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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases expression |
EXP |
Perhexiline results in decreased expression of ABCB11 mRNA |
CTD |
PMID:27765674 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases expression decreases activity |
EXP ISO |
Perhexiline results in decreased expression of ABCB4 mRNA Perhexiline results in decreased activity of ABCB4 protein |
CTD |
PMID:27765674 PMID:28437613 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
EXP |
Perhexiline results in increased expression of ABCC2 mRNA |
CTD |
PMID:27765674 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
decreases expression |
EXP |
Perhexiline results in decreased expression of ABCC3 mRNA |
CTD |
PMID:27765674 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
decreases expression |
EXP |
Perhexiline results in decreased expression of ABCG5 mRNA |
CTD |
PMID:27765674 |
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NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Ap1s1 |
adaptor related protein complex 1 subunit sigma 1 |
decreases expression |
ISO |
Perhexiline results in decreased expression of AP1S1 mRNA |
CTD |
PMID:17175557 |
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NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713
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G |
Asah1 |
N-acylsphingosine amidohydrolase 1 |
increases expression |
ISO |
Perhexiline results in increased expression of ASAH1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Perhexiline results in increased expression of ASNS mRNA |
CTD |
PMID:17175557 |
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NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
Perhexiline inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] |
CTD |
PMID:18493746 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases response to substance |
ISO |
CYP2D6 protein results in decreased susceptibility to Perhexiline |
CTD |
PMID:28762043 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Depp1 |
DEPP1, autophagy regulator |
increases expression |
ISO |
Perhexiline results in increased expression of DEPP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
Perhexiline promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:19771169 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions |
ISO |
Perhexiline inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Perhexiline promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:19771169 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Fabp1 |
fatty acid binding protein 1 |
increases expression |
ISO |
Perhexiline results in increased expression of FABP1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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G |
Fndc4 |
fibronectin type III domain containing 4 |
increases expression |
ISO |
Perhexiline results in increased expression of FNDC4 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
Perhexiline results in increased expression of GDPD3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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G |
Hpn |
hepsin |
increases expression |
ISO |
Perhexiline results in increased expression of HPN mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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G |
Inhbe |
inhibin subunit beta E |
increases expression |
ISO |
Perhexiline results in increased expression of INHBE mRNA |
CTD |
PMID:17175557 |
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NCBI chr 7:63,177,558...63,178,983
Ensembl chr 7:63,176,219...63,179,172
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
affects binding |
ISO |
Perhexiline binds to KCNH2 protein |
CTD |
PMID:18701618 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Lss |
lanosterol synthase |
increases expression |
ISO |
Perhexiline results in increased expression of LSS mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
Perhexiline inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] |
CTD |
PMID:19771169 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
increases expression |
ISO |
Perhexiline results in increased expression of NR0B2 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
ISO |
Perhexiline results in increased expression of NUPR1 mRNA |
CTD |
PMID:17175557 |
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NCBI chr 1:181,213,292...181,215,327
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G |
Serpina3n |
serine (or cysteine) peptidase inhibitor, clade A, member 3N |
increases expression |
ISO |
Perhexiline results in increased expression of SERPINA3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
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G |
Slc10a1 |
solute carrier family 10 member 1 |
decreases expression |
EXP |
Perhexiline results in decreased expression of SLC10A1 mRNA |
CTD |
PMID:27765674 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Perhexiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc2a3 |
solute carrier family 2 member 3 |
increases expression decreases expression |
ISO |
Perhexiline results in increased expression of SLC2A3 mRNA Perhexiline results in decreased expression of SLC2A3 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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G |
Tagln |
transgelin |
decreases expression |
ISO |
Perhexiline results in decreased expression of TAGLN mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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G |
Wipi1 |
WD repeat domain, phosphoinositide interacting 1 |
increases expression |
ISO |
Perhexiline results in increased expression of WIPI1 mRNA |
CTD |
PMID:15342952 PMID:17175557 |
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NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
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