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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5beta-cholestane
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Accession:CHEBI:35517 term browser browse the term
Definition:A cholestane that has formula C27H48.
Synonyms:related_synonym: Formula=C27H48;   InChI=1S/C27H48/c1-19(2)9-8-10-20(3)23-14-15-24-22-13-12-21-11-6-7-17-26(21,4)25(22)16-18-27(23,24)5/h19-25H,6-18H2,1-5H3/t20-,21+,22+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=XIIAYQZJNBULGD-CJPSHIORSA-N;   SMILES=[H][C@@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCCC(C)C;   beta-cholestane;   coprostane;   pseudocholestane
 xref: Beilstein:2051807;   CAS:481-20-9;   LIPID_MAPS_instance:LMST01010085


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20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 increases activity ISO Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression
ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA
CTD PMID:29126784 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone
CTD PMID:26048653 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      atom 19784
        nonmetal atom 19659
          carbon atom 19563
            organic molecular entity 19563
              lipid 16977
                steroid 12788
                  steroid fundamental parent 12403
                    cholestane 334
                      5beta-cholestane 6
                        2,22,25-trideoxyecdysone 0
                        2-deoxyecdysone 0
                        25-deoxyecdysone 0
                        3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid + 0
                        3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 0
                        3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid + 0
                        3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al + 0
                        3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid + 0
                        3alpha,7alpha-dihydroxy-5beta-cholestan-26-al 0
                        3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid + 0
                        3alpha,7beta-dihydroxy-5beta-cholest-24-en-26-oic acid 0
                        5,6beta-epoxy-5beta-cholestane 0
                        5b-Cholestane-3a,7a,12a,23-tetrol 0
                        5b-cholestane-3a,7a,12a,23S,25-pentol 0
                        5beta-cholest-7-ene 0
                        5beta-cholestan-3-one 0
                        5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol + 0
                        5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol + 0
                        5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 0
                        5beta-cholestane-3alpha,7alpha,12alpha-triol 0
                        5beta-cholestane-3alpha,7alpha,24,26-tetrol + 0
                        5beta-cholestane-3alpha,7alpha,24-triol + 0
                        5beta-cholestane-3alpha,7alpha,26-triol 0
                        5beta-cholestane-3alpha,7alpha-diol 0
                        5beta-cyprinol + 0
                        5beta-scymnol + 0
                        7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one + 0
                        7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one 0
                        7alpha,12alpha-dihydroxy-5beta-cholestan-3-one 0
                        7alpha,24-dihydroxy-5beta-cholestan-3-one + 0
                        7alpha,26-dihydroxy-5beta-cholestan-3-one 0
                        7alpha-hydroxy-5beta-cholestan-3-one 0
                        cholesterol beta-epoxide 0
                        coprostanol + 0
                        ecdysone + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic polycyclic compound 16384
                                  steroid 12788
                                    steroid fundamental parent 12403
                                      cholestane 334
                                        5beta-cholestane 6
                                          2,22,25-trideoxyecdysone 0
                                          2-deoxyecdysone 0
                                          25-deoxyecdysone 0
                                          3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid + 0
                                          3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + 0
                                          3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid + 0
                                          3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-al + 0
                                          3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oic acid + 0
                                          3alpha,7alpha-dihydroxy-5beta-cholestan-26-al 0
                                          3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid + 0
                                          3alpha,7beta-dihydroxy-5beta-cholest-24-en-26-oic acid 0
                                          5,6beta-epoxy-5beta-cholestane 0
                                          5b-Cholestane-3a,7a,12a,23-tetrol 0
                                          5b-cholestane-3a,7a,12a,23S,25-pentol 0
                                          5beta-cholest-7-ene 0
                                          5beta-cholestan-3-one 0
                                          5beta-cholestane-3alpha,7alpha,12alpha,24,26-pentol + 0
                                          5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol + 0
                                          5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 0
                                          5beta-cholestane-3alpha,7alpha,12alpha-triol 0
                                          5beta-cholestane-3alpha,7alpha,24,26-tetrol + 0
                                          5beta-cholestane-3alpha,7alpha,24-triol + 0
                                          5beta-cholestane-3alpha,7alpha,26-triol 0
                                          5beta-cholestane-3alpha,7alpha-diol 0
                                          5beta-cyprinol + 0
                                          5beta-scymnol + 0
                                          7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one + 0
                                          7alpha,12alpha,26-trihydroxy-5beta-cholestan-3-one 0
                                          7alpha,12alpha-dihydroxy-5beta-cholestan-3-one 0
                                          7alpha,24-dihydroxy-5beta-cholestan-3-one + 0
                                          7alpha,26-dihydroxy-5beta-cholestan-3-one 0
                                          7alpha-hydroxy-5beta-cholestan-3-one 0
                                          cholesterol beta-epoxide 0
                                          coprostanol + 0
                                          ecdysone + 6
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