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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases secretion |
ISO |
CYP27A1 protein results in increased secretion of Cholestanol |
CTD |
PMID:12117727 |
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NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
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G |
Cyp46a1 |
cytochrome P450, family 46, subfamily a, polypeptide 1 |
increases hydroxylation |
ISO |
CYP46A1 protein results in increased hydroxylation of Cholestanol |
CTD |
PMID:14640697 |
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NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
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G |
Hsd17b10 |
hydroxysteroid (17-beta) dehydrogenase 10 |
multiple interactions |
ISO |
[Cholestanol co-treated with NAD] binds to HSD17B10 protein |
CTD |
PMID:25526675 |
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NCBI chr X:21,696,796...21,699,241
Ensembl chr X:21,696,772...21,699,241
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G |
Sult2a1 |
sulfotransferase family 2A member 1 |
increases sulfation |
ISO |
SULT2A1 protein results in increased sulfation of Cholestanol |
CTD |
PMID:21839837 |
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NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
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G |
Nr1h3 |
nuclear receptor subfamily 1, group H, member 3 |
increases activity |
ISO |
4,4-dimethylcholesta-8,14,24-trienol results in increased activity of NR1H3 protein |
CTD |
PMID:9603267 |
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NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
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G |
Egfr |
epidermal growth factor receptor |
increases phosphorylation |
EXP |
cholesterol alpha-oxide results in increased phosphorylation of EGFR protein |
CTD |
PMID:20466046 |
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NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
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G |
Ephx1 |
epoxide hydrolase 1 |
increases metabolic processing multiple interactions |
ISO |
EPHX1 protein results in increased metabolism of cholesterol alpha-oxide disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]; Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide] |
CTD |
PMID:2043152 |
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NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
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G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
cholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] |
CTD |
PMID:2043152 |
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NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
EXP |
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:20466046 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
EXP |
cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:20466046 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mmp2 |
matrix metallopeptidase 2 |
increases expression |
EXP |
cholesterol alpha-oxide results in increased expression of MMP2 mRNA |
CTD |
PMID:20466046 |
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NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
increases expression |
EXP |
cholesterol alpha-oxide results in increased expression of MMP9 mRNA |
CTD |
PMID:20466046 |
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NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mtor |
mechanistic target of rapamycin kinase |
increases phosphorylation multiple interactions |
EXP |
cholesterol alpha-oxide results in increased phosphorylation of MTOR protein RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein] |
CTD |
PMID:20466046 |
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NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity multiple interactions |
EXP ISO |
Fusidic Acid results in decreased activity of ABCB11 protein Fusidic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:12106615 PMID:20829430 PMID:23956101 PMID:24014644 PMID:27676153 |
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NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
Fusidic Acid inhibits the reaction [ABCB1 protein results in increased export of Digoxin] |
CTD |
PMID:26888941 |
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NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
EXP |
Fusidic Acid results in decreased expression of and results in decreased activity of ABCC2 protein |
CTD |
PMID:12106615 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
multiple interactions |
ISO |
Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] |
CTD |
PMID:26888941 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions |
ISO |
Fusidic Acid inhibits the reaction [SLC10A1 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:27676153 |
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NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
EXP |
Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium] |
CTD |
PMID:26888941 |
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NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
multiple interactions decreases activity |
EXP ISO |
Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium] Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium] Fusidic Acid results in decreased activity of SLCO1B3 protein |
CTD |
PMID:26888941 PMID:27676153 |
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NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions |
ISO |
Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol] |
CTD |
PMID:27676153 |
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NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
increases metabolic processing |
ISO |
CYP27A1 protein results in increased metabolism of zymosterol |
CTD |
PMID:14622972 |
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NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
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G |
Msmo1 |
methylsterol monooxygenase 1 |
decreases abundance |
ISO |
MSMO1 protein results in decreased abundance of zymosterol metabolite |
CTD |
PMID:23125191 |
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NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
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