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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
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Accession:CHEBI:35544 term browser browse the term
Definition:A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Synonyms:related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor;   (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors;   (PG)H synthase inhibitor;   (PG)H synthase inhibitors;   COX inhibitor;   EC 1.14.99.1 (cyclooxygenase) inhibitor;   EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors;   EC 1.14.99.1 inhibitor;   EC 1.14.99.1 inhibitors;   PG synthetase inhibitor;   PG synthetase inhibitors;   cyclooxygenase (EC 1.14.99.1) inhibitors;   cyclooxygenase inhibitor;   cyclooxygenase inhibitors;   fatty acid cyclooxygenase inhibitor;   fatty acid cyclooxygenase inhibitors;   prostaglandin G/H synthase inhibitor;   prostaglandin G/H synthase inhibitors;   prostaglandin endoperoxide synthetase inhibitor;   prostaglandin endoperoxide synthetase inhibitors;   prostaglandin synthase inhibitor;   prostaglandin synthase inhibitors;   prostaglandin synthetase inhibitor;   prostaglandin synthetase inhibitors


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      CHEBI ontology 19811
        role 19818
          biological role 19785
            biochemical role 19496
              enzyme inhibitor 18702
                EC 1.* (oxidoreductase) inhibitor 17503
                  EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 15945
                    EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 14198
                      EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor 14220
                        (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
                        (6-methoxy-2-naphthyl)acetic acid 0
                        3',5'-di-O-methyltricetin + 1
                        4-(methylamino)antipyrine 0
                        4-aminoantipyrine 0
                        aceclofenac 4
                        acemetacin 1
                        aiphanol 0
                        ampiroxicam 0
                        carprofen + 0
                        clonixin 0
                        clonixin lysine salt 0
                        cudratricusxanthone A 11
                        cyclooxygenase 1 inhibitor + 13113
                        cyclooxygenase 2 inhibitor + 13631
                        cyclooxygenase 3 inhibitor + 12945
                        diclofenac + 1114
                        flufenamic acid 42
                        flunixin 1
                        flunixin meglumine 0
                        flurbiprofen + 109
                        ibufenac 0
                        indometacin + 3437
                        indoprofen 14
                        ketoprofen 27
                        lonazolac 0
                        lonazolac calcium 0
                        loxoprofen + 8
                        loxoprofen sodium + 0
                        loxoprofen sodium hydrate 0
                        meclofenamic acid 11
                        mefenamic acid 35
                        naproxcinod 0
                        nitrosulindac 0
                        oxametacin 0
                        piroxicam + 588
                        proglumetacin + 0
                        proglumetacin dimaleate 0
                        salicin + 2
                        sodium meclofenamate monohydrate 0
                        sulindac + 785
                        suprofen 3
                        tenidap 2
                        tenoxicam 1
                        tepoxalin 5
                        tolfenamic acid 19
                        tolmetin 6
                        tolmetin sodium + 0
                        tolmetin sodium dihydrate 0
                        vedaprofen 0
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