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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diuretic
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Accession:CHEBI:35498 term browser browse the term
Definition:An agent that promotes the excretion of urine through its effects on kidney function.
Synonyms:related_synonym: diuretics


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5-(N,N-hexamethylene)amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDIT3 DNA damage inducible transcript 3 increases expression EXP 5-(N,N-hexamethylene)amiloride results in increased expression of DDIT3 mRNA CTD PMID:19302589 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 affects expression EXP 5-(N,N-hexamethylene)amiloride affects the expression of HSP90B1 mRNA CTD PMID:19302589 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,645
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 affects expression EXP 5-(N,N-hexamethylene)amiloride affects the expression of HSPA5 mRNA CTD PMID:19302589 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A increases expression EXP 5-(N,N-hexamethylene)amiloride results in increased expression of PPP1R15A mRNA CTD PMID:19302589 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,421...48,876,058
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP 5-(N,N-hexamethylene)amiloride results in increased expression of PTGS2 mRNA CTD PMID:19302589 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G SERPINB1 serpin family B member 1 multiple interactions EXP 5-(N,N-hexamethylene)amiloride results in increased cleavage of and results in increased activity of and affects the localization of SERPINB1 protein modified form CTD PMID:25447644 NCBI chr 6:2,832,332...2,842,012
Ensembl chr 6:2,832,332...2,841,959
JBrowse link
8-(3-chlorostyryl)caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor multiple interactions
increases response to substance
ISO 8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine
CTD PMID:11172060, PMID:15641640, PMID:18608257, PMID:19966059, PMID:21195062 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G DRD2 dopamine receptor D2 affects response to substance
multiple interactions
ISO DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]
CTD PMID:11172060 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] CTD PMID:8577368, PMID:10199625 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NTS neurotensin multiple interactions ISO 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992
JBrowse link
acetazolamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression ISO Acetazolamide results in increased expression of ABCA1 mRNA CTD PMID:19274763 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G AKAP17A A-kinase anchoring protein 17A increases expression ISO Acetazolamide results in increased expression of AKAP17B mRNA CTD PMID:19274763 NCBI chr  X:1,591,604...1,602,520
NCBI chr  Y:1,591,604...1,602,520
Ensembl chr  X:1,591,604...1,602,520
JBrowse link
G AKAP9 A-kinase anchoring protein 9 increases expression ISO Acetazolamide results in increased expression of AKAP9 mRNA CTD PMID:19274763 NCBI chr 7:91,940,862...92,112,908
Ensembl chr 7:91,940,867...92,110,673
Ensembl chr 7:91,940,867...92,110,673
JBrowse link
G AMMECR1L AMMECR1 like increases expression ISO Acetazolamide results in increased expression of AMMECR1L mRNA CTD PMID:19274763 NCBI chr 2:127,861,630...127,887,575
Ensembl chr 2:127,861,630...127,885,922
Ensembl chr 2:127,861,630...127,885,922
JBrowse link
G ANP32A acidic nuclear phosphoprotein 32 family member A increases expression ISO Acetazolamide results in increased expression of ANP32A mRNA CTD PMID:19274763 NCBI chr15:68,778,535...68,820,895
Ensembl chr15:68,778,535...68,820,897
JBrowse link
G AQP1 aquaporin 1 (Colton blood group) decreases expression EXP Acetazolamide results in decreased expression of AQP1 protein CTD PMID:17219999 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517
Ensembl chr 7:30,911,853...30,925,517
JBrowse link
G ARHGAP45 Rho GTPase activating protein 45 affects expression EXP Acetazolamide affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr19:1,065,959...1,086,628
Ensembl chr19:1,065,923...1,086,628
JBrowse link
G ARID2 AT-rich interaction domain 2 increases expression ISO Acetazolamide results in increased expression of ARID2 mRNA CTD PMID:19274763 NCBI chr12:45,729,706...45,908,037
Ensembl chr12:45,729,706...45,908,040
JBrowse link
G BRD4 bromodomain containing 4 increases expression ISO Acetazolamide results in increased expression of BRD4 mRNA CTD PMID:19274763 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545
JBrowse link
G CA1 carbonic anhydrase 1 multiple interactions
decreases activity
EXP Acetazolamide binds to and results in decreased activity of CA1 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA1 protein] CTD PMID:11430635, PMID:17826101, PMID:19231207, PMID:28117934, PMID:28251759, PMID:29131470, PMID:29283199, PMID:29457667, PMID:29975450, PMID:29992664, PMID:30291660, PMID:30368973, PMID:30431690, PMID:30537031 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA12 carbonic anhydrase 12 decreases activity
multiple interactions
EXP Acetazolamide results in decreased activity of CA12 protein
Acetazolamide binds to and results in decreased activity of CA12 protein
CTD PMID:21851094, PMID:28251759 NCBI chr15:63,321,378...63,381,846
Ensembl chr15:63,321,378...63,381,846
JBrowse link
G CA13 carbonic anhydrase 13 multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA13 protein CTD PMID:28251759 NCBI chr 8:85,245,458...85,284,073
Ensembl chr 8:85,220,587...85,284,073
JBrowse link
G CA14 carbonic anhydrase 14 multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA14 protein CTD PMID:28251759 NCBI chr 1:150,257,258...150,265,862
Ensembl chr 1:150,257,251...150,265,078
JBrowse link
G CA2 carbonic anhydrase 2 multiple interactions
decreases activity
EXP Acetazolamide binds to and results in decreased activity of CA2 protein; Indomethacin inhibits the reaction [Acetazolamide results in decreased activity of CA2 protein] CTD PMID:11430635, PMID:16858005, PMID:17826101, PMID:19231207, PMID:21851094, PMID:28117934, PMID:28251759, PMID:29131470, PMID:29283199, PMID:29457667, PMID:29975450, PMID:29992664, PMID:30291660, PMID:30368973, PMID:30431690, PMID:30537031 NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493
JBrowse link
G CA3 carbonic anhydrase 3 multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CA4 carbonic anhydrase 4 multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA4 protein CTD PMID:28251759 NCBI chr17:60,149,942...60,179,021
Ensembl chr17:60,149,942...60,170,899
JBrowse link
G CA5A carbonic anhydrase 5A multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA5A protein CTD PMID:28251759 NCBI chr16:87,881,549...87,936,575
Ensembl chr16:87,881,546...87,936,580
JBrowse link
G CA5B carbonic anhydrase 5B multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA5B protein CTD PMID:28251759 NCBI chr  X:15,738,270...15,788,411
Ensembl chr  X:15,688,830...15,788,411
JBrowse link
G CA6 carbonic anhydrase 6 multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA6 protein CTD PMID:28251759 NCBI chr 1:8,945,868...8,975,092
Ensembl chr 1:8,945,867...8,975,092
JBrowse link
G CA7 carbonic anhydrase 7 multiple interactions EXP Acetazolamide binds to and results in decreased activity of CA7 protein CTD PMID:28251759 NCBI chr16:66,844,414...66,854,149
Ensembl chr16:66,844,414...66,854,153
JBrowse link
G CA9 carbonic anhydrase 9 decreases activity
multiple interactions
EXP Acetazolamide results in decreased activity of CA9 protein
Acetazolamide binds to and results in decreased activity of CA9 protein
CTD PMID:21851094, PMID:28251759 NCBI chr 9:35,673,809...35,681,159
Ensembl chr 9:35,673,918...35,681,159
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein] CTD PMID:21040473 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CBX3 chromobox 3 increases expression ISO Acetazolamide results in increased expression of CBX3 mRNA CTD PMID:19274763 NCBI chr 7:26,201,443...26,213,607
Ensembl chr 7:26,201,162...26,213,607
JBrowse link
G CCND2 cyclin D2 increases expression ISO Acetazolamide results in increased expression of CCND2 mRNA CTD PMID:19274763 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CD47 CD47 molecule increases expression ISO Acetazolamide results in increased expression of CD47 mRNA CTD PMID:19274763 NCBI chr 3:108,043,091...108,094,200
Ensembl chr 3:108,043,091...108,091,862
JBrowse link
G CIRBP cold inducible RNA binding protein increases expression ISO Acetazolamide results in increased expression of CIRBP mRNA CTD PMID:19274763 NCBI chr19:1,269,332...1,274,880
Ensembl chr19:1,259,384...1,274,880
JBrowse link
G CLCN3 chloride voltage-gated channel 3 increases expression ISO Acetazolamide results in increased expression of CLCN3 mRNA CTD PMID:19274763 NCBI chr 4:169,620,578...169,723,673
Ensembl chr 4:169,612,633...169,723,673
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked increases expression ISO Acetazolamide results in increased expression of DDX3X mRNA CTD PMID:19274763 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472
Ensembl chr  X:41,333,348...41,364,472
JBrowse link
G DDX6 DEAD-box helicase 6 increases expression ISO Acetazolamide results in increased expression of DDX6 mRNA CTD PMID:19274763 NCBI chr11:118,747,763...118,791,696
Ensembl chr11:118,747,763...118,791,164
JBrowse link
G DSC2 desmocollin 2 increases expression ISO Acetazolamide results in increased expression of DSC2 mRNA CTD PMID:19274763 NCBI chr18:31,058,840...31,102,421
Ensembl chr18:31,058,840...31,102,522
JBrowse link
G GLG1 golgi glycoprotein 1 increases expression ISO Acetazolamide results in increased expression of GLG1 mRNA CTD PMID:19274763 NCBI chr16:74,447,440...74,607,114
Ensembl chr16:74,447,427...74,607,144
JBrowse link
G GLUL glutamate-ammonia ligase increases expression ISO Acetazolamide results in increased expression of GLUL mRNA CTD PMID:19274763 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,381,704...182,392,206
Ensembl chr 1:182,381,704...182,392,206
JBrowse link
G HTRA1 HtrA serine peptidase 1 increases expression ISO Acetazolamide results in increased expression of HTRA1 mRNA CTD PMID:19274763 NCBI chr10:122,461,553...122,514,907
Ensembl chr10:122,458,551...122,514,907
JBrowse link
G IGF1R insulin like growth factor 1 receptor increases expression ISO Acetazolamide results in increased expression of IGF1R mRNA CTD PMID:19274763 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G ITPR2 inositol 1,4,5-trisphosphate receptor type 2 increases expression ISO Acetazolamide results in increased expression of ITPR2 mRNA CTD PMID:19274763 NCBI chr12:26,335,352...26,833,197
Ensembl chr12:26,335,352...26,833,194
JBrowse link
G MAB21L2 mab-21 like 2 decreases expression ISO Acetazolamide results in decreased expression of MAB21L2 mRNA CTD PMID:19274763 NCBI chr 4:150,582,151...150,584,693
Ensembl chr 4:150,582,151...150,584,693
JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 increases expression ISO Acetazolamide results in increased expression of MAP3K1 mRNA CTD PMID:19274763 NCBI chr 5:56,815,543...56,896,152
Ensembl chr 5:56,815,549...56,896,152
JBrowse link
G MT1X metallothionein 1X decreases expression ISO Acetazolamide results in decreased expression of MT1 mRNA CTD PMID:19274763 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit increases expression ISO Acetazolamide results in increased expression of NAA15 mRNA CTD PMID:19274763 NCBI chr 4:139,301,499...139,391,384
Ensembl chr 4:139,301,505...139,420,033
JBrowse link
G NDRG1 N-myc downstream regulated 1 increases expression ISO Acetazolamide results in increased expression of NDRG1 mRNA CTD PMID:19274763 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022
Ensembl chr 8:133,237,175...133,302,022
JBrowse link
G NRIP1 nuclear receptor interacting protein 1 increases expression ISO Acetazolamide results in increased expression of NRIP1 mRNA CTD PMID:19274763 NCBI chr21:14,961,235...15,065,903
Ensembl chr21:14,961,235...15,065,936
JBrowse link
G PEG3 paternally expressed 3 increases expression ISO Acetazolamide results in increased expression of PEG3 mRNA CTD PMID:19274763 NCBI chr19:56,810,082...56,840,726
Ensembl chr19:56,810,077...56,840,728
JBrowse link
G POU2F1 POU class 2 homeobox 1 increases expression ISO Acetazolamide results in increased expression of POU2F1 mRNA CTD PMID:19274763 NCBI chr 1:167,220,878...167,427,345
Ensembl chr 1:167,220,876...167,427,345
JBrowse link
G PPM1B protein phosphatase, Mg2+/Mn2+ dependent 1B increases expression ISO Acetazolamide results in increased expression of PPM1B mRNA CTD PMID:19274763 NCBI chr 2:44,168,853...44,247,330
Ensembl chr 2:44,167,969...44,244,384
JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha increases expression ISO Acetazolamide results in increased expression of PPP3CA mRNA CTD PMID:19274763 NCBI chr 4:101,023,418...101,348,295
Ensembl chr 4:101,023,409...101,348,278
JBrowse link
G RBM39 RNA binding motif protein 39 increases expression ISO Acetazolamide results in increased expression of RBM39 mRNA CTD PMID:19274763 NCBI chr20:35,701,347...35,742,262
Ensembl chr20:35,701,347...35,742,312
JBrowse link
G RBMX RNA binding motif protein X-linked increases expression ISO Acetazolamide results in increased expression of RBMX mRNA CTD PMID:19274763 NCBI chr  X:136,869,192...136,880,725
Ensembl chr  X:136,848,004...136,880,764
JBrowse link
G SATB1 SATB homeobox 1 increases expression ISO Acetazolamide results in increased expression of SATB1 mRNA CTD PMID:19274763 NCBI chr 3:18,345,377...18,445,592
Ensembl chr 3:18,345,377...18,445,588
JBrowse link
G SC5D sterol-C5-desaturase increases expression ISO Acetazolamide results in increased expression of SC5D mRNA CTD PMID:19274763 NCBI chr11:121,292,771...121,313,410
Ensembl chr11:121,292,681...121,313,410
JBrowse link
G SCHIP1 schwannomin interacting protein 1 increases expression ISO Acetazolamide results in increased expression of SCHIP1 mRNA CTD PMID:19274763 NCBI chr 3:159,273,244...159,897,359
Ensembl chr 3:158,962,235...159,897,366
Ensembl chr 3:158,962,235...159,897,366
JBrowse link
G SDC4 syndecan 4 increases expression ISO Acetazolamide results in increased expression of SDC4 mRNA CTD PMID:19274763 NCBI chr20:45,325,288...45,348,424
Ensembl chr20:45,325,288...45,348,424
JBrowse link
G SEMA4B semaphorin 4B increases expression ISO Acetazolamide results in increased expression of SEMA4B mRNA CTD PMID:19274763 NCBI chr15:90,184,920...90,229,679
Ensembl chr15:90,160,604...90,229,679
JBrowse link
G SF3B1 splicing factor 3b subunit 1 increases expression ISO Acetazolamide results in increased expression of SF3B1 mRNA CTD PMID:19274763 NCBI chr 2:197,389,784...197,435,093
Ensembl chr 2:197,388,515...197,435,091
Ensembl chr 2:197,388,515...197,435,091
JBrowse link
G SFMBT2 Scm like with four mbt domains 2 increases expression ISO Acetazolamide results in increased expression of SFMBT2 mRNA CTD PMID:19274763 NCBI chr10:7,158,624...7,411,490
Ensembl chr10:7,158,624...7,411,486
JBrowse link
G SHOX2 short stature homeobox 2 increases expression ISO Acetazolamide results in increased expression of SHOX2 mRNA CTD PMID:19274763 NCBI chr 3:158,095,905...158,106,420
Ensembl chr 3:158,095,954...158,106,503
JBrowse link
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 increases expression ISO Acetazolamide results in increased expression of SMARCC1 mRNA CTD PMID:19274763 NCBI chr 3:47,585,269...47,781,893
Ensembl chr 3:47,585,269...47,782,106
JBrowse link
G STX3 syntaxin 3 increases expression ISO Acetazolamide results in increased expression of STX3 mRNA CTD PMID:19274763 NCBI chr11:59,755,374...59,805,879
Ensembl chr11:59,713,456...59,805,882
JBrowse link
G STYX serine/threonine/tyrosine interacting protein increases expression ISO Acetazolamide results in increased expression of STYX mRNA CTD PMID:19274763 NCBI chr14:52,730,159...52,774,989
Ensembl chr14:52,730,166...52,774,989
JBrowse link
G TIA1 TIA1 cytotoxic granule associated RNA binding protein increases expression ISO Acetazolamide results in increased expression of TIA1 mRNA CTD PMID:19274763 NCBI chr 2:70,209,444...70,248,793
Ensembl chr 2:70,209,444...70,248,660
JBrowse link
G TMEM30B transmembrane protein 30B increases expression ISO Acetazolamide results in increased expression of TMEM30B mRNA CTD PMID:19274763 NCBI chr14:61,277,370...61,281,338
Ensembl chr14:61,277,370...61,281,761
JBrowse link
G TRIM25 tripartite motif containing 25 increases expression ISO Acetazolamide results in increased expression of TRIM25 mRNA CTD PMID:19274763 NCBI chr17:56,887,909...56,914,049
Ensembl chr17:56,836,387...56,914,080
JBrowse link
G UMOD uromodulin increases expression EXP Acetazolamide results in increased expression of UMOD protein CTD PMID:2655449 NCBI chr16:20,333,051...20,356,301
Ensembl chr16:20,333,052...20,356,301
JBrowse link
G WNK1 WNK lysine deficient protein kinase 1 increases expression ISO Acetazolamide results in increased expression of WNK1 mRNA CTD PMID:19274763 NCBI chr12:752,579...911,452
Ensembl chr12:752,579...911,452
JBrowse link
G ZNF322 zinc finger protein 322 increases expression ISO Acetazolamide results in increased expression of ZFP322A mRNA CTD PMID:19274763 NCBI chr 6:26,634,383...26,659,746
Ensembl chr 6:26,634,383...26,659,752
JBrowse link
G ZNF563 zinc finger protein 563 increases expression ISO Acetazolamide results in increased expression of ZFP617 mRNA CTD PMID:19274763 NCBI chr19:12,317,477...12,347,390
Ensembl chr19:12,317,477...12,333,720
JBrowse link
amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAN aggrecan affects expression ISO Amiloride affects the expression of ACAN mRNA CTD PMID:20454829 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G AGT angiotensinogen multiple interactions
increases expression
ISO
EXP
Amiloride inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]
Amiloride results in increased expression of AGT protein modified form
CTD PMID:7357812, PMID:14630723 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Amiloride results in decreased phosphorylation of and results in decreased activity of AKT1 protein; Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of AKT1 protein] CTD PMID:15607733, PMID:16059913 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin multiple interactions ISO Amiloride inhibits the reaction [ALB protein results in increased expression of CCL2 protein] CTD PMID:11340305 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G AOC1 amine oxidase copper containing 1 affects binding
multiple interactions
decreases activity
EXP Amiloride binds to AOC1 protein
Amiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]
Amiloride results in decreased activity of AOC1 protein
CTD PMID:2217167, PMID:8144586 NCBI chr 7:150,824,875...150,861,504
Ensembl chr 7:150,824,627...150,861,504
JBrowse link
G ASIC3 acid sensing ion channel subunit 3 affects response to substance ISO ASIC3 protein affects the susceptibility to Amiloride CTD PMID:12037186 NCBI chr 7:151,048,292...151,052,756
Ensembl chr 7:151,048,292...151,052,756
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO Amiloride inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATP6V1B1 ATPase H+ transporting V1 subunit B1 multiple interactions ISO [Furosemide co-treated with Amiloride] results in increased expression of ATP6V1B1 protein CTD PMID:17311909 NCBI chr 2:70,935,900...70,965,431
Ensembl chr 2:70,935,900...70,965,431
JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H multiple interactions ISO
EXP
Amiloride inhibits the reaction [CACNA1H protein results in increased transport of Calcium] CTD PMID:9930755, PMID:11897840 NCBI chr16:1,153,106...1,221,769
Ensembl chr16:1,153,106...1,221,771
JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions ISO Amiloride inhibits the reaction [Acids results in increased secretion of CALCA protein] CTD PMID:20100279 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15607733, PMID:16059913 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:15607733, PMID:16059913 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:16059913 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
Amiloride results in decreased expression of CCL2 mRNA; Amiloride results in decreased expression of CCL2 protein
Amiloride inhibits the reaction [ALB protein results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Amiloride results in decreased expression of CCL2 protein]
CTD PMID:11340305, PMID:12107048 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions ISO Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein] CTD PMID:11420121 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCNB1 cyclin B1 decreases expression EXP Amiloride results in decreased expression of CCNB1 protein CTD PMID:9458082 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CFTR CF transmembrane conductance regulator increases activity ISO Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G COL2A1 collagen type II alpha 1 chain affects expression ISO Amiloride affects the expression of COL2A1 mRNA CTD PMID:20454829 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL2 protein] CTD PMID:11420121 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Amiloride inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Amiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Amiloride promotes the reaction [TNFSF10 protein affects the localization of CYCS protein] CTD PMID:15607733 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased expression of DDIT3] CTD PMID:20015086 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DYSF dysferlin decreases expression EXP Amiloride results in decreased expression of DYSF mRNA CTD PMID:15535137 NCBI chr 2:71,453,154...71,686,763
Ensembl chr 2:71,453,722...71,686,768
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation ISO Amiloride results in increased phosphorylation of EIF2A protein CTD PMID:20015086 NCBI chr 3:150,546,726...150,586,016
Ensembl chr 3:150,546,678...150,586,016
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 decreases phosphorylation EXP Amiloride results in decreased phosphorylation of ERBB2 protein CTD PMID:16059913 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased phosphorylation of and results in increased activity of ERN1 protein] CTD PMID:20015086 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,142...64,130,819
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP
ISO
Amiloride results in increased expression of FOS mRNA
Amiloride inhibits the reaction [Acids results in increased expression of and results in increased localization of FOS protein]
CTD PMID:12730611, PMID:16769263 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G GRIP1 glutamate receptor interacting protein 1 affects response to substance EXP GRIP1 gene SNP affects the susceptibility to Amiloride CTD PMID:25622337 NCBI chr12:66,347,431...67,069,338
Ensembl chr12:66,347,431...67,069,162
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 mRNA]; Amiloride inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein] CTD PMID:20015086 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G IFNA2 interferon alpha 2 multiple interactions EXP Amiloride inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA] CTD PMID:12070711 NCBI chr 9:21,384,255...21,385,398
Ensembl chr 9:21,384,255...21,385,398
JBrowse link
G IFNG interferon gamma multiple interactions EXP
ISO
Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA]
Amiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein]
CTD PMID:11420121, PMID:12070711 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL12B interleukin 12B multiple interactions ISO Amiloride inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of IL12B protein] CTD PMID:11420121 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Amiloride inhibits the reaction [IL1B protein results in increased expression of SELE protein]; Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Amiloride inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G ITGAL integrin subunit alpha L multiple interactions ISO Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein] CTD PMID:10198263 NCBI chr16:30,472,683...30,523,185
Ensembl chr16:30,472,719...30,523,185
JBrowse link
G KLK1 kallikrein 1 multiple interactions
increases response to substance
ISO KLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]
KLK1 protein results in increased susceptibility to Amiloride
CTD PMID:18086683 NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein] CTD PMID:12065299 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Amiloride inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12065299 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO Amiloride inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK8 protein] CTD PMID:19815690 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions ISO Amiloride inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK9 protein] CTD PMID:19815690 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G MYF5 myogenic factor 5 increases expression EXP Amiloride results in increased expression of MYF5 mRNA CTD PMID:15535137 NCBI chr12:80,716,912...80,719,671
Ensembl chr12:80,716,912...80,719,671
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299, PMID:12107048 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased degradation of and results in decreased expression of NFKBIA protein] CTD PMID:12107048 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Lipopolysaccharides inhibits the reaction [Amiloride results in increased expression of NOS2] CTD PMID:21356098 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:15607733, PMID:16059913 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 decreases phosphorylation EXP Amiloride results in decreased phosphorylation of PDPK1 protein CTD PMID:16059913 NCBI chr16:2,538,014...2,603,190
Ensembl chr16:2,537,979...2,603,188
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 decreases uptake EXP Amiloride results in decreased uptake of PDX1 protein CTD PMID:16405074 NCBI chr13:27,919,982...27,926,313
Ensembl chr13:27,920,000...27,926,313
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel multiple interactions EXP Amiloride results in decreased activity of [PKD2 protein binds to PKD2 protein]; Amiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein] CTD PMID:19193631 NCBI chr 4:88,007,635...88,077,779
Ensembl chr 4:88,007,635...88,077,777
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions
decreases activity
EXP Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein]
Amiloride results in decreased activity of PLAU protein
CTD PMID:8921802, PMID:11454671, PMID:14644129 NCBI chr10:73,909,182...73,917,497
Ensembl chr10:73,909,177...73,917,496
JBrowse link
G PLAUR plasminogen activator, urokinase receptor multiple interactions EXP Amiloride inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA]; Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA] CTD PMID:12070711 NCBI chr19:43,646,095...43,670,197
Ensembl chr19:43,646,095...43,670,547
JBrowse link
G PLG plasminogen multiple interactions EXP Amiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein] CTD PMID:14644129 NCBI chr 6:160,702,193...160,754,097
Ensembl chr 6:160,702,238...160,754,097
Ensembl chr 6:160,702,238...160,754,097
JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha decreases phosphorylation
multiple interactions
EXP Amiloride results in decreased phosphorylation of PPP1CA protein
Okadaic Acid inhibits the reaction [Amiloride results in decreased phosphorylation of PPP1CA protein]
CTD PMID:16059913 NCBI chr11:67,398,183...67,401,858
Ensembl chr11:67,398,183...67,421,183
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Amiloride inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:17237260 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Amiloride inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Amiloride inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299, PMID:12107048 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SCNN1A sodium channel epithelial 1 subunit alpha multiple interactions
affects activity
EXP
ISO
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
[farglitazar co-treated with Amiloride] results in increased expression of SCNN1A mRNA
Amiloride affects the activity of SCNN1A protein
CTD PMID:8617496, PMID:15475592, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr12:6,346,847...6,377,359
Ensembl chr12:6,346,843...6,377,730
JBrowse link
G SCNN1B sodium channel epithelial 1 subunit beta multiple interactions
affects activity
EXP
ISO
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
Amiloride affects the activity of SCNN1B protein
CTD PMID:8617496, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr16:23,278,231...23,381,295
Ensembl chr16:23,278,231...23,381,294
JBrowse link
G SCNN1D sodium channel epithelial 1 subunit delta multiple interactions EXP Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D] CTD PMID:19359370 NCBI chr 1:1,280,436...1,292,025
Ensembl chr 1:1,280,436...1,292,029
JBrowse link
G SCNN1G sodium channel epithelial 1 subunit gamma affects activity
multiple interactions
ISO
EXP
Amiloride affects the activity of SCNN1G protein
Amiloride inhibits the reaction [[SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein] which results in increased transport of Sodium]; Amiloride results in decreased activity of [SCNN1A binds to SCNN1B binds to SCNN1G binds to SCNN1D]; Amiloride results in decreased activity of [SCNN1A protein binds to SCNN1B protein binds to SCNN1G protein]
CTD PMID:8617496, PMID:18398334, PMID:18665318, PMID:19359370 NCBI chr16:23,182,745...23,216,883
Ensembl chr16:23,182,745...23,216,883
JBrowse link
G SELE selectin E multiple interactions EXP Amiloride inhibits the reaction [IL1B protein results in increased expression of SELE protein] CTD PMID:12107048 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SLC12A4 solute carrier family 12 member 4 multiple interactions ISO Amiloride inhibits the reaction [SLC12A4 protein results in increased transport of Potassium] CTD PMID:11703599 NCBI chr16:67,943,474...67,968,694
Ensembl chr16:67,943,474...67,969,601
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Amiloride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC26A4 solute carrier family 26 member 4 multiple interactions ISO [Furosemide co-treated with Amiloride] affects the localization of SLC26A4 protein CTD PMID:17311909 NCBI chr 7:107,660,828...107,717,809
Ensembl chr 7:107,660,828...107,717,809
JBrowse link
G SLC31A1 solute carrier family 31 member 1 multiple interactions EXP Amiloride inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases activity
multiple interactions
EXP Amiloride results in decreased activity of SLC47A1 protein
Amiloride inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:16928787, PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Amiloride inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G SLC52A3 solute carrier family 52 member 3 multiple interactions ISO Amiloride inhibits the reaction [SLC52A3 protein results in increased transport of Riboflavin] CTD PMID:19122205 NCBI chr20:760,080...775,985
Ensembl chr20:760,080...776,015
JBrowse link
G SLC9A2 solute carrier family 9 member A2 multiple interactions ISO [Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Chlorides; [Amiloride results in decreased activity of SLC9A2 protein] which results in decreased transport of Sodium CTD PMID:10958346 NCBI chr 2:102,619,553...102,711,355
Ensembl chr 2:102,619,553...102,711,355
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]; Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein]; Lipopolysaccharides inhibits the reaction [Amiloride results in increased expression of TNF] CTD PMID:10198263, PMID:21356098 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions EXP Amiloride promotes the reaction [TNFSF10 protein affects the localization of CYCS protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP3 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP8 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of and results in increased activity of CASP9 protein]; Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Okadaic Acid inhibits the reaction [Amiloride promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] CTD PMID:15607733, PMID:16059913 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 multiple interactions ISO Amiloride inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein] CTD PMID:15843607 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 multiple interactions EXP Amiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein] CTD PMID:19193631 NCBI chr 3:142,724,034...142,807,888
Ensembl chr 3:142,724,034...142,807,888
JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 decreases activity ISO Amiloride results in decreased activity of TRPC6 protein CTD PMID:11179201 NCBI chr11:101,451,470...101,584,007
Ensembl chr11:101,451,564...101,872,562
JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression EXP Amiloride results in decreased expression of VEGFA mRNA; Amiloride results in decreased expression of VEGFA protein CTD PMID:16884771 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G XBP1 X-box binding protein 1 multiple interactions ISO Amiloride inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA] CTD PMID:20015086 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
azosemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC12A2 solute carrier family 12 member 2 decreases activity
multiple interactions
ISO
EXP
azosemide results in decreased activity of SLC12A2 protein
azosemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:15517342, PMID:29959396 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
bendroflumethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOB apolipoprotein B affects expression EXP Bendroflumethiazide affects the expression of APOB protein CTD PMID:2344503 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G REN renin increases expression EXP Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC12A3 solute carrier family 12 member 3 increases response to substance ISO SLC12A3 protein results in increased susceptibility to Bendroflumethiazide CTD PMID:18480177 NCBI chr16:56,865,207...56,915,850
Ensembl chr16:56,865,207...56,915,850
JBrowse link
G SLC22A6 solute carrier family 22 member 6 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC22A8 solute carrier family 22 member 8 decreases activity
increases secretion
ISO Bendroflumethiazide results in decreased activity of SLC22A8 protein
SLC22A8 protein results in increased secretion of Bendroflumethiazide
CTD PMID:18216144 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
G TPMT thiopurine S-methyltransferase decreases activity EXP Bendroflumethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr 6:18,128,311...18,155,169
Ensembl chr 6:18,128,311...18,155,077
JBrowse link
G VEGFC vascular endothelial growth factor C decreases expression ISO Bendroflumethiazide results in decreased expression of VEGFC protein CTD PMID:20625077 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link
bumetanide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 increases transport EXP ABCC4 protein results in increased transport of Bumetanide CTD PMID:17939016 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G CFTR CF transmembrane conductance regulator decreases activity EXP Bumetanide results in decreased activity of CFTR protein CTD PMID:15131065, PMID:15802612 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G F2RL1 F2R like trypsin receptor 1 multiple interactions EXP Bumetanide inhibits the reaction [F2RL1 protein results in increased transport of Chlorides] CTD PMID:11804840 NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315
JBrowse link
G HLA-G major histocompatibility complex, class I, G affects expression EXP Bumetanide affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr 6:29,826,474...29,831,130
Ensembl chr 6:29,826,967...29,831,125
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases expression ISO Bumetanide results in increased expression of PTGS1 mRNA CTD PMID:14504926 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G REN renin multiple interactions
increases expression
increases secretion
EXP
ISO
[Bumetanide co-treated with trandolapril] results in increased expression of REN protein; Indomethacin inhibits the reaction [Bumetanide results in increased activity of REN protein]; Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein]
Bumetanide results in increased expression of REN mRNA
Bumetanide results in increased expression of REN protein
CTD PMID:6756707, PMID:7040495, PMID:14504926, PMID:16635047 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC12A2 solute carrier family 12 member 2 increases response to substance
multiple interactions
decreases activity
ISO
EXP
SLC12A2 results in increased susceptibility to Bumetanide
Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Bumetanide results in decreased activity of SLC12A2 protein
[calyculin A results in increased phosphorylation of SLC12A2 protein] inhibits the reaction [Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Bumetanide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Bumetanide inhibits the reaction [SLC12A2 gene mutant form promotes the reaction [Glucose results in increased secretion of INS1 protein]]
Bumetanide results in decreased activity of SLC12A2 protein; Bumetanide results in decreased activity of SLC12A2 protein mutant form
CTD PMID:12556450, PMID:14630635, PMID:16709721, PMID:17259435, PMID:22872759, PMID:25817889, PMID:29959396 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
G SLC12A7 solute carrier family 12 member 7 decreases activity ISO Bumetanide results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 5:1,050,384...1,155,887
Ensembl chr 5:1,050,384...1,112,063
JBrowse link
G SLC17A3 solute carrier family 17 member 3 affects transport EXP SLC17A3 gene SNP affects the transport of Bumetanide CTD PMID:21282933 NCBI chr 6:25,844,856...25,874,243
Ensembl chr 6:25,833,066...25,882,286
JBrowse link
G SLC19A1 solute carrier family 19 member 1 multiple interactions
decreases activity
ISO Bumetanide inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Bumetanide results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr21:45,502,517...45,563,140
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SLC22A11 solute carrier family 22 member 11 multiple interactions EXP Bumetanide inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate] CTD PMID:10660625 NCBI chr11:64,555,847...64,572,875
Ensembl chr11:64,555,690...64,572,875
JBrowse link
G SLC22A7 solute carrier family 22 member 7 multiple interactions
increases transport
EXP Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
SLC22A7 protein results in increased transport of Bumetanide
CTD PMID:15901346 NCBI chr 6:43,295,710...43,305,538
Ensembl chr 6:43,295,694...43,305,538
JBrowse link
G SLC22A8 solute carrier family 22 member 8 multiple interactions ISO
EXP
Bumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
Bumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]
CTD PMID:10224140, PMID:11306713 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841
JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ACAN aggrecan decreases expression ISO Caffeine results in decreased expression of ACAN mRNA CTD PMID:29966748, PMID:32663519 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G ACAT2 acetyl-CoA acetyltransferase 2 decreases expression EXP Caffeine results in decreased expression of ACAT2 mRNA CTD PMID:11793227 NCBI chr 6:159,762,045...159,779,112
Ensembl chr 6:159,762,045...159,779,112
JBrowse link
G ACE angiotensin I converting enzyme decreases methylation
increases expression
ISO Caffeine results in decreased methylation of ACE promoter
Caffeine results in increased expression of ACE mRNA; Caffeine results in increased expression of ACE protein
CTD PMID:30423288 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) decreases activity
multiple interactions
ISO Caffeine results in decreased activity of ACHE protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein]
CTD PMID:28465162 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACIN1 apoptotic chromatin condensation inducer 1 increases expression EXP Caffeine results in increased expression of ACIN1 mRNA CTD PMID:11793227 NCBI chr14:23,058,564...23,095,614
Ensembl chr14:23,058,564...23,095,614
JBrowse link
G ACLY ATP citrate lyase increases expression ISO Caffeine results in increased expression of ACLY mRNA CTD PMID:30776459 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G ACSL3 acyl-CoA synthetase long chain family member 3 increases expression EXP Caffeine results in increased expression of ACSL3 mRNA CTD PMID:11793227 NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639
JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 decreases expression EXP Caffeine results in decreased expression of ACSL4 protein CTD PMID:31195006 NCBI chr  X:109,641,335...109,733,325
Ensembl chr  X:109,624,244...109,733,403
JBrowse link
G ACTA2 actin alpha 2, smooth muscle increases expression ISO Caffeine results in increased expression of ACTA2 mRNA CTD PMID:29055810 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ACTB actin beta decreases expression EXP Caffeine results in decreased expression of ACTB protein CTD PMID:31195006 NCBI chr 7:5,527,148...5,530,601
Ensembl chr 7:5,526,409...5,563,902
Ensembl chr 7:5,526,409...5,563,902
JBrowse link
G ACTBL2 actin beta like 2 increases expression EXP Caffeine results in increased expression of ACTBL2 protein CTD PMID:31195006 NCBI chr 5:57,480,018...57,482,811
Ensembl chr 5:57,480,018...57,482,811
JBrowse link
G ACTL6B actin like 6B increases expression EXP Caffeine results in increased expression of ACTL6B protein CTD PMID:31195006 NCBI chr 7:100,643,097...100,656,448
Ensembl chr 7:100,643,097...100,656,448
JBrowse link
G ACTR1A actin related protein 1A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr10:102,479,229...102,502,712
Ensembl chr10:102,461,881...102,502,712
JBrowse link
G ADA adenosine deaminase increases expression ISO Caffeine results in increased expression of ADA protein CTD PMID:6149265 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 increases expression ISO Caffeine results in increased expression of ADAMTS5 mRNA CTD PMID:31874197 NCBI chr21:26,917,922...26,967,758
Ensembl chr21:26,917,922...26,967,088
JBrowse link
G ADARB1 adenosine deaminase RNA specific B1 decreases expression ISO Caffeine results in decreased expression of ADARB1 mRNA CTD PMID:20864626 NCBI chr21:45,074,578...45,226,563
Ensembl chr21:45,073,853...45,226,560
JBrowse link
G ADCY5 adenylate cyclase 5 decreases expression ISO Caffeine results in decreased expression of ADCY5 mRNA CTD PMID:26367767 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090
JBrowse link
G ADCY7 adenylate cyclase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr16:50,246,138...50,318,135
Ensembl chr16:50,246,137...50,318,135
JBrowse link
G ADGRL1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:14,147,737...14,206,245
Ensembl chr19:14,147,743...14,206,187
JBrowse link
G ADIPOR2 adiponectin receptor 2 increases expression ISO Caffeine results in increased expression of ADIPOR2 mRNA CTD PMID:22583948 NCBI chr12:1,691,059...1,788,674
Ensembl chr12:1,688,574...1,788,674
JBrowse link
G ADORA1 adenosine A1 receptor multiple interactions
decreases expression
decreases activity
increases expression
ISO
EXP
[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine; [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA; [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA
Caffeine deficiency results in decreased expression of ADORA1 mRNA
Caffeine results in decreased activity of ADORA1 protein
Caffeine results in decreased expression of ADORA1 mRNA
Caffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]; Caffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]
Caffeine results in increased expression of ADORA1 protein
CTD PMID:3003150, PMID:7996441, PMID:10401785, PMID:12153486, PMID:15708489, PMID:22164264, PMID:23611293, PMID:29107002, PMID:29882086 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G ADORA2A adenosine A2a receptor affects response to substance
decreases expression
multiple interactions
decreases activity
increases response to substance
affects binding
ISO
EXP
ADORA2A protein affects the susceptibility to Caffeine
Caffeine results in decreased expression of ADORA2A mRNA
Caffeine results in decreased expression of ADORA2A mRNA; Caffeine results in decreased expression of ADORA2A protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]
ADORA2A polymorphism affects the susceptibility to Caffeine
Caffeine results in decreased activity of ADORA2A protein
ADORA2A polymorphism results in increased susceptibility to Caffeine; ADORA2A SNP results in increased susceptibility to Caffeine
Caffeine analog binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to and results in decreased activity of ADORA2A protein; Caffeine binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to ADORA2A protein
ADORA2A protein results in increased susceptibility to Caffeine
CTD PMID:10214707, PMID:11172060, PMID:12077927, PMID:12825092, PMID:15452191, PMID:16221767, PMID:16470403, PMID:16771831, PMID:18305461, PMID:20520601, PMID:21950736, PMID:23611293, PMID:26367767, PMID:30555576, PMID:30825513 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
JBrowse link
G ADORA2B adenosine A2b receptor multiple interactions
decreases expression
EXP
ISO
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
Caffeine results in decreased expression of ADORA2B mRNA
CTD PMID:22701600, PMID:26367767 NCBI chr17:15,927,782...15,975,746
Ensembl chr17:15,944,917...15,975,746
JBrowse link
G AGT angiotensinogen increases expression ISO Caffeine results in increased expression of AGT protein CTD PMID:30423288 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AGTR1 angiotensin II receptor type 1 increases expression
decreases expression
ISO Caffeine results in increased expression of AGTR1A
Caffeine results in decreased expression of AGTR1A mRNA
CTD PMID:25986755, PMID:30423288 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AGTR2 angiotensin II receptor type 2 decreases expression ISO Caffeine results in decreased expression of AGTR2 mRNA; Caffeine results in decreased expression of AGTR2 protein CTD PMID:25986755, PMID:30423288 NCBI chr  X:116,170,744...116,174,974
Ensembl chr  X:116,170,744...116,174,974
JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Caffeine results in decreased expression of AHCY protein CTD PMID:31195006 NCBI chr20:34,235,012...34,311,976
Ensembl chr20:34,280,268...34,311,802
JBrowse link
G AKAP9 A-kinase anchoring protein 9 decreases expression EXP Caffeine results in decreased expression of AKAP9 protein CTD PMID:31195006 NCBI chr 7:91,940,862...92,112,908
Ensembl chr 7:91,940,867...92,110,673
Ensembl chr 7:91,940,867...92,110,673
JBrowse link
G AKR1A1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of AKR1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 1:45,550,779...45,570,051
Ensembl chr 1:45,550,543...45,570,049
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
affects expression
decreases expression
decreases phosphorylation
increases phosphorylation
decreases response to substance
EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]
Caffeine affects the expression of AKT1 mRNA
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
Caffeine results in decreased expression of AKT1 mRNA; Caffeine results in decreased expression of AKT1 protein modified form
Caffeine results in decreased phosphorylation of AKT1 protein
AKT1 results in decreased susceptibility to Caffeine
CTD PMID:15126379, PMID:18201823, PMID:21081844, PMID:21561856, PMID:22974838, PMID:29966748, PMID:30528684 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALDH18A1 aldehyde dehydrogenase 18 family member A1 decreases expression EXP Caffeine results in decreased expression of ALDH18A1 mRNA CTD PMID:11793227 NCBI chr10:95,605,938...95,656,901
Ensembl chr10:95,605,941...95,656,711
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA] CTD PMID:20230807 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 increases expression ISO Caffeine results in increased expression of ALDH9A1 mRNA CTD PMID:20864626 NCBI chr 1:165,662,212...165,698,663
Ensembl chr 1:165,662,216...165,698,863
JBrowse link
G ALMS1 ALMS1 centrosome and basal body associated protein decreases expression ISO Caffeine results in decreased expression of ALMS1 mRNA CTD PMID:25868845 NCBI chr 2:73,385,758...73,609,919
Ensembl chr 2:73,385,758...73,625,166
JBrowse link
G ALPL alkaline phosphatase, biomineralization associated decreases expression ISO Caffeine results in decreased expression of ALPL mRNA CTD PMID:30423288, PMID:31874197 NCBI chr 1:21,508,984...21,578,412
Ensembl chr 1:21,509,397...21,578,410
JBrowse link
G ANG angiogenin decreases expression EXP Caffeine results in decreased expression of ANG mRNA CTD PMID:11793227 NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971
JBrowse link
G ANKRD37 ankyrin repeat domain 37 decreases expression ISO Caffeine results in decreased expression of ANKRD37 mRNA CTD PMID:20864626 NCBI chr 4:185,396,841...185,400,243
Ensembl chr 4:185,396,021...185,400,628
JBrowse link
G ANXA11 annexin A11 decreases expression EXP Caffeine results in decreased expression of ANXA11 protein CTD PMID:31195006 NCBI chr10:80,150,889...80,205,808
Ensembl chr10:80,150,889...80,205,572
JBrowse link
G ANXA4 annexin A4 decreases expression EXP Caffeine results in decreased expression of ANXA4 protein CTD PMID:31195006 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions
decreases expression
EXP
ISO
[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein
Caffeine results in decreased expression of APOA1 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOA2 apolipoprotein A2 multiple interactions
decreases expression
EXP
ISO
[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein
Caffeine results in decreased expression of APOA2 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr 1:161,222,292...161,223,628
Ensembl chr 1:161,222,292...161,223,631
JBrowse link
G APOB apolipoprotein B multiple interactions
decreases expression
EXP
ISO
[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein
[Caffeine co-treated with Dietary Fats] results in increased expression of APOB mRNA
Caffeine results in decreased expression of APOB mRNA
CTD PMID:16324916, PMID:25868845, PMID:29800656 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G APOC1 apolipoprotein C1 multiple interactions
decreases expression
EXP
ISO
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein
Caffeine results in decreased expression of APOC1 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349
JBrowse link
G APOC2 apolipoprotein C2 multiple interactions
decreases expression
EXP
ISO
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein
Caffeine results in decreased expression of APOC2 mRNA
CTD PMID:16324916, PMID:25868845 NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,945,971...44,949,566
Ensembl chr19:44,945,971...44,949,566
JBrowse link
G APOC3 apolipoprotein C3 multiple interactions EXP [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein CTD PMID:16324916 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
G APOM apolipoprotein M decreases expression ISO Caffeine results in decreased expression of APOM mRNA CTD PMID:25868845 NCBI chr 6:31,652,404...31,658,210
Ensembl chr 6:31,652,416...31,658,210
JBrowse link
G ARCN1 archain 1 decreases expression EXP Caffeine results in decreased expression of ARCN1 protein CTD PMID:31195006 NCBI chr11:118,572,396...118,603,033
Ensembl chr11:118,572,390...118,603,033
JBrowse link
G ARF1 ADP ribosylation factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr 1:228,082,708...228,099,212
Ensembl chr 1:228,082,660...228,099,212
JBrowse link
G ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 increases expression EXP Caffeine results in increased expression of ARL6IP1 mRNA CTD PMID:11793227 NCBI chr16:18,791,667...18,801,549
Ensembl chr16:18,791,669...18,801,572
JBrowse link
G ARRB2 arrestin beta 2 increases expression ISO Caffeine results in increased expression of ARRB2 mRNA CTD PMID:20864626 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) decreases expression EXP Caffeine results in decreased expression of ASNS mRNA CTD PMID:18444173 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ATG7 autophagy related 7 increases response to substance ISO ATG7 protein results in increased susceptibility to Caffeine; ATG7 results in increased susceptibility to Caffeine CTD PMID:21081844 NCBI chr 3:11,272,348...11,564,652
Ensembl chr 3:11,272,309...11,557,665
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions
decreases activity
EXP
ISO
[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
ATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]
CTD PMID:10531013, PMID:11507241, PMID:15975956, PMID:18347191, PMID:19028473, PMID:19038232, PMID:20734998, PMID:20888899, PMID:22927544, PMID:23274516, PMID:31168028 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects response to substance ISO ATP2A2 protein affects the susceptibility to Caffeine CTD PMID:19328205 NCBI chr12:110,281,247...110,351,093
Ensembl chr12:110,280,756...110,351,093
JBrowse link
G ATP5MF ATP synthase membrane subunit f decreases expression EXP Caffeine results in decreased expression of ATP5MF mRNA CTD PMID:11793227 NCBI chr 7:99,458,195...99,466,167
Ensembl chr 7:99,448,475...99,466,331
Ensembl chr 7:99,448,475...99,466,331
JBrowse link
G ATP6V0C ATPase H+ transporting V0 subunit c multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V0C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0C mRNA] CTD PMID:20230807 NCBI chr16:2,513,726...2,520,218
Ensembl chr16:2,513,952...2,520,218
JBrowse link
G ATP6V1B2 ATPase H+ transporting V1 subunit B2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V1B2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V1B2 mRNA] CTD PMID:20230807 NCBI chr 8:20,197,375...20,226,852
Ensembl chr 8:20,197,381...20,226,819
JBrowse link
G ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression ISO Caffeine results in decreased expression of ATPAF1 mRNA CTD PMID:20864626 NCBI chr 1:46,632,737...46,668,443
Ensembl chr 1:46,632,737...46,673,867
JBrowse link
G ATR ATR serine/threonine kinase affects activity
multiple interactions
EXP Caffeine affects the activity of ATR protein
[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
CTD PMID:11507241, PMID:15975956, PMID:18158334, PMID:20734998 NCBI chr 3:142,449,235...142,578,793
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G ATRN attractin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr20:3,471,018...3,651,118
Ensembl chr20:3,471,018...3,651,118
JBrowse link
G AVPR1A arginine vasopressin receptor 1A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr12:63,142,759...63,151,201
Ensembl chr12:63,142,759...63,150,942
Ensembl chr12:63,142,759...63,150,942
JBrowse link
G BASP1 brain abundant membrane attached signal protein 1 increases expression EXP Caffeine results in increased expression of BASP1 protein CTD PMID:31195006 NCBI chr 5:17,216,823...17,276,834
Ensembl chr 5:17,065,598...17,276,843
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP
ISO
Caffeine results in increased expression of BAX protein
[Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA
CTD PMID:12811820, PMID:12907610, PMID:31756439 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions EXP Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein] CTD PMID:19028473 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of BCL2L1 mRNA CTD PMID:31756439 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO Caffeine inhibits the reaction [aluminum chloride results in decreased expression of BDNF mRNA] CTD PMID:26339337 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions
ISO
EXP
Caffeine results in increased expression of BECN1 protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein]
CTD PMID:30555576 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein decreases expression ISO Caffeine results in decreased expression of BGLAP mRNA CTD PMID:30423288, PMID:31874197 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BHMT betaine--homocysteine S-methyltransferase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr 5:79,111,809...79,132,288
Ensembl chr 5:79,111,809...79,132,288
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP Caffeine inhibits the reaction [silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr10:131,967,683...131,982,013
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions EXP [Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form CTD PMID:21670593 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G C1R complement C1r multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr12:7,080,219...7,092,445
Ensembl chr12:7,080,214...7,092,540
JBrowse link
G C1S complement C1s multiple interactions ISO Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr12:7,060,718...7,071,032
Ensembl chr12:6,988,259...7,071,032
JBrowse link
G C2CD5 C2 calcium dependent domain containing 5 increases expression ISO Caffeine results in increased expression of C2CD5 mRNA CTD PMID:20864626 NCBI chr12:22,448,577...22,544,542
Ensembl chr12:22,448,583...22,544,546
JBrowse link
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression ISO Caffeine results in increased expression of CAD protein CTD PMID:6149265 NCBI chr 2:27,217,369...27,243,943
Ensembl chr 2:27,217,369...27,243,943
JBrowse link
G CALM1 calmodulin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CALM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CALU calumenin decreases expression EXP Caffeine results in decreased expression of CALU mRNA CTD PMID:11793227 NCBI chr 7:128,739,359...128,773,400
Ensembl chr 7:128,739,292...128,773,400
JBrowse link
G CAND1 cullin associated and neddylation dissociated 1 decreases expression EXP Caffeine results in decreased expression of CAND1 protein CTD PMID:31195006 NCBI chr12:67,269,358...67,319,953
Ensembl chr12:67,269,358...67,319,953
JBrowse link
G CAPN1 calpain 1 multiple interactions EXP [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CAPN2 calpain 2 decreases expression EXP Caffeine results in decreased expression of CAPN2 protein CTD PMID:31195006 NCBI chr 1:223,701,597...223,776,018
Ensembl chr 1:223,701,593...223,776,018
JBrowse link
G CASP2 caspase 2 multiple interactions EXP Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP2 protein] CTD PMID:16777994 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression
increases expression
increases cleavage
increases activity
affects cleavage
EXP
ISO
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein; Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP3 protein
Caffeine results in decreased expression of CASP3 protein modified form
Caffeine results in increased expression of CASP3 mRNA
Caffeine results in increased cleavage of CASP3 protein
Caffeine results in increased activity of CASP3 protein
[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
Caffeine affects the cleavage of CASP3 protein
CTD PMID:12378022, PMID:12395097, PMID:12907610, PMID:15537744, PMID:16522534, PMID:16777994, PMID:18201823, PMID:18283038, PMID:19242509, PMID:19490937, PMID:19815060, PMID:21081844, PMID:21229324, PMID:31874197 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions EXP
ISO
Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP9 protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]
CTD PMID:16522534, PMID:16777994, PMID:20230807 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases expression
increases expression
ISO Caffeine inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein]
Caffeine results in decreased expression of CAT mRNA
Caffeine results in increased expression of CAT protein
[Caffeine co-treated with Cadmium Chloride] results in decreased activity of CAT protein; [Caffeine co-treated with Cadmium Chloride] results in increased expression of CAT protein
CTD PMID:22154906, PMID:23099337, PMID:25868845 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV1 caveolin 1 increases expression EXP Caffeine results in increased expression of CAV1 protein CTD PMID:31195006 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,525,001...116,561,184
JBrowse link
G CAV3 caveolin 3 decreases expression ISO Caffeine results in decreased expression of CAV3 mRNA CTD PMID:25868845 NCBI chr 3:8,733,802...8,746,758
Ensembl chr 3:8,733,802...8,841,808
Ensembl chr 3:8,733,802...8,841,808
JBrowse link
G CBX5 chromobox 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr12:54,230,942...54,280,122
Ensembl chr12:54,230,942...54,280,133
JBrowse link
G CCDC124 coiled-coil domain containing 124 increases expression EXP Caffeine results in increased expression of CCDC124 protein CTD PMID:31195006 NCBI chr19:17,933,015...17,943,985
Ensembl chr19:17,933,015...17,943,991
JBrowse link
G CCDC174 coiled-coil domain containing 174 decreases expression ISO Caffeine results in decreased expression of CCDC174 mRNA CTD PMID:20864626 NCBI chr 3:14,651,762...14,672,659
Ensembl chr 3:14,651,746...14,672,659
JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases expression
decreases expression
EXP Caffeine results in increased expression of CCL3 mRNA
Caffeine results in decreased expression of CCL3 mRNA
CTD PMID:28089782 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCNB1 cyclin B1 multiple interactions
increases expression
ISO
EXP
Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein]
Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein]
Caffeine results in increased expression of CCNB1 protein
CTD PMID:9098629, PMID:19038232, PMID:20025956 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CCND1 cyclin D1 multiple interactions ISO Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:15126379 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNF cyclin F multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CCNF mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNF mRNA] CTD PMID:20230807 NCBI chr16:2,429,447...2,458,854
Ensembl chr16:2,429,394...2,458,854
JBrowse link
G CCNG1 cyclin G1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr 5:163,437,571...163,448,199
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CCNL2 cyclin L2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 1:1,385,711...1,399,336
Ensembl chr 1:1,385,711...1,399,335
JBrowse link
G CCT8 chaperonin containing TCP1 subunit 8 decreases expression EXP Caffeine results in decreased expression of CCT8 protein CTD PMID:31195006 NCBI chr21:29,056,326...29,073,648
Ensembl chr21:29,055,805...29,073,797
JBrowse link
G CCZ1B CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated decreases expression ISO Caffeine results in decreased expression of CCZ1 mRNA CTD PMID:20864626 NCBI chr 7:6,798,937...6,826,275
Ensembl chr 7:6,794,134...6,826,770
JBrowse link
G CD36 CD36 molecule multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD59 CD59 molecule (CD59 blood group) increases expression EXP Caffeine results in increased expression of CD59 protein CTD PMID:31195006 NCBI chr11:33,703,010...33,736,479
Ensembl chr11:33,703,010...33,736,491
Ensembl chr11:33,703,010...33,736,491
JBrowse link
G CD9 CD9 molecule decreases expression EXP Caffeine results in decreased expression of CD9 protein CTD PMID:31195006 NCBI chr12:6,199,946...6,238,266
Ensembl chr12:6,199,715...6,238,271
JBrowse link
G CDC14B cell division cycle 14B multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr 9:96,492,743...96,619,843
Ensembl chr 9:96,490,241...96,619,843
JBrowse link
G CDC25B cell division cycle 25B increases expression ISO Caffeine results in increased expression of CDC25B mRNA CTD PMID:20864626 NCBI chr20:3,786,951...3,806,118
Ensembl chr20:3,786,772...3,806,121
JBrowse link
G CDC25C cell division cycle 25C decreases expression
multiple interactions
EXP Caffeine results in decreased expression of CDC25C protein
Caffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of CDC25C protein]
CTD PMID:11835680, PMID:15975956 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDH1 cadherin 1 increases expression ISO Caffeine results in increased expression of CDH1 mRNA CTD PMID:20864626 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,541
JBrowse link
G CDH11 cadherin 11 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr16:64,943,753...65,126,112
Ensembl chr16:64,943,753...65,126,112
JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP
ISO
Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDK1 protein]; Caffeine results in decreased phosphorylation of and results in increased activity of CDK1 protein
Caffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]
CTD PMID:9098629, PMID:11835680, PMID:15975956, PMID:19038232 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases activity EXP Caffeine results in decreased activity of CDK2 protein CTD PMID:11835680 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 multiple interactions
decreases expression
ISO
EXP
Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein]
Caffeine results in decreased expression of CDK4 mRNA
CTD PMID:11793227, PMID:15126379 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP
ISO
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [entinostat results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]
CTD PMID:17977830, PMID:18223691, PMID:18347191, PMID:19735649, PMID:21840268, PMID:22927544, PMID:23274516, PMID:30555576 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha decreases expression
affects expression
increases expression
ISO Caffeine results in decreased expression of CEBPA mRNA
Caffeine affects the expression of CEBPA mRNA
Caffeine results in increased expression of CEBPA mRNA
CTD PMID:23727198, PMID:30423288, PMID:30528684, PMID:30776459 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta decreases expression ISO Caffeine results in decreased expression of CEBPB mRNA CTD PMID:30528684 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CEMIP2 cell migration inducing hyaluronidase 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr 9:71,683,366...71,769,532
Ensembl chr 9:71,683,366...71,816,690
JBrowse link
G CETN3 centrin 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 5:90,392,257...90,409,756
Ensembl chr 5:90,392,257...90,409,766
Ensembl chr 5:90,392,257...90,409,766
JBrowse link
G CFD complement factor D multiple interactions ISO [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] CTD PMID:2307116 NCBI chr19:859,664...863,641
Ensembl chr19:859,664...863,641
JBrowse link
G CHEK1 checkpoint kinase 1 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation
EXP
ISO
Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein]
Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
Caffeine results in decreased expression of CHEK1 protein modified form
Caffeine results in decreased phosphorylation of CHEK1 protein
CTD PMID:15975956, PMID:18158334, PMID:19261750, PMID:21505179, PMID:21561856, PMID:22403396, PMID:29074359 NCBI chr11:125,624,910...125,676,255
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions
decreases activity
EXP Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]; Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
Caffeine results in decreased activity of CHEK2 protein
CTD PMID:10531013, PMID:15975956, PMID:16777994, PMID:18158334, PMID:19038232, PMID:23274516 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CKMT1B creatine kinase, mitochondrial 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CKMT1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr15:43,592,857...43,599,406
Ensembl chr15:43,593,054...43,604,901
JBrowse link
G CLIC1 chloride intracellular channel 1 increases expression EXP Caffeine results in increased expression of CLIC1 protein CTD PMID:31195006 NCBI chr 6:31,730,581...31,737,318
Ensembl chr 6:31,730,581...31,739,763
JBrowse link
G CLSTN1 calsyntenin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 1:9,728,926...9,824,526
Ensembl chr 1:9,728,926...9,823,984
Ensembl chr 1:9,728,926...9,823,984
JBrowse link
G CNN2 calponin 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr19:1,026,608...1,039,065
Ensembl chr19:1,026,586...1,039,068
JBrowse link
G COBL cordon-bleu WH2 repeat protein affects expression ISO Caffeine affects the expression of COBL mRNA CTD PMID:20864626 NCBI chr 7:51,016,212...51,316,809
Ensembl chr 7:51,016,212...51,316,818
JBrowse link
G COCH cochlin decreases expression ISO Caffeine results in decreased expression of COCH mRNA CTD PMID:20864626 NCBI chr14:30,874,496...30,890,618
Ensembl chr14:30,874,514...30,895,065
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]
Caffeine results in decreased expression of COL1A1 mRNA
CTD PMID:20230807, PMID:24275088 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression ISO Caffeine results in decreased expression of COL2A1 mRNA; Caffeine results in decreased expression of COL2A1 protein CTD PMID:29966748, PMID:32663519 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G COMT catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G COQ8A coenzyme Q8A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COQ8A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COQ8A mRNA] CTD PMID:20230807 NCBI chr 1:226,939,339...226,987,544
Ensembl chr 1:226,897,536...226,987,545
JBrowse link
G CORT cortistatin decreases expression ISO Caffeine results in decreased expression of CORT protein CTD PMID:25868845 NCBI chr 1:10,450,031...10,451,998
Ensembl chr 1:10,449,719...10,451,902
Ensembl chr 1:10,449,719...10,451,902
JBrowse link
G COX7A2L cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7A2L mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 2:42,335,559...42,368,957
Ensembl chr 2:42,333,546...42,425,088
JBrowse link
G COX7C cytochrome c oxidase subunit 7C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 5:86,617,941...86,620,962
Ensembl chr 5:86,617,928...86,620,962
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression ISO Caffeine results in decreased expression of CPT1A mRNA CTD PMID:30776459 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREB1 cAMP responsive element binding protein 1 decreases expression EXP
ISO
Caffeine results in decreased expression of CREB1 mRNA CTD PMID:26367767 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRTC2 CREB regulated transcription coactivator 2 decreases expression EXP Caffeine results in decreased expression of CRTC2 protein CTD PMID:31195006 NCBI chr 1:153,947,675...153,958,643
Ensembl chr 1:153,947,669...153,958,615
JBrowse link
G CSNK2A2 casein kinase 2 alpha 2 decreases expression ISO Caffeine results in decreased expression of CSNK2A2 mRNA CTD PMID:20864626 NCBI chr16:58,157,907...58,198,106
Ensembl chr16:58,157,907...58,198,106
JBrowse link
G CST3 cystatin C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CST3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr20:23,626,706...23,637,955
Ensembl chr20:23,626,706...23,638,473
JBrowse link
G CTH cystathionine gamma-lyase multiple interactions ISO [Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA CTD PMID:29447158 NCBI chr 1:70,411,268...70,441,949
Ensembl chr 1:70,411,218...70,439,851
JBrowse link
G CTNNB1 catenin beta 1 increases mutagenesis
multiple interactions
ISO Caffeine results in increased mutagenesis of CTNNB1 gene
Caffeine inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]
CTD PMID:18283038, PMID:30377735 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CTSB cathepsin B multiple interactions EXP
ISO
[Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA]
CTD PMID:19490937, PMID:20230807 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G CTSD cathepsin D increases expression EXP Caffeine results in increased expression of CTSD protein CTD PMID:31195006 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G CTSL cathepsin L multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,726,109...87,731,469
JBrowse link
G CWC25 CWC25 spliceosome associated protein homolog decreases expression EXP Caffeine results in decreased expression of CWC25 protein CTD PMID:31195006 NCBI chr17:38,800,441...38,825,325
Ensembl chr17:38,800,441...38,825,355
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Caffeine results in increased expression of CXCL8 mRNA CTD PMID:28089782 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYC1 cytochrome c1 decreases expression EXP Caffeine results in decreased expression of CYC1 mRNA CTD PMID:11793227 NCBI chr 8:144,095,076...144,097,525
Ensembl chr 8:144,095,039...144,097,525
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases expression ISO Caffeine results in decreased expression of CYP11A1 mRNA CTD PMID:24717552, PMID:25868845 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 decreases expression ISO Caffeine results in decreased expression of CYP11B1 mRNA CTD PMID:25868845, PMID:29343424, PMID:30528684 NCBI chr 8:142,872,357...142,879,825
Ensembl chr 8:142,872,354...142,879,846
Ensembl chr 8:142,872,354...142,879,846
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 decreases expression ISO Caffeine results in decreased expression of CYP11B2 mRNA CTD PMID:25868845, PMID:29343424 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 increases expression ISO Caffeine results in increased expression of CYP17A1 mRNA CTD PMID:25868845 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 increases expression ISO Caffeine results in increased expression of CYP19A1 mRNA; Caffeine results in increased expression of CYP19A1 protein CTD PMID:28111094 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity ISO Caffeine results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects binding
multiple interactions
increases metabolic processing
decreases activity
affects metabolic processing
increases activity
decreases methylation
EXP
ISO
CYP1A2 protein binds to Caffeine
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]; CYP1A2 protein binds to and affects the metabolism of Caffeine; CYP1A2 protein binds to and results in increased metabolism of Caffeine; GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; Resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]
Caffeine results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of Caffeine; CYP1A2 protein affects the metabolism of Caffeine metabolite
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein binds to and affects the metabolism of Caffeine
Caffeine results in increased activity of CYP1A2 protein
CTD PMID:1302044, PMID:9334905, PMID:11145498, PMID:11376689, PMID:11465391, PMID:11907490, PMID:12433797, PMID:12706856, PMID:14586384, PMID:14586387, PMID:15022032, PMID:15199075, PMID:15286053, PMID:15327588, PMID:15619608, PMID:15659567, PMID:15822860, PMID:15856409, PMID:15980104, PMID:16934051, PMID:18420780, PMID:19215233, PMID:20716633, PMID:24211539, PMID:26599973, PMID:28843594, PMID:31132250 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity ISO Caffeine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP21A1P cytochrome P450 family 21 subfamily A member 1, pseudogene increases expression
decreases expression
ISO Caffeine results in increased expression of CYP21A1 mRNA
Caffeine results in decreased expression of CYP21A1 mRNA; Caffeine results in decreased expression of CYP21A2 mRNA
CTD PMID:24717552, PMID:25868845, PMID:30528684 NCBI chr 6:32,005,636...32,008,909
Ensembl chr 6:32,005,636...32,008,451
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions
decreases activity
increases metabolic processing
EXP
ISO
CYP2A6 protein affects the metabolism of and results in increased activity of Caffeine metabolite
Caffeine results in decreased activity of CYP2A4 protein
CYP2A6 protein results in increased metabolism of Caffeine
CTD PMID:12505289, PMID:17916905, PMID:18420780 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity ISO Caffeine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 affects metabolic processing EXP CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of Caffeine CTD PMID:1302044, PMID:14586387 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity EXP
ISO
Caffeine results in decreased activity of CYP3A4 protein CTD PMID:18420780, PMID:24211539 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP4B1 cytochrome P450 family 4 subfamily B member 1 increases expression EXP Caffeine results in increased expression of CYP4B1 mRNA CTD PMID:18444173 NCBI chr 1:46,799,046...46,819,413
Ensembl chr 1:46,757,838...46,819,413
JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Caffeine results in decreased expression of CYP7B1 mRNA CTD PMID:20864626 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737
JBrowse link
G DAD1 defender against cell death 1 decreases expression EXP Caffeine results in decreased expression of DAD1 mRNA CTD PMID:11793227 NCBI chr14:22,564,907...22,589,224
Ensembl chr14:22,564,907...22,589,224
JBrowse link
G DCAF11 DDB1 and CUL4 associated factor 11 decreases expression ISO Caffeine results in decreased expression of DCAF11 mRNA CTD PMID:20864626 NCBI chr14:24,114,777...24,125,242
Ensembl chr14:24,114,195...24,125,242
JBrowse link
G DCT dopachrome tautomerase increases expression EXP Caffeine results in increased expression of DCT mRNA CTD PMID:18444173 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G DCXR dicarbonyl and L-xylulose reductase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DCXR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DCXR mRNA] CTD PMID:20230807 NCBI chr17:82,035,858...82,037,697
Ensembl chr17:82,035,136...82,037,709
JBrowse link
G DDHD1 DDHD domain containing 1 increases expression ISO Caffeine results in increased expression of DDHD1 mRNA CTD PMID:20864626 NCBI chr14:53,036,755...53,153,323
Ensembl chr14:53,036,745...53,153,323
Ensembl chr14:53,036,745...53,153,323
JBrowse link
G DDX31 DEAD-box helicase 31 decreases expression ISO Caffeine results in decreased expression of DDX31 mRNA CTD PMID:20864626 NCBI chr 9:132,592,997...132,670,401
Ensembl chr 9:132,592,997...132,670,401
JBrowse link
G DDX39A DExD-box helicase 39A decreases expression EXP Caffeine results in decreased expression of DDX39A protein CTD PMID:31195006 NCBI chr19:14,408,798...14,419,383
Ensembl chr19:14,408,798...14,419,383
JBrowse link
G DHCR24 24-dehydrocholesterol reductase decreases expression ISO Caffeine results in decreased expression of DHCR24 mRNA CTD PMID:20864626 NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195
JBrowse link
G DHCR7 7-dehydrocholesterol reductase decreases expression ISO Caffeine results in decreased expression of DHCR7 mRNA CTD PMID:25868845 NCBI chr11:71,434,411...71,448,393
Ensembl chr11:71,428,193...71,452,868
JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) increases expression ISO Caffeine results in increased expression of DHODH protein CTD PMID:6149265 NCBI chr16:72,008,744...72,027,659
Ensembl chr16:72,008,588...72,027,664
JBrowse link
G DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 9:33,025,273...33,039,907
Ensembl chr 9:33,025,273...33,039,907
JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of DNAJB9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
JBrowse link
G DNAJC12 DnaJ heat shock protein family (Hsp40) member C12 increases expression EXP Caffeine results in increased expression of DNAJC12 protein CTD PMID:31195006 NCBI chr10:67,796,665...67,838,188
Ensembl chr10:67,796,669...67,838,188
JBrowse link
G DNMT1 DNA methyltransferase 1 increases expression ISO Caffeine results in increased expression of DNMT1 mRNA CTD PMID:24717552 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha increases expression ISO Caffeine results in increased expression of DNMT3A mRNA CTD PMID:24717552 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590
JBrowse link
G DNMT3B DNA methyltransferase 3 beta increases expression ISO Caffeine results in increased expression of DNMT3B mRNA CTD PMID:25868845, PMID:30423288 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G DPP4 dipeptidyl peptidase 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,215
JBrowse link
G DRD2 dopamine receptor D2 affects response to substance
increases response to substance
multiple interactions
EXP
ISO
DRD2 polymorphism affects the susceptibility to Caffeine
DRD2 protein results in increased susceptibility to Caffeine
Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]
CTD PMID:11172060, PMID:16889759, PMID:18305461 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DTX4 deltex E3 ubiquitin ligase 4 decreases expression ISO Caffeine results in decreased expression of DTX4 mRNA CTD PMID:20864626 NCBI chr11:59,171,430...59,208,588
Ensembl chr11:59,171,430...59,208,588
JBrowse link
G DUSP8 dual specificity phosphatase 8 increases expression ISO Caffeine results in increased expression of DUSP8 mRNA CTD PMID:9813294 NCBI chr11:1,554,051...1,572,839
Ensembl chr11:1,554,051...1,572,271
JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions ISO Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA] CTD PMID:22403396 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EBP EBP cholestenol delta-isomerase increases expression ISO Caffeine results in increased expression of EBP mRNA CTD PMID:25868845 NCBI chr  X:48,521,808...48,528,716
Ensembl chr  X:48,521,799...48,528,716
JBrowse link
G EBPL EBP like decreases expression ISO Caffeine results in decreased expression of EBPL mRNA CTD PMID:20864626 NCBI chr13:49,660,674...49,691,487
Ensembl chr13:49,660,674...49,691,486
JBrowse link
G ECI1 enoyl-CoA delta isomerase 1 decreases expression ISO Caffeine results in decreased expression of ECI1 mRNA CTD PMID:20864626 NCBI chr16:2,239,402...2,251,587
Ensembl chr16:2,239,402...2,252,300
JBrowse link
G ECM1 extracellular matrix protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ECM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 1:150,508,109...150,513,789
Ensembl chr 1:150,508,062...150,513,789
JBrowse link
G EDN1 endothelin 1 increases activity ISO Caffeine results in increased activity of EDN1 protein CTD PMID:1860718 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions
increases expression
ISO
EXP
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF1A1 mRNA]
Caffeine results in increased expression of EEF1A1 protein
CTD PMID:20230807, PMID:31195006 NCBI chr 6:73,515,750...73,521,032
Ensembl chr 6:73,515,750...73,523,797
JBrowse link
G EEF1D eukaryotic translation elongation factor 1 delta decreases expression EXP Caffeine results in decreased expression of EEF1D protein CTD PMID:31195006 NCBI chr 8:143,579,728...143,597,422
Ensembl chr 8:143,579,697...143,599,541
JBrowse link
G EEF1G eukaryotic translation elongation factor 1 gamma increases expression EXP Caffeine results in increased expression of EEF1G protein CTD PMID:31195006 NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086
JBrowse link
G EEF2 eukaryotic translation elongation factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA] CTD PMID:20230807 NCBI chr19:3,976,056...3,985,463
Ensembl chr19:3,976,056...3,985,463
JBrowse link
G EFNA1 ephrin A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA] CTD PMID:20230807 NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899
JBrowse link
G EFNB3 ephrin B3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNB3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr17:7,705,202...7,711,372
Ensembl chr17:7,705,202...7,711,372
JBrowse link
G EGR1 early growth response 1 increases expression
decreases expression
multiple interactions
ISO Caffeine results in increased expression of EGR1 mRNA
Caffeine results in decreased expression of EGR1 mRNA
[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]
[Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNA
CTD PMID:10971643, PMID:16771831 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G EHBP1 EH domain binding protein 1 increases expression EXP Caffeine results in increased expression of EHBP1 protein CTD PMID:31195006 NCBI chr 2:62,673,878...63,046,487
Ensembl chr 2:62,673,851...63,046,487
JBrowse link
G EHD1 EH domain containing 1 decreases expression EXP Caffeine results in decreased expression of EHD1 protein CTD PMID:31195006 NCBI chr11:64,851,642...64,879,693
Ensembl chr11:64,851,642...64,888,296
JBrowse link
G EHD2 EH domain containing 2 decreases expression EXP Caffeine results in decreased expression of EHD2 protein CTD PMID:31195006 NCBI chr19:47,713,422...47,743,134
Ensembl chr19:47,713,422...47,743,134
JBrowse link
G EIF1 eukaryotic translation initiation factor 1 increases expression EXP Caffeine results in increased expression of EIF1 mRNA CTD PMID:11793227 NCBI chr17:41,688,885...41,692,668
Ensembl chr17:41,688,885...41,692,668
JBrowse link
G EIF3B eukaryotic translation initiation factor 3 subunit B decreases expression EXP Caffeine results in decreased expression of EIF3B protein CTD PMID:31195006 NCBI chr 7:2,354,086...2,380,745
Ensembl chr 7:2,354,086...2,380,745
JBrowse link
G EIF4E eukaryotic translation initiation factor 4E multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA] CTD PMID:20230807 NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,871,684...98,930,637
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
increases expression
EXP
ISO
Caffeine results in decreased expression of EIF4EBP1 protein modified form
Caffeine results in increased expression of EIF4EBP1 protein
CTD PMID:21081844 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G EIF5 eukaryotic translation initiation factor 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EIF5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr14:103,334,237...103,345,025
Ensembl chr14:103,333,544...103,345,025
JBrowse link
G ELL elongation factor for RNA polymerase II decreases expression ISO Caffeine results in decreased expression of ELL mRNA CTD PMID:20864626 NCBI chr19:18,442,663...18,522,070
Ensembl chr19:18,442,663...18,522,116
JBrowse link
G EMC6 ER membrane protein complex subunit 6 decreases expression ISO Caffeine results in decreased expression of EMC6 mRNA CTD PMID:20864626 NCBI chr17:3,668,812...3,669,665
Ensembl chr17:3,668,812...3,669,668
JBrowse link
G ENDOD1 endonuclease domain containing 1 decreases expression ISO Caffeine results in decreased expression of ENDOD1 mRNA CTD PMID:20864626 NCBI chr11:95,089,846...95,132,645
Ensembl chr11:95,089,846...95,132,645
JBrowse link
G ENO1 enolase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G EPPK1 epiplakin 1 decreases expression EXP Caffeine results in decreased expression of EPPK1 protein CTD PMID:31195006 NCBI chr 8:143,857,319...143,879,043
Ensembl chr 8:143,857,324...143,878,467
Ensembl chr 8:143,857,324...143,878,467
JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr17:64,039,142...64,132,469
Ensembl chr17:64,039,142...64,130,819
JBrowse link
G ERP44 endoplasmic reticulum protein 44 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERP44 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 9:99,979,185...100,099,000
Ensembl chr 9:99,979,185...100,099,000
JBrowse link
G ESYT2 extended synaptotagmin 2 decreases expression ISO Caffeine results in decreased expression of ESYT2 mRNA CTD PMID:20864626 NCBI chr 7:158,730,997...158,829,577
Ensembl chr 7:158,730,995...158,830,253
JBrowse link
G ETV3 ETS variant transcription factor 3 increases expression EXP Caffeine results in increased expression of ETV3 protein CTD PMID:31195006 NCBI chr 1:157,121,191...157,138,575
Ensembl chr 1:157,121,191...157,138,474
JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 decreases expression EXP Caffeine results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 8:71,197,433...71,548,104
Ensembl chr 8:71,197,433...71,592,025
JBrowse link
G EZR ezrin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA] CTD PMID:20230807 NCBI chr 6:158,765,744...158,819,368
Ensembl chr 6:158,765,741...158,819,368
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression ISO Caffeine results in decreased expression of FABP4 mRNA CTD PMID:23727198 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FARSA phenylalanyl-tRNA synthetase subunit alpha increases expression EXP Caffeine results in increased expression of FARSA protein CTD PMID:31195006 NCBI chr19:12,922,479...12,933,711
Ensembl chr19:12,922,479...12,934,037
JBrowse link
G FAS Fas cell surface death receptor decreases expression ISO Caffeine results in decreased expression of FAS mRNA CTD PMID:29343424 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASN fatty acid synthase multiple interactions
increases expression
ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA
Caffeine results in increased expression of FASN mRNA; Caffeine results in increased expression of FASN protein
CTD PMID:28843594, PMID:30776459 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FASTKD3 FAST kinase domains 3 decreases expression ISO Caffeine results in decreased expression of FASTKD3 mRNA CTD PMID:20864626 NCBI chr 5:7,859,159...7,869,037
Ensembl chr 5:7,859,159...7,869,037
JBrowse link
G FAU FAU ubiquitin like and ribosomal protein S30 fusion increases expression EXP Caffeine results in increased expression of FAU protein CTD PMID:31195006 NCBI chr11:65,120,630...65,122,134
Ensembl chr11:65,120,630...65,122,177
JBrowse link
G FBLN2 fibulin 2 increases expression ISO Caffeine results in increased expression of FBLN2 mRNA CTD PMID:20864626 NCBI chr 3:13,549,125...13,638,408
Ensembl chr 3:13,549,125...13,638,422
JBrowse link
G FBRS fibrosin increases expression ISO Caffeine results in increased expression of FBRS mRNA CTD PMID:20864626 NCBI chr16:30,658,431...30,670,810
Ensembl chr16:30,658,431...30,670,810
JBrowse link
G FBXL12 F-box and leucine rich repeat protein 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of FBXL12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr19:9,810,267...9,820,528
Ensembl chr19:9,810,267...9,827,816
JBrowse link
G FBXL19 F-box and leucine rich repeat protein 19 decreases expression EXP Caffeine results in decreased expression of FBXL19 protein CTD PMID:31195006 NCBI chr16:30,922,851...30,948,783
Ensembl chr16:30,923,055...30,948,783
JBrowse link
G FCRL3 Fc receptor like 3 decreases expression EXP Caffeine results in decreased expression of FCRL3 protein CTD PMID:31195006 NCBI chr 1:157,676,481...157,700,985
Ensembl chr 1:157,674,321...157,700,769
JBrowse link
G FCSK fucose kinase increases expression ISO Caffeine results in increased expression of FCSK mRNA CTD PMID:20864626 NCBI chr16:70,454,590...70,480,274
Ensembl chr16:70,454,595...70,480,274
JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 decreases expression
increases expression
ISO Caffeine results in decreased expression of FDFT1 mRNA
Caffeine results in increased expression of FDFT1 mRNA
CTD PMID:20864626, PMID:25868845 NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,304
JBrowse link
G FDX1 ferredoxin 1 decreases expression ISO Caffeine results in decreased expression of FDX1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr11:110,429,948...110,464,884
Ensembl chr11:110,429,948...110,464,884
JBrowse link
G FHL1 four and a half LIM domains 1 increases expression ISO Caffeine results in increased expression of FHL1 mRNA CTD PMID:20864626 NCBI chr  X:136,146,702...136,211,359
Ensembl chr  X:136,146,702...136,211,359
JBrowse link
G FILIP1L filamin A interacting protein 1 like increases expression ISO Caffeine results in increased expression of FILIP1L mRNA CTD PMID:20864626 NCBI chr 3:99,833,144...100,114,501
Ensembl chr 3:99,830,141...100,114,513
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Caffeine results in increased expression of FOS mRNA
[Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA]
CTD PMID:10971643 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA] CTD PMID:20230807 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452
JBrowse link
G GALE UDP-galactose-4-epimerase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GALE mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GALE mRNA] CTD PMID:20230807 NCBI chr 1:23,795,599...23,800,754
Ensembl chr 1:23,795,599...23,800,781
JBrowse link
G GANAB glucosidase II alpha subunit decreases expression EXP Caffeine results in decreased expression of GANAB protein CTD PMID:31195006 NCBI chr11:62,624,829...62,646,613
Ensembl chr11:62,624,826...62,646,726
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GAST gastrin increases secretion ISO Caffeine results in increased secretion of GAST protein CTD PMID:19208342 NCBI chr17:41,712,331...41,715,969
Ensembl chr17:41,712,331...41,715,969
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GDF10 growth differentiation factor 10 decreases expression ISO Caffeine results in decreased expression of GDF10 mRNA CTD PMID:20864626 NCBI chr10:47,300,197...47,313,577
Ensembl chr10:47,300,197...47,313,577
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFAP protein]
Caffeine inhibits the reaction [aluminum chloride results in increased expression of GFAP protein]
CTD PMID:19882200, PMID:26339337 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GH1 growth hormone 1 multiple interactions EXP GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine] CTD PMID:11907490 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GHITM growth hormone inducible transmembrane protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GHITM mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr10:84,139,509...84,153,568
Ensembl chr10:84,139,509...84,153,568
JBrowse link
G GJA1 gap junction protein alpha 1 decreases expression ISO Caffeine results in decreased expression of GJA1 mRNA CTD PMID:28087314 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GLIDR glioblastoma down-regulated RNA decreases expression EXP Caffeine results in decreased expression of GLIDR protein CTD PMID:31195006 NCBI chr 9:39,803,496...39,810,159
Ensembl chr 9:39,748,514...39,810,097
JBrowse link
G GLRX glutaredoxin decreases expression EXP Caffeine results in decreased expression of GLRX mRNA CTD PMID:11793227 NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726
JBrowse link
G GLT8D1 glycosyltransferase 8 domain containing 1 decreases expression EXP Caffeine results in decreased expression of GLT8D1 mRNA CTD PMID:11793227 NCBI chr 3:52,694,486...52,705,796
Ensembl chr 3:52,694,488...52,706,032
JBrowse link
G GLUD1 glutamate dehydrogenase 1 decreases expression EXP Caffeine results in decreased expression of GLUD1 mRNA CTD PMID:11793227 NCBI chr10:87,050,202...87,094,843
Ensembl chr10:87,050,202...87,094,843
JBrowse link
G GMFB glia maturation factor beta multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr14:54,474,485...54,488,980
Ensembl chr14:54,474,484...54,489,026
JBrowse link
G GNAI1 G protein subunit alpha i1 decreases expression
increases expression
ISO Caffeine results in decreased expression of GNAI1 protein
Caffeine results in increased expression of GNAI1 mRNA
CTD PMID:15708489 NCBI chr 7:80,134,831...80,226,181
Ensembl chr 7:79,768,028...80,226,181
JBrowse link
G GNAI2 G protein subunit alpha i2 decreases expression ISO Caffeine results in decreased expression of GNAI2 protein CTD PMID:15708489 NCBI chr 3:50,227,068...50,259,362
Ensembl chr 3:50,226,292...50,259,362
JBrowse link
G GNAL G protein subunit alpha L increases response to substance ISO GNAL protein results in increased susceptibility to Caffeine CTD PMID:11404425 NCBI chr18:11,689,015...11,885,685
Ensembl chr18:11,689,264...11,885,685
JBrowse link
G GNAQ G protein subunit alpha q decreases expression ISO Caffeine results in decreased expression of GNAQ protein CTD PMID:15998294 NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811
JBrowse link
G GNAS GNAS complex locus decreases expression ISO Caffeine results in decreased expression of GNAS protein CTD PMID:15708489 NCBI chr20:58,839,681...58,911,192
Ensembl chr20:58,839,718...58,911,192
JBrowse link
G GOLT1B golgi transport 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr12:21,501,176...21,518,408
Ensembl chr12:21,501,781...21,518,408
JBrowse link
G GOSR1 golgi SNAP receptor complex member 1 decreases expression ISO Caffeine results in decreased expression of GOSR1 mRNA CTD PMID:20864626 NCBI chr17:30,477,402...30,527,592
Ensembl chr17:30,477,362...30,527,592
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 decreases expression EXP Caffeine results in decreased expression of GOT2 protein CTD PMID:31195006 NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342
JBrowse link
G GPC3 glypican 3 affects expression ISO Caffeine affects the expression of GPC3 mRNA CTD PMID:20864626 NCBI chr  X:133,535,745...133,985,616
Ensembl chr  X:133,535,745...133,985,594
Ensembl chr  X:133,535,745...133,985,594
JBrowse link
G GPI glucose-6-phosphate isomerase decreases expression EXP Caffeine results in decreased expression of GPI protein CTD PMID:31195006 NCBI chr19:34,353,330...34,402,413
Ensembl chr19:34,359,480...34,402,413
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions
increases activity
ISO Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]; fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Caffeine results in increased activity of GPT protein
CTD PMID:11394713, PMID:30776459 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Caffeine promotes the reaction [bisphenol A results in decreased expression of GPX1 mRNA] CTD PMID:31756439 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GPX3 glutathione peroxidase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GPX4 glutathione peroxidase 4 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA CTD PMID:31756439 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G GRID2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:92,303,622...93,810,415
Ensembl chr 4:92,303,966...93,810,157
JBrowse link
G GRM1 glutamate metabotropic receptor 1 decreases expression ISO Caffeine results in decreased expression of GRM1 protein CTD PMID:15998294 NCBI chr 6:146,027,634...146,437,601
Ensembl chr 6:146,027,646...146,437,601
JBrowse link
G GRPR gastrin releasing peptide receptor decreases expression ISO Caffeine results in decreased expression of GRPR mRNA CTD PMID:20864626 NCBI chr  X:16,123,565...16,153,518
Ensembl chr  X:16,123,565...16,153,518
JBrowse link
G GRWD1 glutamate rich WD repeat containing 1 decreases expression ISO Caffeine results in decreased expression of GRWD1 mRNA CTD PMID:20864626 NCBI chr19:48,445,983...48,457,022
Ensembl chr19:48,445,841...48,457,022
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha increases expression ISO Caffeine results in increased expression of GSK3A mRNA CTD PMID:25868845 NCBI chr19:42,230,186...42,243,330
Ensembl chr19:42,230,190...42,242,625
JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases phosphorylation
decreases phosphorylation
multiple interactions
EXP
ISO
Caffeine results in increased phosphorylation of GSK3B protein
Caffeine results in decreased phosphorylation of GSK3B protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein]
CTD PMID:15126379, PMID:21229324 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Caffeine results in decreased expression of GSTO1 mRNA CTD PMID:11793227 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
JBrowse link
G H1-0 H1.0 linker histone decreases expression EXP Caffeine results in decreased expression of H1F0 protein CTD PMID:31195006 NCBI chr22:37,805,229...37,807,432
Ensembl chr22:37,805,093...37,807,436
JBrowse link
G H1-4 H1.4 linker histone, cluster member increases expression EXP Caffeine results in increased expression of H1-4 protein CTD PMID:31195006 NCBI chr 6:26,156,329...26,157,115
Ensembl chr 6:26,156,354...26,157,107
Ensembl chr 6:26,156,354...26,157,107
JBrowse link
G H1-5 H1.5 linker histone, cluster member increases expression EXP Caffeine results in increased expression of H1-5 protein CTD PMID:31195006 NCBI chr 6:27,866,792...27,867,588
Ensembl chr 6:27,866,849...27,867,529
Ensembl chr 6:27,866,849...27,867,529
JBrowse link
G H1-6 H1.6 linker histone, cluster member increases expression EXP Caffeine results in increased expression of H1-6 protein CTD PMID:31195006 NCBI chr 6:26,107,412...26,108,135
Ensembl chr 6:26,107,419...26,108,136
Ensembl chr 6:26,107,419...26,108,136
JBrowse link
G H2AX H2A.X variant histone multiple interactions EXP
ISO
Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein]; Caffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]
[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein
CTD PMID:15537744, PMID:15975956, PMID:16777994, PMID:20888899, PMID:24069304, PMID:26231820 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G H4C9 H4 clustered histone 9 increases expression EXP Caffeine results in increased expression of H4C9 protein CTD PMID:31195006 NCBI chr 6:27,139,282...27,139,678
Ensembl chr 6:27,138,588...27,139,881
JBrowse link
G HACD1 3-hydroxyacyl-CoA dehydratase 1 decreases expression ISO Caffeine results in decreased expression of HACD1 mRNA CTD PMID:20864626 NCBI chr10:17,589,032...17,617,374
Ensembl chr10:17,589,032...17,617,374
JBrowse link
G HBA2 hemoglobin subunit alpha 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr16:172,876...173,710
Ensembl chr16:172,876...173,710
JBrowse link
G HDAC1 histone deacetylase 1 increases expression ISO Caffeine results in increased expression of HDAC1 mRNA CTD PMID:24717552 NCBI chr 1:32,292,083...32,333,628
Ensembl chr 1:32,292,083...32,333,635
JBrowse link
G HDAC2 histone deacetylase 2 increases expression ISO Caffeine results in increased expression of HDAC2 mRNA CTD PMID:24717552 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
JBrowse link
G HDAC7 histone deacetylase 7 increases expression ISO Caffeine results in increased expression of HDAC7 mRNA; Caffeine results in increased expression of HDAC7 protein CTD PMID:31306741 NCBI chr12:47,782,722...47,820,612
Ensembl chr12:47,782,722...47,833,132
JBrowse link
G HDLBP high density lipoprotein binding protein decreases expression ISO Caffeine results in decreased expression of HDLBP mRNA CTD PMID:25868845 NCBI chr 2:241,227,264...241,315,842
Ensembl chr 2:241,227,264...241,317,061
JBrowse link
G HECA hdc homolog, cell cycle regulator increases expression ISO Caffeine results in increased expression of HECA mRNA CTD PMID:20864626 NCBI chr 6:139,135,080...139,180,802
Ensembl chr 6:139,135,080...139,180,802
JBrowse link
G HELLS helicase, lymphoid specific multiple interactions
increases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]
Caffeine results in increased expression of HELLS protein
CTD PMID:20025956, PMID:20230807 NCBI chr10:94,545,778...94,613,905
Ensembl chr10:94,501,434...94,613,905
JBrowse link
G HHIPL2 HHIP like 2 decreases expression EXP Caffeine results in decreased expression of HHIPL2 protein CTD PMID:31195006 NCBI chr 1:222,501,521...222,548,104
Ensembl chr 1:222,522,258...222,548,104
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of HIF1A mRNA CTD PMID:31756439 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HINT1 histidine triad nucleotide binding protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA] CTD PMID:20230807 NCBI chr 5:131,159,027...131,165,256
Ensembl chr 5:131,155,383...131,224,468
Ensembl chr 5:131,155,383...131,224,468
JBrowse link
G HMGA1 high mobility group AT-hook 1 decreases expression EXP Caffeine results in decreased expression of HMGA1 protein CTD PMID:31195006 NCBI chr 6:34,236,873...34,246,231
Ensembl chr 6:34,236,873...34,246,231
JBrowse link
G HMGA2 high mobility group AT-hook 2 decreases expression EXP Caffeine results in decreased expression of HMGA2 protein CTD PMID:31195006 NCBI chr12:65,824,460...65,966,291
Ensembl chr12:65,824,460...65,966,291
Ensembl chr12:65,824,460...65,966,291
JBrowse link
G HMGB1 high mobility group box 1 decreases expression EXP Caffeine results in decreased expression of HMGB1 protein CTD PMID:31195006 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
ISO
EXP
[Dietary Fats co-treated with Caffeine] results in decreased expression of HMGCR mRNA; Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA]
Caffeine results in increased expression of HMGCR mRNA; Caffeine results in increased expression of HMGCR protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]
CTD PMID:29800656, PMID:29958987, PMID:30825513 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression
multiple interactions
increases expression
ISO
EXP
Caffeine results in decreased expression of HMGCS1 mRNA
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]
CTD PMID:20864626, PMID:25868845, PMID:30825513 NCBI chr 5:43,287,470...43,313,477
Ensembl chr 5:43,287,470...43,313,512
JBrowse link
G HMSD histocompatibility minor serpin domain containing decreases expression EXP Caffeine results in decreased expression of HMSD protein CTD PMID:31195006 NCBI chr18:63,949,259...63,969,329
Ensembl chr18:63,949,301...63,981,774
JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 decreases expression EXP Caffeine results in decreased expression of HNRNPA1 protein CTD PMID:31195006 NCBI chr12:54,280,726...54,287,087
Ensembl chr12:54,280,193...54,287,088
JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HNRNPC mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr14:21,209,147...21,269,442
Ensembl chr14:21,209,136...21,269,494
JBrowse link
G HNRNPDL heterogeneous nuclear ribonucleoprotein D like decreases expression EXP Caffeine results in decreased expression of HNRNPDL protein CTD PMID:31195006 NCBI chr 4:82,422,564...82,430,462
Ensembl chr 4:82,422,564...82,430,408
JBrowse link
G HNRNPF heterogeneous nuclear ribonucleoprotein F decreases expression EXP Caffeine results in decreased expression of HNRNPF protein CTD PMID:31195006 NCBI chr10:43,385,618...43,409,186
Ensembl chr10:43,385,617...43,409,166
JBrowse link
G HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 decreases expression EXP Caffeine results in decreased expression of HNRNPH1 protein CTD PMID:31195006 NCBI chr 5:179,614,178...179,634,784
Ensembl chr 5:179,614,178...179,634,784
JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression
ISO
EXP
Caffeine results in decreased expression of HNRNPK mRNA
Caffeine results in increased expression of HNRNPK protein
CTD PMID:25868845, PMID:31195006 NCBI chr 9:83,968,083...83,980,630
Ensembl chr 9:83,968,083...83,980,616
JBrowse link
G HOMER1 homer scaffold protein 1 multiple interactions ISO HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134
JBrowse link
G HOXB7 homeobox B7 increases expression EXP Caffeine results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr17:48,607,232...48,611,017
Ensembl chr17:48,607,232...48,633,572
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO Caffeine results in increased expression of HPRT1 protein CTD PMID:6149265 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
G HRAS HRas proto-oncogene, GTPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA] CTD PMID:20230807 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,287
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 increases expression ISO Caffeine results in increased expression of HSD11B1 mRNA CTD PMID:22583948, PMID:30423288, PMID:30528684 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
multiple interactions
ISO
EXP
Caffeine results in decreased expression of HSD11B2 mRNA
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
CTD PMID:22583948, PMID:22701600, PMID:30423288, PMID:30528684 NCBI chr16:67,431,121...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 decreases expression ISO Caffeine results in decreased expression of HSD17B7 mRNA CTD PMID:20864626 NCBI chr 1:162,790,702...162,812,823
Ensembl chr 1:162,790,702...162,812,817
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression
decreases expression
ISO Caffeine results in increased expression of HSD3B1 mRNA
Caffeine results in decreased expression of HSD3B1 mRNA
CTD PMID:25868845, PMID:30528684 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA] CTD PMID:20230807 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,738...102,139,699
Ensembl chr14:102,080,738...102,139,699
JBrowse link
G HSP90AA2P heat shock protein 90 alpha family class A member 2, pseudogene increases expression EXP Caffeine results in increased expression of HSP90AA2P protein CTD PMID:31195006 NCBI chr11:27,888,171...27,891,092
Ensembl chr11:27,888,838...27,891,033
JBrowse link
G HSP90AB2P heat shock protein 90 alpha family class B member 2, pseudogene decreases expression EXP Caffeine results in decreased expression of HSP90AB2P protein CTD PMID:31195006 NCBI chr 4:13,336,387...13,338,931
Ensembl chr 4:13,333,414...13,338,657
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression ISO Caffeine results in decreased expression of HSP90B1 mRNA CTD PMID:25868845 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,645
JBrowse link
G HSP90B2P heat shock protein 90 beta family member 2, pseudogene decreases expression EXP Caffeine results in decreased expression of HSP90B2P protein CTD PMID:31195006 NCBI chr15:99,257,525...99,260,276
Ensembl chr15:99,257,632...99,260,015
JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 increases expression EXP Caffeine results in increased expression of HSPA4 protein CTD PMID:31195006 NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449
JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 decreases expression EXP Caffeine results in decreased expression of HSPA9 protein CTD PMID:31195006 NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,416
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 increases expression
decreases expression
ISO
EXP
Caffeine results in increased expression of HSPB1 mRNA
Caffeine results in decreased expression of HSPB1 protein
CTD PMID:20864626, PMID:31195006 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G HSPB6 heat shock protein family B (small) member 6 increases expression ISO Caffeine results in increased expression of HSPB6 mRNA CTD PMID:20864626 NCBI chr19:35,754,566...35,757,029
Ensembl chr19:35,754,566...35,758,079
JBrowse link
G HSPE1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 2:197,500,379...197,503,449
Ensembl chr 2:197,500,140...197,503,449
JBrowse link
G IBSP integrin binding sialoprotein decreases expression ISO Caffeine results in decreased expression of IBSP mRNA CTD PMID:31874197 NCBI chr 4:87,799,554...87,812,435
Ensembl chr 4:87,799,554...87,812,435
JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression EXP Caffeine results in decreased expression of ICAM1 mRNA CTD PMID:28089782 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G ID3 inhibitor of DNA binding 3, HLH protein increases expression ISO Caffeine results in increased expression of ID3 mRNA CTD PMID:20864626 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Caffeine results in decreased expression of IDI1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr10:1,039,152...1,056,704
Ensembl chr10:1,039,152...1,049,170
JBrowse link
G IGF1 insulin like growth factor 1 decreases secretion
multiple interactions
affects expression
decreases activity
decreases expression
ISO Caffeine results in decreased secretion of IGF1 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of IGF1 mRNA
Caffeine affects the expression of IGF1 protein
Caffeine results in decreased activity of IGF1 protein
Caffeine results in decreased expression of IGF1 mRNA; Caffeine results in decreased expression of IGF1 protein
CTD PMID:1995187, PMID:22583948, PMID:24239806, PMID:29343424, PMID:29966748, PMID:30528684, PMID:31756439 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGF1R insulin like growth factor 1 receptor decreases expression
affects expression
ISO Caffeine results in decreased expression of IGF1R mRNA; Caffeine results in decreased expression of IGF1R protein
Caffeine affects the expression of IGF1R mRNA
CTD PMID:22583948, PMID:29343424, PMID:29966748, PMID:30528684 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IGFBP1 insulin like growth factor binding protein 1 increases expression EXP Caffeine results in increased expression of IGFBP1 mRNA CTD PMID:11793227 NCBI chr 7:45,888,488...45,893,660
Ensembl chr 7:45,888,360...45,893,660
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta increases expression ISO Caffeine results in increased expression of IKBKB mRNA CTD PMID:20864626 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL10 interleukin 10 increases expression EXP Caffeine results in increased expression of IL10 mRNA CTD PMID:28089782 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL10RB interleukin 10 receptor subunit beta increases expression ISO Caffeine results in increased expression of IL10RB mRNA CTD PMID:20864626 NCBI chr21:33,266,367...33,297,221
Ensembl chr21:33,266,367...33,310,187
JBrowse link
G IL12A interleukin 12A decreases expression EXP Caffeine results in decreased expression of IL12A mRNA CTD PMID:28089782 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019
JBrowse link
G IL12B interleukin 12B multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] CTD PMID:26852703 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,487
JBrowse link
G IL1B interleukin 1 beta decreases expression
increases expression
EXP
ISO
Caffeine results in decreased expression of IL1B mRNA
Caffeine results in increased expression of IL1B mRNA
CTD PMID:28089782, PMID:29055810, PMID:30776459 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RL1 interleukin 1 receptor like 1 increases expression ISO Caffeine results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 2:102,311,529...102,352,367
Ensembl chr 2:102,311,502...102,352,037
JBrowse link
G IL3 interleukin 3 multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA] CTD PMID:26852703 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204
JBrowse link
G IL4R interleukin 4 receptor increases expression
multiple interactions
ISO Caffeine results in increased expression of IL4RA mRNA
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IL4RA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA]
CTD PMID:20230807, PMID:20864626 NCBI chr16:27,313,668...27,364,778
Ensembl chr16:27,313,668...27,364,778
JBrowse link
G IL5 interleukin 5 increases expression EXP Caffeine results in increased expression of IL5 mRNA CTD PMID:28089782 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G IL6 interleukin 6 decreases expression
increases expression
multiple interactions
ISO Caffeine results in decreased expression of IL6 mRNA
Caffeine results in increased expression of IL6 mRNA
Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]
CTD PMID:23727198, PMID:26852703, PMID:29055810, PMID:30776459 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ILF3 interleukin enhancer binding factor 3 increases expression EXP Caffeine results in increased expression of ILF3 protein CTD PMID:31195006 NCBI chr19:10,654,295...10,692,400
Ensembl chr19:10,654,261...10,692,417
JBrowse link
G IMPDH2 inosine monophosphate dehydrogenase 2 decreases expression EXP Caffeine results in decreased expression of IMPDH2 protein CTD PMID:31195006 NCBI chr 3:49,024,325...49,029,750
Ensembl chr 3:49,024,325...49,029,408
JBrowse link
G INO80C INO80 complex subunit C decreases expression ISO Caffeine results in decreased expression of INO80C mRNA CTD PMID:20864626 NCBI chr18:35,468,333...35,497,960
Ensembl chr18:35,452,230...35,497,979
Ensembl chr18:35,452,230...35,497,979
JBrowse link
G INS insulin multiple interactions EXP Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:21081844 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G INSIG1 insulin induced gene 1 decreases expression ISO Caffeine results in decreased expression of INSIG1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr 7:155,297,878...155,310,235
Ensembl chr 7:155,297,776...155,310,235
JBrowse link
G INSR insulin receptor decreases expression ISO Caffeine results in decreased expression of INSR mRNA CTD PMID:22583948 NCBI chr19:7,112,257...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:154,010,507...154,019,984
Ensembl chr  X:154,010,506...154,019,902
JBrowse link
G IRX3 iroquois homeobox 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr16:54,283,304...54,286,787
Ensembl chr16:54,283,304...54,286,787
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions ISO Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITGAM protein] CTD PMID:19882200 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G ITM2B integral membrane protein 2B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr13:48,233,206...48,270,357
Ensembl chr13:48,232,612...48,270,357
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 decreases expression EXP Caffeine results in decreased expression of ITPR1 mRNA CTD PMID:18444173 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,840
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation
increases expression
ISO Caffeine results in decreased phosphorylation of JUN protein
Caffeine results in increased expression of JUN protein
CTD PMID:17145898, PMID:20025956 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KCTD14 potassium channel tetramerization domain containing 14 decreases expression ISO Caffeine results in decreased expression of KCTD14 mRNA CTD PMID:20864626 NCBI chr11:78,015,715...78,046,191
Ensembl chr11:78,015,715...78,046,191
JBrowse link
G KHSRP KH-type splicing regulatory protein increases expression EXP Caffeine results in increased expression of KHSRP protein CTD PMID:31195006 NCBI chr19:6,413,102...6,424,811
Ensembl chr19:6,413,348...6,424,794
JBrowse link
G KIDINS220 kinase D interacting substrate 220 increases expression ISO Caffeine results in increased expression of KIDINS220 mRNA CTD PMID:20864626 NCBI chr 2:8,721,081...8,837,613
Ensembl chr 2:8,721,081...8,837,630
JBrowse link
G KIF3B kinesin family member 3B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KIF3B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr20:32,277,651...32,335,011
Ensembl chr20:32,277,651...32,335,011
JBrowse link
G KLF4 Kruppel like factor 4 multiple interactions
decreases expression
ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Caffeine results in decreased expression of KLF4 mRNA; Caffeine results in decreased expression of KLF4 protein
CTD PMID:20230807, PMID:31306741 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482
JBrowse link
G KRT1 keratin 1 decreases expression EXP Caffeine results in decreased expression of KRT1 protein CTD PMID:31195006 NCBI chr12:52,674,736...52,680,407
Ensembl chr12:52,674,736...52,680,407
JBrowse link
G KRT18 keratin 18 decreases expression EXP Caffeine results in decreased expression of KRT18 protein CTD PMID:31195006 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G KRT36 keratin 36 decreases expression EXP Caffeine results in decreased expression of KRT36 protein CTD PMID:31195006 NCBI chr17:41,486,136...41,489,910
Ensembl chr17:41,486,136...41,492,546
JBrowse link
G KRT84 keratin 84 decreases expression EXP Caffeine results in decreased expression of KRT84 protein CTD PMID:31195006 NCBI chr12:52,377,665...52,386,977
Ensembl chr12:52,377,812...52,385,652
JBrowse link
G LAMB1 laminin subunit beta 1 increases expression EXP Caffeine results in increased expression of LAMB1 protein CTD PMID:31195006 NCBI chr 7:107,923,799...108,003,176
Ensembl chr 7:107,923,799...108,003,187
JBrowse link
G LDHA lactate dehydrogenase A decreases expression EXP Caffeine results in decreased expression of LDHA mRNA CTD PMID:11793227 NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions ISO [Caffeine co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; Caffeine promotes the reaction [Dietary Fats results in decreased expression of LDLR mRNA] CTD PMID:29800656 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G LEP leptin decreases expression
multiple interactions
ISO
EXP
Caffeine results in decreased expression of LEP mRNA
Caffeine results in decreased expression of LEP mRNA; Caffeine results in decreased expression of LEP protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]
CTD PMID:23727198, PMID:26367767 NCBI chr 7:128,241,201...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LEPR leptin receptor increases expression
decreases expression
ISO Caffeine results in increased expression of LEPR mRNA
Caffeine results in decreased expression of LEPR mRNA
CTD PMID:22583948, PMID:26367767 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LMNB1 lamin B1 decreases expression EXP Caffeine results in decreased expression of LMNB1 protein CTD PMID:31195006 NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020
JBrowse link
G LPAR4 lysophosphatidic acid receptor 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:78,747,658...78,758,714
Ensembl chr  X:78,747,709...78,757,094
JBrowse link
G LPL lipoprotein lipase decreases expression
multiple interactions
ISO Caffeine results in decreased expression of LPL mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA
CTD PMID:23727198, PMID:28843594 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G LSS lanosterol synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824
JBrowse link
G LYSMD2 LysM domain containing 2 decreases expression ISO Caffeine results in decreased expression of LYSMD2 mRNA CTD PMID:20864626 NCBI chr15:51,723,011...51,751,451
Ensembl chr15:51,723,011...51,751,585
JBrowse link
G MAEL maelstrom spermatogenic transposon silencer decreases expression EXP Caffeine results in decreased expression of MAEL protein CTD PMID:31195006 NCBI chr 1:166,921,121...167,022,214
Ensembl chr 1:166,975,582...167,022,214
JBrowse link
G MAOA monoamine oxidase A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta increases cleavage
multiple interactions
ISO
EXP
Caffeine results in increased cleavage of MAP1LC3B protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
CTD PMID:30555576 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAP2K7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr19:7,903,785...7,914,478
Ensembl chr19:7,903,843...7,914,478
JBrowse link
G MAP3K12 mitogen-activated protein kinase kinase kinase 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP3K12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP3K12 mRNA] CTD PMID:20230807 NCBI chr12:53,479,669...53,501,205
Ensembl chr12:53,479,669...53,500,063
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases expression
multiple interactions
decreases phosphorylation
EXP
ISO
Caffeine results in increased expression of MAPK1 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Caffeine results in decreased phosphorylation of MAPK1 protein
CTD PMID:17145898, PMID:21081844, PMID:22974838 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK15 mitogen-activated protein kinase 15 increases expression ISO Caffeine results in increased expression of MAPK15 mRNA CTD PMID:20864626 NCBI chr 8:143,716,305...143,722,458
Ensembl chr 8:143,716,340...143,722,458
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases expression
multiple interactions
decreases phosphorylation
EXP
ISO
Caffeine results in increased expression of MAPK3 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Caffeine results in decreased phosphorylation of MAPK3 protein
CTD PMID:17145898, PMID:21081844, PMID:22974838 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MARCHF11 membrane associated ring-CH-type finger 11 decreases expression ISO Caffeine results in decreased expression of MARCHF11 mRNA CTD PMID:20864626 NCBI chr 5:16,067,139...16,179,791
Ensembl chr 5:16,067,139...16,180,762
JBrowse link
G MC2R melanocortin 2 receptor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MC2R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MC2R mRNA] CTD PMID:20230807 NCBI chr18:13,882,042...13,915,707
Ensembl chr18:13,882,044...13,915,707
JBrowse link
G MCM3 minichromosome maintenance complex component 3 increases expression ISO Caffeine results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 6:52,264,015...52,284,742
Ensembl chr 6:52,264,014...52,284,881
JBrowse link
G MDH2 malate dehydrogenase 2 decreases expression EXP Caffeine results in decreased expression of MDH2 protein CTD PMID:31195006 NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508
JBrowse link
G MEF2A myocyte enhancer factor 2A increases expression
multiple interactions
ISO Caffeine results in increased expression of MEF2A mRNA; Caffeine results in increased expression of MEF2A protein
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]
CTD PMID:25093688 NCBI chr15:99,565,417...99,716,488
Ensembl chr15:99,565,417...99,716,466
JBrowse link
G MEF2C myocyte enhancer factor 2C multiple interactions
increases expression
ISO Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]
Caffeine results in increased expression of MEF2C mRNA; Caffeine results in increased expression of MEF2C protein
CTD PMID:25093688 NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases expression EXP Caffeine results in decreased expression of MGST1 mRNA CTD PMID:11793227 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MICA MHC class I polypeptide-related sequence A multiple interactions EXP Caffeine inhibits the reaction [resveratrol results in increased expression of MICA protein] CTD PMID:23445485 NCBI chr 6:31,400,711...31,415,315
Ensembl chr 6:31,399,784...31,415,315
JBrowse link
G MICB MHC class I polypeptide-related sequence B multiple interactions EXP Caffeine inhibits the reaction [[decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein] CTD PMID:18395517 NCBI chr 6:31,494,918...31,511,124
Ensembl chr 6:31,494,881...31,511,124
JBrowse link
G MIR101-1 microRNA 101-1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 1:65,058,434...65,058,508
Ensembl chr 1:65,058,434...65,058,508
JBrowse link
G MIR122 microRNA 122 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:58,451,074...58,451,158
Ensembl chr18:58,451,074...58,451,158
JBrowse link
G MIR192 microRNA 192 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr11:64,891,137...64,891,246
Ensembl chr11:64,891,137...64,891,246
JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions
decreases expression
ISO Caffeine inhibits the reaction [aluminum chloride results in decreased expression of MKI67 protein]
Caffeine results in decreased expression of MKI67 protein
CTD PMID:26339337, PMID:30528684 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G MLXIPL MLX interacting protein like multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr 7:73,593,201...73,624,522
Ensembl chr 7:73,593,194...73,624,543
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression ISO Caffeine results in increased expression of MMP13 mRNA CTD PMID:31874197 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP7 matrix metallopeptidase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA] CTD PMID:20230807 NCBI chr11:102,520,508...102,530,747
Ensembl chr11:102,520,508...102,530,750
JBrowse link
G MOGAT1 monoacylglycerol O-acyltransferase 1 decreases expression ISO Caffeine results in decreased expression of MOGAT1 mRNA CTD PMID:20864626 NCBI chr 2:222,671,658...222,709,930
Ensembl chr 2:222,671,658...222,709,930
JBrowse link
G MOS MOS proto-oncogene, serine/threonine kinase increases expression EXP Caffeine results in increased expression of MOS protein CTD PMID:31195006 NCBI chr 8:56,112,942...56,113,982
Ensembl chr 8:56,112,942...56,113,982
JBrowse link
G MRM3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Caffeine results in decreased expression of MRM3 mRNA CTD PMID:20864626 NCBI chr17:782,353...792,509
Ensembl chr17:782,353...792,509
JBrowse link
G MRPL19 mitochondrial ribosomal protein L19 decreases expression ISO Caffeine results in decreased expression of MRPL19 mRNA CTD PMID:20864626 NCBI chr 2:75,646,783...75,662,206
Ensembl chr 2:75,646,783...75,690,851
JBrowse link
G MRPL20 mitochondrial ribosomal protein L20 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 1:1,401,909...1,407,293
Ensembl chr 1:1,401,909...1,407,293
JBrowse link
G MRPL9 mitochondrial ribosomal protein L9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 1:151,759,647...151,763,496
Ensembl chr 1:151,759,647...151,763,496
JBrowse link
G MRPS5 mitochondrial ribosomal protein S5 increases expression EXP Caffeine results in increased expression of MRPS5 protein CTD PMID:31195006 NCBI chr 2:95,085,369...95,122,003
Ensembl chr 2:95,085,369...95,149,434
JBrowse link
G MSH2 mutS homolog 2 decreases expression ISO Caffeine results in decreased expression of MSH2 mRNA CTD PMID:12706856 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSMO1 methylsterol monooxygenase 1 decreases expression ISO Caffeine results in decreased expression of MSMO1 mRNA CTD PMID:20864626, PMID:25868845 NCBI chr 4:165,327,669...165,343,164
Ensembl chr 4:165,327,667...165,343,164
JBrowse link
G MT1G metallothionein 1G increases expression EXP Caffeine results in increased expression of MT1G mRNA CTD PMID:11793227 NCBI chr16:56,666,730...56,668,065
Ensembl chr16:56,666,731...56,668,065
Ensembl chr16:56,666,731...56,668,065
JBrowse link
G MT2A metallothionein 2A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MTCH1 mitochondrial carrier 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTCH1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr 6:36,968,135...36,987,171
Ensembl chr 6:36,968,141...36,986,298
JBrowse link
G MTF2 metal response element binding transcription factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr 1:93,079,283...93,139,076
Ensembl chr 1:93,079,235...93,139,079
JBrowse link
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like decreases expression ISO Caffeine results in decreased expression of MTHFD2L mRNA CTD PMID:20864626 NCBI chr 4:74,123,273...74,303,099
Ensembl chr 4:74,114,174...74,303,099
JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases activity EXP Caffeine results in decreased activity of MTOR protein CTD PMID:21081844 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase decreases expression ISO Caffeine results in decreased expression of MTRR mRNA CTD PMID:20864626 NCBI chr 5:7,851,186...7,901,124
Ensembl chr 5:7,851,186...7,906,025
JBrowse link
G MUTYH mutY DNA glycosylase increases expression ISO Caffeine results in increased expression of MUTYH mRNA CTD PMID:20864626 NCBI chr 1:45,329,242...45,340,447
Ensembl chr 1:45,329,163...45,340,893
JBrowse link
G MVD mevalonate diphosphate decarboxylase decreases expression ISO Caffeine results in decreased expression of MVD mRNA CTD PMID:25868845 NCBI chr16:88,651,935...88,663,153
Ensembl chr16:88,651,935...88,663,161
JBrowse link
G MVK mevalonate kinase increases expression ISO Caffeine results in increased expression of MVK mRNA CTD PMID:25868845 NCBI chr12:109,573,461...109,598,125
Ensembl chr12:109,573,255...109,598,125
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA] CTD PMID:18283038 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYH7 myosin heavy chain 7 increases expression
multiple interactions
ISO Caffeine results in increased expression of MYH7 mRNA
Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; Cyclosporine inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]
CTD PMID:25093688 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G MYL6B myosin light chain 6B decreases expression EXP Caffeine results in decreased expression of MYL6B protein CTD PMID:31195006 NCBI chr12:56,152,587...56,157,982
Ensembl chr12:56,152,256...56,159,647
JBrowse link
G MYOF myoferlin increases expression EXP Caffeine results in increased expression of MYOF protein CTD PMID:31195006 NCBI chr10:93,306,429...93,482,505
Ensembl chr10:93,306,429...93,482,334
JBrowse link
G NAT2 N-acetyltransferase 2 increases acetylation
affects metabolic processing
EXP NAT2 protein results in increased acetylation of Caffeine
NAT2 gene polymorphism affects the metabolism of Caffeine; NAT2 protein affects the metabolism of Caffeine
CTD PMID:14586384, PMID:14586387, PMID:14747882, PMID:15199075, PMID:15327588, PMID:15558239, PMID:15980104, PMID:24221535 NCBI chr 8:18,386,585...18,401,219
Ensembl chr 8:18,391,282...18,401,218
JBrowse link
G NCL nucleolin increases expression EXP Caffeine results in increased expression of NCL protein CTD PMID:31195006 NCBI chr 2:231,453,531...231,464,484
Ensembl chr 2:231,453,531...231,483,641
JBrowse link
G NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NDUFB5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 3:179,604,794...179,627,647
Ensembl chr 3:179,604,690...179,627,647
JBrowse link
G NDUFS4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFS4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFS4 mRNA] CTD PMID:20230807 NCBI chr 5:53,560,610...53,683,338
Ensembl chr 5:53,560,633...53,683,338
JBrowse link
G NEFH neurofilament heavy affects expression ISO Caffeine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390
JBrowse link
G NEUROG2 neurogenin 2 increases expression EXP Caffeine results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 4:112,513,516...112,516,180
Ensembl chr 4:112,513,516...112,516,180
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:22974838 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] CTD PMID:26852703 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NISCH nischarin multiple interactions ISO Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr 3:52,455,603...52,493,068
Ensembl chr 3:52,455,118...52,493,068
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22974838, PMID:26852703 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO [Isoproterenol co-treated with Caffeine] results in decreased expression of NOS3 mRNA CTD PMID:29447158 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
G NPHS2 NPHS2 stomatin family member, podocin decreases expression ISO Caffeine results in decreased expression of NPHS2 mRNA CTD PMID:25986755, PMID:31306741 NCBI chr 1:179,550,539...179,575,987
Ensembl chr 1:179,550,539...179,575,952
JBrowse link
G NPL N-acetylneuraminate pyruvate lyase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr 1:182,789,773...182,830,384
Ensembl chr 1:182,789,293...182,830,384
JBrowse link
G NPPA natriuretic peptide A multiple interactions
increases expression
ISO Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] CTD PMID:15452191, PMID:25093688 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPPB natriuretic peptide B increases expression
multiple interactions
ISO Caffeine results in increased expression of NPPB mRNA
Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]
CTD PMID:25093688 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 increases expression ISO Caffeine results in increased expression of NR3C1 mRNA; Caffeine results in increased expression of NR3C1 protein CTD PMID:22583948, PMID:30423288, PMID:30528684, PMID:30776459, PMID:31306741, PMID:32663519 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 increases expression ISO Caffeine results in increased expression of NR3C2 mRNA CTD PMID:22959462 NCBI chr 4:148,078,764...148,444,698
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G NR5A1 nuclear receptor subfamily 5 group A member 1 increases methylation
decreases expression
ISO Caffeine results in increased methylation of NR5A1 promoter
Caffeine results in decreased expression of NR5A1 mRNA; Caffeine results in decreased expression of NR5A1 protein
CTD PMID:24717552 NCBI chr 9:124,481,236...124,507,399
Ensembl chr 9:124,481,236...124,507,420
JBrowse link
G NRF1 nuclear respiratory factor 1 decreases expression ISO Caffeine results in decreased expression of NRF1 mRNA CTD PMID:20864626 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082
JBrowse link
G NSF N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr17:46,590,669...46,757,464
Ensembl chr17:46,590,669...46,757,464
JBrowse link
G NT5E 5'-nucleotidase ecto decreases activity
multiple interactions
ISO Caffeine results in decreased activity of NT5E protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]
CTD PMID:28465162 NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G OAT ornithine aminotransferase increases expression EXP Caffeine results in increased expression of OAT mRNA CTD PMID:11793227 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976
JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 increases expression EXP Caffeine results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394
JBrowse link
G ORM1 orosomucoid 1 increases expression ISO Caffeine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,056...114,326,475
JBrowse link
G ORM2 orosomucoid 2 increases expression ISO Caffeine results in increased expression of ORM2 protein CTD PMID:20025956 NCBI chr 9:114,329,869...114,333,251
Ensembl chr 9:114,329,869...114,333,251
Ensembl chr 9:114,329,869...114,333,251
JBrowse link
G OXSR1 oxidative stress responsive kinase 1 increases expression ISO Caffeine results in increased expression of OXSR1 mRNA CTD PMID:20864626 NCBI chr 3:38,165,051...38,255,486
Ensembl chr 3:38,165,089...38,255,484
JBrowse link
G P3H3 prolyl 3-hydroxylase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of P3H3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr12:6,828,407...6,839,847
Ensembl chr12:6,828,407...6,839,847
JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 decreases expression ISO Caffeine results in decreased expression of PAK1 mRNA CTD PMID:29343424 NCBI chr11:77,322,017...77,514,957
Ensembl chr11:77,321,707...77,474,635
Ensembl chr11:77,321,707...77,474,635
JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 increases activity
multiple interactions
EXP
ISO
Caffeine results in increased activity of PAK2 protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]
CTD PMID:19325779, PMID:20230807 NCBI chr 3:196,739,857...196,832,647
Ensembl chr 3:196,739,857...196,832,647
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 affects cleavage
decreases response to substance
multiple interactions
increases cleavage
EXP
ISO
Caffeine affects the cleavage of PARP1 protein
PARP1 protein results in decreased susceptibility to Caffeine
Caffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; Caffeine results in increased cleavage of and results in increased expression of PARP1 protein
Caffeine results in increased cleavage of PARP1 protein
CTD PMID:16522534, PMID:19242509, PMID:19490937, PMID:21229324, PMID:21840268, PMID:22226932, PMID:30377735 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PAX3 paired box 3 decreases expression EXP Caffeine results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 2:222,199,887...222,298,998
Ensembl chr 2:222,199,888...222,298,996
Ensembl chr 2:222,199,888...222,298,996
JBrowse link
G PCARE photoreceptor cilium actin regulator decreases expression EXP Caffeine results in decreased expression of PCARE protein CTD PMID:31195006 NCBI chr 2:29,061,695...29,074,523
Ensembl chr 2:29,060,976...29,074,523
JBrowse link
G PCNA proliferating cell nuclear antigen affects expression ISO Caffeine affects the expression of PCNA mRNA; Caffeine affects the expression of PCNA protein CTD PMID:29343424 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO Caffeine results in decreased expression of PCSK9 mRNA CTD PMID:25868845 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852
Ensembl chr 1:55,039,447...55,064,852
JBrowse link
G PDE11A phosphodiesterase 11A decreases expression ISO Caffeine results in decreased expression of PDE11A mRNA CTD PMID:20864626 NCBI chr 2:177,623,244...178,108,339
Ensembl chr 2:177,628,069...178,108,339
Ensembl chr 2:177,628,069...178,108,339
JBrowse link
G PDE5A phosphodiesterase 5A decreases expression ISO Caffeine results in decreased expression of PDE5A mRNA CTD PMID:20864626 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804
JBrowse link
G PDHX pyruvate dehydrogenase complex component X decreases expression ISO Caffeine results in decreased expression of PDHX mRNA CTD PMID:20864626 NCBI chr11:34,915,829...34,996,128
Ensembl chr11:34,915,829...35,020,591
JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PDIA6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 2:10,783,391...10,837,712
Ensembl chr 2:10,783,391...10,837,977
JBrowse link
G PFDN1 prefoldin subunit 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr 5:140,245,035...140,303,101
Ensembl chr 5:140,245,035...140,303,113
JBrowse link
G PFKM phosphofructokinase, muscle affects expression EXP Caffeine affects the expression of PFKM protein CTD PMID:25486098 NCBI chr12:48,105,353...48,146,404
Ensembl chr12:48,105,139...48,146,404
JBrowse link
G PGK2 phosphoglycerate kinase 2 decreases expression EXP Caffeine results in decreased expression of PGK2 protein CTD PMID:31195006 NCBI chr 6:49,785,660...49,787,285
Ensembl chr 6:49,785,660...49,787,285
JBrowse link
G PGR progesterone receptor increases expression ISO Caffeine results in increased expression of PGR mRNA CTD PMID:20864626 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PHB prohibitin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA] CTD PMID:20230807 NCBI chr17:49,404,052...49,414,882
Ensembl chr17:49,404,049...49,414,905
JBrowse link
G PHEX phosphate regulating endopeptidase homolog X-linked increases expression ISO Caffeine results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:22,032,325...22,251,310
Ensembl chr  X:22,032,325...22,251,310
JBrowse link
G PHTF1 putative homeodomain transcription factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PHTF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA] CTD PMID:20230807 NCBI chr 1:113,696,831...113,759,888
Ensembl chr 1:113,696,831...113,759,489
JBrowse link
G PIDD1 p53-induced death domain protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr11:799,179...809,867
Ensembl chr11:799,179...809,753
JBrowse link
G PIGC phosphatidylinositol glycan anchor biosynthesis class C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr 1:172,441,457...172,444,069
Ensembl chr 1:172,370,189...172,444,086
JBrowse link
G PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr19:3,630,181...3,700,486
Ensembl chr19:3,630,183...3,700,479
Ensembl chr19:3,630,183...3,700,479
JBrowse link
G PITX2 paired like homeodomain 2 decreases expression ISO Caffeine results in decreased expression of PITX2 mRNA CTD PMID:20864626 NCBI chr 4:110,617,423...110,642,123
Ensembl chr 4:110,617,423...110,642,123
JBrowse link
G PKD1 polycystin 1, transient receptor potential channel interacting multiple interactions
affects response to substance
ISO PKD1 protein affects the reaction [Caffeine affects the abundance of Calcium]
PKD1 protein affects the susceptibility to Caffeine
CTD PMID:18679710 NCBI chr16:2,088,708...2,135,898
Ensembl chr16:2,088,708...2,135,898
Ensembl chr16:2,088,708...2,135,898
JBrowse link
G PLA2G12A phospholipase A2 group XIIA multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 4:109,709,989...109,730,070
Ensembl chr 4:109,709,989...109,730,070
JBrowse link
G PLCB1 phospholipase C beta 1 multiple interactions
decreases expression
ISO Caffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]
Caffeine results in decreased expression of PLCB1 protein
CTD PMID:15998294 NCBI chr20:8,132,266...8,884,900
Ensembl chr20:8,077,251...8,968,360
JBrowse link
G PLEC plectin decreases expression EXP Caffeine results in decreased expression of PLEC protein CTD PMID:31195006 NCBI chr 8:143,915,153...143,976,800
Ensembl chr 8:143,915,147...143,976,734
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G PLG plasminogen decreases expression ISO Caffeine results in decreased expression of PLG mRNA CTD PMID:25868845 NCBI chr 6:160,702,193...160,754,097
Ensembl chr 6:160,702,238...160,754,097
Ensembl chr 6:160,702,238...160,754,097
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G PLP1 proteolipid protein 1 increases expression EXP Caffeine results in increased expression of PLP1 mRNA CTD PMID:18444173 NCBI chr  X:103,776,506...103,792,619
Ensembl chr  X:103,773,718...103,792,619
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G PLS1 plastin 1 increases expression EXP Caffeine results in increased expression of PLS1 protein CTD PMID:31195006 NCBI chr 3:142,596,393...142,713,664
Ensembl chr 3:142,596,393...142,713,664
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G PLS3 plastin 3 decreases expression EXP Caffeine results in decreased expression of PLS3 protein CTD PMID:31195006 NCBI chr  X:115,561,174...115,650,861
Ensembl chr  X:115,561,174...115,650,861
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G PNP purine nucleoside phosphorylase increases expression ISO Caffeine results in increased expression of PNP protein CTD PMID:6149265 NCBI chr14:20,469,406...20,477,089
Ensembl chr14:20,468,954...20,477,094
Ensembl chr14:20,468,954...20,477,094
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G PNPLA8 patatin like phospholipase domain containing 8 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 7:108,470,417...108,528,178
Ensembl chr 7:108,470,417...108,569,666
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G POMC proopiomelanocortin increases secretion ISO Caffeine results in increased secretion of POMC protein alternative form CTD PMID:22959462 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
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G POTEE POTE ankyrin domain family member E decreases expression EXP Caffeine results in decreased expression of POTEE protein CTD PMID:31195006 NCBI chr 2:131,209,536...131,265,278
Ensembl chr 2:131,218,067...131,265,278
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G POTEI POTE ankyrin domain family member I decreases expression EXP Caffeine results in decreased expression of POTEI protein CTD PMID:31195006 NCBI chr 2:130,459,455...130,509,707
Ensembl chr 2:130,459,455...130,509,707
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G POTEKP POTE ankyrin domain family member K, pseudogene increases expression EXP Caffeine results in increased expression of POTEKP protein CTD PMID:31195006