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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:non-steroidal anti-inflammatory drug
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Accession:CHEBI:35475 term browser browse the term
Definition:An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
Synonyms:related_synonym: NSAID;   NSAIDs;   non-steroidal anti-inflammatory agent;   non-steroidal anti-inflammatory drugs
 xref: Wikipedia:Non-steroidal_anti-inflammatory_drug


show annotations for term's descendants           Sort by:
 
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
apocynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
EXP acetovanillone inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]
acetovanillone results in decreased expression of CCL2 mRNA
CTD PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP acetovanillone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP acetovanillone inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA] CTD PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
flunixin meglumine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 affects expression EXP flunixin meglumine affects the expression of ABCB1 mRNA CTD PMID:26366864 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects expression EXP flunixin meglumine affects the expression of CYP1A2 mRNA CTD PMID:26366864 NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects expression EXP flunixin meglumine affects the expression of CYP2E1 mRNA CTD PMID:26366864 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
G CYP3A22 cytochrome P450 family 3 subfamily A member 22 affects expression EXP flunixin meglumine affects the expression of CYP3A22 mRNA CTD PMID:26366864 NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817
JBrowse link
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 affects expression EXP flunixin meglumine affects the expression of CYP3A29 mRNA CTD PMID:26366864 NCBI chr 3:6,738,502...6,778,121 JBrowse link
G LOC110262013 sulfotransferase 1 family member D1 affects expression EXP flunixin meglumine affects the expression of SULT1A1 mRNA CTD PMID:26366864 NCBI chr 8:66,762,885...66,789,582 JBrowse link
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression
multiple interactions
EXP Ibuprofen results in decreased expression of NOS3 mRNA
11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 11-deoxyprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; sulprostone inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]
CTD PMID:10525081 PMID:10644584 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Indomethacin affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Indomethacin results in increased expression of DDIT3 mRNA CTD PMID:18799549 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Indomethacin results in increased expression of HSPA5 mRNA CTD PMID:18799549 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
nimesulide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
paracetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression EXP Acetaminophen results in decreased expression of CDKN1A protein CTD PMID:16330492 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G TP53 tumor protein p53 decreases expression EXP Acetaminophen results in decreased expression of TP53 protein CTD PMID:16330492 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP rosmarinic acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:11509739 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 902
    role 861
      application 501
        anti-inflammatory agent 61
          anti-inflammatory drug 51
            non-steroidal anti-inflammatory drug 19
              (-)-beta-caryophyllene 0
              (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
              (E)-3-tosylacrylonitrile 0
              (S)-ketorolac + 0
              4-(methylamino)antipyrine 0
              4-aminoantipyrine 0
              O-methylsalicylic acid + 0
              SC560 0
              [5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid 0
              aceclofenac 0
              acemetacin 0
              acetosyringone + 0
              acetylsalicylic acid + 3
              adapalene 0
              alclofenac 0
              alminoprofen 0
              almotriptan + 0
              almotriptan malate 0
              amfenac + 0
              amfenac sodium hydrate 0
              aminophenazone 0
              amlexanox 0
              amodiaquine + 0
              ampiroxicam 0
              antipyrine + 0
              apazone 0
              apigenin 7-O-beta-D-glucoside 0
              apigenin 7-O-beta-D-glucoside(1-) 0
              apocynin 3
              apremilast 0
              arasertaconazole + 0
              baicalin 0
              balsalazide + 0
              balsalazide disodium 0
              bendazac 0
              benoxaprofen 0
              benzydamine 0
              biphenyl-4-ylacetic acid + 0
              bromfenac 0
              bromfenac sodium salt + 0
              bromfenac sodium salt sesquihydrate 0
              bufexamac 0
              bumadizone 0
              bumadizone calcium + 0
              bumadizone calcium hemihydrate 0
              carprofen + 0
              cimicoxib 0
              clofazimine 0
              clonixin 0
              clonixin lysine salt 0
              corilagin 0
              crisaborole 0
              deracoxib 0
              dexibuprofen 0
              dexketoprofen 0
              diclofenac + 0
              difenpiramide 0
              diflunisal 0
              dithiosalicylic acid 0
              droxicam 0
              eletriptan 0
              eletriptan hydrobromide 0
              enprofylline + 0
              etodolac + 0
              etoricoxib 0
              fenbufen 0
              fendosal 0
              fenoprofen 0
              fenoprofen calcium 0
              firocoxib 0
              flufenamate 0
              flufenamic acid 0
              flunixin 0
              flunixin meglumine 6
              flunoxaprofen 0
              flurbiprofen + 0
              garenoxacin 0
              glafenine 0
              ibufenac 0
              ibuprofen + 1
              ibuproxam 0
              indometacin + 3
              indoprofen 0
              isoxicam 0
              kebuzone 0
              ketoprofen 0
              ketorolac 0
              leflunomide 0
              lonazolac 0
              lonazolac calcium 0
              lornoxicam 0
              loxoprofen + 0
              loxoprofen sodium + 0
              loxoprofen sodium hydrate 0
              lumiracoxib 0
              mavacoxib 0
              meclofenamic acid 0
              mefenamic acid 0
              meloxicam 0
              mesalamine 0
              metamizole 0
              metamizole sodium 0
              metiazinic acid 0
              miroprofen 0
              mofebutazone 0
              nabumetone 0
              naproxcinod 0
              naproxen + 0
              naproxen sodium 0
              naproxol 0
              nedocromil 0
              nepafenac 0
              nimesulide 1
              nitroflurbiprofen 0
              nitrosulindac 0
              oleocanthal 0
              olsalazine 0
              olsalazine sodium 0
              oxametacin 0
              oxaprozin 0
              oxyphenbutazone + 0
              oxyphenbutazone hydrate 0
              paracetamol + 2
              parecoxib 0
              parthenolide + 0
              phenylbutazone + 0
              pirfenidone 0
              piroxicam + 0
              proglumetacin + 0
              proglumetacin dimaleate 0
              propyphenazone 0
              robenacoxib 0
              rofecoxib 0
              rosmarinic acid + 1
              salicin + 0
              salsalate 0
              sertaconazole 0
              sertaconazole nitrate 0
              sodium meclofenamate monohydrate 0
              sulfasalazine 0
              sulindac + 2
              sulindac sulfide 0
              suprofen 0
              suxibuzone 0
              tenidap 0
              tenoxicam 0
              tepoxalin 0
              teriflunomide 0
              tiaprofenic acid 0
              tolfenamic acid 0
              tolmetin 0
              tolmetin sodium + 0
              tolmetin sodium dihydrate 0
              valdecoxib + 0
              vedaprofen 0
              willow bark extract 0
              ximoprofen 0
              zileuton 1
              zomepirac 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 902
    role 861
      application 501
        pharmaceutical 445
          drug 445
            anti-inflammatory drug 51
              non-steroidal anti-inflammatory drug 19
                (-)-beta-caryophyllene 0
                (2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 0
                (E)-3-tosylacrylonitrile 0
                (S)-ketorolac + 0
                4-(methylamino)antipyrine 0
                4-aminoantipyrine 0
                O-methylsalicylic acid + 0
                SC560 0
                [5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid 0
                aceclofenac 0
                acemetacin 0
                acetosyringone + 0
                acetylsalicylic acid + 3
                adapalene 0
                alclofenac 0
                alminoprofen 0
                almotriptan + 0
                almotriptan malate 0
                amfenac + 0
                amfenac sodium hydrate 0
                aminophenazone 0
                amlexanox 0
                amodiaquine + 0
                ampiroxicam 0
                antipyrine + 0
                apazone 0
                apigenin 7-O-beta-D-glucoside 0
                apigenin 7-O-beta-D-glucoside(1-) 0
                apocynin 3
                apremilast 0
                arasertaconazole + 0
                baicalin 0
                balsalazide + 0
                balsalazide disodium 0
                bendazac 0
                benoxaprofen 0
                benzydamine 0
                biphenyl-4-ylacetic acid + 0
                bromfenac 0
                bromfenac sodium salt + 0
                bromfenac sodium salt sesquihydrate 0
                bufexamac 0
                bumadizone 0
                bumadizone calcium + 0
                bumadizone calcium hemihydrate 0
                carprofen + 0
                cimicoxib 0
                clofazimine 0
                clonixin 0
                clonixin lysine salt 0
                corilagin 0
                crisaborole 0
                deracoxib 0
                dexibuprofen 0
                dexketoprofen 0
                diclofenac + 0
                difenpiramide 0
                diflunisal 0
                dithiosalicylic acid 0
                droxicam 0
                eletriptan 0
                eletriptan hydrobromide 0
                enprofylline + 0
                etodolac + 0
                etoricoxib 0
                fenbufen 0
                fendosal 0
                fenoprofen 0
                fenoprofen calcium 0
                firocoxib 0
                flufenamate 0
                flufenamic acid 0
                flunixin 0
                flunixin meglumine 6
                flunoxaprofen 0
                flurbiprofen + 0
                garenoxacin 0
                glafenine 0
                ibufenac 0
                ibuprofen + 1
                ibuproxam 0
                indometacin + 3
                indoprofen 0
                isoxicam 0
                kebuzone 0
                ketoprofen 0
                ketorolac 0
                leflunomide 0
                lonazolac 0
                lonazolac calcium 0
                lornoxicam 0
                loxoprofen + 0
                loxoprofen sodium + 0
                loxoprofen sodium hydrate 0
                lumiracoxib 0
                mavacoxib 0
                meclofenamic acid 0
                mefenamic acid 0
                meloxicam 0
                mesalamine 0
                metamizole 0
                metamizole sodium 0
                metiazinic acid 0
                miroprofen 0
                mofebutazone 0
                nabumetone 0
                naproxcinod 0
                naproxen + 0
                naproxen sodium 0
                naproxol 0
                nedocromil 0
                nepafenac 0
                nimesulide 1
                nitroflurbiprofen 0
                nitrosulindac 0
                oleocanthal 0
                olsalazine 0
                olsalazine sodium 0
                oxametacin 0
                oxaprozin 0
                oxyphenbutazone + 0
                oxyphenbutazone hydrate 0
                paracetamol + 2
                parecoxib 0
                parthenolide + 0
                phenylbutazone + 0
                pirfenidone 0
                piroxicam + 0
                proglumetacin + 0
                proglumetacin dimaleate 0
                propyphenazone 0
                robenacoxib 0
                rofecoxib 0
                rosmarinic acid + 1
                salicin + 0
                salsalate 0
                sertaconazole 0
                sertaconazole nitrate 0
                sodium meclofenamate monohydrate 0
                sulfasalazine 0
                sulindac + 2
                sulindac sulfide 0
                suprofen 0
                suxibuzone 0
                tenidap 0
                tenoxicam 0
                tepoxalin 0
                teriflunomide 0
                tiaprofenic acid 0
                tolfenamic acid 0
                tolmetin 0
                tolmetin sodium + 0
                tolmetin sodium dihydrate 0
                valdecoxib + 0
                vedaprofen 0
                willow bark extract 0
                ximoprofen 0
                zileuton 1
                zomepirac 0
paths to the root