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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:heterocyclic organic fundamental parent
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Accession:CHEBI:35552 term browser browse the term
Synonyms:exact_synonym: heterocyclic parent hydrides
 related_synonym: heterocyclic fundamental parent;   organic heterocyclic fundamental parents


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3-isobutyl-1-methyl-7H-xanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
acyclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases activity EXP Acyclovir results in decreased activity of AVP protein CTD PMID:2724137 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883 		JBrowse link
allopurinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLN phospholamban affects expression EXP Allopurinol affects the expression of PLN mRNA; Allopurinol affects the expression of PLN protein; Allopurinol affects the expression of PLN protein modified form CTD PMID:17071724 NCBI chr 1:58,579,095...58,590,541
Ensembl chr 1:58,579,145...58,590,535 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 affects expression EXP Allopurinol affects the expression of SLC8A1 mRNA; Allopurinol affects the expression of SLC8A1 protein CTD PMID:17071724 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Eplerenone binds to and results in decreased activity of AR protein CTD PMID:23242577 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
styrene oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A12 cytochrome P-450 3A12 multiple interactions EXP CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674
G EPHX1 epoxide hydrolase 1 multiple interactions EXP CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 7:38,964,319...39,004,902
Ensembl chr 7:38,964,338...38,999,238 		JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Troleandomycin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:1618819 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501
    chemical entity 501
      atom 501
        nonmetal atom 494
          carbon atom 482
            organic molecular entity 482
              organic fundamental parent 75
                heterocyclic organic fundamental parent 11
                  mancude organic heterocyclic parent + 7
                  saturated organic heterocyclic parent + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 501
    subatomic particle 501
      composite particle 501
        hadron 501
          baryon 501
            nucleon 501
              atomic nucleus 501
                atom 501
                  main group element atom 494
                    main group molecular entity 494
                      s-block molecular entity 440
                        hydrogen molecular entity 439
                          hydrides 369
                            organic hydride 75
                              organic fundamental parent 75
                                heterocyclic organic fundamental parent 11
                                  mancude organic heterocyclic parent + 7
                                  saturated organic heterocyclic parent + 4
paths to the root