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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5beta-cardanolide
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Accession:CHEBI:35542 term browser browse the term
Definition:A cardanolide that has formula C23H36O2.
Synonyms:related_synonym: Formula=C23H36O2;   InChI=1S/C23H36O2/c1-22-11-4-3-5-16(22)6-7-17-19-9-8-18(15-13-21(24)25-14-15)23(19,2)12-10-20(17)22/h15-20H,3-14H2,1-2H3/t15-,16-,17-,18+,19+,20-,22-,23+/m0/s1;   InChIKey=AQARKTASOBROAE-KPSWSRIPSA-N;   SMILES=[H][C@]1(COC(=O)C1)[C@@]1([H])CC[C@]2([H])[C@]3([H])CC[C@]4([H])CCCC[C@]4(C)[C@@]3([H])CC[C@]12C

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digitoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP Digitoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 decreases expression EXP Digitoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 decreases expression EXP Digitoxigenin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP Digitoxigenin results in decreased expression of CXCL8 protein CTD PMID:20116850 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716 		JBrowse link
G IL6R interleukin 6 receptor decreases expression EXP Digitoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression EXP Digitoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
digitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases transport		 EXP Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein results in increased transport of Digitoxin		 CTD PMID:23104431 PMID:26708294 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G AR androgen receptor multiple interactions EXP Digitoxin binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP Digitoxin analog results in decreased expression of BIRC5 protein; Digitoxin results in decreased expression of BIRC5 protein CTD PMID:22037315 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CASP3 caspase 3 decreases expression EXP Digitoxin analog results in decreased expression of CASP3 protein; Digitoxin results in decreased expression of CASP3 protein CTD PMID:22037315 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP8 caspase 8 increases cleavage EXP Digitoxin analog results in increased cleavage of CASP8 protein; Digitoxin results in increased cleavage of CASP8 protein CTD PMID:22037315 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711 		JBrowse link
G CASP9 caspase 9 increases cleavage EXP Digitoxin analog results in increased cleavage of CASP9 protein; Digitoxin results in increased cleavage of CASP9 protein CTD PMID:22037315 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] CTD PMID:19446813 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203 		JBrowse link
G CCNB1 cyclin B1 multiple interactions
decreases expression		 EXP Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]
Digitoxin analog results in decreased expression of CCNB1 protein; Digitoxin results in decreased expression of CCNB1 protein		 CTD PMID:22037315 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression
multiple interactions		 EXP Digitoxin analog results in decreased expression of CDK1 protein; Digitoxin results in decreased expression of CDK1 protein
Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein]		 CTD PMID:22037315 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression EXP Digitoxin analog results in decreased expression of CDKN1A protein; Digitoxin results in decreased expression of CDKN1A protein CTD PMID:22037315 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B decreases expression EXP Digitoxin analog results in decreased expression of CDKN1B protein; Digitoxin results in decreased expression of CDKN1B protein CTD PMID:22037315 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369 		JBrowse link
G CHEK1 checkpoint kinase 1 decreases expression EXP Digitoxin analog results in decreased expression of CHEK1 protein; Digitoxin results in decreased expression of CHEK1 protein CTD PMID:22037315 NCBI chr11:125,624,910...125,676,255
Ensembl chr11:125,625,665...125,676,255 		JBrowse link
G CHEK2 checkpoint kinase 2 decreases expression EXP Digitoxin analog results in decreased expression of CHEK2 protein; Digitoxin results in decreased expression of CHEK2 protein CTD PMID:22037315 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases secretion EXP Digitoxin results in decreased secretion of CXCL8 protein CTD PMID:15136726 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716 		JBrowse link
G CYCS cytochrome c, somatic increases expression EXP Digitoxin analog results in increased expression of CYCS protein; Digitoxin results in increased expression of CYCS protein CTD PMID:22037315 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Digitoxin binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP Digitoxin binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FANCD2 FA complementation group D2 multiple interactions EXP Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein] CTD PMID:24124520 NCBI chr 3:10,026,437...10,101,932
Ensembl chr 3:10,026,414...10,101,932
Ensembl chr 3:10,026,414...10,101,932 		JBrowse link
G FANCI FA complementation group I multiple interactions EXP Digitoxin inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] CTD PMID:24124520 NCBI chr15:89,243,973...89,317,259
Ensembl chr15:89,243,945...89,317,261
Ensembl chr15:89,243,945...89,317,261 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] CTD PMID:19446813 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] CTD PMID:19446813 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] CTD PMID:19446813 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha decreases phosphorylation EXP Digitoxin results in decreased phosphorylation of NFKBIA protein CTD PMID:15136726 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases activity		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] CTD PMID:19446813 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G PGR progesterone receptor multiple interactions EXP Digitoxin binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions EXP Digitoxin binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G THRB thyroid hormone receptor beta multiple interactions EXP Digitoxin binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
G TP53 tumor protein p53 decreases expression EXP Digitoxin analog results in decreased expression of TP53 protein; Digitoxin results in decreased expression of TP53 protein CTD PMID:22037315 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19446813 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
digoxigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases transport EXP ABCB1 protein results in increased transport of Digoxigenin CTD PMID:26708294 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP Digoxigenin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 decreases expression EXP Digoxigenin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 decreases expression EXP Digoxigenin results in decreased expression of CXCL8 protein CTD PMID:20116850 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases expression		 EXP Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]
Digoxigenin results in increased expression of G6PC1 mRNA		 CTD PMID:29981919 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G IL17A interleukin 17A multiple interactions EXP Digoxigenin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL17F interleukin 17F multiple interactions EXP Digoxigenin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,244,500
Ensembl chr 6:52,236,681...52,244,500 		JBrowse link
G IL6R interleukin 6 receptor decreases expression EXP Digoxigenin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G NPAS2 neuronal PAS domain protein 2 multiple interactions
increases expression		 EXP Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]
Digoxigenin results in increased expression of NPAS2 mRNA		 CTD PMID:29981919 NCBI chr 2:100,820,139...100,996,829
Ensembl chr 2:100,820,139...100,996,829 		JBrowse link
G RORC RAR related orphan receptor C multiple interactions
increases expression		 EXP Digoxigenin promotes the reaction [RORC protein binds to G6PC1 promoter]; Digoxigenin promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [Digoxigenin results in increased expression of RORC mRNA] CTD PMID:29981919 NCBI chr 1:151,806,071...151,832,451
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression EXP Digoxigenin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509 		JBrowse link
G CASP8 caspase 8 increases activity EXP oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711 		JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 increases expression EXP oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 increases expression EXP oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 2:218,125,294...218,137,253
Ensembl chr 2:218,125,289...218,137,251 		JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 increases expression EXP oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149
Ensembl chr 2:136,114,349...136,118,149 		JBrowse link
strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases transport EXP ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions		 EXP Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]		 CTD PMID:29981919 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G IL17A interleukin 17A multiple interactions EXP Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL17F interleukin 17F multiple interactions EXP Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 6:52,236,681...52,245,689
Ensembl chr 6:52,236,681...52,244,500
Ensembl chr 6:52,236,681...52,244,500 		JBrowse link
G NPAS2 neuronal PAS domain protein 2 increases expression
multiple interactions		 EXP Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]		 CTD PMID:29981919 NCBI chr 2:100,820,139...100,996,829
Ensembl chr 2:100,820,139...100,996,829 		JBrowse link
G RORC RAR related orphan receptor C increases expression
multiple interactions		 EXP Strophanthidin results in increased expression of RORC mRNA
RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]		 CTD PMID:29981919 NCBI chr 1:151,806,071...151,832,451
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24372
    chemical entity 24340
      atom 24329
        nonmetal atom 24034
          carbon atom 23912
            organic molecular entity 23912
              lipid 19817
                steroid 13537
                  steroid lactone 403
                    cardanolide 42
                      5beta-cardanolide 42
                        3-epi-digoxigenin 0
                        adonitoxigenin + 0
                        antiogenin + 0
                        bipindogenin + 0
                        cannogenin + 0
                        cardanolide glycoside + 0
                        diginatigenin + 0
                        digitoxigenin + 34
                        digoxigenin + 11
                        gitoxigenin + 5
                        ouabagenin + 0
                        sarmentogenin + 0
                        sarmentologenin + 0
                        strophanthidin + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 24372
    subatomic particle 24329
      composite particle 24329
        hadron 24329
          baryon 24329
            nucleon 24329
              atomic nucleus 24329
                atom 24329
                  main group element atom 24177
                    p-block element atom 24177
                      carbon group element atom 23954
                        carbon atom 23912
                          organic molecular entity 23912
                            organic group 22192
                              organic divalent group 22166
                                organodiyl group 22166
                                  carbonyl group 22149
                                    carbonyl compound 22149
                                      carboxylic ester 15275
                                        lactone 6210
                                          steroid lactone 403
                                            cardanolide 42
                                              5beta-cardanolide 42
                                                3-epi-digoxigenin 0
                                                adonitoxigenin + 0
                                                antiogenin + 0
                                                bipindogenin + 0
                                                cannogenin + 0
                                                cardanolide glycoside + 0
                                                diginatigenin + 0
                                                digitoxigenin + 34
                                                digoxigenin + 11
                                                gitoxigenin + 5
                                                ouabagenin + 0
                                                sarmentogenin + 0
                                                sarmentologenin + 0
                                                strophanthidin + 6
paths to the root