine results in decreased activity of SLC6A2 protein		 CTD PMID:11082428 PMID:11458707 PMID:16338971 PMID:16725121 PMID:17234900 More... NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases uptake		 ISO SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]
SLC6A3 protein results in increased uptake of Norepinephrine		 CTD PMID:17234900 PMID:17250655 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression EXP Norepinephrine results in increased expression of SLC8A1 mRNA; Norepinephrine results in increased expression of SLC8A1 protein CTD PMID:11179087 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Norepinephrine results in decreased expression of SOD2 protein
Norepinephrine results in increased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]
SHC1 protein affects the reaction [Norepinephrine results in decreased expression of SOD2 protein]		 CTD PMID:19168439 PMID:23114885 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein]; Carnosine inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein] CTD PMID:34609854 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions EXP [SQ 29548 binds to and results in decreased activity of TBXA2R protein] which results in decreased susceptibility to Norepinephrine CTD PMID:15834289 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Estradiol co-treated with Norepinephrine] results in decreased expression of TFAM mRNA; [Progesterone co-treated with Norepinephrine] results in increased expression of TFAM mRNA CTD PMID:16954335 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB1 mRNA] CTD PMID:15326086 PMID:19575289 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression
multiple interactions		 EXP Norepinephrine results in increased expression of TGFB2 mRNA; Norepinephrine results in increased expression of TGFB2 protein
Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA]		 CTD PMID:15326086 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression
multiple interactions		 EXP Norepinephrine results in increased expression of TGFB3 mRNA
Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA]		 CTD PMID:15326086 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases chemical synthesis		 EXP
ISO		 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine
TH protein results in increased chemical synthesis of Norepinephrine		 CTD PMID:9822156 PMID:19067675 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression
multiple interactions		 ISO Norepinephrine results in decreased expression of THY1
Propranolol inhibits the reaction [Norepinephrine results in decreased expression of THY1]		 CTD PMID:7558147 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions
increases expression		 EXP Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA] CTD PMID:14577597 PMID:15326086 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased secretion of TNF protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased secretion of TNF protein]; Norepinephrine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Norepinephrine promotes the reaction [TNF protein results in increased expression of IL6 protein]
Norepinephrine results in increased expression of TNF mRNA		 CTD PMID:8392517 PMID:15081246 PMID:15158148 PMID:25437044 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
increases expression		 ISO
EXP		 [Rosiglitazone results in increased susceptibility to Norepinephrine] which results in increased expression of UCP1 mRNA; [Rosiglitazone results in increased susceptibility to Norepinephrine] which results in increased expression of UCP1 protein; AG 1879 promotes the reaction [Norepinephrine results in increased expression of UCP1 mRNA]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA		 CTD PMID:10465291 PMID:10788502 PMID:11742803 PMID:29910772 PMID:31048375 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Norepinephrine results in increased expression of UCP2 mRNA CTD PMID:8593794 PMID:12588052 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [Norepinephrine results in increased metabolism of Lipids]; USF1 protein affects the reaction [Norepinephrine results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:83,845,230...83,854,875
Ensembl chr13:83,822,035...83,854,885 		JBrowse link
G Vdr vitamin D receptor increases abundance ISO VDR protein results in increased abundance of Norepinephrine CTD PMID:27450565 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO [Cobalt co-treated with Norepinephrine] results in increased expression of VEGFA mRNA; [Cycloheximide co-treated with Norepinephrine] results in increased expression of VEGFA mRNA; [Norepinephrine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA mRNA; AG 1879 inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; Cyclic AMP affects the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA] CTD PMID:10788502 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xbp1 X-box binding protein 1 affects localization EXP Norepinephrine affects the localization of XBP1 protein CTD PMID:16338971 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpinf1 serpin family F member 1 multiple interactions ISO epinephrine promotes the reaction [lipopolysaccharide increases expression of Serpinf1 protein in plasma] RGD PMID:9091588 RGD:11541073 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity		 ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein		 CTD PMID:7053299 PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Prl prolactin increases expression
increases secretion		 ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein		 CTD PMID:1867878 PMID:7265421 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
brimonidine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP		 Brimonidine Tartrate inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] CTD PMID:8397342 PMID:10742289 PMID:12208771 PMID:12598592 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Agt angiotensinogen multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased activity of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Brimonidine Tartrate inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation EXP Brimonidine Tartrate results in increased phosphorylation of CREB1 protein CTD PMID:17680988 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Prkca protein kinase C, alpha affects localization
multiple interactions		 EXP Brimonidine Tartrate affects the localization of PRKCA protein
Nitric Oxide deficiency promotes the reaction [Brimonidine Tartrate affects the localization of PRKCA protein]		 CTD PMID:12388232 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcd protein kinase C, delta affects localization
multiple interactions		 EXP Brimonidine Tartrate affects the localization of PRKCD protein
Nitric Oxide deficiency inhibits the reaction [Brimonidine Tartrate affects the localization of PRKCD protein]		 CTD PMID:12388232 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; bisindolylmaleimide I inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; Brimonidine Tartrate promotes the reaction [AGT protein results in increased activity of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:18250367 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Brimonidine Tartrate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
clonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP		 Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine		 CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
increases response to substance		 ISO
EXP		 Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine		 CTD PMID:8987795 PMID:10217548 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Avp arginine vasopressin increases expression EXP Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp2 caspase 2 increases activity ISO Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity		 EXP
ISO		 Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein		 CTD PMID:15351510 PMID:28115640 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing		 ISO [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine CTD PMID:31585114 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gal galanin and GMAP prepropeptide increases activity EXP Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions
increases expression		 ISO
EXP		 Clonidine results in increased secretion of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein		 CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 More... NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gnai1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ifng interferon gamma multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases secretion ISO Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]		 CTD PMID:12065299 PMID:16192389 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Ins2 insulin 2 decreases secretion ISO Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [Clonidine cotreated with Forearm Reperfusion Injury] increases expression of ITGAM protein in local neutrophils RGD PMID:22987052 RGD:329853767 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nppa natriuretic peptide A increases expression EXP Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y increases expression
multiple interactions
decreases expression		 EXP Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]		 CTD PMID:1878751 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases response to substance		 EXP [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine		 CTD PMID:8987795 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression		 ISO
EXP		 Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone		 CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prl prolactin increases expression
multiple interactions		 ISO
EXP		 Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]		 CTD PMID:1678730 PMID:16401171 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases activity
decreases activity
decreases expression
multiple interactions		 ISO Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein		 CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP		 Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
clonidine (amino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP		 Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine		 CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
increases response to substance		 ISO
EXP		 Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine		 CTD PMID:8987795 PMID:10217548 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Avp arginine vasopressin increases expression EXP Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp2 caspase 2 increases activity ISO Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity		 EXP
ISO		 Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein		 CTD PMID:15351510 PMID:28115640 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions		 ISO CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine		 CTD PMID:31585114 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gal galanin and GMAP prepropeptide increases activity EXP Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions
increases expression		 ISO
EXP		 Clonidine results in increased secretion of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein		 CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 More... NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gnai1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ifng interferon gamma multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases secretion ISO Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]		 CTD PMID:12065299 PMID:16192389 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Ins2 insulin 2 decreases secretion ISO Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nppa natriuretic peptide A increases expression EXP Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y increases expression
multiple interactions
decreases expression		 EXP Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]		 CTD PMID:1878751 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases response to substance		 EXP [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine		 CTD PMID:8987795 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression		 ISO
EXP		 Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone		 CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prl prolactin increases expression
multiple interactions		 ISO
EXP		 Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]		 CTD PMID:1678730 PMID:16401171 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases activity
decreases activity
decreases expression
multiple interactions		 ISO Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein		 CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP		 Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
clonidine (imino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor multiple interactions EXP [1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine binds to and results in decreased activity of ADORA1 protein] which results in decreased susceptibility to Clonidine CTD PMID:8987795 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP		 Clonidine binds to and results in increased activity of ADRA2A protein
[5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine results in decreased activity of ADRA2A protein] which results in decreased susceptibility to Clonidine		 CTD PMID:10217548 PMID:12560108 PMID:12598592 PMID:16595736 PMID:17934014 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO Clonidine binds to and results in increased activity of ADRA2B protein CTD PMID:10217548 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions
increases response to substance		 ISO
EXP		 Clonidine binds to and results in increased activity of ADRA2C protein
ADRA2C results in increased susceptibility to Clonidine		 CTD PMID:8987795 PMID:10217548 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Clonidine results in increased expression of AIFM1 protein CTD PMID:28115640 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO Clonidine results in decreased expression of APOA1 protein CTD PMID:2193493 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 decreases expression ISO Clonidine results in decreased expression of APOA2 protein CTD PMID:2193493 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Avp arginine vasopressin increases expression EXP Clonidine results in increased expression of AVP protein CTD PMID:7400963 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Clonidine results in increased expression of BAD protein CTD PMID:28115640 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Clonidine results in decreased expression of BCL2 protein CTD PMID:28115640 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Clonidine results in increased expression of BCL2L1 mRNA CTD PMID:12423672 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp2 caspase 2 increases activity ISO Clonidine results in increased activity of CASP2 protein CTD PMID:28115640 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases expression
increases activity		 EXP
ISO		 Clonidine results in increased expression of CASP3 mRNA
Clonidine results in increased activity of CASP3 protein		 CTD PMID:15351510 PMID:28115640 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO Clonidine results in increased activity of CASP8 protein CTD PMID:28115640 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Clonidine results in increased activity of CASP9 protein CTD PMID:28115640 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Clonidine inhibits the reaction [CFTR protein affects the transport of Chlorides] CTD PMID:12598592 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Clonidine results in increased expression of COMT mRNA CTD PMID:12423672 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions		 ISO CYP2D6 protein results in increased metabolism of Clonidine
[[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine; [CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine; [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine		 CTD PMID:31585114 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clonidine inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein] CTD PMID:12560108 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gal galanin and GMAP prepropeptide increases activity EXP Clonidine results in increased activity of GAL protein CTD PMID:10818254 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gh1 growth hormone 1 increases secretion
multiple interactions
increases expression		 ISO
EXP		 Clonidine results in increased secretion of GH1 protein
Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein]
L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein]
Clonidine results in increased expression of GH1; Clonidine results in increased expression of GH1 protein		 CTD PMID:707001 PMID:2568210 PMID:3007707 PMID:6150000 PMID:15099682 More... NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gnai1 G protein subunit alpha i1 affects response to substance ISO GNAI1 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai3 G protein subunit alpha i3 affects response to substance ISO GNAI3 affects the susceptibility to Clonidine CTD PMID:15207363 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Clonidine results in increased expression of HSP90AA1 mRNA CTD PMID:10684495 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clonidine results in increased expression of HSPD1 mRNA CTD PMID:10684495 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ifng interferon gamma multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IFNG protein] CTD PMID:16192389 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases secretion ISO Clonidine results in increased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1A protein] CTD PMID:16192389 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL1B protein]		 CTD PMID:12065299 PMID:16192389 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of IL2 protein] CTD PMID:16192389 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Ins2 insulin 2 decreases secretion ISO Clonidine results in decreased secretion of INS protein CTD PMID:707001 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nppa natriuretic peptide A increases expression EXP Clonidine results in increased expression of NPPA protein CTD PMID:18378355 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Npy neuropeptide Y increases expression
multiple interactions
decreases expression		 EXP Clonidine results in increased expression of NPY mRNA
Yohimbine inhibits the reaction [Clonidine results in decreased expression of NPY mRNA]		 CTD PMID:1878751 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases response to substance		 EXP [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine
OPRM1 results in increased susceptibility to Clonidine		 CTD PMID:8987795 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression ISO Clonidine results in decreased expression of PDCD4 mRNA CTD PMID:21873647 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Pomc proopiomelanocortin increases expression
multiple interactions
increases secretion
decreases expression		 ISO
EXP		 Clonidine results in increased expression of POMC protein
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Indomethacin inhibits the reaction [Clonidine results in increased secretion of POMC protein alternative form]
Clonidine results in decreased expression of POMC protein
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone		 CTD PMID:2455169 PMID:2846107 PMID:3039113 PMID:6089027 PMID:10898105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prl prolactin increases expression
multiple interactions		 ISO
EXP		 Clonidine results in increased expression of PRL protein
Clonidine inhibits the reaction [Fenfluramine results in increased secretion of PRL protein]		 CTD PMID:1678730 PMID:16401171 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Clonidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Clonidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ren renin increases activity
decreases activity
decreases expression
multiple interactions		 ISO Clonidine results in increased activity of REN protein
Clonidine results in decreased activity of REN protein
Clonidine results in decreased expression of REN protein
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein		 CTD PMID:238481 PMID:998518 PMID:3007707 PMID:3913757 PMID:6337028 More... NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] CTD PMID:16263091 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16263091 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO
EXP		 Clonidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
Clonidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:9830022 PMID:10966924 PMID:16263091 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Clonidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Clonidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO Clonidine results in increased activity of TAAR1 protein
[Clonidine results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine; Clonidine results in decreased activity of and results in decreased expression of TH protein; Clonidine results in increased activity of and results in increased expression of TH protein CTD PMID:19067675 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP BRL 44408 inhibits the reaction [Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein]]; Clonidine inhibits the reaction [Zymosan results in increased expression of TNF protein] CTD PMID:16192389 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Clonidine results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tpd52 tumor protein D52 increases expression ISO Clonidine results in increased expression of TPD52 mRNA CTD PMID:21873647 NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
dexmedetomidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Dexmedetomidine binds to and results in increased activity of ADRA2A protein; Dexmedetomidine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] CTD PMID:10742289 PMID:15627480 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of BAX protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of BAX protein] CTD PMID:30597158 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2 mRNA]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of BCL2 protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2 mRNA]] CTD PMID:20003127 PMID:34121490 PMID:36075570 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BCL2L1 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BCL2L1 protein] CTD PMID:30597158 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]		 CTD PMID:30102002 PMID:36858639 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 Dexmedetomidine results in increased activity of CASP3 protein
atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased cleavage of CASP3 protein]]; Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in increased expression of CASP3 protein]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased cleavage of CASP3 protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]		 CTD PMID:18724006 PMID:19352168 PMID:20003127 PMID:30597158 PMID:34121490 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO Dexmedetomidine results in increased activity of CASP7 protein CTD PMID:18724006 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Dexmedetomidine results in increased activity of CASP8 protein CTD PMID:18724006 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Dexmedetomidine results in increased activity of CASP9 protein CTD PMID:18724006 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of CCL2 mRNA] CTD PMID:31954762 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in increased expression of CDK5R1 protein] CTD PMID:31187143 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:15627480 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]]; atipamezole inhibits the reaction [Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A2 protein]; Dexmedetomidine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions EXP Dexmedetomidine inhibits the reaction [Propofol results in increased phosphorylation of DPYSL2 protein] CTD PMID:31187143 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of DUSP1 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of DUSP1 protein] CTD PMID:30597158 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GPT protein] CTD PMID:30597158 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsdmd gasdermin D multiple interactions ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]] CTD PMID:36858639 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of GSK3B protein]; Dexmedetomidine inhibits the reaction [Propofol results in decreased phosphorylation of and results in increased activity of GSK3B protein]
Dexmedetomidine results in increased phosphorylation of GSK3B protein		 CTD PMID:30597158 PMID:31187143 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 protein]]; atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of HMOX1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of HMOX1 protein]; Dexmedetomidine results in increased expression of and results in increased activity of HMOX1 protein
Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]
Dexmedetomidine results in increased expression of HMOX1 mRNA		 CTD PMID:30597158 PMID:36027947 PMID:36858639 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Dexmedetomidine affects the reaction [MIR330 protein affects the expression of HSPD1 mRNA]; Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of HSPD1 mRNA]; Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of HSPD1 protein] CTD PMID:34590382 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]] CTD PMID:36858639 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of IL1B mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]		 CTD PMID:30102002 PMID:31954762 PMID:36858639 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Dexmedetomidine promotes the reaction [prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]]; prolinedithiocarbamate promotes the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]		 CTD PMID:29723264 PMID:31954762 PMID:34121490 PMID:36075570 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]] CTD PMID:36858639 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP Dexmedetomidine affects the reaction [MIR330 protein affects the lipidation of MAP1LC3B protein]; Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased lipidation of MAP1LC3B protein] CTD PMID:34590382 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of MAPK1 protein] CTD PMID:36027947 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mir134 microRNA 134 multiple interactions EXP Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of MIR134 mRNA]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of BCL2 mRNA]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]] CTD PMID:34121490 NCBI chr 6:128,748,908...128,748,980 JBrowse link
G Mir330 microRNA 330 multiple interactions EXP Dexmedetomidine affects the reaction [MIR330 protein affects the expression of HSPD1 mRNA]; Dexmedetomidine affects the reaction [MIR330 protein affects the lipidation of MAP1LC3B protein]; Dexmedetomidine inhibits the reaction [Sevoflurane results in increased expression of MIR330 mRNA] CTD PMID:34590382 NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274 		JBrowse link
G Mir34a microRNA 34a decreases response to substance EXP MIR34A mRNA results in decreased susceptibility to Dexmedetomidine CTD PMID:35527005 NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103 		JBrowse link
G Mir381 microRNA 381 multiple interactions ISO [Dexmedetomidine co-treated with Lipopolysaccharides] results in increased expression of MIR381 mRNA; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:30102002 NCBI chr 6:128,740,976...128,741,036 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases phosphorylation		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]]; atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFE2L2 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 mRNA]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of NFE2L2 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased phosphorylation of NFE2L2 protein]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFE2L2 protein]
Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of and results in increased localization of NFE2L2 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of CASP1 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased cleavage of GSDMD protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL18 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of IL1B protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of LDHA protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]
Dexmedetomidine results in increased expression of NFE2L2 mRNA; Dexmedetomidine results in increased expression of NFE2L2 protein
Dexmedetomidine results in increased phosphorylation of NFE2L2 protein		 CTD PMID:30597158 PMID:36027947 PMID:36858639 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]
Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]]		 CTD PMID:30102002 PMID:36858639 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 protein] CTD PMID:30597158 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP Dexmedetomidine inhibits the reaction [Lidocaine results in increased expression of PRKCB protein] CTD PMID:30240660 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of RELA protein] CTD PMID:29723264 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of SOD1 protein] CTD PMID:36027947 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Dexmedetomidine promotes the reaction [prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; MIR134 inhibits the reaction [Dexmedetomidine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]]; prolinedithiocarbamate promotes the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR381 mRNA affects the reaction [Dexmedetomidine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]		 CTD PMID:29723264 PMID:30102002 PMID:31954762 PMID:34121490 PMID:36075570 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TP53 protein]]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TP53 protein] CTD PMID:30597158 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 multiple interactions EXP Dexmedetomidine inhibits the reaction [Sevoflurane results in decreased expression of ULK1 mRNA] CTD PMID:34590382 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
ergotamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein] CTD PMID:19121572 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Casp3 caspase 3 increases activity ISO Ergotamine results in increased activity of CASP3 protein CTD PMID:21295106 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein] CTD PMID:19121572 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Ergotamine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions ISO Ergotamine binds to and results in increased activity of HTR2B protein CTD PMID:11104741 NCBI chr 9:86,735,793...86,756,638
Ensembl chr 9:86,742,102...86,755,108 		JBrowse link
fenoldopam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A3galt2 alpha 1,3-galactosyltransferase 2 increases expression EXP Fenoldopam results in increased expression of A3GALT2 mRNA CTD PMID:21983523 NCBI chr 5:141,101,329...141,113,760
Ensembl chr 5:141,107,983...141,115,641 		JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression EXP Fenoldopam results in increased expression of ABL2 mRNA CTD PMID:21983523 NCBI chr13:68,673,702...68,770,846
Ensembl chr13:68,673,722...68,839,742 		JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Fenoldopam results in increased expression of ACTG1 mRNA CTD PMID:21983523 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression EXP Fenoldopam results in increased expression of ADAM9 mRNA CTD PMID:21983523 NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression EXP Fenoldopam results in decreased expression of ADAMTS4 mRNA CTD PMID:21983523 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065 		JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP Fenoldopam results in decreased expression of ATP2B2 mRNA CTD PMID:21983523 NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression EXP Fenoldopam results in increased expression of B4GALT1 mRNA CTD PMID:21983523 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Calu calumenin increases expression EXP Fenoldopam results in increased expression of CALU mRNA CTD PMID:21983523 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Cbx7 chromobox 7 decreases expression EXP Fenoldopam results in decreased expression of CBX7 mRNA CTD PMID:21983523 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression EXP Fenoldopam results in increased expression of CD55 mRNA CTD PMID:21983523 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression EXP Fenoldopam results in increased expression of CKAP4 mRNA CTD PMID:21983523 NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914 		JBrowse link
G Clic1 chloride intracellular channel 1 increases expression EXP Fenoldopam results in increased expression of CLIC1 mRNA CTD PMID:21983523 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712 		JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression EXP Fenoldopam results in increased expression of COL12A1 mRNA CTD PMID:21983523 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686 		JBrowse link
G Drd1 dopamine receptor D1 affects response to substance
multiple interactions		 EXP DRD1 protein affects the susceptibility to Fenoldopam
Fenoldopam binds to and results in increased activity of DRD1 protein		 CTD PMID:1724532 PMID:8103596 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Ecm2 extracellular matrix protein 2 decreases expression EXP Fenoldopam results in decreased expression of ECM2 mRNA CTD PMID:21983523 NCBI chr17:15,120,194...15,152,536
Ensembl chr17:15,120,196...15,152,516 		JBrowse link
G Eng endoglin increases expression EXP Fenoldopam results in increased expression of ENG mRNA CTD PMID:21983523 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Fenoldopam results in increased expression of ENPP3 mRNA CTD PMID:21983523 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression EXP Fenoldopam results in increased expression of ERP29 mRNA CTD PMID:21983523 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Fenoldopam results in increased expression of FGF2 protein CTD PMID:12180796 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fn1 fibronectin 1 increases expression EXP Fenoldopam results in increased expression of FN1 mRNA CTD PMID:21983523 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Fenoldopam results in decreased expression of HMGCS2 mRNA CTD PMID:21983523 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP Fenoldopam results in increased expression of KDELR3 mRNA CTD PMID:21983523 NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600 		JBrowse link
G Kpna2 karyopherin subunit alpha 2 increases expression EXP Fenoldopam results in increased expression of KPNA2 mRNA CTD PMID:21983523 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150 		JBrowse link
G Lgmn legumain increases expression EXP Fenoldopam results in increased expression of LGMN mRNA CTD PMID:21983523 NCBI chr 6:121,544,048...121,582,495
Ensembl chr 6:121,544,053...121,582,480 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Fenoldopam results in increased expression of LITAF mRNA CTD PMID:21983523 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763 		JBrowse link
G Loxl2 lysyl oxidase-like 2 increases expression EXP Fenoldopam results in increased expression of LOXL2 mRNA CTD PMID:21983523 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067 		JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Fenoldopam results in increased expression of LRAT mRNA CTD PMID:21983523 NCBI chr 2:168,264,093...168,273,155
Ensembl chr 2:168,266,877...168,273,619 		JBrowse link
G Myct1 myc target 1 increases expression EXP Fenoldopam results in increased expression of MYCT1 mRNA CTD PMID:21983523 NCBI chr 1:42,018,137...42,029,410
Ensembl chr 1:42,018,137...42,029,410 		JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Fenoldopam results in increased expression of NFKBIZ mRNA CTD PMID:21983523 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Fenoldopam results in increased expression of NOS2 protein CTD PMID:12180796 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression EXP Fenoldopam results in increased expression of NRIP3 mRNA CTD PMID:21983523 NCBI chr 1:163,789,738...163,815,036
Ensembl chr 1:163,789,738...163,815,600 		JBrowse link
G Omd osteomodulin decreases expression EXP Fenoldopam results in decreased expression of OMD mRNA CTD PMID:21983523 NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression EXP Fenoldopam results in increased expression of PDIA6 mRNA CTD PMID:21983523 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Fenoldopam results in increased expression of PGK1 mRNA CTD PMID:21983523 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Plp2 proteolipid protein 2 increases expression EXP Fenoldopam results in increased expression of PLP2 mRNA CTD PMID:21983523 NCBI chr  X:14,834,249...14,837,648
Ensembl chr  X:14,834,231...14,838,514 		JBrowse link
G Pros1 protein S increases expression EXP Fenoldopam results in increased expression of PROS1 mRNA CTD PMID:21983523 NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286 		JBrowse link
G Ptrh1 peptidyl-tRNA hydrolase 1 homolog increases expression EXP Fenoldopam results in increased expression of PTRH1 mRNA CTD PMID:21983523 NCBI chr 3:16,064,867...16,071,098
Ensembl chr 3:16,064,880...16,070,648 		JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP Fenoldopam results in increased expression of RAN mRNA CTD PMID:21983523 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases expression EXP Fenoldopam results in increased expression of RANGAP1 mRNA CTD PMID:21983523 NCBI chr 7:113,224,695...113,250,441
Ensembl chr 7:113,224,703...113,250,438 		JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression EXP Fenoldopam results in increased expression of S100A11 mRNA CTD PMID:21983523 NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044 		JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Fenoldopam results in increased expression of S100A4 mRNA CTD PMID:21983523 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Fenoldopam results in decreased expression of SLC2A4 mRNA CTD PMID:21983523 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression EXP Fenoldopam results in increased expression of SLC39A11 mRNA CTD PMID:21983523 NCBI chr10:98,275,958...98,697,042
Ensembl chr10:98,275,960...98,611,295 		JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression EXP Fenoldopam results in increased expression of SLC41A2 mRNA CTD PMID:21983523 NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO Fenoldopam results in increased activity of TAAR1 protein
[Fenoldopam results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Fenoldopam results in increased expression of TGFB1 protein CTD PMID:12180796 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP Fenoldopam results in increased expression of THBS1 mRNA CTD PMID:21983523 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Fenoldopam results in increased expression of TIMP1 mRNA CTD PMID:21983523 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Fenoldopam results in increased expression of TLR2 mRNA CTD PMID:21983523 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tmem97 transmembrane protein 97 increases expression EXP Fenoldopam results in increased expression of TMEM97 mRNA CTD PMID:21983523 NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730 		JBrowse link
G Tnc tenascin C increases expression EXP Fenoldopam results in increased expression of TNC mRNA CTD PMID:21983523 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Fenoldopam results in decreased expression of TNFSF10 mRNA CTD PMID:21983523 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tpm4 tropomyosin 4 increases expression EXP Fenoldopam results in increased expression of TPM4 mRNA CTD PMID:21983523 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984 		JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression EXP Fenoldopam results in increased expression of TUBB4B mRNA CTD PMID:21983523 NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP Fenoldopam results in increased expression of TUBB5 mRNA CTD PMID:21983523 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Fenoldopam results in increased expression of TUBB6 mRNA CTD PMID:21983523 NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418 		JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression EXP Fenoldopam results in increased expression of UBE2L3 mRNA CTD PMID:21983523 NCBI chr11:83,797,722...83,838,862
Ensembl chr11:83,797,722...83,838,862 		JBrowse link
G Vcan versican increases expression EXP Fenoldopam results in increased expression of VCAN mRNA CTD PMID:21983523 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
G Vwf von Willebrand factor affects expression EXP Fenoldopam affects the expression of VWF protein CTD PMID:11026604 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
methoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1d adrenoceptor alpha 1D affects binding ISO Methoxamine binds to ADRA1D protein CTD PMID:15493479 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion		 EXP Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein] CTD PMID:7816204 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of PTGS2 protein CTD PMID:12500202 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions EXP [Carbon Tetrachloride co-treated with Phenobarbital co-treated with Methoxamine] results in increased expression of TBXAS1 protein CTD PMID:12500202 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
midodrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Midodrine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Midodrine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
oxymetazoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions
affects binding		 ISO
EXP		 [Oxymetazoline binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA1A protein; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]
Oxymetazoline binds to ADRA1A protein		 CTD PMID:8196478 PMID:15872040 PMID:20030735 PMID:21544540 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
affects binding		 ISO Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Oxymetazoline binds to ADRA1B protein		 CTD PMID:20030735 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions
affects binding		 ISO Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
Oxymetazoline binds to ADRA1D protein		 CTD PMID:15493479 PMID:20030735 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions
affects binding		 ISO Oxymetazoline inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
Oxymetazoline binds to ADRA2A protein		 CTD PMID:20030735 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Oxymetazoline binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Oxymetazoline binds to and results in increased activity of ADRA2B protein; Oxymetazoline inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:20030735 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding
multiple interactions		 ISO Oxymetazoline binds to ADRA2C protein
Oxymetazoline inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]		 CTD PMID:20030735 NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 protein co-treated with NADP] results in increased metabolism of Oxymetazoline CTD PMID:21177487 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Oxymetazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression EXP Phenylephrine results in decreased expression of ABCC9 mRNA CTD PMID:18158353 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Phenylephrine results in increased expression of ABHD2 mRNA CTD PMID:18158353 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
increases phosphorylation
affects response to substance		 EXP ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]]; ABL1 protein affects the reaction [Phenylephrine promotes the reaction [CRK protein binds to WASL protein]]; ABL1 protein affects the reaction [Phenylephrine results in increased phosphorylation of BCAR1 protein]
Phenylephrine results in increased phosphorylation of ABL1 protein
ABL1 protein affects the susceptibility to Phenylephrine		 CTD PMID:17615370 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 decreases expression EXP Phenylephrine results in decreased expression of ABTB3 mRNA CTD PMID:18158353 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions
decreases expression		 EXP AICA ribonucleotide inhibits the reaction [Phenylephrine results in decreased expression of ACADM mRNA]; dorsomorphin promotes the reaction [Phenylephrine results in decreased expression of ACADM mRNA] CTD PMID:19699196 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP Phenylephrine results in increased expression of ACAT2 mRNA CTD PMID:18158353 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Ace angiotensin I converting enzyme affects response to substance ISO ACE protein affects the susceptibility to Phenylephrine CTD PMID:18431347 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Phenylephrine results in increased expression of ACOT2 mRNA CTD PMID:18158353 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions
increases expression		 ISO
EXP		 [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; [Phenylephrine results in increased activity of ITPR2 protein] which results in increased expression of ACTA1 mRNA; ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA]
MAPK8IP1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100A6 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; S100B protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; TGFB1I1 protein promotes the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]		 CTD PMID:10642269 PMID:10710348 PMID:11230109 PMID:11499749 PMID:11513749 More... NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP MYOCD protein affects the reaction [Phenylephrine results in increased expression of ACTA2 mRNA] CTD PMID:16556869 PMID:18158353 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actr3 actin related protein 3 increases expression EXP Phenylephrine results in increased expression of ACTR3 mRNA CTD PMID:18158353 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions EXP ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]; ADAM17 protein affects the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein] CTD PMID:16760267 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to Phenylephrine CTD PMID:12869393 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression EXP Phenylephrine results in decreased expression of ADHFE1 mRNA CTD PMID:18158353 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517 		JBrowse link
G Adm adrenomedullin multiple interactions
decreases response to substance
decreases expression
decreases secretion
increases expression		 EXP
ISO		 [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Phenylephrine results in increased expression of MYL2 mRNA]; ADM protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
ADM protein results in decreased susceptibility to Phenylephrine
Phenylephrine results in decreased expression of ADM mRNA
Phenylephrine results in decreased secretion of ADM protein
Phenylephrine results in increased expression of ADM mRNA; Phenylephrine results in increased expression of ADM protein		 CTD PMID:11470465 PMID:15370692 PMID:17250927 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654 		JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
increases expression		 EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]]; 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]]; ADORA1 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 mRNA]; N(6)-cyclopentyladenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein]
Phenylephrine results in increased expression of ADORA1 mRNA; Phenylephrine results in increased expression of ADORA1 protein		 CTD PMID:19966059 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adora2a adenosine A2a receptor multiple interactions
increases expression		 EXP 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; ADORA2A protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]
Phenylephrine results in increased expression of ADORA2A mRNA; Phenylephrine results in increased expression of ADORA2A protein		 CTD PMID:19966059 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Adora3 adenosine A3 receptor multiple interactions
increases expression		 EXP 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]]; 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]]; ADORA3 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; alpha,beta-methyleneadenosine 5'-diphosphate inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 mRNA]; N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein]
Phenylephrine results in increased expression of ADORA3 mRNA; Phenylephrine results in increased expression of ADORA3 protein		 CTD PMID:19966059 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 increases expression EXP Phenylephrine results in increased expression of ADPRHL1 mRNA CTD PMID:18158353 NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
affects response to substance
affects binding
increases response to substance
affects activity
increases activity		 ISO
EXP		 5-methylurapidil inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; [Colforsin co-treated with 1-Methyl-3-isobutylxanthine] affects the reaction [[Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium]; [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrine; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the abundance of Phosphatidylinositol 4,5-Diphosphate; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1A protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Phenylephrine binds to and results in increased activity of ADRA1A protein; Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; Ro 32-0432 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]
ADRA1A protein affects the susceptibility to Phenylephrine
Phenylephrine binds to ADRA1A protein
ADRA1A protein results in increased susceptibility to Phenylephrine
Phenylephrine affects the activity of ADRA1A protein
8-Hydroxy-2-(di-n-propylamino)tetralin promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; [Phenylephrine affects the activity of ADRA1A protein] which affects the transport of Potassium; [Phenylephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein; [Phenylephrine results in increased activity of ADRA1A protein] which results in increased transport of Glucose; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Calcium affects the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of EIF4EBP1 protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of MTOR protein]; Ethanol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in increased phosphorylation of RPS6KB1 protein]; GR 127935 promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Granisetron promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Lisuride promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Methysergide promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein]; Phenylephrine binds to and results in increased activity of ADRA1A protein		 CTD PMID:8183249 PMID:11709419 PMID:12935885 PMID:15306222 PMID:15365637 More... NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B affects response to substance
increases response to substance
multiple interactions
decreases expression
increases activity		 ISO
EXP		 ADRA1B protein affects the susceptibility to Phenylephrine
ADRA1B protein results in increased susceptibility to Phenylephrine
[Phenylephrine co-treated with ADRA1B protein] results in decreased expression of ATP2A2 protein; [Phenylephrine co-treated with ADRA1B protein] results in decreased expression of NPY protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of ACTA1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased expression of NPPA protein
4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; ADRA1B protein affects the reaction [Phenylephrine results in decreased activity of TGM2 protein]; chlorethylclonidine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]; Estradiol promotes the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine]
Phenylephrine results in decreased expression of ADRA1B mRNA; Phenylephrine results in decreased expression of ADRA1B protein
Phenylephrine results in increased activity of ADRA1B protein
[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1B protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]		 CTD PMID:10801782 PMID:11499749 PMID:11693201 PMID:15306222 PMID:16498073 More... NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects response to substance
increases activity
affects binding
multiple interactions
increases response to substance		 ISO
EXP		 ADRA1D protein affects the susceptibility to Phenylephrine
Phenylephrine results in increased activity of ADRA1D protein
Phenylephrine binds to ADRA1D protein
[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein; [Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein; [Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; carvedilol inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; carvedilol inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK1 protein]; Phentolamine inhibits the reaction [[Phenylephrine co-treated with ADRA1D protein] results in increased phosphorylation of MAPK3 protein]; Phentolamine inhibits the reaction [[Phenylephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
BMY 7378 inhibits the reaction [ADRA1D protein results in increased susceptibility to Phenylephrine]; Phenylephrine binds to and results in increased activity of ADRA1D protein
ADRA1D affects the susceptibility to Phenylephrine		 CTD PMID:8183249 PMID:11901185 PMID:15306222 PMID:15493479 PMID:16371063 More... NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]; Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]; Yohimbine inhibits the reaction [Brimonidine Tartrate promotes the reaction [Phenylephrine binds to and results in increased activity of ADRA2A protein]] CTD PMID:10742289 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Adra2b adrenoceptor alpha 2B affects response to substance
multiple interactions		 ISO ADRA2B protein affects the susceptibility to Phenylephrine
ADRA2B protein affects the susceptibility to [Phenylephrine co-treated with Acetylcholine]		 CTD PMID:16815979 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; CGP 20712A inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Salmeterol Xinafoate binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Pertussis Toxin promotes the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine] CTD PMID:16474418 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases response to substance		 ISO amibegron inhibits the reaction [ADRB3 protein results in increased susceptibility to Phenylephrine] CTD PMID:16022967 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Agt angiotensinogen affects response to substance
increases response to substance
multiple interactions
increases expression		 EXP
ISO		 AGT protein affects the susceptibility to Phenylephrine
AGT protein modified form results in increased susceptibility to Phenylephrine
AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]; carvedilol inhibits the reaction [AGT protein modified form promotes the reaction [Phenylephrine results in increased abundance of Inositol Phosphates]]; carvedilol inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]; irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
Phenylephrine results in increased expression of AGT mRNA; Phenylephrine results in increased expression of AGT protein
[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein; AGT protein promotes the reaction [Phenylephrine results in increased expression of FOS mRNA]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; PRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]		 CTD PMID:2298476 PMID:7900855 PMID:16251426 PMID:16794485 PMID:27094369 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
affects response to substance		 EXP
ISO		 [CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine
AGTR2 protein affects the susceptibility to Phenylephrine		 CTD PMID:11714657 PMID:19151255 NCBI chr  X:112,119,876...112,124,060
Ensembl chr  X:112,120,228...112,124,057 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Phenylephrine results in increased expression of AIFM1 protein CTD PMID:31605733 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Ak4 adenylate kinase 4 increases expression EXP Phenylephrine results in increased expression of AK4 mRNA CTD PMID:18158353 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation		 ISO
EXP		 Cyclosporine inhibits the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]
Phenylephrine affects the p