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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
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Accession:CHEBI:35544 term browser browse the term
Definition:A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Synonyms:related_synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitor;   (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase inhibitors;   (PG)H synthase inhibitor;   (PG)H synthase inhibitors;   COX inhibitor;   EC 1.14.99.1 (cyclooxygenase) inhibitors;   EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors;   EC 1.14.99.1 inhibitor;   EC 1.14.99.1 inhibitors;   PG synthetase inhibitor;   PG synthetase inhibitors;   cyclooxygenase (EC 1.14.99.1) inhibitor;   cyclooxygenase inhibitor;   cyclooxygenase inhibitors;   fatty acid cyclooxygenase inhibitor;   fatty acid cyclooxygenase inhibitors;   prostaglandin G/H synthase inhibitor;   prostaglandin G/H synthase inhibitors;   prostaglandin endoperoxide synthetase inhibitor;   prostaglandin endoperoxide synthetase inhibitors;   prostaglandin synthase inhibitor;   prostaglandin synthase inhibitors;   prostaglandin synthetase inhibitor;   prostaglandin synthetase inhibitors


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  CHEBI ontology 19792
    role 19738
      biological role 19737
        biochemical role 19241
          enzyme inhibitor 18163
            EC 1.* (oxidoreductase) inhibitor 16526
              EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 14225
                EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor 12523
                  EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor 12523
                    (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
                    (6-methoxy-2-naphthyl)acetic acid 0
                    3',5'-di-O-methyltricetin + 1
                    4-(methylamino)antipyrine 0
                    4-aminoantipyrine 0
                    aceclofenac 4
                    acemetacin 1
                    aiphanol 0
                    ampiroxicam 0
                    carprofen + 0
                    clonixin 0
                    clonixin lysine salt 0
                    cudratricusxanthone A 0
                    cyclooxygenase 1 inhibitor + 10948
                    cyclooxygenase 2 inhibitor + 11638
                    cyclooxygenase 3 inhibitor + 10693
                    diclofenac + 997
                    flufenamic acid 42
                    flunixin 1
                    flunixin meglumine 0
                    flurbiprofen + 108
                    ibufenac 0
                    indometacin + 3161
                    indoprofen 3
                    ketoprofen 27
                    lonazolac 0
                    lonazolac calcium 0
                    loxoprofen + 3
                    loxoprofen sodium + 0
                    loxoprofen sodium hydrate 0
                    meclofenamic acid 11
                    mefenamic acid 33
                    naproxcinod 0
                    nitrosulindac 0
                    oxametacin 0
                    piroxicam + 584
                    proglumetacin + 0
                    proglumetacin dimaleate 0
                    salicin + 2
                    sodium meclofenamate monohydrate 0
                    sulindac + 772
                    suprofen 3
                    tenidap 2
                    tenoxicam 1
                    tepoxalin 5
                    tolfenamic acid 18
                    tolmetin 6
                    tolmetin sodium + 0
                    tolmetin sodium dihydrate 0
                    vedaprofen 0
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