CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | organic disulfide |
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Accession: | CHEBI:35489
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browse the term
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Definition: | Compounds of structure RSSR in which R and R' are organic groups. |
Synonyms: | exact_synonym: | disulfides |
| related_synonym: | Formula=S2R2; SMILES=[*]SS[*]; an organic disulfide; organic disulfides |
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Tp53 |
tumor protein p53 |
affects response to substance |
ISO |
TP53 protein affects the susceptibility to 2-hydroxyethyl disulfide |
CTD |
PMID:22926048 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Xrcc5 |
X-ray repair cross complementing 5 |
multiple interactions |
ISO |
[2-hydroxyethyl disulfide co-treated with Glucose deficiency] results in decreased activity of [XRCC5 protein binds to XRCC6 protein] |
CTD |
PMID:22926048 |
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NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
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Xrcc6 |
X-ray repair cross complementing 6 |
multiple interactions |
ISO |
[2-hydroxyethyl disulfide co-treated with Glucose deficiency] results in decreased activity of [XRCC5 protein binds to XRCC6 protein] |
CTD |
PMID:22926048 |
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NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
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Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
ISO |
4,4'-dipyridyl disulfide inhibits the reaction [5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate) binds to KEAP1 protein]; 4,4'-dipyridyl disulfide promotes the reaction [4-(2-pyridylazo)resorcinol inhibits the reaction [Zinc binds to KEAP1 protein]] |
CTD |
PMID:15865434 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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Mgmt |
O-6-methylguanine-DNA methyltransferase |
affects binding |
ISO |
4,4'-dipyridyl disulfide binds to MGMT protein |
CTD |
PMID:12974631 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Casp3 |
caspase 3 |
increases activity |
EXP |
2,2'-dipyridyl disulfide results in increased activity of CASP3 protein |
CTD |
PMID:11331359 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9 |
caspase 9 |
increases activity |
EXP |
2,2'-dipyridyl disulfide results in increased activity of CASP9 protein |
CTD |
PMID:11331359 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phenyl-N-tert-butylnitrone inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
CTD |
PMID:11331359 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK3 protein |
CTD |
PMID:11331359 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nppa |
natriuretic peptide A |
multiple interactions increases expression |
EXP |
polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased expression of NPPA protein] |
CTD |
PMID:25449040 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Ppp1r12a |
protein phosphatase 1, regulatory subunit 12A |
multiple interactions increases phosphorylation |
EXP |
polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein] |
CTD |
PMID:25449040 |
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NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
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Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions decreases activity |
ISO |
allyl methyl disulfide inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] allyl methyl disulfide results in decreased activity of CYP3A4 protein |
CTD |
PMID:18385293 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
allyl methyl disulfide inhibits the reaction [Acetaminophen results in increased activity of GPT protein] |
CTD |
PMID:26969520 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Il6 |
interleukin 6 |
multiple interactions |
ISO |
allyl methyl disulfide inhibits the reaction [Acetaminophen results in increased expression of IL6 protein] |
CTD |
PMID:26969520 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Ptprc |
protein tyrosine phosphatase, receptor type, C |
multiple interactions |
ISO |
allyl methyl disulfide inhibits the reaction [Acetaminophen results in increased expression of PTPRC protein] |
CTD |
PMID:26969520 |
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NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
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Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
allyl methyl disulfide inhibits the reaction [Acetaminophen results in increased expression of TNF protein] |
CTD |
PMID:26969520 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Edn1 |
endothelin 1 |
multiple interactions |
ISO |
chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA]; chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] |
CTD |
PMID:21926265 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Hif1a |
hypoxia inducible factor 1 subunit alpha |
decreases expression multiple interactions |
ISO |
chetomin results in decreased expression of HIF1A mRNA chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]]; chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]] |
CTD |
PMID:19744167 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]] |
CTD |
PMID:19744167 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
chetomin inhibits the reaction [aristolochic acid I results in increased expression of VEGFA protein]; chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]] |
CTD |
PMID:19744167 PMID:21554934 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] |
CTD |
PMID:17708605 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] |
CTD |
PMID:17708605 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Tgm2 |
transglutaminase 2 |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]; Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGM2 protein] |
CTD |
PMID:17708605 |
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NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions |
EXP |
Cystamine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA] |
CTD |
PMID:17708605 |
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NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
diallyl disulfide results in increased expression of ABCB1 mRNA |
CTD |
PMID:22397993 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases expression increases expression |
ISO |
diallyl disulfide results in decreased expression of ABCC1 mRNA diallyl disulfide results in increased expression of ABCC1 mRNA |
CTD |
PMID:22397993 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression affects expression |
ISO |
diallyl disulfide results in increased expression of ABCC3 mRNA diallyl disulfide affects the expression of ABCC3 mRNA |
CTD |
PMID:22397993 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression decreases expression |
ISO |
diallyl disulfide results in increased expression of ABCC4 mRNA diallyl disulfide results in decreased expression of ABCC4 mRNA |
CTD |
PMID:22397993 |
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NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abcc6 |
ATP binding cassette subfamily C member 6 |
decreases expression increases expression |
ISO |
diallyl disulfide results in decreased expression of ABCC6 mRNA diallyl disulfide results in increased expression of ABCC6 mRNA |
CTD |
PMID:22397993 |
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NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Adh1 |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of ADH1 protein] |
CTD |
PMID:35526736 |
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NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Akt1 |
AKT serine/threonine kinase 1 |
increases phosphorylation |
ISO |
diallyl disulfide results in increased phosphorylation of AKT1 protein |
CTD |
PMID:23663050 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aldh2 |
aldehyde dehydrogenase 2 family member |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of ALDH2 protein] |
CTD |
PMID:35526736 |
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NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
diallyl disulfide results in increased expression of ATF3 protein |
CTD |
PMID:15897233 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
diallyl disulfide results in increased expression of BAX mRNA; diallyl disulfide results in increased expression of BAX protein |
CTD |
PMID:17647244 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
EXP ISO |
diallyl disulfide results in decreased expression of BCL2 protein diallyl disulfide results in decreased expression of BCL2 mRNA; diallyl disulfide results in decreased expression of BCL2 protein |
CTD |
PMID:14522920 PMID:16052692 PMID:17647244 PMID:30677442 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf |
brain-derived neurotrophic factor |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of BDNF protein |
CTD |
PMID:23732363 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Birc3 |
baculoviral IAP repeat-containing 3 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of BIRC3 protein |
CTD |
PMID:17647244 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of BIRC5 protein |
CTD |
PMID:17647244 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CASP1 protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CASP1 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased cleavage of CASP1 protein] |
CTD |
PMID:34896185 PMID:35526736 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3 |
caspase 3 |
increases activity increases cleavage multiple interactions |
ISO |
diallyl disulfide results in increased activity of CASP3 protein diallyl disulfide results in increased cleavage of CASP3 protein diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein] |
CTD |
PMID:14522920 PMID:17647244 PMID:30677442 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4 |
caspase 4 |
increases activity |
ISO |
diallyl disulfide results in increased activity of CASP4 protein |
CTD |
PMID:17647244 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp8 |
caspase 8 |
multiple interactions increases cleavage |
ISO |
diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] diallyl disulfide results in increased cleavage of CASP8 protein |
CTD |
PMID:30677442 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9 |
caspase 9 |
increases activity increases cleavage multiple interactions |
ISO |
diallyl disulfide results in increased activity of CASP9 protein diallyl disulfide results in increased cleavage of CASP9 protein diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein] |
CTD |
PMID:14522920 PMID:17647244 PMID:30677442 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cast |
calpastatin |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CAST mRNA; diallyl disulfide results in decreased expression of CAST protein |
CTD |
PMID:17647244 |
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NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
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Cat |
catalase |
multiple interactions |
EXP |
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] |
CTD |
PMID:24293383 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cav1 |
caveolin 1 |
multiple interactions |
ISO |
diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein] |
CTD |
PMID:20229525 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 mRNA] |
CTD |
PMID:34896185 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccnb1 |
cyclin B1 |
decreases expression increases expression |
ISO |
diallyl disulfide results in decreased expression of CCNB1 protein diallyl disulfide results in increased expression of CCNB1 protein |
CTD |
PMID:16691315 PMID:19202565 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnc |
cyclin C |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CCNC mRNA |
CTD |
PMID:31077537 |
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NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
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Cdh1 |
cadherin 1 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CDH1 mRNA; diallyl disulfide results in decreased expression of CDH1 protein |
CTD |
PMID:20600798 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdhr1 |
cadherin-related family member 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDHR1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396
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Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CDK1 protein |
CTD |
PMID:16691315 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdkal1 |
CDK5 regulatory subunit associated protein 1-like 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKAL1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr17:34,718,680...34,769,614 NCBI chr17:34,852,238...35,271,276
Ensembl chr17:34,718,687...35,407,524
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G |
Cdkn2b |
cyclin-dependent kinase inhibitor 2B |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of CDKN2B mRNA |
CTD |
PMID:31077537 |
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NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
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G |
Cldn2 |
claudin 2 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CLDN2 mRNA; diallyl disulfide results in decreased expression of CLDN2 protein |
CTD |
PMID:20600798 |
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NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
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G |
Cldn3 |
claudin 3 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CLDN3 mRNA; diallyl disulfide results in decreased expression of CLDN3 protein |
CTD |
PMID:20600798 |
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NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
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G |
Cldn4 |
claudin 4 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CLDN4 mRNA; diallyl disulfide results in decreased expression of CLDN4 protein |
CTD |
PMID:20600798 |
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NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
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G |
Cldn5 |
claudin 5 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CLDN5 mRNA; diallyl disulfide results in decreased expression of CLDN5 protein |
CTD |
PMID:20600798 |
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NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Cpt1a |
carnitine palmitoyltransferase 1A |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of CPT1A protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of CPT1A protein] |
CTD |
PMID:35526736 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Creb1 |
cAMP responsive element binding protein 1 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of CREB1 protein modified form |
CTD |
PMID:23732363 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Ctnnb1 |
catenin beta 1 |
increases expression decreases phosphorylation |
ISO |
diallyl disulfide results in increased expression of CTNNB1 mRNA; diallyl disulfide results in increased expression of CTNNB1 protein diallyl disulfide results in decreased phosphorylation of CTNNB1 protein |
CTD |
PMID:20600798 PMID:23663050 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression decreases activity |
EXP ISO |
diallyl disulfide results in increased expression of CYP1A1 protein diallyl disulfide results in decreased activity of CYP1A1 protein |
CTD |
PMID:16000231 PMID:18339364 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
EXP |
diallyl disulfide results in increased expression of CYP1A2 protein |
CTD |
PMID:16000231 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
diallyl disulfide results in increased expression of CYP2B1 mRNA; diallyl disulfide results in increased expression of CYP2B2 mRNA |
CTD |
PMID:17353348 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases expression multiple interactions decreases activity |
ISO EXP |
diallyl disulfide results in decreased expression of CYP2E1 protein diallyl disulfide inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein] diallyl disulfide results in decreased activity of CYP2E1 protein [diallyl disulfide results in decreased expression of CYP2E1 protein] which results in decreased metabolism of and results in decreased susceptibility to Trichloroethylene; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein] |
CTD |
PMID:10774820 PMID:16000231 PMID:18339364 PMID:19325051 PMID:24293383 PMID:35526736 More...
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
EXP |
diallyl disulfide results in increased expression of CYP3A2 protein |
CTD |
PMID:16000231 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Dbr1 |
debranching RNA lariats 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of DBR1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
decreases localization |
ISO |
diallyl disulfide results in decreased localization of DIABLO protein |
CTD |
PMID:17647244 |
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NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
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G |
Dus2 |
dihydrouridine synthase 2 |
decreases expression multiple interactions |
EXP |
diallyl disulfide results in decreased expression of DUS2 mRNA [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of DUS2 mRNA |
CTD |
PMID:31077537 |
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NCBI chr19:33,906,517...33,954,922
Ensembl chr19:33,911,750...33,954,709
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G |
Exo1 |
exonuclease 1 |
increases expression multiple interactions |
EXP |
diallyl disulfide results in increased expression of EXO1 mRNA [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of EXO1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of FASN protein] |
CTD |
PMID:35526736 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of FOSL1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
EXP ISO |
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] diallyl disulfide results in increased expression of GCLC mRNA; diallyl disulfide results in increased expression of GCLC protein [diallyl disulfide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of GCLC protein; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC mRNA]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC protein]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC mRNA]] |
CTD |
PMID:24293383 PMID:34896185 PMID:35526736 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
ISO |
diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GCLM mRNA]] diallyl disulfide results in increased expression of GCLM mRNA |
CTD |
PMID:34896185 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression multiple interactions |
ISO |
diallyl disulfide results in increased expression of GDF15 protein TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein] |
CTD |
PMID:11925476 |
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NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP ISO |
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of GPT protein] |
CTD |
PMID:24293383 PMID:34896185 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Grb2 |
growth factor receptor bound protein 2 |
affects expression decreases expression |
ISO |
diallyl disulfide affects the expression of GRB2 protein diallyl disulfide results in decreased expression of GRB2 protein |
CTD |
PMID:21695758 |
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NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Grhl1 |
grainyhead-like transcription factor 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of GRHL1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 6:41,207,325...41,257,516
Ensembl chr 6:41,207,348...41,254,301
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
ISO |
diallyl disulfide results in increased phosphorylation of GSK3B protein |
CTD |
PMID:23663050 |
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] |
CTD |
PMID:24293383 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of HES1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP ISO |
[Carbon Tetrachloride co-treated with diallyl disulfide] results in increased expression of HMOX1 protein; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA] diallyl disulfide results in increased expression of HMOX1 mRNA; diallyl disulfide results in increased expression of HMOX1 protein [diallyl disulfide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of HMOX1 protein; diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]] |
CTD |
PMID:24293383 PMID:34896185 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
increases expression multiple interactions |
EXP |
diallyl disulfide results in increased expression of HSPA1A mRNA [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPA1A mRNA |
CTD |
PMID:31077537 |
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NCBI chr20:3,870,765...3,873,221
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G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
multiple interactions decreases expression |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPH1 mRNA diallyl disulfide results in decreased expression of HSPH1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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G |
Id1 |
inhibitor of DNA binding 1 |
multiple interactions increases expression |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID1 mRNA diallyl disulfide results in increased expression of ID1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression multiple interactions |
EXP |
diallyl disulfide results in increased expression of ID2 mRNA [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID2 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Id3 |
inhibitor of DNA binding 3 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of ID3 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of IL1B protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] |
CTD |
PMID:34896185 PMID:35526736 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] |
CTD |
PMID:34896185 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Itgb1bp1 |
integrin subunit beta 1 binding protein 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of ITGB1BP1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases phosphorylation |
ISO |
diallyl disulfide results in increased phosphorylation of JUN protein |
CTD |
PMID:14522920 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases expression multiple interactions |
ISO |
diallyl disulfide results in decreased expression of KEAP1 protein diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of KEAP1 protein] |
CTD |
PMID:34896185 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Kit |
KIT proto-oncogene receptor tyrosine kinase |
increases expression |
ISO |
diallyl disulfide results in increased expression of KIT protein |
CTD |
PMID:23663050 |
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NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
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G |
Klf2 |
KLF transcription factor 2 |
increases expression multiple interactions |
EXP |
diallyl disulfide results in increased expression of KLF2 mRNA [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of KLF2 mRNA |
CTD |
PMID:31077537 |
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NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944
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G |
Malsu1 |
mitochondrial assembly of ribosomal large subunit 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MALSU1 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 4:78,051,090...78,059,913
Ensembl chr 4:78,051,059...78,059,905
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G |
Map2k7 |
mitogen activated protein kinase kinase 7 |
affects expression |
ISO |
diallyl disulfide affects the expression of MAP2K7 protein |
CTD |
PMID:21695758 |
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NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
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G |
Map3k3 |
mitogen activated protein kinase kinase kinase 3 |
affects expression |
ISO |
diallyl disulfide affects the expression of MAP3K3 protein |
CTD |
PMID:21695758 |
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NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases expression increases phosphorylation |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK1 protein] diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein] diallyl disulfide results in decreased expression of MAPK1 protein |
CTD |
PMID:17263507 PMID:21695758 PMID:34896185 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions decreases expression |
EXP ISO |
diallyl disulfide results in increased phosphorylation of MAPK3 protein diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein] diallyl disulfide results in decreased expression of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [diallyl disulfide results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:17263507 PMID:21695758 PMID:34896185 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation multiple interactions |
ISO |
diallyl disulfide results in increased phosphorylation of MAPK8 protein diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein] diallyl disulfide results in increased phosphorylation of and results in increased activity of MAPK8 protein |
CTD |
PMID:14522920 PMID:17647244 PMID:34896185 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of MDM2 mRNA |
CTD |
PMID:31077537 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases expression |
ISO |
diallyl disulfide results in decreased expression of and results in decreased activity of MMP2 protein diallyl disulfide results in decreased expression of MMP2 mRNA; diallyl disulfide results in decreased expression of MMP2 protein |
CTD |
PMID:20600798 PMID:21695758 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of MMP7 protein |
CTD |
PMID:21695758 |
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NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions affects expression decreases expression |
ISO |
diallyl disulfide results in decreased expression of and results in decreased activity of MMP9 protein diallyl disulfide affects the expression of MMP9 protein diallyl disulfide results in decreased expression of MMP9 mRNA |
CTD |
PMID:20600798 PMID:21695758 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mogs |
mannosyl-oligosaccharide glucosidase |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of MOGS mRNA |
CTD |
PMID:31077537 |
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NCBI chr 4:115,621,623...115,625,026
Ensembl chr 4:115,621,623...115,625,032
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases expression decreases degradation |
EXP ISO |
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NFE2L2 protein] diallyl disulfide results in decreased expression of NFE2L2 mRNA diallyl disulfide affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFE2L2 protein]; diallyl disulfide inhibits the reaction [Ethanol affects the expression of NFE2L2 protein]; diallyl disulfide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]] diallyl disulfide results in decreased degradation of NFE2L2 protein |
CTD |
PMID:24293383 PMID:34896185 PMID:35526736 |
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NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation multiple interactions increases expression |
ISO EXP |
diallyl disulfide results in increased phosphorylation of NFKBIA protein diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NFKBIA protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NFKBIA protein modified form]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] [Cadmium Chloride co-treated with diallyl disulfide] results in increased expression of NFKBIA mRNA diallyl disulfide results in increased expression of NFKBIA mRNA |
CTD |
PMID:23663050 PMID:31077537 PMID:34896185 PMID:35526736 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NLRP3 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NLRP3 protein] |
CTD |
PMID:34896185 PMID:35526736 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nos2 |
nitric oxide synthase 2 |
affects expression multiple interactions |
ISO |
diallyl disulfide affects the expression of NOS2 protein diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] |
CTD |
PMID:21695758 PMID:34896185 PMID:35526736 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases expression increases phosphorylation decreases degradation |
ISO |
diallyl disulfide promotes the reaction [NOS3 protein binds to CAV1 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein] diallyl disulfide results in increased expression of NOS3 protein diallyl disulfide results in decreased degradation of NOS3 protein |
CTD |
PMID:20229525 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity multiple interactions increases expression |
EXP ISO |
diallyl disulfide results in increased activity of NQO1 protein diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NQO1 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 protein]; diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA]] diallyl disulfide results in increased expression of NQO1 mRNA; diallyl disulfide results in increased expression of NQO1 protein diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA]; diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein] |
CTD |
PMID:8339252 PMID:24293383 PMID:34896185 PMID:35526736 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] |
CTD |
PMID:30677442 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pmp22 |
peripheral myelin protein 22 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PMP22 mRNA |
CTD |
PMID:31077537 |
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NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of PPARA protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of PPARA protein] |
CTD |
PMID:35526736 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppp3ca |
protein phosphatase 3 catalytic subunit alpha |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PPP3CA mRNA |
CTD |
PMID:31077537 |
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NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
affects expression multiple interactions |
ISO |
diallyl disulfide affects the expression of PTGS2 protein diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of PTGS2 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of PTGS2 protein] |
CTD |
PMID:21695758 PMID:35526736 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of PYCARD protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of PYCARD protein] |
CTD |
PMID:35526736 |
|
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of RELA protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of RELA protein modified form]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of RELA protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] |
CTD |
PMID:34896185 PMID:35526736 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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|
G |
Sesn2 |
sestrin 2 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SESN2 mRNA |
CTD |
PMID:31077537 |
|
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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G |
Sfn |
stratifin |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SFN mRNA |
CTD |
PMID:31077537 |
|
Ensembl chr 5:145,826,201...145,831,314
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of SNAI1 mRNA; diallyl disulfide results in decreased expression of SNAI1 protein |
CTD |
PMID:20600798 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD1 mRNA] |
CTD |
PMID:24293383 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [Ethanol results in increased expression of SREBF1 protein] |
CTD |
PMID:35526736 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Stag1 |
stromal antigen 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of STAG1 mRNA |
CTD |
PMID:31077537 |
|
NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677
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G |
Sumo1 |
small ubiquitin-like modifier 1 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of SUMO1 mRNA |
CTD |
PMID:31077537 |
|
NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761
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G |
Tfdp2 |
transcription factor Dp-2 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TFDP2 mRNA |
CTD |
PMID:31077537 |
|
NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
diallyl disulfide results in increased expression of TIMP1 mRNA |
CTD |
PMID:20600798 |
|
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
ISO |
diallyl disulfide results in increased expression of TIMP2 mRNA |
CTD |
PMID:20600798 |
|
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases secretion |
ISO |
diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased secretion of TNF protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]] diallyl disulfide results in decreased secretion of TNF protein |
CTD |
PMID:34896185 PMID:35526736 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP3 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of CASP9 protein]; diallyl disulfide promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein] |
CTD |
PMID:30677442 |
|
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO EXP |
Acetylcysteine inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; TP53 protein affects the reaction [diallyl disulfide results in increased expression of GDF15 protein] [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TP53 mRNA |
CTD |
PMID:11925476 PMID:19202565 PMID:31077537 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tsg101 |
tumor susceptibility 101 |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of TSG101 mRNA |
CTD |
PMID:31077537 |
|
NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554
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G |
Txnrd1 |
thioredoxin reductase 1 |
multiple interactions |
ISO |
diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of TXNRD1 protein] |
CTD |
PMID:35526736 |
|
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Ube2h |
ubiquitin-conjugating enzyme E2H |
multiple interactions |
EXP |
[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of UBE2H mRNA |
CTD |
PMID:31077537 |
|
NCBI chr 4:58,834,674...58,930,156
Ensembl chr 4:58,834,674...58,930,156
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases activity |
EXP |
diallyl disulfide results in increased activity of UGT1A1 protein |
CTD |
PMID:8339252 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
diallyl disulfide results in decreased expression of XIAP protein |
CTD |
PMID:17647244 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IFNG protein |
CTD |
PMID:12062936 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein |
CTD |
PMID:12062936 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
n-propyl disulfide results in decreased activity of CYP1A1 protein |
CTD |
PMID:18339364 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
n-propyl disulfide results in decreased activity of CYP2E1 protein |
CTD |
PMID:18339364 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
EXP |
n-propyl disulfide results in increased expression of CYP3A2 protein |
CTD |
PMID:16000231 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of AARS1 mRNA |
CTD |
PMID:24690739 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abat |
4-aminobutyrate aminotransferase |
multiple interactions |
EXP |
[Ethanol co-treated with Disulfiram] results in decreased activity of ABAT protein; [Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNA |
CTD |
PMID:9591243 |
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NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
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G |
Abca1 |
ATP binding cassette subfamily A member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ABCA1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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G |
Abca3 |
ATP binding cassette subfamily A member 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ABCA3 mRNA |
CTD |
PMID:24690739 |
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NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity multiple interactions |
ISO |
Disulfiram results in decreased activity of ABCB11 protein Disulfiram inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity multiple interactions |
ISO |
Disulfiram metabolite results in decreased activity of ABCB1 protein; Disulfiram results in decreased activity of ABCB1 protein Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidopine binds to ABCB1 protein]; Disulfiram inhibits the reaction [azidoprazosin binds to ABCB1 protein] |
CTD |
PMID:10841824 PMID:14978246 PMID:16028354 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity multiple interactions |
ISO |
Disulfiram results in decreased activity of ABCC1 protein Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC1 protein] |
CTD |
PMID:14978246 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC4 protein]; Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
CTD |
PMID:14978246 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcg1 |
ATP binding cassette subfamily G member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ABCG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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G |
Acad11 |
acyl-CoA dehydrogenase family, member 11 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ACAD11 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560
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G |
Ace2 |
angiotensin I converting enzyme 2 |
decreases expression |
ISO |
Disulfiram results in decreased expression of ACE2 mRNA |
CTD |
PMID:32808185 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ache |
acetylcholinesterase |
decreases expression |
EXP |
Disulfiram results in decreased expression of ACHE protein |
CTD |
PMID:3868355 |
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NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Acss2 |
acyl-CoA synthetase short-chain family member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ACSS2 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ACTA2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adam9 |
ADAM metallopeptidase domain 9 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ADAM9 mRNA |
CTD |
PMID:24690739 |
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NCBI chr16:67,022,538...67,101,647
Ensembl chr16:67,022,655...67,100,917
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G |
Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ADAMTS1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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G |
Adarb1 |
adenosine deaminase, RNA-specific, B1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ADARB1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852
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G |
Adcy3 |
adenylate cyclase 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ADCY3 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
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G |
Adgre5 |
adhesion G protein-coupled receptor E5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ADGRE5 mRNA |
CTD |
PMID:24690739 |
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NCBI chr19:24,397,972...24,418,648
Ensembl chr19:24,398,689...24,418,638
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G |
Adh1 |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
decreases activity |
EXP |
Disulfiram results in decreased activity of ADH1 protein |
CTD |
PMID:15551062 |
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NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Adm |
adrenomedullin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ADM mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G |
Afap1 |
actin filament associated protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of AFAP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:74,743,322...74,856,295
Ensembl chr14:74,743,320...74,856,263
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G |
Agxt |
alanine--glyoxylate aminotransferase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of AGXT mRNA |
CTD |
PMID:24690739 |
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NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
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G |
Agxt2 |
alanine-glyoxylate aminotransferase 2 |
multiple interactions |
EXP |
[Ethanol co-treated with Disulfiram] results in decreased activity of AGXT2 protein |
CTD |
PMID:9591243 |
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NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
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G |
Ahsa1 |
activator of Hsp90 ATPase activity 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of AHSA1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:106,913,296...106,921,347
Ensembl chr 6:106,913,530...106,921,345
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
increases expression |
ISO |
Disulfiram results in increased expression of AKR1B1 mRNA |
CTD |
PMID:20566472 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression |
ISO |
Disulfiram results in increased expression of AKR1B10 mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
increases expression |
ISO |
Disulfiram results in increased expression of AKR1C1 mRNA |
CTD |
PMID:20566472 |
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NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
increases expression |
ISO |
Disulfiram results in increased expression of AKR1C3 mRNA |
CTD |
PMID:20566472 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Alad |
aminolevulinate dehydratase |
multiple interactions |
EXP |
[Disulfiram co-treated with Lead] results in decreased activity of ALAD protein |
CTD |
PMID:2748540 |
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NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
decreases activity decreases expression multiple interactions |
EXP ISO |
Disulfiram results in decreased activity of ALDH1A1 protein Disulfiram results in decreased expression of ALDH1A1 mRNA; Disulfiram results in decreased expression of ALDH1A1 protein Disulfiram inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to maphosphamide] |
CTD |
PMID:8562935 PMID:10998257 PMID:21035945 PMID:34242567 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
decreases activity |
ISO |
Disulfiram results in decreased activity of ALDH1A2 protein |
CTD |
PMID:22079344 |
|
NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
decreases activity decreases expression multiple interactions |
ISO EXP |
Disulfiram metabolite results in decreased activity of ALDH2 protein; Disulfiram results in decreased activity of ALDH2 protein Disulfiram results in decreased expression of ALDH2 mRNA [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde |
CTD |
PMID:9585485 PMID:10513990 PMID:11142365 PMID:21334317 PMID:21376711 PMID:22079344 PMID:24496638 More...
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NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
increases metabolic processing |
ISO |
ALDH3A1 protein results in increased metabolism of Disulfiram |
CTD |
PMID:18591790 |
|
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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G |
Angptl4 |
angiopoietin-like 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ANGPTL4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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G |
Ano6 |
anoctamin 6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ANO6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:126,933,629...127,113,589
Ensembl chr 7:126,933,936...127,113,589
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G |
Apbb3 |
amyloid beta precursor protein binding family B member 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of APBB3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:28,273,168...28,280,347
Ensembl chr18:28,270,545...28,280,094
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G |
Apcdd1l |
APC down-regulated 1 like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of APCDD1L mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:162,587,484...162,658,362
Ensembl chr 3:162,582,252...162,658,073
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of APP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
[Disulfiram co-treated with cupric chloride] results in decreased expression of AR protein; Disulfiram inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] |
CTD |
PMID:19789329 PMID:33049310 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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|
G |
Arc |
activity-regulated cytoskeleton-associated protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ARC mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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|
G |
Asgr1 |
asialoglycoprotein receptor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ASGR1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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G |
Asmtl |
acetylserotonin O-methyltransferase-like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ASMTL mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:16,315,335...16,321,607
Ensembl chr12:16,315,414...16,318,080
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|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ASNS mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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|
G |
Atf1 |
activating transcription factor 1 |
multiple interactions |
ISO |
[Disulfiram co-treated with Copper] results in decreased activity of ATF1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF1 protein] |
CTD |
PMID:15367699 |
|
NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
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|
G |
Atf2 |
activating transcription factor 2 |
multiple interactions |
ISO |
[Disulfiram co-treated with Copper] results in decreased activity of ATF2 protein; Copper promotes the reaction [Disulfiram results in decreased activity of ATF2 protein] |
CTD |
PMID:15367699 |
|
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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|
G |
Atf3 |
activating transcription factor 3 |
multiple interactions increases expression |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ATF3 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA] |
CTD |
PMID:24690739 PMID:32661532 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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|
G |
Atg101 |
autophagy related 101 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ATG101 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:132,398,477...132,407,643
Ensembl chr 7:132,398,483...132,407,633
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|
G |
Atp2b1 |
ATPase plasma membrane Ca2+ transporting 1 |
decreases expression |
EXP |
Disulfiram results in decreased expression of ATP2B1 mRNA |
CTD |
PMID:15003327 |
|
NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
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|
G |
Atp5mk |
ATP synthase membrane subunit K |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ATP5MK mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:245,973,910...245,980,702
Ensembl chr 1:245,973,914...245,980,761
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|
G |
Atp6v0d1 |
ATPase H+ transporting V0 subunit D1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ATP6V0D1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
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|
G |
Atp6v1g1 |
ATPase H+ transporting V1 subunit G1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ATP6V1G1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:76,961,462...76,967,642
Ensembl chr 5:76,961,499...76,969,463
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|
G |
Atxn1l |
ataxin 1-like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ATXN1L mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:37,700,341...37,711,524
Ensembl chr19:37,700,106...37,711,538
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|
G |
Atxn3 |
ataxin 3 |
increases response to substance affects localization |
ISO |
ATXN3 protein alternative form results in increased susceptibility to Disulfiram Disulfiram affects the localization of ATXN3 protein alternative form |
CTD |
PMID:31378764 |
|
NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
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|
G |
Bag3 |
BAG cochaperone 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of BAG3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858
|
|
G |
Bak1 |
BCL2-antagonist/killer 1 |
multiple interactions |
ISO |
[arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BAK1 protein |
CTD |
PMID:24126434 |
|
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Disulfiram results in increased expression of BAX protein [arsenic trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in increased expression of BAX protein; [Copper co-treated with Disulfiram] results in increased expression of BAX protein |
CTD |
PMID:17079463 PMID:23033007 PMID:24126434 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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|
G |
Bbs2 |
Bardet-Biedl syndrome 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of BBS2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993
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|
G |
Bccip |
BRCA2 and CDKN1A interacting protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of BCCIP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:188,512,544...188,524,957
Ensembl chr 1:188,512,367...188,524,958
|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[Arsenic Trioxide co-treated with Ascorbic Acid co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Copper co-treated with Disulfiram] results in decreased expression of BCL2 protein; [Disulfiram co-treated with cupric chloride] results in decreased expression of BCL2 protein |
CTD |
PMID:21911303 PMID:23033007 PMID:24126434 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of BDNF mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Bglap |
bone gamma-carboxyglutamate protein |
increases expression |
EXP |
Disulfiram results in increased expression of BGLAP mRNA |
CTD |
PMID:24496638 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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|
G |
Bmp7 |
bone morphogenetic protein 7 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA] |
CTD |
PMID:22285649 |
|
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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|
G |
Brf2 |
BRF2, RNA polymerase III transcription initiation factor subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of BRF2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059
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|
G |
Btk |
Bruton tyrosine kinase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of BTK mRNA |
CTD |
PMID:24690739 |
|
NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853
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|
G |
C1r |
complement C1r |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of C1R mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
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|
G |
C1s |
complement C1s |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of C1S mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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|
G |
Cacybp |
calcyclin binding protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CACYBP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177
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|
G |
Calcb |
calcitonin-related polypeptide, beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CALCB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:168,966,465...168,970,125
Ensembl chr 1:168,966,465...168,970,125
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|
G |
Cald1 |
caldesmon 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CALD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:63,265,781...63,446,936
Ensembl chr 4:63,265,942...63,446,932
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|
G |
Car2 |
carbonic anhydrase 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CA2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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|
G |
Car7 |
carbonic anhydrase 7 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CA7 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
EXP ISO |
[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein] [Disulfiram binds to Copper] which results in increased activity of CASP3 protein [Disulfiram binds to Copper] which results in increased activity of CASP3 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of CASP3 protein] Disulfiram results in increased activity of CASP3 protein |
CTD |
PMID:11239917 PMID:17026967 PMID:17079463 PMID:24193513 PMID:24690739 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp7 |
caspase 7 |
increases activity |
ISO |
Disulfiram results in increased activity of CASP7 protein |
CTD |
PMID:17026967 |
|
NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased activity of CASP9 protein |
CTD |
PMID:24690739 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Cat |
catalase |
increases expression multiple interactions decreases expression |
ISO |
Disulfiram results in increased expression of CAT mRNA Zinc Sulfate inhibits the reaction [Disulfiram results in decreased expression of CAT mRNA] |
CTD |
PMID:20566472 PMID:32712770 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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|
G |
Ccar1 |
cell division cycle and apoptosis regulator 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CCAR1 protein |
CTD |
PMID:24690739 |
|
NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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|
G |
Ccdc59 |
coiled-coil domain containing 59 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CCDC59 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:41,142,760...41,149,143
Ensembl chr 7:41,142,760...41,149,143
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|
G |
Ccdc92 |
coiled-coil domain containing 92 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CCDC92 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:31,796,102...31,823,333
Ensembl chr12:31,796,684...31,823,337
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|
G |
Cck |
cholecystokinin |
decreases expression multiple interactions |
EXP ISO |
Disulfiram results in decreased expression of CCK protein alternative form [Disulfiram binds to Copper] which results in decreased expression of CCK mRNA |
CTD |
PMID:8246921 PMID:24690739 |
|
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions decreases secretion |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CCL2 mRNA; [Zinc Sulfate co-treated with Disulfiram] inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] Disulfiram results in decreased secretion of CCL2 protein |
CTD |
PMID:24690739 PMID:32712770 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Ccl26 |
C-C motif chemokine ligand 26 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CCL26 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
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|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein] [Disulfiram binds to Copper] which results in increased expression of CCL5 mRNA |
CTD |
PMID:19016906 PMID:24690739 |
|
NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
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|
G |
Ccna2 |
cyclin A2 |
multiple interactions |
ISO |
[Disulfiram co-treated with Copper] results in decreased expression of CCNA2 protein |
CTD |
PMID:15367699 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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|
G |
Ccnd2 |
cyclin D2 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA] |
CTD |
PMID:22285649 |
|
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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|
G |
Ccnk |
cyclin K |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CCNK mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
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|
G |
Ccpg1 |
cell cycle progression 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CCPG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
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|
G |
Ccr2 |
C-C motif chemokine receptor 2 |
increases expression |
ISO |
Disulfiram results in increased expression of CCR2 protein |
CTD |
PMID:32712770 |
|
NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
|
|
G |
Ccr5 |
C-C motif chemokine receptor 5 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Reactive Oxygen Species]; Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein] |
CTD |
PMID:19016906 |
|
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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|
G |
Cd163 |
CD163 molecule |
multiple interactions decreases expression |
ISO |
[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD163 mRNA Disulfiram results in decreased expression of CD163 mRNA |
CTD |
PMID:32712770 |
|
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
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|
G |
Cd36 |
CD36 molecule |
multiple interactions decreases expression |
ISO |
[Zinc Sulfate co-treated with Disulfiram] results in decreased expression of CD36 mRNA Disulfiram results in decreased expression of CD36 mRNA |
CTD |
PMID:32712770 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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|
G |
Cd46 |
CD46 molecule |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CD46 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
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|
G |
Cd47 |
Cd47 molecule |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CD47 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
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|
G |
Cd9 |
CD9 molecule |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CD9 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222
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|
G |
Cdc42ep5 |
CDC42 effector protein 5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CDC42EP5 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:70,035,921...70,038,990
|
|
G |
Cdh11 |
cadherin 11 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CDH11 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272
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|
G |
Cdh2 |
cadherin 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CDH2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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|
G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CDK5R1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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|
G |
Cdk5rap3 |
CDK5 regulatory subunit associated protein 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CDK5RAP3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
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|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression multiple interactions |
ISO |
Disulfiram results in increased expression of CDKN1B protein [Disulfiram binds to Copper] which results in increased expression of CDKN1B protein |
CTD |
PMID:17079463 PMID:24690739 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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|
G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CDKN1C mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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|
G |
Cdkn2aip |
CDKN2A interacting protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CDKN2AIP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033
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|
G |
Cemip |
cell migration inducing hyaluronidase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CEMIP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:137,906,921...138,062,430
Ensembl chr 1:137,908,920...138,062,415
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|
G |
Cenpw |
centromere protein W |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CENPW mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464
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|
G |
Cfap53 |
cilia and flagella associated protein 53 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CFAP53 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:67,884,651...67,955,873
Ensembl chr18:67,869,855...67,952,318
|
|
G |
Cfb |
complement factor B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CFB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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G |
Chga |
chromogranin A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CHGA mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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G |
Chmp1b |
charged multivesicular body protein 1B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CHMP1B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:60,740,349...60,742,879
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G |
Chordc1 |
cysteine and histidine rich domain containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CHORDC1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162
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G |
Cilp |
cartilage intermediate layer protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CILP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:65,777,281...65,792,251
Ensembl chr 8:65,777,281...65,792,251
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G |
Cirbp |
cold inducible RNA binding protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CIRBP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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G |
Ckap4 |
cytoskeleton-associated protein 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CKAP4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:19,230,814...19,238,914
Ensembl chr 7:19,230,203...19,238,914
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G |
Cldn1 |
claudin 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CLDN1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Clec7a |
C-type lectin domain containing 7A |
increases expression |
ISO |
Disulfiram results in increased expression of CLEC7A protein |
CTD |
PMID:32712770 |
|
NCBI chr 4:162,902,731...162,913,931
Ensembl chr 4:162,902,732...162,913,897
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G |
Clp1 |
cleavage factor polyribonucleotide kinase subunit 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CLP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:69,806,774...69,818,633
Ensembl chr 3:69,806,778...69,810,421
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G |
Clta |
clathrin, light chain A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CLTA mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:58,244,253...58,263,480
Ensembl chr 5:58,245,442...58,263,472
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|
G |
Cmklr2 |
chemerin chemokine-like receptor 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CMKLR2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:64,583,310...64,618,127
Ensembl chr 9:64,585,594...64,586,655
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|
G |
Cntnap1 |
contactin associated protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CNTNAP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611
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G |
Col12a1 |
collagen type XII alpha 1 chain |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of COL12A1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686
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G |
Col1a2 |
collagen type I alpha 2 chain |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of COL1A2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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|
G |
Col3a1 |
collagen type III alpha 1 chain |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of COL3A1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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|
G |
Col4a1 |
collagen type IV alpha 1 chain |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of COL4A1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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|
G |
Col5a1 |
collagen type V alpha 1 chain |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of COL5A1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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|
G |
Commd9 |
COMM domain containing 9 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of COMMD9 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:88,175,909...88,190,427
Ensembl chr 3:88,175,987...88,190,439
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G |
Crabp2 |
cellular retinoic acid binding protein 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CRABP2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
[Disulfiram co-treated with Copper] results in decreased activity of CREB1 protein; Copper promotes the reaction [Disulfiram results in decreased activity of CREB1 protein] |
CTD |
PMID:15367699 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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|
G |
Creld2 |
cysteine-rich with EGF-like domains 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CRELD2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
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|
G |
Crim1 |
cysteine rich transmembrane BMP regulator 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CRIM1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259
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G |
Cript |
CXXC repeat containing interactor of PDZ3 domain |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CRIPT mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:7,581,428...7,589,384
Ensembl chr 6:7,580,703...7,589,399
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|
G |
Crispld2 |
cysteine-rich secretory protein LCCL domain containing 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CRISPLD2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
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G |
Cryab |
crystallin, alpha B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CRYAB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
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G |
Cse1l |
chromosome segregation 1 like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CSE1L mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865
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G |
Csnk1e |
casein kinase 1, epsilon |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CSNK1E mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794
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G |
Csrnp1 |
cysteine and serine rich nuclear protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of AXUD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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G |
Csrp2 |
cysteine and glycine-rich protein 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CSRP2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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G |
Cst6 |
cystatin E/M |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030
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G |
Cth |
cystathionine gamma-lyase |
increases expression |
ISO |
Disulfiram results in increased expression of CTH protein |
CTD |
PMID:34242567 |
|
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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|
G |
Cwc25 |
CWC25 spliceosome-associated protein homolog |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CWC25 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:82,735,698...82,760,373
Ensembl chr10:82,736,995...82,760,354
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G |
Cxcr4 |
C-X-C motif chemokine receptor 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of CXCR4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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|
G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA] |
CTD |
PMID:22285649 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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|
G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA] |
CTD |
PMID:22285649 |
|
NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Disulfiram results in decreased activity of CYP1A1 protein |
CTD |
PMID:33814510 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Disulfiram results in decreased activity of CYP1B1 protein |
CTD |
PMID:33814510 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions increases expression |
EXP |
GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA] |
CTD |
PMID:8390837 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
increases expression multiple interactions |
EXP |
Disulfiram results in increased expression of CYP2B2 mRNA GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA] |
CTD |
PMID:8390837 |
|
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases activity decreases expression |
EXP |
Disulfiram results in decreased activity of CYP2C11 protein Disulfiram results in decreased expression of CYP2C11 protein |
CTD |
PMID:9393675 |
|
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions decreases activity decreases expression |
ISO EXP |
[Disulfiram results in decreased activity of CYP2E1 protein] which affects the activity of Styrene; Disulfiram inhibits the reaction [[CYP2E1 protein results in increased metabolism of Chlorzoxazone] which results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]; Disulfiram inhibits the reaction [CYP2E1 protein results in increased oxidation of Halothane] Disulfiram results in decreased expression of CYP2E1 mRNA; Disulfiram results in decreased expression of CYP2E1 protein Disulfiram binds to and results in decreased activity of CYP2E1 protein |
CTD |
PMID:1664256 PMID:8637342 PMID:9393675 PMID:10805064 PMID:18754103 PMID:20470765 PMID:21915887 PMID:23669205 More...
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2r1 |
cytochrome P450, family 2, subfamily r, polypeptide 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CYP2R1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:168,749,302...168,798,079
Ensembl chr 1:168,751,038...168,797,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases expression increases response to substance decreases activity |
EXP ISO |
Disulfiram results in decreased expression of CYP3A2 mRNA CYP3A4 protein results in increased susceptibility to Disulfiram Disulfiram results in decreased activity of CYP3A2 protein |
CTD |
PMID:9393675 PMID:21540358 |
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NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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G |
Dag1 |
dystroglycan 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of DAG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325
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G |
Dbh |
dopamine beta-hydroxylase |
decreases activity affects response to substance |
ISO |
Disulfiram results in decreased activity of DBH protein DBH gene SNP affects the susceptibility to Disulfiram DBH gene polymorphism affects the susceptibility to Disulfiram |
CTD |
PMID:90468 PMID:16163519 PMID:19462300 |
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NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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G |
Dcaf13 |
DDB1 and CUL4 associated factor 13 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DCAF13 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:70,160,983...70,196,142
Ensembl chr 7:70,160,941...70,196,142
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G |
Dcxr |
dicarbonyl and L-xylulose reductase |
multiple interactions |
ISO |
[Disulfiram co-treated with NADP] binds to DCXR protein |
CTD |
PMID:25526675 |
|
NCBI chr10:106,006,404...106,008,294
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DDIT3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddx39a |
DExD-box helicase 39A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DDX39A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:24,418,743...24,427,422
Ensembl chr19:24,418,114...24,426,954
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G |
Ddx60 |
DEXD/H-box helicase 60 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of DDX60 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:28,077,000...28,197,903
Ensembl chr16:28,076,999...28,179,526
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G |
Dedd2 |
death effector domain containing 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DEDD2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714
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G |
Dhdh |
dihydrodiol dehydrogenase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DHDH mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197
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G |
Dhrs2 |
dehydrogenase/reductase 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DHRS2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of DHRS3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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G |
Dkk3 |
dickkopf WNT signaling pathway inhibitor 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of DKK3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590
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G |
Dll1 |
delta like canonical Notch ligand 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DLL1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
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G |
Dnaja1 |
DnaJ heat shock protein family (Hsp40) member A1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DNAJA1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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G |
Dnaja4 |
DnaJ heat shock protein family (Hsp40) member A4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DNAJA4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207
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G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DNAJB1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:24,522,717...24,526,458
Ensembl chr19:24,522,717...24,526,458
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G |
Dnajb6 |
DnaJ heat shock protein family (Hsp40) member B6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DNAJB6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659
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G |
Dnajc3 |
DnaJ heat shock protein family (Hsp40) member C3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DNAJC3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
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G |
Dph3 |
diphthamide biosynthesis 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DPH3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:7,288,295...7,293,734
Ensembl chr16:7,282,705...7,291,265
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G |
Dram1 |
DNA-damage regulated autophagy modulator 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of DRAM1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765
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G |
Dse |
dermatan sulfate epimerase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of DSE mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
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G |
Dusp2 |
dual specificity phosphatase 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DUSP2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499
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G |
Dusp5 |
dual specificity phosphatase 5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DUSP5 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dynll2 |
dynein light chain LC8-type 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of DYNLL2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805
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G |
Eaf1 |
ELL associated factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of EAF1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:6,698,322...6,713,071
Ensembl chr16:6,698,322...6,713,071
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|
G |
Edil3 |
EGF like repeats and discoidin domains 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of EDIL3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008
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|
G |
Eed |
embryonic ectoderm development |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of EED mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974
|
|
G |
Efemp1 |
EGF containing fibulin extracellular matrix protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of EFEMP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
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|
G |
Egr1 |
early growth response 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of EGR1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
|
|
G |
Eif4a3 |
eukaryotic translation initiation factor 4A3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of EIF4A3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
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|
G |
Ell2 |
elongation factor for RNA polymerase II 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ELL2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
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|
G |
Elof1 |
elongation factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ELOF1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:20,645,336...20,650,888
Ensembl chr 8:20,645,336...20,650,579
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|
G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO |
Disulfiram binds to and results in decreased activity of ESR1 protein |
CTD |
PMID:33049310 |
|
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
|
|
G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ETS1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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|
G |
F12 |
coagulation factor XII |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of F12 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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|
G |
Fam210a |
family with sequence similarity 210, member A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FAM210A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
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|
G |
Fam234a |
family with sequence similarity 234, member A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of FAM234A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:15,232,267...15,263,529
Ensembl chr10:15,232,278...15,263,488
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|
G |
Fam32a |
family with sequence similarity 32, member A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FAM32A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398
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|
G |
Fech |
ferrochelatase |
increases expression |
ISO |
Disulfiram results in increased expression of FECH mRNA |
CTD |
PMID:20566472 |
|
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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|
G |
Fkbp1a |
FKBP prolyl isomerase 1A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FKBP1A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
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|
G |
Flcn |
folliculin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FLCN mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
|
|
G |
Fndc11 |
fibronectin type III domain containing 11 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FNDC11 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:168,330,607...168,333,111
Ensembl chr 3:168,330,602...168,334,617
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FOS mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FOSB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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|
G |
Foxa3 |
forkhead box A3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FOXA3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:78,662,067...78,672,321
Ensembl chr 1:78,662,431...78,672,155
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|
G |
Foxj1 |
forkhead box J1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FOXJ1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:101,566,299...101,570,249
Ensembl chr10:101,566,304...101,570,237
|
|
G |
Frg1 |
FSHD region gene 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FRG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:50,925,783...50,946,661
Ensembl chr16:50,925,803...50,946,661
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|
G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]] |
CTD |
PMID:22285649 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
|
|
G |
Fshr |
follicle stimulating hormone receptor |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA] |
CTD |
PMID:22285649 |
|
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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|
G |
Fstl1 |
follistatin-like 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of FSTL1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677
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|
G |
Ftcd |
formimidoyltransferase cyclodeaminase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of FTCD mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735
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|
G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
Disulfiram results in increased expression of FTL mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression |
ISO |
Disulfiram results in increased expression of G6PD mRNA |
CTD |
PMID:20566472 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GADD45B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
|
|
G |
Galnt10 |
polypeptide N-acetylgalactosaminyltransferase 10 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GALNT10 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:41,821,216...41,967,618
Ensembl chr10:41,820,158...41,967,013
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|
G |
Gas6 |
growth arrest specific 6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GAS6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
|
|
G |
Gata2 |
GATA binding protein 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GATA2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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|
G |
Gbp4 |
guanylate binding protein 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GBP4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
|
|
G |
Gcc1 |
GRIP and coiled-coil domain containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GCC1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663
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|
G |
Gcgr |
glucagon receptor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GCGR mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
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|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
Disulfiram results in increased expression of GCLC mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
Disulfiram results in increased expression of GCLM mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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|
G |
Gem |
GTP binding protein overexpressed in skeletal muscle |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GEM mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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|
G |
Gemin6 |
gem (nuclear organelle) associated protein 6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GEMIN6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:14,786,086...14,790,631
Ensembl chr 6:14,786,070...14,790,612
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|
G |
Gh1 |
growth hormone 1 |
multiple interactions |
EXP |
GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B1 mRNA]; GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA] |
CTD |
PMID:8390837 |
|
NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
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|
G |
Glg1 |
golgi glycoprotein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GLG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
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|
G |
Glrx2 |
glutaredoxin 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GLRX2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831
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|
G |
Gosr2 |
golgi SNAP receptor complex member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GOSR2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625
|
|
G |
Gpsm1 |
G-protein signaling modulator 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GPSM1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:9,140,816...9,167,828
Ensembl chr 3:9,128,636...9,167,827
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|
G |
Gpt2 |
glutamic--pyruvic transaminase 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GPT2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
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|
G |
Gpx3 |
glutathione peroxidase 3 |
increases expression |
ISO |
Disulfiram results in increased expression of GPX3 mRNA |
CTD |
PMID:20566472 |
|
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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|
G |
Gramd1a |
GRAM domain containing 1A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GRAMD1A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:86,367,001...86,393,348
Ensembl chr 1:86,367,001...86,393,336
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|
G |
Gramd2b |
GRAM domain containing 2B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GRAMD2B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:49,884,014...49,981,955
Ensembl chr18:49,884,014...49,981,953
|
|
G |
Grwd1 |
glutamate-rich WD repeat containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GRWD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:96,301,260...96,306,962
Ensembl chr 1:96,301,261...96,307,201
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|
G |
Gsdmd |
gasdermin D |
multiple interactions decreases cleavage |
ISO |
Disulfiram binds to and results in decreased activity of GSDMD protein; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of GSDMD protein] Disulfiram results in decreased cleavage of GSDMD protein |
CTD |
PMID:32367036 PMID:33851234 |
|
NCBI chr 7:107,542,242...107,547,052
Ensembl chr 7:107,542,083...107,547,055
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|
G |
Gsdme |
gasdermin E |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of GSDME mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
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|
G |
Gsr |
glutathione-disulfide reductase |
increases expression |
ISO |
Disulfiram results in increased expression of GSR mRNA |
CTD |
PMID:20566472 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
|
|
G |
Gtf2b |
general transcription factor IIB |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of GTF2B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
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|
G |
H2ac20 |
H2A clustered histone 20 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of H2AC20 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:183,779,879...183,780,324
|
|
G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein]; Disulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] |
CTD |
PMID:28300663 PMID:35279910 |
|
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
|
|
G |
H2bc12 |
H2B clustered histone 12 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of H2BC12 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr17:42,485,746...42,486,126
|
|
G |
H2bc8 |
H2B clustered histone 8 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of H2BC8 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr17:42,708,646...42,709,435
|
|
G |
H3f4 |
H3.4 histone, cluster member |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of H3-4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:43,740,797...43,741,207
|
|
G |
H6pd |
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of H6PD mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
|
|
G |
Hba-a2 |
hemoglobin alpha, adult chain 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HBA1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
|
|
G |
Hbegf |
heparin-binding EGF-like growth factor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HBEGF mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
|
|
G |
Hes1 |
hes family bHLH transcription factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HES1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
|
|
G |
Hes6 |
hes family bHLH transcription factor 6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HES6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:92,001,838...92,003,580
Ensembl chr 9:92,001,841...92,003,559
|
|
G |
Hist1h3b |
histone cluster 1, H3b |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of H3C12 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr17:42,722,805...42,723,925
Ensembl chr17:42,723,450...42,723,911
|
|
G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
Disulfiram results in increased expression of HMOX1 mRNA [Disulfiram binds to Copper] which results in decreased expression of HMOX1 mRNA; [Disulfiram co-treated with Zinc Sulfate] results in increased expression of HMOX1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA] |
CTD |
PMID:20566472 PMID:24690739 PMID:32661532 PMID:32712770 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hnrnpa2b1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of HNRNPA2B1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
|
|
G |
Hoxa1 |
homeobox A1 |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA] |
CTD |
PMID:23696197 |
|
NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504
|
|
G |
Hoxd1 |
homeo box D1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HOXD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:59,665,629...59,667,769
Ensembl chr 3:59,665,629...59,667,769
|
|
G |
Hrk |
harakiri, BCL2 interacting protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HRK mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:38,387,484...38,409,652
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|
G |
Hs3st2 |
heparan sulfate-glucosamine 3-sulfotransferase 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HS3ST2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:175,956,161...176,077,400
Ensembl chr 1:175,956,157...176,077,399
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|
G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
multiple interactions |
ISO |
[Disulfiram co-treated with NAD] binds to HSD11B1 protein |
CTD |
PMID:25526675 |
|
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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|
G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases activity |
ISO |
Disulfiram results in decreased activity of HSD11B2 protein |
CTD |
PMID:22796344 |
|
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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|
G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSP90AA1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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|
G |
Hsp90ab1 |
heat shock protein 90 alpha family class B member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSP90AB1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
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|
G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression multiple interactions |
ISO |
Disulfiram results in increased expression of HSPA1B mRNA [Disulfiram binds to Copper] which results in decreased expression of HSPA1B mRNA |
CTD |
PMID:20566472 PMID:24690739 |
|
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
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|
G |
Hspa1b |
heat shock protein family A (Hsp70) member 1B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPA1A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:3,870,765...3,873,221
|
|
G |
Hspa1l |
heat shock protein family A (Hsp70) member 1 like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPA1L mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
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|
G |
Hspa4 |
heat shock protein family A (Hsp70) member 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPA4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
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|
G |
Hspa6l-ps1 |
heat shock protein family A (Hsp70) member 6 like, pseudogene 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPA6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:83,271,340...83,275,267
|
|
G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPA8 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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|
G |
Hspb1 |
heat shock protein family B (small) member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPB1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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|
G |
Hspb8 |
heat shock protein family B (small) member 8 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPB8 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
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|
G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of HSPH1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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|
G |
Htr2b |
5-hydroxytryptamine receptor 2B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of HTR2B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
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|
G |
Id2 |
inhibitor of DNA binding 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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|
G |
Ier5 |
immediate early response 5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of IER5 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:67,270,134...67,272,226
Ensembl chr13:67,270,135...67,272,227
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|
G |
Ifit2 |
interferon-induced protein with tetratricopeptide repeats 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IFIT2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
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|
G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IFIT3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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|
G |
Ifngr2 |
interferon gamma receptor 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IFNGR2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
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|
G |
Igf2r |
insulin-like growth factor 2 receptor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IGF2R mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
|
|
G |
Igfbp7 |
insulin-like growth factor binding protein 7 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IGFBP7 mRNA; [Disulfiram binds to Copper] which results in increased expression of IGFBP7 protein |
CTD |
PMID:24690739 |
|
NCBI chr14:30,737,414...30,797,317
Ensembl chr14:30,737,164...30,797,314
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|
G |
Il18 |
interleukin 18 |
multiple interactions |
ISO |
[Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein] |
CTD |
PMID:33579316 PMID:33851234 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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|
G |
Il1a |
interleukin 1 alpha |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IL1A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IL1B mRNA; [Disulfiram co-treated with Adenosine Triphosphate] inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; Disulfiram inhibits the reaction [Nigericin results in increased secretion of IL1B protein] Disulfiram inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:24690739 PMID:32367036 PMID:32712770 PMID:33579316 PMID:33851234 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of IL6 mRNA; [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL6 protein] |
CTD |
PMID:24690739 PMID:32712770 PMID:33851234 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Insig1 |
insulin induced gene 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of INSIG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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|
G |
Irf8 |
interferon regulatory factor 8 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of IRF8 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:48,790,483...48,812,363
Ensembl chr19:48,790,588...48,811,829
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|
G |
Isy1 |
ISY1 splicing factor homolog |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ISY1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188
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|
G |
Itga11 |
integrin subunit alpha 11 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ITGA11 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:63,145,950...63,254,717
Ensembl chr 8:63,146,001...63,254,407
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|
G |
Itga3 |
integrin subunit alpha 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ITGA3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
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|
G |
Itgam |
integrin subunit alpha M |
increases expression |
ISO |
Disulfiram results in increased expression of ITGAM protein |
CTD |
PMID:32712770 |
|
NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
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|
G |
Itgav |
integrin subunit alpha V |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ITGAV mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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|
G |
Itgb1 |
integrin subunit beta 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ITGB1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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|
G |
Itgb5 |
integrin subunit beta 5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of ITGB5 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472
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|
G |
Jag2 |
jagged canonical Notch ligand 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of JAG2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:131,983,056...132,005,359
Ensembl chr 6:131,983,056...132,005,818
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|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased expression of and results in increased phosphorylation of JUN protein; [Copper co-treated with Disulfiram] results in increased expression of and results in increased phosphorylation of JUN protein; [Disulfiram co-treated with cupric chloride co-treated with Doxorubicin] results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [[Copper co-treated with Disulfiram] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Disulfiram co-treated with Copper co-treated with Doxorubicin] results in increased phosphorylation of and results in increased expression of JUN protein] |
CTD |
PMID:21911303 PMID:23033007 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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|
G |
Kcng1 |
potassium voltage-gated channel modifier subfamily G member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of KCNG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:156,960,717...156,992,877
Ensembl chr 3:156,973,156...156,992,635
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|
G |
Khdrbs3 |
KH RNA binding domain containing, signal transduction associated 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of KHDRBS3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:100,837,707...100,995,644
Ensembl chr 7:100,837,934...100,988,460
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|
G |
Klf10 |
KLF transcription factor 10 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of KLF10 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994
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|
G |
Klhl22 |
kelch-like family member 22 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of KLHL22 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:83,190,891...83,231,746
Ensembl chr11:83,190,891...83,231,770
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|
G |
Klhl5 |
kelch-like family member 5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of KLHL5 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:43,144,254...43,206,192
Ensembl chr14:43,144,257...43,184,238
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|
G |
Krt75 |
keratin 75 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of KRT75 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345
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|
G |
Lamc1 |
laminin subunit gamma 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of LAMC1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
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|
G |
Lamtor3 |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of LAMTOR3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
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|
G |
Lemd2 |
LEM domain nuclear envelope protein 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of LEMD2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626
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|
G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of BMP7 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CCND2 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP17A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of CYP19A1 mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of FSHR mRNA]; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]] |
CTD |
PMID:22285649 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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|
G |
Lhcgr |
luteinizing hormone/choriogonadotropin receptor |
multiple interactions |
ISO |
Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]] |
CTD |
PMID:22285649 |
|
NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
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|
G |
Limch1 |
LIM and calponin homology domains 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of LIMCH1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:41,112,579...41,425,185
Ensembl chr14:41,114,803...41,425,191
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|
G |
Lipt1 |
lipoyltransferase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of LIPT1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:40,107,938...40,118,268
Ensembl chr 9:40,098,615...40,113,565
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|
G |
Lmcd1 |
LIM and cysteine-rich domains 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of LMCD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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|
G |
Lmtk2 |
lemur tyrosine kinase 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of LMTK2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:10,426,772...10,508,750
Ensembl chr12:10,426,777...10,508,750
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|
G |
LOC100361693 |
zinc finger protein 53-like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ZNF34 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:157,509,762...157,513,970
Ensembl chr 5:157,509,451...157,599,926
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|
G |
LOC100910577 |
zinc finger protein 709-like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of ZNF77 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:7,269,879...7,316,286
Ensembl chr 7:7,269,927...7,286,051
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|
G |
LOC685680 |
similar to TPA-induced transmembrane protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of C3ORF52 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:55,166,986...55,192,273
Ensembl chr11:55,166,678...55,192,292
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|
G |
Loricrin |
loricrin cornified envelope precursor protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of LORICRIN mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:177,558,062...177,559,980
Ensembl chr 2:177,558,252...177,559,807
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|
G |
Lratd2 |
LRAT domain containing 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of LRATD2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:92,376,713...92,387,045
Ensembl chr 7:92,362,194...92,388,189
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|
G |
Lrp8 |
LDL receptor related protein 8 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of LRP8 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352
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|
G |
Lsmem1 |
leucine-rich single-pass membrane protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of LSMEM1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:57,250,221...57,262,240
Ensembl chr 6:57,252,056...57,261,653
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|
G |
Ltb4r |
leukotriene B4 receptor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:29,263,126...29,265,716
|
|
G |
Luc7l3 |
LUC7-like 3 pre-mRNA splicing factor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of CROP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:79,240,050...79,276,555
Ensembl chr10:79,240,563...79,276,538
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|
G |
Macf1 |
microtubule-actin crosslinking factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of MACF1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:135,623,729...135,949,097
Ensembl chr 5:135,623,742...135,945,905
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|
G |
Mad2l1bp |
MAD2L1 binding protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAD2L1BP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447
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|
G |
Mafb |
MAF bZIP transcription factor B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAFB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
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G |
Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
Disulfiram results in increased expression of MAFF mRNA |
CTD |
PMID:20566472 |
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NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
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G |
Mafg |
MAF bZIP transcription factor G |
increases expression |
ISO |
Disulfiram results in increased expression of MAFG mRNA |
CTD |
PMID:20566472 |
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NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
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G |
Mafk |
MAF bZIP transcription factor K |
increases expression |
ISO |
Disulfiram results in increased expression of MAFK mRNA |
CTD |
PMID:20566472 |
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NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048 Ensembl chr12:14,833,984...14,837,048
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G |
Magoh |
mago homolog, exon junction complex subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAGOH mRNA |
CTD |
PMID:24690739 |
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NCBI chr 5:122,639,268...122,646,650
Ensembl chr 5:122,639,308...122,646,617
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G |
Man1b1 |
mannosidase, alpha, class 1B, member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of MAN1B1 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 3:8,143,877...8,165,007
Ensembl chr 3:8,143,381...8,165,006
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G |
Maoa |
monoamine oxidase A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAOA mRNA |
CTD |
PMID:24690739 |
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NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAP1LC3B mRNA |
CTD |
PMID:24690739 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2k3 |
mitogen activated protein kinase kinase 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAP2K3 mRNA |
CTD |
PMID:24690739 |
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NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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G |
Map3k13 |
mitogen-activated protein kinase kinase kinase 13 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAP3K13 mRNA |
CTD |
PMID:24690739 |
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NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
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G |
Map3k20 |
mitogen-activated protein kinase kinase kinase 20 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of MAP3K20 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK1 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK1 protein |
CTD |
PMID:23033007 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[Copper co-treated with Disulfiram co-treated with Gemcitabine] results in increased phosphorylation of MAPK3 protein; [Copper co-treated with Disulfiram] results in increased phosphorylation of MAPK3 protein |
CTD |
PMID:23033007 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP ISO |
[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein] [Disulfiram binds to Copper] which results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:11239917 PMID:24690739 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:24690739 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mapre2 |
microtubule-associated protein, RP/EB family, member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MAPRE2 mRNA |
CTD |
PMID:24690739 |
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NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044
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G |
Mcm2 |
minichromosome maintenance complex component 2 |
multiple interactions decreases expression |
ISO |
cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM2 mRNA] |
CTD |
PMID:19789329 |
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NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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G |
Mcm5 |
minichromosome maintenance complex component 5 |
multiple interactions decreases expression |
ISO |
cupric chloride promotes the reaction [Disulfiram results in decreased expression of MCM5 mRNA] |
CTD |
PMID:19789329 |
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NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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G |
Me1 |
malic enzyme 1 |
increases expression |
ISO |
Disulfiram results in increased expression of ME1 mRNA |
CTD |
PMID:20566472 |
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NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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G |
Mfsd3 |
major facilitator superfamily domain containing 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of MFSD3 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 7:108,419,644...108,423,469
Ensembl chr 7:108,421,350...108,423,461
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases activity multiple interactions increases degradation |
EXP ISO |
Disulfiram results in decreased activity of MGMT protein [Disulfiram binds to Copper] which results in decreased expression of and results in decreased activity of MGMT protein; [Disulfiram co-treated with cupric chloride] affects the expression of and affects the activity of MGMT protein; bortezomib inhibits the reaction [Disulfiram results in increased degradation of MGMT protein]; Disulfiram inhibits the reaction [O(6)-benzylguanine binds to MGMT protein]; Disulfiram results in decreased expression of and results in decreased activity of MGMT protein |
CTD |
PMID:24193513 |
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NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
Disulfiram results in increased expression of MGST1 mRNA |
CTD |
PMID:20566472 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Midn |
midnolin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MIDN mRNA |
CTD |
PMID:24690739 |
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NCBI chr 7:9,548,100...9,559,605
Ensembl chr 7:9,549,650...9,559,752
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G |
Mix23 |
mitochondrial matrix import factor 23 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MIX23 mRNA |
CTD |
PMID:24690739 |
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NCBI chr11:64,660,711...64,681,000
Ensembl chr11:64,660,711...64,681,000
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G |
Mmp10 |
matrix metallopeptidase 10 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MMP10 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
Disulfiram results in decreased expression of MMP2 |
CTD |
PMID:18047805 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
Disulfiram results in decreased expression of MMP9 |
CTD |
PMID:18047805 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mppe1 |
metallophosphoesterase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of MPPE1 mRNA |
CTD |
PMID:24690739 |
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NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553
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G |
Mrpl10 |
mitochondrial ribosomal protein L10 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MRPL10 mRNA |
CTD |
PMID:24690739 |
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NCBI chr10:82,026,031...82,034,451
Ensembl chr10:82,026,031...82,034,443
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G |
Mrpl18 |
mitochondrial ribosomal protein L18 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MRPL18 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 1:47,837,169...47,841,987
Ensembl chr 1:47,836,561...47,841,987
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G |
Mrpl45 |
mitochondrial ribosomal protein L45 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MRPL45 mRNA |
CTD |
PMID:24690739 |
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NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
affects activity affects expression |
EXP |
Disulfiram affects the activity of COX1 protein Disulfiram affects the expression of COX1 mRNA |
CTD |
PMID:17936468 |
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NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MT1A mRNA |
CTD |
PMID:24690739 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
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G |
Mt2A |
metallothionein 2A |
increases expression multiple interactions |
ISO |
Disulfiram results in increased expression of MT2A mRNA cupric chloride promotes the reaction [Disulfiram results in increased expression of MT2A mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA] |
CTD |
PMID:19789329 PMID:32661532 |
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NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mt3 |
metallothionein 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MT3 mRNA |
CTD |
PMID:24690739 |
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NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MTF1 mRNA; MTF1 protein affects the reaction [Disulfiram results in increased expression of ATF3 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of HMOX1 mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT1M mRNA]; MTF1 protein affects the reaction [Disulfiram results in increased expression of MT2A mRNA] |
CTD |
PMID:24690739 PMID:32661532 |
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NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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G |
Mx1 |
MX dynamin like GTPase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of MX1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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G |
Mylip |
myosin regulatory light chain interacting protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of MYLIP mRNA |
CTD |
PMID:24690739 |
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NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295
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G |
Mylk |
myosin light chain kinase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of MYLK mRNA |
CTD |
PMID:24690739 |
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NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Nat14 |
N-acetyltransferase 14 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NAT14 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 1:68,910,599...68,913,452
Ensembl chr 1:68,910,601...68,912,733
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G |
Nceh1 |
neutral cholesterol ester hydrolase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NCEH1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
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G |
Ncoa7 |
nuclear receptor coactivator 7 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NCOA7 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:26,856,228...27,016,950
Ensembl chr 1:26,856,530...27,015,871
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G |
Ncstn |
nicastrin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NCSTN mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
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G |
Nefh |
neurofilament heavy chain |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NEFH mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G |
Nfe2l3 |
NFE2 like bZIP transcription factor 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NFE2L3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:80,506,756...80,534,629
Ensembl chr 4:80,506,756...80,534,629
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NFKB1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
decreases degradation multiple interactions |
EXP ISO |
Disulfiram results in decreased degradation of NFKBIA protein [Disulfiram binds to Copper] which results in increased expression of NFKBIA protein |
CTD |
PMID:10418820 PMID:24690739 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nfkbib |
NFKB inhibitor beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NFKBIB protein |
CTD |
PMID:24690739 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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G |
Ngdn |
neuroguidin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NGDN mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:28,489,950...28,497,286
Ensembl chr15:28,490,040...28,519,654
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G |
Niban1 |
niban apoptosis regulator 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NIBAN1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729
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G |
Nol12 |
nucleolar protein 12 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NOL12 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:110,493,294...110,498,908
Ensembl chr 7:110,493,246...110,498,907
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G |
Nos2 |
nitric oxide synthase 2 |
affects expression |
EXP |
Disulfiram affects the expression of NOS2 mRNA |
CTD |
PMID:17936468 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nosip |
nitric oxide synthase interacting protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NOSIP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:95,543,329...95,559,101
Ensembl chr 1:95,543,360...95,558,650
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G |
Npepl1 |
aminopeptidase-like 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NPEPL1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:162,893,891...162,906,492
Ensembl chr 3:162,893,943...162,906,492
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G |
Nppb |
natriuretic peptide B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NPPB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nptx2 |
neuronal pentraxin 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NPTX2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:10,037,435...10,048,345
Ensembl chr12:10,037,435...10,048,345
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression increases activity |
ISO EXP |
Disulfiram results in increased expression of NQO1 mRNA Disulfiram results in increased activity of NQO1 protein |
CTD |
PMID:16045903 PMID:20566472 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
Disulfiram binds to and affects the activity of NR1I2 protein Disulfiram binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:33049310 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nrarp |
Notch-regulated ankyrin repeat protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NRARP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:7,992,582...7,995,136
Ensembl chr 3:7,992,552...7,995,133
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G |
Nras |
NRAS proto-oncogene, GTPase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NRAS mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
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G |
Nrp1 |
neuropilin 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NRP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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G |
Nt5e |
5' nucleotidase, ecto |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of NT5E mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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G |
Nubp1 |
NUBP iron-sulfur cluster assembly factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NUBP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:5,260,237...5,270,835
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G |
Nxf1 |
nuclear RNA export factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NXF1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:205,655,442...205,668,637
Ensembl chr 1:205,655,375...205,668,636
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G |
Nxt2 |
nuclear transport factor 2-like export factor 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of NXT2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr X:105,855,616...105,862,902
Ensembl chr X:105,855,608...105,862,899
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G |
Oasl |
2'-5'-oligoadenylate synthetase-like |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of OASL mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
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G |
Osmr |
oncostatin M receptor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of OSMR mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:55,907,119...55,961,373
Ensembl chr 2:55,907,132...55,961,262
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G |
P3h3 |
prolyl 3-hydroxylase 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of P3H3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:157,646,238...157,662,035
Ensembl chr 4:157,646,243...157,695,509
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G |
P3h4 |
prolyl 3-hydroxylase family member 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of P3H4 mRNA |
CTD |
PMID:24690739 |
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NCBI chr10:85,338,158...85,345,108
Ensembl chr10:85,338,161...85,345,093
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G |
Pam |
peptidylglycine alpha-amidating monooxygenase |
increases activity |
EXP |
Disulfiram results in increased activity of PAM protein |
CTD |
PMID:8246921 PMID:10347250 |
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NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[Copper co-treated with Disulfiram] results in increased cleavage of PARP1 protein; [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein; [Disulfiram co-treated with cupric chloride] results in increased cleavage of PARP1 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of PARP1 protein] Disulfiram results in increased cleavage of PARP1 protein |
CTD |
PMID:17079463 PMID:19789329 PMID:23033007 PMID:24193513 PMID:24690739 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pck2 |
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PCK2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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G |
Pcnx4 |
pecanex 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PCNX4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:91,125,063...91,170,423
Ensembl chr 6:91,125,063...91,170,439
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G |
Pde5a |
phosphodiesterase 5A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PDE5A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
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G |
Pdlim5 |
PDZ and LIM domain 5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PDLIM5 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
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G |
Pdpn |
podoplanin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PDPN protein [Disulfiram binds to Copper] which results in increased expression of and results in increased phosphorylation of and results in increased ubiquitination of PDPN protein |
CTD |
PMID:24690739 |
|
NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
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G |
Pdrg1 |
p53 and DNA damage regulated 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PDRG1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858 Ensembl chr 3:141,476,501...141,483,858
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G |
Pgd |
phosphogluconate dehydrogenase |
increases expression |
ISO |
Disulfiram results in increased expression of PGD mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
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G |
Phlda2 |
pleckstrin homology-like domain, family A, member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PHLDA2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:198,696,897...198,699,292
Ensembl chr 1:198,696,897...198,697,836
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G |
Phldb2 |
pleckstrin homology-like domain, family B, member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PHLDB2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467
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G |
Pigq |
phosphatidylinositol glycan anchor biosynthesis, class Q |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PIGQ mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:14,942,571...14,958,584
Ensembl chr10:14,942,577...14,958,584
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G |
Pik3ip1 |
phosphoinositide-3-kinase interacting protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PIK3IP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:78,203,539...78,216,616
Ensembl chr14:78,204,053...78,216,608
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G |
Pip4k2a |
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PIP4K2A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029
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G |
Plod2 |
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PLOD2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255
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G |
Plpbp |
pyridoxal phosphate binding protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PLPBP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886
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G |
Plscr4 |
phospholipid scramblase 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PLSCR4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:92,987,290...93,026,056
Ensembl chr 8:92,987,381...93,026,049
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G |
Plxnb2 |
plexin B2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PLXNB2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:120,232,276...120,258,385
Ensembl chr 7:120,232,331...120,258,330
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G |
Pnldc1 |
PARN like ribonuclease domain containing exonuclease 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PNLDC1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:47,843,224...47,861,675
Ensembl chr 1:47,843,224...47,861,674
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G |
Pnma2 |
PNMA family member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PNMA2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:41,111,942...41,119,649
Ensembl chr15:41,112,009...41,121,427
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G |
Polr2c |
RNA polymerase II subunit C |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of POLR2C mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:10,158,153...10,164,935
Ensembl chr19:10,157,823...10,164,945
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G |
Polr2m |
RNA polymerase II subunit M |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of POLR2M mRNA |
CTD |
PMID:24690739 |
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NCBI chr 8:72,131,992...72,139,423
Ensembl chr 8:72,131,530...72,243,036
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G |
Pomc |
proopiomelanocortin |
decreases expression |
EXP |
Disulfiram results in decreased expression of POMC protein alternative form |
CTD |
PMID:8246921 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Pop4 |
POP4 homolog, ribonuclease P/MRP subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of POP4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:90,960,026...90,968,360
Ensembl chr 1:90,960,022...90,968,443
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G |
Postn |
periostin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of POSTN mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions affects expression |
ISO |
Disulfiram binds to and results in increased activity of PPARG protein Disulfiram affects the expression of PPARG mRNA |
CTD |
PMID:32712770 PMID:33049310 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppia |
peptidylprolyl isomerase A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PPIA mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PPP1R15A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Ppp1r3c |
protein phosphatase 1, regulatory subunit 3C |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PPP1R3C mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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G |
Ppp2r2b |
protein phosphatase 2, regulatory subunit B, beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PPP2R2B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
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G |
Prok2 |
prokineticin 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PROK2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385
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G |
Prss8 |
serine protease 8 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
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G |
Psat1 |
phosphoserine aminotransferase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PSAT1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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G |
Psmc4 |
proteasome 26S subunit, ATPase 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PSMC4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
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G |
Pspn |
persephin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PSPN mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:1,841,105...1,841,663
Ensembl chr 9:1,840,896...1,854,327
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
[Copper co-treated with Disulfiram] results in decreased expression of PTEN protein |
CTD |
PMID:20424113 |
|
NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptges3 |
prostaglandin E synthase 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PTGES3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
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G |
Ptgr1 |
prostaglandin reductase 1 |
increases expression |
ISO |
Disulfiram results in increased expression of PTGR1 mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression |
EXP |
Disulfiram results in decreased expression of PTGS2 mRNA |
CTD |
PMID:10418820 |
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NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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G |
Ptma |
prothymosin alpha |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of PTMA mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
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G |
Ptx3 |
pentraxin 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of PTX3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
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G |
Rab5c |
RAB5C, member RAS oncogene family |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RAB5C mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:85,642,553...85,666,142
Ensembl chr10:85,642,809...85,666,103
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G |
Rac1 |
Rac family small GTPase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RAC1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Rai2 |
retinoic acid induced 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RAI2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr X:32,948,656...33,011,222
Ensembl chr X:32,948,656...33,011,264
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G |
Ramac |
RNA guanine-7 methyltransferase activating subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RAMAC mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:135,708,529...135,714,417
Ensembl chr 1:135,708,535...135,722,151
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G |
Rasa1 |
RAS p21 protein activator 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RASA1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
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G |
Rasd1 |
ras related dexamethasone induced 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RASD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
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G |
Rasl11b |
RAS-like family 11 member B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RASL11B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:34,014,924...34,019,146
Ensembl chr14:34,014,509...34,019,152
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G |
Rbis |
ribosomal biogenesis factor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RBIS mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339
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G |
Rbm18 |
RNA binding motif protein 18 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RBM18 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:19,467,333...19,487,171
Ensembl chr 3:19,467,335...19,487,178
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G |
Rbm48 |
RNA binding motif protein 48 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RBM48 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:30,559,063...30,569,409
Ensembl chr 4:30,559,087...30,569,406
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G |
Rep15 |
RAB15 effector protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of REP15 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:179,951,935...179,953,008
Ensembl chr 4:179,951,935...179,953,008
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G |
Rftn1 |
raftlin lipid raft linker 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RFTN1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084
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G |
Rftn2 |
raftlin family member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RFTN2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:56,651,617...56,707,830
Ensembl chr 9:56,630,460...56,707,810
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G |
Rgcc |
regulator of cell cycle |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RGCC mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
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G |
RGD1306746 |
similar to Hypothetical protein MGC25529 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of C2ORF42 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:118,887,688...118,916,808
Ensembl chr 4:118,888,112...118,916,936
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G |
RGD1310553 |
similar to expressed sequence AI597479 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of C2ORF49 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 9:45,371,396...45,382,123
Ensembl chr 9:45,371,430...45,382,120
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G |
RGD1564664 |
similar to LOC387763 protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of C11ORF96 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:79,920,131...79,921,523
Ensembl chr 3:79,920,129...79,921,523
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G |
Rgs11 |
regulator of G-protein signaling 11 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RGS11 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:15,222,803...15,231,060
Ensembl chr10:15,222,803...15,231,060
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G |
Rgs16 |
regulator of G-protein signaling 16 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RGS16 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:65,887,788...65,891,232
Ensembl chr13:65,887,530...65,892,857
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G |
Rgs2 |
regulator of G-protein signaling 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RGS2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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G |
Rhbdf1 |
rhomboid 5 homolog 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RHBDF1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763
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G |
Rhbdf2 |
rhomboid 5 homolog 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RHBDF2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283
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G |
Rhob |
ras homolog family member B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RHOB mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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G |
Rnf207 |
ring finger protein 207 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RNF207 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:162,815,351...162,828,325
Ensembl chr 5:162,815,357...162,828,375
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G |
Rpl23 |
ribosomal protein L23 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RPL23 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870
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G |
Rpl29 |
ribosomal protein L29 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RPL29 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:107,068,929...107,070,963
Ensembl chr 8:107,068,480...107,070,914
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G |
Rpl38 |
ribosomal protein L38 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RPL38 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:99,701,330...99,705,004
Ensembl chr10:99,701,362...99,705,004
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G |
Rps15 |
ribosomal protein S15 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RPS15 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
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G |
Rps7 |
ribosomal protein S7 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RPS7 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
|
|
G |
Rrad |
RRAD, Ras related glycolysis inhibitor and calcium channel regulator |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RRAD mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
|
|
G |
Rragd |
Ras-related GTP binding D |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RRAGD mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
|
|
G |
Rras |
RAS related |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RRAS mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357
|
|
G |
Rsad2 |
radical S-adenosyl methionine domain containing 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of RSAD2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
|
|
G |
RT1-CE5 |
RT1 class I, locus CE5 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of HLA-F mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:3,403,418...3,479,476
|
|
G |
Runx2 |
RUNX family transcription factor 2 |
increases expression |
EXP |
Disulfiram results in increased expression of RUNX2 mRNA |
CTD |
PMID:24496638 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
|
|
G |
Rybp |
RING1 and YY1 binding protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of RYBP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:132,876,361...132,927,580 NCBI chr 4:132,876,260...132,929,075
Ensembl chr 4:132,876,361...132,928,316
|
|
G |
Sap18 |
Sin3A associated protein 18 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SAP18 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:31,943,228...31,947,534
Ensembl chr15:31,943,230...31,950,038
|
|
G |
Sar1b |
secretion associated, Ras related GTPase 1B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SAR1B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:36,024,443...36,054,067
Ensembl chr10:36,024,382...36,054,066
|
|
G |
Sat1 |
spermidine/spermine N1-acetyl transferase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SAT1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
|
|
G |
Sbds |
Sbds, ribosome maturation factor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SBDS mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:26,420,410...26,429,650
Ensembl chr12:26,420,414...26,429,649
|
|
G |
Scarf2 |
scavenger receptor class F, member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SCARF2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:83,175,956...83,187,415
Ensembl chr11:83,175,963...83,187,348
|
|
G |
Sec61b |
SEC61 translocon subunit beta |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SEC61B mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
|
|
G |
Sel1l3 |
SEL1L family member 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SEL1L3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644
|
|
G |
Sem1 |
SEM1 26S proteasome subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SEM1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 4:34,671,848...34,692,005
Ensembl chr 4:34,671,848...34,692,005
|
|
G |
Sertad1 |
SERTA domain containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SERTAD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
|
|
G |
Sf3b4 |
splicing factor 3B subunit 4 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SF3B4 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:183,732,791...183,737,545
Ensembl chr 2:183,732,754...183,737,959
|
|
G |
Sgta |
small glutamine rich tetratricopeptide repeat co-chaperone alpha |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SGTA mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458
|
|
G |
Sh3pxd2a |
SH3 and PX domains 2A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SH3PXD2A mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166
|
|
G |
Sik1 |
salt-inducible kinase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SIK1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
|
|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SIRT1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
|
|
G |
Sirt6 |
sirtuin 6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SIRT6 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914
|
|
G |
Ski |
Ski proto-oncogene |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SKI mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:165,713,525...165,782,134
Ensembl chr 5:165,714,093...165,782,733
|
|
G |
Skil |
SKI-like proto-oncogene |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SKIL mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
|
|
G |
Slc16a10 |
solute carrier family 16 member 10 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SLC16A10 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
|
|
G |
Slc25a37 |
solute carrier family 25 member 37 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SLC25A37 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
|
|
G |
Slc30a1 |
solute carrier family 30 member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SLC30A1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
|
|
G |
Slc44a1 |
solute carrier family 44 member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SLC44A1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:68,061,941...68,241,912
Ensembl chr 5:68,063,618...68,241,909
|
|
G |
Slc44a2 |
solute carrier family 44 member 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SLC44A2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:19,870,867...19,905,345
Ensembl chr 8:19,870,888...19,905,342
|
|
G |
Slc6a9 |
solute carrier family 6 member 9 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SLC6A9 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
|
|
G |
Slc7a1 |
solute carrier family 7 member 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SLC7A1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:6,628,214...6,703,849
Ensembl chr12:6,628,007...6,703,849
|
|
G |
Slc7a6os |
solute carrier family 7, member 6 opposite strand |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SLC7A6OS mRNA |
CTD |
PMID:24690739 |
|
NCBI chr19:34,101,978...34,110,666
Ensembl chr19:34,101,982...34,110,651
|
|
G |
Slfn13 |
schlafen family member 13 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SLFN11 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:67,909,105...67,955,912
Ensembl chr10:67,909,106...67,925,383
|
|
G |
Slu7 |
SLU7 homolog, splicing factor |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SLU7 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349
|
|
G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
|
|
G |
Smox |
spermine oxidase |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SMOX mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
|
|
G |
Snai1 |
snail family transcriptional repressor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
|
|
G |
Snip1 |
Smad nuclear interacting protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SNIP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:137,328,371...137,335,846
Ensembl chr 5:137,328,371...137,335,845
|
|
G |
Snrpb2 |
small nuclear ribonucleoprotein polypeptide B2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SNRPB2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812
|
|
G |
Sod1 |
superoxide dismutase 1 |
increases expression decreases activity |
ISO |
Disulfiram results in increased expression of SOD1 mRNA Disulfiram results in decreased activity of SOD1 protein |
CTD |
PMID:19016906 PMID:20566472 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO |
Disulfiram results in increased expression of SOD2 mRNA [Disulfiram co-treated with Zinc Sulfate] results in increased expression of SOD2 mRNA |
CTD |
PMID:20566472 PMID:32712770 |
|
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
|
|
G |
Sod3 |
superoxide dismutase 3 |
increases expression |
ISO |
Disulfiram results in increased expression of SOD3 mRNA |
CTD |
PMID:20566472 |
|
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
|
|
G |
Sox8 |
SRY-box transcription factor 8 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SOX8 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:14,584,829...14,589,818
Ensembl chr10:14,584,829...14,589,818
|
|
G |
Spacdr |
sperm acrosome developmental regulator |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SPACDR mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:18,930,608...18,936,787
Ensembl chr12:18,914,398...18,952,008
|
|
G |
Spata20 |
spermatogenesis associated 20 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SPATA20 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:79,427,525...79,435,472
Ensembl chr10:79,427,528...79,434,368
|
|
G |
Spire1 |
spire-type actin nucleation factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SPIRE1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:61,041,290...61,171,670
Ensembl chr18:61,041,290...61,171,899
|
|
G |
Spsb1 |
splA/ryanodine receptor domain and SOCS box containing 1 |
increases expression |
ISO |
Disulfiram results in increased expression of SPSB1 mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
|
|
G |
Sptbn1 |
spectrin, beta, non-erythrocytic 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SPTBN1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr14:103,842,684...104,008,507
Ensembl chr14:103,842,684...104,008,507
|
|
G |
Spty2d1 |
SPT2 chromatin protein domain containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SPTY2D1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:97,531,495...97,549,633
Ensembl chr 1:97,531,508...97,549,581
|
|
G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SREBF1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
|
|
G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
Disulfiram results in increased expression of SRXN1 mRNA |
CTD |
PMID:20566472 |
|
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
|
|
G |
Stc2 |
stanniocalcin 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of STC2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
|
|
G |
Steep1 |
STING1 ER exit protein 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of STEEP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr X:116,087,626...116,114,159
Ensembl chr X:116,060,929...116,114,159
|
|
G |
Stx3 |
syntaxin 3 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of STX3 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
|
|
G |
Sulf1 |
sulfatase 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SULF1 mRNA; [Disulfiram binds to Copper] which results in increased expression of SULF1 protein |
CTD |
PMID:24690739 |
|
NCBI chr 5:6,362,896...6,526,174
Ensembl chr 5:6,362,911...6,525,584
|
|
G |
Sumo2 |
small ubiquitin-like modifier 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SUMO2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513
|
|
G |
Sun1 |
Sad1 and UNC84 domain containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SUN1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr12:15,396,378...15,441,277
Ensembl chr12:15,396,381...15,441,571
|
|
G |
Sun2 |
Sad1 and UNC84 domain containing 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of SUN2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:111,275,374...111,292,565
Ensembl chr 7:111,275,380...111,292,553
|
|
G |
Supt4h1 |
SPT4 homolog, DSIF elongation factor subunit |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SUPT4H1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr10:72,539,323...72,545,582
Ensembl chr10:72,539,382...72,545,831
|
|
G |
Synj1 |
synaptojanin 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SYNJ1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr11:30,192,629...30,269,277
Ensembl chr11:30,192,629...30,269,220
|
|
G |
Szrd1 |
SUZ RNA binding domain containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of SZRD1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 5:153,418,748...153,443,286
Ensembl chr 5:153,418,748...153,443,252
|
|
G |
Taf13 |
TATA-box binding protein associated factor 13 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TAF13 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 2:196,205,219...196,215,882
Ensembl chr 2:196,205,243...196,215,878
|
|
G |
Taf7 |
TATA-box binding protein associated factor 7 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TAF7 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
|
|
G |
Tamalin |
trafficking regulator and scaffold protein tamalin |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TAMALIN mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 7:132,338,900...132,359,519
Ensembl chr 7:132,338,900...132,346,666
|
|
G |
Tanc1 |
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TANC1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:44,099,387...44,335,478
Ensembl chr 3:44,134,016...44,331,627
|
|
G |
Tap2 |
transporter 2, ATP binding cassette subfamily B member |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TAP2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407
|
|
G |
Tapbp |
TAP binding protein |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TAPBP mRNA |
CTD |
PMID:24690739 |
|
NCBI chr20:4,956,937...4,966,191
Ensembl chr20:4,956,937...4,966,181
|
|
G |
Tat |
tyrosine aminotransferase |
multiple interactions |
EXP |
[Ethanol co-treated with Disulfiram] results in increased activity of TAT protein |
CTD |
PMID:9591243 |
|
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
|
|
G |
Tcea2 |
transcription elongation factor A2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TCEA2 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116
|
|
G |
Tcp1 |
t-complex 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TCP1 mRNA |
CTD |
PMID:24690739 |
|
NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839
|
|
G |
Tent5b |
terminal nucleotidyltransferase 5B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TENT5B mRNA |
CTD |
PMID:24690739 |
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NCBI chr 5:145,695,358...145,702,668
Ensembl chr 5:145,695,362...145,706,073
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G |
Tent5c |
terminal nucleotidyltransferase 5C |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TENT5C mRNA |
CTD |
PMID:24690739 |
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NCBI chr 2:187,853,026...187,875,260
Ensembl chr 2:187,853,024...187,894,744
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G |
Tfip11 |
tuftelin interacting protein 11 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TFIP11 mRNA |
CTD |
PMID:24690739 |
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NCBI chr12:44,299,619...44,311,851
Ensembl chr12:44,299,622...44,311,855
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases activity |
ISO |
Disulfiram results in decreased activity of TGFB1 protein |
CTD |
PMID:31652400 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Thap1 |
THAP domain containing 1 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of THAP1 mRNA |
CTD |
PMID:24690739 |
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NCBI chr16:65,905,348...65,909,942
Ensembl chr16:65,904,230...65,909,942
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G |
Them6 |
thioesterase superfamily member 6 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of THEM6 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 7:106,606,570...106,609,747
Ensembl chr 7:106,606,570...106,609,746
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G |
Thra |
thyroid hormone receptor alpha |
multiple interactions |
ISO |
Disulfiram binds to and results in increased activity of THRA protein |
CTD |
PMID:33049310 |
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NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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G |
Ticam2 |
TIR domain containing adaptor molecule 2 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TICAM2 mRNA |
CTD |
PMID:24690739 |
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NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
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G |
Tmem167a |
transmembrane protein 167A |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TMEM167A mRNA |
CTD |
PMID:24690739 |
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NCBI chr 2:21,197,728...21,216,746
Ensembl chr 2:21,197,786...21,212,099
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G |
Tmem175 |
transmembrane protein 175 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TMEM175 mRNA |
CTD |
PMID:24690739 |
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NCBI chr14:1,073,410...1,089,764
Ensembl chr14:1,073,523...1,089,819
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G |
Tmem208 |
transmembrane protein 208 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in decreased expression of TMEM208 mRNA |
CTD |
PMID:24690739 |
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NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183
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G |
Tmem35b |
transmembrane protein 35B |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TMEM35B mRNA |
CTD |
PMID:24690739 |
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NCBI chr 5:139,446,317...139,449,947
Ensembl chr 5:139,444,399...139,449,947
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G |
Tmem42 |
transmembrane protein 42 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TMEM42 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276
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G |
Tmem43 |
transmembrane protein 43 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TMEM43 mRNA |
CTD |
PMID:24690739 |
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NCBI chr 4:123,977,680...123,992,823
Ensembl chr 4:123,977,625...123,992,825
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G |
Tmem44 |
transmembrane protein 44 |
multiple interactions |
ISO |
[Disulfiram binds to Copper] which results in increased expression of TMEM44 mRNA |
CTD |
PMID:24690739 |
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NCBI chr11:70,181,120...70,216,958
Ensembl chr11:70,181,345...70,216,958
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G |
Tnf |
tumor necrosis factor |
decreases expression increases secretion multiple interactions |
EXP ISO |
Disulfiram results in decreased expression of TNF mRNA Disulfiram results in increased secretion of TNF protein [Disulfiram co-treated with Zinc Sulfate] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Disulfiram inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; Disulfiram promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Disulfiram inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased secretion of TNF protein] |
CTD |
PMID:10418820 PMID: | |