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Term:trypanothione disulfide
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Accession:CHEBI:35490 term browser browse the term
Definition:An organic disulfide resulting from the formal oxidative coupling of the thiol groups of N(1),N(8)-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.
Synonyms:exact_synonym: (2S,2'S)-5,5'-{[(4R,23R)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaazacyclotetracosane-4,23-diyl]diimino}bis(2-amino-5-oxopentanoic acid)
 related_synonym: 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID;   Formula=C27H47N9O10S2;   InChI=1S/C27H47N9O10S2/c28-16(26(43)44)4-6-20(37)35-18-14-47-48-15-19(36-21(38)7-5-17(29)27(45)46)25(42)34-13-23(40)32-11-3-9-30-8-1-2-10-31-22(39)12-33-24(18)41/h16-19,30H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46)/t16-,17-,18-,19-/m0/s1;   InChIKey=LZMSXDHGHZKXJD-VJANTYMQSA-N;   Oxidized trypanothione;   SMILES=N[C@@H](CCC(=O)N[C@H]1CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(=O)NCCCNCCCCNC(=O)CNC1=O)C(O)=O;   TSST;   Trypanothiondisulfid
 alt_id: CHEBI:15273;   CHEBI:46005;   CHEBI:8800
 xref: Beilstein:3645155;   CAS:96304-42-6;   KEGG:C03170
 xref_mesh: MESH:C044809
 xref: PDBeChem:TS2
 cyclic_relationship: is_conjugate_base_of CHEBI:58661

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trypanothione disulfide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg1 arginase, liver JBrowse link 10 24,915,207 24,927,470 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21260
    role 21244
      chemical role 20598
        antioxidant 14390
          glutathione 362
            glutathione derivative 57
              trypanothione 1
                trypanothione disulfide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21125
                    p-block element atom 21125
                      carbon group element atom 20894
                        carbon atom 20785
                          organic molecular entity 20785
                            organic group 19179
                              organic divalent group 19169
                                organodiyl group 19169
                                  carbonyl group 19143
                                    carbonyl compound 19143
                                      carboxylic acid 18827
                                        carboacyl group 17518
                                          univalent carboacyl group 17518
                                            carbamoyl group 17226
                                              carboxamide 17226
                                                peptide 9462
                                                  oligopeptide 1184
                                                    tripeptide 871
                                                      glutathione 362
                                                        glutathione derivative 57
                                                          trypanothione 1
                                                            trypanothione disulfide 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.