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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perfluorodecanoic acid
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Accession:CHEBI:35546 term browser browse the term
Definition:A fluoroalkanoic acid that is perfluorinated decanoic acid.
Synonyms:exact_synonym: nonadecafluorodecanoic acid
 related_synonym: 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluorodecanoic acid;   Formula=C10HF19O2;   InChI=1S/C10HF19O2/c11-2(12,1(30)31)3(13,14)4(15,16)5(17,18)6(19,20)7(21,22)8(23,24)9(25,26)10(27,28)29/h(H,30,31);   InChIKey=PCIUEQPBYFRTEM-UHFFFAOYSA-N;   Ndfda;   PFDA;   SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F;   nonadecafluoro-n-decanoic acid;   perfluoro-n-decanoic acid
 xref: Beilstein:1810811;   CAS:335-76-2;   Gmelin:35659
 xref_mesh: MESH:C036567
 xref: PMID:24367824;   PMID:24582365;   PMID:24630253;   Reaxys:1810811


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perfluorodecanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO perfluorodecanoic acid results in increased expression of A2M mRNA CTD PMID:23567314 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of ABCC2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]
CTD PMID:27344344 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of ABCC3 mRNA
NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]
CTD PMID:18757529 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression
ISO gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] CTD PMID:18757529, PMID:27344344 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA] CTD PMID:27344344 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases activity EXP perfluorodecanoic acid results in increased activity of ACOX1 protein CTD PMID:8001245 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO perfluorodecanoic acid results in increased expression of ACSL1 mRNA CTD PMID:23567314 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of AKT1 protein CTD PMID:19135466 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin affects binding EXP perfluorodecanoic acid binds to ALB protein CTD PMID:1606626 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Angptl4 angiopoietin-like 4 affects expression ISO perfluorodecanoic acid affects the expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Apoa2 apolipoprotein A2 affects expression ISO perfluorodecanoic acid affects the expression of APOA2 mRNA CTD PMID:23567314 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation
multiple interactions
ISO perfluorodecanoic acid results in increased phosphorylation of ATF2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]
CTD PMID:27344344 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO perfluorodecanoic acid results in increased expression of ATF3 mRNA CTD PMID:23567314 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression ISO perfluorodecanoic acid affects the expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorodecanoic acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CYP1A1 mRNA CTD PMID:23567314 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]
CTD PMID:27344344 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA] CTD PMID:18648086, PMID:27344344 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO perfluorodecanoic acid results in increased expression of CYP2B6 mRNA CTD PMID:23567314 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP perfluorodecanoic acid inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of CYP3A23-3A1 protein] CTD PMID:15826607 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases expression EXP perfluorodecanoic acid results in increased expression of CYP4A2 mRNA CTD PMID:11752103 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases expression EXP perfluorodecanoic acid results in increased expression of CYP4A3 mRNA CTD PMID:11752103 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
increases expression
ISO perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]
perfluorodecanoic acid results in increased expression of CYP7A1 mRNA
CTD PMID:23567314, PMID:27344344 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of CYP8B1 mRNA CTD PMID:27344344 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein increases expression EXP perfluorodecanoic acid results in increased expression of DBI mRNA; perfluorodecanoic acid results in increased expression of DBI protein CTD PMID:8499488 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO perfluorodecanoic acid results in increased expression of DDIT3 mRNA CTD PMID:23567314 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP perfluorodecanoic acid results in increased expression of ECH1 protein CTD PMID:8160215 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA] CTD PMID:23567314, PMID:27344344 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO perfluorodecanoic acid binds to and results in increased activity of ESR1 protein CTD PMID:21163906 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO perfluorodecanoic acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO perfluorodecanoic acid results in increased expression of GCLM mRNA CTD PMID:23567314 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
ISO perfluorodecanoic acid results in increased activity of GPT protein
PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]
CTD PMID:27344344 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha affects expression ISO perfluorodecanoic acid affects the expression of HADHA mRNA CTD PMID:23567314 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of HMGCS2 mRNA CTD PMID:23567314 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO perfluorodecanoic acid results in increased expression of HMOX1 mRNA CTD PMID:23567314 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hoxa5 homeo box A5 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA] CTD PMID:32534105
G Hoxb7 homeo box B7 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA] CTD PMID:32534105 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637
JBrowse link
G Hoxc5 homeo box C5 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of HOXC5 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]
CTD PMID:32534105 NCBI chr 7:144,628,120...144,631,542
Ensembl chr 7:144,628,120...144,631,542
JBrowse link
G Hoxd10 homeo box D10 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of HOXD10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]
CTD PMID:32534105 NCBI chr 3:61,614,133...61,617,342
Ensembl chr 3:61,613,774...61,617,367
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases metabolic processing
increases phosphorylation
EXP perfluorodecanoic acid results in increased metabolism of HSPA5 protein
perfluorodecanoic acid results in increased phosphorylation of HSPA5 protein
CTD PMID:7880882, PMID:7958552 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of IL10 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]
CTD PMID:27344344 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK1 protein CTD PMID:19135466 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO perfluorodecanoic acid results in decreased phosphorylation of MAPK3 protein CTD PMID:19135466 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mbl2 mannose binding lectin 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 increases expression ISO perfluorodecanoic acid results in increased expression of MOGAT1 mRNA CTD PMID:23567314 NCBI chr 9:84,405,481...84,418,657
Ensembl chr 9:84,405,477...84,418,591
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA] CTD PMID:18757529 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO perfluorodecanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
increases expression
EXP
ISO
Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]
perfluorodecanoic acid results in increased activity of NR1I2 protein
CTD PMID:15826607, PMID:28115241 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
affects localization
increases expression
multiple interactions
ISO NR1I3 protein affects the susceptibility to perfluorodecanoic acid
perfluorodecanoic acid affects the localization of NR1I3 protein
perfluorodecanoic acid results in increased expression of NR1I3 mRNA
NR1I3 protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP2B10 mRNA]
CTD PMID:18648086 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorodecanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of PDX1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]
CTD PMID:32534105 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorodecanoic acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorodecanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
affects response to substance
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP27A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of CYP7A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased activity of GPT protein]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC3 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ACOT1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of EHHADH mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXA5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXB7 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXC5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of HOXD10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of IL10 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of PDX1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A6A mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A7C mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA]; PPARA protein affects the reaction [perfluorodecanoic acid results in increased phosphorylation of ATF2 protein]
perfluorodecanoic acid results in increased activity of PPARA protein
PPARA protein affects the susceptibility to perfluorodecanoic acid
CTD PMID:18648086, PMID:18703564, PMID:18757529, PMID:23391484, PMID:27344344, PMID:32534105 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO perfluorodecanoic acid results in increased activity of PPARG protein CTD PMID:23391484, PMID:24998974 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorodecanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases phosphorylation
multiple interactions
ISO perfluorodecanoic acid results in decreased phosphorylation of RELA protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased phosphorylation of RELA protein]
CTD PMID:27344344 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO perfluorodecanoic acid results in increased expression of SCD1 mRNA CTD PMID:23567314 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Serpind1 serpin family D member 1 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPIND1 mRNA CTD PMID:23567314 NCBI chr11:87,913,814...87,924,880
Ensembl chr11:87,913,806...87,924,816
JBrowse link
G Serpinf2 serpin family F member 2 decreases expression ISO perfluorodecanoic acid results in decreased expression of SERPINF2 mRNA CTD PMID:23567314 NCBI chr10:62,264,247...62,272,353
Ensembl chr10:62,264,788...62,273,119
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA; perfluorodecanoic acid results in decreased expression of SLC10A1 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLC10A1 mRNA]
CTD PMID:18703564, PMID:27344344 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] CTD PMID:20639259 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP perfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate] CTD PMID:19915082 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1A4 protein
perfluorodecanoic acid inhibits the reaction [SLCO1A2 protein results in increased import of estrone sulfate]
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1A4 mRNA]
CTD PMID:18703564, PMID:20639259 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
ISO perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA; perfluorodecanoic acid results in decreased expression of SLCO1B2 protein
PPARA protein affects the reaction [perfluorodecanoic acid results in decreased expression of SLCO1B2 mRNA]
CTD PMID:18703564, PMID:27344344 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP perfluorodecanoic acid results in decreased expression of SULT1A1 protein CTD PMID:8620580 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP perfluorodecanoic acid results in decreased expression of SULT1C1 protein CTD PMID:8620580 NCBI chr 9:4,931,038...4,978,847
Ensembl chr 9:4,930,818...4,978,892
JBrowse link
G Thra thyroid hormone receptor alpha affects binding ISO perfluorodecanoic acid binds to THRA protein CTD PMID:24819616 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of TNF protein
gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]
CTD PMID:18757529 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorodecanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO perfluorodecanoic acid results in increased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Ucp2 uncoupling protein 2 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of UCP2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UCP2 mRNA]
CTD PMID:27344344 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of UGT1A1 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A1 mRNA]
CTD PMID:27344344 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of UGT1A2 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A2 mRNA]
CTD PMID:27344344 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression
multiple interactions
ISO perfluorodecanoic acid results in increased expression of UGT1A5 mRNA
PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of UGT1A5 mRNA]
CTD PMID:27344344 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions
increases expression
ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB1 mRNA] CTD PMID:32534105 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zeb2 zinc finger E-box binding homeobox 2 multiple interactions ISO PPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ZEB2 mRNA] CTD PMID:32534105 NCBI chr 3:29,857,289...29,985,932
Ensembl chr 3:29,862,473...29,996,865
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          perfluorodecanoic acid 77
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            saturated fatty acid 15812
                                              straight-chain saturated fatty acid 15227
                                                decanoic acid 85
                                                  perfluorodecanoic acid 77
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.