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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diuretic
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Accession:CHEBI:35498 term browser browse the term
Definition:An agent that promotes the excretion of urine through its effects on kidney function.
Synonyms:related_synonym: diuretics


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5-(N,N-hexamethylene)amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of DDIT3 mRNA CTD PMID:19302589 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 affects expression ISO 5-(N,N-hexamethylene)amiloride affects the expression of HSP90B1 mRNA CTD PMID:19302589 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa5 heat shock protein 5 affects expression ISO 5-(N,N-hexamethylene)amiloride affects the expression of HSPA5 mRNA CTD PMID:19302589 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of PPP1R15A mRNA CTD PMID:19302589 NCBI chr 7:45,522,917...45,526,268
Ensembl chr 7:45,522,916...45,526,268
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 5-(N,N-hexamethylene)amiloride results in increased expression of PTGS2 mRNA CTD PMID:19302589 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Serpinb1a serine (or cysteine) peptidase inhibitor, clade B, member 1a multiple interactions ISO 5-(N,N-hexamethylene)amiloride results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form CTD PMID:25447644 NCBI chr13:32,842,092...32,853,206
Ensembl chr13:32,842,092...32,851,185
JBrowse link
8-(3-chlorostyryl)caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions
increases response to substance
ISO
EXP
8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine
CTD PMID:11172060, PMID:15641640, PMID:18608257, PMID:19966059, PMID:21195062 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
multiple interactions
EXP DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
CTD PMID:11172060 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] CTD PMID:8577368, PMID:10199625 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Nts neurotensin multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 NCBI chr10:102,481,756...102,490,418
Ensembl chr10:102,481,756...102,490,486
JBrowse link
acetazolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 increases expression EXP Acetazolamide results in increased expression of ABCA1 mRNA CTD PMID:19274763 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895
JBrowse link
G Akap17b A kinase (PRKA) anchor protein 17B increases expression EXP Acetazolamide results in increased expression of AKAP17B mRNA CTD PMID:19274763 NCBI chr  X:36,608,173...36,645,465
Ensembl chr  X:36,608,314...36,645,395
JBrowse link
G Akap9 A kinase (PRKA) anchor protein (yotiao) 9 increases expression EXP Acetazolamide results in increased expression of AKAP9 mRNA CTD PMID:19274763 NCBI chr 5:3,927,736...4,080,204
Ensembl chr 5:3,928,054...4,081,310
JBrowse link
G Ammecr1l AMME chromosomal region gene 1-like increases expression EXP Acetazolamide results in increased expression of AMMECR1L mRNA CTD PMID:19274763 NCBI chr18:31,758,504...31,784,083
Ensembl chr18:31,759,826...31,782,743
JBrowse link
G Anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A increases expression EXP Acetazolamide results in increased expression of ANP32A mRNA CTD PMID:19274763 NCBI chr 9:62,341,343...62,378,804
Ensembl chr 9:62,341,293...62,378,812
JBrowse link
G Aqp1 aquaporin 1 decreases expression ISO Acetazolamide results in decreased expression of AQP1 protein CTD PMID:17219999 NCBI chr 6:55,336,299...55,348,555
Ensembl chr 6:55,336,432...55,348,555
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Acetazolamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr10:80,016,672...80,031,471
Ensembl chr10:80,016,653...80,031,472
JBrowse link
G Arid2 AT rich interactive domain 2 (ARID, RFX-like) increases expression EXP Acetazolamide results in increased expression of ARID2 mRNA CTD PMID:19274763 NCBI chr15:96,287,522...96,405,463
Ensembl chr15:96,287,518...96,404,992
JBrowse link
G Brd4 bromodomain containing 4 increases expression EXP Acetazolamide results in increased expression of BRD4 mRNA CTD PMID:19274763 NCBI chr17:32,196,272...32,284,743
Ensembl chr17:32,196,274...32,284,722
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions
decreases activity
ISO Acetazolamide binds to and results in decreased activity of CA1 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein] CTD PMID:11430635, PMID:17826101, PMID:19231207, PMID:28117934, PMID:28251759, PMID:29131470, PMID:29283199, PMID:29457667, PMID:29975450, PMID:29992664, PMID:30291660, PMID:30368973, PMID:30431690, PMID:30537031 NCBI chr 3:14,766,214...14,808,365
Ensembl chr 3:14,766,216...14,808,368
JBrowse link
G Car12 carbonic anhydrase 12 decreases activity
multiple interactions
ISO Acetazolamide results in decreased activity of CA12 protein
Acetazolamide binds to and results in decreased activity of CA12 protein
CTD PMID:21851094, PMID:28251759 NCBI chr 9:66,712,296...66,766,845
Ensembl chr 9:66,713,686...66,766,845
JBrowse link
G Car13 carbonic anhydrase 13 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA13 protein CTD PMID:28251759 NCBI chr 3:14,641,727...14,663,002
Ensembl chr 3:14,641,727...14,663,002
JBrowse link
G Car14 carbonic anhydrase 14 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA14 protein CTD PMID:28251759 NCBI chr 3:95,897,768...95,905,117
Ensembl chr 3:95,897,768...95,904,691
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO Acetazolamide binds to and results in decreased activity of CA2 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein] CTD PMID:11430635, PMID:16858005, PMID:17826101, PMID:19231207, PMID:21851094, PMID:28117934, PMID:28251759, PMID:29131470, PMID:29283199, PMID:29457667, PMID:29975450, PMID:29992664, PMID:30291660, PMID:30368973, PMID:30431690, PMID:30537031 NCBI chr 3:14,886,269...14,900,770
Ensembl chr 3:14,886,273...14,900,770
JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 3:14,863,538...14,872,381
Ensembl chr 3:14,863,512...14,872,523
JBrowse link
G Car4 carbonic anhydrase 4 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA4 protein CTD PMID:28251759 NCBI chr11:84,957,754...84,966,054
Ensembl chr11:84,957,786...84,966,044
JBrowse link
G Car5a carbonic anhydrase 5a, mitochondrial multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5A protein CTD PMID:28251759 NCBI chr 8:121,916,135...121,944,912
Ensembl chr 8:121,916,126...121,944,904
JBrowse link
G Car5b carbonic anhydrase 5b, mitochondrial multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA5B protein CTD PMID:28251759 NCBI chr  X:163,976,822...164,028,010
Ensembl chr  X:163,976,822...164,027,997
JBrowse link
G Car6 carbonic anhydrase 6 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA6 protein CTD PMID:28251759 NCBI chr 4:150,187,015...150,201,135
Ensembl chr 4:150,187,015...150,201,332
JBrowse link
G Car7 carbonic anhydrase 7 multiple interactions ISO Acetazolamide binds to and results in decreased activity of CA7 protein CTD PMID:28251759 NCBI chr 8:104,534,694...104,550,347
Ensembl chr 8:104,534,689...104,550,343
JBrowse link
G Car9 carbonic anhydrase 9 decreases activity
multiple interactions
ISO Acetazolamide results in decreased activity of CA9 protein
Acetazolamide binds to and results in decreased activity of CA9 protein
CTD PMID:21851094, PMID:28251759 NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein] CTD PMID:21040473 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cbx3 chromobox 3 increases expression EXP Acetazolamide results in increased expression of CBX3 mRNA CTD PMID:19274763 NCBI chr 6:51,470,154...51,483,704
Ensembl chr 6:51,470,360...51,483,704
JBrowse link
G Ccnd2 cyclin D2 increases expression EXP Acetazolamide results in increased expression of CCND2 mRNA CTD PMID:19274763 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193
JBrowse link
G Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) increases expression EXP Acetazolamide results in increased expression of CD47 mRNA CTD PMID:19274763 NCBI chr16:49,851,328...49,912,503
Ensembl chr16:49,800,533...49,915,010
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression EXP Acetazolamide results in increased expression of CIRBP mRNA CTD PMID:19274763 NCBI chr10:80,165,990...80,172,786
Ensembl chr10:80,165,985...80,172,786
JBrowse link
G Clcn3 chloride channel, voltage-sensitive 3 increases expression EXP Acetazolamide results in increased expression of CLCN3 mRNA CTD PMID:19274763 NCBI chr 8:60,910,389...60,983,317
Ensembl chr 8:60,910,389...60,983,300
JBrowse link
G Ddx3x DEAD box helicase 3, X-linked increases expression EXP Acetazolamide results in increased expression of DDX3X mRNA CTD PMID:19274763 NCBI chr  X:13,280,496...13,293,988
Ensembl chr  X:13,280,970...13,294,052
JBrowse link
G Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 increases expression EXP Acetazolamide results in increased expression of DDX6 mRNA CTD PMID:19274763 NCBI chr 9:44,602,983...44,640,731
Ensembl chr 9:44,604,892...44,640,731
JBrowse link
G Dsc2 desmocollin 2 increases expression EXP Acetazolamide results in increased expression of DSC2 mRNA CTD PMID:19274763 NCBI chr18:20,030,633...20,059,554
Ensembl chr18:20,030,633...20,059,554
JBrowse link
G Glg1 golgi apparatus protein 1 increases expression EXP Acetazolamide results in increased expression of GLG1 mRNA CTD PMID:19274763 NCBI chr 8:111,153,284...111,259,210
Ensembl chr 8:111,154,421...111,259,216
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) increases expression EXP Acetazolamide results in increased expression of GLUL mRNA CTD PMID:19274763 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Htra1 HtrA serine peptidase 1 increases expression EXP Acetazolamide results in increased expression of HTRA1 mRNA CTD PMID:19274763 NCBI chr 7:130,936,203...130,985,658
Ensembl chr 7:130,936,111...130,985,660
JBrowse link
G Igf1r insulin-like growth factor I receptor increases expression EXP Acetazolamide results in increased expression of IGF1R mRNA CTD PMID:19274763 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Itpr2 inositol 1,4,5-triphosphate receptor 2 increases expression EXP Acetazolamide results in increased expression of ITPR2 mRNA CTD PMID:19274763 NCBI chr 6:146,108,299...146,502,258
Ensembl chr 6:146,108,299...146,502,223
JBrowse link
G Mab21l2 mab-21-like 2 decreases expression EXP Acetazolamide results in decreased expression of MAB21L2 mRNA CTD PMID:19274763 NCBI chr 3:86,546,050...86,548,283
Ensembl chr 3:86,545,581...86,548,629
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP Acetazolamide results in increased expression of MAP3K1 mRNA CTD PMID:19274763 NCBI chr13:111,746,428...111,818,269
Ensembl chr13:111,746,428...111,808,993
JBrowse link
G Mt1 metallothionein 1 decreases expression EXP Acetazolamide results in decreased expression of MT1 mRNA CTD PMID:19274763 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit increases expression EXP Acetazolamide results in increased expression of NAA15 mRNA CTD PMID:19274763 NCBI chr 3:51,416,016...51,475,985
Ensembl chr 3:51,415,148...51,476,507
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 increases expression EXP Acetazolamide results in increased expression of NDRG1 mRNA CTD PMID:19274763 NCBI chr15:66,929,318...66,969,641
Ensembl chr15:66,929,318...66,969,640
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 increases expression EXP Acetazolamide results in increased expression of NRIP1 mRNA CTD PMID:19274763 NCBI chr16:76,287,403...76,373,827
Ensembl chr16:76,287,400...76,373,827
JBrowse link
G Peg3 paternally expressed 3 increases expression EXP Acetazolamide results in increased expression of PEG3 mRNA CTD PMID:19274763 NCBI chr 7:6,703,892...6,730,462
Ensembl chr 7:6,703,892...6,730,431
JBrowse link
G Pou2f1 POU domain, class 2, transcription factor 1 increases expression EXP Acetazolamide results in increased expression of POU2F1 mRNA CTD PMID:19274763 NCBI chr 1:165,865,150...166,002,749
Ensembl chr 1:165,865,154...166,002,678
JBrowse link
G Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform increases expression EXP Acetazolamide results in increased expression of PPM1B mRNA CTD PMID:19274763 NCBI chr17:84,956,741...85,023,992
Ensembl chr17:84,956,741...85,023,991
JBrowse link
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform increases expression EXP Acetazolamide results in increased expression of PPP3CA mRNA CTD PMID:19274763 NCBI chr 3:136,669,714...136,937,727
Ensembl chr 3:136,670,124...136,937,727
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression EXP Acetazolamide results in increased expression of RBM39 mRNA CTD PMID:19274763 NCBI chr 2:156,147,239...156,180,238
Ensembl chr 2:156,147,239...156,180,238
JBrowse link
G Rbmx RNA binding motif protein, X chromosome increases expression EXP Acetazolamide results in increased expression of RBMX mRNA CTD PMID:19274763 NCBI chr  X:57,383,348...57,393,046
Ensembl chr  X:57,383,530...57,393,036
JBrowse link
G Satb1 special AT-rich sequence binding protein 1 increases expression EXP Acetazolamide results in increased expression of SATB1 mRNA CTD PMID:19274763 NCBI chr17:51,736,187...51,833,290
Ensembl chr17:51,736,187...51,833,290
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Acetazolamide results in increased expression of SC5D mRNA CTD PMID:19274763 NCBI chr 9:42,251,592...42,264,300
Ensembl chr 9:42,251,595...42,264,256
JBrowse link
G Schip1 schwannomin interacting protein 1 increases expression EXP Acetazolamide results in increased expression of SCHIP1 mRNA CTD PMID:19274763 NCBI chr 3:68,064,802...68,626,482
Ensembl chr 3:68,064,802...68,626,481
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Acetazolamide results in increased expression of SDC4 mRNA CTD PMID:19274763 NCBI chr 2:164,424,247...164,443,188
Ensembl chr 2:164,424,247...164,443,887
JBrowse link
G Sema4b sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B increases expression EXP Acetazolamide results in increased expression of SEMA4B mRNA CTD PMID:19274763 NCBI chr 7:80,186,870...80,226,646
Ensembl chr 7:80,186,841...80,226,527
JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases expression EXP Acetazolamide results in increased expression of SF3B1 mRNA CTD PMID:19274763 NCBI chr 1:54,985,169...55,027,501
Ensembl chr 1:54,985,169...55,027,481
JBrowse link
G Sfmbt2 Scm-like with four mbt domains 2 increases expression EXP Acetazolamide results in increased expression of SFMBT2 mRNA CTD PMID:19274763 NCBI chr 2:10,370,440...10,595,253
Ensembl chr 2:10,370,510...10,595,253
JBrowse link
G Shox2 short stature homeobox 2 increases expression EXP Acetazolamide results in increased expression of SHOX2 mRNA CTD PMID:19274763 NCBI chr 3:66,971,723...66,981,771
Ensembl chr 3:66,971,727...66,981,771
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 increases expression EXP Acetazolamide results in increased expression of SMARCC1 mRNA CTD PMID:19274763 NCBI chr 9:110,132,024...110,240,178
Ensembl chr 9:110,117,708...110,240,178
JBrowse link
G Stx3 syntaxin 3 increases expression EXP Acetazolamide results in increased expression of STX3 mRNA CTD PMID:19274763 NCBI chr19:11,775,118...11,821,569
Ensembl chr19:11,775,118...11,819,403
JBrowse link
G Styx serine/threonine/tyrosine interaction protein increases expression EXP Acetazolamide results in increased expression of STYX mRNA CTD PMID:19274763 NCBI chr14:45,351,186...45,376,884
Ensembl chr14:45,351,093...45,422,820
JBrowse link
G Tia1 cytotoxic granule-associated RNA binding protein 1 increases expression EXP Acetazolamide results in increased expression of TIA1 mRNA CTD PMID:19274763 NCBI chr 6:86,404,203...86,433,405
Ensembl chr 6:86,404,219...86,433,405
JBrowse link
G Tmem30b transmembrane protein 30B increases expression EXP Acetazolamide results in increased expression of TMEM30B mRNA CTD PMID:19274763 NCBI chr12:73,543,114...73,546,395
Ensembl chr12:73,543,402...73,546,392
JBrowse link
G Trim25 tripartite motif-containing 25 increases expression EXP Acetazolamide results in increased expression of TRIM25 mRNA CTD PMID:19274763 NCBI chr11:88,999,403...89,020,294
Ensembl chr11:88,999,376...89,020,293
JBrowse link
G Umod uromodulin increases expression ISO Acetazolamide results in increased expression of UMOD protein CTD PMID:2655449 NCBI chr 7:119,462,708...119,479,262
Ensembl chr 7:119,462,711...119,479,282
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 increases expression EXP Acetazolamide results in increased expression of WNK1 mRNA CTD PMID:19274763 NCBI chr 6:119,923,969...120,038,695
Ensembl chr 6:119,923,969...120,038,672
JBrowse link
G Zfp322a zinc finger protein 322A increases expression EXP Acetazolamide results in increased expression of ZFP322A mRNA CTD PMID:19274763 NCBI chr13:23,353,103...23,369,208
Ensembl chr13:23,353,103...23,369,208
JBrowse link
G Zfp617 zinc finger protein 617 increases expression EXP Acetazolamide results in increased expression of ZFP617 mRNA CTD PMID:19274763 NCBI chr 8:71,922,825...71,934,630
Ensembl chr 8:71,908,635...71,934,629
JBrowse link
amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan affects expression ISO Amiloride affects the expression of ACAN mRNA CTD PMID:20454829 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
increases expression
ISO Amiloride inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]
Amiloride results in increased expression of AGT protein modified form
CTD PMID:7357812, PMID:14630723 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions ISO Amiloride results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of AKT1 protein] CTD PMID:15607733, PMID:16059913 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alb albumin multiple interactions ISO Amiloride inhibits the reaction [ALB protein results in increased expression of CCL2 protein] CTD PMID:11340305 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Aoc1 amine oxidase, copper-containing 1 affects binding
multiple interactions
decreases activity
ISO Amiloride binds to AOC1 protein
Amiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
Amiloride results in decreased activity of AOC1 protein
CTD PMID:2217167, PMID:8144586 NCBI chr 6:48,895,255...48,909,188
Ensembl chr 6:48,872,896...48,909,188
JBrowse link
G Asic3 acid-sensing (proton-gated) ion channel 3 affects response to substance EXP ASIC3 protein affects the susceptibility to Amiloride CTD PMID:12037186 NCBI chr 5:24,413,451...24,417,840
Ensembl chr 5:24,413,392...24,417,835
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide multiple interactions ISO Amiloride inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 3:101,576,219...101,604,707
Ensembl chr 3:101,576,219...101,604,684
JBrowse link
G Atp6v1b1 ATPase, H+ transporting, lysosomal V1 subunit B1 multiple interactions ISO [Furosemide co-treated with Amiloride] results in increased expression of ATP6V1B1 protein CTD PMID:17311909 NCBI chr 6:83,743,017...83,758,855
Ensembl chr 6:83,742,990...83,758,855
JBrowse link
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit multiple interactions EXP
ISO
Amiloride inhibits the reaction [CACNA1H protein results in increased transport of Calcium] CTD PMID:9930755, PMID:11897840 NCBI chr17:25,374,285...25,436,334
Ensembl chr17:25,374,285...25,433,783
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions EXP Amiloride inhibits the reaction [Acids results in increased secretion of CALCA protein] CTD PMID:20100279 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15607733, PMID:16059913 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:15607733, PMID:16059913 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:16059913 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
ISO Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
Amiloride inhibits the reaction [ALB protein results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 protein]
Amiloride results in decreased expression of CCL2 mRNA; Amiloride results in decreased expression of CCL2 protein
CTD PMID:11340305, PMID:12107048 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions EXP Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:11420121 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Amiloride results in decreased expression of CCNB1 protein CTD PMID:9458082 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator increases activity EXP Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G Col2a1 collagen, type II, alpha 1 affects expression ISO Amiloride affects the expression of COL2A1 mRNA CTD PMID:20454829 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Amiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cxcl2 chemokine (C-X-C motif) ligand 2 multiple interactions EXP Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL2 protein] CTD PMID:11420121 NCBI chr 5:90,903,899...90,905,938
Ensembl chr 5:90,903,871...90,905,938
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein affects the localization of CYCS protein] CTD PMID:15607733 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Amiloride inhibits the reaction [Tunicamycin results in increased expression of DDIT3] CTD PMID:20015086 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dysf dysferlin decreases expression ISO Amiloride results in decreased expression of DYSF mRNA CTD PMID:15535137 NCBI chr 6:84,008,361...84,211,060
Ensembl chr 6:84,008,590...84,211,060
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation EXP Amiloride results in increased phosphorylation of EIF2A protein CTD PMID:20015086 NCBI chr 3:58,525,821...58,557,501
Ensembl chr 3:58,525,821...58,557,501
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases phosphorylation ISO Amiloride results in decreased phosphorylation of ERBB2 protein CTD PMID:16059913 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions EXP Amiloride inhibits the reaction [Tunicamycin results in increased phosphorylation of and results in increased activity of ERN1 protein] CTD PMID:20015086 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression
multiple interactions
ISO
EXP
Amiloride results in increased expression of FOS mRNA
Amiloride inhibits the reaction [Acids results in increased expression of and results in increased localization of FOS protein]
CTD PMID:12730611, PMID:16769263 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Grip1 glutamate receptor interacting protein 1 affects response to substance ISO GRIP1 gene SNP affects the susceptibility to Amiloride CTD PMID:25622337 NCBI chr10:119,453,238...120,087,267
Ensembl chr10:119,453,830...120,087,261
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions EXP Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein] CTD PMID:20015086 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA]
Amiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein]
CTD PMID:11420121, PMID:12070711 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il12b interleukin 12b multiple interactions EXP Amiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Amiloride inhibits the reaction [IL1B protein results in increased expression of SELE protein]; Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Amiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Itgal integrin alpha L multiple interactions EXP Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr 7:127,296,139...127,335,137
Ensembl chr 7:127,296,260...127,335,138
JBrowse link
G Klk1 kallikrein 1 multiple interactions
increases response to substance
EXP KLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]
KLK1 protein results in increased susceptibility to Amiloride
CTD PMID:18086683 NCBI chr 7:44,225,360...44,229,622
Ensembl chr 7:44,225,360...44,229,618
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein] CTD PMID:12065299 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12065299 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Amiloride inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK8 protein] CTD PMID:19815690 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Amiloride inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK9 protein] CTD PMID:19815690 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Myf5 myogenic factor 5 increases expression ISO Amiloride results in increased expression of MYF5 mRNA CTD PMID:15535137 NCBI chr10:107,482,908...107,486,927
Ensembl chr10:107,482,908...107,486,134
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions ISO Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of and results in decreased expression of NFKBIA protein] CTD PMID:12107048 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Lipopolysaccharides inhibits the reaction [Amiloride results in increased expression of NOS2] CTD PMID:21356098 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:15607733, PMID:16059913 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 decreases phosphorylation ISO Amiloride results in decreased phosphorylation of PDPK1 protein CTD PMID:16059913 NCBI chr17:24,073,680...24,155,619
Ensembl chr17:24,073,680...24,150,924
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO Amiloride results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr 5:147,270,097...147,275,848
Ensembl chr 5:147,269,959...147,275,848
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel multiple interactions ISO Amiloride results in decreased activity of [PKD2 protein binds to PKD2 protein]; Amiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein] CTD PMID:19193631 NCBI chr 5:104,453,982...104,505,819
Ensembl chr 5:104,459,450...104,505,819
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
decreases activity
ISO Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein]
Amiloride results in decreased activity of PLAU protein
CTD PMID:8921802, PMID:11454671, PMID:14644129 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO Amiloride inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA]; Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA] CTD PMID:12070711 NCBI chr 7:24,460,937...24,475,970
Ensembl chr 7:24,462,484...24,475,968
JBrowse link
G Plg plasminogen multiple interactions ISO Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein] CTD PMID:14644129 NCBI chr17:12,378,609...12,419,384
Ensembl chr17:12,378,608...12,419,385
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases phosphorylation
multiple interactions
ISO Amiloride results in decreased phosphorylation of PPP1CA protein
Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein]
CTD PMID:16059913 NCBI chr19:4,192,174...4,195,419
Ensembl chr19:4,192,065...4,195,420
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Amiloride inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:17237260 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299, PMID:12107048 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Scnn1a sodium channel, nonvoltage-gated 1 alpha multiple interactions
affects activity
ISO
EXP
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
[farglitazar co-treated with Amiloride] results in increased expression of SCNN1A mRNA
Amiloride affects the activity of SCNN1A protein
CTD PMID:8617496, PMID:15475592, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr 6:125,314,271...125,344,943
Ensembl chr 6:125,320,659...125,344,943
JBrowse link
G Scnn1b sodium channel, nonvoltage-gated 1 beta multiple interactions
affects activity
ISO
EXP
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
Amiloride affects the activity of SCNN1B protein
CTD PMID:8617496, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr 7:121,865,038...121,918,728
Ensembl chr 7:121,865,038...121,918,514
JBrowse link
G Scnn1g sodium channel, nonvoltage-gated 1 gamma affects activity
multiple interactions
EXP
ISO
Amiloride affects the activity of SCNN1G protein
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
CTD PMID:8617496, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr 7:121,734,420...121,768,482
Ensembl chr 7:121,734,479...121,768,475
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO Amiloride inhibits the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:12107048 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Slc12a4 solute carrier family 12, member 4 multiple interactions EXP Amiloride inhibits the reaction [SLC12A4 protein results in increased transport of Potassium] CTD PMID:11703599 NCBI chr 8:105,943,590...105,966,149
Ensembl chr 8:105,943,590...105,966,097
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Amiloride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Slc26a4 solute carrier family 26, member 4 multiple interactions ISO [Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein CTD PMID:17311909 NCBI chr12:31,519,814...31,560,055
Ensembl chr12:31,519,827...31,559,969
JBrowse link
G Slc31a1 solute carrier family 31, member 1 multiple interactions ISO Amiloride inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 4:62,360,583...62,391,769
Ensembl chr 4:62,360,727...62,391,769
JBrowse link
G Slc47a1 solute carrier family 47, member 1 decreases activity
multiple interactions
ISO Amiloride results in decreased activity of SLC47A1 protein
Amiloride inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:16928787, PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Amiloride inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,301,627...61,342,860
Ensembl chr11:61,301,631...61,342,860
JBrowse link
G Slc52a3 solute carrier protein family 52, member 3 multiple interactions ISO Amiloride inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr 2:151,996,511...152,009,258
Ensembl chr 2:151,996,511...152,009,258
JBrowse link
G Slc9a2 solute carrier family 9 (sodium/hydrogen exchanger), member 2 multiple interactions ISO [Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Chlorides; [Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Sodium CTD PMID:10958346 NCBI chr 1:40,681,712...40,768,885
Ensembl chr 1:40,680,574...40,769,273
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein]; Lipopolysaccharides inhibits the reaction [Amiloride results in increased expression of TNF] CTD PMID:10198263, PMID:21356098 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 multiple interactions ISO Amiloride promotes the reaction [TNFSF10 protein affects the localization of CYCS protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP9 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:15607733, PMID:16059913 NCBI chr 3:27,317,077...27,339,665
Ensembl chr 3:27,317,028...27,342,427
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions EXP Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] CTD PMID:15843607 NCBI chr 1:14,872,644...14,918,862
Ensembl chr 1:14,872,648...14,918,862
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions ISO Amiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein] CTD PMID:19193631 NCBI chr 9:95,705,072...95,750,386
Ensembl chr 9:95,705,082...95,750,375
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 decreases activity EXP Amiloride results in decreased activity of TRPC6 protein CTD PMID:11179201 NCBI chr 9:8,543,867...8,680,752
Ensembl chr 9:8,544,142...8,680,741
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Amiloride results in decreased expression of VEGFA mRNA; Amiloride results in decreased expression of VEGFA protein CTD PMID:16884771 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Amiloride inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:20015086 NCBI chr11:5,520,641...5,525,993
Ensembl chr11:5,520,659...5,525,893
JBrowse link
azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a2 solute carrier family 12, member 2 decreases activity
multiple interactions
EXP
ISO
azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:15517342, PMID:29959396 NCBI chr18:57,878,512...57,946,821
Ensembl chr18:57,878,678...57,946,821
JBrowse link
bendroflumethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B affects expression ISO Bendroflumethiazide affects the expression of APOB protein CTD PMID:2344503 NCBI chr12:7,977,629...8,016,839
Ensembl chr12:7,977,648...8,016,835
JBrowse link
G Ren1 renin 1 structural increases expression ISO Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Slc12a3 solute carrier family 12, member 3 increases response to substance ISO SLC12A3 protein results in increased susceptibility to Bendroflumethiazide CTD PMID:18480177 NCBI chr 8:94,329,109...94,366,222
Ensembl chr 8:94,329,201...94,366,214
JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 decreases activity
increases secretion
EXP Bendroflumethiazide results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 decreases activity
increases secretion
EXP Bendroflumethiazide results in decreased activity of SLC22A8 protein
SLC22A8 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
G Tpmt thiopurine methyltransferase decreases activity ISO Bendroflumethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr13:47,021,987...47,043,338
Ensembl chr13:47,022,482...47,044,737
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Bendroflumethiazide results in decreased expression of VEGFC protein CTD PMID:20625077 NCBI chr 8:54,077,532...54,186,454
Ensembl chr 8:54,077,606...54,187,096
JBrowse link
bumetanide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 increases transport ISO ABCC4 protein results in increased transport of Bumetanide CTD PMID:17939016 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator decreases activity ISO Bumetanide results in decreased activity of CFTR protein CTD PMID:15131065, PMID:15802612 NCBI chr 6:18,170,687...18,322,770
Ensembl chr 6:18,170,687...18,322,768
JBrowse link
G F2rl1 coagulation factor II (thrombin) receptor-like 1 multiple interactions ISO Bumetanide inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] CTD PMID:11804840 NCBI chr13:95,511,718...95,525,240
Ensembl chr13:95,511,732...95,525,227
JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 affects expression ISO Bumetanide affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr17:37,270,234...37,274,485
Ensembl chr17:37,270,220...37,274,484
JBrowse link
G Ins1 insulin I multiple interactions EXP Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:22872759 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression EXP Bumetanide results in increased expression of PTGS1 mRNA CTD PMID:14504926 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ren1 renin 1 structural multiple interactions
increases expression
increases secretion
ISO
EXP
[Bumetanide co-treated with trandolapril] results in increased expression of REN protein; Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]; Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]
Bumetanide results in increased expression of REN mRNA
Bumetanide results in increased expression of REN protein
CTD PMID:6756707, PMID:7040495, PMID:14504926, PMID:16635047 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Slc12a2 solute carrier family 12, member 2 increases response to substance
decreases activity
multiple interactions
EXP
ISO
SLC12A2 results in increased susceptibility to Bumetanide
Bumetanide results in decreased activity of SLC12A2 protein
Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
[calyculin A results in increased phosphorylation of SLC12A2 protein] inhibits the reaction [Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]]
Bumetanide results in decreased activity of SLC12A2 protein; Bumetanide results in decreased activity of SLC12A2 protein mutant form
CTD PMID:12556450, PMID:14630635, PMID:16709721, PMID:17259435, PMID:22872759, PMID:25817889, PMID:29959396 NCBI chr18:57,878,512...57,946,821
Ensembl chr18:57,878,678...57,946,821
JBrowse link
G Slc12a7 solute carrier family 12, member 7 decreases activity EXP Bumetanide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr13:73,733,052...73,816,754
Ensembl chr13:73,733,094...73,816,754
JBrowse link
G Slc17a3 solute carrier family 17 (sodium phosphate), member 3 affects transport ISO SLC17A3 gene SNP affects the transport of Bumetanide CTD PMID:21282933 NCBI chr13:23,836,922...23,860,718
Ensembl chr13:23,839,434...23,860,716
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 multiple interactions
decreases activity
ISO Bumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Bumetanide results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr10:77,032,269...77,050,432
Ensembl chr10:77,032,241...77,061,002
JBrowse link
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 multiple interactions
increases transport
ISO Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
SLC22A7 protein results in increased transport of Bumetanide
CTD PMID:15901346 NCBI chr17:46,432,185...46,438,477
Ensembl chr17:46,432,183...46,438,457
JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 multiple interactions ISO Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
CTD PMID:10224140, PMID:11306713 NCBI chr19:8,591,254...8,611,835
Ensembl chr19:8,591,254...8,611,835
JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 9230019H11Rik RIKEN cDNA 9230019H11 gene multiple interactions ISO Caffeine inhibits the reaction [resveratrol results in increased expression of ULBP3 protein] CTD PMID:23445485 NCBI chr10:3,119,841...3,129,546
Ensembl chr10:3,119,841...3,129,546
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Acan aggrecan decreases expression ISO Caffeine results in decreased expression of ACAN mRNA CTD PMID:29966748, PMID:32663519 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099
JBrowse link
G Acat2 acetyl-Coenzyme A acetyltransferase 2 decreases expression ISO Caffeine results in decreased expression of ACAT2 mRNA CTD PMID:11793227 NCBI chr17:12,943,042...12,960,725
Ensembl chr17:12,942,890...12,960,747
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 decreases methylation
increases expression
ISO Caffeine results in decreased methylation of ACE promoter
Caffeine results in increased expression of ACE mRNA; Caffeine results in increased expression of ACE protein
CTD PMID:30423288 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein] CTD PMID:28465162 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 increases expression ISO Caffeine results in increased expression of ACIN1 mRNA CTD PMID:11793227 NCBI chr14:54,642,161...54,686,965
Ensembl chr14:54,642,161...54,686,931
JBrowse link
G Acly ATP citrate lyase increases expression ISO Caffeine results in increased expression of ACLY mRNA CTD PMID:30776459 NCBI chr11:100,476,352...100,528,000
Ensembl chr11:100,476,353...100,528,000
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression ISO Caffeine results in increased expression of ACSL3 mRNA CTD PMID:11793227 NCBI chr 1:78,657,825...78,707,743
Ensembl chr 1:78,657,825...78,707,743
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO Caffeine results in decreased expression of ACSL4 protein CTD PMID:31195006 NCBI chr  X:142,317,993...142,390,802
Ensembl chr  X:142,317,993...142,390,535
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta increases expression ISO Caffeine results in increased expression of ACTA2 mRNA CTD PMID:29055810 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Actb actin, beta decreases expression ISO Caffeine results in decreased expression of ACTB protein CTD PMID:31195006 NCBI chr 5:142,903,115...142,907,976
Ensembl chr 5:142,903,115...142,906,754
JBrowse link
G Actbl2 actin, beta-like 2 increases expression ISO Caffeine results in increased expression of ACTBL2 protein CTD PMID:31195006 NCBI chr13:111,255,013...111,257,749
Ensembl chr13:111,255,013...111,257,749
JBrowse link
G Actl6b actin-like 6B increases expression ISO Caffeine results in increased expression of ACTL6B protein CTD PMID:31195006 NCBI chr 5:137,553,361...137,569,582
Ensembl chr 5:137,553,517...137,569,582
JBrowse link
G Actr1a ARP1 actin-related protein 1A, centractin alpha multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr19:46,376,813...46,395,741
Ensembl chr19:46,376,811...46,395,748
JBrowse link
G Ada adenosine deaminase increases expression ISO Caffeine results in increased expression of ADA protein CTD PMID:6149265 NCBI chr 2:163,726,571...163,750,239
Ensembl chr 2:163,726,584...163,750,239
JBrowse link
G Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) increases expression ISO Caffeine results in increased expression of ADAMTS5 mRNA CTD PMID:31874197 NCBI chr16:85,858,157...85,901,125
Ensembl chr16:85,856,173...85,901,828
JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression ISO Caffeine results in decreased expression of ADARB1 mRNA CTD PMID:20864626 NCBI chr10:77,290,727...77,418,292
Ensembl chr10:77,290,726...77,418,270
JBrowse link
G Adcy5 adenylate cyclase 5 decreases expression ISO Caffeine results in decreased expression of ADCY5 mRNA CTD PMID:26367767 NCBI chr16:35,154,494...35,305,743
Ensembl chr16:35,154,877...35,305,738
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr 8:88,272,190...88,329,965
Ensembl chr 8:88,272,403...88,329,962
JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr 8:83,900,098...83,941,954
Ensembl chr 8:83,900,105...83,941,954
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression ISO Caffeine results in increased expression of ADIPOR2 mRNA CTD PMID:22583948 NCBI chr 6:119,353,150...119,417,699
Ensembl chr 6:119,353,150...119,417,704
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
decreases expression
decreases activity
increases expression
EXP
ISO
[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine; [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA; [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA
Caffeine deficiency results in decreased expression of ADORA1 mRNA
Caffeine results in decreased activity of ADORA1 protein
Caffeine results in decreased expression of ADORA1 mRNA
Caffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]; Caffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]
Caffeine results in increased expression of ADORA1 protein
CTD PMID:3003150, PMID:7996441, PMID:10401785, PMID:12153486, PMID:15708489, PMID:22164264, PMID:23611293, PMID:29107002, PMID:29882086 NCBI chr 1:134,199,215...134,235,457
Ensembl chr 1:134,199,223...134,235,431
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
decreases expression
multiple interactions
decreases activity
increases response to substance
affects binding
EXP
ISO
ADORA2A protein affects the susceptibility to Caffeine
Caffeine results in decreased expression of ADORA2A mRNA
Caffeine results in decreased expression of ADORA2A mRNA; Caffeine results in decreased expression of ADORA2A protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]
ADORA2A polymorphism affects the susceptibility to Caffeine
Caffeine results in decreased activity of ADORA2A protein
ADORA2A polymorphism results in increased susceptibility to Caffeine; ADORA2A SNP results in increased susceptibility to Caffeine
Caffeine analog binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to and results in decreased activity of ADORA2A protein; Caffeine binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to ADORA2A protein
ADORA2A protein results in increased susceptibility to Caffeine
CTD PMID:10214707, PMID:11172060, PMID:12077927, PMID:12825092, PMID:15452191, PMID:16221767, PMID:16470403, PMID:16771831, PMID:18305461, PMID:20520601, PMID:21950736, PMID:23611293, PMID:26367767, PMID:30555576, PMID:30825513 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Adora2b adenosine A2b receptor multiple interactions
decreases expression
ISO ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
Caffeine results in decreased expression of ADORA2B mRNA
CTD PMID:22701600, PMID:26367767 NCBI chr11:62,248,984...62,266,452
Ensembl chr11:62,248,984...62,266,453
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) increases expression ISO Caffeine results in increased expression of AGT protein CTD PMID:30423288 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
decreases expression
ISO Caffeine results in increased expression of AGTR1A
Caffeine results in decreased expression of AGTR1A mRNA
CTD PMID:25986755, PMID:30423288 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression ISO Caffeine results in decreased expression of AGTR2 mRNA; Caffeine results in decreased expression of AGTR2 protein CTD PMID:25986755, PMID:30423288 NCBI chr  X:21,484,624...21,488,833
Ensembl chr  X:21,484,544...21,489,164
JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase decreases expression ISO Caffeine results in decreased expression of AHCY protein CTD PMID:31195006 NCBI chr 2:155,059,310...155,074,497
Ensembl chr 2:155,059,310...155,074,497
JBrowse link
G Akap9 A kinase (PRKA) anchor protein (yotiao) 9 decreases expression ISO Caffeine results in decreased expression of AKAP9 protein CTD PMID:31195006 NCBI chr 5:3,927,736...4,080,204
Ensembl chr 5:3,928,054...4,081,310
JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of AKR1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 4:116,636,510...116,651,674
Ensembl chr 4:116,636,510...116,651,680
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
affects expression
decreases expression
decreases phosphorylation
increases phosphorylation
decreases response to substance
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]
Caffeine affects the expression of AKT1 mRNA
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
Caffeine results in decreased expression of AKT1 mRNA; Caffeine results in decreased expression of AKT1 protein modified form
Caffeine results in decreased phosphorylation of AKT1 protein
AKT1 results in decreased susceptibility to Caffeine
CTD PMID:15126379, PMID:18201823, PMID:21081844, PMID:21561856, PMID:22974838, PMID:29966748, PMID:30528684 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression ISO Caffeine results in decreased expression of ALDH18A1 mRNA CTD PMID:11793227 NCBI chr19:40,550,257...40,588,463
Ensembl chr19:40,550,257...40,588,463
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA] CTD PMID:20230807 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 increases expression ISO Caffeine results in increased expression of ALDH9A1 mRNA CTD PMID:20864626 NCBI chr 1:167,349,963...167,368,530
Ensembl chr 1:167,349,991...167,368,532
JBrowse link
G Aldoa aldolase A, fructose-bisphosphate multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA CTD PMID:28843594 NCBI chr 7:126,795,234...126,800,994
Ensembl chr 7:126,795,234...126,800,751
Ensembl chr 7:126,795,234...126,800,751
JBrowse link
G Alms1 ALMS1, centrosome and basal body associated decreases expression ISO Caffeine results in decreased expression of ALMS1 mRNA CTD PMID:25868845 NCBI chr 6:85,587,498...85,726,611
Ensembl chr 6:85,587,531...85,702,753
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney decreases expression ISO Caffeine results in decreased expression of ALPL mRNA CTD PMID:30423288, PMID:31874197 NCBI chr 4:137,741,731...137,796,384
Ensembl chr 4:137,741,733...137,796,384
JBrowse link
G Ang angiogenin, ribonuclease, RNase A family, 5 decreases expression ISO Caffeine results in decreased expression of ANG mRNA CTD PMID:11793227 NCBI chr14:51,091,077...51,102,009
Ensembl chr14:51,091,150...51,102,009
JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Caffeine results in decreased expression of ANKRD37 mRNA CTD PMID:20864626 NCBI chr 8:45,996,908...46,000,414
Ensembl chr 8:45,996,902...46,005,707
JBrowse link
G Anxa11 annexin A11 decreases expression ISO Caffeine results in decreased expression of ANXA11 protein CTD PMID:31195006 NCBI chr14:25,842,127...25,886,804
Ensembl chr14:25,842,156...25,886,804
Ensembl chr14:25,842,156...25,886,804
Ensembl chr14:25,842,156...25,886,804
JBrowse link
G Anxa4 annexin A4 decreases expression ISO Caffeine results in decreased expression of ANXA4 protein CTD PMID:31195006 NCBI chr 6:86,736,840...86,793,634
Ensembl chr 6:86,736,840...86,793,584
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions
decreases expression
ISO [Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein
Caffeine results in decreased expression of APOA1 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Apoa2 apolipoprotein A-II multiple interactions
decreases expression
ISO [Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein
Caffeine results in decreased expression of APOA2 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 1:171,221,564...171,226,379
Ensembl chr 1:171,225,054...171,226,379
JBrowse link
G Apob apolipoprotein B multiple interactions
decreases expression
ISO [Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein
[Caffeine co-treated with Dietary Fats] results in increased expression of APOB mRNA
Caffeine results in decreased expression of APOB mRNA
CTD PMID:16324916, PMID:25868845, PMID:29800656 NCBI chr12:7,977,629...8,016,839
Ensembl chr12:7,977,648...8,016,835
JBrowse link
G Apoc1 apolipoprotein C-I multiple interactions
decreases expression
ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein
Caffeine results in decreased expression of APOC1 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 7:19,689,480...19,692,659
Ensembl chr 7:19,689,481...19,692,660
JBrowse link
G Apoc2 apolipoprotein C-II multiple interactions
decreases expression
ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein
Caffeine results in decreased expression of APOC2 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 7:19,671,579...19,677,941
Ensembl chr 7:19,671,579...19,677,941
JBrowse link
G Apoc3 apolipoprotein C-III multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein CTD PMID:16324916 NCBI chr 9:46,233,050...46,235,636
Ensembl chr 9:46,232,933...46,235,636
JBrowse link
G Apom apolipoprotein M decreases expression ISO Caffeine results in decreased expression of APOM mRNA CTD PMID:25868845 NCBI chr17:35,128,997...35,131,801
Ensembl chr17:35,128,997...35,132,050
JBrowse link
G Arcn1 archain 1 decreases expression ISO Caffeine results in decreased expression of ARCN1 protein CTD PMID:31195006 NCBI chr 9:44,742,143...44,767,808
Ensembl chr 9:44,741,564...44,767,845
JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr11:59,211,412...59,228,267
Ensembl chr11:59,211,412...59,228,270
JBrowse link
G Arl6ip1 ADP-ribosylation factor-like 6 interacting protein 1 increases expression ISO Caffeine results in increased expression of ARL6IP1 mRNA CTD PMID:11793227 NCBI chr 7:118,118,890...118,129,625
Ensembl chr 7:118,118,891...118,129,662
JBrowse link
G Arrb2 arrestin, beta 2 increases expression ISO Caffeine results in increased expression of ARRB2 mRNA CTD PMID:20864626 NCBI chr11:70,432,485...70,440,828
Ensembl chr11:70,432,635...70,440,828
JBrowse link
G Asns asparagine synthetase decreases expression ISO Caffeine results in decreased expression of ASNS mRNA CTD PMID:18444173 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atg7 autophagy related 7 increases response to substance EXP ATG7 protein results in increased susceptibility to Caffeine; ATG7 results in increased susceptibility to Caffeine CTD PMID:21081844 NCBI chr 6:114,643,127...114,860,604
Ensembl chr 6:114,643,097...114,860,614
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions
decreases activity
ISO
EXP
[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
ATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]
CTD PMID:10531013, PMID:11507241, PMID:15975956, PMID:18347191, PMID:19028473, PMID:19038232, PMID:20734998, PMID:20888899, PMID:22927544, PMID:23274516, PMID:31168028 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 affects response to substance EXP ATP2A2 protein affects the susceptibility to Caffeine CTD PMID:19328205 NCBI chr 5:122,453,513...122,502,225
Ensembl chr 5:122,453,513...122,502,225
JBrowse link
G Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 decreases expression ISO Caffeine results in decreased expression of ATP5MF mRNA CTD PMID:11793227 NCBI chr 5:145,183,704...145,191,541
Ensembl chr 5:145,183,698...145,192,062
JBrowse link
G Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V0C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0C mRNA] CTD PMID:20230807 NCBI chr17:24,163,865...24,169,678
Ensembl chr17:24,163,866...24,169,702
JBrowse link
G Atp6v1b2 ATPase, H+ transporting, lysosomal V1 subunit B2 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V1B2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V1B2 mRNA] CTD PMID:20230807 NCBI chr 8:69,088,736...69,113,718
Ensembl chr 8:69,088,646...69,113,711
JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression ISO Caffeine results in decreased expression of ATPAF1 mRNA CTD PMID:20864626 NCBI chr 4:115,784,828...115,811,923
Ensembl chr 4:115,784,812...115,822,655
JBrowse link
G Atr ataxia telangiectasia and Rad3 related affects activity
multiple interactions
ISO Caffeine affects the activity of ATR protein
[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
CTD PMID:11507241, PMID:15975956, PMID:18158334, PMID:20734998 NCBI chr 9:95,857,597...95,953,217
Ensembl chr 9:95,857,597...95,951,781
JBrowse link
G Atrn attractin multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 2:130,906,430...131,030,333
Ensembl chr 2:130,906,495...131,030,333
JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr10:122,448,499...122,453,453
Ensembl chr10:122,448,499...122,453,452
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO Caffeine results in increased expression of BASP1 protein CTD PMID:31195006 NCBI chr15:25,363,277...25,413,764
Ensembl chr15:25,363,277...25,413,764
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO
EXP
Caffeine results in increased expression of BAX protein
[Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA
CTD PMID:12811820, PMID:12907610, PMID:31756439 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions ISO Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein] CTD PMID:19028473 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions EXP [Caffeine co-treated with bisphenol A] results in decreased expression of BCL2L1 mRNA CTD PMID:31756439 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions ISO Caffeine inhibits the reaction [aluminum chloride results in decreased expression of BDNF mRNA] CTD PMID:26339337 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
EXP
ISO
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein]
CTD PMID:30555576 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bglap bone gamma carboxyglutamate protein decreases expression ISO Caffeine results in decreased expression of BGLAP mRNA CTD PMID:30423288, PMID:31874197 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bhmt betaine-homocysteine methyltransferase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr13:93,616,891...93,637,758
Ensembl chr13:93,616,675...93,637,961
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase multiple interactions ISO [Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form CTD PMID:21670593 NCBI chr 2:127,800,197...127,831,859
Ensembl chr 2:127,801,122...127,831,865
JBrowse link
G C1rb complement component 1, r subcomponent B multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 6:124,570,430...124,581,044
Ensembl chr 6:124,570,294...124,581,171
JBrowse link
G C1s2 complement component 1, s subcomponent 2 multiple interactions EXP Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr 6:124,624,625...124,636,085
Ensembl chr 6:124,624,625...124,636,085
JBrowse link
G C2cd5 C2 calcium-dependent domain containing 5 increases expression ISO Caffeine results in increased expression of C2CD5 mRNA CTD PMID:20864626 NCBI chr 6:143,010,920...143,100,155
Ensembl chr 6:143,010,920...143,100,141
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression ISO Caffeine results in increased expression of CAD protein CTD PMID:6149265 NCBI chr 5:31,054,620...31,078,479
Ensembl chr 5:31,054,780...31,078,479
JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CALM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr12:100,199,435...100,209,824
Ensembl chr12:100,199,435...100,209,814
JBrowse link
G Calu calumenin decreases expression ISO Caffeine results in decreased expression of CALU mRNA CTD PMID:11793227 NCBI chr 6:29,348,106...29,376,675
Ensembl chr 6:29,348,069...29,377,110
JBrowse link
G Cand1 cullin associated and neddylation disassociated 1 decreases expression ISO Caffeine results in decreased expression of CAND1 protein CTD PMID:31195006 NCBI chr10:119,198,812...119,240,055
Ensembl chr10:119,199,255...119,240,055
JBrowse link
G Capn1 calpain 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr19:5,988,545...6,015,825
Ensembl chr19:5,988,545...6,015,897
JBrowse link
G Capn2 calpain 2 decreases expression ISO Caffeine results in decreased expression of CAPN2 protein CTD PMID:31195006 NCBI chr 1:182,467,253...182,517,610
Ensembl chr 1:182,467,260...182,517,608
JBrowse link
G Casp2 caspase 2 multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP2 protein] CTD PMID:16777994 NCBI chr 6:42,264,902...42,282,508
Ensembl chr 6:42,264,985...42,282,508
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
increases cleavage
increases activity
affects cleavage
ISO
EXP
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein; Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP3 protein
Caffeine results in decreased expression of CASP3 protein modified form
Caffeine results in increased expression of CASP3 mRNA
Caffeine results in increased cleavage of CASP3 protein
Caffeine results in increased activity of CASP3 protein
[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
Caffeine affects the cleavage of CASP3 protein
CTD PMID:12378022, PMID:12395097, PMID:12907610, PMID:15537744, PMID:16522534, PMID:16777994, PMID:18201823, PMID:18283038, PMID:19242509, PMID:19490937, PMID:19815060, PMID:21081844, PMID:21229324, PMID:31874197 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP9 protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
CTD PMID:16522534, PMID:16777994, PMID:20230807 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase multiple interactions
decreases expression
increases expression
EXP
ISO
Caffeine inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein]
Caffeine results in decreased expression of CAT mRNA
Caffeine results in increased expression of CAT protein
[Caffeine co-treated with Cadmium Chloride] results in decreased activity of CAT protein; [Caffeine co-treated with Cadmium Chloride] results in increased expression of CAT protein
CTD PMID:22154906, PMID:23099337, PMID:25868845 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav1 caveolin 1, caveolae protein increases expression ISO Caffeine results in increased expression of CAV1 protein CTD PMID:31195006 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Cav3 caveolin 3 decreases expression ISO Caffeine results in decreased expression of CAV3 mRNA CTD PMID:25868845 NCBI chr 6:112,459,505...112,472,872
Ensembl chr 6:112,459,505...112,472,872
JBrowse link
G Cbx5 chromobox 5 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr15:103,191,546...103,239,904
Ensembl chr15:103,191,544...103,239,816
JBrowse link
G Ccdc124 coiled-coil domain containing 124 increases expression ISO Caffeine results in increased expression of CCDC124 protein CTD PMID:31195006 NCBI chr 8:70,868,226...70,873,490
Ensembl chr 8:70,868,227...70,873,935
JBrowse link
G Ccdc174 coiled-coil domain containing 174 decreases expression ISO Caffeine results in decreased expression of CCDC174 mRNA CTD PMID:20864626 NCBI chr 6:91,843,154...91,899,849
Ensembl chr 6:91,878,053...91,899,843
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 decreases expression
increases expression
ISO Caffeine results in decreased expression of CCL3 mRNA
Caffeine results in increased expression of CCL3 mRNA
CTD PMID:28089782 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression
EXP
ISO
Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein]
Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein]
Caffeine results in increased expression of CCNB1 protein
CTD PMID:9098629, PMID:19038232, PMID:20025956 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:15126379 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccnf cyclin F multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CCNF mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNF mRNA] CTD PMID:20230807 NCBI chr17:24,223,230...24,251,409
Ensembl chr17:24,222,198...24,251,484
JBrowse link
G Ccng1 cyclin G1 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr11:40,748,552...40,755,309
Ensembl chr11:40,748,552...40,755,311
JBrowse link
G Ccnl2 cyclin L2 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 4:155,810,219...155,824,543
Ensembl chr 4:155,812,489...155,824,543
JBrowse link
G Cct8 chaperonin containing Tcp1, subunit 8 (theta) decreases expression ISO Caffeine results in decreased expression of CCT8 protein CTD PMID:31195006 NCBI chr16:87,483,325...87,495,869
Ensembl chr16:87,483,326...87,495,873
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cd59b CD59b antigen increases expression ISO Caffeine results in increased expression of CD59 protein CTD PMID:31195006 NCBI chr 2:104,069,781...104,085,790
Ensembl chr 2:104,069,849...104,091,187
JBrowse link
G Cd9 CD9 antigen decreases expression ISO Caffeine results in decreased expression of CD9 protein CTD PMID:31195006 NCBI chr 6:125,460,266...125,494,760
Ensembl chr 6:125,460,266...125,494,791
JBrowse link
G Cdc14b CDC14 cell division cycle 14B multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr13:64,192,545...64,274,988
Ensembl chr13:64,189,268...64,275,290
JBrowse link
G Cdc25b cell division cycle 25B increases expression ISO Caffeine results in increased expression of CDC25B mRNA CTD PMID:20864626 NCBI chr 2:131,186,436...131,198,511
Ensembl chr 2:131,186,949...131,198,497
JBrowse link
G Cdc25c cell division cycle 25C decreases expression
multiple interactions
ISO Caffeine results in decreased expression of CDC25C protein
Caffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein]; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein]
CTD PMID:11835680, PMID:15975956 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Caffeine results in increased expression of CDH1 mRNA CTD PMID:20864626 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh11 cadherin 11 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr 8:102,632,095...102,785,493
Ensembl chr 8:102,632,095...102,785,642
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO
EXP
Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDK1 protein]; Caffeine results in decreased phosphorylation of and results in increased activity of CDK1 protein
Caffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]
CTD PMID:9098629, PMID:11835680, PMID:15975956, PMID:19038232 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases activity ISO Caffeine results in decreased activity of CDK2 protein CTD PMID:11835680 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
EXP
ISO
Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein]
Caffeine results in decreased expression of CDK4 mRNA
CTD PMID:11793227, PMID:15126379 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions ISO
EXP
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [entinostat results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]
CTD PMID:17977830, PMID:18223691, PMID:18347191, PMID:19735649, PMID:21840268, PMID:22927544, PMID:23274516, PMID:30555576 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha decreases expression
affects expression
increases expression
ISO Caffeine results in decreased expression of CEBPA mRNA
Caffeine affects the expression of CEBPA mRNA
Caffeine results in increased expression of CEBPA mRNA
CTD PMID:23727198, PMID:30423288, PMID:30528684, PMID:30776459 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta decreases expression ISO Caffeine results in decreased expression of CEBPB mRNA CTD PMID:30528684 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr19:21,778,340...21,858,360
Ensembl chr19:21,778,342...21,858,360
JBrowse link
G Cetn3 centrin 3 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr13:81,780,636...81,797,155
Ensembl chr13:81,783,077...81,797,155
JBrowse link
G Cfd complement factor D (adipsin) multiple interactions EXP [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] CTD PMID:2307116 NCBI chr10:79,890,853...79,892,655
Ensembl chr10:79,890,853...79,892,655
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation
ISO
EXP
Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein]
Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
Caffeine results in decreased expression of CHEK1 protein modified form
Caffeine results in decreased phosphorylation of CHEK1 protein
CTD PMID:15975956, PMID:18158334, PMID:19261750, PMID:21505179, PMID:21561856, PMID:22403396, PMID:29074359 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
decreases activity
ISO Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]; Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
Caffeine results in decreased activity of CHEK2 protein
CTD PMID:10531013, PMID:15975956, PMID:16777994, PMID:18158334, PMID:19038232, PMID:23274516 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1, ubiquitous multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CKMT1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 2:121,357,773...121,363,737
Ensembl chr 2:121,357,714...121,363,737
JBrowse link
G Clic1 chloride intracellular channel 1 increases expression ISO Caffeine results in increased expression of CLIC1 protein CTD PMID:31195006 NCBI chr17:35,050,243...35,058,719
Ensembl chr17:35,049,966...35,058,749
JBrowse link
G Clstn1 calsyntenin 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 4:149,585,111...149,648,899
Ensembl chr 4:149,586,468...149,648,899
JBrowse link
G Cnn2 calponin 2 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr10:79,988,600...79,995,400
Ensembl chr10:79,988,584...79,996,062
JBrowse link
G Cobl cordon-bleu WH2 repeat affects expression ISO Caffeine affects the expression of COBL mRNA CTD PMID:20864626 NCBI chr11:12,236,676...12,465,022
Ensembl chr11:12,236,608...12,464,960
JBrowse link
G Coch cochlin decreases expression ISO Caffeine results in decreased expression of COCH mRNA CTD PMID:20864626 NCBI chr12:51,593,283...51,606,619
Ensembl chr12:51,593,341...51,605,771
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
decreases expression
EXP
ISO
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]
Caffeine results in decreased expression of COL1A1 mRNA
CTD PMID:20230807, PMID:24275088 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO Caffeine results in decreased expression of COL2A1 mRNA; Caffeine results in decreased expression of COL2A1 protein CTD PMID:29966748, PMID:32663519 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions EXP [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Coq8a coenzyme Q8A multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COQ8A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COQ8A mRNA] CTD PMID:20230807 NCBI chr 1:180,165,238...180,196,020
Ensembl chr 1:180,165,238...180,199,602
JBrowse link
G Cort cortistatin decreases expression ISO Caffeine results in decreased expression of CORT protein CTD PMID:25868845 NCBI chr 4:149,125,034...149,126,763
Ensembl chr 4:149,125,034...149,126,763
JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7A2L mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr17:83,501,917...83,514,333
Ensembl chr17:83,501,918...83,517,330
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr13:86,044,798...86,046,795
Ensembl chr13:86,044,816...86,046,904
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver decreases expression ISO Caffeine results in decreased expression of CPT1A mRNA CTD PMID:30776459 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO Caffeine results in decreased expression of CREB1 mRNA CTD PMID:26367767 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 decreases expression ISO Caffeine results in decreased expression of CRTC2 protein CTD PMID:31195006 NCBI chr 3:90,253,858...90,264,125
Ensembl chr 3:90,254,163...90,264,125
JBrowse link
G Csnk2a2 casein kinase 2, alpha prime polypeptide decreases expression ISO Caffeine results in decreased expression of CSNK2A2 mRNA CTD PMID:20864626 NCBI chr 8:95,446,096...95,488,868
Ensembl chr 8:95,446,096...95,490,039
JBrowse link
G Cst3 cystatin C multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CST3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 2:148,871,722...148,875,512
Ensembl chr 2:148,871,722...148,875,692
JBrowse link
G Cth cystathionase (cystathionine gamma-lyase) multiple interactions ISO [Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA CTD PMID:29447158 NCBI chr 3:157,894,248...157,925,081
Ensembl chr 3:157,894,248...157,925,077
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 increases mutagenesis
multiple interactions
ISO Caffeine results in increased mutagenesis of CTNNB1 gene
Caffeine inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]
CTD PMID:18283038, PMID:30377735 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Ctsb cathepsin B multiple interactions ISO
EXP
[Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA]
CTD PMID:19490937, PMID:20230807 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Ctsd cathepsin D increases expression ISO Caffeine results in increased expression of CTSD protein CTD PMID:31195006 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Ctsl cathepsin L multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Cwc25 CWC25 spliceosome-associated protein decreases expression ISO Caffeine results in decreased expression of CWC25 protein CTD PMID:31195006 NCBI chr11:97,745,470...97,766,613
Ensembl chr11:97,745,481...97,766,556
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression ISO Caffeine results in increased expression of CXCL8 mRNA CTD PMID:28089782 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyc1 cytochrome c-1 decreases expression ISO Caffeine results in decreased expression of CYC1 mRNA CTD PMID:11793227 NCBI chr15:76,343,513...76,346,260
Ensembl chr15:76,343,523...76,346,260
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Caffeine results in decreased expression of CYP11A1 mRNA CTD PMID:24717552, PMID:25868845 NCBI chr 9:57,998,024...58,027,031
Ensembl chr 9:58,006,411...58,027,023
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 decreases expression ISO Caffeine results in decreased expression of CYP11B2 mRNA CTD PMID:25868845, PMID:29343424 NCBI chr15:74,834,892...74,841,643
Ensembl chr15:74,834,125...74,841,643
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO Caffeine results in increased expression of CYP17A1 mRNA CTD PMID:25868845 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Caffeine results in increased expression of CYP19A1 mRNA; Caffeine results in increased expression of CYP19A1 protein CTD PMID:28111094 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP Caffeine results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding
multiple interactions
increases metabolic processing
decreases activity
affects metabolic processing
increases activity
decreases methylation
ISO
EXP
CYP1A2 protein binds to Caffeine
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]; CYP1A2 protein binds to and affects the metabolism of Caffeine; CYP1A2 protein binds to and results in increased metabolism of Caffeine; GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; Resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]
Caffeine results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of Caffeine; CYP1A2 protein affects the metabolism of Caffeine metabolite
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein binds to and affects the metabolism of Caffeine
Caffeine results in increased activity of CYP1A2 protein
CTD PMID:1302044, PMID:9334905, PMID:11145498, PMID:11376689, PMID:11465391, PMID:11907490, PMID:12433797, PMID:12706856, PMID:14586384, PMID:14586387, PMID:15022032, PMID:15199075, PMID:15286053, PMID:15327588, PMID:15619608, PMID:15659567, PMID:15822860, PMID:15856409, PMID:15980104, PMID:16934051, PMID:18420780, PMID:19215233, PMID:20716633, PMID:24211539, PMID:26599973, PMID:28843594, PMID:31132250 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity EXP Caffeine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases expression
decreases expression
ISO Caffeine results in increased expression of CYP21A1 mRNA
Caffeine results in decreased expression of CYP21A1 mRNA
CTD PMID:25868845, PMID:30528684 NCBI chr17:34,801,348...34,804,426
Ensembl chr17:34,801,348...34,804,561
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity
multiple interactions
increases metabolic processing
EXP
ISO
Caffeine results in decreased activity of CYP2A4 protein
CYP2A6 protein affects the metabolism of and results in increased activity of Caffeine metabolite
CYP2A6 protein results in increased metabolism of Caffeine
CTD PMID:12505289, PMID:17916905, PMID:18420780 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity EXP Caffeine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of Caffeine CTD PMID:1302044, PMID:14586387 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity EXP
ISO
Caffeine results in decreased activity of CYP3A4 protein CTD PMID:18420780, PMID:24211539 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression ISO Caffeine results in increased expression of CYP4B1 mRNA CTD PMID:18444173 NCBI chr 4:115,624,698...115,647,721
Ensembl chr 4:115,624,725...115,647,723
JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 decreases expression ISO Caffeine results in decreased expression of CYP7B1 mRNA CTD PMID:20864626 NCBI chr 3:18,071,944...18,243,890
Ensembl chr 3:18,071,950...18,243,338
JBrowse link
G Dad1 defender against cell death 1 decreases expression ISO Caffeine results in decreased expression of DAD1 mRNA CTD PMID:11793227 NCBI chr14:54,235,485...54,253,929
Ensembl chr14:54,235,479...54,254,104
JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 decreases expression ISO Caffeine results in decreased expression of DCAF11 mRNA CTD PMID:20864626 NCBI chr14:55,559,125...55,570,065
Ensembl chr14:55,560,006...55,570,065
JBrowse link
G Dct dopachrome tautomerase increases expression ISO Caffeine results in increased expression of DCT mRNA CTD PMID:18444173 NCBI chr14:118,012,790...118,052,246
Ensembl chr14:118,012,790...118,052,244
JBrowse link
G Dcxr dicarbonyl L-xylulose reductase multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DCXR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DCXR mRNA] CTD PMID:20230807 NCBI chr11:120,724,546...120,727,284
Ensembl chr11:120,725,399...120,727,281
JBrowse link
G Ddhd1 DDHD domain containing 1 increases expression ISO Caffeine results in increased expression of DDHD1 mRNA CTD PMID:20864626 NCBI chr14:45,593,171...45,658,143
Ensembl chr14:45,588,467...45,658,143
JBrowse link
G Ddx31 DEAD/H box helicase 31 decreases expression ISO Caffeine results in decreased expression of DDX31 mRNA CTD PMID:20864626 NCBI chr 2:28,840,406...28,905,575
Ensembl chr 2:28,840,406...28,905,571
JBrowse link
G Ddx39a DEAD box helicase 39a decreases expression ISO Caffeine results in decreased expression of DDX39A protein CTD PMID:31195006 NCBI chr 8:83,715,177...83,726,904
Ensembl chr 8:83,715,177...83,726,892
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Caffeine results in decreased expression of DHCR24 mRNA CTD PMID:20864626 NCBI chr 4:106,561,038...106,589,113
Ensembl chr 4:106,561,038...106,589,113
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO Caffeine results in decreased expression of DHCR7 mRNA CTD PMID:25868845 NCBI chr 7:143,823,167...143,848,410
Ensembl chr 7:143,823,145...143,848,410
JBrowse link
G Dhodh dihydroorotate dehydrogenase increases expression ISO Caffeine results in increased expression of DHODH protein CTD PMID:6149265 NCBI chr 8:109,593,244...109,608,699
Ensembl chr 8:109,591,343...109,608,673
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 4:40,722,468...40,734,965
Ensembl chr 4:40,722,150...40,737,149
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of DNAJB9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr12:44,205,897...44,210,068
Ensembl chr12:44,205,559...44,210,326
JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression ISO Caffeine results in increased expression of DNAJC12 protein CTD PMID:31195006 NCBI chr10:63,382,443...63,408,840
Ensembl chr10:63,382,443...63,410,576
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 increases expression ISO Caffeine results in increased expression of DNMT1 mRNA CTD PMID:24717552 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3a DNA methyltransferase 3A increases expression ISO Caffeine results in increased expression of DNMT3A mRNA CTD PMID:24717552 NCBI chr12:3,801,559...3,914,443
Ensembl chr12:3,806,007...3,914,443
JBrowse link
G Dnmt3b DNA methyltransferase 3B increases expression ISO Caffeine results in increased expression of DNMT3B mRNA CTD PMID:25868845, PMID:30423288 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 2:62,330,073...62,412,315
Ensembl chr 2:62,330,073...62,412,231
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
increases response to substance
multiple interactions
ISO
EXP
DRD2 polymorphism affects the susceptibility to Caffeine
DRD2 protein results in increased susceptibility to Caffeine
Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]
CTD PMID:11172060, PMID:16889759, PMID:18305461 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Dtx4 deltex 4, E3 ubiquitin ligase decreases expression ISO Caffeine results in decreased expression of DTX4 mRNA CTD PMID:20864626 NCBI chr19:12,466,329...12,502,179
Ensembl chr19:12,466,338...12,501,454
JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Caffeine results in increased expression of DUSP8 mRNA CTD PMID:9813294 NCBI chr 7:142,079,487...142,095,907
Ensembl chr 7:142,079,490...142,095,843
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions EXP Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA] CTD PMID:22403396 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G Ebp phenylalkylamine Ca2+ antagonist (emopamil) binding protein increases expression ISO Caffeine results in increased expression of EBP mRNA CTD PMID:25868845 NCBI chr  X:8,185,329...8,193,512
Ensembl chr  X:8,185,329...8,193,512
JBrowse link
G Ebpl emopamil binding protein-like decreases expression ISO Caffeine results in decreased expression of EBPL mRNA CTD PMID:20864626 NCBI chr14:61,339,763...61,360,445
Ensembl chr14:61,331,742...61,360,439
JBrowse link
G Eci1 enoyl-Coenzyme A delta isomerase 1 decreases expression ISO Caffeine results in decreased expression of ECI1 mRNA CTD PMID:20864626 NCBI chr17:24,426,683...24,439,316
Ensembl chr17:24,426,641...24,439,348
JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ECM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 3:95,734,147...95,739,876
Ensembl chr 3:95,734,147...95,739,569
JBrowse link
G Edn1 endothelin 1 increases activity ISO Caffeine results in increased activity of EDN1 protein CTD PMID:1860718 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions
increases expression
EXP
ISO
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF1A1 mRNA]
Caffeine results in increased expression of EEF1A1 protein
CTD PMID:20230807, PMID:31195006 NCBI chr 9:78,478,453...78,481,724
Ensembl chr 9:78,478,449...78,489,151
JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) decreases expression ISO Caffeine results in decreased expression of EEF1D protein CTD PMID:31195006 NCBI chr15:75,894,796...75,909,784
Ensembl chr15:75,894,205...75,909,556
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma increases expression ISO Caffeine results in increased expression of EEF1G protein CTD PMID:31195006 NCBI chr19:8,967,041...8,978,180
Ensembl chr19:8,967,041...8,978,479
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA] CTD PMID:20230807 NCBI chr10:81,176,631...81,182,509
Ensembl chr10:81,176,631...81,182,498
JBrowse link
G Efna1 ephrin A1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA] CTD PMID:20230807 NCBI chr 3:89,271,730...89,280,951
Ensembl chr 3:89,271,733...89,281,142
JBrowse link
G Efnb3 ephrin B3 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNB3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr11:69,554,092...69,561,150
Ensembl chr11:69,554,092...69,560,205
JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of EGR1 mRNA
Caffeine results in decreased expression of EGR1 mRNA
[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]
[Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNA
CTD PMID:10971643, PMID:16771831 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO Caffeine results in increased expression of EHBP1 protein CTD PMID:31195006 NCBI chr11:22,005,825...22,287,083
Ensembl chr11:22,005,828...22,342,292
JBrowse link
G Ehd1 EH-domain containing 1 decreases expression ISO Caffeine results in decreased expression of EHD1 protein CTD PMID:31195006 NCBI chr19:6,276,896...6,300,096
Ensembl chr19:6,276,725...6,300,096
JBrowse link
G Ehd2 EH-domain containing 2 decreases expression ISO Caffeine results in decreased expression of EHD2 protein CTD PMID:31195006 NCBI chr 7:15,946,963...15,967,535
Ensembl chr 7:15,946,958...15,967,567
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Caffeine results in increased expression of EIF1 mRNA CTD PMID:11793227 NCBI chr11:100,319,949...100,322,099
Ensembl chr11:100,319,885...100,322,096
JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B decreases expression ISO Caffeine results in decreased expression of EIF3B protein CTD PMID:31195006 NCBI chr 5:140,419,305...140,443,358
Ensembl chr 5:140,419,328...140,443,360
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA] CTD PMID:20230807 NCBI chr 3:138,526,191...138,559,696
Ensembl chr 3:138,526,179...138,559,696
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
increases expression
ISO Caffeine results in decreased expression of EIF4EBP1 protein modified form
Caffeine results in increased expression of EIF4EBP1 protein
CTD PMID:21081844 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EIF5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr12:111,538,101...111,546,753
Ensembl chr12:111,538,016...111,546,752
JBrowse link
G Ell elongation factor RNA polymerase II decreases expression ISO Caffeine results in decreased expression of ELL mRNA CTD PMID:20864626 NCBI chr 8:70,539,675...70,592,858
Ensembl chr 8:70,539,457...70,592,858
JBrowse link
G Emc6 ER membrane protein complex subunit 6 decreases expression ISO Caffeine results in decreased expression of EMC6 mRNA CTD PMID:20864626 NCBI chr11:73,175,503...73,177,042
Ensembl chr11:73,175,519...73,177,037
JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression ISO Caffeine results in decreased expression of ENDOD1 mRNA CTD PMID:20864626 NCBI chr 9:14,353,990...14,381,242
Ensembl chr 9:14,353,990...14,381,507
JBrowse link
G Eno1 enolase 1, alpha non-neuron multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Eppk1 epiplakin 1 decreases expression ISO Caffeine results in decreased expression of EPPK1 protein CTD PMID:31195006 NCBI chr15:76,101,488...76,120,195
Ensembl chr15:76,101,481...76,120,195
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERP44 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 4:48,190,711...48,279,635
Ensembl chr 4:48,193,323...48,279,558
JBrowse link
G Esyt2 extended synaptotagmin-like protein 2 decreases expression ISO Caffeine results in decreased expression of ESYT2 mRNA CTD PMID:20864626 NCBI chr12:116,279,283...116,390,935
Ensembl chr12:116,281,196...116,391,050
JBrowse link
G Etv3 ets variant 3 increases expression ISO Caffeine results in increased expression of ETV3 protein CTD PMID:31195006 NCBI chr 3:87,525,577...87,540,158
Ensembl chr 3:87,525,407...87,540,156
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Caffeine results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 1:14,168,953...14,311,035
Ensembl chr 1:14,168,954...14,310,235
JBrowse link
G Ezr ezrin multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA] CTD PMID:20230807 NCBI chr17:6,738,131...6,782,780
Ensembl chr17:6,738,041...6,782,784
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression EXP
ISO
Caffeine results in decreased expression of FABP4 mRNA CTD PMID:23727198 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Farsa phenylalanyl-tRNA synthetase, alpha subunit increases expression ISO Caffeine results in increased expression of FARSA protein CTD PMID:31195006 NCBI chr 8:84,856,969...84,869,257
Ensembl chr 8:84,856,989...84,869,257
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) decreases expression ISO Caffeine results in decreased expression of FAS mRNA CTD PMID:29343424 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression
EXP
ISO
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA
Caffeine results in increased expression of FASN mRNA; Caffeine results in increased expression of FASN protein
CTD PMID:28843594, PMID:30776459 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fastkd3 FAST kinase domains 3 decreases expression ISO Caffeine results in decreased expression of FASTKD3 mRNA CTD PMID:20864626 NCBI chr13:68,582,167...68,592,338
Ensembl chr13:68,582,234...68,592,338
JBrowse link
G Fau Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived) increases expression ISO Caffeine results in increased expression of FAU protein CTD PMID:31195006 NCBI chr19:6,057,947...6,059,524
Ensembl chr19:6,057,844...6,059,524
JBrowse link
G Fbln2 fibulin 2 increases expression ISO Caffeine results in increased expression of FBLN2 mRNA CTD PMID:20864626 NCBI chr 6:91,212,460...91,272,540
Ensembl chr 6:91,212,455...91,272,540
JBrowse link
G Fbrs fibrosin increases expression ISO Caffeine results in increased expression of FBRS mRNA CTD PMID:20864626 NCBI chr 7:127,478,415...127,491,513
Ensembl chr 7:127,479,199...127,491,711
JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of FBXL12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 9:20,637,749...20,644,768
Ensembl chr 9:20,618,118...20,644,767
JBrowse link
G Fbxl19 F-box and leucine-rich repeat protein 19 decreases expression ISO Caffeine results in decreased expression of FBXL19 protein CTD PMID:31195006 NCBI chr 7:127,743,887...127,769,483
Ensembl chr 7:127,744,543...127,769,483
JBrowse link
G Fcsk fucose kinase increases expression ISO Caffeine results in increased expression of FCSK mRNA CTD PMID:20864626 NCBI chr 8:110,882,456...110,902,488
Ensembl chr 8:110,882,456...110,902,488
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression
increases expression
ISO Caffeine results in decreased expression of FDFT1 mRNA
Caffeine results in increased expression of FDFT1 mRNA
CTD PMID:20864626, PMID:25868845 NCBI chr14:63,145,150...63,181,687
Ensembl chr14:63,145,150...63,179,578
JBrowse link
G Fdx1 ferredoxin 1 decreases expression ISO Caffeine results in decreased expression of FDX1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr 9:51,943,023...51,963,602
Ensembl chr 9:51,943,306...51,963,556
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression ISO Caffeine results in increased expression of FHL1 mRNA CTD PMID:20864626 NCBI chr  X:56,731,209...56,793,346
Ensembl chr  X:56,731,787...56,793,346
JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO Caffeine results in increased expression of FILIP1L mRNA CTD PMID:20864626 NCBI chr16:57,353,277...57,572,804
Ensembl chr16:57,353,093...57,573,126
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression
multiple interactions
EXP Caffeine results in increased expression of FOS mRNA
[Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA]
CTD PMID:10971643 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fyn Fyn proto-oncogene multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA] CTD PMID:20230807 NCBI chr10:39,369,743...39,565,381
Ensembl chr10:39,368,855...39,565,381
JBrowse link
G Gale galactose-4-epimerase, UDP multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GALE mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GALE mRNA] CTD PMID:20230807 NCBI chr 4:135,963,681...135,968,178
Ensembl chr 4:135,963,727...135,968,178
JBrowse link
G Ganab alpha glucosidase 2 alpha neutral subunit decreases expression ISO Caffeine results in decreased expression of GANAB protein CTD PMID:31195006 NCBI chr19:8,898,057...8,916,742
Ensembl chr19:8,898,071...8,916,672
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gast gastrin increases secretion ISO Caffeine results in increased secretion of GAST protein CTD PMID:19208342 NCBI chr11:100,334,407...100,336,997
Ensembl chr11:100,334,407...100,336,996
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gdf10 growth differentiation factor 10 decreases expression ISO Caffeine results in decreased expression of GDF10 mRNA CTD PMID:20864626 NCBI chr14:33,923,587...33,936,514
Ensembl chr14:33,923,587...33,937,983
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP
ISO
Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFAP protein]
Caffeine inhibits the reaction [aluminum chloride results in increased expression of GFAP protein]
CTD PMID:19882200, PMID:26339337 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gh growth hormone multiple interactions ISO GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine] CTD PMID:11907490 NCBI chr11:106,300,261...106,303,703
Ensembl chr11:106,300,271...106,301,865
JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GHITM mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr14:37,120,444...37,135,322
Ensembl chr14:37,120,092...37,135,272
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Caffeine results in decreased expression of GJA1 mRNA CTD PMID:28087314 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Glrx glutaredoxin decreases expression ISO Caffeine results in decreased expression of GLRX mRNA CTD PMID:11793227 NCBI chr13:75,839,885...75,850,151
Ensembl chr13:75,839,868...75,850,154
JBrowse link
G Glt8d1 glycosyltransferase 8 domain containing 1 decreases expression ISO Caffeine results in decreased expression of GLT8D1 mRNA CTD PMID:11793227 NCBI chr14:31,001,197...31,012,441
Ensembl chr14:31,001,400...31,011,991
JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO Caffeine results in decreased expression of GLUD1 mRNA CTD PMID:11793227 NCBI chr14:34,310,727...34,345,033
Ensembl chr14:34,310,727...34,345,265
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr14:46,808,149...46,822,259
Ensembl chr14:46,808,149...46,822,242
JBrowse link
G Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 decreases expression
increases expression
ISO Caffeine results in decreased expression of GNAI1 protein
Caffeine results in increased expression of GNAI1 mRNA
CTD PMID:15708489 NCBI chr 5:18,265,135...18,360,413
Ensembl chr 5:18,265,135...18,360,355
JBrowse link
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 decreases expression ISO Caffeine results in decreased expression of GNAI2 protein CTD PMID:15708489 NCBI chr 9:107,614,125...107,635,391
Ensembl chr 9:107,614,125...107,635,367
JBrowse link
G Gnal guanine nucleotide binding protein, alpha stimulating, olfactory type increases response to substance EXP GNAL protein results in increased susceptibility to Caffeine CTD PMID:11404425 NCBI chr18:67,088,298...67,226,792
Ensembl chr18:67,088,216...67,226,792
JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide decreases expression ISO Caffeine results in decreased expression of GNAQ protein CTD PMID:15998294 NCBI chr19:16,132,684...16,388,520
Ensembl chr19:16,132,831...16,387,463
JBrowse link
G Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus decreases expression ISO Caffeine results in decreased expression of GNAS protein CTD PMID:15708489 NCBI chr 2:174,284,320...174,346,744
Ensembl chr 2:174,284,320...174,346,744
JBrowse link
G Golt1b golgi transport 1B multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 6:142,387,211...142,413,835
Ensembl chr 6:142,387,221...142,403,858
JBrowse link
G Gosr1 golgi SNAP receptor complex member 1 decreases expression ISO Caffeine results in decreased expression of GOSR1 mRNA CTD PMID:20864626 NCBI chr11:76,726,602...76,763,578
Ensembl chr11:76,726,602...76,763,579
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial decreases expression ISO Caffeine results in decreased expression of GOT2 protein CTD PMID:31195006 NCBI chr 8:95,864,133...95,888,401
Ensembl chr 8:95,864,134...95,888,547
JBrowse link
G Gpc3 glypican 3 affects expression ISO Caffeine affects the expression of GPC3 mRNA CTD PMID:20864626 NCBI chr  X:52,272,426...52,613,974
Ensembl chr  X:52,272,426...52,613,950
JBrowse link
G Gpi1 glucose-6-phosphate isomerase 1 decreases expression ISO Caffeine results in decreased expression of GPI protein CTD PMID:31195006 NCBI chr 7:34,201,327...34,230,336
Ensembl chr 7:34,201,330...34,230,336
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions
increases activity
ISO Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]; fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Caffeine results in increased activity of GPT protein
CTD PMID:11394713, PMID:30776459 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Caffeine promotes the reaction [bisphenol A results in decreased expression of GPX1 mRNA] CTD PMID:31756439 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP [Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA CTD PMID:31756439 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439
JBrowse link
G Grid2 glutamate receptor, ionotropic, delta 2 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 6:63,256,006...64,704,321
Ensembl chr 6:63,255,876...64,704,323
JBrowse link
G Grm1 glutamate receptor, metabotropic 1 decreases expression ISO Caffeine results in decreased expression of GRM1 protein CTD PMID:15998294 NCBI chr10:10,686,059...11,082,382
Ensembl chr10:10,686,059...11,082,356
JBrowse link
G Grpr gastrin releasing peptide receptor decreases expression ISO Caffeine results in decreased expression of GRPR mRNA CTD PMID:20864626 NCBI chr  X:163,513,904...163,549,736
Ensembl chr  X:163,513,904...163,549,677
JBrowse link
G Grwd1 glutamate-rich WD repeat containing 1 decreases expression ISO Caffeine results in decreased expression of GRWD1 mRNA CTD PMID:20864626 NCBI chr 7:45,825,223...45,830,994
Ensembl chr 7:45,825,223...45,830,944
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression ISO Caffeine results in increased expression of GSK3A mRNA CTD PMID:25868845 NCBI chr 7:25,228,258...25,237,851
Ensembl chr 7:25,228,258...25,237,851
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
decreases phosphorylation
multiple interactions
ISO
EXP
Caffeine results in increased phosphorylation of GSK3B protein
Caffeine results in decreased phosphorylation of GSK3B protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein]
CTD PMID:15126379, PMID:21229324 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gsr glutathione reductase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gstm6 glutathione S-transferase, mu 6 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GSTM6 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTM6 mRNA] CTD PMID:20230807 NCBI chr 3:107,938,847...107,953,641
Ensembl chr 3:107,938,847...107,943,749
JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases expression ISO Caffeine results in decreased expression of GSTO1 mRNA CTD PMID:11793227 NCBI chr19:47,854,973...47,864,790
Ensembl chr19:47,854,970...47,864,790
JBrowse link
G H1f0 H1.0 linker histone decreases expression ISO Caffeine results in decreased expression of H1F0 protein CTD PMID:31195006 NCBI chr15:79,028,212...79,030,504
Ensembl chr15:79,028,450...79,030,504
JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-4 protein CTD PMID:31195006 NCBI chr13:23,621,777...23,622,558
Ensembl chr13:23,620,629...23,622,558
JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-5 protein CTD PMID:31195006 NCBI chr13:21,779,832...21,780,625
Ensembl chr13:21,779,883...21,780,625
JBrowse link
G H1f6 H1.6 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-6 protein CTD PMID:31195006 NCBI chr13:23,695,811...23,696,545
Ensembl chr13:23,695,814...23,696,725
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein]; Caffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]
[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein
CTD PMID:15537744, PMID:15975956, PMID:16777994, PMID:20888899, PMID:24069304, PMID:26231820 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G H4c9 H4 clustered histone 9 increases expression ISO Caffeine results in increased expression of H4C9 protein CTD PMID:31195006 NCBI chr13:22,040,960...22,041,362
Ensembl chr13:22,040,636...22,041,362
JBrowse link
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 decreases expression ISO Caffeine results in decreased expression of HACD1 mRNA CTD PMID:20864626 NCBI chr 2:14,026,831...14,056,035
Ensembl chr 2:13,850,282...14,056,135
JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr11:32,283,672...32,284,486
Ensembl chr11:32,283,511...32,284,465
JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO Caffeine results in increased expression of HDAC1 mRNA CTD PMID:24717552 NCBI chr 4:129,516,104...129,542,646
Ensembl chr 4:129,516,104...129,542,713
JBrowse link
G Hdac2 histone deacetylase 2 increases expression ISO Caffeine results in increased expression of HDAC2 mRNA CTD PMID:24717552 NCBI chr10:36,974,297...37,001,889
Ensembl chr10:36,974,544...37,001,889
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Caffeine results in increased expression of HDAC7 mRNA; Caffeine results in increased expression of HDAC7 protein CTD PMID:31306741 NCBI chr15:97,792,661...97,844,502
Ensembl chr15:97,792,664...97,844,502
JBrowse link
G Hdlbp high density lipoprotein (HDL) binding protein decreases expression ISO Caffeine results in decreased expression of HDLBP mRNA CTD PMID:25868845 NCBI chr 1:93,405,940...93,478,917
Ensembl chr 1:93,405,940...93,478,815
JBrowse link
G Heca hdc homolog, cell cycle regulator increases expression ISO Caffeine results in increased expression of HECA mRNA CTD PMID:20864626 NCBI chr10:17,899,040...17,948,067
Ensembl chr10:17,868,612...17,948,067
JBrowse link
G Hells helicase, lymphoid specific multiple interactions
increases expression
EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]
Caffeine results in increased expression of HELLS protein
CTD PMID:20025956, PMID:20230807 NCBI chr19:38,930,262...38,970,470
Ensembl chr19:38,930,915...38,971,051
JBrowse link
G Hhipl2 hedgehog interacting protein-like 2 decreases expression ISO Caffeine results in decreased expression of HHIPL2 protein CTD PMID:31195006 NCBI chr 1:183,414,463...183,437,053
Ensembl chr 1:183,418,215...183,436,808
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions EXP [Caffeine co-treated with bisphenol A] results in decreased expression of HIF1A mRNA CTD PMID:31756439 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA] CTD PMID:20230807 NCBI chr11:54,866,383...54,870,506
Ensembl chr11:54,866,383...54,870,501
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Caffeine results in decreased expression of HMGA1 protein CTD PMID:31195006 NCBI chr17:27,556,574...27,563,672
Ensembl chr11:120,762,794...120,764,419
Ensembl chr17:120,762,794...120,764,419
JBrowse link
G Hmga2 high mobility group AT-hook 2 decreases expression ISO Caffeine results in decreased expression of HMGA2 protein CTD PMID:31195006 NCBI chr10:120,361,268...120,476,469
Ensembl chr10:120,361,275...120,476,469
JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO Caffeine results in decreased expression of HMGB1 protein CTD PMID:31195006 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions
increases expression
ISO [Dietary Fats co-treated with Caffeine] results in decreased expression of HMGCR mRNA; Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]
Caffeine results in increased expression of HMGCR mRNA; Caffeine results in increased expression of HMGCR protein
CTD PMID:29800656, PMID:29958987, PMID:30825513 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 decreases expression
increases expression
multiple interactions
ISO Caffeine results in decreased expression of HMGCS1 mRNA
Caffeine results in increased expression of HMGCS1 mRNA
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]
CTD PMID:20864626, PMID:25868845, PMID:30825513 NCBI chr13:119,690,351...119,708,260
Ensembl chr13:119,690,379...119,708,260
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Caffeine results in decreased expression of HNRNPA1 protein CTD PMID:31195006 NCBI chr15:103,239,943...103,246,698
Ensembl chr15:103,240,432...103,246,692
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HNRNPC mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr14:52,073,377...52,104,039
Ensembl chr14:52,073,377...52,104,028
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Caffeine results in decreased expression of HNRNPDL protein CTD PMID:31195006 NCBI chr 5:100,033,577...100,039,936
Ensembl chr 5:100,033,577...100,039,664
JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F decreases expression ISO Caffeine results in decreased expression of HNRNPF protein CTD PMID:31195006 NCBI chr 6:117,900,340...117,925,622
Ensembl chr 6:117,900,324...117,925,622
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Caffeine results in decreased expression of HNRNPH1 protein CTD PMID:31195006 NCBI chr11:50,375,257...50,386,528
Ensembl chr11:50,376,990...50,386,528
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression
ISO Caffeine results in decreased expression of HNRNPK mRNA
Caffeine results in increased expression of HNRNPK protein
CTD PMID:25868845, PMID:31195006 NCBI chr13:58,391,132...58,403,343
Ensembl chr13:58,391,142...58,403,343
JBrowse link
G Homer1 homer scaffolding protein 1 multiple interactions ISO HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr13:93,303,757...93,405,129
Ensembl chr13:93,299,635...93,405,129
JBrowse link
G Hoxb7 homeobox B7 increases expression ISO Caffeine results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr11:96,285,604...96,290,163
Ensembl chr11:96,286,623...96,290,162
JBrowse link
G Hprt hypoxanthine guanine phosphoribosyl transferase increases expression ISO Caffeine results in increased expression of HPRT1 protein CTD PMID:6149265 NCBI chr  X:52,988,078...53,021,660
Ensembl chr  X:52,988,137...53,021,659
JBrowse link
G Hras Harvey rat sarcoma virus oncogene multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA] CTD PMID:20230807 NCBI chr 7:141,189,934...141,194,019
Ensembl chr 7:141,189,105...141,194,005
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression ISO Caffeine results in increased expression of HSD11B1 mRNA CTD PMID:22583948, PMID:30423288, PMID:30528684 NCBI chr 1:193,221,640...193,264,045
Ensembl chr 1:193,221,634...193,264,075
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
multiple interactions
ISO Caffeine results in decreased expression of HSD11B2 mRNA
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
CTD PMID:22583948, PMID:22701600, PMID:30423288, PMID:30528684 NCBI chr 8:105,518,746...105,523,988
Ensembl chr 8:105,518,755...105,523,988
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression ISO Caffeine results in decreased expression of HSD17B7 mRNA CTD PMID:20864626 NCBI chr 1:169,949,535...169,969,242
Ensembl chr 1:169,949,535...169,969,241
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression
decreases expression
ISO Caffeine results in increased expression of HSD3B1 mRNA
Caffeine results in decreased expression of HSD3B1 mRNA
CTD PMID:25868845, PMID:30528684 NCBI chr 3:98,842,356...98,859,794
Ensembl chr 3:98,852,194...98,859,794
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA] CTD PMID:20230807 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 decreases expression ISO Caffeine results in decreased expression of HSP90B1 mRNA CTD PMID:25868845 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa4 heat shock protein 4 increases expression ISO Caffeine results in increased expression of HSPA4 protein CTD PMID:31195006 NCBI chr11:53,259,814...53,300,479
Ensembl chr11:53,259,814...53,300,457
JBrowse link
G Hspa9 heat shock protein 9 decreases expression ISO Caffeine results in decreased expression of HSPA9 protein CTD PMID:31195006 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspb1 heat shock protein 1 increases expression
decreases expression
ISO Caffeine results in increased expression of HSPB1 mRNA
Caffeine results in decreased expression of HSPB1 protein
CTD PMID:20864626, PMID:31195006 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspb6 heat shock protein, alpha-crystallin-related, B6 increases expression ISO Caffeine results in increased expression of HSPB6 mRNA CTD PMID:20864626 NCBI chr 7:30,552,535...30,555,443
Ensembl chr 7:30,552,178...30,555,443
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) multiple interactions EXP Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Ibsp integrin binding sialoprotein decreases expression ISO Caffeine results in decreased expression of IBSP mRNA CTD PMID:31874197 NCBI chr 5:104,299,287...104,311,472
Ensembl chr 5:104,299,171...104,311,469
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Caffeine results in decreased expression of ICAM1 mRNA CTD PMID:28089782 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Caffeine results in increased expression of ID3 mRNA CTD PMID:20864626 NCBI chr 4:136,143,822...136,145,392
Ensembl chr 4:136,143,497...136,145,755
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase decreases expression ISO Caffeine results in decreased expression of IDI1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr13:8,885,606...8,892,396
Ensembl chr13:8,885,501...8,892,451
JBrowse link
G Igf1 insulin-like growth factor 1 decreases secretion
multiple interactions
affects expression
decreases activity
decreases expression
EXP
ISO
Caffeine results in decreased secretion of IGF1 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of IGF1 mRNA
Caffeine affects the expression of IGF1 protein
Caffeine results in decreased activity of IGF1 protein
Caffeine results in decreased expression of IGF1 mRNA; Caffeine results in decreased expression of IGF1 protein
CTD PMID:1995187, PMID:22583948, PMID:24239806, PMID:29343424, PMID:29966748, PMID:30528684, PMID:31756439 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf1r insulin-like growth factor I receptor decreases expression
affects expression
ISO Caffeine results in decreased expression of IGF1R mRNA; Caffeine results in decreased expression of IGF1R protein
Caffeine affects the expression of IGF1R mRNA
CTD PMID:22583948, PMID:29343424, PMID:29966748, PMID:30528684 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Caffeine results in increased expression of IGFBP1 mRNA CTD PMID:11793227 NCBI chr11:7,197,787...7,202,546
Ensembl chr11:7,197,782...7,202,546
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases expression ISO Caffeine results in increased expression of IKBKB mRNA CTD PMID:20864626 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il10 interleukin 10 increases expression ISO Caffeine results in increased expression of IL10 mRNA CTD PMID:28089782 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il10rb interleukin 10 receptor, beta increases expression ISO Caffeine results in increased expression of IL10RB mRNA CTD PMID:20864626 NCBI chr16:91,406,157...91,425,834
Ensembl chr16:91,406,164...91,425,834
JBrowse link
G Il12a interleukin 12a decreases expression ISO Caffeine results in decreased expression of IL12A mRNA CTD PMID:28089782 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547
JBrowse link
G Il12b interleukin 12b multiple interactions EXP Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] CTD PMID:26852703 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
ISO Caffeine results in decreased expression of IL1B mRNA
Caffeine results in increased expression of IL1B mRNA
CTD PMID:28089782, PMID:29055810, PMID:30776459 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression EXP Caffeine results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 1:40,404,864...40,465,418
Ensembl chr 1:40,429,570...40,465,415
JBrowse link
G Il3 interleukin 3 multiple interactions EXP Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA] CTD PMID:26852703 NCBI chr11:54,265,085...54,267,279
Ensembl chr11:54,265,303...54,267,277
JBrowse link
G Il4ra interleukin 4 receptor, alpha increases expression
multiple interactions
ISO
EXP
Caffeine results in increased expression of IL4RA mRNA
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IL4RA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA]
CTD PMID:20230807, PMID:20864626 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Il5 interleukin 5 increases expression ISO Caffeine results in increased expression of IL5 mRNA CTD PMID:28089782 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions
ISO
EXP
Caffeine results in decreased expression of IL6 mRNA
Caffeine results in increased expression of IL6 mRNA
Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
CTD PMID:23727198, PMID:26852703, PMID:29055810, PMID:30776459 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ilf3 interleukin enhancer binding factor 3 increases expression ISO Caffeine results in increased expression of ILF3 protein CTD PMID:31195006 NCBI chr 9:21,367,731...21,405,363
Ensembl chr 9:21,367,871...21,405,361
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression ISO Caffeine results in decreased expression of IMPDH2 protein CTD PMID:31195006 NCBI chr 9:108,560,436...108,565,577
Ensembl chr 9:108,560,286...108,565,584
JBrowse link
G Ino80c INO80 complex subunit C decreases expression ISO Caffeine results in decreased expression of INO80C mRNA CTD PMID:20864626 NCBI chr18:24,104,761...24,121,819
Ensembl chr18:24,104,757...24,121,953
JBrowse link
G Ins1 insulin I decreases secretion EXP Caffeine results in decreased secretion of INS1 protein CTD PMID:1995187 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Ins2 insulin II multiple interactions ISO Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:21081844 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO Caffeine results in decreased expression of INSIG1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr 5:28,071,412...28,078,662
Ensembl chr 5:28,071,363...28,078,662
JBrowse link
G Insr insulin receptor decreases expression ISO Caffeine results in decreased expression of INSR mRNA CTD PMID:22583948 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:74,013,914...74,023,921
Ensembl chr  X:74,013,914...74,023,918
JBrowse link
G Irx3 Iroquois related homeobox 3 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr 8:91,798,511...91,801,654
Ensembl chr 8:91,798,525...91,802,067
JBrowse link
G Itgam integrin alpha M multiple interactions EXP Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITGAM protein] CTD PMID:19882200 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Itm2b integral membrane protein 2B multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr14:73,362,226...73,385,289
Ensembl chr14:73,362,226...73,385,289
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 decreases expression ISO Caffeine results in decreased expression of ITPR1 mRNA CTD PMID:18444173 NCBI chr 6:108,213,083...108,551,116
Ensembl chr 6:108,213,096...108,551,109
JBrowse link
G Jun jun proto-oncogene decreases phosphorylation
increases expression
EXP Caffeine results in decreased phosphorylation of JUN protein
Caffeine results in increased expression of JUN protein
CTD PMID:17145898, PMID:20025956 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kctd14 potassium channel tetramerisation domain containing 14 decreases expression ISO Caffeine results in decreased expression of KCTD14 mRNA CTD PMID:20864626 NCBI chr 7:97,436,380...97,459,557
Ensembl chr 7:97,451,323...97,459,557
JBrowse link
G Khsrp KH-type splicing regulatory protein increases expression ISO Caffeine results in increased expression of KHSRP protein CTD PMID:31195006 NCBI chr17:57,021,049...57,031,507
Ensembl chr17:57,021,051...57,031,522
JBrowse link
G Kidins220 kinase D-interacting substrate 220 increases expression ISO Caffeine results in increased expression of KIDINS220 mRNA CTD PMID:20864626 NCBI chr12:24,974,903...25,063,152
Ensembl chr12:24,974,925...25,063,152
JBrowse link
G Kif3b kinesin family member 3B multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KIF3B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 2:153,291,395...153,333,390
Ensembl chr 2:153,291,413...153,333,390
JBrowse link
G Klf4 Kruppel-like factor 4 (gut) multiple interactions
decreases expression
EXP
ISO
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Caffeine results in decreased expression of KLF4 mRNA; Caffeine results in decreased expression of KLF4 protein
CTD PMID:20230807, PMID:31306741 NCBI chr 4:55,527,137...55,532,475
Ensembl chr 4:55,527,143...55,532,466
JBrowse link
G Krt1 keratin 1 decreases expression ISO Caffeine results in decreased expression of KRT1 protein CTD PMID:31195006 NCBI chr15:101,845,426...101,850,786
Ensembl chr15:101,845,426...101,850,794
JBrowse link
G Krt18 keratin 18 decreases expression ISO Caffeine results in decreased expression of KRT18 protein CTD PMID:31195006 NCBI chr15:102,028,216...102,032,026
Ensembl chr15:102,028,180...102,032,027
JBrowse link
G Krt36 keratin 36 decreases expression ISO Caffeine results in decreased expression of KRT36 protein CTD PMID:31195006 NCBI chr11:100,102,012...100,109,487
Ensembl chr11:100,102,007...100,105,626
JBrowse link
G Krt84 keratin 84 decreases expression ISO Caffeine results in decreased expression of KRT84 protein CTD PMID:31195006 NCBI chr15:101,525,026...101,532,820
Ensembl chr15:101,525,026...101,532,820
JBrowse link
G Lamb1 laminin B1 increases expression ISO Caffeine results in increased expression of LAMB1 protein CTD PMID:31195006 NCBI chr12:31,265,146...31,329,644
Ensembl chr12:31,265,234...31,329,644
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Caffeine results in decreased expression of LDHA mRNA CTD PMID:11793227 NCBI chr 7:46,842,274...46,855,627
Ensembl chr 7:46,841,475...46,855,627
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO [Caffeine co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; Caffeine promotes the reaction [Dietary Fats results in decreased expression of LDLR mRNA] CTD PMID:29800656 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919
JBrowse link
G Lep leptin decreases expression
multiple interactions
EXP
ISO
Caffeine results in decreased expression of LEP mRNA
Caffeine results in decreased expression of LEP mRNA; Caffeine results in decreased expression of LEP protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]
CTD PMID:23727198, PMID:26367767 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor increases expression
decreases expression
ISO Caffeine results in increased expression of LEPR mRNA
Caffeine results in decreased expression of LEPR mRNA
CTD PMID:22583948, PMID:26367767 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Caffeine results in decreased expression of LMNB1 protein CTD PMID:31195006 NCBI chr18:56,707,813...56,753,424
Ensembl chr18:56,707,813...56,753,424
JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:106,920,625...106,933,899
Ensembl chr  X:106,920,625...106,933,900
JBrowse link
G Lpl lipoprotein lipase decreases expression
multiple interactions
ISO
EXP
Caffeine results in decreased expression of LPL mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA
CTD PMID:23727198, PMID:28843594 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Lss lanosterol synthase multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr10:76,531,565...76,557,139
Ensembl chr10:76,531,588...76,557,138
JBrowse link
G Lysmd2 LysM, putative peptidoglycan-binding, domain containing 2 decreases expression ISO Caffeine results in decreased expression of LYSMD2 mRNA CTD PMID:20864626 NCBI chr 9:75,625,121...75,637,773
Ensembl chr 9:75,625,741...75,637,771
JBrowse link
G Mael maelstrom spermatogenic transposon silencer decreases expression ISO Caffeine results in decreased expression of MAEL protein CTD PMID:31195006 NCBI chr 1:166,201,385...166,238,744
Ensembl chr 1:166,201,201...166,238,747
JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:16,619,698...16,687,812
Ensembl chr  X:16,619,698...16,687,818
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases cleavage
multiple interactions
ISO
EXP
Caffeine results in increased cleavage of MAP1LC3B protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
CTD PMID:30555576 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAP2K7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr 8:4,238,740...4,247,897
Ensembl chr 8:4,238,740...4,247,897
Ensembl chr 8:4,238,740...4,247,897
JBrowse link
G Map3k12 mitogen-activated protein kinase kinase kinase 12 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP3K12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP3K12 mRNA] CTD PMID:20230807 NCBI chr15:102,497,647...102,517,004
Ensembl chr15:102,497,646...102,517,064
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases expression
multiple interactions
decreases phosphorylation
ISO
EXP
Caffeine results in increased expression of MAPK1 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Caffeine results in decreased phosphorylation of MAPK1 protein
CTD PMID:17145898, PMID:21081844, PMID:22974838 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 increases expression ISO Caffeine results in increased expression of MAPK15 mRNA CTD PMID:20864626 NCBI chr15:75,993,732...75,999,153
Ensembl chr15:75,993,769...75,999,154
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases expression
multiple interactions
decreases phosphorylation
ISO
EXP
Caffeine results in increased expression of MAPK3 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Caffeine results in decreased phosphorylation of MAPK3 protein
CTD PMID:17145898, PMID:21081844, PMID:22974838 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Marchf11 membrane associated ring-CH-type finger 11 decreases expression ISO Caffeine results in decreased expression of MARCHF11 mRNA CTD PMID:20864626 NCBI chr15:26,309,048...26,409,586
Ensembl chr15:26,309,048...26,409,576
JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MC2R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MC2R mRNA] CTD PMID:20230807 NCBI chr18:68,406,899...68,429,320
Ensembl chr18:68,406,907...68,429,320
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP Caffeine results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 1:20,802,966...20,820,312
Ensembl chr 1:20,802,968...20,820,312
JBrowse link
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) decreases expression ISO Caffeine results in decreased expression of MDH2 protein CTD PMID:31195006 NCBI chr 5:135,778,649...135,790,386
Ensembl chr 5:135,778,480...135,790,398
JBrowse link
G Mef2a myocyte enhancer factor 2A increases expression
multiple interactions
ISO Caffeine results in increased expression of MEF2A mRNA; Caffeine results in increased expression of MEF2A protein
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]
CTD PMID:25093688 NCBI chr 7:67,231,163...67,376,456
Ensembl chr 7:67,231,163...67,372,858
JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]
Caffeine results in increased expression of MEF2C mRNA; Caffeine results in increased expression of MEF2C protein
CTD PMID:25093688 NCBI chr13:83,504,017...83,667,079
Ensembl chr13:83,504,034...83,667,080
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Caffeine results in decreased expression of MGST1 mRNA CTD PMID:11793227 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link
G Mill2 MHC I like leukocyte 2 multiple interactions ISO Caffeine inhibits the reaction [[decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein] CTD PMID:18395517 NCBI chr 7:18,839,958...18,869,696
Ensembl chr 7:18,839,966...18,865,402
JBrowse link
G Mir101a microRNA 101a multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 4:101,346,945...101,347,027
Ensembl chr 4:101,346,945...101,347,027
JBrowse link
G Mir122 microRNA 122 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:65,248,861...65,248,926
Ensembl chr18:65,248,861...65,248,926
JBrowse link
G Mir192 microRNA 192 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr19:6,264,844...6,264,932
Ensembl chr19:6,264,844...6,264,932
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions
decreases expression
ISO Caffeine inhibits the reaction [aluminum chloride results in decreased expression of MKI67 protein]
Caffeine results in decreased expression of MKI67 protein
CTD PMID:26339337, PMID:30528684 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr 5:135,089,890...135,139,768
Ensembl chr 5:135,089,890...135,138,382
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Caffeine results in increased expression of MMP13 mRNA CTD PMID:31874197 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA] CTD PMID:20230807 NCBI chr 9:7,692,090...7,699,585
Ensembl chr 9:7,692,090...7,699,585
JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 decreases expression ISO Caffeine results in decreased expression of MOGAT1 mRNA CTD PMID:20864626 NCBI chr 1:78,511,060...78,606,964
Ensembl chr 1:78,510,991...78,538,173
JBrowse link
G Mos Moloney sarcoma oncogene increases expression ISO Caffeine results in increased expression of MOS protein CTD PMID:31195006 NCBI chr 4:3,870,658...3,872,105
Ensembl chr 4:3,870,657...3,872,105
JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Caffeine results in decreased expression of MRM3 mRNA CTD PMID:20864626 NCBI chr11:76,243,736...76,250,625
Ensembl chr11:76,243,715...76,250,619
JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 decreases expression ISO Caffeine results in decreased expression of MRPL19 mRNA CTD PMID:20864626 NCBI chr 6:81,957,826...81,965,949
Ensembl chr 6:81,957,851...81,965,958
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 4:155,802,878...155,808,831
Ensembl chr 4:155,802,878...155,809,975
JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 3:94,443,154...94,448,708
Ensembl chr 3:94,443,318...94,451,130
JBrowse link
G Mrps5 mitochondrial ribosomal protein S5 increases expression ISO Caffeine results in increased expression of MRPS5 protein CTD PMID:31195006 NCBI chr 2:127,587,426...127,603,986
Ensembl chr 2:127,587,222...127,606,829
JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Caffeine results in decreased expression of MSH2 mRNA CTD PMID:12706856 NCBI chr17:87,672,532...87,723,713
Ensembl chr17:87,672,330...87,723,713
JBrowse link
G Msmo1 methylsterol monoxygenase 1 decreases expression ISO Caffeine results in decreased expression of MSMO1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr 8:64,718,123...64,733,578
Ensembl chr 8:64,718,139...64,733,792
JBrowse link
G Mt2 metallothionein 2 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTCH1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr17:29,332,076...29,347,947
Ensembl chr17:29,332,072...29,347,934
JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr 5:108,065,660...108,109,219
Ensembl chr 5:108,065,674...108,109,004
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like decreases expression ISO Caffeine results in decreased expression of MTHFD2L mRNA CTD PMID:20864626 NCBI chr 5:90,930,873...91,021,368
Ensembl chr 5:90,931,117...91,021,368
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity ISO Caffeine results in decreased activity of MTOR protein CTD PMID:21081844 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase decreases expression ISO Caffeine results in decreased expression of MTRR mRNA CTD PMID:20864626 NCBI chr13:68,560,780...68,582,169
Ensembl chr13:68,560,780...68,582,149
JBrowse link
G Mutyh mutY DNA glycosylase increases expression ISO Caffeine results in increased expression of MUTYH mRNA CTD PMID:20864626 NCBI chr 4:116,807,636...116,819,439
Ensembl chr 4:116,807,723...116,819,440
JBrowse link
G Mvd mevalonate (diphospho) decarboxylase decreases expression ISO Caffeine results in decreased expression of MVD mRNA CTD PMID:25868845 NCBI chr 8:122,433,596...122,443,422
Ensembl chr 8:122,433,601...122,443,422
JBrowse link
G Mvk mevalonate kinase increases expression ISO Caffeine results in increased expression of MVK mRNA CTD PMID:25868845 NCBI chr 5:114,444,264...114,460,591
Ensembl chr 5:114,444,269...114,460,591
JBrowse link
G Myc myelocytomatosis oncogene multiple interactions ISO Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA] CTD PMID:18283038 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta increases expression
multiple interactions
ISO Caffeine results in increased expression of MYH7 mRNA
Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; Cyclosporine inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]
CTD PMID:25093688 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626
JBrowse link
G Myl6b myosin, light polypeptide 6B decreases expression ISO Caffeine results in decreased expression of MYL6B protein CTD PMID:31195006 NCBI chr10:128,494,157...128,498,685
Ensembl chr10:128,494,157...128,498,685
JBrowse link
G Myof myoferlin increases expression ISO Caffeine results in increased expression of MYOF protein CTD PMID:31195006 NCBI chr19:37,899,036...38,043,577
Ensembl chr19:37,899,036...38,043,577
JBrowse link
G Nat2 N-acetyltransferase 2 (arylamine N-acetyltransferase) increases acetylation
affects metabolic processing
ISO NAT2 protein results in increased acetylation of Caffeine
NAT2 gene polymorphism affects the metabolism of Caffeine; NAT2 protein affects the metabolism of Caffeine
CTD PMID:14586384, PMID:14586387, PMID:14747882, PMID:15199075, PMID:15327588, PMID:15558239, PMID:15980104, PMID:24221535 NCBI chr 8:67,494,875...67,502,644
Ensembl chr 8:67,494,858...67,502,584
JBrowse link
G Ncl nucleolin increases expression ISO Caffeine results in increased expression of NCL protein CTD PMID:31195006 NCBI chr 1:86,344,719...86,359,455
Ensembl chr 1:86,344,719...86,359,400
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NDUFB5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 3:32,737,057...32,751,559
Ensembl chr 3:32,736,990...32,751,566
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase core subunit S4 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFS4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFS4 mRNA] CTD PMID:20230807 NCBI chr13:114,287,795...114,388,094
Ensembl chr13:114,287,795...114,388,258
JBrowse link
G Nefh neurofilament, heavy polypeptide affects expression ISO Caffeine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr11:4,938,754...4,948,064
Ensembl chr11:4,938,754...4,948,064
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Caffeine results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 3:127,632,733...127,635,636
Ensembl chr 3:127,633,135...127,635,631
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:22974838 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] CTD PMID:26852703 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nisch nischarin multiple interactions ISO Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr14:31,170,928...31,206,826
Ensembl chr14:31,170,930...31,216,946
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22974838, PMID:26852703 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions ISO [Isoproterenol co-treated with Caffeine] results in decreased expression of NOS3 mRNA CTD PMID:29447158 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nphs1 nephrosis 1, nephrin decreases expression ISO Caffeine results in decreased expression of NPHS1 mRNA; Caffeine results in decreased expression of NPHS1 protein CTD PMID:25986755, PMID:31306741 NCBI chr 7:30,458,207...30,488,623
Ensembl chr 7:30,458,315...30,487,223
JBrowse link
G Nphs2 nephrosis 2, podocin decreases expression ISO Caffeine results in decreased expression of NPHS2 mRNA CTD PMID:25986755, PMID:31306741 NCBI chr 1:156,310,535...156,328,035
Ensembl chr 1:156,310,727...156,328,035
JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr 1:153,503,016...153,549,714
Ensembl chr 1:153,503,015...153,550,045
JBrowse link
G Nppa natriuretic peptide type A multiple interactions
increases expression
ISO Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] CTD PMID:15452191, PMID:25093688 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Nppb natriuretic peptide type B increases expression
multiple interactions
ISO Caffeine results in increased expression of NPPB mRNA
Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]
CTD PMID:25093688 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Caffeine results in increased expression of NR3C1 mRNA; Caffeine results in increased expression of NR3C1 protein CTD PMID:22583948, PMID:30423288, PMID:30528684, PMID:30776459, PMID:31306741, PMID:32663519 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression ISO Caffeine results in increased expression of NR3C2 mRNA CTD PMID:22959462 NCBI chr 8:76,898,083...77,245,012
Ensembl chr 8:76,899,442...77,245,012
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases methylation
decreases expression
ISO Caffeine results in increased methylation of NR5A1 promoter
Caffeine results in decreased expression of NR5A1 mRNA; Caffeine results in decreased expression of NR5A1 protein
CTD PMID:24717552 NCBI chr 2:38,692,656...38,714,542
Ensembl chr 2:38,692,656...38,714,542
JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression ISO Caffeine results in decreased expression of NRF1 mRNA CTD PMID:20864626 NCBI chr 6:30,047,985...30,153,458
Ensembl chr 6:30,047,988...30,153,458
JBrowse link
G Nsf N-ethylmaleimide sensitive fusion protein multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr11:103,821,782...103,954,056
Ensembl chr11:103,821,782...103,954,056
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions
decreases activity
ISO caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein] CTD PMID:28465162 NCBI chr 9:88,327,609...88,372,089
Ensembl chr 9:88,327,197...88,372,092
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861
JBrowse link
G Oat ornithine aminotransferase increases expression ISO Caffeine results in increased expression of OAT mRNA CTD PMID:11793227 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Caffeine results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr10:19,356,539...19,358,604
Ensembl chr10:19,356,533...19,358,604
JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Caffeine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 4:63,344,556...63,348,163
Ensembl chr 4:63,344,560...63,348,163
JBrowse link
G Orm2 orosomucoid 2 increases expression EXP Caffeine results in increased expression of ORM2 protein CTD PMID:20025956 NCBI chr 4:63,362,449...63,365,877
Ensembl chr 4:63,362,449...63,365,878
JBrowse link
G Oxsr1 oxidative-stress responsive 1 increases expression ISO Caffeine results in increased expression of OXSR1 mRNA CTD PMID:20864626 NCBI chr 9:119,238,432...119,322,684
Ensembl chr 9:119,238,432...119,322,427
JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of P3H3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 6:124,841,089...124,857,746
Ensembl chr 6:124,841,089...124,857,752
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 decreases expression ISO Caffeine results in decreased expression of PAK1 mRNA CTD PMID:29343424 NCBI chr 7:97,788,541...97,912,381
Ensembl chr 7:97,788,541...97,912,381
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 increases activity
multiple interactions
ISO
EXP
Caffeine results in increased activity of PAK2 protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]
CTD PMID:19325779, PMID:20230807 NCBI chr16:32,016,290...32,079,342
Ensembl chr16:32,016,290...32,079,342
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 affects cleavage
decreases response to substance
multiple interactions
increases cleavage
ISO Caffeine affects the cleavage of PARP1 protein
PARP1 protein results in decreased susceptibility to Caffeine
Caffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; Caffeine results in increased cleavage of and results in increased expression of PARP1 protein
Caffeine results in increased cleavage of PARP1 protein
CTD PMID:16522534, PMID:19242509, PMID:19490937, PMID:21229324, PMID:21840268, PMID:22226932, PMID:30377735 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pax3 paired box 3 decreases expression ISO Caffeine results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 1:78,101,267...78,197,136
Ensembl chr 1:78,101,267...78,197,134
JBrowse link
G Pcare photoreceptor cilium actin regulator decreases expression ISO Caffeine results in decreased expression of PCARE protein CTD PMID:31195006 NCBI chr17:71,743,555...71,752,905
Ensembl chr17:71,743,555...71,752,894
JBrowse link
G Pcna proliferating cell nuclear antigen affects expression ISO Caffeine affects the expression of PCNA mRNA; Caffeine affects the expression of PCNA protein CTD PMID:29343424 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO Caffeine results in decreased expression of PCSK9 mRNA CTD PMID:25868845 NCBI chr 4:106,442,334...106,464,325
Ensembl chr 4:106,442,329...106,464,329
JBrowse link
G Pde11a phosphodiesterase 11A decreases expression ISO Caffeine results in decreased expression of PDE11A mRNA CTD PMID:20864626 NCBI chr 2:75,985,808...76,339,145
Ensembl chr 2:75,989,141...76,338,774
JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific decreases expression ISO Caffeine results in decreased expression of PDE5A mRNA CTD PMID:20864626 NCBI chr 3:122,729,158...122,859,374
Ensembl chr 3:122,728,947...122,859,374
JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X decreases expression ISO Caffeine results in decreased expression of PDHX mRNA CTD PMID:20864626 NCBI chr 2:103,021,055...103,073,513
Ensembl chr 2:103,021,075...103,073,513
JBrowse link
G Pdia6 protein disulfide isomerase associated 6 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PDIA6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr12:17,266,589...17,284,785
Ensembl chr12:17,266,545...17,284,770
JBrowse link
G Pfdn1 prefoldin 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:36,403,679...36,454,495
Ensembl chr18:36,403,676...36,454,524
JBrowse link
G Pfkm phosphofructokinase, muscle affects expression ISO Caffeine affects the expression of PFKM protein CTD PMID:25486098 NCBI chr15:98,092,589...98,132,447
Ensembl chr15:98,092,589...98,132,451
JBrowse link
G Pgk2 phosphoglycerate kinase 2 decreases expression ISO Caffeine results in decreased expression of PGK2 protein CTD PMID:31195006 NCBI chr17:40,207,018...40,208,609
Ensembl chr17:40,207,015...40,208,640
JBrowse link
G Pgr progesterone receptor increases expression ISO Caffeine results in increased expression of PGR mRNA CTD PMID:20864626 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Phb prohibitin multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA] CTD PMID:20230807 NCBI chr11:95,666,957...95,680,773
Ensembl chr11:95,666,957...95,680,773
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression EXP Caffeine results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:157,162,075...157,415,286
Ensembl chr  X:157,162,075...157,415,312
JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PHTF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA] CTD PMID:20230807 NCBI chr 3:103,968,110...104,007,490
Ensembl chr 3:103,968,110...104,024,598
JBrowse link
G Pidd1 p53 induced death domain protein 1 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 7:141,438,113...141,447,565
Ensembl chr 7:141,438,113...141,444,025
JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr 1:161,969,188...161,973,460
Ensembl chr 1:161,969,186...161,973,435
JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr10:81,292,835...81,319,974
Ensembl chr10:81,292,963...81,319,973
JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 decreases expression ISO Caffeine results in decreased expression of PITX2 mRNA CTD PMID:20864626 NCBI chr 3:129,199,878...129,219,594
Ensembl chr 3:129,199,878...129,219,591
JBrowse link
G Pkd1 polycystin 1, transient receptor poteintial channel interacting multiple interactions
affects response to substance
EXP PKD1 protein affects the reaction [Caffeine affects the abundance of Calcium]
PKD1 protein affects the susceptibility to Caffeine
CTD PMID:18679710 NCBI chr17:24,548,689...24,596,514
Ensembl chr17:24,549,834...24,596,508
JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions EXP [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 3:129,878,606...129,895,825
Ensembl chr 3:129,878,606...129,895,825
JBrowse link
G Plcb1 phospholipase C, beta 1 multiple interactions
decreases expression
ISO Caffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]
Caffeine results in decreased expression of PLCB1 protein
CTD PMID:15998294 NCBI chr 2:134,786,164...135,475,258
Ensembl chr 2:134,786,067...135,475,258
JBrowse link
G Plec plectin decreases expression ISO Caffeine results in decreased expression of PLEC protein CTD PMID:31195006 NCBI chr15:76,170,974...76,231,378
Ensembl chr15:76,170,974...76,232,574
JBrowse link
G Plg plasminogen decreases expression ISO Caffeine results in decreased expression of PLG mRNA CTD PMID:25868845 NCBI chr17:12,378,609...12,419,384
Ensembl chr17:12,378,608...12,419,385
JBrowse link
G Plp1 proteolipid protein (myelin) 1 increases expression ISO Caffeine results in increased expression of PLP1 mRNA CTD PMID:18444173 NCBI chr  X:136,820,148...136,838,582
Ensembl chr  X:136,822,671...136,839,733
JBrowse link
G Pls1 plastin 1 (I-isoform) increases expression ISO Caffeine results in increased expression of PLS1 protein CTD PMID:31195006 NCBI chr 9:95,752,642...95,845,306
Ensembl chr 9:95,752,642...95,845,311
JBrowse link
G Pls3 plastin 3 (T-isoform) decreases expression ISO Caffeine results in decreased expression of PLS3 protein CTD PMID:31195006 NCBI chr  X:75,785,653...75,875,182
Ensembl chr  X:75,785,654...75,875,182
JBrowse link
G Pnp2 purine-nucleoside phosphorylase 2 increases expression ISO Caffeine results in increased expression of PNP protein CTD PMID:6149265 NCBI chr14:50,956,141...50,964,751
Ensembl chr14:50,955,992...50,964,749
JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr12:44,269,132...44,315,936
Ensembl chr12:44,221,370...44,322,532
JBrowse link
G Pomc pro-opiomelanocortin-alpha increases secretion ISO Caffeine results in increased secretion of POMC protein alternative form CTD PMID:22959462 NCBI chr12:3,954,945...3,960,643
Ensembl chr12:3,954,951...3,960,642
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Caffeine results in decreased expression of PPARA mRNA CTD PMID:30776459 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
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G Pparg peroxisome proliferator activated receptor gamma decreases expression EXP
ISO
Caffeine results in decreased expression of PPARG mRNA CTD PMID:23727198 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
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G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Caffeine results in increased expression of PPARGC1A mRNA CTD PMID:17516843 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
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G Ppfibp1 PTPRF interacting protein, binding protein 1 (liprin beta 1) increases expression ISO Caffeine results in increased expression of PPFIBP1 protein CTD PMID:31195006 NCBI chr 6:146,886,609...147,032,025
Ensembl chr 6:146,888,487...147,032,025
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G Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPM1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr17:84,956,741...85,023,992
Ensembl chr17:84,956,741...85,023,991
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G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression ISO Caffeine results in decreased expression of PPP2R2B mRNA CTD PMID:18444173 NCBI chr18:42,645,207...43,059,471
Ensembl chr18:42,637,432...43,059,471
Ensembl chr18:42,637,432...43,059,471
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G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions EXP [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr12:55,280,809...55,303,239
Ensembl chr12:55,278,991...55,302,998
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G Prdx2 peroxiredoxin 2 increases expression ISO Caffeine results in increased expression of PRDX2 protein CTD PMID:31195006 NCBI chr 8:84,969,622...84,974,811
Ensembl chr 8:84,969,587...84,974,834
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G Prelid1 PRELI domain containing 1 decreases expression ISO Caffeine results in decreased expression of PRELID1 mRNA CTD PMID:11793227 NCBI chr13:55,322,055...55,325,272
Ensembl chr13:55,320,500...55,325,272
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G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation EXP Caffeine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899
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G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit increases expression