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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-adrenergic agonist
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Accession:CHEBI:35522 term browser browse the term
Definition:An agent that selectively binds to and activates beta-adrenergic receptors.
Synonyms:related_synonym: beta-adrenergic agonists;   beta-adrenergic receptor agonist;   beta-adrenoceptor agonists


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(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases export
EXP [Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite
ABCC1 protein results in increased export of Epinephrine metabolite
CTD PMID:19053318 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Aco2 aconitase 2 increases expression EXP Epinephrine results in increased expression of ACO2 protein CTD PMID:19464573 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Actn1 actinin, alpha 1 increases expression EXP Epinephrine results in increased expression of ACTN1 protein CTD PMID:19464573 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
increases activity
affects binding
EXP
ISO
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; Epinephrine binds to and results in increased activity of ADRA1A protein
Epinephrine results in increased activity of ADRA1A protein
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1A protein; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
Epinephrine binds to ADRA1A protein
CTD PMID:8183249 PMID:15306222 PMID:15672411 PMID:20030735 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
increases activity
ISO [Epinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1B protein; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] CTD PMID:15306222 PMID:20030735 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
increases activity
multiple interactions
ISO Epinephrine binds to ADRA1D protein
Epinephrine results in increased activity of ADRA1D protein
[Epinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1D protein; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]
CTD PMID:8183249 PMID:15306222 PMID:20030735 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A increases activity
multiple interactions
EXP
ISO
Epinephrine results in increased activity of ADRA2A protein
Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein]
[Epinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2A protein; Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]
CTD PMID:17341653 PMID:17680988 PMID:20030735 PMID:30737458 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2B protein; Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:17680988 PMID:20030735 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2C protein; Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan] CTD PMID:17680988 PMID:20030735 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP
[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine
Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB1 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
CTD PMID:8096834 PMID:12010770 PMID:14730417 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects response to substance
increases activity
ISO
EXP
[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Epinephrine binds to and results in increased activity of ADRB2 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein; ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]
[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine
ADRB2 affects the susceptibility to Epinephrine
CTD PMID:1389726 PMID:11164953 PMID:12920204 PMID:14722251 PMID:14730417 PMID:16026475 PMID:16225854 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP
ISO
Epinephrine binds to and results in increased activity of ADRB3 protein
[Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB3 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]
CTD PMID:1682311 PMID:7815362 PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ak2 adenylate kinase 2 decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of AK2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein
CTD PMID:19464573 NCBI chr 5:147,185,474...147,204,050
Ensembl chr 5:147,185,474...147,204,050
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein CTD PMID:32305330 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions
increases activity
EXP Cycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Aqp7 aquaporin 7 affects localization
multiple interactions
increases expression
ISO Epinephrine affects the localization of AQP7 protein
INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]
CTD PMID:10777495 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP Epinephrine results in increased expression of ATP5F1A protein CTD PMID:19464573 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression ISO Epinephrine results in decreased expression of BMP2 mRNA; Epinephrine results in decreased expression of BMP2 protein CTD PMID:31520687 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G C1qbp complement C1q binding protein multiple interactions
increases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein
Epinephrine results in increased expression of C1QBP protein
CTD PMID:19464573 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Calca calcitonin-related polypeptide alpha increases abundance EXP CALCA protein results in increased abundance of Epinephrine CTD PMID:8058111 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Caly calcyon neuron-specific vesicular protein decreases secretion ISO CALY protein results in decreased secretion of Epinephrine CTD PMID:30753204 NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Epinephrine results in increased expression of CA2 mRNA CTD PMID:12729923 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]; carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]
CTD PMID:10728402 PMID:19135123 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases response to substance ISO CAT results in decreased susceptibility to Epinephrine CTD PMID:25172298 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]; Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]]
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Epinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]
CTD PMID:9863660 PMID:12538206 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]
Epinephrine results in increased expression of CCND1 mRNA; Epinephrine results in increased expression of CCND1 protein
ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]
CTD PMID:17680988 PMID:26964897 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Epinephrine results in decreased expression of CEBPB protein CTD PMID:31520687 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] CTD PMID:17498763 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Comt catechol-O-methyltransferase increases methylation
multiple interactions
ISO
EXP
COMT protein results in increased methylation of Epinephrine
[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine
CTD PMID:8821542 PMID:10064789 PMID:11160877 PMID:11248589 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
ISO
EXP
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988 PMID:22496244 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases abundance
EXP corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine]
CRH results in increased abundance of Epinephrine
CTD PMID:1320258 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]] CTD PMID:1699227 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation
multiple interactions
EXP Epinephrine results in increased phosphorylation of CTNNB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]
CTD PMID:26964897 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctsk cathepsin K increases expression ISO Epinephrine results in increased expression of CTSK mRNA CTD PMID:12729923 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein
Epinephrine results in increased expression of CYCS protein
CTD PMID:19464573 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dbh dopamine beta-hydroxylase affects abundance ISO DBH gene polymorphism affects the abundance of Epinephrine CTD PMID:16163519 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Des desmin multiple interactions
decreases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein
Epinephrine results in decreased expression of DES protein
CTD PMID:19464573 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein CTD PMID:19464573 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein CTD PMID:19464573 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Epha4 Eph receptor A4 increases phosphorylation ISO Epinephrine results in increased phosphorylation of EPHA4 protein CTD PMID:22273509 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Etfb electron transfer flavoprotein subunit beta multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein CTD PMID:19464573 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976
JBrowse link
G Fabp3 fatty acid binding protein 3 affects expression
multiple interactions
EXP Epinephrine affects the expression of FABP3 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein
CTD PMID:19464573 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fh fumarate hydratase increases expression EXP Epinephrine results in increased expression of FH protein CTD PMID:19464573 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377
JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Epinephrine results in decreased expression of FOXO1 protein CTD PMID:31520687 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gnb2 G protein subunit beta 2 multiple interactions ISO Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096
JBrowse link
G Gnb4 G protein subunit beta 4 multiple interactions ISO Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 2:118,978,965...119,007,877
Ensembl chr 2:118,978,973...119,007,835
JBrowse link
G Gng12 G protein subunit gamma 12 multiple interactions ISO Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102
JBrowse link
G Gng2 G protein subunit gamma 2 multiple interactions ISO Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr15:4,748,242...4,853,555
Ensembl chr15:4,850,122...4,853,555
JBrowse link
G Gng3 G protein subunit gamma 3 multiple interactions ISO Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 1:225,033,921...225,035,687
Ensembl chr 1:225,033,921...225,035,687
JBrowse link
G Gng4 G protein subunit gamma 4 multiple interactions ISO Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr17:90,266,571...90,316,278
Ensembl chr17:90,266,794...90,315,492
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions ISO Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 multiple interactions ISO Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein CTD PMID:19464573 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
affects localization
EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]
Epinephrine affects the localization of HSF1 protein
CTD PMID:19135123 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein CTD PMID:19464573 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein CTD PMID:19464573 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Epinephrine results in increased expression of HSPA8 protein CTD PMID:19464573 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein CTD PMID:19464573 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of HSPB6 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein
CTD PMID:19464573 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of IDH2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein
CTD PMID:19464573 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Epinephrine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:10588509 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10588509 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
EXP
ISO
Epinephrine results in decreased expression of IL6 mRNA
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:10588509 PMID:12423672 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein]; Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] CTD PMID:1218171 PMID:6018752 PMID:6314140 PMID:32305330 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine] CTD PMID:16214444 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Epinephrine results in increased expression of ITGAV mRNA CTD PMID:12729923 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance EXP ITGB1 results in increased susceptibility to Epinephrine CTD PMID:14984413 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases expression
affects localization
increases activity
ISO
EXP
Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]
Epinephrine results in increased expression of LIPE mRNA
Epinephrine affects the localization of LIPE protein
CTD PMID:7155675 PMID:10777495 PMID:11160373 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
affects activity
ISO
EXP
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]
Epinephrine deficiency results in increased activity of MAPK1 protein
Epinephrine affects the activity of MAPK1 protein
CTD PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
affects activity
ISO
EXP
ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]
Epinephrine deficiency results in increased activity of MAPK3 protein
Epinephrine affects the activity of MAPK3 protein
CTD PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Meis1 Meis homeobox 1 decreases expression ISO Epinephrine results in decreased expression of MEIS1 protein CTD PMID:31520687 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Myl2 myosin light chain 2 multiple interactions
affects expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein
Epinephrine affects the expression of MYL2 protein
CTD PMID:19464573 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Epinephrine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Epinephrine results in increased expression of NOS2 mRNA
CTD PMID:16925470 PMID:19439816 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Epinephrine results in increased expression of NTF3 mRNA; Epinephrine results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases activity ISO Epinephrine results in decreased activity of P2RX7 protein CTD PMID:15459114 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions ISO Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate] CTD PMID:11413167 NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548
JBrowse link
G Phb prohibitin multiple interactions
increases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein
Epinephrine results in increased expression of PHB protein
CTD PMID:19464573 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Epinephrine results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein CTD PMID:19464573 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Epinephrine results in increased expression of PPARGC1A mRNA CTD PMID:22496244 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression
multiple interactions
EXP Epinephrine results in decreased expression of PPP2R1A protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein
CTD PMID:19464573 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression
EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein
Epinephrine results in decreased expression of PRDX6 protein
CTD PMID:19464573 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Prkce protein kinase C, epsilon affects response to substance ISO
EXP
PRKCE protein affects the susceptibility to Epinephrine CTD PMID:11454025 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Epinephrine results in decreased expression of PTGS2 mRNA; Epinephrine results in decreased expression of PTGS2 protein CTD PMID:31520687 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions
increases activity
ISO ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] CTD PMID:6314140 PMID:8592096 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Sct secretin multiple interactions EXP Epinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP] CTD PMID:6312992 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Epinephrine results in increased expression of SERPINE1 mRNA CTD PMID:15850565 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake
EXP
ISO
[Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine
SLC22A3 protein results in increased uptake of Epinephrine
CTD PMID:19053318 PMID:20858707 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Epinephrine CTD PMID:20858707 NCBI chr12:13,914,114...13,924,511
Ensembl chr12:13,914,114...13,924,531
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects binding
increases expression
increases activity
ISO
EXP
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Epinephrine binds to SOD1 protein mutant form
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 mRNA; Epinephrine results in increased expression of SOD1 protein
CTD PMID:11163531 PMID:19464573 PMID:23612299 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity
ISO
EXP
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 mRNA; Epinephrine results in increased expression of SOD2 protein
CTD PMID:11163531 PMID:19464573 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP Epinephrine results in increased expression of SUCLG2 protein CTD PMID:19464573 NCBI chr 4:127,552,100...127,824,970
Ensembl chr 4:127,552,101...127,824,970
JBrowse link
G Th tyrosine hydroxylase increases chemical synthesis
multiple interactions
ISO
EXP
TH protein results in increased chemical synthesis of Epinephrine
[Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine
CTD PMID:9822156 PMID:19067675 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions
decreases expression
ISO Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1] CTD PMID:7558147 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases secretion
ISO
EXP
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Epinephrine results in decreased expression of TNF mRNA
Epinephrine results in decreased secretion of TNF protein
CTD PMID:10588509 PMID:12423672 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions
EXP Epinephrine results in increased expression of VDAC1 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein
CTD PMID:19464573 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Wnt4 Wnt family member 4 decreases expression ISO Epinephrine results in decreased expression of WNT4 mRNA; Epinephrine results in decreased expression of WNT4 protein CTD PMID:31520687 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein] CTD PMID:19135123 PMID:19464573 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
albuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP
Albuterol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Albuterol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein] CTD PMID:8096834 PMID:14730417 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 decreases response to substance
increases activity
multiple interactions
increases phosphorylation
decreases expression
ISO
EXP
ADRB2 gene polymorphism results in decreased susceptibility to Albuterol
Albuterol results in increased activity of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Albuterol binds to and results in increased activity of ADRB2 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]
Albuterol results in increased phosphorylation of ADRB2 protein
Albuterol results in decreased expression of ADRB2 protein
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid; Albuterol binds to and results in increased activity of ADRB2 protein
CTD PMID:2463453 PMID:8102213 PMID:8937731 PMID:10516654 PMID:10952688 PMID:12920204 PMID:14722251 PMID:14730417 PMID:15467267 PMID:15687340 PMID:16980553 PMID:19120125 PMID:19363516 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [Albuterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Albuterol binds to and results in increased activity of ADRB3 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Albuterol results in increased expression of BAX CTD PMID:11802967 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Albuterol results in decreased expression of BCL2 CTD PMID:11802967 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol] CTD PMID:19462961 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] CTD PMID:12818968 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein CTD PMID:15679717 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Albuterol results in increased expression of CDK2 protein CTD PMID:18362475 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression ISO Albuterol results in increased expression of CDK4 protein CTD PMID:18362475 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Ckm creatine kinase, M-type increases secretion ISO Albuterol results in increased secretion of CKM protein CTD PMID:8970440 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein CTD PMID:15679717 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Albuterol results in increased expression of CYP17A1 CTD PMID:17822730 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [Cyproterone co-treated with Albuterol] results in decreased expression of CYP19A1 CTD PMID:17822730 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Albuterol results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Il10 interleukin 10 decreases expression EXP Albuterol results in decreased expression of IL10 mRNA CTD PMID:16908771 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Albuterol results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Albuterol results in decreased expression of IL1B mRNA
CTD PMID:11112151 PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il24 interleukin 24 increases expression ISO Albuterol results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO 1-Methyl-3-isobutylxanthine promotes the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]]; Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]; ICI 118551 inhibits the reaction [Albuterol inhibits the reaction [IL5 protein results in increased abundance of Superoxides]] CTD PMID:16238794 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
Albuterol results in increased expression of IL6 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Theophylline co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Albuterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:18362475 PMID:20388727 PMID:20519841 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 increases expression ISO Albuterol results in increased expression of INS; Albuterol results in increased expression of INS protein CTD PMID:8098220 PMID:9088585 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ldlr low density lipoprotein receptor affects response to substance ISO LDLR gene SNP affects the susceptibility to Albuterol CTD PMID:15453913 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:16980553 PMID:20519841 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein
Albuterol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:16980553 PMID:20519841 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol; Ascorbic Acid inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Azide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Sodium Cyanide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol] CTD PMID:19462961 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Albuterol results in increased expression of NFKBIA protein CTD PMID:18362475 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:20519841 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein CTD PMID:15679717 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Pde4a phosphodiesterase 4A multiple interactions ISO [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNA CTD PMID:10763856 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions ISO [Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA CTD PMID:10763856 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Albuterol results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Albuterol results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Albuterol results in increased expression of PPARGC1A mRNA CTD PMID:17446185 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptafr platelet-activating factor receptor increases expression ISO Albuterol results in increased expression of PTAFR protein CTD PMID:18362475 NCBI chr 5:150,746,284...150,775,675
Ensembl chr 5:150,754,021...150,775,672
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO Albuterol promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
Albuterol results in decreased expression of PTGS2 mRNA
CTD PMID:11112151 PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression
multiple interactions
increases expression
ISO Albuterol results in decreased expression of RB1 protein
ICI 118551 inhibits the reaction [Albuterol results in decreased expression of RB1 protein]
Albuterol results in increased expression of RB1 protein
CTD PMID:16446544 PMID:18362475 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Ren renin increases expression ISO Albuterol results in increased expression of REN protein CTD PMID:2829953 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Albuterol results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
Albuterol results in decreased secretion of TNF protein
[Albuterol co-treated with Theophylline] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [Dexamethasone co-treated with Albuterol] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Albuterol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Albuterol promotes the reaction [Theophylline inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
CTD PMID:8937731 PMID:10229875 PMID:20388727 PMID:20519841 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Albuterol results in increased expression of TP53 CTD PMID:11802967 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Albuterol results in increased expression of UCP1 protein CTD PMID:10465291 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions ISO [Albuterol co-treated with acipimox] results in decreased expression of UCP3 mRNA CTD PMID:12824081 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
arbutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions EXP arbutamine binds to and results in increased activity of ADRB1 protein CTD PMID:8723169 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
bambuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO bambuterol results in decreased activity of ACHE protein CTD PMID:18582854 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO bambuterol results in decreased activity of BCHE protein CTD PMID:15652380 PMID:18582854 PMID:18977317 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
clenbuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Clenbuterol results in increased expression of ACADM mRNA CTD PMID:17446185 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO
EXP
[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose; ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose] CTD PMID:16007677 PMID:18552870 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP Clenbuterol binds to and results in increased activity of ADRB3 protein CTD PMID:7815362 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein] CTD PMID:16339297 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]] CTD PMID:15710352 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]] CTD PMID:15710352 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Clenbuterol results in increased expression of ESRRA mRNA CTD PMID:17446185 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]; Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]] CTD PMID:8774452 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression
ISO
EXP
Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Clenbuterol affects the expression of IL10 protein
CTD PMID:15021963 PMID:15502056 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 increases expression ISO Clenbuterol results in increased expression of IL18 mRNA; Clenbuterol results in increased expression of IL18 protein CTD PMID:15178407 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:15021963 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:15021963 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:15502056 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases stability
increases activity
ISO Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Propranolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]
Clenbuterol results in increased stability of ODC1 protein
CTD PMID:10353628 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Clenbuterol results in increased expression of PDK4 mRNA CTD PMID:17446185 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
Clenbuterol results in increased expression of PPARGC1A mRNA
Propranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]
CTD PMID:17446185 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] CTD PMID:16339297 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Clenbuterol affects the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15710352 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Clenbuterol results in increased expression of TFAM mRNA CTD PMID:17446185 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15021963 PMID:15710352 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Clenbuterol results in increased expression of UCP1 protein CTD PMID:10465291 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
clorprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clorprenaline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
diazoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 decreases localization
multiple interactions
EXP Diazoxide results in decreased localization of AIFM1 protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased localization of AIFM1 protein]
CTD PMID:21256120 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased phosphorylation of AKT1 protein] CTD PMID:21256120 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:20650802 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Diazoxide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:20650802 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 mRNA alternative form]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased expression of BCL2L1 protein alternative form]
Diazoxide results in increased expression of BCL2L1 mRNA alternative form; Diazoxide results in increased expression of BCL2L1 protein alternative form
CTD PMID:15326191 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
EXP 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased activity of CASP3 protein] CTD PMID:21256120 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CCND1 mRNA
CTD PMID:19052819 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO Diazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]
Diazoxide results in decreased expression of CTNNB1 protein
CTD PMID:19052819 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cycs cytochrome c, somatic decreases secretion
multiple interactions
EXP Diazoxide results in decreased secretion of CYCS protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in decreased secretion of CYCS protein]
CTD PMID:21256120 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]; zinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Gcg glucagon multiple interactions ISO Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein] CTD PMID:23200776 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 multiple interactions ISO [Potassium Chloride co-treated with Diazoxide] inhibits the reaction [[GPD2 mutant form co-treated with Aminooxyacetic Acid] inhibits the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:10464266 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 mRNA]; Diazoxide inhibits the reaction [Oxygen deficiency results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions EXP Diazoxide inhibits the reaction [Glucose results in increased expression of IAPP mRNA] CTD PMID:9142872 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Diazoxide results in decreased secretion of IL10 protein CTD PMID:16612254 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 decreases secretion ISO Diazoxide results in decreased secretion of IL6 protein CTD PMID:16612254 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 decreases expression ISO Diazoxide results in decreased expression of KCNJ11 mRNA CTD PMID:23200776 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Lep leptin multiple interactions
decreases secretion
EXP Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein]
Diazoxide results in decreased secretion of LEP protein
CTD PMID:10780946 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions ISO Diazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein] CTD PMID:23536823 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity
ISO 5-hydroxydecanoic acid inhibits the reaction [Diazoxide results in increased activity of NFKB1 protein] CTD PMID:15326191 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]]; Diazoxide inhibits the reaction [Rotenone results in increased expression of and results in increased activity of NOS2 protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]]; Diazoxide inhibits the reaction [Rotenone results in increased activity of NOS2 protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]
CTD PMID:15795934 PMID:15927086 PMID:16257489 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] CTD PMID:11527545 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions EXP Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA] CTD PMID:11527545 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
ISO
EXP
Diazoxide results in decreased secretion of TNF protein
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]]; 5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]]; Diazoxide inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; Diazoxide inhibits the reaction [Rotenone results in increased expression of TNF protein]
5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]]; Diazoxide inhibits the reaction [Rotenone results in increased secretion of TNF protein]
CTD PMID:16257489 PMID:16612254 PMID:18700057 PMID:19012619 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Diazoxide results in decreased expression of TP53 mRNA CTD PMID:16426753 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Dobutamine results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Adcy6 adenylate cyclase 6 affects response to substance ISO ADCY6 protein affects the susceptibility to Dobutamine CTD PMID:12393090 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO Dobutamine binds to and results in increased activity of ADRA2A protein CTD PMID:16024912 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adrb1 adrenoceptor beta 1 affects response to substance
multiple interactions
ISO
EXP
ADRB1 gene affects the susceptibility to Dobutamine; ADRB1 gene polymorphism affects the susceptibility to Dobutamine; ADRB1 protein polymorphism affects the susceptibility to Dobutamine
ADRB1 gene polymorphism affects the susceptibility to [Dobutamine co-treated with Metoprolol]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine binds to and results in increased activity of ADRB1 protein; Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
[Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 mRNA; [Dobutamine co-treated with ICI 118551] results in decreased expression of ADRB1 protein; Dobutamine binds to and results in increased activity of ADRB1 protein; Dobutamine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Oxygen deficiency results in increased susceptibility to [Dobutamine binds to and results in increased activity of ADRB1 protein]
CTD PMID:8096834 PMID:10192281 PMID:11753577 PMID:14502278 PMID:15564877 PMID:16024912 PMID:18787115 PMID:19719783 PMID:20821015 PMID:21311897 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance ISO ADRB2 gene polymorphism affects the susceptibility to Dobutamine CTD PMID:17094270 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 mRNA; [Dobutamine co-treated with ICI 118551] results in increased expression of ADRB3 protein CTD PMID:19719783 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Ahsg alpha-2-HS-glycoprotein affects response to substance ISO AHSG protein affects the susceptibility to Dobutamine CTD PMID:16177000 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions
ISO
EXP
AKT1 protein affects the susceptibility to Dobutamine
Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein]
CTD PMID:16094411 PMID:16339297 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]] CTD PMID:18787115 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Dobutamine results in increased expression of BAX protein CTD PMID:15052282 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Dobutamine results in decreased expression of BCL2 protein CTD PMID:15052282 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression ISO Dobutamine results in increased expression of BNIP1 protein CTD PMID:15052282 NCBI chr10:16,677,077...16,689,321
Ensembl chr10:16,677,077...16,689,321
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:12818967 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] CTD PMID:12818968 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Clu clusterin increases expression ISO Dobutamine results in increased expression of CLU protein CTD PMID:15052282 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Comt catechol-O-methyltransferase increases methylation
increases expression
ISO
EXP
COMT protein results in increased methylation of Dobutamine
Dobutamine results in increased expression of COMT mRNA
CTD PMID:11160877 PMID:12423672 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Dobutamine results in increased expression of CPT1A mRNA; Dobutamine results in increased expression of CPT1A protein CTD PMID:8479178 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crem cAMP responsive element modulator affects response to substance ISO CREM protein affects the susceptibility to Dobutamine CTD PMID:12475904 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Ctf1 cardiotrophin 1 affects response to substance ISO CTF1 protein affects the susceptibility to Dobutamine CTD PMID:17150369 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA] CTD PMID:11605937 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Dbh dopamine beta-hydroxylase affects response to substance ISO DBH protein affects the susceptibility to Dobutamine CTD PMID:10338466 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Dmd dystrophin increases response to substance ISO DMD gene mutant form results in increased susceptibility to Dobutamine CTD PMID:17440445 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Egfr epidermal growth factor receptor decreases response to substance
multiple interactions
ISO EGFR gene mutant form results in decreased susceptibility to Dobutamine
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; AG 1879 inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of and results in increased uptake of EGFR protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]; Propranolol inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]]
CTD PMID:18599591 PMID:18787115 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Dobutamine binds to and results in increased activity of ESR1 protein CTD PMID:24928891 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Dobutamine results in increased expression of F3 protein CTD PMID:16286589 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf2 fibroblast growth factor 2 affects response to substance ISO FGF2 protein affects the susceptibility to Dobutamine CTD PMID:10491406 PMID:14583313 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Dobutamine results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP GH1 protein promotes the reaction [Dobutamine results in increased metabolism of Lipids] CTD PMID:14981226 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gk glycerol kinase increases activity EXP Dobutamine results in increased activity of GK protein CTD PMID:12736183 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Gnas GNAS complex locus increases response to substance ISO GNAS gene SNP results in increased susceptibility to Dobutamine CTD PMID:19542315 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects response to substance ISO GSK3B gene mutant form affects the susceptibility to Dobutamine CTD PMID:17901358 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; HBEGF protein promotes the reaction [Dobutamine promotes the reaction [ADRB1 protein results in increased phosphorylation of EGFR protein]] CTD PMID:18787115 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP esmolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; Metoprolol inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]
Dobutamine results in increased expression of HMOX1 mRNA; Dobutamine results in increased expression of HMOX1 protein
CTD PMID:15179140 PMID:16627864 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 increases response to substance EXP IGF1 protein results in increased susceptibility to Dobutamine CTD PMID:17184500 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Dobutamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
CTD PMID:11605937 PMID:15502056 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
EXP
ISO
Dobutamine results in increased expression of IL1B mRNA
Dobutamine results in decreased expression of IL1B mRNA
CTD PMID:9387890 PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
multiple interactions
ISO
EXP
Dobutamine results in increased expression of IL6 protein
Dobutamine results in decreased expression of IL6 mRNA
Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Dobutamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:11605937 PMID:12423672 PMID:16286589 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb1 integrin subunit beta 1 affects response to substance ISO ITGB1 protein affects the susceptibility to Dobutamine CTD PMID:11884376 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]; Metoprolol inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dobutamine results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 multiple interactions
affects response to substance
ISO KCNJ11 protein affects the reaction [[Manganese co-treated with Dobutamine] results in increased abundance of Calcium]
KCNJ11 protein affects the susceptibility to Dobutamine
CTD PMID:17189350 NCBI chr 1:102,103,093...102,107,134
Ensembl chr 1:102,103,094...102,106,127
JBrowse link
G Klk1 kallikrein 1 affects response to substance ISO KLK1 protein affects the susceptibility to Dobutamine CTD PMID:12411458 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Lep leptin decreases secretion
decreases expression
ISO Dobutamine results in decreased secretion of LEP protein
Dobutamine results in decreased expression of LEP mRNA; Dobutamine results in decreased expression of LEP protein
CTD PMID:9002984 PMID:11022189 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor affects response to substance ISO LEPR protein affects the susceptibility to Dobutamine CTD PMID:20175764 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK1 protein
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]]
Dobutamine results in increased phosphorylation of MAPK1 protein
CTD PMID:16760913 PMID:18787115 PMID:19719783 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Dobutamine co-treated with ICI 118551] results in increased activity of MAPK3 protein
AG 1879 inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB1 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]; HBEGF protein inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]; RTKI cpd inhibits the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Dobutamine results in increased phosphorylation of MAPK3 protein
CTD PMID:16760913 PMID:18787115 PMID:19719783 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP [Dobutamine co-treated with ICI 118551] results in increased activity of MAPK9 protein CTD PMID:19719783 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mb myoglobin affects response to substance ISO MB protein affects the susceptibility to Dobutamine CTD PMID:10468637 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dobutamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:15502056 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos1 nitric oxide synthase 1 affects response to substance ISO NOS1 protein affects the susceptibility to Dobutamine CTD PMID:16344403 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 affects response to substance ISO NOS2 protein affects the susceptibility to Dobutamine CTD PMID:9396439 PMID:11489778 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Dobutamine results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Dobutamine results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pln phospholamban affects response to substance ISO PLN protein affects the susceptibility to Dobutamine CTD PMID:14991071 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha affects response to substance ISO PPP2CA protein affects the susceptibility to Dobutamine CTD PMID:15247211 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Dobutamine inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] CTD PMID:16339297 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkce protein kinase C, epsilon affects response to substance ISO PRKCE protein affects the susceptibility to Dobutamine CTD PMID:15242976 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prop1 PROP paired-like homeobox 1 decreases response to substance ISO PROP1 gene mutant form results in decreased susceptibility to Dobutamine CTD PMID:19414510 NCBI chr10:36,449,920...36,452,381
Ensembl chr10:36,449,920...36,452,378
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Dobutamine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
increases activity
ISO Cycloheximide inhibits the reaction [Dobutamine results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]
Dobutamine results in increased expression of REN mRNA
Dobutamine results in increased activity of REN protein
CTD PMID:9203624 PMID:9209250 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G S100a1 S100 calcium binding protein A1 increases response to substance ISO S100A1 gene mutant form results in increased susceptibility to Dobutamine CTD PMID:18645228 NCBI chr 2:189,900,505...189,905,348
Ensembl chr 2:189,900,667...189,903,219
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma increases expression EXP Dobutamine results in increased expression of SCNN1G mRNA CTD PMID:16638327 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Sgcd sarcoglycan, delta affects response to substance ISO SGCD affects the susceptibility to Dobutamine CTD PMID:20675662 NCBI chr10:32,062,946...32,471,454
Ensembl chr10:32,062,946...32,471,454
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases degradation EXP Dobutamine deficiency results in increased degradation of SPTAN1 protein CTD PMID:15849228 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO Dobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein] CTD PMID:8994422 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO Dobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein] CTD PMID:8994422 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Dobutamine results in increased expression of TGFB1 mRNA CTD PMID:16760913 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Dobutamine results in increased expression of TGFB2 mRNA CTD PMID:16760913 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor decreases expression
decreases secretion
EXP Dobutamine results in decreased expression of TNF mRNA
Dobutamine results in decreased secretion of TNF protein
CTD PMID:12423672 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Dobutamine results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [Dobutamine results in increased metabolism of Lipids]; USF1 protein affects the reaction [Dobutamine results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:89,797,750...89,805,561
Ensembl chr13:89,797,800...89,805,558
JBrowse link
G Vegfa vascular endothelial growth factor A affects response to substance ISO VEGFA protein affects the susceptibility to Dobutamine CTD PMID:11599061 PMID:14583313 PMID:19237429 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
dopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A3galt2 alpha 1,3-galactosyltransferase 2 increases expression EXP Dopamine results in increased expression of A3GALT2 mRNA CTD PMID:21983523 NCBI chr 5:146,933,592...146,945,882
Ensembl chr 5:146,933,592...146,945,880
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase decreases expression EXP Dopamine results in decreased expression of ABL2 mRNA CTD PMID:21983523 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Actb actin, beta affects expression ISO Dopamine affects the expression of ACTB protein CTD PMID:24675778 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actbl2 actin, beta-like 2 decreases expression ISO Dopamine results in decreased expression of ACTBL2 protein CTD PMID:24675778 NCBI chr 2:42,829,413...42,832,160
Ensembl chr 2:42,829,413...42,832,160
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Dopamine results in increased expression of ACTG1 mRNA CTD PMID:21983523 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression EXP Dopamine results in increased expression of ADAM9 mRNA CTD PMID:21983523 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 increases expression EXP Dopamine results in increased expression of ADAMTS4 mRNA CTD PMID:21983523 NCBI chr13:89,622,996...89,632,485
Ensembl chr13:89,622,632...89,634,419
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP [N(6)-cyclohexyladenosine binds to and results in increased activity of ADORA1 protein] promotes the reaction [Methamphetamine results in increased secretion of Dopamine] CTD PMID:11043458 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra2a adrenoceptor alpha 2A affects binding ISO Dopamine binds to ADRA2A protein CTD PMID:10336518 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding ISO Dopamine binds to ADRA2C protein CTD PMID:10336518 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions EXP [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine; ICI 118551 inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Dopamine] CTD PMID:10894789 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agt angiotensinogen multiple interactions ISO Clozapine inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]] CTD PMID:11549694 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; ALDH2 protein affects the reaction [Cocaine results in increased abundance of Dopamine] CTD PMID:20729865 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Dopamine results in increased expression of ALDOA protein CTD PMID:24675778 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Anxa3 annexin A3 increases expression ISO Dopamine results in increased expression of ANXA3 protein CTD PMID:24675778 NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
JBrowse link
G Arg1 arginase 1 decreases expression EXP Dopamine results in decreased expression of ARG1 mRNA; Dopamine results in decreased expression of ARG1 protein CTD PMID:25818600 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB1 protein]; GRK2 protein promotes the reaction [Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB1 protein]] CTD PMID:31024316 NCBI chr 1:164,502,099...164,573,947
Ensembl chr 1:164,502,389...164,593,139
JBrowse link
G Arrb2 arrestin, beta 2 multiple interactions ISO Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB2 protein]; GRK2 protein promotes the reaction [Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB2 protein]] CTD PMID:31024316 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP Dopamine results in decreased expression of ATP2B2 mRNA CTD PMID:21983523 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d increases expression ISO Dopamine results in increased expression of ATP5PD protein CTD PMID:24675778 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression EXP Dopamine results in increased expression of B4GALT1 mRNA CTD PMID:21983523 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Dopamine results in decreased expression of BAX protein CTD PMID:19410601 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BBC3 mRNA; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BBC3 protein CTD PMID:19410601 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Dopamine results in decreased expression of BCL2 protein
polydatin inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]; Resveratrol inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]
CTD PMID:17603292 PMID:28980048 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases abundance ISO BDNF gene mutant form results in increased abundance of Dopamine CTD PMID:11421589 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression ISO [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 mRNA; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 protein CTD PMID:19410601 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G C1qbp complement C1q binding protein increases expression ISO Dopamine results in increased expression of C1QBP protein CTD PMID:24675778 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527
JBrowse link
G Calu calumenin increases expression EXP Dopamine results in increased expression of CALU mRNA CTD PMID:21983523 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Caly calcyon neuron-specific vesicular protein decreases secretion ISO CALY protein results in decreased secretion of Dopamine CTD PMID:30753204 NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP [Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]] CTD PMID:19217379 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO
EXP
[Dopamine co-treated with Zinc deficiency] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP3 protein]; Dopamine results in increased activity of and results in increased cleavage of CASP3 protein; Dopamine results in increased cleavage of and results in increased activity of CASP3 protein; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of CASP3 protein]; resveratrol inhibits the reaction [Dopamine results in increased cleavage of and results in increased activity of CASP3 protein]
Dopamine results in increased activity of CASP3 protein
SH-6 compound promotes the reaction [Dopamine results in increased activity of CASP3 protein]; SH-6 compound promotes the reaction [tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]]; tanespimycin promotes the reaction [Dopamine results in increased activity of CASP3 protein]
CTD PMID:15198987 PMID:17136323 PMID:17603292 PMID:18194434 PMID:19410601 PMID:22987761 PMID:23377617 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [Dopamine results in increased activity of and results in increased cleavage of CASP7 protein]; Dopamine results in increased activity of and results in increased cleavage of CASP7 protein
Dopamine results in increased activity of CASP7 protein
CTD PMID:17136323 PMID:19410601 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase multiple interactions
increases expression
ISO
EXP
CAT protein inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in decreased abundance of Dopamine]
Dopamine results in increased expression of CAT mRNA
[Dopamine co-treated with Dicumarol] results in increased expression of CAT mRNA
CTD PMID:11299314 PMID:11435997 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbx7 chromobox 7 decreases expression EXP Dopamine results in decreased expression of CBX7 mRNA CTD PMID:21983523 NCBI chr 7:121,136,067...121,153,503
Ensembl chr 7:121,136,058...121,153,383
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 decreases expression EXP Dopamine results in decreased expression of CCL22 mRNA CTD PMID:25818600 NCBI chr19:10,674,189...10,681,145
Ensembl chr19:10,674,189...10,681,145
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression EXP Dopamine results in increased expression of CD55 mRNA CTD PMID:21983523 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cfl1 cofilin 1 increases expression ISO Dopamine results in increased expression of CFL1 protein CTD PMID:24675778 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 decreases secretion
affects secretion
ISO CHRM5 gene mutant form results in decreased secretion of Dopamine
CHRM5 protein affects the secretion of Dopamine
CTD PMID:15213703 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit increases secretion EXP CHRNA3 protein results in increased secretion of Dopamine CTD PMID:15542623 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit multiple interactions ISO [pozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]] which results in increased secretion of Dopamine; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine] CTD PMID:17227438 PMID:19481067 NCBI chr16:68,860,018...68,866,718
Ensembl chr16:68,860,018...68,866,718
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO [pozanicline binds to and results in increased activity of [CHRNA6 protein binds to CHRNB2 protein]] which results in increased secretion of Dopamine; Nicotine inhibits the reaction [[CHRNA6 protein binds to CHRNB2 protein] which results in increased secretion of Dopamine] CTD PMID:17227438 PMID:19481067 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit increases secretion EXP CHRNB4 protein results in increased secretion of Dopamine CTD PMID:15542623 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression EXP Dopamine results in increased expression of CKAP4 mRNA CTD PMID:21983523 NCBI chr 7:24,935,243...24,947,595
Ensembl chr 7:24,939,498...24,947,595
JBrowse link
G Clic1 chloride intracellular channel 1 increases expression EXP Dopamine results in increased expression of CLIC1 mRNA CTD PMID:21983523 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression EXP Dopamine results in increased expression of COL12A1 mRNA CTD PMID:21983523 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Comt catechol-O-methyltransferase increases methylation
increases metabolic processing
multiple interactions
ISO
EXP
COMT protein results in increased methylation of Dopamine
COMT protein results in increased metabolism of Dopamine
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine]
3,4-methylenedioxyethamphetamine inhibits the reaction [COMT protein results in increased methylation of Dopamine]; [entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine inhibits the reaction [COMT protein results in increased methylation of Dopamine]
CTD PMID:7566641 PMID:11160877 PMID:11248589 PMID:12898346 PMID:14574438 PMID:15190105 PMID:19462939 PMID:20626558 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Dopamine results in increased expression of CPT1A mRNA; Dopamine results in increased expression of CPT1A protein CTD PMID:8479178 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein; Calcium promotes the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; Dopamine binds to and results in increased activity of CREB1 protein; KN 62 inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; SCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein] CTD PMID:14622123 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cs citrate synthase increases expression ISO Dopamine results in increased expression of CS protein CTD PMID:24675778 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Ctsd cathepsin D increases expression ISO Dopamine results in increased expression of CTSD protein CTD PMID:24675778 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 increases expression EXP Dopamine results in increased expression of CXCL9 mRNA CTD PMID:25818600 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
ISO Dopamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Dopamine results in decreased activity of CYP1A1 protein
CTD PMID:18420780 PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Dopamine results in decreased activity of CYP1A2 protein CTD PMID:18420780 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Dopamine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Dopamine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
increases abundance
multiple interactions
ISO Dopamine results in decreased activity of CYP2D6 protein
CYP2D6 protein results in increased abundance of Dopamine
[CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine
CTD PMID:18420780 PMID:26763401 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Dopamine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dbh dopamine beta-hydroxylase affects abundance
multiple interactions
ISO
EXP
DBH gene polymorphism affects the abundance of Dopamine
DBH protein affects the reaction [Dopamine binds to DRD2 protein]
CTD PMID:15716360 PMID:16163519 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Disc1 DISC1 scaffold protein multiple interactions ISO DISC1 protein modified form results in increased uptake of and affects the metabolism of Dopamine CTD PMID:26754951 NCBI chr19:57,818,838...58,069,992
Ensembl chr19:57,820,260...58,066,152
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
increases activity
affects localization
ISO
EXP
Dopamine binds to and results in increased activity of DRD1 protein; SCH 23390 inhibits the reaction [Dopamine affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [Dopamine results in increased activity of DRD1 protein]
[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]
[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein; [Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein; Dopamine deficiency inhibits the reaction [SCH 23390 binds to DRD1 protein]; DRD1 protein promotes the reaction [zonisamide affects the secretion of Dopamine]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]; SCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]
CTD PMID:12813475 PMID:14622123 PMID:15985612 PMID:19482038 PMID:22292096 PMID:24418703 PMID:31323226 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects response to substance
increases activity
affects binding
ISO
EXP
[Dopamine co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein; [Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]; Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB1 protein]; Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB2 protein]; GRK2 protein promotes the reaction [Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB1 protein]]; GRK2 protein promotes the reaction [Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB2 protein]]
[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]
DRD2 protein affects the susceptibility to Dopamine
Dopamine results in increased activity of DRD2 protein
[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine; [Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; DBH protein affects the reaction [Dopamine binds to DRD2 protein]; decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]; DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of IL10 protein]; DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of TGFB1 protein]; DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of VEGFA protein]; DRD2 mutant form inhibits the reaction [Dopamine results in increased expression of TNF protein]; DRD4 protein affects the reaction [Dopamine binds to DRD2 protein]; estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Ethanol affects the reaction [Dopamine binds to DRD2 protein]; GRK6 protein affects the reaction [Dopamine binds to DRD2 protein]; Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]; Olanzapine promotes the reaction [Dopamine binds to DRD2 protein]; Quetiapine Fumarate promotes the reaction [Dopamine binds to DRD2 protein]; Risperidone promotes the reaction [Dopamine binds to DRD2 protein]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]; tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]
Dopamine binds to DRD2 protein alternative form
CTD PMID:8103596 PMID:10936494 PMID:12476322 PMID:15140183 PMID:15341276 PMID:15716360 PMID:16480889 PMID:19046384 PMID:19439595 PMID:20729865 PMID:24418703 PMID:25818600 PMID:27717053 PMID:31024316 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 increases activity
multiple interactions
EXP
ISO
Dopamine results in increased activity of DRD3 protein
Butaclamol inhibits the reaction [Dopamine results in increased activity of DRD3 protein]; Dopamine binds to and results in increased activity of DRD3 protein; Endocannabinoids promotes the reaction [Dopamine binds to and results in increased activity of DRD3 protein]
[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]; [Raclopride binds to and results in decreased activity of DRD3 protein] which results in increased abundance of Dopamine; DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]; DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK3 protein]; NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]; NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK3 protein]]
CTD PMID:15341276 PMID:19046384 PMID:19217379 PMID:30102254 PMID:31323226 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions EXP
ISO
DRD4 protein affects the reaction [Dopamine binds to DRD2 protein]
Clozapine inhibits the reaction [Dopamine results in increased activity of DRD4 protein]; Dopamine binds to and results in increased activity of DRD4 protein; Endocannabinoids inhibits the reaction [Dopamine binds to and results in increased activity of DRD4 protein]
CTD PMID:15716360 PMID:30102254 PMID:31323226 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Drd5 dopamine receptor D5 increases expression EXP Dopamine results in increased expression of DRD5 mRNA CTD PMID:18522901 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Ecm2 extracellular matrix protein 2 decreases expression EXP Dopamine results in decreased expression of ECM2 mRNA CTD PMID:21983523 NCBI chr17:15,533,760...15,566,403
Ensembl chr17:15,533,972...15,566,332
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO Dopamine results in increased expression of EEF1A1 protein CTD PMID:24675778 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Efhd2 EF-hand domain family, member D2 multiple interactions
decreases secretion
ISO [EFHD2 gene mutant form affects the susceptibility to Ethanol] which results in increased secretion of Dopamine
EFHD2 gene mutant form results in decreased secretion of Dopamine
CTD PMID:28397836 NCBI chr 5:160,407,777...160,423,811
Ensembl chr 5:160,407,778...160,423,811
JBrowse link
G En1 engrailed homeobox 1 multiple interactions ISO [EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]; [EN1 protein co-treated with EN2 protein] results in increased abundance of Dopamine; NDUFS1 mutant form inhibits the reaction [[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]] CTD PMID:21892157 NCBI chr13:36,532,758...36,537,888
Ensembl chr13:36,532,758...36,537,093
JBrowse link
G En2 engrailed homeobox 2 multiple interactions ISO [EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]; [EN1 protein co-treated with EN2 protein] results in increased abundance of Dopamine; NDUFS1 mutant form inhibits the reaction [[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]] CTD PMID:21892157 NCBI chr 4:438,668...444,508
Ensembl chr 4:438,668...444,501
JBrowse link
G Eng endoglin decreases expression EXP Dopamine results in decreased expression of ENG mRNA CTD PMID:21983523 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Dopamine results in increased expression of ENPP3 mRNA CTD PMID:21983523 NCBI chr 1:21,613,148...21,684,483
Ensembl chr 1:21,613,148...21,684,480
JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression EXP Dopamine results in increased expression of ERP29 mRNA CTD PMID:21983523 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Dopamine promotes the reaction [TNF protein results in increased expression of F3 mRNA] CTD PMID:20118172 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Dopamine results in increased expression of FN1 mRNA CTD PMID:21983523 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; [Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA; [Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein; bisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Dopamine results in increased expression of FOS mRNA; Dopamine results in increased expression of FOS protein
CTD PMID:10700011 PMID:12112414 PMID:19217379 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
decreases activity
multiple interactions
EXP Dopamine results in increased activity of G6PD protein
Dopamine results in decreased activity of G6PD protein
Atenolol inhibits the reaction [Dopamine results in increased activity of G6PD protein]
CTD PMID:1978808 PMID:26820767 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO Dopamine results in increased expression of GAPDH protein CTD PMID:24675778 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gch1 GTP cyclohydrolase 1 increases abundance EXP GCH1 protein results in increased abundance of Dopamine CTD PMID:15929554 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of GCLC protein] CTD PMID:23377617 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [GCLM gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine CTD PMID:23704229 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases metabolic processing
ISO
EXP
GDNF protein inhibits the reaction [Oxidopamine results in decreased secretion of Dopamine]
GDNF protein results in increased metabolism of Dopamine
CTD PMID:12213621 PMID:15269253 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide decreases export EXP GHRL protein results in decreased export of Dopamine CTD PMID:20553917 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP Dopamine affects the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:18603625 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases localization EXP Dopamine results in increased localization of GRIA1 protein CTD PMID:19674091 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases localization EXP Dopamine results in increased localization of GRIA2 protein CTD PMID:19674091 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP [Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein] CTD PMID:14622123 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions ISO GRK2 protein promotes the reaction [Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB1 protein]]; GRK2 protein promotes the reaction [Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB2 protein]] CTD PMID:31024316 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 multiple interactions EXP GRK6 protein affects the reaction [Dopamine binds to DRD2 protein] CTD PMID:15716360 NCBI chr17:9,705,917...9,721,921
Ensembl chr17:9,703,453...9,721,574
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions EXP [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in decreased abundance of Dopamine]; [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in increased secretion of Dopamine]; [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Veratridine results in increased secretion of Dopamine]; [6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased secretion of Dopamine CTD PMID:12907309 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Dopamine results in decreased activity of GSR protein CTD PMID:26820767 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Dopamine analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Dopamine analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Dopamine analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Dopamine results in increased expression of H1-5 protein CTD PMID:24675778 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
JBrowse link
G Hcrtr1 hypocretin receptor 1 multiple interactions EXP [1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea binds to and results in decreased activity of HCRTR1 protein] inhibits the reaction [Amphetamine results in increased secretion of Dopamine] CTD PMID:19737591 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
decreases expression
ISO
EXP
[Dopamine results in increased expression of HIF1A protein] which results in increased expression of BBC3 mRNA; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BBC3 protein; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 mRNA; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of BNIP3 protein; [Dopamine results in increased expression of HIF1A protein] which results in increased expression of TP53 protein; Dopamine results in increased expression of HIF1A protein
Clodronic Acid inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]; eticlopride inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]; zoledronic acid inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]
[Dopamine results in increased expression of HIF1A protein] which results in increased expression of and results in increased phosphorylation of TP53 protein; Acetylcysteine inhibits the reaction [Dopamine results in increased expression of HIF1A protein]
CTD PMID:19410601 PMID:25818600 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Dopamine results in decreased expression of HMGCS2 mRNA CTD PMID:21983523 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
[Dopamine results in increased expression of HMOX1 mRNA] which results in increased expression of SOD2 mRNA; Dopamine results in increased expression of HMOX1 mRNA
[SNCA protein co-treated with Dopamine] results in increased expression of HMOX1 protein; [SNCA protein co-treated with Paraquat co-treated with Dopamine] results in increased expression of HMOX1 protein; HMOX1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased abundance of Dopamine]
CTD PMID:10942521 PMID:18799798 PMID:21735318 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine] CTD PMID:10661506 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Dopamine results in increased expression of HSP90AB1 protein CTD PMID:24675778 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 increases expression ISO Dopamine results in increased expression of HSP90B1 protein CTD PMID:24675778 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Dopamine results in increased expression of HSPA5 protein CTD PMID:24675778 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO Dopamine results in increased expression of HSPA9 protein CTD PMID:24675778 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP [4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine; Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]] CTD PMID:10773215 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions ISO HTR2C protein affects the reaction [Cocaine results in increased abundance of Dopamine] CTD PMID:12427861 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions ISO Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]; Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] CTD PMID:17360702 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Htr3b 5-hydroxytryptamine receptor 3B multiple interactions ISO Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3B protein] CTD PMID:17360702 NCBI chr 8:53,247,881...53,278,170
Ensembl chr 8:53,248,705...53,277,859
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
EXP Dopamine results in decreased expression of IL10 mRNA; Dopamine results in decreased expression of IL10 protein
DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of IL10 protein]; eticlopride inhibits the reaction [Dopamine results in decreased expression of IL10 protein]
CTD PMID:25818600 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Ins2 insulin 2 multiple interactions
increases secretion
increases expression
ISO Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein]
Dopamine results in increased secretion of INS protein
Dopamine results in increased expression of INS protein
CTD PMID:18645345 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation
multiple interactions
ISO Dopamine results in increased phosphorylation of JUN protein
PRKN protein inhibits the reaction [Dopamine results in increased phosphorylation of JUN protein]
CTD PMID:15198987 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 multiple interactions EXP KCNA1 protein affects the reaction [Amphetamine results in increased secretion of Dopamine] CTD PMID:12700677 NCBI chr 4:159,190,781...159,192,526
Ensembl chr 4:159,190,804...159,192,526
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 decreases abundance ISO KCNJ6 gene mutant form results in decreased abundance of Dopamine CTD PMID:15256069 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP Dopamine results in increased expression of KDELR3 mRNA CTD PMID:21983523 NCBI chr 7:120,749,680...120,760,163
Ensembl chr 7:120,749,752...120,760,160
JBrowse link
G Kpna2 karyopherin subunit alpha 2 increases expression EXP Dopamine results in increased expression of KPNA2 mRNA CTD PMID:21983523 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Lgmn legumain increases expression EXP Dopamine results in increased expression of LGMN mRNA CTD PMID:21983523 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Dopamine results in increased expression of LITAF mRNA CTD PMID:21983523 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
JBrowse link
G Lmna lamin A/C increases expression ISO Dopamine results in increased expression of LMNA protein CTD PMID:24675778 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO Dopamine results in increased expression of HSPA6 protein CTD PMID:24675778 NCBI chr13:89,408,703...89,411,500 JBrowse link
G Loxl2 lysyl oxidase-like 2 increases expression EXP Dopamine results in increased expression of LOXL2 mRNA CTD PMID:21983523 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Dopamine results in increased expression of LRAT mRNA CTD PMID:21983523 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 multiple interactions ISO LRRK2 mutant form results in increased susceptibility to [Dopamine co-treated with SLC6A3 protein] CTD PMID:23628791 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Maoa monoamine oxidase A increases abundance
decreases amination
multiple interactions
ISO MAOA mutant form results in increased abundance of Dopamine
MAOA protein results in decreased amination of Dopamine
3,4-Methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOA protein results in decreased amination of Dopamine]
CTD PMID:11834493 PMID:26721607 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B multiple interactions
increases degradation
decreases amination
EXP
ISO
[Ro 16-6491 results in decreased activity of MAOB protein] which results in decreased susceptibility to Dopamine; [Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopamine
MAOB protein results in increased degradation of Dopamine
1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane inhibits the reaction [MAOB protein results in increased degradation of Dopamine]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [MAOB protein results in decreased amination of Dopamine]; Selegiline inhibits the reaction [MAOB protein results in decreased amination of Dopamine]; Selegiline inhibits the reaction [MAOB protein results in increased degradation of Dopamine]
CTD PMID:16012872 PMID:20875051 PMID:26721607 PMID:30036687 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Dopamine results in increased phosphorylation of and results in increased activity of MAPK1 protein; RGS3 protein affects the reaction [Dopamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]; DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]; NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]
CTD PMID:16760913 PMID:18977218 PMID:19217379 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
Dopamine results in increased phosphorylation of and results in increased activity of MAPK3 protein; RGS3 protein affects the reaction [Dopamine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK3 protein]; NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK3 protein]]
CTD PMID:16760913 PMID:18977218 PMID:19217379 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein] CTD PMID:17481858 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Dopamine metabolite promotes the reaction [MAPT protein binds to MAPT protein]; Dopamine promotes the reaction [MAPT protein binds to MAPT protein] CTD PMID:16180106 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate increases expression ISO Dopamine results in increased expression of MARCKS protein CTD PMID:24675778 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression EXP Dopamine results in decreased expression of MRC1 mRNA; Dopamine results in decreased expression of MRC1 protein CTD PMID:25818600 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [MT1 co-treated with Dopamine] results in decreased abundance of semiquinone radicals; [MT1 gene mutant form co-treated with MT2 gene mutant form co-treated with Mercuric Chloride] results in decreased abundance of Dopamine CTD PMID:17910954 PMID:18226494 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [MT1 gene mutant form co-treated with MT2 gene mutant form co-treated with Mercuric Chloride] results in decreased abundance of Dopamine CTD PMID:18226494 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Dopamine results in decreased phosphorylation of MTOR protein CTD PMID:19410601 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions
increases activity
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]; Ethanol promotes the reaction [Dopamine results in increased activity of MTR protein]; wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Myct1 myc target 1 decreases expression EXP Dopamine results in decreased expression of MYCT1 mRNA CTD PMID:21983523 NCBI chr 1:42,121,572...42,132,131
Ensembl chr 1:42,121,636...42,131,547
JBrowse link
G Ncl nucleolin increases expression ISO Dopamine results in increased expression of NCL protein CTD PMID:24675778 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions ISO NDUFS1 mutant form inhibits the reaction [[EN1 protein co-treated with EN2 protein] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]] CTD PMID:21892157 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO NDUFS4 protein affects the reaction [Rotenone results in increased abundance of Dopamine]; Paclitaxel inhibits the reaction [NDUFS4 protein affects the reaction [Rotenone results in increased abundance of Dopamine]] CTD PMID:21383081 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Dopamine results in increased expression of NFKBIZ mRNA CTD PMID:21983523 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Dopamine] CTD PMID:11085313 PMID:20575850 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
Atenolol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; carvedilol inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Dopamine results in increased expression of NOS2 mRNA; Dopamine results in increased expression of NOS2 protein
CTD PMID:19439816 PMID:25818600 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppc natriuretic peptide C multiple interactions EXP NPPC protein inhibits the reaction [Cocaine results in increased abundance of Dopamine] CTD PMID:11860464 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases abundance
multiple interactions
ISO NR3C1 protein results in increased abundance of Dopamine
[RU 43044 binds to and results in decreased activity of NR3C1 protein] inhibits the reaction [Methamphetamine results in increased secretion of Dopamine]
CTD PMID:11226678 PMID:18925659 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression EXP Dopamine results in increased expression of NRIP3 mRNA CTD PMID:21983523 NCBI chr 1:174,385,424...174,411,141
Ensembl chr 1:174,385,424...174,411,141
JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Dopamine results in increased expression of NTF3 mRNA; Dopamine results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Omd osteomodulin decreases expression EXP Dopamine results in decreased expression of OMD mRNA CTD PMID:21983523 NCBI chr17:15,476,100...15,484,324
Ensembl chr17:15,475,710...15,484,269
Ensembl chr17:15,475,710...15,484,269
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions EXP [U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine] CTD PMID:11113311 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of PARP1 protein]; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of PARP1 protein]; resveratrol inhibits the reaction [Dopamine results in increased cleavage of PARP1 protein]; Zinc deficiency promotes the reaction [Dopamine results in increased cleavage of PARP1 protein]
[PARP1 protein results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] which results in increased abundance of Dopamine
CTD PMID:10318960 PMID:15198987 PMID:17603292 PMID:19410601 PMID:22987761 PMID:23377617 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 multiple interactions
decreases expression
ISO 1,3-dimethylthiourea inhibits the reaction [Dopamine results in decreased expression of PCMT1 mRNA]; Acetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 mRNA]; Acetylcysteine inhibits the reaction [Dopamine results in decreased expression of PCMT1 protein]
Dopamine results in decreased expression of PCMT1 mRNA; Dopamine results in decreased expression of PCMT1 protein
CTD PMID:24631677 NCBI chr 1:1,734,863...1,767,759
Ensembl chr 1:1,736,276...1,767,618
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression ISO Dopamine results in decreased expression of PDIA3 protein CTD PMID:24675778 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression EXP Dopamine results in increased expression of PDIA6 mRNA CTD PMID:21983523 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Dopamine results in decreased activity of PGD protein CTD PMID:26820767 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Pgk1 phosphoglycerate kinase 1 decreases expression EXP Dopamine results in decreased expression of PGK1 mRNA CTD PMID:21983523 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Phb prohibitin increases expression ISO Dopamine results in increased expression of PHB protein CTD PMID:24675778 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions
affects abundance
ISO [PINK1 mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine; Paraquat affects the reaction [PINK1 protein affects the abundance of Dopamine] CTD PMID:22043175 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression ISO Dopamine results in increased expression of PKM protein CTD PMID:24675778 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pld3 phospholipase D family, member 3 affects expression ISO Dopamine affects the expression of PLD3 protein CTD PMID:24675778 NCBI chr 1:84,339,269...84,361,686
Ensembl chr 1:84,339,261...84,353,725
JBrowse link
G Plp2 proteolipid protein 2 increases expression EXP Dopamine results in increased expression of PLP2 mRNA CTD PMID:21983523 NCBI chr  X:15,679,254...15,682,653
Ensembl chr  X:15,679,254...15,682,652
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine] CTD PMID:15689546 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Potef POTE ankyrin domain family, member F increases expression ISO Dopamine results in increased expression of POTEF protein CTD PMID:24675778 NCBI chr18:24,780,521...24,783,147
Ensembl chr 3:75,643,054...75,644,954
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Dopamine results in increased expression of PRDX3 protein CTD PMID:24675778 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO [rottlerin results in decreased activity of PRKCD protein] inhibits the reaction [Methamphetamine results in increased metabolism of Dopamine]; PRKCD protein affects the reaction [Methamphetamine results in increased metabolism of Dopamine] CTD PMID:22512859 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions
increases expression
ISO PRKN protein inhibits the reaction [Dopamine results in increased abundance of Reactive Oxygen Species]; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of CASP3 protein]; PRKN protein inhibits the reaction [Dopamine results in increased cleavage of PARP1 protein]; PRKN protein inhibits the reaction [Dopamine results in increased phosphorylation of JUN protein]
PRKN mutant form results in increased abundance of and results in increased metabolism of Dopamine; PRKN protein affects the abundance of and affects the metabolism of Dopamine; PRKN protein promotes the reaction [Amphetamine results in increased abundance of Dopamine]
Dopamine results in increased expression of PRKN mRNA
CTD PMID:12915482 PMID:15198987 PMID:15993444 PMID:16987221 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Prl prolactin multiple interactions
decreases secretion
decreases expression
ISO
EXP
Domperidone inhibits the reaction [Dopamine results in decreased expression of PRL protein]
Haloperidol inhibits the reaction [Dopamine results in decreased secretion of PRL protein]; Risperidone inhibits the reaction [Dopamine results in decreased secretion of PRL protein]
CTD PMID:1380082 PMID:8532072 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Pros1 protein S increases expression EXP Dopamine results in increased expression of PROS1 mRNA CTD PMID:21983523 NCBI chr 7:1,206,648...1,288,140
Ensembl chr 7:1,206,648...1,288,134
JBrowse link
G Ptrh1 peptidyl-tRNA hydrolase 1 homolog increases expression EXP Dopamine results in increased expression of PTRH1 mRNA CTD PMID:21983523 NCBI chr 3:11,811,303...11,817,007
Ensembl chr 3:11,811,962...11,825,640
JBrowse link
G Rack1 receptor for activated C kinase 1 increases expression ISO Dopamine results in increased expression of RACK1 protein CTD PMID:24675778 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP Dopamine results in increased expression of RAN mRNA CTD PMID:21983523 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases expression EXP Dopamine results in increased expression of RANGAP1 mRNA CTD PMID:21983523 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO RGS3 protein affects the reaction [Dopamine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; RGS3 protein affects the reaction [Dopamine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18977218 NCBI chr 5:78,429,017...78,567,281
Ensembl chr 5:78,428,669...78,567,288
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [Dopamine co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein CTD PMID:27717053 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Dopamine results in decreased phosphorylation of RPS6KB1 protein CTD PMID:19410601 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rpsa ribosomal protein SA increases expression ISO Dopamine results in increased expression of RPSA protein CTD PMID:24675778 NCBI chr 8:128,806,053...128,809,987
Ensembl chr 8:128,806,129...128,809,986
JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 increases expression ISO Dopamine results in increased expression of RUVBL1 protein CTD PMID:24675778 NCBI chr 4:120,411,917...120,447,458
Ensembl chr 4:120,411,991...120,447,455
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression EXP Dopamine results in increased expression of S100A11 mRNA CTD PMID:21983523 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Dopamine results in increased expression of S100A4 mRNA CTD PMID:21983523 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Sct secretin increases metabolic processing ISO SCT protein results in increased metabolism of Dopamine CTD PMID:16168596 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Septin9 septin 9 decreases expression ISO Dopamine results in decreased expression of SEPTIN9 protein CTD PMID:24675778 NCBI chr10:106,208,308...106,340,747
Ensembl chr10:106,264,434...106,348,490
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 increases expression ISO Dopamine results in increased expression of SHMT2 protein CTD PMID:24675778 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions ISO Dopamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions
increases uptake
decreases activity
affects binding
decreases abundance
ISO
EXP
Heptachlor Epoxide inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; para-methyl-4-methylaminorex inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]
DDT inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; Dichlorodiphenyldichloroethane inhibits the reaction [SLC18A2 protein results in increased uptake of Dopamine]; SLC18A2 protein affects the transport of and affects the abundance of Dopamine
Dopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]
Dopamine results in decreased activity of SLC18A2 protein
Dopamine binds to SLC18A2 protein
SLC18A2 results in decreased abundance of Dopamine
CTD PMID:1438304 PMID:7912402 PMID:10499361 PMID:15475732 PMID:18533268 PMID:19409267 PMID:27287315 PMID:29908239 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions EXP Dopamine affects the reaction [SLC22A1 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Dopamine inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:45,658,398...45,669,192 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions EXP Dopamine affects the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:12440152 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions
ISO
EXP
SLC22A3 protein results in increased uptake of Dopamine
Dopamine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]; Dopamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Dopamine inhibits the reaction [SLC22A3 protein results in increased uptake of Dopamine]
CTD PMID:9830022 PMID:20858707 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc25a14 solute carrier family 25 member 14 multiple interactions
decreases response to substance
increases expression
ISO Dactinomycin inhibits the reaction [Dopamine results in increased expression of SLC25A14 mRNA]; SLC25A14 protein inhibits the reaction [Dopamine results in increased abundance of Superoxides]
SLC25A14 protein results in decreased susceptibility to Dopamine
CTD PMID:20600837 NCBI chr  X:135,470,855...135,509,223
Ensembl chr  X:135,470,915...135,509,221
JBrowse link
G Slc25a5 solute carrier family 25 member 5 increases expression ISO Dopamine results in increased expression of SLC25A5 protein CTD PMID:24675778 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc25a6 solute carrier family 25 member 6 increases expression ISO Dopamine results in increased expression of SLC25A6 protein CTD PMID:24675778 NCBI chr18:70,959,872...70,961,040
Ensembl chr18:70,959,887...70,960,786
JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Dopamine CTD PMID:20858707 NCBI chr12:13,914,114...13,924,511
Ensembl chr12:13,914,114...13,924,531
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Dopamine results in decreased expression of SLC2A4 mRNA CTD PMID:21983523 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression EXP Dopamine results in increased expression of SLC39A11 mRNA CTD PMID:21983523 NCBI chr10:101,754,842...102,169,100
Ensembl chr10:101,754,830...102,084,035
JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression EXP Dopamine results in increased expression of SLC41A2 mRNA CTD PMID:21983523 NCBI chr 7:26,522,314...26,607,861
Ensembl chr 7:26,522,314...26,607,861
JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions
increases uptake
ISO Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]
SLC6A2 protein results in increased uptake of Dopamine
CTD PMID:17234900 PMID:20626558 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects uptake
increases import
decreases import
increases response to substance
increases uptake
affects localization
affects export
affects abundance
increases transport
increases export
ISO
EXP
2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; 4-fluoroamphetamine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; 4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; [Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA; [Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone] which affects the uptake of Dopamine; [SLC6A3 protein polymorphism affects the susceptibility to Bupropion] which affects the uptake of Dopamine; [SLC6A3 protein polymorphism affects the susceptibility to Citalopram] which affects the uptake of Dopamine; [SLC6A3 protein polymorphism affects the susceptibility to Cocaine] which affects the uptake of Dopamine; [SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate] which affects the uptake of Dopamine; [SNCA protein affects the localization of SLC6A3 protein] which affects the uptake of Dopamine; Amphetamine inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Amphetamine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; bisindolylmaleimide I inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Bupropion inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Bupropion inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Bupropion inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Bupropion promotes the reaction [SLC6A3 protein results in increased import of Dopamine]; Butyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]; Butyrates inhibits the reaction [Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]]; Citalopram inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; decamethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Dextroamphetamine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Fluoxetine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Ketamine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; LRRK2 mutant form results in increased susceptibility to [Dopamine co-treated with SLC6A3 protein]; Mazindol inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Melitten inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Nomifensine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; para-methyl-4-methylaminorex inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Permethrin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]; Sulpiride inhibits the reaction [Dopamine affects the localization of SLC6A3 protein]; Sulpiride inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; vanoxerine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; Wortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
SLC6A3 protein polymorphism affects the uptake of Dopamine
SLC6A3 protein results in increased susceptibility to Dopamine
DAT protein results in increased uptake of Dopamine
SLC6A3 protein affects the export of Dopamine
[bisphenol A co-treated with Estradiol] inhibits the reaction [SLC6A3 protein affects the export of Dopamine]; [Dichlorodiphenyl Dichloroethylene co-treated with Estradiol] promotes the reaction [SLC6A3 protein affects the export of Dopamine]; bisphenol A affects the reaction [SLC6A3 protein affects the export of Dopamine]; Cocaine promotes the reaction [SLC6A3 protein affects the uptake of Dopamine]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [SLC6A3 protein affects the export of Dopamine]; Dieldrin inhibits the reaction [SLC6A3 protein affects the export of Dopamine]; Diethylstilbestrol affects the reaction [SLC6A3 protein affects the export of Dopamine]; Endosulfan inhibits the reaction [SLC6A3 protein affects the export of Dopamine]; Estradiol affects the reaction [SLC6A3 protein affects the export of Dopamine]; modafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]; nonylphenol affects the reaction [SLC6A3 protein affects the export of Dopamine]
SLC6A3 protein affects the abundance of Dopamine
[Chlorodiphenyl (54% Chlorine) co-treated with aroclor 1260] inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]; [decamethrin results in increased expression of SLC6A3 protein] which results in increased uptake of Dopamine; DDT inhibits the reaction [DAT protein results in increased uptake of Dopamine]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [DAT protein results in increased uptake of Dopamine]; Dichlorodiphenyldichloroethane inhibits the reaction [DAT protein results in increased uptake of Dopamine]; Heptachlor promotes the reaction [SLC6A3 protein results in increased uptake of Dopamine]; SLC6A3 mutant form affects the reaction [Cocaine affects the abundance of and affects the uptake of Dopamine]; SLC6A3 mutant form affects the reaction [Fluoxetine affects the abundance of Dopamine]; SLC6A3 mutant form promotes the reaction [Citalopram results in increased abundance of Dopamine]; SLC6A3 protein affects the reaction [[Cocaine co-treated with Alcohols] results in increased uptake of Dopamine]; SLC6A3 protein affects the reaction [Alcohols results in increased uptake of Dopamine]; SLC6A3 protein affects the reaction [Cocaine results in increased uptake of Dopamine]; SLC6A3 protein affects the reaction [Methamphetamine affects the abundance of Dopamine]; SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]; vanoxerine inhibits the reaction [SLC6A3 protein promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of Dopamine]]
SLC6A3 protein results in increased transport of Dopamine
CTD PMID:9634552 PMID:11165777 PMID:11294980 PMID:11707631 PMID:12112414 PMID:14691264 PMID:16005927 PMID:16702228 PMID:17234900 PMID:17250655 PMID:18533268 PMID:18614672 PMID:18690110 PMID:19032594 PMID:19197004 PMID:19479021 PMID:20035724 PMID:20875051 PMID:20969853 PMID:22342763 PMID:23313730 PMID:23628791 PMID:25630971 PMID:27555326 PMID:29908239 PMID:30776375 PMID:31009648 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Snca synuclein alpha increases response to substance
decreases abundance
affects uptake
multiple interactions
increases abundance
affects response to substance
affects abundance
ISO
EXP
SNCA gene mutant form results in increased susceptibility to Dopamine
SNCA protein results in decreased abundance of Dopamine
SNCA protein affects the uptake of Dopamine
[SNCA protein affects the localization of SLC6A3 protein] which affects the uptake of Dopamine; [SNCA protein co-treated with Dopamine] results in increased expression of HMOX1 protein; [SNCA protein co-treated with Paraquat co-treated with Dopamine] results in increased expression of HMOX1 protein; Dopamine inhibits the reaction [SNCA protein results in decreased abundance of Dopamine]; Dopamine inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; Dopamine inhibits the reaction [SNCA protein results in increased abundance of Thiobarbituric Acid Reactive Substances]; geraniol inhibits the reaction [SNCA protein results in decreased abundance of Dopamine]; TRAP1 protein inhibits the reaction [SNCA protein affects the abundance of Dopamine]
SNCA protein results in increased abundance of Dopamine
SNCA protein promotes the reaction [Rotenone results in decreased abundance of Dopamine]
SNCA protein mutant form results in decreased abundance of Dopamine
SNCA affects the susceptibility to Dopamine
CTD PMID:15234109 PMID:17131421 PMID:18622040 PMID:19032594 PMID:19409267 PMID:21735318 PMID:22319455 PMID:26075822 PMID:27026137 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects binding
decreases expression
EXP
ISO
[Copper Sulfate co-treated with Dopamine] results in decreased expression of SOD1 mRNA; [Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD1 mRNA
Dopamine binds to SOD1 protein mutant form
Dopamine results in decreased expression of SOD1 mRNA
CTD PMID:11299314 PMID:23612299 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
decreases expression
multiple interactions
EXP [Dopamine results in increased expression of HMOX1 mRNA] which results in increased expression of SOD2 mRNA; Dopamine results in increased expression of SOD2 mRNA
Dopamine results in decreased expression of SOD2 mRNA
[Dopamine co-treated with Dicumarol co-treated with Copper Sulfate] results in decreased expression of SOD2 mRNA
CTD PMID:10942521 PMID:11299314 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression ISO Dopamine results in increased expression of SSBP1 protein CTD PMID:24675778 NCBI chr 4:68,634,844...68,645,112
Ensembl chr 4:68,634,929...68,645,172
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases metabolic processing
ISO
EXP
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of Dopamine]
SULT1A1 protein results in increased metabolism of Dopamine
CTD PMID:10623578 PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Syn1 synapsin I multiple interactions ISO SYN1 protein affects the reaction [Cocaine results in increased secretion of Dopamine] CTD PMID:16554471 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198
JBrowse link
G Syn2 synapsin II multiple interactions ISO SYN2 protein affects the reaction [Cocaine results in increased secretion of Dopamine] CTD PMID:16554471 NCBI chr 4:147,037,179...147,195,096
Ensembl chr 4:147,037,179...147,195,096
JBrowse link
G Syn3 synapsin III multiple interactions ISO SYN3 protein affects the reaction [Cocaine results in increased secretion of Dopamine] CTD PMID:16554471 NCBI chr 7:23,403,896...23,808,602
Ensembl chr 7:23,403,891...23,808,602
JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO Citalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Desipramine inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; SLC6A2 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP [Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine; [Tolmetin results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine CTD PMID:16952380 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tfam transcription factor A, mitochondrial decreases abundance ISO TFAM gene mutant form results in decreased abundance of Dopamine CTD PMID:28595911 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
decreases expression
EXP Dopamine results in increased expression of TGFB1 mRNA
DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of TGFB1 protein]; eticlopride inhibits the reaction [Dopamine results in decreased expression of TGFB1 protein]
CTD PMID:16760913 PMID:25818600 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Dopamine results in increased expression of TGFB2 mRNA CTD PMID:16760913 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Th tyrosine hydroxylase increases chemical synthesis
affects abundance
decreases activity
multiple interactions
affects chemical synthesis
ISO
EXP
TH protein results in increased chemical synthesis of Dopamine
TH protein affects the abundance of Dopamine
TH affects the abundance of Dopamine
Dopamine results in decreased activity of TH protein
1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]; [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]; [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Dopamine; [Selenium deficiency results in increased activity of TH protein] which results in increased chemical synthesis of Dopamine; Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; dicarbine inhibits the reaction [Dopamine results in decreased activity of TH protein]; Paraquat promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]; Sulpiride inhibits the reaction [Dopamine results in decreased activity of TH protein]; Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]]
TH protein affects the chemical synthesis of Dopamine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine promotes the reaction [[Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine]; [Clozapine results in increased activity of TH protein] which results in increased metabolism of Dopamine; [TH protein affects the abundance of Dopamine] which affects the susceptibility to Methamphetamine; [TH protein affects the chemical synthesis of Dopamine] which affects the susceptibility to Methamphetamine
CTD PMID:2884129 PMID:8707341 PMID:9822156 PMID:10661506 PMID:10984662 PMID:11113527 PMID:16402076 PMID:16415089 PMID:19067675 PMID:19815691 PMID:20615977 PMID:20729865 PMID:24743698 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP Dopamine results in increased expression of THBS1 mRNA CTD PMID:21983523 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Dopamine results in increased expression of TIMP1 mRNA CTD PMID:21983523 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Dopamine results in increased expression of TLR2 mRNA CTD PMID:21983523 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem97 transmembrane protein 97 increases expression EXP Dopamine results in increased expression of TMEM97 mRNA CTD PMID:21983523 NCBI chr10:65,811,455...65,820,538
Ensembl chr10:65,811,456...65,820,538
JBrowse link
G Tnc tenascin C increases expression EXP Dopamine results in increased expression of TNC mRNA CTD PMID:21983523 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases uptake
ISO
EXP
Dopamine promotes the reaction [TNF protein results in increased expression of F3 mRNA]; TNF protein inhibits the reaction [Methamphetamine results in decreased uptake of Dopamine]; TNF protein inhibits the reaction [Methamphetamine results in increased secretion of Dopamine]
vanoxerine inhibits the reaction [Dopamine analog results in increased expression of TNF protein]
Dopamine results in increased expression of TNF protein
Bucladesine inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Colforsin inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; DRD2 mutant form inhibits the reaction [Dopamine results in increased expression of TNF protein]; eticlopride inhibits the reaction [Dopamine results in increased expression of TNF protein]; ICI 118551 inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Metoprolol inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]; Propranolol inhibits the reaction [Dopamine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]]
TNF protein results in increased uptake of Dopamine
CTD PMID:14999072 PMID:15081246 PMID:20118172 PMID:25818600 PMID:27026709 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Dopamine results in decreased expression of TNFSF10 mRNA CTD PMID:21983523 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [Dopamine results in increased expression of HIF1A protein] which results in increased expression of and results in increased phosphorylation of TP53 protein
[Dopamine results in increased expression of HIF1A protein] which results in increased expression of TP53 protein
CTD PMID:19410601 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpm4 tropomyosin 4 increases expression EXP Dopamine results in increased expression of TPM4 mRNA CTD PMID:21983523 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Trap1 TNF receptor-associated protein 1 multiple interactions ISO TRAP1 protein inhibits the reaction [SNCA protein affects the abundance of Dopamine] CTD PMID:22319455 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression EXP Dopamine results in increased expression of TUBB4B mRNA CTD PMID:21983523 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression
decreases expression
EXP
ISO
Dopamine results in increased expression of TUBB5 mRNA
Dopamine results in decreased expression of TUBB protein
CTD PMID:21983523 PMID:24675778 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Dopamine results in increased expression of TUBB6 mRNA CTD PMID:21983523 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial increases expression ISO Dopamine results in increased expression of TUFM protein CTD PMID:24675778 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression EXP Dopamine results in increased expression of UBE2L3 mRNA CTD PMID:21983523 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476
JBrowse link
G Vcan versican increases expression EXP Dopamine results in increased expression of VCAN mRNA CTD PMID:21983523 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression ISO Dopamine results in increased expression of VDAC1 protein CTD PMID:24675778 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vdac2 voltage-dependent anion channel 2 affects expression ISO Dopamine affects the expression of VDAC2 protein CTD PMID:24675778 NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551
JBrowse link
G Vdr vitamin D receptor increases abundance ISO VDR protein results in increased abundance of Dopamine CTD PMID:27450565 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
EXP Dopamine results in decreased expression of VEGFA mRNA; Dopamine results in decreased expression of VEGFA protein
DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of VEGFA protein]; eticlopride inhibits the reaction [Dopamine results in decreased expression of VEGFA mRNA]; eticlopride inhibits the reaction [Dopamine results in decreased expression of VEGFA protein]
CTD PMID:25818600 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
fenoterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO [Fenoterol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Fenoterol binds to and results in increased activity of ADRB1 protein; Fenoterol inhibits the reaction [cyanopindolol binds to ADRB1 protein] CTD PMID:14730417 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases phosphorylation
ISO
EXP
[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium; [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Fenoterol binds to and results in increased activity of ADRB2 protein; Fenoterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]
Fenoterol results in increased phosphorylation of ADRB2 protein
[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine; [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]; CGP 20712A inhibits the reaction [[Fenoterol binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Phenylephrine]; Fenoterol binds to and results in increased activity of ADRB2 protein
CTD PMID:7969507 PMID:8102213 PMID:14722251 PMID:14730417 PMID:16474418 PMID:16980553 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [Fenoterol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Fenoterol binds to and results in increased activity of ADRB3 protein; Fenoterol inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol] CTD PMID:19462961 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Fenoterol results in increased expression of EDNRB mRNA CTD PMID:16340002 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Epo erythropoietin increases expression ISO Fenoterol results in increased expression of EPO protein CTD PMID:9209250 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Fenoterol results in increased activity of G6PD protein CTD PMID:1978808 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Lep leptin decreases secretion ISO Fenoterol results in decreased secretion of LEP protein CTD PMID:11022189 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:16980553 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Fenoterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:16980553 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol; Ascorbic Acid inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; CAT protein inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Sodium Azide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Sodium Cyanide inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol] CTD PMID:19462961 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Ren renin increases activity
increases expression
ISO Fenoterol results in increased activity of REN protein
Fenoterol results in increased expression of REN protein
CTD PMID:2829953 PMID:9209250 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
formoterol fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO ICI 118551 inhibits the reaction [Formoterol Fumarate results in decreased expression of ACTA2 protein]
Formoterol Fumarate results in decreased expression of ACTA2 mRNA; Formoterol Fumarate results in decreased expression of ACTA2 protein
CTD PMID:21603974 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO [Formoterol Fumarate binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Formoterol Fumarate binds to and results in increased activity of ADRB1 protein; Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB1 protein] CTD PMID:14730417 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases phosphorylation
affects expression
ISO [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]; Formoterol Fumarate binds to and results in increased activity of ADRB2 protein; Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Formoterol Fumarate promotes the reaction [Cycloheximide results in increased expression of ADRB2 mRNA]; ICI 118551 inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA]
Formoterol Fumarate results in increased phosphorylation of ADRB2 protein
CTD PMID:14722251 PMID:14730417 PMID:16980553 PMID:20061444 PMID:24705868 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO [Formoterol Fumarate binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Formoterol Fumarate binds to and results in increased activity of ADRB3 protein; Formoterol Fumarate inhibits the reaction [cyanopindolol binds to ADRB3 protein] CTD PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Formoterol Fumarate results in decreased expression of BCL2 mRNA; Formoterol Fumarate results in decreased expression of BCL2 protein CTD PMID:14687023 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CCL5 protein CTD PMID:15679717 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CSF2 protein CTD PMID:15679717 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Il10 interleukin 10 decreases expression EXP Formoterol Fumarate results in decreased expression of IL10 mRNA CTD PMID:16908771 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions EXP desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 mRNA]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL13 protein] CTD PMID:26003274 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate] CTD PMID:20061444 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions EXP
ISO
desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]]; desisobutyrylciclesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 protein]]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 protein]; Formoterol Fumarate promotes the reaction [desisobutyrylciclesonide inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased expression of IL4 mRNA]]
Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]
CTD PMID:18076728 PMID:26003274 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 affects expression
increases expression
multiple interactions
EXP Formoterol Fumarate affects the expression of IL6 mRNA; Formoterol Fumarate affects the expression of IL6 protein
Formoterol Fumarate results in increased expression of IL6 mRNA
Formoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:10525314 PMID:11096136 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Formoterol Fumarate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Formoterol Fumarate results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15603589 PMID:16980553 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Formoterol Fumarate binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Formoterol Fumarate results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15603589 PMID:16980553 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP [Formoterol Fumarate co-treated with desisobutyrylciclesonide] inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of MAPK8 protein]; Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of MAPK8 protein] CTD PMID:26003274 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Formoterol Fumarate inhibits the reaction [dinitrophenyl-bovine serum albumin results in increased phosphorylation of MAPK9 protein] CTD PMID:26003274 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Budesonide promotes the reaction [Formoterol Fumarate inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]]; Formoterol Fumarate inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]; Formoterol Fumarate promotes the reaction [Budesonide inhibits the reaction [Cadmium Chloride results in increased activity of MMP9 protein]]; Ipratropium promotes the reaction [Formoterol Fumarate inhibits the reaction [Cadmium results in increased activity of MMP9 protein]] CTD PMID:20826145 PMID:25313925 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO [Beclomethasone co-treated with Formoterol Fumarate] affects the localization of NR3C1 protein CTD PMID:15679717 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Rnase3 ribonuclease A family member 3 decreases expression ISO Formoterol Fumarate results in decreased expression of RNASE3 protein CTD PMID:1443864 NCBI chr15:28,216,744...28,217,614
Ensembl chr15:28,216,744...28,217,614
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake
ISO Budesonide inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; Fluticasone inhibits the reaction [SLC22A3 protein results in increased uptake of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [beclomethasone 17-monopropionate results in decreased transport of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Budesonide results in decreased transport of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [desisobutyrylciclesonide results in decreased transport of Formoterol Fumarate]; SLC22A3 protein results in increased susceptibility to [Fluticasone results in decreased transport of Formoterol Fumarate] CTD PMID:17920670 PMID:21914487 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tnf tumor necrosis factor affects expression
multiple interactions
EXP
ISO
Formoterol Fumarate affects the expression of TNF mRNA; Formoterol Fumarate affects the expression of TNF protein
Formoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Formoterol Fumarate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate; Budesonide inhibits the reaction [[TNF protein co-treated with IL1B protein] results in decreased susceptibility to Formoterol Fumarate]
CTD PMID:10525314 PMID:11096136 PMID:20061444 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
isoprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression ISO Isoproterenol results in increased expression of A2M mRNA CTD PMID:21335049 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Isoproterenol results in increased expression of ABCA1 mRNA CTD PMID:20003209 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Isoproterenol results in increased expression of ABCB1A mRNA CTD PMID:20003209 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP
ISO
Isoproterenol results in decreased expression of ABCB4 mRNA CTD PMID:24286936 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression
increases expression
ISO
EXP
Isoproterenol results in decreased expression of ABCC3 mRNA
Isoproterenol results in increased expression of ABCC3 mRNA
CTD PMID:21335049 PMID:24286936 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Isoproterenol results in increased expression of ABCC4 mRNA CTD PMID:20003209 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Isoproterenol results in increased expression of ABCG2 mRNA CTD PMID:20003209 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Isoproterenol results in increased expression of ABHD2 mRNA CTD PMID:20211217 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Isoproterenol results in increased expression of ABHD4 mRNA CTD PMID:20003209 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
JBrowse link
G Abi3 ABI family, member 3 increases expression ISO Isoproterenol results in increased expression of ABI3 mRNA CTD PMID:20003209 NCBI chr10:83,644,086...83,655,182
Ensembl chr10:83,644,086...83,655,182
JBrowse link
G Ablim3 actin binding LIM protein family, member 3 increases expression ISO Isoproterenol results in increased expression of ABLIM3 mRNA CTD PMID:20003209 NCBI chr18:57,126,534...57,245,965
Ensembl chr18:57,128,399...57,245,666
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
decreases phosphorylation
increases phosphorylation
ISO
EXP
triacsin C inhibits the reaction [Isoproterenol results in increased phosphorylation of ACACA protein]
Isoproterenol results in decreased phosphorylation of ACACA protein
CTD PMID:18390901 PMID:27491814 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain multiple interactions
decreases expression
EXP Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]] CTD PMID:25045214 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases activity
multiple interactions
decreases expression
EXP Isoproterenol results in decreased activity of ACADM protein
Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]]
CTD PMID:19826179 PMID:25045214 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression ISO
EXP
Isoproterenol results in increased expression of ACE2 mRNA
Isoproterenol results in increased expression of ACE2 protein
CTD PMID:20003209 PMID:20409916 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acer2 alkaline ceramidase 2 increases expression ISO Isoproterenol results in increased expression of ACER2 mRNA CTD PMID:20003209 NCBI chr 5:105,230,540...105,279,732
Ensembl chr 5:105,230,580...105,279,731
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions ISO [Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA; EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of ACTA1 mRNA] CTD PMID:10710348 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
decreases expression
ISO
EXP
Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA]
Isoproterenol results in increased expression of ACTA2 mRNA; Isoproterenol results in increased expression of ACTA2 protein
CTD PMID:18089841 PMID:20003209 PMID:24945829 PMID:28526319 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actb actin, beta decreases expression ISO Isoproterenol results in decreased expression of ACTB mRNA CTD PMID:20003209 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Actg2 actin gamma 2, smooth muscle increases expression ISO Isoproterenol results in increased expression of ACTG2 mRNA CTD PMID:21335049 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Ada adenosine deaminase multiple interactions
increases expression
ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA] CTD PMID:18089841 PMID:20003209 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Adam22 ADAM metallopeptidase domain 22 increases expression ISO Isoproterenol results in increased expression of ADAM22 mRNA CTD PMID:20003209 NCBI chr 4:22,864,485...23,002,969
Ensembl chr 4:22,859,622...22,996,645
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 increases expression EXP Isoproterenol results in increased expression of ADAM8 mRNA CTD PMID:20211217 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Adamtsl2 ADAMTS-like 2 increases expression ISO Isoproterenol results in increased expression of ADAMTSL2 mRNA CTD PMID:20003209 NCBI chr 3:5,624,473...5,654,890
Ensembl chr 3:5,624,506...5,654,910
JBrowse link
G Adamtsl4 ADAMTS-like 4 increases expression ISO Isoproterenol results in increased expression of ADAMTSL4 mRNA CTD PMID:20003209 NCBI chr 2:197,803,572...197,815,058
Ensembl chr 2:197,803,584...197,814,808
JBrowse link
G Adcy5 adenylate cyclase 5 increases response to substance
multiple interactions
ISO ADCY5 protein results in increased susceptibility to Isoproterenol
[ADCY5 protein results in increased susceptibility to Isoproterenol] which results in decreased expression of SOD2 protein; SOD2 protein inhibits the reaction [ADCY5 protein results in increased susceptibility to Isoproterenol]
CTD PMID:12869393 PMID:23536361 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy6 adenylate cyclase 6 affects response to substance ISO ADCY6 protein affects the susceptibility to Isoproterenol CTD PMID:12393090 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcy9 adenylate cyclase 9 multiple interactions ISO [Isoproterenol co-treated with Miconazole] results in increased activity of ADCY9 protein alternative form CTD PMID:30607468 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Add3 adducin 3 decreases expression ISO Isoproterenol results in decreased expression of ADD3 mRNA CTD PMID:21335049 NCBI chr 1:273,854,195...273,961,982
Ensembl chr 1:273,854,248...273,961,982
JBrowse link
G Adgrd1 adhesion G protein-coupled receptor D1 increases expression ISO Isoproterenol results in increased expression of ADGRD1 mRNA CTD PMID:20003209 NCBI chr12:31,134,806...31,249,594
Ensembl chr12:31,136,741...31,249,118
JBrowse link
G Adgrf5 adhesion G protein-coupled receptor F5 increases expression ISO Isoproterenol results in increased expression of ADGRF5 mRNA CTD PMID:20003209 NCBI chr 9:20,091,121...20,195,706
Ensembl chr 9:20,091,099...20,195,566
JBrowse link
G Adgrl4 adhesion G protein-coupled receptor L4 increases expression ISO Isoproterenol results in increased expression of ADGRL4 mRNA CTD PMID:20003209 NCBI chr 2:256,609,787...256,724,642
Ensembl chr 2:256,609,787...256,724,641
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) increases expression ISO Isoproterenol results in increased expression of ADH1 mRNA CTD PMID:20003209 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adm adrenomedullin multiple interactions
increases expression
EXP [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM mRNA; [Phenylephrine co-treated with Isoproterenol] results in increased expression of ADM protein; ADM protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; CALCA protein inhibits the reaction [Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]]; Isoproterenol promotes the reaction [ADM protein results in increased abundance of Cyclic AMP]
Isoproterenol results in increased expression of ADM mRNA; Isoproterenol results in increased expression of ADM protein
CTD PMID:12732346 PMID:17250927 PMID:17306419 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
decreases expression
ISO ADRA1B protein affects the reaction [Isoproterenol results in increased abundance of Cyclic AMP]
Isoproterenol results in decreased expression of ADRA1B mRNA
CTD PMID:12649302 PMID:20003209 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
decreases expression
increases phosphorylation
increases activity
affects response to substance
increases uptake
ISO
EXP
[Isoproterenol binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; carvedilol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; CGP 12177 inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; CGP 20712A inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]; Isoproterenol binds to and results in increased activity of ADRB1 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB1 protein]; Isoproterenol promotes the reaction [ADRB1 protein binds to ARRB2 protein]; Isoproterenol promotes the reaction [ADRB1 protein results in increased abundance of Cyclic AMP]; Isoproterenol promotes the reaction [ADRB1 protein results in increased uptake of EGFR protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of ADRB1 protein]
Isoproterenol results in decreased expression of ADRB1 mRNA
Isoproterenol results in increased phosphorylation of ADRB1 protein
[ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol
ADRB1 protein polymorphism affects the susceptibility to Isoproterenol
Isoproterenol results in increased uptake of ADRB1 protein
ADRB1 protein promotes the reaction [Isoproterenol results in decreased expression of NPPA protein]; ADRB1 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]; AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; Isoproterenol binds to and results in increased activity of ADRB1 protein; Isoproterenol inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Metoprolol inhibits the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]
Isoproterenol results in decreased expression of ADRB1; Isoproterenol results in decreased expression of ADRB1 mRNA
CTD PMID:1312942 PMID:8096834 PMID:8723169 PMID:11159692 PMID:12761341 PMID:12963636 PMID:14502278 PMID:14730417 PMID:15627480 PMID:16731636 PMID:17200720 PMID:17350036 PMID:18194989 PMID:18378355 PMID:18787115 PMID:20003209 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases activity
affects expression
increases uptake
decreases expression
increases phosphorylation
increases expression
ISO
EXP
4-(1H-imidazol-4-ylmethyl)piperidine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Isoproterenol results in increased activity of ADRB2 protein] which results in increased chemical synthesis of Cyclic AMP; [Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol; Atenolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; clobenpropit promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Cobalt promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Histamine promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; imidazole promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; Isoproterenol binds to and results in increased activity of ADRB2 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Isoproterenol promotes the reaction [ADRB2 protein binds to ARRB2 protein]; Ketotifen inhibits the reaction [[Terbutaline binds to and results in increased activity of ADRB2 protein] which results in decreased susceptibility to Isoproterenol]; Propranolol inhibits the reaction [[Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]; Zinc promotes the reaction [Isoproterenol binds to and results in increased activity of ADRB2 protein]
Isoproterenol affects the expression of ADRB2 mRNA
Isoproterenol results in increased uptake of ADRB2 protein
[Isoproterenol results in increased activity of ADRB2 protein] which results in increased secretion of Histamine; ADRB2 protein promotes the reaction [Isoproterenol results in increased abundance of Cyclic AMP]
Isoproterenol results in decreased expression of ADRB2; Isoproterenol results in decreased expression of ADRB2 mRNA
[GNA15 protein results in increased susceptibility to Isoproterenol] which results in increased activity of ADRB2 protein; ADRB2 protein affects the reaction [Isoproterenol results in increased expression of IL18 mRNA]; CAV1 protein promotes the reaction [Isoproterenol results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Isoproterenol results in increased activity of ADRB2 protein]
Isoproterenol results in increased phosphorylation of ADRB2 protein
Isoproterenol results in increased expression of ADRB2 mRNA
CTD PMID:9875846 PMID:10226872 PMID:10516654 PMID:11164953 PMID:11752207 PMID:12920204 PMID:12963636 PMID:14730417 PMID:15178407 PMID:16036225 PMID:16980553 PMID:17196553 PMID:17350036 PMID:17925438 PMID:18378355 PMID:18820136 PMID:19483313 PMID:21177286 PMID:21629661 PMID:24705868 PMID:27825928 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases activity
increases expression
ISO
EXP
[Isoproterenol binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Isoproterenol binds to and results in increased activity of ADRB3 protein; Isoproterenol inhibits the reaction [cyanopindolol binds to ADRB3 protein]; L 748,337 inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]
Isoproterenol results in increased expression of ADRB3 mRNA; Isoproterenol results in increased expression of ADRB3 protein
[ADRB3 affects the expression of ADRB1 mRNA] which affects the susceptibility to Isoproterenol
3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased activity of ADRB3 protein]; 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Isoproterenol results in increased expression of ADRB3 protein]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 mRNA]; BRL 37344 promotes the reaction [Isoproterenol results in increased expression of ADRB3 protein]; Isoproterenol binds to and results in increased activity of ADRB3 protein
CTD PMID:1682311 PMID:7815362 PMID:11159692 PMID:14730417 PMID:15009959 PMID:17622774 PMID:18553954 PMID:18820136 PMID:20654104 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Aen apoptosis enhancing nuclease decreases expression ISO Isoproterenol results in decreased expression of AEN mRNA CTD PMID:20003209 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
JBrowse link
G Agbl5 AGBL carboxypeptidase 5 decreases expression ISO Isoproterenol results in decreased expression of AGBL5 mRNA CTD PMID:20003209 NCBI chr 6:26,837,299...26,857,234
Ensembl chr 6:26,838,036...26,855,658
JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
ISO
EXP
adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; ICI 118551 inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]; Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]; Propranolol inhibits the reaction [Isoproterenol promotes the reaction [Dexamethasone results in increased expression of AGT protein]]
Isoproterenol results in increased expression of AGT protein
AGT affects the reaction [Isoproterenol results in decreased expression of ADRB1 mRNA]; AGT affects the reaction [Isoproterenol results in decreased expression of GRK2 mRNA]; AGT inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Quinapril promotes the reaction [Isoproterenol results in increased expression of AGT protein]; Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; trandolapril inhibits the reaction [Isoproterenol results in increased expression of AGT protein]
Isoproterenol results in increased expression of AGT mRNA; Isoproterenol results in increased expression of AGT protein
Propranolol inhibits the reaction [Isoproterenol results in increased expression of AGT protein]
CTD PMID:1534315 PMID:1653766 PMID:7843740 PMID:11709406 PMID:16731636 PMID:19023134 PMID:19483313 PMID:20003209 PMID:20409916 PMID:24117263 PMID:27890915 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Isoproterenol results in decreased expression of AGTR1A mRNA CTD PMID:17350036 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Ahcy adenosylhomocysteinase increases expression ISO Isoproterenol results in increased expression of AHCY mRNA CTD PMID:20003209 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Ahnak2 AHNAK nucleoprotein 2 increases expression ISO Isoproterenol results in increased expression of AHNAK2 mRNA CTD PMID:20003209 NCBI chr 6:137,335,273...137,380,219 JBrowse link
G Ahr aryl hydrocarbon receptor increases expression
decreases expression
ISO
EXP
Isoproterenol results in increased expression of AHR mRNA
Isoproterenol results in decreased expression of AHR mRNA
CTD PMID:24286936 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahsg alpha-2-HS-glycoprotein increases expression ISO Isoproterenol results in increased expression of AHSG mRNA CTD PMID:20003209 PMID:21335049 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression ISO Isoproterenol results in decreased expression of AIF1 mRNA CTD PMID:20003209 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Ak4 adenylate kinase 4 decreases expression ISO Isoproterenol results in decreased expression of AK4 mRNA CTD PMID:20003209 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akap1 A-kinase anchoring protein 1 decreases expression ISO Isoproterenol results in decreased expression of AKAP1 mRNA CTD PMID:20003209 NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276
JBrowse link
G Akap13 A-kinase anchoring protein 13 increases expression ISO Isoproterenol results in increased expression of AKAP13 mRNA CTD PMID:20003209 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
decreases expression
ISO
EXP
Isoproterenol results in increased phosphorylation of AKT1 protein
2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; [PDE3B protein co-treated with AKT1 protein] inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]
Isoproterenol results in decreased expression of AKT1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; swietenine inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:15178407 PMID:15618457 PMID:15951400 PMID:16716347 PMID:17623046 PMID:18806606 PMID:19167487 PMID:20003209 PMID:31009642 PMID:32686902 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression ISO Isoproterenol results in decreased expression of ALDH2 mRNA CTD