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Term:trypanothione disulfide
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Accession:CHEBI:35490 term browser browse the term
Definition:An organic disulfide resulting from the formal oxidative coupling of the thiol groups of N(1),N(8)-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.
Synonyms:exact_synonym: (2S,2'S)-5,5'-{[(4R,23R)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaazacyclotetracosane-4,23-diyl]diimino}bis(2-amino-5-oxopentanoic acid)
 related_synonym: 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID;   Formula=C27H47N9O10S2;   InChI=1S/C27H47N9O10S2/c28-16(26(43)44)4-6-20(37)35-18-14-47-48-15-19(36-21(38)7-5-17(29)27(45)46)25(42)34-13-23(40)32-11-3-9-30-8-1-2-10-31-22(39)12-33-24(18)41/h16-19,30H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46)/t16-,17-,18-,19-/m0/s1;   InChIKey=LZMSXDHGHZKXJD-VJANTYMQSA-N;   Oxidized trypanothione;   SMILES=N[C@@H](CCC(=O)N[C@H]1CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(=O)NCCCNCCCCNC(=O)CNC1=O)C(O)=O;   TSST;   Trypanothiondisulfid
 alt_id: CHEBI:15273;   CHEBI:46005;   CHEBI:8800
 xref: Beilstein:3645155;   CAS:96304-42-6;   KEGG:C03170
 xref_mesh: MESH:C044809
 xref: PDBeChem:TS2
 cyclic_relationship: is_conjugate_base_of CHEBI:58661

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trypanothione disulfide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARG1 arginase 1 JBrowse link 6 131,573,226 131,584,329 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23948
    role 23836
      chemical role 22418
        antioxidant 14843
          glutathione 368
            glutathione derivative 58
              trypanothione 1
                trypanothione disulfide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 23948
    subatomic particle 23899
      composite particle 23899
        hadron 23899
          baryon 23899
            nucleon 23899
              atomic nucleus 23899
                atom 23899
                  main group element atom 23720
                    p-block element atom 23720
                      carbon group element atom 23436
                        carbon atom 23392
                          organic molecular entity 23392
                            organic group 22058
                              organic divalent group 22032
                                organodiyl group 22032
                                  carbonyl group 22007
                                    carbonyl compound 22007
                                      carboxylic acid 21059
                                        carboacyl group 19095
                                          univalent carboacyl group 19095
                                            carbamoyl group 18453
                                              carboxamide 18453
                                                peptide 9817
                                                  oligopeptide 1182
                                                    tripeptide 875
                                                      glutathione 368
                                                        glutathione derivative 58
                                                          trypanothione 1
                                                            trypanothione disulfide 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.