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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5alpha-cholestane
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Accession:CHEBI:35515 term browser browse the term
Definition:The 5alpha-stereoisomer of cholestane.
Synonyms:related_synonym: Formula=C27H48;   InChI=1S/C27H48/c1-19(2)9-8-10-20(3)23-14-15-24-22-13-12-21-11-6-7-17-26(21,4)25(22)16-18-27(23,24)5/h19-25H,6-18H2,1-5H3/t20-,21-,22+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=XIIAYQZJNBULGD-XWLABEFZSA-N;   SMILES=[H][C@]12CCCC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])CC2)[C@H](C)CCCC(C)C;   alpha-cholestane
 alt_id: CHEBI:20650
 xref: Beilstein:2051806;   CAS:481-21-0;   HMDB:HMDB0041632;   Reaxys:2051806


show annotations for term's descendants           Sort by:
 
(5alpha)-cholestan-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases secretion ISO CYP27A1 protein results in increased secretion of Cholestanol CTD PMID:12117727 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 increases hydroxylation ISO CYP46A1 protein results in increased hydroxylation of Cholestanol CTD PMID:14640697 NCBI chr 6:127,243,315...127,274,765
Ensembl chr 6:127,243,315...127,274,760 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions ISO [Cholestanol co-treated with NAD] binds to HSD17B10 protein CTD PMID:25526675 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation ISO SULT2A1 protein results in increased sulfation of Cholestanol CTD PMID:21839837 NCBI chr 1:75,451,178...75,508,142 JBrowse link
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases activity ISO 4,4-dimethylcholesta-8,14,24-trienol results in increased activity of NR1H3 protein CTD PMID:9603267 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
5,6alpha-epoxy-5alpha-cholestan-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor increases phosphorylation EXP cholesterol alpha-oxide results in increased phosphorylation of EGFR protein CTD PMID:20466046 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases metabolic processing
multiple interactions		 ISO EPHX1 protein results in increased metabolism of cholesterol alpha-oxide
disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]; Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]		 CTD PMID:2043152 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO cholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein] CTD PMID:20466046 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20466046 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP2 mRNA CTD PMID:20466046 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP9 mRNA CTD PMID:20466046 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions		 EXP cholesterol alpha-oxide results in increased phosphorylation of MTOR protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]		 CTD PMID:20466046 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
fusidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP
ISO		 Fusidic Acid results in decreased activity of ABCB11 protein
Fusidic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:12106615 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27676153 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin] CTD PMID:26888941 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Fusidic Acid results in decreased expression of and results in decreased activity of ABCC2 protein CTD PMID:12106615 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:26888941 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Fusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid] CTD PMID:27676153 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:26888941 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
decreases activity		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid results in decreased activity of SLCO1B3 protein		 CTD PMID:26888941 PMID:27676153 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] CTD PMID:27676153 NCBI chr 9:88,801,344...88,808,465 JBrowse link
zymosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases metabolic processing ISO CYP27A1 protein results in increased metabolism of zymosterol CTD PMID:14622972 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases abundance ISO MSMO1 protein results in decreased abundance of zymosterol metabolite CTD PMID:23125191 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              lipid 17493
                steroid 13347
                  steroid fundamental parent 13017
                    cholestane 349
                      5alpha-cholestane 22
                        (5alpha)-cholestan-3beta-ol + 4
                        26,27-dehydrozymosterol 0
                        3beta-hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-carboxylic acid 0
                        3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylic acid 0
                        4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol 1
                        4alpha-methyllathosterone 0
                        5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                        5,6alpha-epoxy-5alpha-cholestane 0
                        5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                        5alpha-cholest-7-ene + 0
                        5alpha-cholest-8-en-3beta-ol 0
                        5alpha-cholesta-7,24-dien-3beta-ol 0
                        5alpha-cholesta-8,14-dien-3beta-ol 0
                        5alpha-cholestan-3-one 0
                        5alpha-cholestane-3beta,5,6beta-triol 0
                        5alpha-cholestane-5,6beta-diol 0
                        epidihydrocholesterin 0
                        eurysterol A 0
                        eurysterol A sulfonic acid 0
                        eurysterol B 0
                        eurysterol B sulfonic acid 0
                        fusidic acid 8
                        methyl spongoate 0
                        zymosterol + 2
                        zymosterol intermediate 2 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic polycyclic compound 16570
                                  steroid 13347
                                    steroid fundamental parent 13017
                                      cholestane 349
                                        5alpha-cholestane 22
                                          (5alpha)-cholestan-3beta-ol + 4
                                          26,27-dehydrozymosterol 0
                                          3beta-hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-carboxylic acid 0
                                          3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylic acid 0
                                          4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol 1
                                          4alpha-methyllathosterone 0
                                          5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
                                          5,6alpha-epoxy-5alpha-cholestane 0
                                          5,6beta-epoxy-5alpha-cholestan-3beta-ol 0
                                          5alpha-cholest-7-ene + 0
                                          5alpha-cholest-8-en-3beta-ol 0
                                          5alpha-cholesta-7,24-dien-3beta-ol 0
                                          5alpha-cholesta-8,14-dien-3beta-ol 0
                                          5alpha-cholestan-3-one 0
                                          5alpha-cholestane-3beta,5,6beta-triol 0
                                          5alpha-cholestane-5,6beta-diol 0
                                          epidihydrocholesterin 0
                                          eurysterol A 0
                                          eurysterol A sulfonic acid 0
                                          eurysterol B 0
                                          eurysterol B sulfonic acid 0
                                          fusidic acid 8
                                          methyl spongoate 0
                                          zymosterol + 2
                                          zymosterol intermediate 2 0
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