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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sympathomimetic agent
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Accession:CHEBI:35524 term browser browse the term
Definition:A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Synonyms:related_synonym: sympathomimetic;   sympathomimetics


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(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A affects abundance EXP NPPA protein affects the abundance of Epinephrine CTD PMID:2951327 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 increases activity EXP Norepinephrine results in increased activity of ADRB1 protein CTD PMID:10344530 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Norepinephrine results in increased expression of NPPA protein CTD PMID:8952593 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G POMC proopiomelanocortin increases response to substance EXP POMC protein results in increased susceptibility to Norepinephrine CTD PMID:6279499 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin increases activity EXP Norepinephrine results in increased activity of REN protein CTD PMID:8952593 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
isoprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions
increases activity		 EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A multiple interactions EXP Phenylephrine binds to and results in increased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:19371927 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486 		JBrowse link
G ADRA1D adrenoceptor alpha 1D multiple interactions EXP BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; Phenylephrine binds to and results in increased activity of ADRA1D protein CTD PMID:19371927 NCBI chr24:17,231,771...17,239,110
Ensembl chr24:17,213,643...17,214,761
Ensembl chr24:17,213,643...17,214,761 		JBrowse link
G REN renin increases secretion EXP Phenylephrine results in increased secretion of REN protein CTD PMID:6347479 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 494
    role 501
      biological role 494
        pharmacological role 164
          neurotransmitter agent 99
            adrenergic agent 28
              sympathomimetic agent 9
                (-)-ephedrine 0
                (R)-adrenaline + 1
                (R)-noradrenaline + 7
                (S)-amphetamine + 0
                L-isoprenaline 0
                acebutolol 0
                acebutolol hydrochloride 0
                amezinium + 0
                amezinium metilsulfate 0
                amphetamine + 0
                bambuterol + 0
                bambuterol hydrochloride + 0
                benzphetamine + 0
                benzphetamine hydrochloride 0
                clenbuterol + 0
                clenbuterol hydrochloride + 0
                clorprenaline 0
                cocaine 0
                deglymidodrine + 0
                diazoxide 0
                dipivefrin 0
                dipivefrin hydrochloride 0
                dobutamine + 0
                dobutamine hydrochloride 0
                dopamine + 0
                fenoterol + 0
                fenoterol hydrobromide 0
                isoprenaline 1
                metaraminol 0
                methylphenidate 0
                midodrine 0
                midodrine hydrochloride 0
                oxymetazoline 0
                oxymetazoline hydrochloride 0
                phenmetrazine 0
                phentermine + 0
                phenylephrine 3
                phenylpropanolamine 0
                pseudoephedrine 0
                terbutaline + 0
                tetrahydrozoline hydrochloride 0
                tetrahydrozoline nitrate 0
                tetryzoline 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 494
    role 501
      application 452
        pharmaceutical 453
          drug 446
            neurotransmitter agent 99
              adrenergic agent 28
                sympathomimetic agent 9
                  (-)-ephedrine 0
                  (R)-adrenaline + 1
                  (R)-noradrenaline + 7
                  (S)-amphetamine + 0
                  L-isoprenaline 0
                  acebutolol 0
                  acebutolol hydrochloride 0
                  amezinium + 0
                  amezinium metilsulfate 0
                  amphetamine + 0
                  bambuterol + 0
                  bambuterol hydrochloride + 0
                  benzphetamine + 0
                  benzphetamine hydrochloride 0
                  clenbuterol + 0
                  clenbuterol hydrochloride + 0
                  clorprenaline 0
                  cocaine 0
                  deglymidodrine + 0
                  diazoxide 0
                  dipivefrin 0
                  dipivefrin hydrochloride 0
                  dobutamine + 0
                  dobutamine hydrochloride 0
                  dopamine + 0
                  fenoterol + 0
                  fenoterol hydrobromide 0
                  isoprenaline 1
                  metaraminol 0
                  methylphenidate 0
                  midodrine 0
                  midodrine hydrochloride 0
                  oxymetazoline 0
                  oxymetazoline hydrochloride 0
                  phenmetrazine 0
                  phentermine + 0
                  phenylephrine 3
                  phenylpropanolamine 0
                  pseudoephedrine 0
                  terbutaline + 0
                  tetrahydrozoline hydrochloride 0
                  tetrahydrozoline nitrate 0
                  tetryzoline 0
paths to the root