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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cholestane
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Accession:CHEBI:35516 term browser browse the term
Definition:A steroid fundamental parent that has formula C27H48.
Synonyms:related_synonym: Formula=C27H48;   InChI=1S/C27H48/c1-19(2)9-8-10-20(3)23-14-15-24-22-13-12-21-11-6-7-17-26(21,4)25(22)16-18-27(23,24)5/h19-25H,6-18H2,1-5H3/t20-,21?,22+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=XIIAYQZJNBULGD-LDHZKLTISA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4CCCC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
 xref: Beilstein:5334741;   CAS:14982-53-7;   LIPID_MAPS_instance:LMST01010000;   Wikipedia:Cholestane

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(24S)-24-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO 24-hydroxycholesterol results in increased expression of ABCA1 mRNA; 24-hydroxycholesterol results in increased expression of ABCA1 protein CTD PMID:15148325 PMID:19126211 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO 24-hydroxycholesterol results in increased expression of ABCG1 protein CTD PMID:19126211 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing		 ISO 24-hydroxycholesterol affects the metabolism of and results in increased activity of APP protein; 24-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein
24-hydroxycholesterol results in increased metabolism of APP protein		 CTD PMID:15148325 PMID:17532301 PMID:19126211 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO 24-hydroxycholesterol results in increased expression of CCL2 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA]		 CTD PMID:24802026 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO 24-hydroxycholesterol results in increased expression of CD36 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]		 CTD PMID:24802026 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases abundance ISO CYP27A1 protein results in decreased abundance of 24-hydroxycholesterol CTD PMID:12119285 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 increases metabolic processing ISO CYP39A1 protein results in increased metabolism of 24-hydroxycholesterol CTD PMID:10748047 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 affects abundance
increases chemical synthesis
increases metabolic processing		 ISO CYP46A1 gene SNP affects the abundance of 24-hydroxycholesterol
CYP46A1 protein results in increased chemical synthesis of 24-hydroxycholesterol
CYP46A1 protein results in increased metabolism of 24-hydroxycholesterol		 CTD PMID:14640697 PMID:19286353 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing ISO CYP7A1 protein results in increased metabolism of 24-hydroxycholesterol CTD PMID:11013305 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 24-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:17873880 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 24-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:17873880 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity ISO 24-hydroxycholesterol results in decreased activity of HMGCR protein CTD PMID:7751816 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Itgb1 integrin subunit beta 1 increases expression
multiple interactions		 ISO 24-hydroxycholesterol results in increased expression of ITGB1 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]		 CTD PMID:24802026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO 24-hydroxycholesterol results in increased expression of MMP9 mRNA
Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of MMP9 mRNA]		 CTD PMID:24802026 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO [24-hydroxycholesterol co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA CTD PMID:23732298 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions
increases expression		 ISO Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of PTGES mRNA] CTD PMID:24802026 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO 24-hydroxycholesterol results in increased expression of PTGS2 protein
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein		 CTD PMID:24802026 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO 24-hydroxycholesterol results in increased expression of and results in increased phosphorylation of TH protein CTD PMID:19014385 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [24-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [24-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA] CTD PMID:24802026 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
(25R)-cholest-5-ene-3beta,26-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 ISO
EXP		 Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]
27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 protein
[Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA		 CTD PMID:15148325 PMID:17088262 PMID:18356535 PMID:18841091 PMID:20056921 PMID:28167099 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ABCG1 protein CTD PMID:17088262 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoe apolipoprotein E increases expression EXP 27-hydroxycholesterol results in increased expression of APOE mRNA; 27-hydroxycholesterol results in increased expression of APOE protein CTD PMID:28167099 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases secretion
increases expression		 ISO 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein
27-hydroxycholesterol results in decreased secretion of APP protein alternative form
27-hydroxycholesterol results in increased expression of APP protein alternative form		 CTD PMID:15148325 PMID:19126211 PMID:19158428 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP 27-hydroxycholesterol results in decreased expression of ARC protein CTD PMID:18503570 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Bace1 beta-secretase 1 increases expression ISO 27-hydroxycholesterol results in increased expression of BACE1 protein CTD PMID:19126211 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA] CTD PMID:24802026 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
increases secretion		 ISO 27-hydroxycholesterol results in increased expression of CCL3 mRNA
27-hydroxycholesterol results in increased secretion of CCL3 protein		 CTD PMID:24370436 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of CCL4 protein
27-hydroxycholesterol results in increased expression of CCL4 mRNA		 CTD PMID:24370436 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA] CTD PMID:17872378 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CD36 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]		 CTD PMID:24802026 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity
multiple interactions		 ISO 27-hydroxycholesterol results in decreased activity of CES1 protein
27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin]		 CTD PMID:19761868 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CXCL12 mRNA
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CXCL12 mRNA]		 CTD PMID:17872378 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases abundance
multiple interactions
increases chemical synthesis		 ISO
EXP		 CYP27A1 protein results in increased abundance of 27-hydroxycholesterol
[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol
CYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol		 CTD PMID:8496670 PMID:9215552 PMID:9660774 PMID:11408283 PMID:11714861 PMID:12119285 PMID:12531903 PMID:14622972 PMID:15708352 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing ISO
EXP		 CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases hydroxylation
increases metabolic processing
increases abundance		 ISO CYP7B1 protein results in increased hydroxylation of 27-hydroxycholesterol
CYP7B1 protein results in increased metabolism of 27-hydroxycholesterol
CYP7B1 gene mutant form results in increased abundance of 27-hydroxycholesterol		 CTD PMID:10588945 PMID:10748047 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO 27-hydroxycholesterol results in increased expression of E2F1 mRNA CTD PMID:17872378 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 27-hydroxycholesterol results in decreased expression of ERBB4 mRNA CTD PMID:17872378 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects response to substance
increases degradation		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein]
ESR1 protein affects the susceptibility to 27-hydroxycholesterol
ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]
27-hydroxycholesterol results in increased degradation of ESR1 protein		 CTD PMID:17872378 PMID:17873880 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects response to substance		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
ESR2 protein affects the susceptibility to 27-hydroxycholesterol
ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]		 CTD PMID:17872378 PMID:17873880 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of GRIN1 protein CTD PMID:18503570 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases phosphorylation EXP 27-hydroxycholesterol results in decreased phosphorylation of GRIN2A protein CTD PMID:18503570 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 27-hydroxycholesterol results in increased expression of HIF1A protein CTD PMID:27856279 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity
decreases expression
multiple interactions		 ISO
EXP		 27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 27-hydroxycholesterol results in decreased activity of HMGCR protein
27-hydroxycholesterol results in decreased expression of HMGCR mRNA; 27-hydroxycholesterol results in decreased expression of HMGCR protein
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]		 CTD PMID:7749852 PMID:7751816 PMID:7788503 PMID:9059514 PMID:11408283 PMID:18024962 PMID:28167099 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ICAM1 mRNA CTD PMID:19426978 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 27-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:11851725 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased secretion of IL6 protein
27-hydroxycholesterol results in increased expression of IL6 mRNA
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]		 CTD PMID:11851725 PMID:28739487 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA] CTD PMID:24802026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases metabolic processing ISO LCAT protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:7744831 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Ldlr low density lipoprotein receptor decreases activity
decreases expression		 ISO
EXP		 27-hydroxycholesterol results in decreased activity of LDLR protein
27-hydroxycholesterol results in decreased expression of LDLR mRNA; 27-hydroxycholesterol results in decreased expression of LDLR protein		 CTD PMID:8820113 PMID:28167099 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions ISO LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] CTD PMID:23362264 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of MMP9 mRNA
Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA]		 CTD PMID:24802026 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] CTD PMID:17873880 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression
multiple interactions		 ISO 27-hydroxycholesterol results in decreased expression of NOS3 mRNA
27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]		 CTD PMID:17873880 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 affects abundance ISO NPC1 protein affects the abundance of 27-hydroxycholesterol CTD PMID:18483620 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP 27-hydroxycholesterol results in increased expression of NR1H3 mRNA; 27-hydroxycholesterol results in increased expression of NR1H3 protein CTD PMID:28167099 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases activity
multiple interactions		 ISO 27-hydroxycholesterol results in increased activity of NR5A1 protein
27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9144161 PMID:9804848 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PGR mRNA; 27-hydroxycholesterol results in increased expression of PGR protein
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]		 CTD PMID:17872378 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 27-hydroxycholesterol results in increased expression of PPARG mRNA; 27-hydroxycholesterol results in increased expression of PPARG protein CTD PMID:28167099 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGES mRNA
Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]		 CTD PMID:24802026 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGS2 protein
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein		 CTD PMID:24802026 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Sele selectin E increases expression ISO 27-hydroxycholesterol results in increased expression of SELE mRNA CTD PMID:19426978 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 decreases activity ISO 27-hydroxycholesterol results in decreased activity of SMPD2 protein CTD PMID:15261762 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120 		JBrowse link
G Snca synuclein alpha increases expression ISO 27-hydroxycholesterol results in increased expression of SNCA mRNA; 27-hydroxycholesterol results in increased expression of SNCA protein CTD PMID:18841091 PMID:19014385 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity EXP 27-hydroxycholesterol results in decreased activity of SRC protein CTD PMID:18503570 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of SREBF1 mRNA; 27-hydroxycholesterol results in decreased expression of SREBF1 protein CTD PMID:28167099 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases abundance
increases expression		 ISO
EXP		 27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]
STAR protein results in increased abundance of 27-hydroxycholesterol
27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein]
27-hydroxycholesterol results in increased expression of STAR mRNA; 27-hydroxycholesterol results in increased expression of STAR protein		 CTD PMID:9804848 PMID:12368294 PMID:15863358 PMID:20083572 PMID:23362264 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]		 CTD PMID:27856279 PMID:28739487 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression		 ISO 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of TFF1 mRNA] CTD PMID:17872378 PMID:27856279 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol CTD PMID:15708352 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of TLR4 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]		 CTD PMID:24802026 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of VCAM1 mRNA CTD PMID:19426978 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases secretion
increases expression		 ISO Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein] CTD PMID:27856279 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
(5alpha)-cholestan-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases secretion ISO CYP27A1 protein results in increased secretion of Cholestanol CTD PMID:12117727 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of Cholestanol CTD PMID:14640697 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [Cholestanol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of Cholestanol CTD PMID:21839837 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
20-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA CTD PMID:21610156 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing EXP
ISO		 CYP7A1 protein results in increased metabolism of 20-hydroxycholesterol CTD PMID:10882719 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [20-hydroxycholesterol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241 		JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions ISO [20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter] CTD PMID:21610156 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO [20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] promotes the reaction [NR5A1 protein binds to MC2R promoter]; [NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased abundance of Progesterone; [NR5A1 protein co-treated with 20-hydroxycholesterol co-treated with Tretinoin co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11A1 mRNA CTD PMID:21610156 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
20-hydroxyecdysone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein] CTD PMID:26048653 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Casp3 caspase 3 increases activity ISO Ecdysterone results in increased activity of CASP3 protein CTD PMID:29126784 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein] CTD PMID:26048653 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:26048653 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression
increases expression		 ISO Ecdysterone results in decreased expression of HSPA5 protein
Ecdysterone results in increased expression of HSPA5 mRNA		 CTD PMID:29126784 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]
NFE2L2 results in increased susceptibility to Ecdysterone		 CTD PMID:26048653 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
25-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression
multiple interactions		 ISO
EXP		 25-hydroxycholesterol results in increased expression of ABCA1 mRNA
[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA; [25-hydroxycholesterol co-treated with alitretinoin] results in increased expression of ABCA1 protein; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]
[Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNA		 CTD PMID:12595494 PMID:16023994 PMID:17526932 PMID:19260826 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO 25-hydroxycholesterol results in increased expression of ABCG1 mRNA CTD PMID:31011801 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 EXP 25-hydroxycholesterol results in increased expression of ACTA2 mRNA
15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of ACTA2 mRNA]; alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of ACTA2 mRNA]		 CTD PMID:17161435 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Adipor1 adiponectin receptor 1 multiple interactions
decreases expression		 ISO [25-hydroxycholesterol co-treated with alitretinoin] results in decreased expression of ADIPOR1 mRNA
25-hydroxycholesterol results in decreased expression of ADIPOR1 mRNA		 CTD PMID:16023994 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; BAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP3 protein] CTD PMID:25845326 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 EXP 25-hydroxycholesterol results in increased activity of CASP8 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; BAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP8 protein]		 CTD PMID:25845326 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 EXP 25-hydroxycholesterol results in increased activity of CASP9 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; BAY 11-7085 inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [25-hydroxycholesterol results in increased activity of CASP9 protein]		 CTD PMID:25845326 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP 25-hydroxycholesterol results in increased expression of CDKN1B mRNA CTD PMID:17161435 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cnn1 calponin 1 multiple interactions
increases expression		 EXP 15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA]; alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA] CTD PMID:17161435 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions
increases chemical synthesis		 ISO [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol
CYP27A1 protein results in increased chemical synthesis of 25-hydroxycholesterol		 CTD PMID:8078928 PMID:17890683 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing ISO
EXP		 CYP7A1 protein results in increased metabolism of 25-hydroxycholesterol CTD PMID:10882719 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases metabolic processing
increases abundance		 ISO CYP7B1 protein results in increased metabolism of 25-hydroxycholesterol
CYP7B1 gene mutant form results in increased abundance of 25-hydroxycholesterol		 CTD PMID:10748047 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 25-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:17873880 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 25-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:17873880 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Fads1 fatty acid desaturase 1 multiple interactions
decreases expression		 ISO 25-hydroxycholesterol inhibits the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]
25-hydroxycholesterol results in decreased expression of FADS1 mRNA		 CTD PMID:17655842 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO 25-hydroxycholesterol results in increased expression of FAS mRNA CTD PMID:19260826 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fhl1 four and a half LIM domains 1 multiple interactions
increases expression		 EXP 15-deoxyprostaglandin J2 inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Brefeldin A inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Cycloheximide promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Dactinomycin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]; Genistein inhibits the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] CTD PMID:17161435 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
decreases activity		 ISO
EXP		 [25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein; [25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [25-hydroxycholesterol results in decreased activity of HMGCR protein]
25-hydroxycholesterol results in decreased expression of HMGCR protein
25-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 25-hydroxycholesterol results in decreased activity of HMGCR protein
25-hydroxycholesterol results in decreased expression of HMGCR mRNA; 25-hydroxycholesterol results in decreased expression of HMGCR protein		 CTD PMID:7749852 PMID:7751816 PMID:9059514 PMID:12477733 PMID:18024962 PMID:19260826 PMID:21944868 PMID:27447558 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases expression		 ISO 25-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
25-hydroxycholesterol results in increased secretion of IL1B protein
25-hydroxycholesterol results in increased expression of IL1B mRNA		 CTD PMID:11851725 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions		 ISO
EXP		 25-hydroxycholesterol results in increased secretion of IL6 protein
25-hydroxycholesterol inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
25-hydroxycholesterol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]		 CTD PMID:11851725 PMID:27052460 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inha inhibin subunit alpha increases expression EXP 25-hydroxycholesterol results in increased expression of INHA mRNA; 25-hydroxycholesterol results in increased expression of INHA protein CTD PMID:19464342 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400 		JBrowse link
G Inhba inhibin subunit beta A increases expression
decreases expression		 EXP 25-hydroxycholesterol results in increased expression of INHBA mRNA
25-hydroxycholesterol results in decreased expression of INHBA protein		 CTD PMID:19464342 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496 		JBrowse link
G Inhbb inhibin subunit beta B increases expression EXP 25-hydroxycholesterol results in increased expression of INHBB mRNA; 25-hydroxycholesterol results in increased expression of INHBB protein CTD PMID:19464342 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO 25-hydroxycholesterol results in decreased expression of INSIG1 mRNA CTD PMID:19260826 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression
multiple interactions		 ISO 25-hydroxycholesterol results in decreased expression of LDLR mRNA; 25-hydroxycholesterol results in decreased expression of LDLR protein
25-hydroxycholesterol inhibits the reaction [[Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]; 25-hydroxycholesterol inhibits the reaction [Resveratrol results in increased expression of LDLR mRNA]; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein]; LDLR gene mutant form results in increased susceptibility to [25-hydroxycholesterol co-treated with Cholesterol]		 CTD PMID:12477733 PMID:19260826 PMID:22153697 PMID:27447558 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lpl lipoprotein lipase decreases expression
decreases activity		 ISO 25-hydroxycholesterol results in decreased expression of LPL mRNA
25-hydroxycholesterol results in decreased activity of LPL protein		 CTD PMID:8567968 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases stability ISO 25-hydroxycholesterol results in increased stability of MARCHF6 protein CTD PMID:30545937 NCBI chr 2:84,533,546...84,608,743
Ensembl chr 2:84,536,669...84,608,712 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO 25-hydroxycholesterol results in increased expression of NOS2 mRNA CTD PMID:12085989 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO 25-hydroxycholesterol results in decreased expression of NOS3 mRNA CTD PMID:19426978 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases activity
multiple interactions		 ISO 25-hydroxycholesterol results in increased activity of NR1H3 protein
[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA; [25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; SULT2B1 protein inhibits the reaction [25-hydroxycholesterol results in increased activity of NR1H3 protein]		 CTD PMID:9603267 PMID:12595494 PMID:27052460 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases activity
multiple interactions		 ISO 25-hydroxycholesterol results in increased activity of NR5A1 protein
25-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9144161 PMID:9804848 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] CTD PMID:12595494 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol] CTD PMID:12595494 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO 25-hydroxycholesterol binds to RORA protein CTD PMID:31195007 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212 		JBrowse link
G Rorc RAR-related orphan receptor C affects binding
multiple interactions		 ISO 25-hydroxycholesterol binds to RORC protein
bisphenol A analog inhibits the reaction [25-hydroxycholesterol binds to RORC protein]; TO-901317 inhibits the reaction [25-hydroxycholesterol binds to RORC protein]		 CTD PMID:22659100 PMID:31195007 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO 25-hydroxycholesterol results in decreased expression of SCD protein CTD PMID:27447558 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO 25-hydroxycholesterol results in increased expression of SREBF1 protein
[25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF1 protein		 CTD PMID:19260826 PMID:27324795 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 decreases activity
multiple interactions		 ISO 25-hydroxycholesterol results in decreased activity of SREBF2 protein
25-hydroxycholesterol inhibits the reaction [[Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein] which results in increased expression of LDLR mRNA]; 25-hydroxycholesterol inhibits the reaction [Resveratrol results in increased activity of and results in increased cleavage of SREBF2 protein]; 25-hydroxycholesterol inhibits the reaction [Resveratrol results in increased expression of SREBF2 protein modified form]; [25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF2 protein; Clozapine inhibits the reaction [25-hydroxycholesterol results in decreased activity of SREBF2 protein]		 CTD PMID:17052361 PMID:22153697 PMID:27324795 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO 25-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein] CTD PMID:9804848 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP 25-hydroxycholesterol inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein] CTD PMID:27052460 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 multiple interactions ISO SULT2B1 protein inhibits the reaction [25-hydroxycholesterol results in increased activity of NR1H3 protein]
SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 25-hydroxycholesterol]		 CTD PMID:27052460 NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508 		JBrowse link
G Tnfsf15 TNF superfamily member 15 increases expression ISO 25-hydroxycholesterol results in increased expression of TNFSF15 mRNA CTD PMID:19426978 NCBI chr 5:79,553,935...79,569,974
Ensembl chr 5:79,553,742...79,570,073 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO 25-hydroxycholesterol results in increased expression of VCAM1 mRNA CTD PMID:19426978 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
26-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression
multiple interactions		 ISO
EXP		 27-hydroxycholesterol results in increased expression of ABCA1 mRNA; 27-hydroxycholesterol results in increased expression of ABCA1 protein
Docosahexaenoic Acids inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Linoleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]; Oleic Acid inhibits the reaction [27-hydroxycholesterol results in increased expression of ABCA1 mRNA]
[Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA		 CTD PMID:15148325 PMID:17088262 PMID:18356535 PMID:18841091 PMID:20056921 PMID:28167099 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ABCG1 protein CTD PMID:17088262 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]] CTD PMID:20083572 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoe apolipoprotein E increases expression EXP 27-hydroxycholesterol results in increased expression of APOE mRNA; 27-hydroxycholesterol results in increased expression of APOE protein CTD PMID:28167099 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases expression
decreases secretion		 ISO 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein
27-hydroxycholesterol results in increased expression of APP protein alternative form
27-hydroxycholesterol results in decreased secretion of APP protein alternative form		 CTD PMID:15148325 PMID:19126211 PMID:19158428 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein decreases expression EXP 27-hydroxycholesterol results in decreased expression of ARC protein CTD PMID:18503570 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Bace1 beta-secretase 1 increases expression ISO 27-hydroxycholesterol results in increased expression of BACE1 protein CTD PMID:19126211 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CCL2 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA]		 CTD PMID:24802026 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
increases secretion		 ISO 27-hydroxycholesterol results in increased expression of CCL3 mRNA
27-hydroxycholesterol results in increased secretion of CCL3 protein		 CTD PMID:24370436 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of CCL4 protein
27-hydroxycholesterol results in increased expression of CCL4 mRNA		 CTD PMID:24370436 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CCN5 mRNA
Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CCN5 mRNA]		 CTD PMID:17872378 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA] CTD PMID:24802026 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
decreases activity		 ISO 27-hydroxycholesterol inhibits the reaction [CES1 protein results in increased metabolism of bioresmethrin]
27-hydroxycholesterol results in decreased activity of CES1 protein		 CTD PMID:19761868 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of CXCL12 mRNA
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of CXCL12 mRNA]		 CTD PMID:17872378 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases abundance
increases chemical synthesis
multiple interactions		 ISO
EXP		 CYP27A1 protein results in increased abundance of 27-hydroxycholesterol
CYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol
[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol		 CTD PMID:8496670 PMID:9215552 PMID:9660774 PMID:11408283 PMID:11714861 PMID:12119285 PMID:12531903 PMID:14622972 PMID:15708352 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases metabolic processing ISO
EXP		 CYP7A1 protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:10882719 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases abundance
increases metabolic processing
increases hydroxylation		 ISO CYP7B1 gene mutant form results in increased abundance of 27-hydroxycholesterol
CYP7B1 protein results in increased metabolism of 27-hydroxycholesterol
CYP7B1 protein results in increased hydroxylation of 27-hydroxycholesterol		 CTD PMID:10588945 PMID:10748047 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO 27-hydroxycholesterol results in increased expression of E2F1 mRNA CTD PMID:17872378 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 27-hydroxycholesterol results in decreased expression of ERBB4 mRNA CTD PMID:17872378 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects response to substance
increases degradation		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein]
ESR1 protein affects the susceptibility to 27-hydroxycholesterol
ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]
27-hydroxycholesterol results in increased degradation of ESR1 protein		 CTD PMID:17872378 PMID:17873880 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects response to substance		 ISO 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]
ESR2 protein affects the susceptibility to 27-hydroxycholesterol
ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]		 CTD PMID:17872378 PMID:17873880 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of GRIN1 protein CTD PMID:18503570 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases phosphorylation EXP 27-hydroxycholesterol results in decreased phosphorylation of GRIN2A protein CTD PMID:18503570 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 27-hydroxycholesterol results in increased expression of HIF1A protein CTD PMID:27856279 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
decreases activity		 ISO
EXP		 [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; Dehydroepiandrosterone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]; Pregnenolone inhibits the reaction [27-hydroxycholesterol results in decreased activity of HMGCR protein]
27-hydroxycholesterol results in decreased expression of HMGCR mRNA; 27-hydroxycholesterol results in decreased expression of HMGCR protein
27-hydroxycholesterol metabolite results in decreased activity of HMGCR protein; 27-hydroxycholesterol results in decreased activity of HMGCR protein		 CTD PMID:7749852 PMID:7751816 PMID:7788503 PMID:9059514 PMID:11408283 PMID:18024962 PMID:28167099 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of ICAM1 mRNA CTD PMID:19426978 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 27-hydroxycholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:11851725 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of IL6 protein
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]		 CTD PMID:11851725 PMID:28739487 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA] CTD PMID:24802026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases metabolic processing ISO LCAT protein results in increased metabolism of 27-hydroxycholesterol CTD PMID:7744831 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Ldlr low density lipoprotein receptor decreases activity
decreases expression		 ISO
EXP		 27-hydroxycholesterol results in decreased activity of LDLR protein
27-hydroxycholesterol results in decreased expression of LDLR mRNA; 27-hydroxycholesterol results in decreased expression of LDLR protein		 CTD PMID:8820113 PMID:28167099 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions ISO LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein] CTD PMID:23362264 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of MMP9 mRNA] CTD PMID:24802026 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA] CTD PMID:17873880 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression		 ISO 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased expression of NOS3 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] CTD PMID:17873880 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 affects abundance ISO NPC1 protein affects the abundance of 27-hydroxycholesterol CTD PMID:18483620 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP 27-hydroxycholesterol results in increased expression of NR1H3 mRNA; 27-hydroxycholesterol results in increased expression of NR1H3 protein CTD PMID:28167099 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases activity
multiple interactions		 ISO 27-hydroxycholesterol results in increased activity of NR5A1 protein
27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9144161 PMID:9804848 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PGR mRNA; 27-hydroxycholesterol results in increased expression of PGR protein
fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]		 CTD PMID:17872378 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 27-hydroxycholesterol results in increased expression of PPARG mRNA; 27-hydroxycholesterol results in increased expression of PPARG protein CTD PMID:28167099 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGES mRNA
Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of PTGES mRNA]		 CTD PMID:24802026 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of PTGS2 protein
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein		 CTD PMID:24802026 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Sele selectin E increases expression ISO 27-hydroxycholesterol results in increased expression of SELE mRNA CTD PMID:19426978 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 decreases activity ISO 27-hydroxycholesterol results in decreased activity of SMPD2 protein CTD PMID:15261762 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120 		JBrowse link
G Snca synuclein alpha increases expression ISO 27-hydroxycholesterol results in increased expression of SNCA mRNA; 27-hydroxycholesterol results in increased expression of SNCA protein CTD PMID:18841091 PMID:19014385 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity EXP 27-hydroxycholesterol results in decreased activity of SRC protein CTD PMID:18503570 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP 27-hydroxycholesterol results in decreased expression of SREBF1 mRNA; 27-hydroxycholesterol results in decreased expression of SREBF1 protein CTD PMID:28167099 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions
increases expression
increases abundance		 ISO
EXP		 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR mRNA]; LIPE protein promotes the reaction [27-hydroxycholesterol results in increased expression of STAR protein]
27-hydroxycholesterol results in increased expression of STAR mRNA; 27-hydroxycholesterol results in increased expression of STAR protein
STAR protein results in increased abundance of 27-hydroxycholesterol
27-hydroxycholesterol promotes the reaction [NR5A1 protein results in increased expression of STAR protein]		 CTD PMID:9804848 PMID:12368294 PMID:15863358 PMID:20083572 PMID:23362264 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 ISO 27-hydroxycholesterol results in increased phosphorylation of STAT3 protein
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; IL6 protein affects the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]		 CTD PMID:27856279 PMID:28739487 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tff1 trefoil factor 1 increases expression
multiple interactions		 ISO 27-hydroxycholesterol results in increased expression of TFF1 mRNA
27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of TFF1 mRNA]		 CTD PMID:17872378 PMID:27856279 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol CTD PMID:15708352 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [27-hydroxycholesterol results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA] CTD PMID:24802026 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO 27-hydroxycholesterol results in increased expression of VCAM1 mRNA CTD PMID:19426978 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
multiple interactions
increases expression		 ISO 27-hydroxycholesterol results in increased secretion of VEGFA protein
Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased expression of VEGFA mRNA]; STAT3 protein promotes the reaction [27-hydroxycholesterol results in increased secretion of VEGFA protein]		 CTD PMID:27856279 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
3beta-hydroxycholest-5-en-26-oic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases chemical synthesis
multiple interactions		 ISO CYP27A1 protein results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid
[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid		 CTD PMID:8078928 PMID:9215552 PMID:9660774 PMID:14622972 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein] CTD PMID:11089551 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO 3-hydroxy-5-cholestenoic acid affects the reaction [NR1H3 protein binds to NCOA2 protein]; 3-hydroxy-5-cholestenoic acid binds to and results in increased activity of NR1H3 protein CTD PMID:11089551 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases activity ISO 4,4-dimethylcholesta-8,14,24-trienol results in increased activity of NR1H3 protein CTD PMID:9603267 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
5,6alpha-epoxy-5alpha-cholestan-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor increases phosphorylation EXP cholesterol alpha-oxide results in increased phosphorylation of EGFR protein CTD PMID:20466046 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases metabolic processing
multiple interactions		 ISO EPHX1 protein results in increased metabolism of cholesterol alpha-oxide
disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]; Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]		 CTD PMID:2043152 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO cholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein] CTD PMID:20466046 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20466046 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP2 mRNA CTD PMID:20466046 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP9 mRNA CTD PMID:20466046 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 EXP cholesterol alpha-oxide results in increased phosphorylation of MTOR protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]		 CTD PMID:20466046 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
5alpha-cholest-7-en-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Msmo1 methylsterol monooxygenase 1 increases abundance ISO MSMO1 protein results in increased abundance of lathosterol CTD PMID:23125191 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973 		JBrowse link
7-ketocholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 decreases expression
multiple interactions		 ISO 7-ketocholesterol results in decreased expression of ABCD1 mRNA
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD1 mRNA]; argan oil inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD1 mRNA]		 CTD PMID:29065513 NCBI chr  X:157,073,860...157,095,652
Ensembl chr  X:157,072,736...157,095,274 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression
multiple interactions		 ISO 7-ketocholesterol results in decreased expression of ABCD3 mRNA
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD3 mRNA]; argan oil inhibits the reaction [7-ketocholesterol results in decreased expression of ABCD3 mRNA]		 CTD PMID:29065513 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions
decreases expression		 ISO [7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [7-ketocholesterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA; [7-ketocholesterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA
7-ketocholesterol results in decreased expression of ABCG5 mRNA		 CTD PMID:23454145 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO [7-ketocholesterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA; [7-ketocholesterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA CTD PMID:23454145 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO [7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [7-ketocholesterol co-treated with Rotenone] results in decreased expression of ACAT1 mRNA CTD PMID:23454145 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884 		JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO 7-ketocholesterol results in decreased expression of ACOX1 mRNA CTD PMID:29065513 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding		 ISO
EXP		 7-ketocholesterol inhibits the reaction [AHR protein binds to CYP1A1 enhancer]; 7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; 7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]
7-ketocholesterol binds to AHR protein		 CTD PMID:11042205 PMID:16480812 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 7-ketocholesterol results in decreased phosphorylation of and results in decreased activity of AKT1 protein; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased phosphorylation of and results in decreased activity of AKT1 protein] CTD PMID:19351882 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP 7-ketocholesterol results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of BAX protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased expression of BAX protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased expression of BAX protein]		 CTD PMID:25845326 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [7-ketocholesterol results in decreased expression of BCL2 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in decreased expression of BCL2 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in decreased expression of BCL2 protein] CTD PMID:25845326 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l11 BCL2 like 11 affects localization ISO 7-ketocholesterol affects the localization of BCL2L11 protein CTD PMID:15955068 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
multiple interactions		 EXP 7-ketocholesterol results in decreased expression of BID protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in decreased expression of BID protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in decreased expression of BID protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in decreased expression of BID protein]		 CTD PMID:25845326 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Casp1 caspase 1 multiple interactions
affects localization
increases activity		 ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; methyl-beta-cyclodextrin inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; SMPD1 protein affects the reaction [7-ketocholesterol affects the localization of CASP1 protein]; SMPD1 protein affects the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; tempol inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Verapamil inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions		 ISO
EXP		 7-ketocholesterol results in increased activity of CASP3 protein
7-ketocholesterol results in increased cleavage of CASP3 protein
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein]; argan oil inhibits the reaction [7-ketocholesterol results in increased cleavage of CASP3 protein]
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; beta-Tocopherol affects the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]; Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein]		 CTD PMID:12450566 PMID:16934673 PMID:24650663 PMID:25845326 PMID:29065513 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO 7-ketocholesterol results in increased activity of CASP7 protein
Serotonin inhibits the reaction [7-ketocholesterol results in increased activity of CASP7 protein]		 CTD PMID:24650663 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP8 protein] CTD PMID:25845326 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [7-ketocholesterol results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased activity of CASP9 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased activity of CASP9 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased activity of CASP9 protein] CTD PMID:25845326 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of CCL2 protein
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL2 protein]		 CTD PMID:24895526 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL3 protein] CTD PMID:24895526 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of CCL4 protein
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL4 protein]		 CTD PMID:24895526 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL5 protein] CTD PMID:24895526 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO CD38 gene mutant form promotes the reaction [7-ketocholesterol results in increased expression of MAP1LC3B protein] CTD PMID:24445604 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672 		JBrowse link
G Csf2 colony stimulating factor 2 increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of CSF2 protein
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CSF2 protein]		 CTD PMID:24895526 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Csf3 colony stimulating factor 3 increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of CSF3 protein
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CSF3 protein]		 CTD PMID:24895526 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO 7-ketocholesterol results in increased expression of CXCL10 protein CTD PMID:24895526 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cybb cytochrome b-245 beta chain affects localization
multiple interactions		 ISO 7-ketocholesterol affects the localization of CYBB protein
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein]		 CTD PMID:28633109 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO
EXP		 7-ketocholesterol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 protein]; 7-ketocholesterol inhibits the reaction [AHR protein binds to CYP1A1 enhancer]; 7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; 7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
7-ketocholesterol inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 protein]; 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 mRNA]; 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; 7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
7-ketocholesterol results in decreased expression of CYP1A1 protein		 CTD PMID:11042205 PMID:18708364 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases metabolic processing ISO CYP27A1 protein results in increased metabolism of 7-ketocholesterol CTD PMID:10869358 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP 7-ketocholesterol results in decreased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation EXP 7-ketocholesterol results in increased phosphorylation of EGFR protein CTD PMID:20466046 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity
increases expression
multiple interactions		 ISO 7-ketocholesterol results in decreased activity of HMGCR protein
7-ketocholesterol results in increased expression of HMGCR mRNA
[7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of HMGCR mRNA; [7-ketocholesterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA; [7-ketocholesterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA		 CTD PMID:7751816 PMID:23454145 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO 7-ketocholesterol results in decreased expression of HSD17B4 mRNA CTD PMID:29065513 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 7-ketocholesterol results in increased expression of ICAM1 mRNA; 7-ketocholesterol results in increased expression of ICAM1 protein CTD PMID:15720832 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
increases expression		 ISO 7-ketocholesterol results in decreased expression of IL10 mRNA
resveratrol promotes the reaction [7-ketocholesterol results in increased expression of IL10 protein]		 CTD PMID:24727230 PMID:24895526 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of IL1B protein
Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; SMPD1 protein affects the reaction [7-ketocholesterol results in increased expression of IL1B protein]		 CTD PMID:28633109 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO [resveratrol co-treated with 7-ketocholesterol] results in increased expression of IL1RN protein CTD PMID:24895526 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of IL6 protein
7-ketocholesterol results in decreased degradation of and results in increased expression of IL6 mRNA; pyrazolanthrone inhibits the reaction [7-ketocholesterol results in increased expression of IL6 mRNA]; resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of IL6 protein]; SB 203580 inhibits the reaction [7-ketocholesterol results in increased expression of IL6 mRNA]		 CTD PMID:18515973 PMID:24895526 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of HMGCR mRNA CTD PMID:23454145 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of MAP1LC3B protein
CD38 gene mutant form promotes the reaction [7-ketocholesterol results in increased expression of MAP1LC3B protein]		 CTD PMID:24445604 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 U 0126 inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK1 protein]
RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15955068 PMID:20466046 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO
EXP		 7-ketocholesterol results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK3 protein]
U 0126 inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15955068 PMID:20466046 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions		 EXP
ISO		 7-ketocholesterol results in increased expression of MMP2 mRNA
7-ketocholesterol results in increased expression of MMP2 protein
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of MMP2 protein]		 CTD PMID:20466046 PMID:24895526 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 EXP
ISO		 7-ketocholesterol results in increased expression of MMP9 mRNA
7-ketocholesterol results in increased expression of MMP9 protein
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of MMP9 protein]		 CTD PMID:20466046 PMID:24895526 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 EXP 7-ketocholesterol results in increased phosphorylation of MTOR protein
RTKI cpd inhibits the reaction [7-ketocholesterol results in increased phosphorylation of MTOR protein]		 CTD PMID:20466046 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 ISO
EXP		 7-ketocholesterol results in increased expression of NFKB1 protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of NFKB1 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased expression of NFKB1 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased expression of NFKB1 protein]
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of NFKB1 protein]		 CTD PMID:24895526 PMID:25845326 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
multiple interactions		 EXP 7-ketocholesterol results in increased phosphorylation of NFKBIA protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of NFKBIA protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased phosphorylation of NFKBIA protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased expression of NFKBIA protein]		 CTD PMID:25845326 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
affects localization		 ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein] CTD PMID:28633109 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO 7-ketocholesterol results in increased expression of NOS2 mRNA CTD PMID:12085989 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 decreases expression ISO 7-ketocholesterol results in decreased expression of NPC1L1 CTD PMID:23454145 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 EXP 7-ketocholesterol results in increased cleavage of PARP1 protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased cleavage of PARP1 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased cleavage of PARP1 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased cleavage of PARP1 protein]		 CTD PMID:25845326 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO 7-ketocholesterol inhibits the reaction [Methylcholanthrene results in increased expression of PON1 mRNA]; 7-ketocholesterol inhibits the reaction [Quercetin results in increased expression of PON1 mRNA]; 7-ketocholesterol inhibits the reaction [resveratrol results in increased expression of PON1 mRNA] CTD PMID:15169886 PMID:15458977 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Pon2 paraoxonase 2 increases activity
increases expression		 ISO 7-ketocholesterol results in increased activity of PON2 protein
7-ketocholesterol results in increased expression of PON2 mRNA		 CTD PMID:12615656 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119 		JBrowse link
G Pon3 paraoxonase 3 multiple interactions ISO 7-ketocholesterol inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin] CTD PMID:12615656 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions		 ISO 7-ketocholesterol results in decreased expression of PPARA mRNA
alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA]; argan oil inhibits the reaction [7-ketocholesterol results in decreased expression of PPARA mRNA]		 CTD PMID:29065513 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO 7-ketocholesterol results in increased phosphorylation of and results in increased activity of PTK2B protein CTD PMID:15955068 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656 		JBrowse link
G Pycard PYD and CARD domain containing affects localization
multiple interactions		 ISO 7-ketocholesterol affects the localization of PYCARD protein
Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; SMPD1 protein affects the reaction [7-ketocholesterol affects the localization of PYCARD protein]		 CTD PMID:28633109 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions		 ISO
EXP		 7-ketocholesterol results in increased expression of RELA protein
7-ketocholesterol results in increased expression of and results in increased phosphorylation of RELA protein; Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of and results in increased phosphorylation of RELA protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased expression of and results in increased phosphorylation of RELA protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased expression of and results in increased phosphorylation of RELA protein]
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of RELA protein]		 CTD PMID:24895526 PMID:25845326 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO SMPD1 protein affects the reaction [7-ketocholesterol affects the localization of CASP1 protein]; SMPD1 protein affects the reaction [7-ketocholesterol affects the localization of PYCARD protein]; SMPD1 protein affects the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; SMPD1 protein affects the reaction [7-ketocholesterol results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO 7-ketocholesterol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TGM2 mRNA] CTD PMID:16480812 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of TNF protein] CTD PMID:24895526 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 EXP 7-ketocholesterol results in increased expression of TP53 protein
Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of TP53 protein]; BAY 11-7085 inhibits the reaction [7-ketocholesterol results in increased expression of TP53 protein]; quercetin 3-O-beta-(2''-galloyl)-rhamnopyranoside inhibits the reaction [7-ketocholesterol results in increased expression of TP53 protein]		 CTD PMID:25845326 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO 7-ketocholesterol results in increased expression of VCAM1 mRNA; 7-ketocholesterol results in increased expression of VCAM1 protein CTD PMID:15720832 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 ISO 7-ketocholesterol results in increased expression of VEGFA protein
resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of VEGFA protein]		 CTD PMID:24895526 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
7alpha-hydroxycholest-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of 7 alpha-hydroxy-4-cholesten-3-one; AKR1D1 gene mutant form inhibits the reaction [AKR1D1 protein results in increased metabolism of 7 alpha-hydroxy-4-cholesten-3-one] CTD PMID:21185810 PMID:25500266 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941 		JBrowse link
7alpha-hydroxycholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 decreases activity EXP cholest-5-en-3 beta,7 alpha-diol results in decreased activity of ADAM17 protein CTD PMID:15591071 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280 		JBrowse link
G App amyloid beta precursor protein increases chemical synthesis
decreases secretion		 EXP APP protein results in increased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol
cholest-5-en-3 beta,7 alpha-diol results in decreased secretion of APP protein		 CTD PMID:15591071 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO alpha-Tocopherol inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein]; beta-Tocopherol affects the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein] CTD PMID:12450566 PMID:16934673 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CCL2 mRNA]; Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of CCL2 mRNA] CTD PMID:24802026 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion
increases expression		 ISO cholest-5-en-3 beta,7 alpha-diol results in increased secretion of CCL3 protein
cholest-5-en-3 beta,7 alpha-diol results in increased expression of CCL3 mRNA		 CTD PMID:24370436 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
increases secretion		 ISO cholest-5-en-3 beta,7 alpha-diol results in increased expression of CCL4 mRNA
cholest-5-en-3 beta,7 alpha-diol results in increased secretion of CCL4 protein		 CTD PMID:24370436 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO cholest-5-en-3 beta,7 alpha-diol results in increased expression of CD36 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]; Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of CD36 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of CD36 mRNA]		 CTD PMID:24802026 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of cholest-5-en-3 beta,7 alpha-diol CTD PMID:14640697 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions EXP [Uranyl Nitrate results in decreased activity of CYP7A1 protein] which results in decreased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol CTD PMID:20362056 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity EXP cholest-5-en-3 beta,7 alpha-diol results in decreased activity of HMGCR protein CTD PMID:9199277 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [cholest-5-en-3 beta,7 alpha-diol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241 		JBrowse link
G Itgb1 integrin subunit beta 1 increases expression
multiple interactions		 ISO cholest-5-en-3 beta,7 alpha-diol results in increased expression of ITGB1 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]; Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of ITGB1 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of ITGB1 mRNA]		 CTD PMID:24802026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Lpl lipoprotein lipase decreases activity
decreases expression		 ISO cholest-5-en-3 beta,7 alpha-diol results in decreased activity of LPL protein
cholest-5-en-3 beta,7 alpha-diol results in decreased expression of LPL mRNA		 CTD PMID:8567968 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity ISO cholest-5-en-3 beta,7 alpha-diol results in increased activity of MAPK1 protein CTD PMID:11058697 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity ISO cholest-5-en-3 beta,7 alpha-diol results in increased activity of MAPK3 protein CTD PMID:11058697 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of MMP9 mRNA] CTD PMID:24802026 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions		 ISO cholest-5-en-3 beta,7 alpha-diol results in increased expression of PTGES mRNA
Quercetin analog inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased expression of PTGES mRNA]		 CTD PMID:24802026 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO [24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 protein
cholest-5-en-3 beta,7 alpha-diol results in increased expression of PTGS2 protein		 CTD PMID:24802026 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions		 ISO cholest-5-en-3 beta,7 alpha-diol results in increased expression of TLR4 mRNA
[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA; Quercetin analog inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]; Quercetin inhibits the reaction [[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of TLR4 mRNA]		 CTD PMID:24802026 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
cholest-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 multiple interactions ISO [AKR1D1 protein co-treated with NADP] results in increased reduction of cholest-4-en-3-one CTD PMID:25500266 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941 		JBrowse link
cholesta-5,7-dien-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP 7-dehydrocholesterol results in decreased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases abundance
multiple interactions
increases reduction		 ISO DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol
[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterol
DHCR7 results in increased reduction of 7-dehydrocholesterol
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]		 CTD PMID:15896653 PMID:16365879 PMID:16446309 PMID:16824767 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904 		JBrowse link
cholesterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases export
affects expression
multiple interactions
affects export
increases transport		 ISO
EXP		 ABCA1 protein results in increased export of Cholesterol
cholesterol cotreated with 25-hydroxycholesterol decreases expression of abca1 mrna and protein in rat hepatoma cells; and increases expression of abca1 mRNA in rat fibroblasts
1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]]; 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; [HCAR2 protein results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol; [Resveratrol results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol; APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]; APOA1 protein promotes the reaction [ABCA1 protein results in increased export of Cholesterol]; Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]; Glyoxal inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]; Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]; Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]; triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]]
[[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterol; [Cholesterol co-treated with 25-hydroxycholesterol] results in decreased expression of ABCA1 mRNA; Cholesterol inhibits the reaction [bisphenol A results in decreased expression of ABCA1 mRNA]
ABCA1 protein affects the export of Cholesterol
[[Niacin binds to and results in increased activity of HCAR2 protein] which results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol; [[Plant Preparations co-treated with Cholesterol, Dietary] results in increased expression of ABCA1 mRNA] which results in increased secretion of Cholesterol; [Capsaicin results in increased expression of ABCA1 protein] which results in decreased uptake of Cholesterol; [Capsaicin results in increased expression of ABCA1 protein] which results in increased secretion of Cholesterol; [Cholesterol co-treated with Dietary Fats] results in increased expression of ABCA1 mRNA; [Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCA1 mRNA		 CTD PMID:14993927 PMID:15694933 PMID:15983222 PMID:16118212 PMID:17526932 PMID:18356535 PMID:20372816 PMID:20655299 PMID:21908651 PMID:22022523 PMID:23900008 PMID:28859904, PMID:17526932 RGD:2308820 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 increases secretion ISO ABCB11 protein results in increased secretion of Cholesterol CTD PMID:14570929 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects export ISO ABCB4 protein affects the export of Cholesterol CTD PMID:15019087 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO [Niacin results in increased expression of ABCG1 protein] which results in increased export of Cholesterol; HCAR2 protein inhibits the reaction [[Niacin results in increased expression of ABCG1 protein] which results in increased export of Cholesterol]
[resveratrol results in increased expression of ABCG1 protein] which results in increased secretion of Cholesterol		 CTD PMID:20372816 PMID:21317532 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases activity
multiple interactions		 ISO Cholesterol results in increased activity of ABCG2 protein
Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]		 CTD PMID:27475308 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects export
multiple interactions
increases expression
decreases expression
increases secretion		 ISO
EXP		 ABCG5 protein affects the export of Cholesterol
[Diosgenin results in increased expression of ABCG5 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol results in decreased expression of ABCG5 mRNA] which results in decreased secretion of Cholesterol
Cholesterol results in increased expression of ABCG5 mRNA
Cholesterol results in decreased expression of ABCG5 mRNA
[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCG5 mRNA; Cholates promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]; Diosgenin promotes the reaction [ABCG5 protein results in increased secretion of Cholesterol]		 CTD PMID:12963437 PMID:15611112 PMID:15683829 PMID:15696852 PMID:18356535 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases secretion
multiple interactions
increases expression
decreases expression
affects export		 ISO
EXP		 ABCG8 protein results in increased secretion of Cholesterol
[Diosgenin results in increased expression of ABCG8 mRNA] which results in increased secretion of Cholesterol; [Ethinyl Estradiol results in decreased expression of ABCG8 mRNA] which results in decreased secretion of Cholesterol
Cholesterol results in increased expression of ABCG8 mRNA
Cholesterol results in decreased expression of ABCG8 mRNA
[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of ABCG8 mRNA; Cholates promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]; Diosgenin promotes the reaction [ABCG8 protein results in increased secretion of Cholesterol]
ABCG8 protein affects the export of Cholesterol		 CTD PMID:12963437 PMID:15611112 PMID:15683829 PMID:15696852 PMID:18356535 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACACA mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACACA mRNA CTD PMID:24440342 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACADM mRNA] CTD PMID:24440342 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO [Copper co-treated with Cholesterol] results in increased activity of ACHE protein; Clioquinol inhibits the reaction [[Copper co-treated with Cholesterol] results in increased activity of ACHE protein] CTD PMID:25856695 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acly ATP citrate lyase multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of ACLY mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of ACLY mRNA CTD PMID:24440342 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of ACOX1 mRNA] CTD PMID:24440342 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050 		JBrowse link
G Ager advanced glycosylation end product-specific receptor affects abundance ISO AGER protein affects the abundance of Cholesterol CTD PMID:20372816 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Agt angiotensinogen multiple interactions
affects abundance
increases expression		 ISO
EXP		 Cholesterol inhibits the reaction [irbesartan results in increased expression of AGT protein]
[Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGT mRNA; Hydralazine inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]
Cholesterol results in increased expression of AGT protein		 CTD PMID:12495295 PMID:19028402 PMID:19109942 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions		 ISO Cholesterol results in increased expression of AGTR1 mRNA
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]		 CTD PMID:19028402 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions EXP [Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 mRNA; [Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 protein; [Puromycin Aminonucleoside co-treated with Cholesterol] results in increased expression of AGTR2 mRNA; Rosiglitazone promotes the reaction [[Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 mRNA]; Rosiglitazone promotes the reaction [[Cholesterol co-treated with Methylthiouracil] results in increased expression of AGTR2 protein] CTD PMID:12495295 PMID:21269478 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [beta-Naphthoflavone results in increased activity of AHR protein] which results in decreased chemical synthesis of and results in decreased secretion of Cholesterol CTD PMID:22234961 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP		 Cholesterol inhibits the reaction [irbesartan results in increased expression of AKT1 protein]
[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]
Cholesterol results in increased expression of and results in increased phosphorylation of AKT1 protein		 CTD PMID:19028402 PMID:19672739 PMID:31877369 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alb albumin multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of ALB protein; [lard co-treated with Cholesterol] results in increased expression of ALB protein CTD PMID:26606054 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Anxa2 annexin A2 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of ANXA2 mRNA CTD PMID:22129739 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions
increases expression		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA] CTD PMID:19477266 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases export
affects transport
decreases expression
increases secretion		 ISO
EXP		 1-oleoyl-2-acetylglycerol inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [Acrolein affects the metabolism of APOA1 protein] which results in decreased secretion of Cholesterol; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [pirinixic acid binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Acrolein inhibits the reaction [APOA1 protein affects the transport of Cholesterol]; APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]; APOA1 protein promotes the reaction [ABCA1 protein results in increased export of Cholesterol]; Arachidonic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; CYP27A1 protein promotes the reaction [APOA1 protein results in increased secretion of Cholesterol]; Fingolimod Hydrochloride promotes the reaction [APOA1 protein results in increased secretion of Cholesterol]; Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; mastoparan inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]; Oleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; palmitoleic acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]]; PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]]; resveratrol inhibits the reaction [APOA1 protein results in increased export of Cholesterol]
[Ethanol co-treated with APOA1 protein] results in decreased abundance of Cholesterol
APOA1 affects the transport of Cholesterol
Cholesterol results in decreased expression of APOA1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Niacin promotes the reaction [APOA1 protein results in increased export of Cholesterol]]; 27-hydroxycholesterol promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; 27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; [Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol; [Glutathione co-treated with Quercetin] promotes the reaction [APOA1 protein results in increased export of Cholesterol]; [TO-901317 co-treated with APOA1 protein] results in increased secretion of Cholesterol; Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]; Niacin promotes the reaction [APOA1 protein results in increased export of Cholesterol]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]]; PPARG protein promotes the reaction [Niacin promotes the reaction [APOA1 protein results in increased export of Cholesterol]]; Probucol inhibits the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; Quercetin promotes the reaction [APOA1 protein results in increased export of Cholesterol]; STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]; TO-901317 promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]		 CTD PMID:12531903 PMID:12595494 PMID:15983222 PMID:16037261 PMID:16115471 PMID:16118212 PMID:16126721 PMID:17478430 PMID:19797938 PMID:20056921 PMID:20083572 PMID:21088444 PMID:23041272 PMID:25204422 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apob apolipoprotein B increases expression
multiple interactions		 EXP Cholesterol results in increased expression of APOB protein
Selenium inhibits the reaction [Cholesterol results in increased expression of APOB protein]		 CTD PMID:16271152 PMID:16581047 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Apoe apolipoprotein E affects response to substance
affects localization
multiple interactions
increases abundance
increases export		 ISO
EXP		 APOE protein affects the susceptibility to Cholesterol
Cholesterol affects the localization of APOE protein
Cholesterol promotes the reaction [APOE protein binds to CAV1 protein]
APOE gene mutant form results in increased abundance of Cholesterol
APOE protein results in increased export of Cholesterol
24-diamino-5-phenylthiazole inhibits the reaction [TO-901317 promotes the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]]; [APOE affects the susceptibility to Dietary Fats] which affects the abundance of Cholesterol; APOE gene mutant form promotes the reaction [Dietary Fats results in increased abundance of Cholesterol]; APOE inhibits the reaction [Cholesterol, Dietary results in increased abundance of Cholesterol]; Capsaicin inhibits the reaction [[APOE affects the susceptibility to Dietary Fats] which affects the abundance of Cholesterol]; CAV1 protein affects the reaction [Cholesterol affects the localization of APOE protein]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol affects the localization of APOE protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; paricalcitol inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; TO-901317 promotes the reaction [[APOE gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]		 CTD PMID:11397713 PMID:12472773 PMID:16179587 PMID:21169230 PMID:21908651 PMID:22022523 PMID:24933211 PMID:25037058 PMID:32853627 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases oxidation		 ISO
EXP		 [Copper co-treated with Cholesterol] results in increased expression of APP mRNA
APP protein results in increased oxidation of Cholesterol		 CTD PMID:15591071 PMID:17134702 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Aqp9 aquaporin 9 increases expression ISO Cholesterol results in increased expression of AQP9 mRNA CTD PMID:26296894 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781 		JBrowse link
G Areg amphiregulin increases expression
multiple interactions		 ISO Cholesterol results in increased expression of AREG mRNA
CLEC4E protein promotes the reaction [Cholesterol results in increased expression of AREG mRNA]		 CTD PMID:26296894 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179 		JBrowse link
G Atp7b ATPase copper transporting beta increases abundance EXP ATP7B gene mutant form results in increased abundance of Cholesterol CTD PMID:17303181 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 Cholesterol analog results in decreased expression of BAX mRNA
Cholesterol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]		 CTD PMID:19477266 PMID:29486218 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 Cholesterol analog results in decreased expression of BCL2 mRNA
Cholesterol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]		 CTD PMID:19477266 PMID:29486218 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression EXP Cholesterol analog results in increased expression of BCL2A1 mRNA CTD PMID:19477266 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Dietary Fats co-treated with Cholesterol] results in decreased expression of BDNF protein; Selenium inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of BDNF protein] CTD PMID:30695686 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Bik BCL2-interacting killer increases expression EXP Cholesterol analog results in increased expression of BIK mRNA CTD PMID:19477266 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions
increases activity
affects localization		 EXP
ISO		 Cholesterol analog results in increased expression of CASP1 mRNA
Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]; SMPD1 protein affects the reaction [Cholesterol analog affects the localization of CASP1 protein]; SMPD1 protein affects the reaction [Cholesterol analog results in increased activity of CASP1 protein]; tempol inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]; Verapamil inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein]
[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein]		 CTD PMID:19477266 PMID:25833014 PMID:28633109 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression		 ISO
EXP		 [Copper co-treated with Cholesterol] results in increased activity of CASP3 protein; Cholesterol inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein modified form]; methyl-beta-cyclodextrin inhibits the reaction [Cholesterol results in increased activity of CASP3 protein]
Cholesterol results in increased cleavage of CASP3 protein
Cholesterol analog results in increased expression of CASP3 mRNA
Cholesterol analog results in increased cleavage of CASP3 protein
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP3 mRNA]		 CTD PMID:17134702 PMID:19477266 PMID:21872649 PMID:28275691 PMID:29486218 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp4 caspase 4 multiple interactions
increases expression		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CASP4 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP4 mRNA] CTD PMID:19477266 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
increases activity		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP8 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP8 mRNA]; Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]; Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of CASP8 protein]
Cholesterol analog results in increased expression of CASP8 mRNA; Cholesterol results in increased expression of CASP8 protein		 CTD PMID:19477266 PMID:20946910 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
increases activity		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased activity of CASP9 protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased activity of CASP9 protein]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CASP9 mRNA] CTD PMID:19477266 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions
increases expression		 EXP
ISO		 [Cholesterol co-treated with Cholic Acid] results in decreased activity of CAT protein; lupeol inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased activity of CAT protein]; lupeol linoleate inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased activity of CAT protein]
Cholesterol results in increased expression of CAT protein		 CTD PMID:16933029 PMID:29486218 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 increases transport
multiple interactions		 ISO
EXP		 CAV1 protein results in increased transport of Cholesterol
CAV1 protein affects the reaction [Cholesterol affects the localization of APOE protein]
Cholesterol promotes the reaction [APOE protein binds to CAV1 protein]		 CTD PMID:12640124 PMID:21169230 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Cav3 caveolin 3 affects import ISO CAV3 protein affects the import of Cholesterol CTD PMID:19221014 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917 		JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Cholesterol results in increased expression of CCL1 mRNA CTD PMID:26296894 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO
EXP		 [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CCL2 mRNA; Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 protein]
[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein; [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of CCL2 mRNA; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein]
Cholesterol results in increased expression of CCL2 mRNA; Cholesterol results in increased expression of CCL2 protein		 CTD PMID:19028402 PMID:22129739 PMID:25833014 PMID:26606054 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions
increases expression		 ISO CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CCL4 mRNA] CTD PMID:26296894 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CCL7 mRNA CTD PMID:22129739 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA; Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]; rosiglitazone inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA] CTD PMID:18302760 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cd40lg CD40 ligand multiple interactions
increases expression		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of CD40LG mRNA] CTD PMID:19477266 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562 		JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CDK5R2 mRNA CTD PMID:22129739 NCBI chr 9:82,120,059...82,121,527
Ensembl chr 9:82,120,059...82,121,527 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CDKN1A mRNA CTD PMID:22129739 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol CTD PMID:23063590 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Ces1d carboxylesterase 1D increases metabolic processing
increases abundance
increases expression		 ISO
EXP		 CES1 protein results in increased metabolism of Cholesterol
CES1 protein results in increased abundance of Cholesterol
Cholesterol results in increased expression of CES1 mRNA		 CTD PMID:8049197 PMID:11015575 PMID:12773168 PMID:15825828 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Clec4e C-type lectin domain family 4, member E multiple interactions
increases response to substance		 ISO [Cholesterol co-treated with CLEC4E] results in increased expression of CXCL2 protein; [Cholesterol co-treated with CLEC4E] results in increased expression of TNF protein; Cholesterol binds to and results in increased activity of CLEC4E protein; CLEC4E protein inhibits the reaction [Cholesterol results in increased expression of TIMP3 mRNA]; CLEC4E protein promotes the reaction [[Cholesterol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; CLEC4E protein promotes the reaction [Cholesterol results in increased expression of AREG mRNA]; CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CCL4 mRNA]; CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CLEC5A mRNA]; CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CSF1 mRNA]; CLEC4E protein promotes the reaction [Cholesterol results in increased expression of DCSTAMP mRNA]
CLEC4E protein results in increased susceptibility to Cholesterol		 CTD PMID:26296894 NCBI chr 4:156,271,087...156,276,243
Ensembl chr 4:156,270,920...156,276,304 		JBrowse link
G Clec5a C-type lectin domain containing 5A increases expression
multiple interactions		 ISO Cholesterol results in increased expression of CLEC5A mRNA
CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CLEC5A mRNA]		 CTD PMID:26296894 NCBI chr 4:68,810,330...68,819,921
Ensembl chr 4:68,808,359...68,819,928 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CPT1A mRNA] CTD PMID:24440342 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Dietary Fats co-treated with Cholesterol] results in decreased expression of CREB1 protein; Selenium inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of CREB1 protein] CTD PMID:30695686 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crybb3 crystallin, beta B3 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CRYBB3 mRNA CTD PMID:22129739 NCBI chr12:49,564,991...49,571,008
Ensembl chr12:49,565,992...49,571,006 		JBrowse link
G Cs citrate synthase multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of CS mRNA CTD PMID:24440342 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963 		JBrowse link
G Csf1 colony stimulating factor 1 increases expression
multiple interactions		 ISO Cholesterol results in increased expression of CSF1 mRNA
CLEC4E protein promotes the reaction [Cholesterol results in increased expression of CSF1 mRNA]		 CTD PMID:26296894 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560 		JBrowse link
G Cst3 cystatin C multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of CST3 protein CTD PMID:26606054 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615 		JBrowse link
G Ctsb cathepsin B decreases activity ISO Cholesterol results in decreased activity of CTSB protein CTD PMID:28275691 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Cholesterol co-treated with CLEC4E] results in increased expression of CXCL2 protein CTD PMID:26296894 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CXCL9 mRNA CTD PMID:22129739 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
affects localization		 EXP
ISO		 [Cholesterol co-treated with Particulate Matter] results in increased expression of CYBB protein; [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of NOX2 mRNA; alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of CYBB protein]
Cholesterol analog affects the localization of CYBB protein		 CTD PMID:26606054 PMID:28633109 PMID:30672636 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 affects metabolic processing
increases metabolic processing		 ISO CYP11A1 protein affects the metabolism of Cholesterol
CYP11A1 protein results in increased metabolism of Cholesterol		 CTD PMID:16054388 PMID:19900470 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects chemical synthesis ISO CYP17A1 protein affects the chemical synthesis of Cholesterol CTD PMID:15761033 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Cholesterol results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases chemical synthesis
multiple interactions
increases secretion		 ISO
EXP		 CYP27A1 protein results in decreased chemical synthesis of Cholesterol
[[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 25-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; CYP27A1 protein promotes the reaction [APOA1 protein results in increased secretion of Cholesterol]; CYP27A1 protein results in increased hydroxylation of and results in decreased abundance of Cholesterol
[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of CYP27A1 mRNA
CYP27A1 protein results in increased secretion of Cholesterol		 CTD PMID:8078928 PMID:8496670 PMID:9215552 PMID:9660774 PMID:11408283 PMID:11714861 PMID:12117727 PMID:12531903 PMID:16477808 PMID:18356535 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity ISO Cholesterol results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Cholesterol results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 multiple interactions
increases hydroxylation		 ISO CYP46A1 gene SNP affects the metabolism of and affects the abundance of Cholesterol
CYP46A1 protein results in increased hydroxylation of Cholesterol		 CTD PMID:14640697 PMID:19286353 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 affects metabolic processing
multiple interactions
increases metabolic processing
increases expression		 ISO
EXP		 CYP7A1 protein affects the metabolism of Cholesterol
CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of EIF4EBP1 protein]; CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of GSK3B protein]; CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6 protein]; CYP7A1 mRNA inhibits the reaction [Tretinoin results in increased abundance of Cholesterol]
CYP7A1 protein results in increased metabolism of Cholesterol
Cholesterol results in increased expression of CYP7A1 mRNA
turmeric extract promotes the reaction [Cholesterol results in increased expression of CYP7A1 mRNA]		 CTD PMID:1175606 PMID:7925343 PMID:11013305 PMID:15696852 PMID:21535835 PMID:28275691 PMID:30709899 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 increases activity
increases expression		 EXP Cholesterol results in increased activity of CYP7B1 protein
Cholesterol results in increased expression of CYP7B1 mRNA		 CTD PMID:12029625 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP cholesterol decreases expression of Cyp8b1 mRNA in liver RGD PMID:25263431 RGD:15045610 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388 		JBrowse link
G Dapk1 death associated protein kinase 1 multiple interactions
increases expression		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of DAPK1 mRNA] CTD PMID:19477266 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778 		JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions
increases expression		 ISO CLEC4E protein promotes the reaction [Cholesterol results in increased expression of DCSTAMP mRNA] CTD PMID:26296894 NCBI chr 7:78,725,173...78,756,160
Ensembl chr 7:78,649,875...78,650,906
Ensembl chr 7:78,649,875...78,650,906 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of DGAT1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of DGAT1 mRNA CTD PMID:24440342 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of DGAT2 mRNA] CTD PMID:24440342 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects abundance
multiple interactions		 ISO DHCR24 protein affects the abundance of Cholesterol
[DHCR24 protein results in increased metabolism of Desmosterol] which results in increased abundance of Cholesterol		 CTD PMID:19260826 PMID:23042211 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases abundance
multiple interactions
increases chemical synthesis
affects response to substance		 ISO DHCR7 mutant form results in decreased abundance of Cholesterol
Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]
DHCR7 mutant form affects the susceptibility to Cholesterol		 CTD PMID:15896653 PMID:16446309 PMID:19365639 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904 		JBrowse link
G Dio1 iodothyronine deiodinase 1 affects expression
decreases expression
decreases activity		 EXP Cholesterol affects the expression of DIO1 mRNA
Cholesterol results in decreased expression of DIO1 mRNA
Cholesterol results in decreased activity of DIO1 protein		 CTD PMID:16271152 PMID:16874406 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases degradation ISO Cholesterol results in increased degradation of DIO2 protein CTD PMID:30545937 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of EGFR mRNA CTD PMID:22129739 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha decreases abundance ISO EIF2S1 protein modified form results in decreased abundance of Cholesterol CTD PMID:16330322 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of EIF4A1 mRNA CTD PMID:22129739 NCBI chr10:56,271,257...56,276,764
Ensembl chr10:56,271,257...56,276,764 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases phosphorylation
multiple interactions		 ISO Cholesterol results in increased phosphorylation of EIF4EBP1 protein
CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of EIF4EBP1 protein]		 CTD PMID:28275691 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Epb41 erythrocyte membrane protein band 4.1 multiple interactions EXP [Hydrogen Peroxide co-treated with Cholesterol] results in decreased expression of and affects the localization of EPB41 protein; [Hydrogen Peroxide co-treated with Cholesterol] results in increased degradation of EPB41 protein; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [[Hydrogen Peroxide co-treated with Cholesterol] results in decreased expression of and affects the localization of EPB41 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [[Hydrogen Peroxide co-treated with Cholesterol] results in increased degradation of EPB41 protein] CTD PMID:20946910 NCBI chr 5:150,081,727...150,243,186
Ensembl chr 5:150,084,611...150,167,077 		JBrowse link
G Esm1 endothelial cell-specific molecule 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of ESM1 mRNA CTD PMID:22129739 NCBI chr 2:45,104,392...45,113,130
Ensembl chr 2:45,104,305...45,113,131 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of FABP1 protein CTD PMID:26606054 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954 		JBrowse link
G Fadd Fas associated via death domain multiple interactions
increases expression		 EXP Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of FADD protein]; Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of FADD protein] CTD PMID:20946910 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO
EXP		 Cholesterol inhibits the reaction [FGF7 protein results in increased expression of FAS mRNA]
[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of FAS mRNA
Cholesterol analog results in increased expression of FAS mRNA
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of FAS mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of FAS mRNA]		 CTD PMID:16162944 PMID:19477266 PMID:22129739 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand increases expression EXP Cholesterol analog results in increased expression of FASLG protein CTD PMID:19477266 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases chemical synthesis ISO FDFT1 protein results in increased chemical synthesis of Cholesterol CTD PMID:17483544 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302 		JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol; Dasatinib inhibits the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol]; NR1H4 protein mutant form inhibits the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol]; SRC protein promotes the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol] CTD PMID:30996006 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693 		JBrowse link
G Fgf7 fibroblast growth factor 7 multiple interactions ISO
EXP		 Cholesterol inhibits the reaction [FGF7 protein results in increased expression of FAS mRNA]; Cholesterol inhibits the reaction [FGF7 protein results in increased expression of SCD mRNA]
[1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of FGF7 protein		 CTD PMID:16034455 PMID:16162944 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 affects metabolic processing
decreases metabolic processing		 ISO FGFR4 protein affects the metabolism of Cholesterol
FGFR4 protein results in decreased metabolism of Cholesterol		 CTD PMID:11956156 PMID:15750181 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO Cholesterol results in increased expression of FLT1 mRNA CTD PMID:26296894 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GADD45G mRNA CTD PMID:22129739 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243 		JBrowse link
G Gbp2 guanylate binding protein 2 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GBP2 mRNA CTD PMID:22129739 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784 		JBrowse link
G Gbp4 guanylate binding protein 4 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GBP4 mRNA CTD PMID:22129739 NCBI chr 2:248,249,232...248,263,104
Ensembl chr 2:248,249,468...248,263,168 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Cholesterol results in increased expression of GCLC protein CTD PMID:29486218 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gjb1 gap junction protein, beta 1 decreases abundance ISO GJB1 protein results in decreased abundance of Cholesterol CTD PMID:27859493 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977 		JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions ISO Cholesterol inhibits the reaction [Progesterone results in decreased expression of GNAI3 protein] CTD PMID:19221014 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749 		JBrowse link
G Gnas GNAS complex locus multiple interactions ISO Cholesterol inhibits the reaction [Progesterone results in increased expression of GNAS protein] CTD PMID:19221014 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483 		JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha increases expression ISO Cholesterol results in increased expression of GP1BA mRNA CTD PMID:26296894 NCBI chr10:57,260,680...57,263,546
Ensembl chr10:57,260,680...57,263,546 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of GPAM mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of GPAM mRNA CTD PMID:24440342 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of GPX2 mRNA CTD PMID:26606054 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions		 ISO
EXP		 Cholesterol results in increased phosphorylation of GSK3B protein
[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]
CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of GSK3B protein]		 CTD PMID:28275691 PMID:31877369 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gtf3c6 general transcription factor 3C subunit 6 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GTF3C6 mRNA CTD PMID:22129739 NCBI chr20:45,347,788...45,356,868
Ensembl chr20:45,347,271...45,356,358 		JBrowse link
G Gzma granzyme A multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GZMA mRNA CTD PMID:22129739 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458 		JBrowse link
G Gzmb granzyme B multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GZMB mRNA CTD PMID:22129739 NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316 		JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of HACL1 mRNA CTD PMID:22129739 NCBI chr16:7,720,047...7,758,119
Ensembl chr16:7,714,465...7,758,189 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of HAVCR1 mRNA CTD PMID:26606054 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Cholesterol results in increased expression of HBEGF mRNA CTD PMID:26296894 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403 		JBrowse link
G Hcar2 hydroxycarboxylic acid receptor 2 multiple interactions ISO [HCAR2 protein results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol
[[Niacin binds to and results in increased activity of HCAR2 protein] which results in decreased expression of ABCA1 protein] which results in decreased export of Cholesterol; HCAR2 protein inhibits the reaction [[Niacin results in increased expression of ABCG1 protein] which results in increased export of Cholesterol]		 CTD PMID:20655299 PMID:21317532 NCBI chr12:38,160,464...38,161,546
Ensembl chr12:38,160,464...38,161,546 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of HIF1A mRNA CTD PMID:26606054 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity
decreases expression
multiple interactions		 ISO
EXP		 Cholesterol results in decreased activity of HMGCR protein
cholesterol decreases expression of Hmgcr mRNA in liver
[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA; [Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein; [turmeric extract co-treated with Cholesterol] results in decreased expression of HMGCR mRNA; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HMGCR mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of HMGCR protein]; Selenium promotes the reaction [Cholesterol results in decreased expression of HMGCR mRNA]
[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein; [[artemisic acid results in decreased expression of CEBPA mRNA] which results in decreased expression of HMGCR mRNA] which results in decreased chemical synthesis of Cholesterol; [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [artemisic acid results in decreased expression of HMGCR protein] which results in decreased chemical synthesis of Cholesterol; [Clozapine results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; [Haloperidol results in increased activity of HMGCR protein] which results in increased abundance of Cholesterol; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein]		 CTD PMID:11408283 PMID:12477733 PMID:16027736 PMID:16581047 PMID:17516993 PMID:18024962 PMID:21535835 PMID:23063590 PMID:30273964, PMID:25263431 RGD:15045610 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression		 EXP [Cholesterol co-treated with Particulate Matter] results in increased expression of HMOX1 mRNA; [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of HMOX1 mRNA; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of HMOX1 mRNA]]; Particulate Matter promotes the reaction [Cholesterol results in increased expression of HMOX1 mRNA]; turmeric extract inhibits the reaction [Cholesterol results in decreased expression of HMOX1 mRNA] CTD PMID:21535835 PMID:26606054 PMID:30672636 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP [Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of HNF4A mRNA] CTD PMID:30273964 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein] CTD PMID:25833014 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifi44 interferon-induced protein 44 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IFI44 mRNA CTD PMID:22129739 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IFIT3 mRNA CTD PMID:22129739 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382 		JBrowse link
G Ifng interferon gamma multiple interactions EXP [Cholesterol co-treated with Particulate Matter] results in increased expression of IFNG protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of IFNG protein] CTD PMID:30672636 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of IGF1 protein CTD PMID:16034455 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IGFBP1 mRNA CTD PMID:22129739 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions EXP [1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of IGFBP3 protein CTD PMID:16034455 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Il18bp interleukin 18 binding protein multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IL18BP mRNA CTD PMID:22129739 NCBI chr 1:167,091,521...167,095,727
Ensembl chr 1:167,091,522...167,093,560 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 [Cholesterol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; CLEC4E protein promotes the reaction [[Cholesterol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
Cholesterol results in increased expression of IL1B protein
Cholesterol analog results in increased expression of IL1B protein
Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein]; Cholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Cholesterol promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; SMPD1 protein affects the reaction [Cholesterol analog results in increased expression of IL1B protein]
[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein; [Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA; [Cholesterol co-treated with Particulate Matter] results in increased expression of IL1B protein; [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of IL1B mRNA; alpha-Linolenic Acid inhibits the reaction [[Cholesterol co-treated with Particulate Matter] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein]; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA]
Cholesterol results in increased expression of IL1B mRNA		 CTD PMID:22869926 PMID:25833014 PMID:26296894 PMID:26606054 PMID:28633109 PMID:30672636 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO Cholesterol results in increased expression of IL1RN mRNA CTD PMID:26296894 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO
EXP		 Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 protein]
[Cholesterol co-treated with Particulate Matter] results in increased expression of IL6 mRNA; alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of IL6 protein]]; Cholesterol promotes the reaction [Particulate Matter results in increased expression of IL6 protein]
Cholesterol results in increased expression of IL6 mRNA; Cholesterol results in increased expression of IL6 protein		 CTD PMID:19028402 PMID:30672636 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Inhba inhibin subunit beta A increases expression ISO Cholesterol results in increased expression of INHBA mRNA CTD PMID:26296894 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Cholesterol analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of IRF7 mRNA CTD PMID:22129739 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456 		JBrowse link
G Irs1 insulin receptor substrate 1 affects abundance ISO IRS1 gene polymorphism affects the abundance of Cholesterol CTD PMID:10591678 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of ISG15 mRNA CTD PMID:22129739 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases localization EXP Cholesterol results in decreased localization of KCNH2 protein CTD PMID:21525004 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kitlg KIT ligand increases expression ISO Cholesterol results in increased expression of KITLG mRNA CTD PMID:26296894 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 increases expression ISO Cholesterol results in increased expression of LAMP1 protein CTD PMID:28275691 NCBI chr16:81,689,576...81,714,341
Ensembl chr16:81,689,335...81,714,419 		JBrowse link
G Lcat lecithin cholesterol acyltransferase increases acylation
multiple interactions		 ISO
EXP		 LCAT protein results in increased acylation of Cholesterol
[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LCAT protein]		 CTD PMID:4847537 PMID:30273964 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of LCN2 mRNA CTD PMID:22129739 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Ldlr low density lipoprotein receptor increases uptake
affects abundance
increases response to substance
multiple interactions
decreases expression
decreases activity		 ISO
EXP		 LDLR protein results in increased uptake of Cholesterol
LDLR protein affects the abundance of Cholesterol
LDLR gene mutant form results in increased susceptibility to Cholesterol
(+)-JQ1 compound inhibits the reaction [LDLR gene mutant form results in increased susceptibility to Cholesterol]; [LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol; [Tobacco Smoke Pollution promotes the reaction [LDLR protein affects the susceptibility to Dietary Fats]] which results in increased abundance of Cholesterol; argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]; Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]; SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]
Cholesterol results in decreased expression of LDLR mRNA
[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA; [Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA; [turmeric extract co-treated with Cholesterol] results in increased expression of LDLR mRNA; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA]; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased expression of LDLR mRNA]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased expression of LDLR mRNA]; Selenium inhibits the reaction [Cholesterol results in decreased activity of LDLR protein]; Selenium inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]; turmeric extract inhibits the reaction [Cholesterol results in decreased expression of LDLR mRNA]
[CYP27A1 protein results in increased chemical synthesis of Bile Acids and Salts] promotes the reaction [LDLR protein results in increased uptake of Cholesterol]; LDLR gene mutant form promotes the reaction [[25-hydroxycholesterol co-treated with Cholesterol] results in decreased activity of HMGCR protein]; LDLR gene mutant form results in increased susceptibility to [25-hydroxycholesterol co-treated with Cholesterol]		 CTD PMID:12477733 PMID:16271152 PMID:16317514 PMID:16477808 PMID:16937255 PMID:20578043 PMID:21535835 PMID:22659316 PMID:22841818 PMID:25263595 PMID:30273964 PMID:30950489 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lepr leptin receptor multiple interactions
increases abundance		 ISO Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased abundance of Cholesterol] CTD PMID:29988851 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G LOC103690086 uncharacterized LOC103690086 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of GBP9 mRNA CTD PMID:22129739 NCBI chr14:5,642,357...5,646,406 JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions		 ISO
EXP		 Cholesterol results in increased expression of LPL mRNA
[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in increased activity of LPL protein]		 CTD PMID:26296894 PMID:30273964 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO [Capsaicin results in decreased expression of LRP1 protein] which results in decreased uptake of Cholesterol; [Capsaicin results in decreased expression of LRP1 protein] which results in increased secretion of Cholesterol CTD PMID:21908651 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903 		JBrowse link
G Ly6e lymphocyte antigen 6 family member E multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of LY6E mRNA CTD PMID:22129739 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO Cholesterol results in increased expression of MAP1LC3B protein modified form
Cholesterol inhibits the reaction [Cadmium Chloride results in increased cleavage of MAP1LC3B protein]		 CTD PMID:28275691 PMID:29486218 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA] CTD PMID:25833014 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP [Dietary Fats co-treated with Cholesterol] results in increased expression of MAPT protein modified form; Selenium inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of MAPT protein modified form] CTD PMID:30695686 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases stability
multiple interactions		 ISO Cholesterol results in increased stability of MARCHF6 protein
Cholesterol inhibits the reaction [Betaine results in decreased stability of MARCHF6 protein]; Cholesterol inhibits the reaction [Glycerol results in decreased stability of MARCHF6 protein]; Cholesterol inhibits the reaction [MARCHF6 protein results in increased ubiquitination of and results in increased degradation of MARCHF6 protein]; MARCHF6 promotes the reaction [Cholesterol results in increased degradation of SQLE protein]		 CTD PMID:30545937 NCBI chr 2:84,533,546...84,608,743
Ensembl chr 2:84,536,669...84,608,712 		JBrowse link
G Marco macrophage receptor with collagenous structure multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of MARCO mRNA CTD PMID:22129739 NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859 		JBrowse link
G MGC105649 hypothetical LOC302884 increases expression ISO Cholesterol results in increased expression of C15ORF48 mRNA CTD PMID:26296894 NCBI chr 3:114,772,603...114,776,156
Ensembl chr 3:114,772,603...114,776,155 		JBrowse link
G Mia2 MIA SH3 domain ER export factor 2 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of MIA2 mRNA CTD PMID:22129739 NCBI chr 6:80,188,721...80,286,918
Ensembl chr 6:80,218,880...80,286,546 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of MLXIPL mRNA] CTD PMID:24440342 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Mpeg1 macrophage expressed 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of MPEG1 mRNA CTD PMID:22129739 NCBI chr 1:228,724,559...228,729,054
Ensembl chr 1:228,724,900...228,727,160 		JBrowse link
G Msr1 macrophage scavenger receptor 1 multiple interactions ISO [resveratrol results in decreased expression of MSR1 protein] which results in decreased uptake of Cholesterol CTD PMID:20372816 NCBI chr16:56,817,714...56,900,025
Ensembl chr16:56,813,791...56,900,052 		JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of MT1 mRNA CTD PMID:22129739 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A multiple interactions
increases expression		 ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of MT2 mRNA
Cholesterol results in increased expression of MT2 protein		 CTD PMID:22129739 PMID:29486218 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO Cholesterol results in increased phosphorylation of MTOR protein CTD PMID:29486218 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Mvk mevalonate kinase decreases chemical synthesis ISO MVK protein mutant form results in decreased chemical synthesis of Cholesterol CTD PMID:24073415 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400 		JBrowse link
G Nab2 Ngfi-A binding protein 2 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of NAB2 mRNA CTD PMID:22129739 NCBI chr 7:70,963,580...70,971,471
Ensembl chr 7:70,961,575...70,969,905 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of NAGLU protein CTD PMID:26606054 NCBI chr10:88,979,363...88,986,879
Ensembl chr10:88,979,383...88,986,867 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression		 ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 protein]
Cholesterol results in increased expression of NCF1 mRNA; Cholesterol results in increased expression of NCF1 protein		 CTD PMID:19028402 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 affects metabolic processing ISO NCOA2 protein affects the metabolism of Cholesterol CTD PMID:14993927 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 affects expression ISO Cholesterol affects the expression of NECTIN2 CTD PMID:28062492 NCBI chr 1:80,631,449...80,666,617
Ensembl chr 1:80,631,450...80,666,585 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions		 EXP Cholesterol results in increased expression of NFE2L2 mRNA
alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of NFE2L2 mRNA]]; alpha-Linolenic Acid inhibits the reaction [Cholesterol results in increased expression of NFE2L2 mRNA]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of NFE2L2 mRNA]]; Cholesterol promotes the reaction [Particulate Matter results in increased expression of NFE2L2 protein]; Particulate Matter promotes the reaction [Cholesterol results in increased expression of NFE2L2 mRNA]		 CTD PMID:30672636 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 ISO Cholesterol results in increased expression of NFKB1 protein
Cholesterol inhibits the reaction [irbesartan results in increased expression of NFKB1 protein]		 CTD PMID:19028402 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions
increases phosphorylation		 ISO Cholesterol inhibits the reaction [irbesartan results in increased phosphorylation of NFKBIB protein]
Cholesterol results in increased phosphorylation of NFKBIB protein		 CTD PMID:19028402 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
affects localization		 EXP
ISO		 [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein]
Cholesterol analog affects the localization of NLRP3 protein
Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein]; SMPD1 protein affects the reaction [Cholesterol analog affects the localization of NLRP3 protein]		 CTD PMID:25833014 PMID:28633109 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 increases secretion
affects localization
affects abundance
multiple interactions		 ISO NPC1 protein results in increased secretion of Cholesterol
NPC1 affects the localization of Cholesterol
NPC1 protein affects the abundance of Cholesterol
Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Cholesterol]		 CTD PMID:12183525 PMID:16174794 PMID:18483620 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of NPC1L1 mRNA CTD PMID:18356535 NCBI chr14:86,345,946...86,560,694
Ensembl chr14:86,345,953...86,560,694 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 EXP Cholesterol results in increased expression of NQO1 mRNA
alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [Cholesterol results in increased expression of NQO1 mRNA]]; Cholesterol promotes the reaction [Particulate Matter results in increased expression of NQO1 protein]; Particulate Matter promotes the reaction [Cholesterol results in increased expression of NQO1 mRNA]		 CTD PMID:30672636 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions
increases activity		 ISO [RXRB protein binds to NR1H2 protein] which affects the metabolism of Cholesterol; NR1H2 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H2 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol]
Cholesterol results in increased activity of NR1H2 protein		 CTD PMID:14993927 PMID:16415093 PMID:21543282 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
decreases expression		 ISO
EXP		 [25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Cholesterol co-treated with Ozone] results in increased lipidation of NR1H3 protein
cholesterol decreases expression of LXR mRNA in liver
NR1H3 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H3 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol]		 CTD PMID:12595494 PMID:16415093 PMID:27703007, PMID:25263431 RGD:15045610 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression
increases export		 ISO
EXP		 [FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol; Dasatinib inhibits the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol]; NR1H4 protein mutant form inhibits the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol]; SRC protein promotes the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol]
cholesterol decreases expression of Nr1h4 mRNA in liver
NR1H4 protein results in increased export of Cholesterol		 CTD PMID:30996006, PMID:25263431 RGD:15045610 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects metabolic processing ISO NR1I2 protein affects the metabolism of Cholesterol CTD PMID:15684063 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects metabolic processing
multiple interactions
affects binding		 ISO NR1I3 protein affects the metabolism of Cholesterol
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased abundance of Cholesterol
Cholesterol metabolite binds to NR1I3 protein		 CTD PMID:15684063 PMID:16051528 PMID:22101211 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 affects abundance ISO NR5A2 gene mutant form affects the abundance of Cholesterol CTD PMID:29515023 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428 		JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of OAS3 mRNA CTD PMID:22129739 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562 		JBrowse link
G Ocstamp osteoclast stimulatory transmembrane protein increases expression ISO Cholesterol results in increased expression of OCSTAMP mRNA CTD PMID:26296894 NCBI chr 3:162,073,573...162,080,487
Ensembl chr 3:162,075,340...162,080,192 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA]; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein] CTD PMID:25833014 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958 		JBrowse link
G Olr74 olfactory receptor 74 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of OLFR569 mRNA CTD PMID:22129739 NCBI chr 1:168,196,862...168,197,806
Ensembl chr 1:168,196,862...168,197,806 		JBrowse link
G Otof otoferlin multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of OTOF mRNA CTD PMID:22129739 NCBI chr 6:27,328,343...27,424,864
Ensembl chr 6:27,328,406...27,424,864 		JBrowse link
G P2rx1 purinergic receptor P2X 1 decreases activity
multiple interactions		 ISO Cholesterol deficiency results in decreased activity of P2RX1 protein
jasplakinolide inhibits the reaction [Cholesterol deficiency results in decreased activity of P2RX1 protein]		 CTD PMID:21757694 NCBI chr10:59,566,268...59,581,328
Ensembl chr10:59,566,223...59,581,325 		JBrowse link
G Pcbp1 poly(rC) binding protein 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PCBP1 mRNA CTD PMID:22129739 NCBI chr 4:118,327,185...118,329,223
Ensembl chr 4:118,327,533...118,328,602 		JBrowse link
G Pklr pyruvate kinase L/R multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of PKLR mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of PKLR mRNA CTD PMID:24440342 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592 		JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO PLD2 protein affects the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]; PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] CTD PMID:16118212 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730 		JBrowse link
G Pon1 paraoxonase 1 decreases chemical synthesis
multiple interactions
increases export
decreases activity		 ISO
EXP		 PON1 protein results in decreased chemical synthesis of Cholesterol
[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein; Atorvastatin inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]; Proanthocyanidins inhibits the reaction [[Cholesterol co-treated with Cholic Acid] results in decreased secretion of PON1 protein]
PON1 protein results in increased export of Cholesterol
Cholesterol results in decreased activity of PON1 protein		 CTD PMID:12615663 PMID:16115471 PMID:16229851 PMID:16331452 PMID:30273964 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression		 ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARA mRNA]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]]
Cholesterol results in decreased expression of PPARA mRNA
[Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [pirinixic acid binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]		 CTD PMID:11779144 PMID:12595494 PMID:21088444 PMID:24440342 PMID:25689681 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [resveratrol results in decreased abundance of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol; [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased abundance of Cholesterol; [troglitazone binds to and results in increased activity of PPARG protein] which results in increased abundance of Cholesterol; Pravastatin inhibits the reaction [[troglitazone binds to and results in increased activity of PPARG protein] which results in increased abundance of Cholesterol]
[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA; [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]; PPARG protein promotes the reaction [Niacin promotes the reaction [APOA1 protein results in increased export of Cholesterol]]; Rosiglitazone inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]		 CTD PMID:12044893 PMID:12595494 PMID:16946405 PMID:18302760 PMID:19797938 PMID:20372816 PMID:24440342 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppp1r3g protein phosphatase 1, regulatory subunit 3G multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PPP1R3G mRNA CTD PMID:22129739 NCBI chr17:29,566,032...29,570,294
Ensembl chr17:29,567,404...29,568,447 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Cholesterol results in increased expression of PSAT1 mRNA CTD PMID:26296894 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941 		JBrowse link
G Psrc1 proline and serine rich coiled-coil 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PSRC1 mRNA CTD PMID:22129739 NCBI chr 2:211,176,437...211,181,078
Ensembl chr 2:211,176,556...211,181,123 		JBrowse link
G Pycard PYD and CARD domain containing increases expression
affects localization
multiple interactions		 EXP
ISO		 Cholesterol analog results in increased expression of PYCARD mRNA
Cholesterol analog affects the localization of PYCARD protein
[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein]
[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PYCARD mRNA; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein]; SMPD1 protein affects the reaction [Cholesterol analog affects the localization of PYCARD protein]		 CTD PMID:19477266 PMID:22129739 PMID:25833014 PMID:28633109 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
increases expression		 ISO Cholesterol inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RAC1 protein]
Cholesterol results in increased expression of RAC1 mRNA; Cholesterol results in increased expression of RAC1 protein
Cholesterol inhibits the reaction [irbesartan results in increased expression of RAC1 mRNA]		 CTD PMID:19028402 PMID:21334995 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 ISO
EXP		 Cholesterol inhibits the reaction [irbesartan results in increased expression of RELA protein]
[Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein]
[methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein affects the localization of RELA protein]]
Cholesterol results in increased expression of RELA protein		 CTD PMID:19028402 PMID:23274767 PMID:25833014 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rgcc regulator of cell cycle increases expression ISO Cholesterol results in increased expression of RGCC mRNA CTD PMID:26296894 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases degradation ISO Cholesterol results in increased degradation of RGS2 protein CTD PMID:30545937 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions
increases expression		 EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Cholesterol analog results in increased expression of RIPK2 mRNA]; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of RIPK2 mRNA] CTD PMID:19477266 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735 		JBrowse link
G Rps21-ps1 ribosomal protein S21, pseudogene 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of RPS21 mRNA CTD PMID:22129739 NCBI chr 5:159,606,647...159,606,990 JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation		 ISO CYP7A1 mRNA inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6 protein]
Cholesterol inhibits the reaction [Nicotine results in increased phosphorylation of RPS6 protein]		 CTD PMID:28275691 PMID:31629012 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
increases phosphorylation		 ISO Trehalose inhibits the reaction [Cholesterol inhibits the reaction [Cadmium Chloride results in increased cleavage of RPS6KB1 protein]]; Trehalose inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6KB1 protein] CTD PMID:29486218 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 increases expression ISO Cholesterol results in increased expression of RPTOR protein CTD PMID:29486218 NCBI chr10:108,750,620...109,058,691
Ensembl chr10:108,750,620...109,058,691 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Rxrb retinoid X receptor beta multiple interactions ISO [RXRB protein binds to NR1H2 protein] which affects the metabolism of Cholesterol CTD PMID:14993927 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140 		JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of S100A8 mRNA CTD PMID:26606054 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
affects transport		 ISO [Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA; Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]
SCARB1 protein affects the transport of Cholesterol		 CTD PMID:18302760 PMID:26651060 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression
multiple interactions		 ISO Cholesterol results in increased expression of SCD1 mRNA
[lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SCD1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with cypermethrin] results in increased expression of SCD1 mRNA
Cholesterol inhibits the reaction [FGF7 protein results in increased expression of SCD mRNA]		 CTD PMID:16162944 PMID:19260826 PMID:24440342 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Shisa5 shisa family member 5 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SHISA5 mRNA CTD PMID:22129739 NCBI chr 8:117,780,992...117,795,923
Ensembl chr 8:117,780,891...117,795,919 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA; [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [Fructose results in increased abundance of Cholesterol]; Resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] CTD PMID:21212096 PMID:25833014 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 increases expression ISO Cholesterol results in increased expression of SLC1A3 mRNA CTD PMID:26296894 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363 		JBrowse link
G Slc28a3 solute carrier family 28 member 3 increases expression ISO Cholesterol results in increased expression of SLC28A3 mRNA CTD PMID:26296894 NCBI chr17:6,459,024...6,509,761
Ensembl chr17:6,459,056...6,509,799 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA; Atrazine promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; cypermethrin promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA]; Ethinyl Estradiol promotes the reaction [[lard co-treated with Cholesterol co-treated with Sucrose] results in increased expression of SLC2A2 mRNA] CTD PMID:24440342 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) multiple interactions EXP [Hydrogen Peroxide co-treated with Cholesterol] affects the localization of SLC4A1 protein; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [[Hydrogen Peroxide co-treated with Cholesterol] affects the localization of SLC4A1 protein] CTD PMID:20946910 NCBI chr10:90,296,144...90,312,401
Ensembl chr10:90,296,141...90,312,386 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Cholesterol results in increased expression of SLC7A5 mRNA CTD PMID:26296894 NCBI chr19:54,693,959...54,722,563
Ensembl chr19:54,693,959...54,722,563 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA CTD PMID:22129739 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO SMPD1 protein affects the reaction [Cholesterol analog affects the localization of CASP1 protein]; SMPD1 protein affects the reaction [Cholesterol analog affects the localization of NLRP3 protein]; SMPD1 protein affects the reaction [Cholesterol analog affects the localization of PYCARD protein]; SMPD1 protein affects the reaction [Cholesterol analog results in increased activity of CASP1 protein]; SMPD1 protein affects the reaction [Cholesterol analog results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMPD3 mRNA CTD PMID:22129739 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528 		JBrowse link
G Sort1 sortilin 1 decreases abundance
multiple interactions		 ISO SORT1 protein results in decreased abundance of Cholesterol
Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]; SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]		 CTD PMID:25805502 PMID:30950489 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312 		JBrowse link
G Sqle squalene epoxidase increases degradation
multiple interactions		 ISO Cholesterol results in increased degradation of SQLE protein
Cholesterol inhibits the reaction [Hydroxymethylglutaryl-CoA Reductase Inhibitors results in decreased degradation of SQLE protein]; MARCHF6 promotes the reaction [Cholesterol results in increased degradation of SQLE protein]		 CTD PMID:30545937 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO Cholesterol results in increased expression of SQSTM1 protein
Cholesterol inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]		 CTD PMID:28275691 PMID:29486218 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO SRC protein promotes the reaction [[FGF19 protein results in increased phosphorylation of NR1H4 protein] which results in increased export of Cholesterol] CTD PMID:30996006 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Atrazine] results in increased expression of SREBF1 mRNA; [lard co-treated with Cholesterol co-treated with Sucrose co-treated with Ethinyl Estradiol] results in increased expression of SREBF1 mRNA
[25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF1 protein		 CTD PMID:24440342 PMID:27324795 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP		 [25-hydroxycholesterol co-treated with Cholesterol] results in decreased cleavage of SREBF2 protein; [[Troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol; SREBF2 promotes the reaction [bisphenol A results in increased import of Cholesterol]
[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein; Cholesterol inhibits the reaction [[Cholesterol deficiency co-treated with Lovastatin] results in increased activity of SREBF2 protein]		 CTD PMID:16946405 PMID:20578043 PMID:27324795 PMID:28057006 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Star steroidogenic acute regulatory protein affects transport
increases transport
increases export
multiple interactions		 ISO
EXP		 STAR protein affects the transport of Cholesterol
STAR protein results in increased transport of Cholesterol
STAR protein results in increased export of Cholesterol
[[Niacin co-treated with Chromium] results in increased expression of STAR protein] which results in increased export of Cholesterol; Cholesterol inhibits the reaction [bisphenol A results in increased expression of STAR mRNA]; Cholesterol inhibits the reaction [bisphenol A results in increased expression of STAR protein]
27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]]; STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]		 CTD PMID:14630719 PMID:15819722 PMID:17934701 PMID:19900470 PMID:20083572 PMID:28859904 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO Cholesterol results in increased expression of STAT1 protein CTD PMID:17507688 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO Cholesterol inhibits the reaction [Nicotine results in decreased phosphorylation of STAT5 protein] CTD PMID:31629012 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057 		JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a multiple interactions ISO [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] promotes the reaction [SV2A protein binds to Botulinum Toxins, Type A] CTD PMID:28645175 NCBI chr 2:198,321,100...198,336,889
Ensembl chr 2:198,321,142...198,336,913 		JBrowse link
G Synpo synaptopodin multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SYNPO mRNA CTD PMID:22129739 NCBI chr18:55,863,081...55,921,412
Ensembl chr18:55,865,467...55,916,220 		JBrowse link
G Tafa2 TAFA chemokine like family member 2 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of TAFA2 mRNA CTD PMID:22129739 NCBI chr 7:66,017,066...66,496,690
Ensembl chr 7:66,017,086...66,172,360 		JBrowse link
G Tfap2e transcription factor AP-2 epsilon multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of TFAP2E mRNA CTD PMID:22129739 NCBI chr 5:144,740,950...144,761,787
Ensembl chr 5:144,740,956...144,761,787 		JBrowse link
G Tff3 trefoil factor 3 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of TFF3 mRNA CTD PMID:22129739 NCBI chr20:9,850,800...9,855,481
Ensembl chr20:9,850,803...9,855,481 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions		 ISO
EXP		 Cholesterol results in increased expression of TGFB1 mRNA
[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of TGFB1 mRNA		 CTD PMID:19110552 PMID:26606054 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions
increases expression		 ISO CLEC4E protein inhibits the reaction [Cholesterol results in increased expression of TIMP3 mRNA] CTD PMID:26296894 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of TLR4 mRNA CTD PMID:26606054 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tm4sf19 transmembrane 4 L six family member 19 increases expression ISO Cholesterol results in increased expression of TM4SF19 mRNA CTD PMID:26296894 NCBI chr11:71,607,735...71,619,108
Ensembl chr11:71,606,239...71,619,167 		JBrowse link
G Tmem97 transmembrane protein 97 affects metabolic processing ISO TMEM97 protein affects the metabolism of Cholesterol CTD PMID:18070364 NCBI chr10:65,811,455...65,820,538
Ensembl chr10:65,811,456...65,820,538 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Cholesterol inhibits the reaction [irbesartan results in increased expression of TNF mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of TNF protein]
[Cholesterol co-treated with CLEC4E] results in increased expression of TNF protein; [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein affects the localization of RELA protein]]; [methyl-beta-cyclodextrin results in decreased abundance of Cholesterol] inhibits the reaction [Polystyrenes inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]
Cholesterol analog results in increased expression of TNF mRNA
[Cholesterol co-treated with Particulate Matter] results in increased expression of TNF mRNA; [cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [Cholesterol promotes the reaction [Particulate Matter results in increased expression of TNF protein]]; Cholesterol promotes the reaction [Particulate Matter results in increased expression of TNF protein]
Cholesterol results in increased expression of TNF mRNA; Cholesterol results in increased expression of TNF protein		 CTD PMID:19028402 PMID:19477266 PMID:23274767 PMID:26296894 PMID:26606054 PMID:30672636 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Cholesterol analog results in increased expression of TNFRSF1A protein CTD PMID:19477266 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression EXP Cholesterol analog results in increased expression of TNFSF10 mRNA; Cholesterol analog results in increased expression of TNFSF10 protein CTD PMID:19477266 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression EXP Cholesterol analog results in increased expression of TRAF1 mRNA CTD PMID:19477266 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672 		JBrowse link
G Ubd ubiquitin D multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of UBD mRNA CTD PMID:22129739 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 ISO
EXP		 Cholesterol results in increased expression of VCAM1 mRNA; Cholesterol results in increased expression of VCAM1 protein
[cocoa butter co-treated with Sodium Cholate co-treated with Cholesterol] results in increased expression of VCAM1 mRNA
Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 protein]		 CTD PMID:19028402 PMID:26606054 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vdr vitamin D receptor affects binding
affects abundance		 ISO Cholesterol metabolite binds to VDR protein
VDR gene SNP affects the abundance of Cholesterol		 CTD PMID:16051528 PMID:25498546 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of VEGFA protein CTD PMID:16034455 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vwf von Willebrand factor multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein] CTD PMID:25833014 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523 		JBrowse link
G Zbp1 Z-DNA binding protein 1 multiple interactions ISO [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of ZBP1 mRNA CTD PMID:22129739 NCBI chr 3:171,276,062...171,292,062
Ensembl chr 3:171,276,062...171,286,537 		JBrowse link
cholesterol sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO cholesteryl sulfate results in decreased expression of CYP11A1 mRNA CTD PMID:18490834 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO cholesteryl sulfate results in decreased expression of STAR mRNA; cholesteryl sulfate results in decreased expression of STAR protein CTD PMID:18490834 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases abundance ISO SULT2B1 protein results in increased abundance of cholesteryl sulfate CTD PMID:27052460 NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508 		JBrowse link
cholesteryl arachidonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions
decreases abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate
LIPG gene mutant form results in decreased abundance of cholesteryl arachidonate		 CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
cholesteryl linoleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions
affects abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate
LIPG gene mutant form affects the abundance of cholesteryl linoleate		 CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
cholesteryl linolenate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions
increases abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate
LIPG gene mutant form results in increased abundance of cholesteryl linolenate		 CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
cholesteryl myristate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl myristate CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type affects abundance
multiple interactions		 ISO LIPG gene mutant form affects the abundance of cholesteryl myristate
[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl myristate		 CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
cholesteryl oleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl oleate CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions
increases abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl oleate
LIPG gene mutant form results in increased abundance of cholesteryl oleate		 CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
cholesteryl palmitate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl palmitate CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions
increases abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl palmitate
LIPG gene mutant form results in increased abundance of cholesteryl palmitate		 CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
cholesteryl stearate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipg lipase G, endothelial type decreases abundance ISO LIPG gene mutant form results in decreased abundance of cholesterol stearate CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Desmosterol results in increased expression of ABCA1 mRNA CTD PMID:19260826 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Clec4e C-type lectin domain family 4, member E increases activity ISO Desmosterol results in increased activity of CLEC4E protein CTD PMID:26296894 NCBI chr 4:156,271,087...156,276,243
Ensembl chr 4:156,270,920...156,276,304 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases metabolic processing ISO CYP27A1 protein results in increased metabolism of Desmosterol CTD PMID:14622972 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases metabolic processing
multiple interactions		 ISO DHCR24 protein results in increased metabolism of Desmosterol
[DHCR24 protein results in increased metabolism of Desmosterol] which results in increased abundance of Cholesterol		 CTD PMID:23042211 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Desmosterol results in decreased expression of HMGCR protein CTD PMID:19260826 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Desmosterol analog; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased abundance of Desmosterol analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO Desmosterol results in decreased expression of INSIG1 protein CTD PMID:19260826 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO Desmosterol results in decreased expression of LDLR protein CTD PMID:19260826 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases stability ISO Desmosterol results in increased stability of MARCHF6 protein CTD PMID:30545937 NCBI chr 2:84,533,546...84,608,743
Ensembl chr 2:84,536,669...84,608,712 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Desmosterol results in increased expression of SCD1 mRNA CTD PMID:19260826 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Desmosterol results in increased expression of SREBF1 mRNA; Desmosterol results in increased expression of SREBF1 protein CTD PMID:19260826 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
fusidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP
ISO		 Fusidic Acid results in decreased activity of ABCB11 protein
Fusidic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:12106615 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27676153 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin] CTD PMID:26888941 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Fusidic Acid results in decreased expression of and results in decreased activity of ABCC2 protein CTD PMID:12106615 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Fusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid] CTD PMID:27676153 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:26888941 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
decreases activity		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid results in decreased activity of SLCO1B3 protein		 CTD PMID:26888941 PMID:27676153 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] CTD PMID:27676153 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
high-density lipoprotein cholesterol term browser