CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 5alpha-spirostan
Accession: CHEBI:35538
browse the term
Definition: A spirostan that has formula C27H44O2.
Synonyms: related_synonym: Formula=C27H44O2; InChI=1S/C27H44O2/c1-17-10-14-27(28-16-17)18(2)24-23(29-27)15-22-20-9-8-19-7-5-6-12-25(19,3)21(20)11-13-26(22,24)4/h17-24H,5-16H2,1-4H3/t17?,18-,19+,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1; InChIKey=INLFWQCRAJUDCR-JCKOLVSCSA-N; SMILES=[H][C@]12CCCC[C@]1(C)[C@@]1([H])CC[C@@]3(C)[C@@]([H])(C[C@]4([H])O[C@]5(CCC(C)CO5)[C@@H](C)[C@]34[H])[C@]1([H])CC2
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Ccnb1
cyclin B1
increases expression
ISO
Digitonin results in increased expression of CCNB1 protein
CTD
PMID:36030841
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnd1
cyclin D1
increases expression
ISO
Digitonin results in increased expression of CCND1 protein
CTD
PMID:36030841
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdh5
cadherin 5
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]
CTD
PMID:31404653
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
Digitonin results in decreased expression of CDKN1A protein
CTD
PMID:36030841
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
decreases expression
ISO
Digitonin results in decreased expression of CDKN1B protein
CTD
PMID:36030841
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
Digitonin results in increased expression of CYP2B10 protein
CTD
PMID:36030841
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Etv2
ETS variant transcription factor 2
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]
CTD
PMID:31404653
NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431
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Gata2
GATA binding protein 2
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]
CTD
PMID:31404653
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression
ISO
Digitonin results in decreased expression of HIF1A protein
CTD
PMID:34717917
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Nek2
NIMA-related kinase 2
increases expression
ISO
Digitonin results in increased expression of NEK2 protein
CTD
PMID:36030841
NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
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Rbl2
RB transcriptional corepressor like 2
decreases expression
ISO
Digitonin results in decreased expression of RBL2 protein
CTD
PMID:36030841
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slco1a4
solute carrier organic anion transporter family, member 1a4
increases expression
ISO
Digitonin results in increased expression of SLCO1A4 protein
CTD
PMID:36030841
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Spn
sialophorin
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]
CTD
PMID:31404653
NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
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