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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diuretic
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Accession:CHEBI:35498 term browser browse the term
Definition:An agent that promotes the excretion of urine through its effects on kidney function.
Synonyms:related_synonym: diuretics


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D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Mannitol results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
spironolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator decreases expression EXP Spironolactone results in decreased expression of BAX protein CTD PMID:20082611 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Spironolactone results in increased expression of BCL2 protein CTD PMID:20082611 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
G CAPN1 calpain 1 decreases expression EXP Spironolactone results in decreased expression of CAPN1 protein CTD PMID:20082611 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CASP3 caspase 3 decreases expression EXP Spironolactone results in decreased expression of CASP3 protein CTD PMID:20082611 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CAST calpastatin increases expression EXP Spironolactone results in increased expression of CAST protein CTD PMID:20082611 NCBI chr 3:12,920,514...13,031,974
Ensembl chr 3:12,922,453...13,031,959
JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP Spironolactone results in decreased expression of MMP9 protein CTD PMID:20082611 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP Spironolactone results in increased expression of TIMP1 protein CTD PMID:20082611 NCBI chr  X:41,201,623...41,205,314
Ensembl chr  X:41,201,638...41,205,310
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      application 195
        pharmaceutical 192
          drug 192
            diuretic 8
              U50488 0
              U69593 0
              acetazolamide + 0
              amiloride + 0
              amiloride hydrochloride + 0
              amiloride hydrochloride dihydrate 0
              bendroflumethiazide + 0
              benzthiazide 0
              bumetanide 0
              caffeine + 0
              chlormerodrin + 0
              chlorothiazide 0
              cleistanthin A 0
              cleistanthin B + 0
              cyclothiazide 0
              diazoxide 0
              ethoxzolamide 0
              hydrochlorothiazide 0
              hydroflumethiazide 0
              indapamide 0
              loop diuretic + 0
              metolazone 0
              osmotic diuretic + 1
              potassium citrate (anhydrous) + 0
              potassium citrate monohydrate 0
              quinethazone 0
              solasodine 0
              spironolactone 7
              triamterene 0
              trichlormethiazide 0
              trimethoprim + 0
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