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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hallucinogen
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Accession:CHEBI:35499 term browser browse the term
Definition:Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking.
Synonyms:related_synonym: hallucinogenic agents;   hallucinogenic drugs;   hallucinogens;   psychedelic agents;   psychedelics


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11-hydroxy-Delta(9)-tetrahydrocannabinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions EXP 11-hydroxy-delta(9)-tetrahydrocannabinol binds to and results in increased activity of TRPV2 protein CTD PMID:18550765 NCBI chr10:48,903,540...48,925,036
Ensembl chr10:48,903,540...48,925,030
JBrowse link
5-methoxy-N,N-diisopropyltryptamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
multiple interactions
ISO 5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein
[5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion
CTD PMID:26599973 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole CTD PMID:26599973 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 increases metabolic processing EXP CYP2D1 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine CTD PMID:18191824 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases metabolic processing EXP CYP2D2 protein results in increased metabolism of 5-methoxy-N,N-diisopropyltryptamine CTD PMID:18191824 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2E1 protein] which results in decreased metabolism of Chlorzoxazone CTD PMID:26599973 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
benzydamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation
multiple interactions
ISO FMO1 protein results in increased oxidation of Benzydamine
Benzydamine inhibits the reaction [FMO1 protein results in increased chemical synthesis of clozapine N-oxide]
CTD PMID:18809730, PMID:21435388 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation
multiple interactions
ISO FMO2 protein results in increased oxidation of Benzydamine
[FMO2 protein results in increased oxidation of Benzydamine] which results in increased chemical synthesis of benzydamine N-oxide
CTD PMID:26062974 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
affects metabolic processing
increases metabolic processing
increases oxidation
ISO Benzydamine inhibits the reaction [FMO3 protein results in increased chemical synthesis of clozapine N-oxide]
FMO3 gene polymorphism affects the metabolism of Benzydamine
FMO3 protein results in increased metabolism of Benzydamine
FMO3 protein results in increased oxidation of Benzydamine
CTD PMID:17142560, PMID:18809730, PMID:21435388 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Benzydamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
ibogaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Ibogaine results in decreased activity of KCNH2 protein CTD PMID:23707769, PMID:24307198 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Ibogaine results in decreased activity of SCN5A protein CTD PMID:23707769 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Sec24d SEC24 homolog D, COPII coat complex component increases response to substance ISO SEC24D protein results in increased susceptibility to Ibogaine CTD PMID:27555326 NCBI chr 2:227,455,704...227,562,801
Ensembl chr 2:227,455,722...227,562,319
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases expression
ISO Ibogaine inhibits the reaction [SLC6A3 protein mutant form results in decreased import of Dopamine]; Ibogaine promotes the reaction [SLC6A3 protein results in increased import of Dopamine]
Ibogaine results in increased expression of SLC6A3 protein
CTD PMID:27555326 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
lysergic acid diethylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Lysergic Acid Diethylamide results in increased expression of FOS mRNA CTD PMID:10521585 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions
affects binding
ISO 2-aminoindan analog inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein]; Lysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Lysergic Acid Diethylamide binds to HTR2B protein] CTD PMID:14659797, PMID:29458138 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 affects binding ISO Lysergic Acid Diethylamide binds to HTR6 protein CTD PMID:21866910 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link
mescaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grm2 glutamate metabotropic receptor 2 multiple interactions ISO [Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to Mescaline CTD PMID:21366332 NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            central nervous system drug 16449
              psychotropic drug 15058
                hallucinogen 18
                  4-\{2-[(2-hydroxybenzyl)amino]ethyl\}-2,5-dimethoxybenzonitrile 0
                  5-methoxy-N,N-diisopropyltryptamine 6
                  5-methoxy-N,N-dimethyltryptamine 0
                  Delta(9)-tetrahydrocannabinol + 1
                  baeocystin 0
                  benzydamine 4
                  bufotenin + 0
                  ibogaine + 4
                  lysergic acid diethylamide 3
                  mescaline 1
                  norbaeocystin 0
                  psilocin + 0
                  psilocybin 0
                  psilocybin(1-) 0
                  rolicyclidine 0
                  tenocyclidine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.