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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:perfluorodecanoic acid
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Accession:CHEBI:35546 term browser browse the term
Definition:A fluoroalkanoic acid that is perfluorinated decanoic acid.
Synonyms:exact_synonym: nonadecafluorodecanoic acid
 related_synonym: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluorodecanoic acid;   Formula=C10HF19O2;   InChI=1S/C10HF19O2/c11-2(12,1(30)31)3(13,14)4(15,16)5(17,18)6(19,20)7(21,22)8(23,24)9(25,26)10(27,28)29/h(H,30,31);   InChIKey=PCIUEQPBYFRTEM-UHFFFAOYSA-N;   Ndfda;   PFDA;   SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F;   nonadecafluoro-n-decanoic acid;   perfluoro-n-decanoic acid
 xref: Beilstein:1810811;   CAS:335-76-2;   Gmelin:35659
 xref_mesh: MESH:C036567
 xref: PMID:24367824;   PMID:24582365;   PMID:24630253;   Reaxys:1810811


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perfluorodecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO perfluorodecanoic acid results in increased expression of A2M mRNA CTD PMID:23567314 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO perfluorodecanoic acid results in increased expression of ABCA1 mRNA CTD PMID:35337807 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of ABCC2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]		 CTD PMID:27344344 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of ABCC3 mRNA
NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]		 CTD PMID:18757529 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression		 ISO gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] CTD PMID:18757529 PMID:27344344 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions
increases expression		 ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA] CTD PMID:27344344 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression ISO perfluorodecanoic acid results in increased expression of ACOT2 mRNA CTD PMID:35337807 NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases activity EXP perfluorodecanoic acid results in increased activity of ACOX1 protein CTD PMID:8001245 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO perfluorodecanoic acid results in increased expression of ACSL1 mRNA CTD PMID:23567314 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of AKT1 protein CTD PMID:19135466 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin affects binding EXP perfluorodecanoic acid binds to ALB protein CTD PMID:1606626 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Angptl4 angiopoietin-like 4 affects expression ISO perfluorodecanoic acid affects the expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Apoa2 apolipoprotein A2 affects expression ISO perfluorodecanoic acid affects the expression of APOA2 mRNA CTD PMID:23567314 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation
multiple interactions		 ISO perfluorodecanoic acid results in increased phosphorylation of ATF2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]		 CTD PMID:27344344 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO perfluorodecanoic acid results in increased expression of ATF3 mRNA CTD PMID:23567314 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO perfluorodecanoic acid results in increased expression of BAX mRNA CTD PMID:34358620 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bdh2 3-hydroxybutyrate dehydrogenase 2 increases expression ISO perfluorodecanoic acid results in increased expression of BDH2 mRNA CTD PMID:35337807 NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO Perfluorodecanoic acid increases expression of BIRC3 mRNA and protein in gastric adenocarcinoma cells RGD PMID:30431128 RGD:152998989 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B affects localization ISO perfluorodecanoic acid affects the localization of BUB1B protein CTD PMID:34358620 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547 		JBrowse link
G Casp3 caspase 3 increases expression ISO perfluorodecanoic acid results in increased expression of CASP3 mRNA CTD PMID:34358620 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases phosphorylation ISO perfluorodecanoic acid results in increased phosphorylation of CDK1 protein CTD PMID:34358620 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression ISO perfluorodecanoic acid affects the expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorodecanoic acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404 		JBrowse link
G Csf1 colony stimulating factor 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CSF1 protein CTD PMID:32916415 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Cstb cystatin B decreases expression ISO perfluorodecanoic acid results in decreased expression of CSTB protein CTD PMID:32916415 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CYP1A1 mRNA CTD PMID:23567314 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression
multiple interactions		 ISO perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]		 CTD PMID:27344344 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of CYP2B6 mRNA
perfluorodecanoic acid results in increased expression of CYP2B10 mRNA
NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA]		 CTD PMID:18648086 PMID:23567314 PMID:27344344 PMID:35337807 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO perfluorodecanoic acid results in decreased activity of CYP2C19 protein CTD PMID:35121066 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO perfluorodecanoic acid results in decreased activity of CYP2D6 protein CTD PMID:35121066 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
decreases activity		 ISO perfluorodecanoic acid results in increased expression of CYP3A4 mRNA
perfluorodecanoic acid results in decreased activity of CYP3A4 protein		 CTD PMID:23567314 PMID:35121066 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP perfluorodecanoic acid inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein] CTD PMID:15826607 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases expression EXP perfluorodecanoic acid results in increased expression of CYP4A2 mRNA CTD PMID:11752103 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP perfluorodecanoic acid results in increased expression of CYP4A3 mRNA CTD PMID:11752103 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
increases expression
multiple interactions		 ISO perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA
perfluorodecanoic acid results in increased expression of CYP7A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]		 CTD PMID:23567314 PMID:27344344 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CYP8B1 mRNA CTD PMID:27344344 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Dbi diazepam binding inhibitor increases expression EXP perfluorodecanoic acid results in increased expression of DBI mRNA; perfluorodecanoic acid results in increased expression of DBI protein CTD PMID:8499488 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO perfluorodecanoic acid results in increased expression of DDIT3 mRNA CTD PMID:23567314 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in increased expression of DRD2 mRNA CTD PMID:34371090 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP perfluorodecanoic acid results in increased expression of ECH1 protein CTD PMID:8160215 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions
increases expression		 ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA] CTD PMID:23567314 PMID:27344344 PMID:35337807 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO perfluorodecanoic acid binds to and results in increased activity of ESR1 protein CTD PMID:21163906 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO perfluorodecanoic acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO perfluorodecanoic acid results in decreased expression of FAS protein CTD PMID:32916415 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of FASN mRNA
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA]
NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA]		 CTD PMID:35337807 PMID:36423729 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf23 fibroblast growth factor 23 decreases expression ISO perfluorodecanoic acid results in decreased expression of FGF23 protein CTD PMID:32916415 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase multiple interactions ISO [perfluorodecanoic acid affects the methylation of FTCD gene] which affects the expression of FTCD mRNA CTD PMID:32653021 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO perfluorodecanoic acid results in increased expression of GCLM mRNA CTD PMID:23567314 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO perfluorodecanoic acid results in decreased expression of GDF15 protein CTD PMID:32916415 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression ISO perfluorodecanoic acid results in increased expression of GPAM mRNA CTD PMID:35337807 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
decreases activity		 ISO perfluorodecanoic acid results in increased activity of GPT protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]
perfluorodecanoic acid results in decreased activity of GPT protein		 CTD PMID:27344344 PMID:29156323 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO perfluorodecanoic acid results in increased expression of GSTM3 mRNA CTD PMID:35337807 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha affects expression ISO perfluorodecanoic acid affects the expression of HADHA mRNA CTD PMID:23567314 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO perfluorodecanoic acid results in decreased expression of HGF protein CTD PMID:32916415 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of HMGCS1 mRNA
[perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of HMGCS1 mRNA; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of HMGCS1 mRNA]
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of HMGCS1 mRNA]		 CTD PMID:35337807 PMID:36423729 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of HMGCS2 mRNA CTD PMID:23567314 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO perfluorodecanoic acid results in increased expression of HMOX1 mRNA CTD PMID:23567314 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hoxa5 homeo box A5 multiple interactions
increases expression		 ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA] CTD PMID:32534105 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234 		JBrowse link
G Hoxb7 homeo box B7 multiple interactions
increases expression		 ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA] CTD PMID:32534105 NCBI chr10:81,252,616...81,256,034
Ensembl chr10:81,252,553...81,256,034 		JBrowse link
G Hoxc5 homeo box C5 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of HOXC5 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]		 CTD PMID:32534105 NCBI chr 7:134,150,988...134,154,410
Ensembl chr 7:134,150,988...134,154,410 		JBrowse link
G Hoxd10 homeo box D10 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of HOXD10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]		 CTD PMID:32534105 NCBI chr 3:59,594,516...59,597,725
Ensembl chr 3:59,594,516...59,597,725 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases activity		 ISO Dithiothreitol inhibits the reaction [perfluorodecanoic acid results in decreased activity of HSD11B2 protein]; perfluorodecanoic acid inhibits the reaction [Dithiothreitol results in increased activity of HSD11B2 protein] CTD PMID:36878351 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity ISO
EXP		 perfluorodecanoic acid results in decreased activity of HSD3B1 protein CTD PMID:36122607 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases metabolic processing
increases phosphorylation		 EXP perfluorodecanoic acid results in increased metabolism of HSPA5 protein
perfluorodecanoic acid results in increased phosphorylation of HSPA5 protein		 CTD PMID:7880882 PMID:7958552 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of IL10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]		 CTD PMID:27344344 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il16 interleukin 16 decreases expression ISO perfluorodecanoic acid results in decreased expression of IL16 protein CTD PMID:32916415 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il18 interleukin 18 increases secretion
increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased secretion of IL18 protein
perfluorodecanoic acid results in increased expression of IL18 mRNA
[perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of IL18 mRNA; [perfluorodecanoic acid co-treated with Oleic Acid] results in increased secretion of IL18 protein		 CTD PMID:36423729 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of IL1B mRNA
perfluorodecanoic acid results in increased secretion of IL1B protein
[perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of IL1B mRNA; [perfluorodecanoic acid co-treated with Oleic Acid] results in increased secretion of IL1B protein		 CTD PMID:36423729 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 decreases expression ISO perfluorodecanoic acid results in decreased expression of IL6 protein CTD PMID:32916415 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga1 integrin subunit alpha 1 affects expression ISO perfluorodecanoic acid affects the expression of ITGA1 protein CTD PMID:33677611 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO perfluorodecanoic acid inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:19135466 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:19135466 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mbl2 mannose binding lectin 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression ISO perfluorodecanoic acid affects the expression of MMP1 protein CTD PMID:33677611 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO perfluorodecanoic acid results in decreased expression of MMP12 protein CTD PMID:32916415 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611 		JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 increases expression ISO perfluorodecanoic acid results in increased expression of MOGAT1 mRNA CTD PMID:23567314 NCBI chr 9:79,980,963...79,988,513
Ensembl chr 9:79,956,649...79,988,513 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO perfluorodecanoic acid results in increased expression of MTTP mRNA CTD PMID:35337807 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]
perfluorodecanoic acid results in increased expression of NFE2L2 mRNA		 CTD PMID:18757529 PMID:35337807 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of FASN mRNA]; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of HMGCS1 mRNA]; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of SCD mRNA] CTD PMID:36423729 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO perfluorodecanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO perfluorodecanoic acid results in increased expression of NQO1 mRNA CTD PMID:35337807 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
increases activity		 EXP
ISO		 Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]
perfluorodecanoic acid results in increased activity of NR1I2 protein
perfluorodecanoic acid results in increased expression of NR1I2 mRNA		 CTD PMID:15826607 PMID:28115241 PMID:35337807 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
multiple interactions
increases expression
affects localization		 ISO NR1I3 protein affects the susceptibility to perfluorodecanoic acid
NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA]
perfluorodecanoic acid results in increased expression of NR1I3 mRNA
perfluorodecanoic acid affects the localization of NR1I3 protein		 CTD PMID:18648086 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO perfluorodecanoic acid results in increased expression of PCK2 mRNA CTD PMID:35337807 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorodecanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of PDX1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]		 CTD PMID:32534105 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064 		JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorodecanoic acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorodecanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects response to substance
increases activity
increases expression		 ISO PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A6A mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A7C mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]
PPARA protein affects the susceptibility to perfluorodecanoic acid
perfluorodecanoic acid results in increased activity of PPARA protein
perfluorodecanoic acid results in increased expression of PPARA mRNA		 CTD PMID:18648086 PMID:18703564 PMID:18757529 PMID:23391484 PMID:27344344 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
increases expression		 ISO perfluorodecanoic acid results in increased activity of PPARG protein
perfluorodecanoic acid results in increased expression of PPARG mRNA		 CTD PMID:23391484 PMID:24998974 PMID:35337807 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorodecanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions		 ISO perfluorodecanoic acid results in decreased phosphorylation of RELA protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]		 CTD PMID:27344344 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Retn resistin decreases expression ISO perfluorodecanoic acid results in decreased expression of RETN protein CTD PMID:32916415 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of SCD1 mRNA
perfluorodecanoic acid results in increased expression of SCD mRNA
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of SCD1 mRNA]
[perfluorodecanoic acid co-treated with Oleic Acid] results in increased expression of SCD mRNA; NLRP3 protein affects the reaction [perfluorodecanoic acid results in increased expression of SCD mRNA]		 CTD PMID:23567314 PMID:35337807 PMID:36423729 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpind1 serpin family D member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPIND1 mRNA CTD PMID:23567314 NCBI chr11:83,664,517...83,675,593
Ensembl chr11:83,664,518...83,675,519 		JBrowse link
G Serpinf2 serpin family F member 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPINF2 mRNA CTD PMID:23567314 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions		 ISO perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA; perfluorodecanoic acid results in decreased expression of SLC10A1 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]		 CTD PMID:18703564 PMID:27344344 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] CTD PMID:20639259 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate] CTD PMID:19915082 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression
multiple interactions		 ISO perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1A4 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]
perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]		 CTD PMID:18703564 PMID:20639259 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions		 ISO perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1B2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]		 CTD PMID:18703564 PMID:27344344 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO perfluorodecanoic acid results in increased expression of SOD1 mRNA CTD PMID:35337807 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spon1 spondin 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of SPON1 protein CTD PMID:32916415 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of SREBF1 mRNA
benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [perfluorodecanoic acid results in increased expression of SREBF1 mRNA]		 CTD PMID:36423729 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP perfluorodecanoic acid results in decreased expression of SULT1A1 protein CTD PMID:8620580 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP perfluorodecanoic acid results in decreased expression of SULT1C1 protein CTD PMID:8620580 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases expression ISO perfluorodecanoic acid results in increased expression of SULT2A1 mRNA CTD PMID:35337807 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [perfluoro-n-nonanoic acid co-treated with perfluorodecanoic acid co-treated with perfluoroundecanoic acid co-treated with perfluorododecanoic acid co-treated with perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid] results in decreased expression of TH mRNA CTD PMID:34371090 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO perfluorodecanoic acid binds to THRA protein CTD PMID:24819616 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of TNF protein
gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]		 CTD PMID:18757529 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO perfluorodecanoic acid results in decreased expression of TNFRSF1B protein CTD PMID:32916415 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO perfluorodecanoic acid results in increased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of UCP2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]		 CTD PMID:27344344 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of UGT1A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]		 CTD PMID:27344344 PMID:35337807 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions		 ISO perfluorodecanoic acid results in increased expression of UGT1A2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]		 CTD PMID:27344344 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression		 ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA] CTD PMID:27344344 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO perfluorodecanoic acid results in decreased expression of VEGFA protein CTD PMID:32916415 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions
increases expression		 ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA] CTD PMID:32534105 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 multiple interactions ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA] CTD PMID:32534105 NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        xenobiotic 18731
          perfluorodecanoic acid 121
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        fatty acid 16689
                                          saturated fatty acid 16375
                                            straight-chain saturated fatty acid 15875
                                              decanoic acid 129
                                                perfluorodecanoic acid 121
paths to the root