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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5beta-cardanolide
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Accession:CHEBI:35542 term browser browse the term
Definition:A cardanolide that has formula C23H36O2.
Synonyms:related_synonym: Formula=C23H36O2;   InChI=1S/C23H36O2/c1-22-11-4-3-5-16(22)6-7-17-19-9-8-18(15-13-21(24)25-14-15)23(19,2)12-10-20(17)22/h15-20H,3-14H2,1-2H3/t15-,16-,17-,18+,19+,20-,22-,23+/m0/s1;   InChIKey=AQARKTASOBROAE-KPSWSRIPSA-N;   SMILES=[H][C@]1(COC(=O)C1)[C@@]1([H])CC[C@]2([H])[C@]3([H])CC[C@]4([H])CCCC[C@]4(C)[C@@]3([H])CC[C@]12C

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digitoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO Digitoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 decreases expression ISO Digitoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683 		JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 decreases expression ISO Digitoxigenin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 decreases expression ISO Digitoxigenin results in decreased expression of CXCL8 protein CTD PMID:20116850 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression ISO Digitoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digitoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
digitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
increases transport		 ISO Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin		 CTD PMID:23104431 PMID:26708294 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Ar androgen receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein CTD PMID:22037315 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743 		JBrowse link
G Casp3 caspase 3 decreases expression ISO Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein CTD PMID:22037315 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein CTD PMID:22037315 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 increases cleavage ISO Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein CTD PMID:22037315 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] CTD PMID:19446813 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression		 ISO Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein		 CTD PMID:22037315 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions		 ISO Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]		 CTD PMID:22037315 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) decreases expression ISO Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein CTD PMID:22037315 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein CTD PMID:22037315 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065 		JBrowse link
G Chek2 checkpoint kinase 2 decreases expression ISO Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein CTD PMID:22037315 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 decreases secretion ISO Digitoxin results in decreased secretion of CXCL8 protein CTD PMID:15136726 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein CTD PMID:22037315 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO Digitoxin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259 		JBrowse link
G Fancd2 Fanconi anemia, complementation group D2 multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 6:113,531,640...113,597,020
Ensembl chr 6:113,531,682...113,597,017 		JBrowse link
G Fanci Fanconi anemia, complementation group I multiple interactions ISO Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr 7:79,392,312...79,450,266
Ensembl chr 7:79,391,929...79,450,264 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] CTD PMID:19446813 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] CTD PMID:19446813 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] CTD PMID:19446813 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases phosphorylation ISO Digitoxin results in decreased phosphorylation of NFKBIA protein CTD PMID:15136726 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
increases activity		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] CTD PMID:19446813 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Digitoxin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Digitoxin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,740,776...98,769,006
Ensembl chr11:98,740,638...98,769,006 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Digitoxin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr14:17,659,225...18,040,097
Ensembl chr14:17,660,261...18,038,090 		JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein CTD PMID:22037315 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688 		JBrowse link
digoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases transport ISO ABCB1 protein results in increased transport of Digoxigenin CTD PMID:26708294 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 decreases expression ISO Digoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 decreases expression ISO Digoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr11:83,648,624...83,664,683
Ensembl chr11:83,662,584...83,664,683 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 decreases expression ISO Digoxigenin results in decreased expression of CXCL8 protein CTD PMID:20116850 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G G6pc glucose-6-phosphatase, catalytic multiple interactions
increases expression		 ISO Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]
Digoxigenin results in increased expression of G6PC1 mRNA		 CTD PMID:29981919 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Digoxigenin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO Digoxigenin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 1:20,777,146...20,785,274
Ensembl chr 1:20,777,146...20,790,617 		JBrowse link
G Il6ra interleukin 6 receptor, alpha decreases expression ISO Digoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196 		JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions
increases expression		 ISO Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]
Digoxigenin results in increased expression of NPAS2 mRNA		 CTD PMID:29981919 NCBI chr 1:39,193,702...39,363,240
Ensembl chr 1:39,193,731...39,363,236 		JBrowse link
G Rorc RAR-related orphan receptor gamma multiple interactions
increases expression		 ISO Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA] CTD PMID:29981919 NCBI chr 3:94,372,794...94,398,276
Ensembl chr 3:94,372,794...94,398,276 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Digoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Cxcr1 chemokine (C-X-C motif) receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 1:74,191,785...74,194,708
Ensembl chr 1:74,191,785...74,194,631 		JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246 		JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293 		JBrowse link
strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases transport ISO ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G G6pc glucose-6-phosphatase, catalytic increases expression
multiple interactions		 ISO Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]		 CTD PMID:29981919 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496 		JBrowse link
G Il17f interleukin 17F multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 1:20,777,146...20,785,274
Ensembl chr 1:20,777,146...20,790,617 		JBrowse link
G Npas2 neuronal PAS domain protein 2 multiple interactions
increases expression		 ISO Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
Strophanthidin results in increased expression of NPAS2 mRNA		 CTD PMID:29981919 NCBI chr 1:39,193,702...39,363,240
Ensembl chr 1:39,193,731...39,363,236 		JBrowse link
G Rorc RAR-related orphan receptor gamma increases expression
multiple interactions		 ISO Strophanthidin results in increased expression of RORC mRNA
RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]		 CTD PMID:29981919 NCBI chr 3:94,372,794...94,398,276
Ensembl chr 3:94,372,794...94,398,276 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21560
    chemical entity 21558
      atom 21546
        nonmetal atom 21426
          carbon atom 21135
            organic molecular entity 21135
              lipid 17891
                steroid 13054
                  steroid lactone 409
                    cardanolide 42
                      5beta-cardanolide 42
                        3-epi-digoxigenin 0
                        adonitoxigenin + 0
                        antiogenin + 0
                        bipindogenin + 0
                        cannogenin + 0
                        cardanolide glycoside + 0
                        diginatigenin + 0
                        digitoxigenin + 34
                        digoxigenin + 11
                        gitoxigenin + 5
                        ouabagenin + 0
                        sarmentogenin + 0
                        sarmentologenin + 0
                        strophanthidin + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 21560
    subatomic particle 21546
      composite particle 21546
        hadron 21546
          baryon 21546
            nucleon 21546
              atomic nucleus 21546
                atom 21546
                  main group element atom 21449
                    p-block element atom 21449
                      carbon group element atom 21240
                        carbon atom 21135
                          organic molecular entity 21135
                            organic group 19569
                              organic divalent group 19559
                                organodiyl group 19559
                                  carbonyl group 19540
                                    carbonyl compound 19540
                                      carboxylic ester 14695
                                        lactone 6049
                                          steroid lactone 409
                                            cardanolide 42
                                              5beta-cardanolide 42
                                                3-epi-digoxigenin 0
                                                adonitoxigenin + 0
                                                antiogenin + 0
                                                bipindogenin + 0
                                                cannogenin + 0
                                                cardanolide glycoside + 0
                                                diginatigenin + 0
                                                digitoxigenin + 34
                                                digoxigenin + 11
                                                gitoxigenin + 5
                                                ouabagenin + 0
                                                sarmentogenin + 0
                                                sarmentologenin + 0
                                                strophanthidin + 6
paths to the root