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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antinematodal drug
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Accession:CHEBI:35444 term browser browse the term
Definition:A substance used in the treatment or control of nematode infestations.
Synonyms:related_synonym: antinematodal agent;   antinematodal drugs;   antinematodals


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2-naphthol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects sulfation ISO ABCC1 protein affects the sulfation of 2-naphthol CTD PMID:14742140 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [2-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ar androgen receptor multiple interactions EXP 2-naphthol inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ces1d carboxylesterase 1D affects metabolic processing ISO CES1 protein affects the metabolism of 2-naphthol CTD PMID:12837533 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance ISO CYP1A1 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases abundance
affects binding
decreases activity
ISO CYP1A2 protein results in increased abundance of 2-naphthol
2-naphthol binds to CYP1A2 protein
2-naphthol results in decreased activity of CYP1A2 protein
CTD PMID:15916432, PMID:16243959, PMID:32278787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [2-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases abundance ISO CYP2B6 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases abundance ISO CYP2E1 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO SULT4A1 protein results in increased metabolism of 2-naphthol CTD PMID:12039030 NCBI chr 7:124,958,546...124,982,602
Ensembl chr 7:124,958,546...124,982,566
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 2-naphthol binds to and results in decreased activity of THRB protein CTD PMID:18584933 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of 2-naphthol CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
ascaridole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc6 ERCC excision repair 6, chromatin remodeling factor affects response to substance ISO ERCC6 protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr16:8,734,028...8,804,610
Ensembl chr16:8,734,035...8,804,610
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor affects response to substance ISO XPC protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
carbendazim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 increases expression EXP carbendazim results in increased expression of ABI2 mRNA CTD PMID:22952946 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO carbendazim results in increased expression of ACACA mRNA CTD PMID:26071454 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of AGPAT2 mRNA CTD PMID:26071454 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]
carbendazim affects the localization of AHR protein
CTD PMID:27286660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bag1 BAG cochaperone 1 increases expression EXP carbendazim results in increased expression of BAG1 mRNA CTD PMID:22952946 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bcl2l14 BCL2 like 14 increases expression EXP carbendazim results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 4:168,139,964...168,183,726
Ensembl chr 4:168,142,271...168,183,096
JBrowse link
G Casp3 caspase 3 increases activity ISO carbendazim results in increased activity of CASP3 protein CTD PMID:30851412 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623
JBrowse link
G Cldn11 claudin 11 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein CTD PMID:28576679 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Clu clusterin decreases expression
increases expression
EXP carbendazim results in decreased expression of CLU mRNA
carbendazim results in increased expression of CLU mRNA
CTD PMID:22952946, PMID:27466211 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression
ISO carbendazim results in increased activity of CYP19A1 protein
carbendazim results in increased expression of CYP19A1 mRNA
CTD PMID:14691014 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO
EXP
carbendazim results in increased expression of CYP1A1 mRNA; carbendazim results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]; salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]
CTD PMID:10103034, PMID:21784029, PMID:27286660 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO carbendazim results in increased expression of CYP1A2 mRNA; carbendazim results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO carbendazim results in increased expression of CYP2B6 mRNA CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression ISO carbendazim results in increased expression of DGAT1 mRNA CTD PMID:26071454 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of DGAT2 mRNA CTD PMID:26071454 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 3:2,569,135...2,573,387
Ensembl chr 3:2,569,135...2,573,387
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP carbendazim results in decreased expression of ESR1 mRNA CTD PMID:28576679 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 decreases expression EXP carbendazim results in decreased expression of ESR2 mRNA CTD PMID:28576679 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 increases expression EXP carbendazim results in increased expression of FANK1 mRNA CTD PMID:22952946 NCBI chr 1:205,842,469...205,954,152
Ensembl chr 1:205,842,489...205,950,371
JBrowse link
G Foxa2 forkhead box A2 increases expression ISO carbendazim results in increased expression of FOXA2 mRNA CTD PMID:26071454 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Ift81 intraflagellar transport 81 decreases expression EXP carbendazim results in decreased expression of IFT81 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr12:39,420,161...39,507,412
Ensembl chr12:39,423,596...39,506,890
JBrowse link
G Il1b interleukin 1 beta increases expression ISO carbendazim results in increased expression of IL1B mRNA; carbendazim results in increased expression of IL1B protein CTD PMID:26071454 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO carbendazim results in increased expression of IL6 mRNA; carbendazim results in increased expression of IL6 protein CTD PMID:26071454 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression ISO carbendazim results in decreased expression of ITGA5 mRNA CTD PMID:25530041 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO carbendazim results in decreased expression of ITGB1 mRNA CTD PMID:25530041 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Loxl1 lysyl oxidase-like 1 multiple interactions
increases expression
EXP 2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA CTD PMID:22382377 NCBI chr 8:63,067,757...63,092,124
Ensembl chr 8:63,067,300...63,092,009
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO carbendazim results in decreased expression of LPL protein CTD PMID:30496565 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrrc6 leucine rich repeat containing 6 decreases expression EXP carbendazim results in decreased expression of LRRC6 mRNA CTD PMID:27466211 NCBI chr 7:107,130,402...107,231,507
Ensembl chr 7:107,130,402...107,223,047
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA CTD PMID:22382377 NCBI chr 1:222,310,916...222,451,485
Ensembl chr 1:222,310,920...222,451,484
JBrowse link
G Mfap3l microfibril associated protein 3 like increases expression EXP carbendazim results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr16:32,734,059...32,777,091
Ensembl chr16:32,738,265...32,753,278
JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP carbendazim results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr13:44,916,534...44,916,615
Ensembl chr13:44,916,534...44,916,615
JBrowse link
G Mir423 microRNA 423 increases expression EXP carbendazim results in increased expression of MIR423 mRNA CTD PMID:32418910 NCBI chr10:63,098,366...63,098,444
Ensembl chr10:63,098,360...63,098,453
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO carbendazim results in decreased expression of MMP2 mRNA CTD PMID:25530041 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO carbendazim results in decreased expression of MMP9 mRNA CTD PMID:25530041 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO carbendazim results in increased expression of NFE2L2 protein CTD PMID:30851412 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression EXP carbendazim results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO carbendazim results in decreased expression of PLAU mRNA CTD PMID:25530041 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression EXP carbendazim results in decreased expression of PTGDS mRNA CTD PMID:22952946 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO carbendazim results in increased expression of SERPINE2 mRNA CTD PMID:25530041 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Sil1 SIL1 nucleotide exchange factor decreases expression EXP carbendazim results in decreased expression of SIL1 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr18:28,067,476...28,302,008
Ensembl chr18:28,067,484...28,301,863
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP carbendazim results in increased expression of SOD3 mRNA CTD PMID:27466211 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO carbendazim results in increased expression of SREBF1 mRNA CTD PMID:26071454 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 decreases expression EXP carbendazim results in decreased expression of TBC1D5 mRNA CTD PMID:27466211 NCBI chr 9:1,144,641...1,747,732
Ensembl chr 9:1,145,700...1,746,397
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO carbendazim results in increased expression of TIMP1 mRNA CTD PMID:25530041 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO carbendazim results in increased expression of TIMP2 mRNA CTD PMID:25530041 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnp1 transition protein 1 increases expression EXP carbendazim results in increased expression of TNP1 mRNA CTD PMID:28576679 NCBI chr 9:80,294,837...80,295,446
Ensembl chr 9:80,294,840...80,295,446
JBrowse link
G Tnp2 transition protein 2 increases expression EXP carbendazim results in increased expression of TNP2 mRNA CTD PMID:28576679 NCBI chr10:4,953,898...4,954,626
Ensembl chr10:4,953,879...4,954,624
JBrowse link
closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions
ISO ABCB1A protein results in decreased susceptibility to closantel
closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
CTD PMID:20513441 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Slc25a31 solute carrier family 25 member 31 decreases activity ISO closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 2:127,538,323...127,554,276
Ensembl chr 2:127,538,659...127,554,307
JBrowse link
G Slc25a4 solute carrier family 25 member 4 decreases activity ISO closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc25a5 solute carrier family 25 member 5 decreases activity ISO closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc25a6 solute carrier family 25 member 6 decreases activity ISO closantel results in decreased activity of SLC25A6 protein CTD PMID:26746582 NCBI chr18:70,959,872...70,961,040
Ensembl chr18:70,959,887...70,960,786
JBrowse link
G Thra thyroid hormone receptor alpha increases activity EXP closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta increases activity EXP closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
eprinomectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO eprinomectin results in decreased activity of ABCB1A protein CTD PMID:17134887 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
ethoprophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO ethoprop metabolite results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethoprophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
fenbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B increases expression EXP Fenbendazole results in increased expression of AURKB protein CTD PMID:23411599 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Cbx5 chromobox 5 increases expression EXP Fenbendazole results in increased expression of CBX5 protein CTD PMID:23411599 NCBI chr 7:144,819,673...144,865,014
Ensembl chr 7:144,819,420...144,837,583
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Fenbendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP Fenbendazole results in increased expression of CCND1 mRNA CTD PMID:23411599 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne2 cyclin E2 increases expression EXP Fenbendazole results in increased expression of CCNE2 mRNA CTD PMID:23411599 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Fenbendazole results in increased expression of CDK1 mRNA; Fenbendazole results in increased expression of CDK1 protein CTD PMID:23411599 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Fenbendazole results in increased expression of CDKN1A mRNA; Fenbendazole results in increased expression of CDKN1A protein CTD PMID:23411599 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases methylation
increases expression
decreases expression
EXP Fenbendazole results in increased methylation of CDKN2A gene
Fenbendazole results in increased expression of CDKN2A protein
Fenbendazole results in decreased expression of CDKN2A protein
CTD PMID:22659510, PMID:23411599 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression EXP Fenbendazole results in increased expression of CDKN2B mRNA CTD PMID:23411599 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdr2 cerebellar degeneration-related protein 2 increases expression EXP Fenbendazole results in increased expression of CDR2 mRNA CTD PMID:23411599 NCBI chr 1:190,889,698...190,914,606
Ensembl chr 1:190,889,701...190,914,610
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Fenbendazole results in decreased activity of CYP1A2 protein CTD PMID:22048645 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Fenbendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Fenbendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Incenp inner centromere protein increases expression EXP Fenbendazole results in increased expression of INCENP protein CTD PMID:23411599 NCBI chr 1:225,923,448...225,953,384
Ensembl chr 1:225,925,773...225,952,516
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Fenbendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Fenbendazole results in increased expression of MKI67 protein CTD PMID:23411599 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Fenbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Tmem70 transmembrane protein 70 multiple interactions EXP [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of TMEM70 protein CTD PMID:27914986 NCBI chr 5:2,019,852...2,037,038
Ensembl chr 5:2,019,852...2,037,038
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
ISO Fenbendazole results in increased secretion of TNF protein
U 0126 inhibits the reaction [Fenbendazole results in increased secretion of TNF protein]
CTD PMID:20848085 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Fenbendazole results in increased expression of TP53 protein CTD PMID:23411599 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 multiple interactions EXP [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of UBE2E2 protein CTD PMID:27914986 NCBI chr15:7,402,210...7,928,320
Ensembl chr15:7,871,497...7,927,939
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Fenbendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase decreases expression EXP Fenbendazole results in decreased expression of WEE1 protein modified form CTD PMID:23411599 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
JBrowse link
flubendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 decreases expression ISO flubendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases phosphorylation ISO flubendazole results in increased phosphorylation of BCL2 protein CTD PMID:32652169 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases phosphorylation ISO flubendazole results in increased phosphorylation of BCL2L1 protein CTD PMID:32652169 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
ISO flubendazole results in increased cleavage of CASP3 protein
BAY 11-7085 affects the reaction [flubendazole results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]
CTD PMID:32652169 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO flubendazole results in increased activity of MAPK8 protein CTD PMID:32652169 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases phosphorylation ISO flubendazole results in increased phosphorylation of MCL1 protein CTD PMID:32652169 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO flubendazole results in increased expression of PMAIP1 protein CTD PMID:32652169 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO flubendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO flubendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
ISO flubendazole results in increased activity of RELA protein
4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine affects the reaction [flubendazole results in increased activity of RELA protein]; BAY 11-7085 affects the reaction [flubendazole results in increased activity of RELA protein]
CTD PMID:32652169 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO flubendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tp53 tumor protein p53 increases activity ISO flubendazole results in increased activity of TP53 protein CTD PMID:32652169 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
increases expression
decreases activity
increases export
decreases response to substance
multiple interactions
increases response to substance
affects binding
affects response to substance
ISO ABCB1 gene polymorphism affects the abundance of Ivermectin
Ivermectin results in increased expression of ABCB1A mRNA
Ivermectin results in decreased activity of ABCB1A protein
ABCB1A protein results in increased export of Ivermectin
ABCB1A protein results in decreased susceptibility to Ivermectin
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin results in increased expression of and results in increased stability of ABCB1A mRNA; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
ABCB1A gene mutant form results in increased susceptibility to Ivermectin; ABCB1A protein mutant form results in increased susceptibility to Ivermectin
Ivermectin results in decreased activity of ABCB1 protein
ABCB1 protein affects the abundance of Ivermectin
Ivermectin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
Ivermectin binds to ABCB1 protein
ABCB1 gene polymorphism affects the susceptibility to Ivermectin
CTD PMID:8917702, PMID:8949985, PMID:9144452, PMID:17134887, PMID:18633165, PMID:19161460, PMID:20513441, PMID:20595473, PMID:20630055, PMID:22024132, PMID:22834856, PMID:24998875, PMID:25865432 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
increases expression
ISO [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin results in increased expression of and results in increased stability of ABCB1B mRNA
Ivermectin results in increased expression of ABCB1B mRNA
CTD PMID:19161460, PMID:22024132, PMID:24998875 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases activity
ISO Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
Ivermectin results in decreased activity of ABCC1 protein
CTD PMID:25865432 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Ivermectin results in increased expression of ABCC2 mRNA CTD PMID:24998875 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Ivermectin results in increased expression of ABCG2 mRNA CTD PMID:24998875 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acaca acetyl-CoA carboxylase alpha affects expression
decreases expression
multiple interactions
ISO Ivermectin affects the expression of ACACA mRNA
Ivermectin results in decreased expression of ACACA mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein]
Ivermectin inhibits the reaction [Palmitic Acid results in decreased phosphorylation of ACACA protein]
CTD PMID:30738135, PMID:31199990 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA CTD PMID:16861626 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Adm adrenomedullin decreases expression ISO Ivermectin results in decreased expression of ADM mRNA CTD PMID:28942281 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression ISO Ivermectin results in increased expression of ALDH1L2 mRNA CTD PMID:28942281 NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression ISO Ivermectin results in increased expression of ANGPTL6 mRNA CTD PMID:28942281 NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829
JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA CTD PMID:16861626 NCBI chr 9:95,783,651...95,787,092
Ensembl chr 9:95,786,508...95,787,094
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Ivermectin results in increased expression of ATF4 mRNA CTD PMID:28942281 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf5 activating transcription factor 5 increases expression ISO Ivermectin results in increased expression of ATF5 mRNA CTD PMID:28942281 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Ivermectin results in increased expression of ATF6 mRNA CTD PMID:28942281 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bag3 BAG cochaperone 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA CTD PMID:16861626 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Ivermectin results in increased expression of BAX protein CTD PMID:28811376 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid results in increased expression of BBC3 mRNA] CTD PMID:24658405 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO Ivermectin results in decreased expression of BNIP3 mRNA CTD PMID:28942281 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression ISO Ivermectin results in decreased expression of CAMP mRNA; Ivermectin results in decreased expression of CAMP protein CTD PMID:28653460 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Ivermectin results in decreased activity of CAT protein
Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein]
CTD PMID:28880400 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein CTD PMID:16861626 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA CTD PMID:16861626 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA CTD PMID:16861626 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610
JBrowse link
G Cd36 CD36 molecule affects expression ISO Ivermectin affects the expression of CD36 mRNA CTD PMID:31199990 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cdh1 cadherin 1 increases expression ISO Ivermectin results in increased expression of CDH1 CTD PMID:26078298 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Ivermectin results in increased expression of CDKN1A protein CTD PMID:28811376 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Ivermectin results in increased expression of CDKN1B protein CTD PMID:28811376 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression
multiple interactions
ISO Ivermectin affects the expression of CEBPA mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of CEBPA mRNA]
CTD PMID:31199990 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 increases expression ISO Ivermectin results in increased expression of COX6A2 mRNA; Ivermectin results in increased expression of COX6A2 protein CTD PMID:28942281 NCBI chr 1:199,624,037...199,626,255
Ensembl chr 1:199,624,037...199,624,783
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression
multiple interactions
ISO Ivermectin affects the expression of CPT1A mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
CTD PMID:30738135, PMID:31199990 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crp C-reactive protein increases expression ISO Ivermectin results in increased expression of CRP protein CTD PMID:8555762 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA CTD PMID:16861626 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
ISO Ivermectin results in decreased activity of CYP1A1 protein
Ivermectin results in increased expression of CYP1A1 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Ivermectin results in increased expression of CYP1A2 mRNA CTD PMID:24998875 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ivermectin results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity
increases expression
ISO Ivermectin results in decreased activity of CYP2B10 protein
Ivermectin results in increased expression of CYP2B10 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Ivermectin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Ivermectin results in decreased activity of CYP2D6 protein
Ivermectin results in decreased activity of CYP2D22 protein
CTD PMID:11124226, PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Ivermectin results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
affects expression
multiple interactions
ISO Ivermectin results in increased expression of DDIT3 mRNA
Ivermectin affects the expression of DDIT3 mRNA
Ivermectin promotes the reaction [Palmitic Acid results in increased expression of DDIT3 protein]
CTD PMID:28942281, PMID:30738135, PMID:31199990 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA CTD PMID:16861626 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA CTD PMID:16861626 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Ivermectin results in increased expression of EDEM1 mRNA CTD PMID:28942281 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression ISO Ivermectin results in decreased expression of EGLN3 mRNA CTD PMID:28942281 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Ivermectin results in increased expression of ESR1 CTD PMID:26078298 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fabp4 fatty acid binding protein 4 affects expression
multiple interactions
ISO Ivermectin affects the expression of FABP4 mRNA
Rosiglitazone affects the reaction [Ivermectin affects the expression of FABP4 mRNA]
CTD PMID:31199990 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fasn fatty acid synthase affects expression ISO Ivermectin affects the expression of FASN mRNA CTD PMID:31199990 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Ivermectin results in increased expression of GDF15 mRNA CTD PMID:28942281 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA CTD PMID:16861626 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Glra1 glycine receptor, alpha 1 increases activity
multiple interactions
affects activity
ISO Ivermectin results in increased activity of GLRA1 protein mutant form
Ivermectin affects the reaction [Glycine affects the activity of GLRA1 protein mutant form]
Ivermectin affects the activity of GLRA1 protein mutant form
CTD PMID:25231486, PMID:27958714 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Glra3 glycine receptor, alpha 3 affects expression ISO Ivermectin affects the expression of GLRA3 mRNA CTD PMID:31199990 NCBI chr16:37,676,959...37,908,221
Ensembl chr16:37,676,962...38,063,821
JBrowse link
G Glrb glycine receptor, beta affects expression ISO Ivermectin affects the expression of GLRB mRNA CTD PMID:31199990 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547
JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA CTD PMID:16861626 NCBI chr15:108,364,701...108,376,221
Ensembl chr15:108,364,701...108,376,221
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA CTD PMID:16861626 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA CTD PMID:16861626 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression
multiple interactions
EXP Ivermectin results in increased expression of HSPA1A mRNA
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA]
CTD PMID:28880400 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA CTD PMID:16861626 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Ivermectin results in increased expression of HSPA5 protein CTD PMID:30738135 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA CTD PMID:16861626 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO Ivermectin results in increased expression of HSPA9 mRNA CTD PMID:28942281 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions
increases expression
ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA
Ivermectin results in increased expression of HSPD1 mRNA
CTD PMID:16861626, PMID:28942281 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA CTD PMID:16861626 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA CTD PMID:16861626 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression
multiple interactions
EXP Ivermectin results in increased expression of IGFBP3 mRNA
Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA]
CTD PMID:28880400 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein CTD PMID:16861626 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA CTD PMID:16861626 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO Ivermectin results in increased expression of LONP1 mRNA CTD PMID:28942281 NCBI chr 9:10,428,853...10,441,180
Ensembl chr 9:10,428,853...10,441,177
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA CTD PMID:16861626 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:19168156 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:19168156 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:19168156 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mxd1 max dimerization protein 1 multiple interactions ISO Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 4:118,451,752...118,472,150
Ensembl chr 4:118,449,882...118,472,179
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Ivermectin results in decreased expression of NANOG mRNA; Ivermectin results in decreased expression of NANOG protein CTD PMID:29257278 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases expression ISO Ivermectin results in decreased expression of NDRG1 mRNA CTD PMID:28942281 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:19168156 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO Ivermectin results in decreased expression of NQO1 mRNA; Ivermectin results in decreased expression of NQO1 protein CTD PMID:22021338 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
affects expression
ISO Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
Ivermectin results in increased expression of NR1H4 mRNA
Ivermectin affects the expression of NR1H4 mRNA
CTD PMID:27773686, PMID:30738135, PMID:31199990 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ivermectin results in increased expression of NUPR1 mRNA CTD PMID:28942281 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G P2rx4 purinergic receptor P2X 4 multiple interactions
increases activity
ISO Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
Ivermectin results in increased activity of P2RX4 protein
CTD PMID:19560503, PMID:21638035, PMID:30545933 NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO Ivermectin results in increased expression of PARP1 protein modified form CTD PMID:28811376 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pfkl phosphofructokinase, liver type decreases expression ISO Ivermectin results in decreased expression of PFKL mRNA CTD PMID:28942281 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Ivermectin results in decreased expression of POU5F1 mRNA; Ivermectin results in decreased expression of POU5F1 protein CTD PMID:29257278 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO Ivermectin results in decreased expression of PPARA mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of PPARA mRNA]
CTD PMID:30738135 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
multiple interactions
ISO Ivermectin affects the expression of PPARG mRNA
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of PPARG mRNA]
CTD PMID:31199990 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA CTD PMID:16861626 NCBI chr 2:178,354,830...178,366,843
Ensembl chr 2:178,354,890...178,366,685
JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA CTD PMID:16861626 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ptges3 prostaglandin E synthase 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:19168156 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 increases expression ISO Ivermectin results in increased expression of RPP14 mRNA CTD PMID:28942281 NCBI chr15:18,625,963...18,636,157
Ensembl chr15:18,625,964...18,632,536
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Ivermectin results in decreased expression of SERPINE1 mRNA CTD PMID:28942281 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions ISO Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 8:61,748,590...61,803,314
Ensembl chr 8:61,762,768...61,803,099
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA CTD PMID:16861626 NCBI chr 4:81,816,778...81,968,832
Ensembl chr 4:81,818,569...81,968,832
JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO Ivermectin results in decreased expression of SLC2A1 mRNA CTD PMID:28942281 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects expression ISO Ivermectin affects the expression of SLC2A4 mRNA CTD PMID:31199990 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Ivermectin results in decreased expression of SOX2 mRNA; Ivermectin results in decreased expression of SOX2 protein CTD PMID:29257278 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G St13 ST13, Hsp70 interacting protein multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA CTD PMID:16861626 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Tcp1 t-complex 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA CTD PMID:16861626 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tfrc transferrin receptor decreases expression ISO Ivermectin results in decreased expression of TFRC mRNA CTD PMID:28942281 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA CTD PMID:16861626 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Ivermectin results in decreased expression of TLR2 protein CTD PMID:28653460 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO Ivermectin results in decreased expression of TLR4 mRNA CTD PMID:28653460 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Ivermectin results in decreased expression of TNF mRNA CTD PMID:28653460 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid affects the localization of TP53 protein mutant form] CTD PMID:24658405 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Ivermectin results in increased expression of TRIB3 mRNA CTD PMID:28942281 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA CTD PMID:16861626 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
kainic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Kainic Acid results in increased expression of ABCB1A mRNA; Kainic Acid results in increased expression of ABCB1A protein CTD PMID:14706787 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Kainic Acid results in increased expression of ABCB1B mRNA; Kainic Acid results in increased expression of ABCB1B protein CTD PMID:14706787 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Kainic Acid results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Aco2 aconitase 2 multiple interactions
decreases activity
EXP 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein] CTD PMID:11520895 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Acp1 acid phosphatase 1 decreases expression ISO Kainic Acid results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr 6:49,836,064...49,851,714
Ensembl chr 6:49,836,075...49,851,714
JBrowse link
G Adk adenosine kinase increases expression ISO Kainic Acid results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Adnp activity-dependent neuroprotector homeobox multiple interactions
decreases expression
EXP Enzyme Inhibitors inhibits the reaction [Kainic Acid results in decreased expression of ADNP protein]
Kainic Acid results in decreased expression of ADNP mRNA; Kainic Acid results in decreased expression of ADNP protein
CTD PMID:18375135 NCBI chr 3:164,937,188...164,964,819
Ensembl chr 3:164,937,198...164,964,702
JBrowse link
G Adra1b adrenoceptor alpha 1B increases response to substance ISO ADRA1B protein results in increased susceptibility to Kainic Acid CTD PMID:19125850 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
EXP Kainic Acid results in increased expression of AIF1 protein
NADP inhibits the reaction [Kainic Acid results in increased expression of AIF1 protein]
CTD PMID:32057834 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases localization
multiple interactions
ISO Kainic Acid results in increased localization of AIFM1 protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]
CTD PMID:16469440 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Kainic Acid results in increased expression of ALOX5AP mRNA CTD PMID:19700661 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Kainic Acid results in increased expression of APAF1 mRNA CTD PMID:17997037 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions EXP [Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA CTD PMID:16120186 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoe apolipoprotein E decreases expression ISO Kainic Acid results in decreased expression of APOE mRNA CTD PMID:17997037 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP
ISO
Kainic Acid results in increased expression of ARC mRNA; Kainic Acid results in increased expression of ARC protein CTD PMID:17632064, PMID:30557575 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Atf7ip activating transcription factor 7 interacting protein decreases expression EXP Kainic Acid results in decreased expression of ATF7IP mRNA CTD PMID:19700661 NCBI chr 4:170,476,998...170,563,063
Ensembl chr 4:170,518,673...170,559,532
JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression
EXP NADP inhibits the reaction [Kainic Acid results in increased expression of ATG5 protein] CTD PMID:32057834 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G B4galt2 beta-1,4-galactosyltransferase 2 decreases expression ISO Kainic Acid results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 5:136,707,510...136,717,345
Ensembl chr 5:136,707,510...136,715,981
JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Kainic Acid results in increased expression of BAG3 mRNA CTD PMID:19700661 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP
ISO
Kainic Acid results in increased expression of BAX mRNA; Kainic Acid results in increased expression of BAX protein
oridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]
Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of BAX protein]
CTD PMID:18711747, PMID:19700661, PMID:25453207, PMID:31430510 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]
Kainic Acid results in decreased expression of BCL2 mRNA
oridonin inhibits the reaction [Kainic Acid results in decreased expression of BCL2 mRNA]
CTD PMID:25453207, PMID:31430510 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
increases expression
EXP [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]
Kainic Acid results in increased expression of BDNF mRNA; Kainic Acid results in increased expression of BDNF protein
CTD PMID:1641125, PMID:9073163, PMID:11279263, PMID:16166269, PMID:17827730, PMID:19700661 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
EXP NADP inhibits the reaction [Kainic Acid results in increased expression of BECN1 protein] CTD PMID:32057834 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G C1qb complement C1q B chain increases expression ISO Kainic Acid results in increased expression of C1QB mRNA CTD PMID:17997037 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G C4b complement C4B (Chido blood group) increases expression ISO Kainic Acid results in increased expression of C4B mRNA CTD PMID:17997037 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Calb1 calbindin 1 decreases expression ISO Kainic Acid results in decreased expression of CALB1 mRNA CTD PMID:17997037 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO Kainic Acid results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
JBrowse link
G Capns1 calpain, small subunit 1 increases expression EXP Kainic Acid results in increased expression of CAPNS1 mRNA CTD PMID:19700661 NCBI chr 1:91,058,528...91,064,880 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression
ISO
EXP
Kainic Acid results in increased activity of CASP3 protein
oridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]
Kainic Acid results in increased cleavage of CASP3 protein
Kainic Acid results in increased expression of CASP3 mRNA; Kainic Acid results in increased expression of CASP3 protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]]; Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]
CTD PMID:16469440, PMID:18711747, PMID:19700661, PMID:25453207, PMID:31430510 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions
ISO
EXP
Kainic Acid results in decreased expression of CAT mRNA; Kainic Acid results in decreased expression of CAT protein
Kainic Acid results in decreased activity of CAT protein
oridonin inhibits the reaction [Kainic Acid results in decreased activity of CAT protein]
CTD PMID:29208536, PMID:31430510 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cck cholecystokinin decreases expression EXP Kainic Acid results in decreased expression of CCK protein CTD PMID:7774662 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Kainic Acid results in increased expression of CCL2 mRNA CTD PMID:19700661 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccne1 cyclin E1 increases expression EXP Kainic Acid results in increased expression of CCNE1 protein CTD PMID:12941380 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd68 Cd68 molecule increases expression EXP Kainic Acid results in increased expression of CD68 mRNA CTD PMID:19700661 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdc42 cell division cycle 42 increases expression EXP Kainic Acid results in increased expression of CDC42 mRNA CTD PMID:19700661 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdh13 cadherin 13 increases expression ISO Kainic Acid results in increased expression of CDH13 mRNA CTD PMID:17997037 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression EXP Kainic Acid results in increased expression of CDK2 protein CTD PMID:12941380 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 increases expression ISO Kainic Acid results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Chgb chromogranin B increases expression EXP Kainic Acid results in increased expression of CHGB mRNA CTD PMID:9427505 NCBI chr 3:125,428,050...125,441,601
Ensembl chr 3:125,428,260...125,441,594
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression EXP Kainic Acid results in increased expression of CITED2 mRNA CTD PMID:19700661 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression EXP Kainic Acid results in increased expression of CNR1 mRNA CTD PMID:22079489 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 increases expression EXP Kainic Acid results in increased expression of CNRIP1 mRNA CTD PMID:22079489 NCBI chr14:100,217,547...100,247,235
Ensembl chr14:100,217,289...100,247,235
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Kainic Acid results in increased expression of COL1A1 mRNA CTD PMID:17997037 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP Kainic Acid results in increased expression of CRHR1 mRNA CTD PMID:12093084 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Ctsb cathepsin B multiple interactions
increases expression
EXP NADP inhibits the reaction [Kainic Acid results in increased expression of CTSB protein] CTD PMID:32057834 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
EXP NADP inhibits the reaction [Kainic Acid results in increased expression of CTSD protein] CTD PMID:32057834 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Ctss cathepsin S increases expression ISO Kainic Acid results in increased expression of CTSS mRNA; Kainic Acid results in increased expression of CTSS protein CTD PMID:17997037 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Ctsz cathepsin Z increases expression ISO Kainic Acid results in increased expression of CTSZ mRNA CTD PMID:17997037 NCBI chr 3:172,527,107...172,537,877
Ensembl chr 3:172,527,107...172,537,877
JBrowse link
G Cycs cytochrome c, somatic increases localization
multiple interactions
increases expression
ISO
EXP
Kainic Acid results in increased localization of CYCS protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
Kainic Acid results in increased expression of CYCS mRNA
CTD PMID:16469440, PMID:19700661 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dgcr6 DiGeorge syndrome critical region gene 6 decreases expression ISO Kainic Acid results in decreased expression of DGCR6 mRNA CTD PMID:17997037 NCBI chr11:87,076,205...87,081,306
Ensembl chr11:87,076,381...87,081,950
JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression ISO Kainic Acid results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 2:152,785,844...152,824,549
Ensembl chr 2:152,785,844...152,824,547
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression EXP Kainic Acid results in increased expression of DIABLO mRNA CTD PMID:19700661 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Drd2 dopamine receptor D2 decreases response to substance ISO DRD2 protein results in decreased susceptibility to Kainic Acid CTD PMID:11860278 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egr1 early growth response 1 decreases expression
affects expression
ISO
EXP
Kainic Acid results in decreased expression of EGR1 mRNA
Kainic Acid affects the expression of EGR1 mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 increases expression EXP Kainic Acid results in increased expression of EIF4A3 protein CTD PMID:17632064 NCBI chr10:108,415,201...108,425,195
Ensembl chr10:108,415,202...108,425,206
JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression ISO Kainic Acid results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G En2 engrailed homeobox 2 affects response to substance
decreases expression
ISO EN2 protein affects the susceptibility to Kainic Acid
Kainic Acid results in decreased expression of EN2 mRNA
CTD PMID:19186208 NCBI chr 4:438,668...444,508
Ensembl chr 4:438,668...444,501
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Kainic Acid results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor multiple interactions
decreases expression
ISO
EXP
EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO Kainic Acid results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976
JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 decreases expression ISO Kainic Acid results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 3:2,726,705...2,731,213
Ensembl chr 3:2,727,254...2,731,212
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Kainic Acid results in increased expression of FGF2 mRNA CTD PMID:7649223 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression EXP Kainic Acid results in increased expression of FGF5 mRNA CTD PMID:7649223 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Kainic Acid results in increased expression of FGFR1 mRNA CTD PMID:7649223 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
ISO
EXP
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone inhibits the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in increased expression of FOS mRNA; Kainic Acid results in increased expression of FOS protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in decreased expression of FOS mRNA
CTD PMID:7655348, PMID:7887109, PMID:8417141, PMID:8758711, PMID:15723099, PMID:16686654, PMID:17827730, PMID:17997037, PMID:26348896 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit increases expression EXP Kainic Acid results in increased expression of FOSL2 mRNA CTD PMID:19700661 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 decreases expression ISO Kainic Acid results in decreased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 1:89,484,197...89,488,279
Ensembl chr 1:89,484,199...89,488,223
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 increases expression
multiple interactions
ISO Kainic Acid results in increased expression of GABRB1 mRNA
Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB1 mRNA]
CTD PMID:27386150 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB3 mRNA] CTD PMID:27386150 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Kainic Acid results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression EXP Kainic Acid results in increased expression of GAD2 mRNA CTD PMID:16797850 NCBI chr17:89,171,576...89,234,770
Ensembl chr17:89,171,250...89,238,040
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Kainic Acid results in increased expression of GADD45A mRNA; Kainic Acid results in increased expression of GADD45A protein CTD PMID:20955365 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression ISO Kainic Acid results in decreased expression of GADD45B mRNA CTD PMID:17997037 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma decreases expression ISO Kainic Acid results in decreased expression of GADD45G mRNA CTD PMID:17997037 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gap43 growth associated protein 43 multiple interactions
increases expression
EXP Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression ISO Kainic Acid results in increased expression of GCNT2 mRNA CTD PMID:17997037 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions
EXP
ISO
Kainic Acid results in increased expression of GFAP mRNA; Kainic Acid results in increased expression of GFAP protein
NADP inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]
CTD PMID:17997037, PMID:18711747, PMID:19700661, PMID:21589914, PMID:22790971, PMID:32057834 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions
decreases expression
EXP oridonin inhibits the reaction [Kainic Acid results in decreased expression of GLUL mRNA] CTD PMID:31430510 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression ISO Kainic Acid results in decreased expression of GPX1 protein CTD PMID:29208536 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
decreases expression
EXP
ISO
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of GRIA1 protein]; Kainic Acid binds to and results in increased activity of GRIA1 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA1 protein]
Kainic Acid results in decreased expression of GRIA1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]
Kainic Acid results in decreased expression of GRIA1 mRNA; Kainic Acid results in decreased expression of GRIA1 protein
CTD PMID:7529610, PMID:11812690, PMID:17585341, PMID:21589914 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions
increases methylation
decreases expression
affects response to substance
EXP
ISO
Kainic Acid binds to and results in increased activity of GRIA2 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein]
Kainic Acid results in increased methylation of GRIA2 gene
Kainic Acid results in decreased expression of GRIA2 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA]; RG108 inhibits the reaction [Kainic Acid results in increased methylation of GRIA2 gene]
GRIA2 protein affects the susceptibility to Kainic Acid
CTD PMID:7529610, PMID:10551584, PMID:11812690, PMID:21589914, PMID:24098468 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression
multiple interactions
increases expression
EXP
ISO
Kainic Acid results in decreased expression of GRIA3 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]
Kainic Acid results in increased expression of GRIA3 mRNA
CTD PMID:7529610, PMID:21589914 NCBI chr  X:127,561,843...127,829,763
Ensembl chr  X:127,562,660...127,829,753
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIA4 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA]
CTD PMID:21589914 NCBI chr 8:1,548,145...2,045,874
Ensembl chr 8:1,548,146...2,045,817
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 decreases expression
increases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIK1 mRNA
Kainic Acid results in increased expression of GRIK1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]
CTD PMID:21589914, PMID:29208536 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 increases expression
multiple interactions
ISO Kainic Acid results in increased expression of GRIK2 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA
CTD PMID:17997037, PMID:21589914, PMID:29208536 NCBI chr20:53,791,428...54,517,691
Ensembl chr20:53,789,760...54,517,709
JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIK3 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA
CTD PMID:21589914 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
JBrowse link
G Grik4 glutamate ionotropic receptor kainate type subunit 4 multiple interactions
decreases expression
ISO [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA
Kainic Acid results in decreased expression of GRIK4 mRNA
CTD PMID:21589914 NCBI chr 8:46,804,134...47,237,546
Ensembl chr 8:46,806,147...47,094,352
JBrowse link
G Grik5 glutamate ionotropic receptor kainate type subunit 5 multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr 1:81,885,516...81,946,731
Ensembl chr 1:81,885,521...81,946,714
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects expression
decreases expression
ISO
EXP
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA]
Kainic Acid affects the expression of GRIN1
CTD PMID:21589914, PMID:23159308 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN2A mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA]
CTD PMID:21589914 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression
ISO celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN2C mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]
CTD PMID:21589914 NCBI chr10:103,798,290...103,816,923
Ensembl chr10:103,798,291...103,816,287
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN2D mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]
CTD PMID:21589914 NCBI chr 1:101,819,068...101,859,146
Ensembl chr 1:101,820,461...101,856,881
JBrowse link
G Grin3a glutamate ionotropic receptor NMDA type subunit 3A multiple interactions
decreases expression
ISO Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 5:64,928,620...65,073,012
Ensembl chr 5:64,928,620...65,073,012
JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GRIN3B mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA]
CTD PMID:21589914 NCBI chr 7:12,764,993...12,771,310
Ensembl chr 7:12,764,993...12,771,310
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
decreases phosphorylation
multiple interactions
ISO Kainic Acid results in decreased activity of GSK3B protein
Kainic Acid results in decreased phosphorylation of GSK3B protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]
CTD PMID:18619545, PMID:25453207 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP oridonin inhibits the reaction [Kainic Acid results in decreased activity of GSR protein] CTD PMID:31430510 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 multiple interactions
decreases expression
EXP Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
Kainic Acid results in decreased expression of HCN1 mRNA; Kainic Acid results in decreased expression of HCN1 protein
CTD PMID:21905079 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Kainic Acid results in increased expression of HMOX1 mRNA CTD PMID:7655348 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Kainic Acid results in increased expression of HOMER1 mRNA CTD PMID:19700661 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hpca hippocalcin decreases response to substance ISO HPCA protein results in decreased susceptibility to Kainic Acid CTD PMID:15607944 NCBI chr 5:147,295,124...147,305,757
Ensembl chr 5:147,294,820...147,303,346
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Kainic Acid results in decreased expression of HSD11B1 mRNA CTD PMID:17997037 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein]; GYKI 52466 inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] CTD PMID:16686654 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Kainic Acid results in decreased expression of IDI1 mRNA CTD PMID:17997037 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Il10 interleukin 10 decreases expression EXP Kainic Acid results in decreased expression of IL10 protein CTD PMID:15591643 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A affects response to substance ISO IL12A protein affects the susceptibility to Kainic Acid CTD PMID:15474355 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
multiple interactions
EXP
ISO
Kainic Acid results in increased secretion of IL1B protein
Kainic Acid results in increased expression of IL1B mRNA; Kainic Acid results in increased expression of IL1B protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]
CTD PMID:7655348, PMID:11306611, PMID:21589914, PMID:31430510 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases response to substance
multiple interactions
increases expression
ISO
EXP
IL6 protein results in increased susceptibility to Kainic Acid
oridonin inhibits the reaction [Kainic Acid results in increased expression of IL6 protein]
Kainic Acid results in increased expression of IL6 mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]
CTD PMID:12836160, PMID:21589914, PMID:31430510 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
ISO Kainic Acid results in increased expression of ITGAM mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]
CTD PMID:21589914 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jagn1 jagunal homolog 1 decreases expression ISO Kainic Acid results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 4:145,399,885...145,404,605
Ensembl chr 4:145,399,913...145,404,617
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression
ISO
EXP
EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]] CTD PMID:18711747 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of JUN protein]
Kainic Acid results in increased expression of JUN mRNA; Kainic Acid results in increased expression of JUN protein
CTD PMID:8417141, PMID:15723099, PMID:17827730 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression
ISO
EXP
Kainic Acid results in decreased expression of JUNB mRNA
Kainic Acid results in increased expression of JUNB mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kalrn kalirin, RhoGEF kinase increases expression EXP Kainic Acid results in increased expression of KALRN mRNA CTD PMID:19700661 NCBI chr11:69,484,293...70,025,682
Ensembl chr11:69,484,293...70,025,633
JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 increases expression EXP Kainic Acid results in increased expression of KCNC2 protein CTD PMID:7643197 NCBI chr 7:54,978,453...55,159,362
Ensembl chr 7:54,980,120...55,159,351
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 decreases expression EXP Kainic Acid results in decreased expression of KCNC4 protein CTD PMID:21905079 NCBI chr 2:210,220,908...210,241,447
Ensembl chr 2:210,220,908...210,241,455
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Kainic Acid CTD PMID:26910900 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Kainic Acid results in decreased expression of KIF20A mRNA CTD PMID:17997037 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Klf10 Kruppel-like factor 10 decreases expression ISO Kainic Acid results in decreased expression of KLF10 mRNA CTD PMID:17997037 NCBI chr 7:77,156,010...77,162,096
Ensembl chr 7:77,156,006...77,162,148
JBrowse link
G Kng2 kininogen 2 multiple interactions EXP Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression EXP Kainic Acid results in increased expression of KRAS mRNA CTD PMID:19700661 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lep leptin decreases response to substance ISO LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lmo1 LIM domain only 1 decreases expression ISO Kainic Acid results in decreased expression of LMO1 mRNA CTD PMID:17997037 NCBI chr 1:173,728,183...173,764,288
Ensembl chr 1:173,728,184...173,764,250
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
EXP NADP inhibits the reaction [Kainic Acid results in increased expression of MAP1LC3B protein modified form] CTD PMID:32057834 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
increases expression
ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA] CTD PMID:21589914 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Kainic Acid results in decreased expression of MAP3K5 mRNA CTD PMID:17997037 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO Kainic Acid results in increased expression of MAPK3 mRNA CTD PMID:17997037 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mast3 microtubule associated serine/threonine kinase 3 decreases expression ISO Kainic Acid results in decreased expression of MAST3 mRNA CTD PMID:17997037 NCBI chr16:20,387,330...20,414,767
Ensembl chr16:20,395,845...20,414,767
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity
multiple interactions
ISO Kainic Acid results in increased activity of MMP9 protein
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]
CTD PMID:30772382 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance ISO MPDZ protein affects the susceptibility to Kainic Acid CTD PMID:14960011 NCBI chr 5:99,413,184...99,566,356
Ensembl chr 5:99,413,187...99,566,318
JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Kainic Acid results in increased expression of MPEG1 mRNA CTD PMID:17997037 NCBI chr 1:228,724,559...228,729,054
Ensembl chr 1:228,724,900...228,727,160
JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO Kainic Acid results in decreased expression of MSMO1 mRNA CTD PMID:17997037 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Mt1 metallothionein 1 decreases response to substance
increases expression
ISO
EXP
MT1 protein results in decreased susceptibility to Kainic Acid
Kainic Acid results in increased expression of MT1A mRNA
CTD PMID:7655348, PMID:10947810 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A decreases response to substance ISO MT2 protein results in decreased susceptibility to Kainic Acid CTD PMID:10947810 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myo5b myosin Vb decreases expression ISO Kainic Acid results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:70,426,865...70,729,985
Ensembl chr18:70,427,007...70,729,030
JBrowse link
G Myo9a myosin IXA increases expression ISO Kainic Acid results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 8:64,573,248...64,777,607
Ensembl chr 8:64,573,358...64,777,543
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP
ISO
Kainic Acid results in increased expression of NAIP mRNA; Kainic Acid results in increased expression of NAIP protein CTD PMID:12547647, PMID:15046874 NCBI chr 2:30,377,505...30,418,578 JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression
multiple interactions
EXP
ISO
Kainic Acid results in decreased expression of NCAM1 mRNA
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]
CTD PMID:19700661, PMID:30772382 NCBI chr 8:53,836,797...54,134,881
Ensembl chr 8:53,839,098...53,901,358
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO Kainic Acid affects the localization of NFE2L2 protein CTD PMID:18619545 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases expression
decreases expression
EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of NOS1 protein]
Kainic Acid results in increased expression of NOS1 mRNA; Kainic Acid results in increased expression of NOS1 protein
CTD PMID:17585341, PMID:18375135 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO
EXP
Kainic Acid results in increased expression of NOS2 mRNA
Kainic Acid results in increased expression of NOS2 mRNA; Kainic Acid results in increased expression of NOS2 protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
CTD PMID:17827730, PMID:18375135, PMID:21589914 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npy neuropeptide Y decreases response to substance
multiple interactions
increases expression
ISO
EXP
NPY protein results in decreased susceptibility to Kainic Acid
Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]
CTD PMID:9427505, PMID:15451008 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression
increases expression
ISO
EXP
Kainic Acid results in decreased expression of NR4A1 mRNA
Kainic Acid results in increased expression of NR4A1 mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression EXP
ISO
Kainic Acid results in increased expression of NR4A2 mRNA
Kainic Acid results in increased expression of NR4A2 protein
CTD PMID:19700661, PMID:24813937 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Kainic Acid results in increased expression of NR4A3 mRNA CTD PMID:19700661 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nrp2 neuropilin 2 affects response to substance ISO NRP2 protein affects the susceptibility to Kainic Acid CTD PMID:18657176 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Ntn1 netrin 1 increases expression EXP Kainic Acid results in increased expression of NTN1 mRNA CTD PMID:19700661 NCBI chr10:54,761,925...54,982,072
Ensembl chr10:54,761,871...54,967,585
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression EXP Kainic Acid results in increased expression of NTRK2 mRNA CTD PMID:19700661 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Nudcd2 NudC domain containing 2 increases expression ISO Kainic Acid results in increased expression of NUDCD2 mRNA CTD PMID:17997037 NCBI chr10:25,890,943...25,896,432
Ensembl chr10:25,890,943...25,896,432
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression ISO Kainic Acid results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr 7:36,643,916...36,660,334
Ensembl chr 7:36,643,916...36,660,141
JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression EXP Kainic Acid results in decreased expression of OTX2 mRNA CTD PMID:19700661 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691
JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 decreases expression EXP Kainic Acid results in decreased expression of PAK3 mRNA CTD PMID:19700661 NCBI chr  X:114,784,452...115,042,683
Ensembl chr  X:114,929,029...115,036,669
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity EXP Kainic Acid results in increased activity of PARP1 protein CTD PMID:28704930 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdyn prodynorphin multiple interactions
increases expression
EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Penk proenkephalin multiple interactions
increases expression
EXP Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141, PMID:9427505 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Pick1 protein interacting with PRKCA 1 decreases expression ISO Kainic Acid results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
G Pkp2 plakophilin 2 decreases expression ISO Kainic Acid results in decreased expression of PKP2 mRNA CTD PMID:17997037 NCBI chr11:88,912,163...88,972,213 JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression ISO Kainic Acid results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Ppif peptidylprolyl isomerase F increases response to substance ISO PPIF results in increased susceptibility to Kainic Acid CTD PMID:21378209 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression EXP Kainic Acid results in increased expression of PPP1R9B protein CTD PMID:17443789 NCBI chr10:82,800,704...82,816,735
Ensembl chr10:82,800,704...82,816,731
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases response to substance
increases expression
EXP
ISO
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; oridonin inhibits the reaction [Kainic Acid results in increased expression of PTGS2 protein]
[PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprostone; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Prostaglandin D2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]
Kainic Acid results in increased expression of PTGS2; Kainic Acid results in increased expression of PTGS2 mRNA; Kainic Acid results in increased expression of PTGS2 protein
CTD PMID:11168565, PMID:12618123, PMID:17827730, PMID:18834901, PMID:19700661, PMID:21589914, PMID:31430510 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Qk quaking increases expression ISO Kainic Acid results in increased expression of QK mRNA CTD PMID:17997037 NCBI chr 1:50,983,647...51,050,692 JBrowse link
G Rac1 Rac family small GTPase 1 increases expression EXP Kainic Acid results in increased expression of RAC1 mRNA CTD PMID:19700661 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression EXP Kainic Acid results in increased expression of RAD23A mRNA CTD PMID:19700661 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rasd1 ras related dexamethasone induced 1 decreases expression ISO Kainic Acid results in decreased expression of RASD1 mRNA CTD PMID:17997037 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rbfox1 RNA binding fox-1 homolog 1 increases response to substance ISO RBFOX1 gene mutant form results in increased susceptibility to Kainic Acid CTD PMID:21623373 NCBI chr10:8,312,961...10,437,778
Ensembl chr10:8,312,961...8,654,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA] CTD PMID:21589914 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rest RE1-silencing transcription factor increases expression
multiple interactions
EXP Kainic Acid results in increased expression of REST protein
Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
CTD PMID:21905079 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Kainic Acid results in decreased expression of RGS16 mRNA CTD PMID:17997037 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Rhoa ras homolog family member A increases expression EXP Kainic Acid results in increased expression of RHOA mRNA CTD PMID:19700661 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression ISO Kainic Acid results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Sap30l SAP30-like decreases expression ISO Kainic Acid results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr10:43,224,151...43,231,864
Ensembl chr10:43,224,269...43,231,611
JBrowse link
G Sema4d semaphorin 4D increases expression EXP Kainic Acid results in increased expression of SEMA4D mRNA CTD PMID:19700661 NCBI chr17:13,516,276...13,538,513
Ensembl chr17:13,488,376...13,553,974
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
increases expression
ISO Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Mecamylamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Phentolamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sfpq splicing factor proline and glutamine rich increases expression ISO Kainic Acid results in increased expression of SFPQ mRNA CTD PMID:17997037 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions EXP SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] CTD PMID:15723099 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Sirt1 sirtuin 1 decreases expression
increases expression
ISO
EXP
Kainic Acid results in decreased expression of SIRT1 protein
Kainic Acid results in increased expression of SIRT1 protein
CTD PMID:18538940 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression EXP Kainic Acid results in increased expression of SLC11A2 CTD PMID:16552559 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases expression ISO Kainic Acid results in decreased expression of SLC1A1 mRNA CTD PMID:17997037 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions
increases expression
ISO
EXP
[Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein
Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]
CTD PMID:19061913, PMID:28257918 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Kainic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc6a2 solute carrier family 6 member 2 increases response to substance ISO SLC6A2 protein results in increased susceptibility to Kainic Acid CTD PMID:15911120 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274
JBrowse link
G Slc8a3 solute carrier family 8 member A3 multiple interactions
increases expression
increases cleavage
EXP 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein]
Kainic Acid results in increased expression of SLC8A3 protein
CTD PMID:17585341, PMID:20928830 NCBI chr 6:104,889,500...105,099,408
Ensembl chr 6:104,891,376...105,097,054
JBrowse link
G Snrk SNF related kinase decreases expression ISO Kainic Acid results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 8:130,749,806...130,805,225
Ensembl chr 8:130,749,838...130,803,597
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Kainic Acid results in decreased expression of SOD1 protein CTD PMID:29208536 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression
EXP
ISO
Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in decreased expression of SOD2 mRNA; Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in increased expression of SOD2 protein
CTD PMID:10686417, PMID:29208536 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases expression EXP Kainic Acid results in increased expression of SPTAN1 protein modified form CTD PMID:22790971 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of SQSTM1 protein
NADP inhibits the reaction [Kainic Acid results in decreased expression of SQSTM1 protein]
CTD PMID:32057834 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Sst somatostatin decreases expression ISO Kainic Acid results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444
JBrowse link
G Tac1 tachykinin, precursor 1 decreases expression EXP Kainic Acid results in decreased expression of TAC1 protein CTD PMID:6205719 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of TIGAR protein
NADP inhibits the reaction [Kainic Acid results in decreased expression of TIGAR protein]
CTD PMID:32057834 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]; TNF protein promotes the reaction [Kainic Acid results in increased uptake of Cobalt]
oridonin inhibits the reaction [Kainic Acid results in increased expression of TNF protein]
Kainic Acid results in increased expression of TNF mRNA; Kainic Acid results in increased expression of TNF protein
CTD PMID:15869941, PMID:19700661, PMID:21589914, PMID:31430510 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Kainic Acid results in increased expression of TP53 protein CTD PMID:20955365 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trh thyrotropin releasing hormone decreases expression
increases expression
EXP Kainic Acid results in decreased expression of TRH mRNA
Kainic Acid results in increased expression of TRH mRNA
CTD PMID:10443546 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases expression EXP Kainic Acid results in decreased expression of TRHR protein CTD PMID:10443546 NCBI chr 7:83,113,641...83,153,520
Ensembl chr 7:83,113,672...83,153,519
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp increases expression ISO Kainic Acid results in increased expression of TYROBP mRNA CTD PMID:17997037 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression EXP Kainic Acid results in increased expression of UCHL1 protein CTD PMID:22790971 NCBI chr14:43,133,224...43,143,942
Ensembl chr14:43,133,218...43,143,973
JBrowse link
G Uhmk1 U2AF homology motif kinase 1 decreases expression ISO Kainic Acid results in decreased expression of UHMK1 mRNA CTD PMID:17997037 NCBI chr13:88,521,625...88,536,728
Ensembl chr13:88,521,625...88,536,728
JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression ISO Kainic Acid results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 1:94,346,513...94,404,362
Ensembl chr 1:94,346,514...94,404,211
JBrowse link
G Utp3 UTP3, small subunit processome component decreases expression ISO Kainic Acid results in decreased expression of UTP3 mRNA CTD PMID:17997037 NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 decreases expression EXP Kainic Acid results in decreased expression of VAMP7 mRNA CTD PMID:19700661 NCBI chr12:18,996,566...19,033,714
Ensembl chr12:18,996,591...19,030,381
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Kainic Acid results in decreased expression of VEGFA mRNA CTD PMID:17997037 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein increases expression ISO Kainic Acid results in increased expression of WFS1 mRNA CTD PMID:17997037 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor increases expression EXP Kainic Acid results in increased expression of XPA mRNA CTD PMID:19700661 NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
JBrowse link
G Zcchc7 zinc finger CCHC-type containing 7 increases expression ISO Kainic Acid results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 5:60,250,546...60,430,119
Ensembl chr 5:60,250,546...60,429,708
JBrowse link
levamisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
decreases activity
increases response to substance
ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]
Levamisole results in decreased activity of ALPL protein
ALPL gene mutant form results in increased susceptibility to Levamisole
[ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA
CTD PMID:18500657, PMID:27466191 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein] CTD PMID:32151603 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein] CTD PMID:32151603 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Levamisole results in increased expression of BAK1 protein CTD PMID:11139434 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Levamisole results in decreased expression of BCL2 protein CTD PMID:11139434 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein] CTD PMID:32151603 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Clu clusterin decreases expression ISO Levamisole results in decreased expression of CLU mRNA CTD PMID:11139434 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Dcc DCC netrin 1 receptor multiple interactions ISO DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole] CTD PMID:15148649 NCBI chr18:66,518,213...67,629,801
Ensembl chr18:66,523,120...67,224,566
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Levamisole results in decreased expression of EDN1 mRNA CTD PMID:11139434 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA] CTD PMID:18500657 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA CTD PMID:27466191 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein] CTD PMID:32151603 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein] CTD PMID:32151603 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO
EXP
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]
Levamisole results in increased expression of IFNG mRNA; Levamisole results in increased expression of IFNG protein
CTD PMID:10886398, PMID:23395935, PMID:32151603 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il15 interleukin 15 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein] CTD PMID:32151603 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein] CTD PMID:32151603 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein] CTD PMID:23395935, PMID:32151603 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il21 interleukin 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 2:123,965,021...123,972,356
Ensembl chr 2:123,965,021...123,972,356
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein] CTD PMID:23395935, PMID:32151603 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
EXP
ISO
Levamisole inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Levamisole results in decreased expression of IL4 mRNA
CTD PMID:10886398, PMID:32151603 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein] CTD PMID:23395935 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO Levamisole results in decreased expression of NOS3 protein CTD PMID:11139434 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA] CTD PMID:18500657 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15047127 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Levamisole results in decreased expression of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] CTD PMID:15047127 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of RORC protein] CTD PMID:32151603 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TBX21 protein] CTD PMID:32151603 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TGFB3 protein] CTD PMID:32151603 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein] CTD PMID:32151603 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR2 mRNA] CTD PMID:32151603 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr6 toll-like receptor 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR6 mRNA] CTD PMID:32151603 NCBI chr14:45,024,351...45,041,188
Ensembl chr14:45,024,351...45,046,446
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Levamisole results in decreased expression of TNF protein CTD PMID:17397355 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Levamisole results in decreased expression of TP53 mRNA; Levamisole results in decreased expression of TP53 protein CTD PMID:11139434 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
mebendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO Mebendazole results in decreased expression of ABCB1 mRNA; Mebendazole results in decreased expression of ABCB1 protein CTD PMID:28606429 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression ISO Mebendazole results in decreased expression of ABCC1 mRNA CTD PMID:28606429 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Mebendazole results in increased expression of AGER mRNA CTD PMID:24747151 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 decreases expression ISO Mebendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein] CTD PMID:18667591 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects response to substance
increases phosphorylation
multiple interactions
ISO BCL2 protein affects the susceptibility to Mebendazole
Mebendazole results in increased phosphorylation of BCL2 protein
[Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]
CTD PMID:18667591 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Mebendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO
EXP
Mebendazole results in increased expression of CYP1A1 mRNA; Mebendazole results in increased expression of CYP1A1 protein CTD PMID:9860486, PMID:12841937 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO
EXP
Mebendazole results in increased expression of CYP1A2 protein CTD PMID:12841937 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Mebendazole results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Mebendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO Mebendazole results in decreased expression of HES1 protein CTD PMID:32277947 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Mebendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK1 protein CTD PMID:20848085 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK3 protein CTD PMID:20848085 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK8 protein CTD PMID:20848085 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK9 protein CTD PMID:20848085 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Mebendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Mebendazole results in decreased expression of MYC mRNA; Mebendazole results in decreased expression of MYC protein CTD PMID:31207347, PMID:32277947 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Mebendazole results in increased expression of NLRP3 mRNA CTD PMID:24747151 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Notch1 notch receptor 1 decreases expression ISO Mebendazole results in decreased expression of NOTCH1 protein CTD PMID:32277947 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Mebendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO Mebendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO Mebendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Mebendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Mebendazole results in increased expression of S100A8 mRNA CTD PMID:24747151 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Mebendazole results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Slc47a1 solute carrier family 47 member 1 decreases expression ISO Mebendazole results in decreased expression of SLC47A1 mRNA CTD PMID:28606429 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Mebendazole binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
ISO U 0126 inhibits the reaction [Mebendazole results in increased secretion of TNF protein]
Mebendazole results in increased expression of TNF mRNA
CTD PMID:20848085, PMID:24747151 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Mebendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
oxamyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP
ISO
oxamyl results in decreased activity of ACHE protein CTD PMID:19934164, PMID:21251949, PMID:27132127 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions EXP [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Pgr progesterone receptor multiple interactions ISO oxamyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO
EXP
[Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl
[Calcium results in increased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl
CTD PMID:27132127 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
oxfendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
decreases activity
multiple interactions
ISO ABCG2 protein affects the transport of oxfendazole
oxfendazole results in decreased activity of ABCG2 protein
oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]
CTD PMID:15703302 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of AKR7A3 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Casp3 caspase 3 increases cleavage EXP oxfendazole results in increased cleavage of CASP3 protein CTD PMID:26558467 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP oxfendazole results in increased expression of CDKN1A protein CTD PMID:26558467 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek1 checkpoint kinase 1 affects expression EXP oxfendazole affects the expression of CHEK1 mRNA CTD PMID:26558467 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 protein; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GPX2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GSTM1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTM1 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression EXP oxfendazole results in decreased expression of MAD2L1 mRNA CTD PMID:26558467 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Mdm2 MDM2 proto-oncogene decreases phosphorylation
increases expression
EXP oxfendazole results in decreased phosphorylation of MDM2 protein
oxfendazole results in increased expression of MDM2 mRNA
CTD PMID:26558467 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression EXP oxfendazole results in decreased expression of MKI67 protein CTD PMID:26558467 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of NQO1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO oxfendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression EXP oxfendazole results in decreased expression of TOP2A protein CTD PMID:26558467 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP oxfendazole results in decreased expression of TP53 mRNA CTD PMID:26558467 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
pyrantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
Sudan I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions EXP
ISO
CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775, PMID:19358889 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases oxidation
ISO
EXP
CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
1-phenylazo-2-naphthol results in increased expression of CYP1A1 mRNA; 1-phenylazo-2-naphthol results in increased expression of CYP1A1 protein
1-phenylazo-2-naphthol promotes the reaction [aristolochic acid I results in increased expression of and results in increased activity of CYP1A1 protein]; 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of CYP1A1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
CTD PMID:12384524, PMID:15766589, PMID:17159775, PMID:18418879, PMID:23289503, PMID:24530354, PMID:26845733 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
increases oxidation
ISO
EXP
CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]
1-phenylazo-2-naphthol results in increased expression of CYP1A2 mRNA
1-phenylazo-2-naphthol affects the expression of and affects the activity of CYP1A2 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A2 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:17159775, PMID:26845733 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases oxidation ISO CYP1B1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
multiple interactions
ISO CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity
multiple interactions
EXP 1-phenylazo-2-naphthol results in decreased activity of CYP2C11 protein
[aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in decreased activity of CYP2C11 protein
CTD PMID:26845733 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases oxidation
ISO CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases oxidation ISO CYP2C8 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases oxidation
ISO CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO 1-phenylazo-2-naphthol results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP 1-phenylazo-2-naphthol results in increased expression of GSTP1 mRNA CTD PMID:2563599 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of NQO1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of NQO1 protein
1-phenylazo-2-naphthol results in increased expression of NQO1 mRNA
CTD PMID:23289503, PMID:26845733 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions EXP [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol CTD PMID:24530354 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
Sudan III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects localization
multiple interactions
ISO
EXP
sudan III affects the localization of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
CTD PMID:15585952, PMID:15788368, PMID:22287322 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:22287322 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
multiple interactions
ISO
EXP
sudan III results in increased expression of CYP1A1 mRNA
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
sudan III results in increased activity of CYP1A1 protein
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]
CTD PMID:18418879, PMID:20308224, PMID:22287322 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP sudan III results in increased expression of CYP1A2 protein CTD PMID:20308224 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein
sudan III results in decreased expression of CYP2B1 mRNA
CTD PMID:15788368 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein
sudan III results in decreased expression of CYP2B2 mRNA
CTD PMID:15788368 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein
sudan III results in decreased expression of CYP2C11 mRNA
CTD PMID:15788368 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A2 protein
sudan III results in decreased expression of CYP3A2 mRNA
CTD PMID:15788368 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
decreases expression
EXP [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein
sudan III results in decreased expression of CYP3A23-3A1 mRNA
CTD PMID:15788368 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP sudan III results in decreased expression of CYP4A1 mRNA CTD PMID:15585952 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 decreases expression EXP sudan III results in decreased expression of CYP4A2 mRNA CTD PMID:15585952 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP sudan III results in decreased expression of CYP4A3 mRNA CTD PMID:15585952 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP sudan III results in increased expression of NQO1 mRNA CTD PMID:20308224 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] CTD PMID:22287322 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO
EXP
sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]
CTD PMID:15585952, PMID:15788368 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO sudan III results in decreased expression of RXRA protein CTD PMID:15585952 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
Sudan IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein CTD PMID:18418879 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
suramin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]] CTD PMID:12044622 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Casp1 caspase 1 multiple interactions EXP Suramin inhibits the reaction [Glucose results in increased activity of CASP1 protein] CTD PMID:21832250 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]; Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3] CTD PMID:19448140 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit increases expression ISO Suramin results in increased expression of CHRNA7 protein CTD PMID:23516405 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein] CTD PMID:18612546 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Suramin results in decreased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Suramin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:22167199 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Suramin results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein] CTD PMID:9710602 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Suramin results in increased expression of FGF2 CTD PMID:8394679 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO Suramin results in increased expression of FGF5 CTD PMID:8394679 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fgf7 fibroblast growth factor 7 affects localization
multiple interactions
ISO Suramin affects the localization of FGF7 protein
Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein]
CTD PMID:15733146 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein] CTD PMID:15733146 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase decreases activity ISO Suramin results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases activity
ISO Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of IL10 protein]
Suramin results in decreased activity of IL10 protein
CTD PMID:15914193 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B increases expression ISO Suramin results in increased expression of IL12B protein CTD PMID:15914193 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]; Suramin inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein]
Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:24793913, PMID:24849676 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lmna lamin A/C multiple interactions ISO Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein] CTD PMID:23217256 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Suramin inhibits the reaction [2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]
CTD PMID:8758915, PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G P2rx3 purinergic receptor P2X 3 multiple interactions EXP Suramin inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein] CTD PMID:23666265 NCBI chr 3:72,403,992...72,447,801
Ensembl chr 3:72,403,993...72,447,801
JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein] CTD PMID:23516405 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases activity
multiple interactions
EXP
ISO
Suramin results in decreased activity of P2RY2 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]
CTD PMID:15654852, PMID:23516405 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] CTD PMID:18612546 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases expression
EXP
ISO
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein]
Suramin results in increased expression of SHC1 mRNA; Suramin results in increased expression of SHC1 protein
CTD PMID:9710602, PMID:21778425 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]; Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein]
[Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol
CTD PMID:18482975, PMID:23217256, PMID:24252177 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions EXP Suramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:23666265 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Suramin results in increased expression of TNF protein CTD PMID:15914193 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:18482975 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Suramin inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
thiabendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases expression EXP Thiabendazole results in decreased expression of ALB mRNA CTD PMID:18539377 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Casp3 caspase 3 increases activity EXP Thiabendazole results in increased activity of CASP3 protein CTD PMID:26748015 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity EXP Thiabendazole results in increased activity of CASP8 protein CTD PMID:26748015 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity EXP Thiabendazole results in increased activity of CASP9 protein CTD PMID:26748015 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Chmp5 charged multivesicular body protein 5 affects expression EXP Thiabendazole affects the expression of CHMP5 mRNA CTD PMID:18539377 NCBI chr 5:57,267,312...57,284,455
Ensembl chr 5:57,267,312...57,284,448
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
EXP
ISO
herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
Thiabendazole results in increased expression of CYP1A1 mRNA; Thiabendazole results in increased expression of CYP1A1 protein
CTD PMID:8900397, PMID:10103034, PMID:11226373, PMID:14987951, PMID:15110098 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
affects metabolic processing
decreases activity
ISO
EXP
beta-Naphthoflavone promotes the reaction [CYP1A2 protein affects the metabolism of Thiabendazole]
Thiabendazole results in increased expression of CYP1A2 mRNA; Thiabendazole results in increased expression of CYP1A2 protein
Thiabendazole results in decreased activity of CYP1A2 protein
CTD PMID:10936227, PMID:11124226, PMID:12920490, PMID:15110098, PMID:16261361, PMID:18539377, PMID:18570159 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Thiabendazole results in increased expression of CYP2B1 mRNA; Thiabendazole results in increased expression of CYP2B1 protein CTD PMID:15110098 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Thiabendazole results in increased expression of CYP2B2 mRNA; Thiabendazole results in increased expression of CYP2B2 protein CTD PMID:15110098 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Thiabendazole results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Thiabendazole results in increased expression of GADD45A mRNA CTD PMID:18539377 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions
ISO Thiabendazole results in increased activity of GCLC protein
[Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein
CTD PMID:11019651 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Thiabendazole results in increased expression of GSTP1 mRNA CTD PMID:15110098 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Thiabendazole results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Mpo myeloperoxidase increases metabolic processing ISO MPO protein results in increased metabolism of Thiabendazole metabolite CTD PMID:21513789 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nppb natriuretic peptide B increases expression EXP Thiabendazole results in increased expression of NPPB mRNA CTD PMID:18539377 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Thiabendazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 affects expression EXP Thiabendazole affects the expression of OXCT1 mRNA CTD PMID:18539377 NCBI chr 2:53,859,738...54,007,733
Ensembl chr 2:53,859,737...54,007,756
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP Thiabendazole results in increased expression of PFKFB1 mRNA CTD PMID:18539377 NCBI chr  X:23,092,143...23,145,923
Ensembl chr  X:23,092,159...23,144,324
JBrowse link
G Prkcb protein kinase C, beta increases expression EXP Thiabendazole results in increased expression of PRKCB mRNA CTD PMID:18539377 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Taf9b TATA-box binding protein associated factor 9b affects expression EXP Thiabendazole affects the expression of TAF9B mRNA CTD PMID:18539377 NCBI chr  X:77,281,234...77,295,238
Ensembl chr  X:77,281,210...77,295,426
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Thiabendazole results in increased expression of TP53 mRNA CTD PMID:18539377 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim3 tripartite motif-containing 3 increases expression EXP Thiabendazole results in increased expression of TRIM3 mRNA CTD PMID:18539377 NCBI chr 1:170,441,662...170,464,341
Ensembl chr 1:170,441,639...170,464,341
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression EXP Thiabendazole results in increased expression of UGDH mRNA CTD PMID:18539377 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Utrn utrophin increases expression ISO Thiabendazole results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,451,809...6,970,040
Ensembl chr 1:6,451,810...6,970,040
JBrowse link
tolnaftate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 multiple interactions ISO Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Tolnaftate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533, PMID:15284827 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533, PMID:15284827 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      application 19395
        pesticide 16281
          nematicide 3315
            antinematodal drug 476
              2-naphthol + 37
              amocarzine 0
              ascaridole 2
              carbendazim 52
              closantel 8
              coumaphos 5
              emodepside 0
              eprinomectin 3
              ethoprophos 2
              fenbendazole + 37
              flubendazole 15
              ivermectin 110
              kainic acid + 206
              levamisole + 36
              mebendazole 34
              methyl nonanoate 0
              oxamyl 5
              oxfendazole 19
              piperazine adipate 0
              pyrantel 1
              schaftoside 0
              suramin 31
              tetramisole 0
              thiabendazole 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      application 19395
        pharmaceutical 19266
          drug 19266
            antiinfective agent 13134
              antiparasitic agent 6075
                anthelminthic drug 896
                  antinematodal drug 476
                    2-naphthol + 37
                    amocarzine 0
                    ascaridole 2
                    carbendazim 52
                    closantel 8
                    coumaphos 5