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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antinematodal drug
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Accession:CHEBI:35444 term browser browse the term
Definition:A substance used in the treatment or control of nematode infestations.
Synonyms:related_synonym: antinematodal agent;   antinematodal drugs;   antinematodals


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2-naphthol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 affects sulfation EXP ABCC1 protein affects the sulfation of 2-naphthol CTD PMID:14742140 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions EXP [2-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Ar androgen receptor multiple interactions ISO 2-naphthol inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Ces1d carboxylesterase 1D affects metabolic processing ISO CES1 protein affects the metabolism of 2-naphthol CTD PMID:12837533 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases abundance ISO CYP1A1 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases abundance
affects binding
decreases activity
ISO CYP1A2 protein results in increased abundance of 2-naphthol
2-naphthol binds to CYP1A2 protein
2-naphthol results in decreased activity of CYP1A2 protein
CTD PMID:15916432, PMID:16243959, PMID:32278787 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions EXP [2-naphthol binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA CTD PMID:27837168 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases abundance ISO CYP2B6 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases abundance ISO CYP2E1 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases abundance ISO CYP3A4 protein results in increased abundance of 2-naphthol CTD PMID:16243959 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Sult4a1 sulfotransferase family 4A, member 1 increases metabolic processing ISO
EXP
SULT4A1 protein results in increased metabolism of 2-naphthol CTD PMID:12039030 NCBI chr15:84,076,097...84,105,754
Ensembl chr15:84,076,097...84,105,754
JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 2-naphthol binds to and results in decreased activity of THRB protein CTD PMID:18584933 NCBI chr14:17,659,225...18,040,097
Ensembl chr14:17,660,261...18,038,090
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B1 protein results in increased glucuronidation of 2-naphthol CTD PMID:8302279 NCBI chr 5:86,916,639...86,926,503
Ensembl chr 5:86,916,638...86,926,530
JBrowse link
ascaridole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 affects response to substance ISO ERCC6 protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr14:32,513,291...32,580,990
Ensembl chr14:32,513,521...32,580,990
JBrowse link
G Xpc xeroderma pigmentosum, complementation group C affects response to substance ISO XPC protein affects the susceptibility to ascaridole CTD PMID:22280988 NCBI chr 6:91,489,305...91,515,888
Ensembl chr 6:91,489,305...91,515,888
JBrowse link
carbendazim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 increases expression ISO carbendazim results in increased expression of ABI2 mRNA CTD PMID:22952946 NCBI chr 1:60,405,768...60,481,945
Ensembl chr 1:60,409,619...60,481,158
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha increases expression EXP carbendazim results in increased expression of ACACA mRNA CTD PMID:26071454 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) increases expression EXP carbendazim results in increased expression of AGPAT2 mRNA CTD PMID:26071454 NCBI chr 2:26,593,057...26,604,417
Ensembl chr 2:26,593,057...26,604,417
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
affects localization
EXP AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]
carbendazim affects the localization of AHR protein
CTD PMID:27286660 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Bag1 BCL2-associated athanogene 1 increases expression ISO carbendazim results in increased expression of BAG1 mRNA CTD PMID:22952946 NCBI chr 4:40,936,398...40,948,294
Ensembl chr 4:40,936,398...40,948,294
JBrowse link
G Bcl2l14 BCL2-like 14 (apoptosis facilitator) increases expression ISO carbendazim results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 6:134,396,329...134,438,724
Ensembl chr 6:134,396,318...134,438,736
JBrowse link
G Casp3 caspase 3 increases activity ISO carbendazim results in increased activity of CASP3 protein CTD PMID:30851412 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 3:145,070,260...145,099,443
Ensembl chr 3:145,070,263...145,099,443
JBrowse link
G Cldn11 claudin 11 multiple interactions ISO [carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein CTD PMID:28576679 NCBI chr 3:31,149,920...31,164,326
Ensembl chr 3:31,149,920...31,164,324
JBrowse link
G Clu clusterin decreases expression
increases expression
ISO carbendazim results in decreased expression of CLU mRNA
carbendazim results in increased expression of CLU mRNA
CTD PMID:22952946, PMID:27466211 NCBI chr14:65,968,483...65,981,548
Ensembl chr14:65,968,483...65,981,547
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression
ISO carbendazim results in increased activity of CYP19A1 protein
carbendazim results in increased expression of CYP19A1 mRNA
CTD PMID:14691014 NCBI chr 9:54,165,937...54,268,164
Ensembl chr 9:54,165,937...54,268,110
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO
EXP
carbendazim results in increased expression of CYP1A1 mRNA; carbendazim results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]; salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]
CTD PMID:10103034, PMID:21784029, PMID:27286660 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO carbendazim results in increased expression of CYP1A2 mRNA; carbendazim results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 increases expression ISO carbendazim results in increased expression of CYP2A6 mRNA CTD PMID:22310298 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO carbendazim results in increased expression of CYP2B6 mRNA CTD PMID:22310298 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity ISO carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression ISO carbendazim results in increased expression of CYP3A4 mRNA CTD PMID:22310298 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression EXP carbendazim results in increased expression of DGAT1 mRNA CTD PMID:26071454 NCBI chr15:76,502,012...76,512,021
Ensembl chr15:76,502,015...76,511,953
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression EXP carbendazim results in increased expression of DGAT2 mRNA CTD PMID:26071454 NCBI chr 7:99,153,663...99,182,713
Ensembl chr 7:99,153,658...99,182,719
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 2:25,352,290...25,356,389
Ensembl chr 2:25,352,276...25,356,359
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression ISO carbendazim results in decreased expression of ESR1 mRNA CTD PMID:28576679 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) decreases expression ISO carbendazim results in decreased expression of ESR2 mRNA CTD PMID:28576679 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Fank1 fibronectin type 3 and ankyrin repeat domains 1 increases expression ISO carbendazim results in increased expression of FANK1 mRNA CTD PMID:22952946 NCBI chr 7:133,776,836...133,881,536
Ensembl chr 7:133,776,861...133,881,532
JBrowse link
G Foxa2 forkhead box A2 increases expression EXP carbendazim results in increased expression of FOXA2 mRNA CTD PMID:26071454 NCBI chr 2:148,042,877...148,046,969
Ensembl chr 2:148,042,877...148,046,969
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Ift81 intraflagellar transport 81 decreases expression ISO carbendazim results in decreased expression of IFT81 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr 5:122,540,265...122,614,546
Ensembl chr 5:122,550,204...122,614,518
JBrowse link
G Il1b interleukin 1 beta increases expression EXP carbendazim results in increased expression of IL1B mRNA; carbendazim results in increased expression of IL1B protein CTD PMID:26071454 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 increases expression EXP carbendazim results in increased expression of IL6 mRNA; carbendazim results in increased expression of IL6 protein CTD PMID:26071454 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itga5 integrin alpha 5 (fibronectin receptor alpha) decreases expression ISO carbendazim results in decreased expression of ITGA5 mRNA CTD PMID:25530041 NCBI chr15:103,344,286...103,366,791
Ensembl chr15:103,344,286...103,366,763
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression ISO carbendazim results in decreased expression of ITGB1 mRNA CTD PMID:25530041 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Loxl1 lysyl oxidase-like 1 multiple interactions
increases expression
ISO 2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA CTD PMID:22382377 NCBI chr 9:58,287,723...58,313,212
Ensembl chr 9:58,287,738...58,313,186
JBrowse link
G Lpl lipoprotein lipase decreases expression EXP carbendazim results in decreased expression of LPL protein CTD PMID:30496565 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Lrrc6 leucine rich repeat containing 6 (testis) decreases expression ISO carbendazim results in decreased expression of LRRC6 mRNA CTD PMID:27466211 NCBI chr15:66,379,858...66,500,921
Ensembl chr15:66,379,858...66,500,910
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA CTD PMID:22382377 NCBI chr19:7,056,728...7,198,062
Ensembl chr19:7,056,810...7,198,057
JBrowse link
G Mfap3l microfibrillar-associated protein 3-like increases expression ISO carbendazim results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr 8:60,632,825...60,676,731
Ensembl chr 8:60,632,827...60,676,729
JBrowse link
G Mir128-1 microRNA 128-1 increases expression ISO carbendazim results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr 1:128,202,361...128,202,430
Ensembl chr 1:128,202,361...128,202,430
JBrowse link
G Mir423 microRNA 423 increases expression ISO carbendazim results in increased expression of MIR423 mRNA CTD PMID:32418910 NCBI chr11:77,078,064...77,078,172
Ensembl chr11:77,078,064...77,078,172
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO carbendazim results in decreased expression of MMP2 mRNA CTD PMID:25530041 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO carbendazim results in decreased expression of MMP9 mRNA CTD PMID:25530041 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression ISO carbendazim results in increased expression of NFE2L2 protein CTD PMID:30851412 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Pim1 proviral integration site 1 increases expression ISO carbendazim results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr17:29,490,785...29,496,111
Ensembl chr17:29,490,753...29,496,112
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO carbendazim results in decreased expression of PLAU mRNA CTD PMID:25530041 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Ptgds prostaglandin D2 synthase (brain) decreases expression ISO carbendazim results in decreased expression of PTGDS mRNA CTD PMID:22952946 NCBI chr 2:25,466,709...25,470,110
Ensembl chr 2:25,466,709...25,470,046
JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 increases expression ISO carbendazim results in increased expression of SERPINE2 mRNA CTD PMID:25530041 NCBI chr 1:79,794,317...79,858,665
Ensembl chr 1:79,794,197...79,861,180
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions ISO [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr15:89,493,013...89,560,261
Ensembl chr15:89,499,623...89,560,261
JBrowse link
G Sil1 endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae) decreases expression ISO carbendazim results in decreased expression of SIL1 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr18:35,266,396...35,499,390
Ensembl chr18:35,266,396...35,499,780
JBrowse link
G Sod3 superoxide dismutase 3, extracellular increases expression ISO carbendazim results in increased expression of SOD3 mRNA CTD PMID:27466211 NCBI chr 5:52,363,804...52,369,738
Ensembl chr 5:52,363,791...52,371,418
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP carbendazim results in increased expression of SREBF1 mRNA CTD PMID:26071454 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 decreases expression ISO carbendazim results in decreased expression of TBC1D5 mRNA CTD PMID:27466211 NCBI chr17:50,733,124...51,181,199
Ensembl chr17:50,733,124...51,179,352
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO carbendazim results in increased expression of TIMP1 mRNA CTD PMID:25530041 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 increases expression ISO carbendazim results in increased expression of TIMP2 mRNA CTD PMID:25530041 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
G Tnp1 transition protein 1 increases expression ISO carbendazim results in increased expression of TNP1 mRNA CTD PMID:28576679 NCBI chr 1:73,015,074...73,015,899
Ensembl chr 1:73,015,074...73,015,909
JBrowse link
G Tnp2 transition protein 2 increases expression ISO carbendazim results in increased expression of TNP2 mRNA CTD PMID:28576679 NCBI chr16:10,787,935...10,788,655
Ensembl chr16:10,787,936...10,788,660
JBrowse link
closantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A multiple interactions
decreases response to substance
EXP closantel results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
ABCB1A protein results in decreased susceptibility to closantel
CTD PMID:20513441 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 increases expression ISO closantel results in increased expression of BCL3 mRNA CTD PMID:22015988 NCBI chr 7:19,808,462...19,822,824
Ensembl chr 7:19,808,462...19,822,770
JBrowse link
G Slc25a31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 decreases activity ISO closantel results in decreased activity of SLC25A31 protein CTD PMID:26746582 NCBI chr 3:40,708,871...40,726,094
Ensembl chr 3:40,708,855...40,726,096
JBrowse link
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 decreases activity ISO closantel results in decreased activity of SLC25A4 protein CTD PMID:26746582 NCBI chr 8:46,207,168...46,211,062
Ensembl chr 8:46,206,797...46,211,284
JBrowse link
G Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 decreases activity ISO closantel results in decreased activity of SLC25A5 protein CTD PMID:26746582 NCBI chr  X:36,795,597...36,798,808
Ensembl chr  X:36,795,651...36,798,807
JBrowse link
G Thra thyroid hormone receptor alpha increases activity ISO closantel results in increased activity of THRA protein CTD PMID:22015988 NCBI chr11:98,740,776...98,769,006
Ensembl chr11:98,740,638...98,769,006
JBrowse link
G Thrb thyroid hormone receptor beta increases activity ISO closantel results in increased activity of THRB protein CTD PMID:22015988 NCBI chr14:17,659,225...18,040,097
Ensembl chr14:17,660,261...18,038,090
JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr 5:100,845,665...100,899,102
Ensembl chr 5:100,845,713...100,899,102
JBrowse link
G Lif leukemia inhibitory factor increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr11:4,257,568...4,272,514
Ensembl chr11:4,257,557...4,272,514
JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr11:98,927,800...98,974,942
Ensembl chr11:98,927,818...98,974,942
JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 3:50,364,936...50,499,087
Ensembl chr 3:49,892,526...50,443,614
JBrowse link
eprinomectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity EXP eprinomectin results in decreased activity of ABCB1A protein CTD PMID:17134887 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 1:13,139,105...13,374,227
Ensembl chr 1:13,139,105...13,374,083
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
ethoprophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO ethoprop metabolite results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions EXP ethoprophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
fenbendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B increases expression ISO Fenbendazole results in increased expression of AURKB protein CTD PMID:23411599 NCBI chr11:69,045,624...69,051,664
Ensembl chr11:69,045,647...69,051,664
JBrowse link
G Cbx5 chromobox 5 increases expression ISO Fenbendazole results in increased expression of CBX5 protein CTD PMID:23411599 NCBI chr15:103,191,546...103,239,904
Ensembl chr15:103,191,544...103,239,816
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression ISO Fenbendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Fenbendazole results in increased expression of CCND1 mRNA CTD PMID:23411599 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Fenbendazole results in increased expression of CCNE2 mRNA CTD PMID:23411599 NCBI chr 4:11,190,433...11,204,779
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Fenbendazole results in increased expression of CDK1 mRNA; Fenbendazole results in increased expression of CDK1 protein CTD PMID:23411599 NCBI chr10:69,335,146...69,352,912
Ensembl chr10:69,335,146...69,352,938
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO Fenbendazole results in increased expression of CDKN1A mRNA; Fenbendazole results in increased expression of CDKN1A protein CTD PMID:23411599 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases methylation
increases expression
decreases expression
ISO Fenbendazole results in increased methylation of CDKN2A gene
Fenbendazole results in increased expression of CDKN2A protein
Fenbendazole results in decreased expression of CDKN2A protein
CTD PMID:22659510, PMID:23411599 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B increases expression ISO Fenbendazole results in increased expression of CDKN2B mRNA CTD PMID:23411599 NCBI chr 4:89,306,289...89,311,032
Ensembl chr 4:89,306,299...89,311,039
JBrowse link
G Cdr2 cerebellar degeneration-related 2 increases expression ISO Fenbendazole results in increased expression of CDR2 mRNA CTD PMID:23411599 NCBI chr 7:120,957,036...120,982,312
Ensembl chr 7:120,957,036...120,982,312
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases secretion
multiple interactions
increases expression
ISO Fenbendazole results in increased secretion of CXCL8 protein
U 0126 inhibits the reaction [Fenbendazole results in increased secretion of CXCL8 protein]
Fenbendazole results in increased expression of CXCL8 protein
CTD PMID:20116850, PMID:20848085 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP Fenbendazole results in decreased activity of CYP1A2 protein CTD PMID:22048645 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Fenbendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Il6ra interleukin 6 receptor, alpha increases expression ISO Fenbendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196
JBrowse link
G Incenp inner centromere protein increases expression ISO Fenbendazole results in increased expression of INCENP protein CTD PMID:23411599 NCBI chr19:9,872,295...9,899,489
Ensembl chr19:9,872,296...9,899,551
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Fenbendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 increases expression ISO Fenbendazole results in increased expression of MDM2 mRNA CTD PMID:23411599 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression ISO Fenbendazole results in increased expression of MKI67 protein CTD PMID:23411599 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Fenbendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Tmem70 transmembrane protein 70 multiple interactions ISO [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of TMEM70 protein CTD PMID:27914986 NCBI chr 1:16,665,191...16,678,275
Ensembl chr 1:16,665,207...16,678,275
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
ISO Fenbendazole results in increased secretion of TNF protein
U 0126 inhibits the reaction [Fenbendazole results in increased secretion of TNF protein]
CTD PMID:20848085 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Fenbendazole results in increased expression of TP53 protein CTD PMID:23411599 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 multiple interactions ISO [Diethylnitrosamine co-treated with Fenbendazole] results in decreased expression of UBE2E2 protein CTD PMID:27914986 NCBI chr14:18,573,563...18,894,284
Ensembl chr14:18,573,575...18,894,267
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Fenbendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Wee1 WEE 1 homolog 1 (S. pombe) decreases expression ISO Fenbendazole results in decreased expression of WEE1 protein modified form CTD PMID:23411599 NCBI chr 7:110,122,059...110,143,299
Ensembl chr 7:110,122,046...110,143,286
JBrowse link
flubendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 decreases expression ISO flubendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 3:88,593,105...88,649,532
Ensembl chr 3:88,605,966...88,648,052
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases phosphorylation ISO flubendazole results in increased phosphorylation of BCL2 protein CTD PMID:32652169 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 increases phosphorylation ISO flubendazole results in increased phosphorylation of BCL2L1 protein CTD PMID:32652169 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO BAY 11-7085 affects the reaction [flubendazole results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; Cyclosporine inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [flubendazole results in increased cleavage of CASP3 protein] CTD PMID:32652169 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO flubendazole results in increased activity of MAPK8 protein CTD PMID:32652169 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 increases phosphorylation ISO flubendazole results in increased phosphorylation of MCL1 protein CTD PMID:32652169 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO flubendazole results in increased expression of PMAIP1 protein CTD PMID:32652169 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 decreases expression ISO flubendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO flubendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr 5:143,505,481...143,528,031
Ensembl chr 5:143,503,634...143,528,036
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases activity
ISO 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine affects the reaction [flubendazole results in increased activity of RELA protein]; BAY 11-7085 affects the reaction [flubendazole results in increased activity of RELA protein] CTD PMID:32652169 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO flubendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; flubendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Trp53 transformation related protein 53 increases activity ISO flubendazole results in increased activity of TP53 protein CTD PMID:32652169 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects binding
increases expression
decreases activity
multiple interactions
increases response to substance
increases export
decreases response to substance
affects abundance
affects response to substance
ISO
EXP
Ivermectin binds to ABCB1 protein
Ivermectin results in increased expression of ABCB1A mRNA
Ivermectin results in decreased activity of ABCB1A protein
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin inhibits the reaction [ABCB1A protein results in increased transport of bisbenzimide ethoxide trihydrochloride]; Ivermectin results in increased expression of and results in increased stability of ABCB1A mRNA; Ivermectin results in increased susceptibility to [ABCB1A protein results in increased transport of Xanthenes]
Ivermectin results in decreased activity of ABCB1 protein
Ivermectin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Ivermectin inhibits the reaction [ABCB1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
ABCB1A gene mutant form results in increased susceptibility to Ivermectin; ABCB1A protein mutant form results in increased susceptibility to Ivermectin
ABCB1A protein results in increased export of Ivermectin
ABCB1A protein results in decreased susceptibility to Ivermectin
ABCB1 protein affects the abundance of Ivermectin
ABCB1 gene polymorphism affects the susceptibility to Ivermectin
ABCB1 gene polymorphism affects the abundance of Ivermectin
CTD PMID:8917702, PMID:8949985, PMID:9144452, PMID:17134887, PMID:18633165, PMID:19161460, PMID:20513441, PMID:20595473, PMID:20630055, PMID:22024132, PMID:22834856, PMID:24998875, PMID:25865432 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B multiple interactions
increases expression
EXP [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to Ivermectin; Ivermectin results in increased expression of and results in increased stability of ABCB1B mRNA
Ivermectin results in increased expression of ABCB1B mRNA
CTD PMID:19161460, PMID:22024132, PMID:24998875 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 multiple interactions
decreases activity
ISO
EXP
Ivermectin inhibits the reaction [ABCC1 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
Ivermectin results in decreased activity of ABCC1 protein
CTD PMID:25865432 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression EXP Ivermectin results in increased expression of ABCC2 mRNA CTD PMID:24998875 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression EXP Ivermectin results in increased expression of ABCG2 mRNA CTD PMID:24998875 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions
decreases expression
affects expression
EXP
ISO
Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein]
Ivermectin results in decreased expression of ACACA mRNA
Ivermectin affects the expression of ACACA mRNA
Ivermectin inhibits the reaction [Palmitic Acid results in decreased phosphorylation of ACACA protein]
CTD PMID:30738135, PMID:31199990 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ADCY7 mRNA CTD PMID:16861626 NCBI chr 8:88,272,190...88,329,965
Ensembl chr 8:88,272,403...88,329,962
JBrowse link
G Adm adrenomedullin decreases expression EXP Ivermectin results in decreased expression of ADM mRNA CTD PMID:28942281 NCBI chr 7:110,627,657...110,629,820
Ensembl chr 7:110,627,661...110,629,820
JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression EXP Ivermectin results in increased expression of ALDH1L2 mRNA CTD PMID:28942281 NCBI chr10:83,487,447...83,534,146
Ensembl chr10:83,487,450...83,534,140
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression EXP Ivermectin results in increased expression of ANGPTL6 mRNA CTD PMID:28942281 NCBI chr 9:20,873,808...20,879,822
Ensembl chr 9:20,873,808...20,879,727
JBrowse link
G Arl4c ADP-ribosylation factor-like 4C multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of ARL4C mRNA CTD PMID:16861626 NCBI chr 1:88,698,225...88,702,191
Ensembl chr 1:88,673,125...88,702,221
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO
EXP
Ivermectin results in increased expression of ATF4 mRNA CTD PMID:28942281 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP
ISO
Ivermectin results in increased expression of ATF5 mRNA CTD PMID:28942281 NCBI chr 7:44,812,256...44,816,658
Ensembl chr 7:44,812,256...44,816,658
JBrowse link
G Atf6 activating transcription factor 6 increases expression EXP Ivermectin results in increased expression of ATF6 mRNA CTD PMID:28942281 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Bag3 BCL2-associated athanogene 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of BAG3 mRNA CTD PMID:16861626 NCBI chr 7:128,523,583...128,546,981
Ensembl chr 7:128,523,616...128,546,981
JBrowse link
G Bax BCL2-associated X protein increases expression ISO Ivermectin results in increased expression of BAX protein CTD PMID:28811376 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid results in increased expression of BBC3 mRNA] CTD PMID:24658405 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 decreases expression EXP Ivermectin results in decreased expression of BNIP3 mRNA CTD PMID:28942281 NCBI chr 7:138,890,836...138,909,506
Ensembl chr 7:138,890,836...138,909,519
JBrowse link
G Camp cathelicidin antimicrobial peptide decreases expression ISO Ivermectin results in decreased expression of CAMP mRNA; Ivermectin results in decreased expression of CAMP protein CTD PMID:28653460 NCBI chr 9:109,847,377...109,849,456
Ensembl chr 9:109,847,379...109,849,617
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO Thioctic Acid inhibits the reaction [Ivermectin results in decreased activity of CAT protein] CTD PMID:28880400 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCL3 protein CTD PMID:16861626 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccr7 chemokine (C-C motif) receptor 7 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CCR7 mRNA CTD PMID:16861626 NCBI chr11:99,144,199...99,155,077
Ensembl chr11:99,144,196...99,155,077
JBrowse link
G Cct3 chaperonin containing Tcp1, subunit 3 (gamma) multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of CCT3 mRNA CTD PMID:16861626 NCBI chr 3:88,297,135...88,321,766
Ensembl chr 3:88,297,116...88,321,767
JBrowse link
G Cd36 CD36 molecule affects expression EXP Ivermectin affects the expression of CD36 mRNA CTD PMID:31199990 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cdh1 cadherin 1 increases expression ISO
EXP
Ivermectin results in increased expression of CDH1 CTD PMID:26078298 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO Ivermectin results in increased expression of CDKN1A protein CTD PMID:28811376 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Ivermectin results in increased expression of CDKN1B protein CTD PMID:28811376 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha multiple interactions
affects expression
EXP Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of CEBPA mRNA] CTD PMID:31199990 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 increases expression EXP Ivermectin results in increased expression of COX6A2 mRNA; Ivermectin results in increased expression of COX6A2 protein CTD PMID:28942281 NCBI chr 7:128,205,435...128,206,366
Ensembl chr 7:128,205,435...128,206,387
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions
affects expression
ISO
EXP
Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of CPT1A mRNA]
Ivermectin affects the expression of CPT1A mRNA
CTD PMID:30738135, PMID:31199990 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Crp C-reactive protein, pentraxin-related increases expression ISO Ivermectin results in increased expression of CRP protein CTD PMID:8555762 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of CTSL mRNA CTD PMID:16861626 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
decreases expression
ISO [Ivermectin co-treated with Albendazole] results in increased expression of CXCL8 protein
Ivermectin results in decreased expression of CXCL8 mRNA; Ivermectin results in decreased expression of CXCL8 protein
CTD PMID:16861626, PMID:28653460 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
EXP Ivermectin results in decreased activity of CYP1A1 protein
Ivermectin results in increased expression of CYP1A1 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Ivermectin results in increased expression of CYP1A2 mRNA CTD PMID:24998875 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity EXP Ivermectin results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity EXP Ivermectin results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity
increases expression
EXP Ivermectin results in decreased activity of CYP2B10 protein
Ivermectin results in increased expression of CYP2B10 mRNA
CTD PMID:18420780, PMID:24998875 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity EXP Ivermectin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO Ivermectin results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity ISO Ivermectin results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 decreases activity EXP
ISO
Ivermectin results in decreased activity of CYP2D22 protein
Ivermectin results in decreased activity of CYP2D6 protein
CTD PMID:11124226, PMID:18420780 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP Ivermectin results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity
increases expression
EXP
ISO
Ivermectin results in decreased activity of CYP3A11 protein
Ivermectin results in decreased activity of CYP3A4 protein
Ivermectin results in increased expression of CYP3A11 mRNA
CTD PMID:11124226, PMID:18420780, PMID:24998875 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
affects expression
EXP
ISO
Ivermectin results in increased expression of DDIT3 mRNA
Ivermectin promotes the reaction [Palmitic Acid results in increased expression of DDIT3 protein]
Ivermectin affects the expression of DDIT3 mRNA
CTD PMID:28942281, PMID:30738135, PMID:31199990 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA CTD PMID:16861626 NCBI chr 8:83,608,175...83,612,653
Ensembl chr 8:83,608,193...83,612,653
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA CTD PMID:16861626 NCBI chr14:66,802,864...66,911,041
Ensembl chr14:66,802,864...66,868,688
JBrowse link
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 increases expression ISO Ivermectin results in increased expression of EDEM1 mRNA CTD PMID:28942281 NCBI chr 6:108,824,045...108,859,356
Ensembl chr 6:108,828,641...108,859,356
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression EXP Ivermectin results in decreased expression of EGLN3 mRNA CTD PMID:28942281 NCBI chr12:54,178,981...54,203,874
Ensembl chr12:54,178,981...54,203,860
JBrowse link
G Esr1 estrogen receptor 1 (alpha) increases expression ISO
EXP
Ivermectin results in increased expression of ESR1 CTD PMID:26078298 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte affects expression
multiple interactions
EXP Ivermectin affects the expression of FABP4 mRNA
Rosiglitazone affects the reaction [Ivermectin affects the expression of FABP4 mRNA]
CTD PMID:31199990 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fasn fatty acid synthase affects expression EXP Ivermectin affects the expression of FASN mRNA CTD PMID:31199990 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression EXP Ivermectin results in increased expression of GDF15 mRNA CTD PMID:28942281 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Gem GTP binding protein (gene overexpressed in skeletal muscle) multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of GEM mRNA CTD PMID:16861626 NCBI chr 4:11,704,447...11,714,993
Ensembl chr 4:11,704,457...11,714,752
JBrowse link
G Glra1 glycine receptor, alpha 1 subunit increases activity
multiple interactions
affects activity
ISO Ivermectin results in increased activity of GLRA1 protein mutant form
Ivermectin affects the reaction [Glycine affects the activity of GLRA1 protein mutant form]
Ivermectin affects the activity of GLRA1 protein mutant form
CTD PMID:25231486, PMID:27958714 NCBI chr11:55,514,239...55,608,198
Ensembl chr11:55,514,238...55,608,198
JBrowse link
G Glra3 glycine receptor, alpha 3 subunit affects expression EXP Ivermectin affects the expression of GLRA3 mRNA CTD PMID:31199990 NCBI chr 8:55,940,418...56,130,070
Ensembl chr 8:55,940,460...56,130,070
JBrowse link
G Glrb glycine receptor, beta subunit affects expression EXP Ivermectin affects the expression of GLRB mRNA CTD PMID:31199990 NCBI chr 3:80,843,598...80,913,660
Ensembl chr 3:80,843,599...80,913,660
JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of GPR183 mRNA CTD PMID:16861626 NCBI chr14:121,952,331...121,965,193
Ensembl chr14:121,952,551...121,965,195
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AA1 mRNA CTD PMID:16861626 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSP90AB1 mRNA CTD PMID:16861626 NCBI chr17:45,567,778...45,573,261
Ensembl chr17:45,567,775...45,573,271
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions
increases expression
ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of HSPA1A mRNA] CTD PMID:28880400 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Hspa4 heat shock protein 4 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA4 mRNA CTD PMID:16861626 NCBI chr11:53,259,814...53,300,479
Ensembl chr11:53,259,814...53,300,457
JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Ivermectin results in increased expression of HSPA5 protein CTD PMID:30738135 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa8 heat shock protein 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPA8 mRNA CTD PMID:16861626 NCBI chr 9:40,801,276...40,805,202
Ensembl chr 9:40,800,984...40,810,087
JBrowse link
G Hspa9 heat shock protein 9 increases expression ISO
EXP
Ivermectin results in increased expression of HSPA9 mRNA CTD PMID:28942281 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) multiple interactions
increases expression
ISO
EXP
[Ivermectin co-treated with Albendazole] results in increased expression of HSPD1 mRNA
Ivermectin results in increased expression of HSPD1 mRNA
CTD PMID:16861626, PMID:28942281 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPE1 mRNA CTD PMID:16861626 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of HSPH1 mRNA CTD PMID:16861626 NCBI chr 5:149,616,843...149,636,498
Ensembl chr 5:149,614,287...149,636,376
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
increases expression
ISO Thioctic Acid inhibits the reaction [Ivermectin results in increased expression of IGFBP3 mRNA] CTD PMID:28880400 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL10 protein CTD PMID:16861626 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1A protein CTD PMID:16861626 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1r1 interleukin 1 receptor, type I multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of IL1R1 mRNA CTD PMID:16861626 NCBI chr 1:40,222,480...40,316,201
Ensembl chr 1:40,225,080...40,317,257
JBrowse link
G Ins1 insulin I multiple interactions EXP Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACACA protein]; Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein] CTD PMID:31199990 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Lonp1 lon peptidase 1, mitochondrial increases expression ISO
EXP
Ivermectin results in increased expression of LONP1 mRNA CTD PMID:28942281 NCBI chr17:56,614,297...56,626,903
Ensembl chr17:56,614,297...56,626,887
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of MAP3K8 mRNA CTD PMID:16861626 NCBI chr18:4,331,325...4,352,953
Ensembl chr18:4,331,327...4,353,015
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein] CTD PMID:19168156 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein] CTD PMID:19168156 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein] CTD PMID:19168156 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mxd1 MAX dimerization protein 1 multiple interactions ISO
EXP
Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 6:86,647,044...86,669,234
Ensembl chr 6:86,647,042...86,669,161
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Ivermectin results in decreased expression of NANOG mRNA; Ivermectin results in decreased expression of NANOG protein CTD PMID:29257278 NCBI chr 6:122,707,489...122,714,633
Ensembl chr 6:122,707,489...122,714,633
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 1:13,139,105...13,374,227
Ensembl chr 1:13,139,105...13,374,083
JBrowse link
G Ndrg1 N-myc downstream regulated gene 1 decreases expression EXP Ivermectin results in decreased expression of NDRG1 mRNA CTD PMID:28942281 NCBI chr15:66,929,318...66,969,641
Ensembl chr15:66,929,318...66,969,640
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein] CTD PMID:19168156 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nppb natriuretic peptide type B multiple interactions ISO Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; Ivermectin inhibits the reaction [EDN1 protein results in increased expression of NPPB protein] CTD PMID:28942281 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 decreases expression ISO Ivermectin results in decreased expression of NQO1 mRNA; Ivermectin results in decreased expression of NQO1 protein CTD PMID:22021338 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression
affects expression
ISO
EXP
Ivermectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
Ivermectin results in increased expression of NR1H4 mRNA
Ivermectin affects the expression of NR1H4 mRNA
CTD PMID:27773686, PMID:30738135, PMID:31199990 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression EXP Ivermectin results in increased expression of NUPR1 mRNA CTD PMID:28942281 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861
JBrowse link
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 multiple interactions
increases activity
EXP
ISO
Ivermectin promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
Ivermectin results in increased activity of P2RX4 protein
CTD PMID:19560503, PMID:21638035, PMID:30545933 NCBI chr 5:122,707,518...122,729,739
Ensembl chr 5:122,707,544...122,729,738
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases expression ISO Ivermectin results in increased expression of PARP1 protein modified form CTD PMID:28811376 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pfkl phosphofructokinase, liver, B-type decreases expression EXP Ivermectin results in decreased expression of PFKL mRNA CTD PMID:28942281 NCBI chr10:77,986,947...78,009,807
Ensembl chr10:77,986,947...78,010,083
JBrowse link
G Pou5f1 POU domain, class 5, transcription factor 1 decreases expression ISO Ivermectin results in decreased expression of POU5F1 mRNA; Ivermectin results in decreased expression of POU5F1 protein CTD PMID:29257278 NCBI chr17:35,506,032...35,510,777
Ensembl chr17:35,506,018...35,510,772
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
decreases expression
ISO Ivermectin inhibits the reaction [Palmitic Acid results in increased expression of PPARA mRNA]
Ivermectin results in decreased expression of PPARA mRNA
CTD PMID:30738135 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
affects expression
EXP Ivermectin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]; Rosiglitazone affects the reaction [Ivermectin affects the expression of PPARG mRNA] CTD PMID:31199990 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ppid peptidylprolyl isomerase D (cyclophilin D) multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPID mRNA CTD PMID:16861626 NCBI chr 3:79,591,337...79,603,810
Ensembl chr 3:79,591,342...79,603,650
JBrowse link
G Ppif peptidylprolyl isomerase F (cyclophilin F) multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA CTD PMID:16861626 NCBI chr14:25,693,574...25,700,468
Ensembl chr14:25,694,154...25,700,468
JBrowse link
G Ptges3 prostaglandin E synthase 3 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of PTGES3 mRNA CTD PMID:16861626 NCBI chr10:128,058,982...128,077,254
Ensembl chr10:128,058,954...128,077,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; Ivermectin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein] CTD PMID:19168156 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rpp14 ribonuclease P 14 subunit increases expression EXP Ivermectin results in increased expression of RPP14 mRNA CTD PMID:28942281 NCBI chr14:8,080,313...8,091,846
Ensembl chr14:8,080,367...8,091,834
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 decreases expression EXP Ivermectin results in decreased expression of SERPINE1 mRNA CTD PMID:28942281 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sin3a transcriptional regulator, SIN3A (yeast) multiple interactions ISO
EXP
Ivermectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 9:57,071,991...57,128,368
Ensembl chr 9:57,072,040...57,128,366
JBrowse link
G Skap2 src family associated phosphoprotein 2 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of SKAP2 mRNA CTD PMID:16861626 NCBI chr 6:51,859,165...52,012,549
Ensembl chr 6:51,857,422...52,012,549
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 decreases expression EXP Ivermectin results in decreased expression of SLC2A1 mRNA CTD PMID:28942281 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983
JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 affects expression EXP Ivermectin affects the expression of SLC2A4 mRNA CTD PMID:31199990 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 decreases expression ISO Ivermectin results in decreased expression of SOX2 mRNA; Ivermectin results in decreased expression of SOX2 protein CTD PMID:29257278 NCBI chr 3:34,649,995...34,652,461
Ensembl chr 3:34,650,405...34,652,461
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 NCBI chr11:116,530,836...116,536,675
Ensembl chr11:116,530,925...116,536,674
Ensembl chr11:116,530,925...116,536,674
JBrowse link
G St13 suppression of tumorigenicity 13 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of ST13 mRNA CTD PMID:16861626 NCBI chr15:81,365,044...81,399,694
Ensembl chr15:81,363,669...81,400,077
JBrowse link
G Tcp1 t-complex protein 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in increased expression of TCP1 mRNA CTD PMID:16861626 NCBI chr17:12,916,329...12,925,067
Ensembl chr17:12,915,701...12,925,067
JBrowse link
G Tfrc transferrin receptor decreases expression EXP Ivermectin results in decreased expression of TFRC mRNA CTD PMID:28942281 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TGIF1 mRNA CTD PMID:16861626 NCBI chr17:70,844,205...70,853,532
Ensembl chr17:70,844,205...70,853,546
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Ivermectin results in decreased expression of TLR2 protein CTD PMID:28653460 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO Ivermectin results in decreased expression of TLR4 mRNA CTD PMID:28653460 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Ivermectin results in decreased expression of TNF mRNA CTD PMID:28653460 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP Ivermectin results in increased expression of TRIB3 mRNA CTD PMID:28942281 NCBI chr 2:152,337,425...152,344,060
Ensembl chr 2:152,337,422...152,344,032
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Ivermectin inhibits the reaction [geranylgeranic acid affects the localization of TP53 protein mutant form] CTD PMID:24658405 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions ISO [Ivermectin co-treated with Albendazole] results in decreased expression of TSC22D1 mRNA CTD PMID:16861626 NCBI chr14:76,414,961...76,507,765
Ensembl chr14:76,414,961...76,507,765
JBrowse link
kainic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases expression ISO Kainic Acid results in increased expression of ABCB1A mRNA; Kainic Acid results in increased expression of ABCB1A protein CTD PMID:14706787 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B increases expression ISO Kainic Acid results in increased expression of ABCB1B mRNA; Kainic Acid results in increased expression of ABCB1B protein CTD PMID:14706787 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression EXP Kainic Acid results in increased expression of ABCG2 mRNA CTD PMID:17997037 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Aco2 aconitase 2, mitochondrial multiple interactions
decreases activity
ISO 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Kainic Acid results in decreased activity of ACO2 protein] CTD PMID:11520895 NCBI chr15:81,872,463...81,915,137
Ensembl chr15:81,872,309...81,915,133
JBrowse link
G Acp1 acid phosphatase 1, soluble decreases expression EXP Kainic Acid results in decreased expression of ACP1 mRNA CTD PMID:17997037 NCBI chr12:30,893,326...30,911,619
Ensembl chr12:30,893,326...30,911,589
JBrowse link
G Adk adenosine kinase increases expression EXP Kainic Acid results in increased expression of ADK mRNA CTD PMID:17997037 NCBI chr14:21,052,574...21,448,569
Ensembl chr14:21,052,574...21,448,569
JBrowse link
G Adnp activity-dependent neuroprotective protein multiple interactions
decreases expression
ISO Enzyme Inhibitors inhibits the reaction [Kainic Acid results in decreased expression of ADNP protein]
Kainic Acid results in decreased expression of ADNP mRNA; Kainic Acid results in decreased expression of ADNP protein
CTD PMID:18375135 NCBI chr 2:168,180,965...168,207,112
Ensembl chr 2:168,180,986...168,207,112
JBrowse link
G Adra1b adrenergic receptor, alpha 1b increases response to substance EXP ADRA1B protein results in increased susceptibility to Kainic Acid CTD PMID:19125850 NCBI chr11:43,774,605...43,901,250
Ensembl chr11:43,774,606...43,901,210
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
ISO NADP inhibits the reaction [Kainic Acid results in increased expression of AIF1 protein] CTD PMID:32057834 NCBI chr17:35,170,986...35,176,083
Ensembl chr17:35,170,991...35,176,068
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 increases localization
multiple interactions
EXP Kainic Acid results in increased localization of AIFM1 protein
Minocycline inhibits the reaction [Kainic Acid results in increased localization of AIFM1 protein]
CTD PMID:16469440 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Alox12e arachidonate lipoxygenase, epidermal increases expression EXP Kainic Acid results in increased expression of ALOX12E mRNA CTD PMID:17997037 NCBI chr11:70,315,610...70,322,720
Ensembl chr11:70,315,610...70,322,628
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO Kainic Acid results in increased expression of ALOX5AP mRNA CTD PMID:19700661 NCBI chr 5:149,265,004...149,288,153
Ensembl chr 5:149,264,767...149,288,153
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression EXP Kainic Acid results in increased expression of APAF1 mRNA CTD PMID:17997037 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 multiple interactions ISO [Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA CTD PMID:16120186 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Apoe apolipoprotein E decreases expression EXP Kainic Acid results in decreased expression of APOE mRNA CTD PMID:17997037 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G Arc activity regulated cytoskeletal-associated protein increases expression ISO
EXP
Kainic Acid results in increased expression of ARC mRNA; Kainic Acid results in increased expression of ARC protein CTD PMID:17632064, PMID:30557575 NCBI chr15:74,669,081...74,672,570
Ensembl chr15:74,669,083...74,672,570
JBrowse link
G Atf7ip activating transcription factor 7 interacting protein decreases expression ISO Kainic Acid results in decreased expression of ATF7IP mRNA CTD PMID:19700661 NCBI chr 6:136,518,789...136,610,850
Ensembl chr 6:136,506,167...136,610,862
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO Kainic Acid results in increased expression of ATG5 protein
NADP inhibits the reaction [Kainic Acid results in increased expression of ATG5 protein]
CTD PMID:32057834 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G B4galt2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 decreases expression EXP Kainic Acid results in decreased expression of B4GALT2 mRNA CTD PMID:17997037 NCBI chr 4:117,873,000...117,883,519
Ensembl chr 4:117,869,260...117,883,487
JBrowse link
G Bag3 BCL2-associated athanogene 3 increases expression ISO Kainic Acid results in increased expression of BAG3 mRNA CTD PMID:19700661 NCBI chr 7:128,523,583...128,546,981
Ensembl chr 7:128,523,616...128,546,981
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
ISO
EXP
Kainic Acid results in increased expression of BAX mRNA; Kainic Acid results in increased expression of BAX protein
oridonin inhibits the reaction [Kainic Acid results in increased expression of BAX mRNA]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]]
Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of BAX protein]
CTD PMID:18711747, PMID:19700661, PMID:25453207, PMID:31430510 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
EXP
ISO
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased expression of BCL2 protein]
oridonin inhibits the reaction [Kainic Acid results in decreased expression of BCL2 mRNA]
CTD PMID:25453207, PMID:31430510 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions
increases expression
ISO [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]
Kainic Acid results in increased expression of BDNF mRNA; Kainic Acid results in increased expression of BDNF protein
CTD PMID:1641125, PMID:9073163, PMID:11279263, PMID:16166269, PMID:17827730, PMID:19700661 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions
increases expression
ISO NADP inhibits the reaction [Kainic Acid results in increased expression of BECN1 protein] CTD PMID:32057834 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G C1qb complement component 1, q subcomponent, beta polypeptide increases expression EXP Kainic Acid results in increased expression of C1QB mRNA CTD PMID:17997037 NCBI chr 4:136,880,126...136,886,200
Ensembl chr 4:136,880,129...136,886,187
JBrowse link
G C4b complement component 4B (Chido blood group) increases expression EXP Kainic Acid results in increased expression of C4B mRNA CTD PMID:17997037 NCBI chr17:34,728,139...34,743,902
Ensembl chr17:34,728,380...34,743,882
JBrowse link
G Calb1 calbindin 1 decreases expression EXP Kainic Acid results in decreased expression of CALB1 mRNA CTD PMID:17997037 NCBI chr 4:15,881,264...15,906,709
Ensembl chr 4:15,881,264...15,908,064
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression EXP Kainic Acid results in decreased expression of CAMK4 mRNA CTD PMID:17997037 NCBI chr18:32,934,941...33,195,767
Ensembl chr18:32,934,931...33,191,228
JBrowse link
G Capns1 calpain, small subunit 1 increases expression ISO Kainic Acid results in increased expression of CAPNS1 mRNA CTD PMID:19700661 NCBI chr 7:30,186,934...30,198,883
Ensembl chr 7:30,186,936...30,198,811
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression
EXP
ISO
Kainic Acid results in increased activity of CASP3 protein
oridonin inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]
Kainic Acid results in increased cleavage of CASP3 protein
Kainic Acid results in increased expression of CASP3 mRNA; Kainic Acid results in increased expression of CASP3 protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]]; Minocycline inhibits the reaction [Kainic Acid results in increased activity of CASP3 protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased cleavage of CASP3 protein]
CTD PMID:16469440, PMID:18711747, PMID:19700661, PMID:25453207, PMID:31430510 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cat catalase decreases expression
decreases activity
multiple interactions
EXP
ISO
Kainic Acid results in decreased expression of CAT mRNA; Kainic Acid results in decreased expression of CAT protein
Kainic Acid results in decreased activity of CAT protein
oridonin inhibits the reaction [Kainic Acid results in decreased activity of CAT protein]
CTD PMID:29208536, PMID:31430510 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cck cholecystokinin decreases expression ISO Kainic Acid results in decreased expression of CCK protein CTD PMID:7774662 NCBI chr 9:121,489,824...121,495,694
Ensembl chr 9:121,489,824...121,495,694
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression ISO Kainic Acid results in increased expression of CCL2 mRNA CTD PMID:19700661 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Kainic Acid results in increased expression of CCNE1 protein CTD PMID:12941380 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534
JBrowse link
G Cd68 CD68 antigen increases expression ISO Kainic Acid results in increased expression of CD68 mRNA CTD PMID:19700661 NCBI chr11:69,664,213...69,666,170
Ensembl chr11:69,664,213...69,666,153
JBrowse link
G Cdc42 cell division cycle 42 increases expression ISO Kainic Acid results in increased expression of CDC42 mRNA CTD PMID:19700661 NCBI chr 4:137,319,696...137,357,759
Ensembl chr 4:137,319,696...137,357,720
JBrowse link
G Cdh13 cadherin 13 increases expression EXP Kainic Acid results in increased expression of CDH13 mRNA CTD PMID:17997037 NCBI chr 8:118,140,017...119,324,929
Ensembl chr 8:118,283,733...119,324,921
JBrowse link
G Cdk2 cyclin-dependent kinase 2 increases expression ISO Kainic Acid results in increased expression of CDK2 protein CTD PMID:12941380 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 increases expression EXP Kainic Acid results in increased expression of CEACAM1 mRNA CTD PMID:17997037 NCBI chr 7:25,461,702...25,477,647
Ensembl chr 7:25,461,707...25,477,603
JBrowse link
G Chgb chromogranin B increases expression ISO Kainic Acid results in increased expression of CHGB mRNA CTD PMID:9427505 NCBI chr 2:132,781,642...132,795,079
Ensembl chr 2:132,781,278...132,795,079
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression ISO Kainic Acid results in increased expression of CITED2 mRNA CTD PMID:19700661 NCBI chr10:17,723,228...17,725,674
Ensembl chr10:17,723,218...17,725,674
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) increases expression ISO Kainic Acid results in increased expression of CNR1 mRNA CTD PMID:22079489 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 increases expression ISO Kainic Acid results in increased expression of CNRIP1 mRNA CTD PMID:22079489 NCBI chr11:17,051,859...17,079,372
Ensembl chr11:17,051,586...17,079,371
JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression EXP Kainic Acid results in increased expression of COL1A1 mRNA CTD PMID:17997037 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression ISO Kainic Acid results in increased expression of CRHR1 mRNA CTD PMID:12093084 NCBI chr11:104,130,463...104,175,523
Ensembl chr11:104,132,855...104,175,523
JBrowse link
G Ctsb cathepsin B increases expression
multiple interactions
ISO Kainic Acid results in increased expression of CTSB protein
NADP inhibits the reaction [Kainic Acid results in increased expression of CTSB protein]
CTD PMID:32057834 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO NADP inhibits the reaction [Kainic Acid results in increased expression of CTSD protein] CTD PMID:32057834 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038
JBrowse link
G Ctss cathepsin S increases expression EXP Kainic Acid results in increased expression of CTSS mRNA; Kainic Acid results in increased expression of CTSS protein CTD PMID:17997037 NCBI chr 3:95,526,786...95,556,405
Ensembl chr 3:95,526,786...95,556,403
JBrowse link
G Ctsz cathepsin Z increases expression EXP Kainic Acid results in increased expression of CTSZ mRNA CTD PMID:17997037 NCBI chr 2:174,427,494...174,439,039
Ensembl chr 2:174,427,493...174,439,039
JBrowse link
G Cycs cytochrome c, somatic increases localization
increases expression
multiple interactions
EXP
ISO
Kainic Acid results in increased localization of CYCS protein
Kainic Acid results in increased expression of CYCS mRNA
Minocycline inhibits the reaction [Kainic Acid results in increased localization of CYCS protein]
CTD PMID:16469440, PMID:19700661 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Dgcr6 DiGeorge syndrome critical region gene 6 decreases expression EXP Kainic Acid results in decreased expression of DGCR6 mRNA CTD PMID:17997037 NCBI chr16:18,052,860...18,071,633
Ensembl chr16:18,052,860...18,071,632
JBrowse link
G Dhx36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 increases expression EXP Kainic Acid results in increased expression of DHX36 mRNA CTD PMID:17997037 NCBI chr 3:62,468,015...62,507,034
Ensembl chr 3:62,468,013...62,507,004
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression ISO Kainic Acid results in increased expression of DIABLO mRNA CTD PMID:19700661 NCBI chr 5:123,511,330...123,524,164
Ensembl chr 5:123,509,765...123,524,176
JBrowse link
G Drd2 dopamine receptor D2 decreases response to substance EXP DRD2 protein results in decreased susceptibility to Kainic Acid CTD PMID:11860278 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Egr1 early growth response 1 decreases expression
affects expression
EXP
ISO
Kainic Acid results in decreased expression of EGR1 mRNA
Kainic Acid affects the expression of EGR1 mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 increases expression ISO Kainic Acid results in increased expression of EIF4A3 protein CTD PMID:17632064 NCBI chr11:119,288,363...119,300,043
Ensembl chr11:119,288,363...119,300,089
JBrowse link
G Emc3 ER membrane protein complex subunit 3 decreases expression EXP Kainic Acid results in decreased expression of EMC3 mRNA CTD PMID:17997037 NCBI chr 6:113,514,887...113,531,638
Ensembl chr 6:113,514,874...113,531,652
JBrowse link
G En2 engrailed 2 affects response to substance
decreases expression
EXP EN2 protein affects the susceptibility to Kainic Acid
Kainic Acid results in decreased expression of EN2 mRNA
CTD PMID:19186208 NCBI chr 5:28,165,696...28,172,190
Ensembl chr 5:28,165,694...28,172,166
JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression EXP Kainic Acid results in decreased expression of ENC1 mRNA CTD PMID:17997037 NCBI chr13:97,241,105...97,253,040
Ensembl chr13:97,241,105...97,253,034
JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of CASP3 protein]; EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Epor erythropoietin receptor multiple interactions
decreases expression
ISO EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of EPOR protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in increased expression of BAX protein]] CTD PMID:18711747 NCBI chr 9:21,958,897...21,963,576
Ensembl chr 9:21,958,897...21,963,506
JBrowse link
G Etfb electron transferring flavoprotein, beta polypeptide decreases expression EXP Kainic Acid results in decreased expression of ETFB mRNA CTD PMID:17997037 NCBI chr 7:43,444,072...43,457,800
Ensembl chr 7:43,444,083...43,457,800
JBrowse link
G Fbxw5 F-box and WD-40 domain protein 5 decreases expression EXP Kainic Acid results in decreased expression of FBXW5 mRNA CTD PMID:17997037 NCBI chr 2:25,500,750...25,505,470
Ensembl chr 2:25,500,750...25,505,471
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Kainic Acid results in increased expression of FGF2 mRNA CTD PMID:7649223 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO Kainic Acid results in increased expression of FGF5 mRNA CTD PMID:7649223 NCBI chr 5:98,254,184...98,277,033
Ensembl chr 5:98,254,184...98,277,030
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 increases expression ISO Kainic Acid results in increased expression of FGFR1 mRNA CTD PMID:7649223 NCBI chr 8:25,518,759...25,575,718
Ensembl chr 8:25,513,654...25,575,718
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
decreases expression
EXP
ISO
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone inhibits the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in increased expression of FOS mRNA; Kainic Acid results in increased expression of FOS protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [Phenytoin co-treated with Drugs, Chinese Herbal] inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Kainic Acid results in decreased expression of FOS mRNA
CTD PMID:7655348, PMID:7887109, PMID:8417141, PMID:8758711, PMID:15723099, PMID:16686654, PMID:17827730, PMID:17997037, PMID:26348896 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosl2 fos-like antigen 2 increases expression ISO Kainic Acid results in increased expression of FOSL2 mRNA CTD PMID:19700661 NCBI chr 5:32,136,472...32,157,840
Ensembl chr 5:32,135,801...32,157,842
JBrowse link
G Fxyd1 FXYD domain-containing ion transport regulator 1 decreases expression EXP Kainic Acid results in decreased expression of FXYD1 mRNA CTD PMID:17997037 NCBI chr 7:31,051,678...31,055,873
Ensembl chr 7:31,051,678...31,057,199
JBrowse link
G Gabrb1 gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 increases expression
multiple interactions
EXP Kainic Acid results in increased expression of GABRB1 mRNA
Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB1 mRNA]
CTD PMID:27386150 NCBI chr 5:71,657,921...72,149,572
Ensembl chr 5:71,658,113...72,149,037
JBrowse link
G Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 multiple interactions
increases expression
EXP Quercetin inhibits the reaction [Kainic Acid results in increased expression of GABRB3 mRNA] CTD PMID:27386150 NCBI chr 7:57,590,518...57,828,802
Ensembl chr 7:57,419,692...57,828,802
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression ISO Kainic Acid results in increased expression of GAD1 mRNA CTD PMID:16797850 NCBI chr 2:70,561,303...70,602,014
Ensembl chr 2:70,553,072...70,602,014
JBrowse link
G Gad2 glutamic acid decarboxylase 2 increases expression ISO Kainic Acid results in increased expression of GAD2 mRNA CTD PMID:16797850 NCBI chr 2:22,621,015...22,693,877
Ensembl chr 2:22,622,205...22,693,874
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Kainic Acid results in increased expression of GADD45A mRNA; Kainic Acid results in increased expression of GADD45A protein CTD PMID:20955365 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta decreases expression EXP Kainic Acid results in decreased expression of GADD45B mRNA CTD PMID:17997037 NCBI chr10:80,930,091...80,932,204
Ensembl chr10:80,930,073...80,932,204
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma decreases expression EXP Kainic Acid results in decreased expression of GADD45G mRNA CTD PMID:17997037 NCBI chr13:51,846,675...51,848,475
Ensembl chr13:51,846,678...51,848,468
JBrowse link
G Gap43 growth associated protein 43 multiple interactions
increases expression
ISO Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr16:42,248,552...42,340,651
Ensembl chr16:42,248,442...42,340,651
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme increases expression EXP Kainic Acid results in increased expression of GCNT2 mRNA CTD PMID:17997037 NCBI chr13:40,859,768...40,960,892
Ensembl chr13:40,859,754...40,960,892
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions
ISO
EXP
Kainic Acid results in increased expression of GFAP mRNA; Kainic Acid results in increased expression of GFAP protein
NADP inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
EPO protein inhibits the reaction [Kainic Acid results in increased expression of GFAP protein]
PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]
CTD PMID:17997037, PMID:18711747, PMID:19700661, PMID:21589914, PMID:22790971, PMID:32057834 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) decreases expression
multiple interactions
ISO Kainic Acid results in decreased expression of GLUL mRNA
oridonin inhibits the reaction [Kainic Acid results in decreased expression of GLUL mRNA]
CTD PMID:31430510 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Kainic Acid results in decreased expression of GPX1 protein CTD PMID:29208536 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) multiple interactions
decreases expression
ISO
EXP
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of GRIA1 protein]; Kainic Acid binds to and results in increased activity of GRIA1 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA1 protein]
Kainic Acid results in decreased expression of GRIA1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]
Kainic Acid results in decreased expression of GRIA1 mRNA; Kainic Acid results in decreased expression of GRIA1 protein
CTD PMID:7529610, PMID:11812690, PMID:17585341, PMID:21589914 NCBI chr11:57,011,571...57,330,244
Ensembl chr11:57,011,387...57,330,244
JBrowse link
G Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) multiple interactions
increases methylation
decreases expression
affects response to substance
ISO
EXP
Kainic Acid binds to and results in increased activity of GRIA2 protein; Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein]
Kainic Acid results in increased methylation of GRIA2 gene
Kainic Acid results in decreased expression of GRIA2 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA2 mRNA]; RG108 inhibits the reaction [Kainic Acid results in increased methylation of GRIA2 gene]
GRIA2 protein affects the susceptibility to Kainic Acid
CTD PMID:7529610, PMID:10551584, PMID:11812690, PMID:21589914, PMID:24098468 NCBI chr 3:80,681,450...80,804,227
Ensembl chr 3:80,681,450...80,802,835
JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) decreases expression
multiple interactions
increases expression
ISO
EXP
Kainic Acid results in decreased expression of GRIA3 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA3 mRNA]
Kainic Acid results in increased expression of GRIA3 mRNA
CTD PMID:7529610, PMID:21589914 NCBI chr  X:41,400,819...41,678,601
Ensembl chr  X:41,400,854...41,678,601
JBrowse link
G Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of GRIA4 mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIA4 mRNA]
CTD PMID:21589914 NCBI chr 9:4,417,893...4,796,234
Ensembl chr 9:4,417,896...4,796,234
JBrowse link
G Grik1 glutamate receptor, ionotropic, kainate 1 decreases expression
increases expression
multiple interactions
EXP Kainic Acid results in decreased expression of GRIK1 mRNA
Kainic Acid results in increased expression of GRIK1 mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]
CTD PMID:21589914, PMID:29208536 NCBI chr16:87,895,901...88,290,863
Ensembl chr16:87,895,900...88,290,265
JBrowse link
G Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) increases expression
multiple interactions
EXP Kainic Acid results in increased expression of GRIK2 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK2 mRNA
CTD PMID:17997037, PMID:21589914, PMID:29208536 NCBI chr10:49,093,680...49,790,161
Ensembl chr10:49,094,833...49,788,766
JBrowse link
G Grik3 glutamate receptor, ionotropic, kainate 3 decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of GRIK3 mRNA
[Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK3 mRNA
CTD PMID:21589914 NCBI chr 4:125,490,259...125,714,173
Ensembl chr 4:125,490,700...125,714,173
JBrowse link
G Grik4 glutamate receptor, ionotropic, kainate 4 multiple interactions
decreases expression
EXP [Celecoxib co-treated with Kainic Acid] results in decreased expression of GRIK4 mRNA
Kainic Acid results in decreased expression of GRIK4 mRNA
CTD PMID:21589914 NCBI chr 9:42,518,182...42,945,000
Ensembl chr 9:42,518,135...42,944,493
JBrowse link
G Grik5 glutamate receptor, ionotropic, kainate 5 (gamma 2) multiple interactions
decreases expression
EXP Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA] CTD PMID:21589914 NCBI chr 7:25,009,849...25,075,694
Ensembl chr 7:25,009,849...25,072,346
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions
affects expression
decreases expression
EXP
ISO
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN1 mRNA]
Kainic Acid affects the expression of GRIN1
CTD PMID:21589914, PMID:23159308 NCBI chr 2:25,291,177...25,319,187
Ensembl chr 2:25,291,181...25,319,187
JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of GRIN2A mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2A mRNA]
CTD PMID:21589914 NCBI chr16:9,567,901...9,996,083
Ensembl chr16:9,567,898...9,995,560
JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) multiple interactions
decreases expression
EXP celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2B mRNA] CTD PMID:21589914 NCBI chr 6:135,713,221...136,173,615
Ensembl chr 6:135,713,233...136,173,511
JBrowse link
G Grin2c glutamate receptor, ionotropic, NMDA2C (epsilon 3) decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of GRIN2C mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]
CTD PMID:21589914 NCBI chr11:115,249,169...115,267,297
Ensembl chr11:115,249,169...115,267,243
JBrowse link
G Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of GRIN2D mRNA
Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]
CTD PMID:21589914 NCBI chr 7:45,831,883...45,871,194
Ensembl chr 7:45,831,883...45,878,378
JBrowse link
G Grin3a glutamate receptor ionotropic, NMDA3A multiple interactions
decreases expression
EXP Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA] CTD PMID:21589914 NCBI chr 4:49,661,611...49,846,023
Ensembl chr 4:49,661,611...49,845,744
JBrowse link
G Grin3b glutamate receptor, ionotropic, NMDA3B decreases expression
multiple interactions
EXP Kainic Acid results in decreased expression of GRIN3B mRNA
celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIN3B mRNA]
CTD PMID:21589914 NCBI chr10:79,970,397...79,977,190
Ensembl chr10:79,970,715...79,977,190
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
decreases phosphorylation
multiple interactions
EXP Kainic Acid results in decreased activity of GSK3B protein
Kainic Acid results in decreased phosphorylation of GSK3B protein
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione promotes the reaction [Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in decreased phosphorylation of GSK3B protein]
CTD PMID:18619545, PMID:25453207 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gsr glutathione reductase multiple interactions
decreases activity
ISO oridonin inhibits the reaction [Kainic Acid results in decreased activity of GSR protein] CTD PMID:31430510 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G H2-K1 histocompatibility 2, K1, K region decreases expression
increases expression
EXP Kainic Acid results in decreased expression of H2-K1 mRNA
Kainic Acid results in increased expression of H2-K1 mRNA
CTD PMID:17997037 NCBI chr17:33,996,012...34,000,619
Ensembl chr17:33,996,017...34,000,347
JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 multiple interactions
decreases expression
ISO Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
Kainic Acid results in decreased expression of HCN1 mRNA; Kainic Acid results in decreased expression of HCN1 protein
CTD PMID:21905079 NCBI chr13:117,602,320...117,981,028
Ensembl chr13:117,602,320...117,987,418
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Kainic Acid results in increased expression of HMOX1 mRNA CTD PMID:7655348 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Homer1 homer scaffolding protein 1 increases expression ISO Kainic Acid results in increased expression of HOMER1 mRNA CTD PMID:19700661 NCBI chr13:93,303,757...93,405,129
Ensembl chr13:93,299,635...93,405,129
JBrowse link
G Hpca hippocalcin decreases response to substance EXP HPCA protein results in decreased susceptibility to Kainic Acid CTD PMID:15607944 NCBI chr 4:129,111,570...129,125,919
Ensembl chr 4:129,111,570...129,122,036
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP Kainic Acid results in decreased expression of HSD11B1 mRNA CTD PMID:17997037 NCBI chr 1:193,221,640...193,264,045
Ensembl chr 1:193,221,634...193,264,075
JBrowse link
G Hspa1a heat shock protein 1A multiple interactions EXP [Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein]; GYKI 52466 inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] CTD PMID:16686654 NCBI chr17:34,969,359...34,972,156
Ensembl chr17:34,969,190...34,972,156
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase decreases expression EXP Kainic Acid results in decreased expression of IDI1 mRNA CTD PMID:17997037 NCBI chr13:8,885,606...8,892,396
Ensembl chr13:8,885,501...8,892,451
JBrowse link
G Il10 interleukin 10 decreases expression ISO Kainic Acid results in decreased expression of IL10 protein CTD PMID:15591643 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12a interleukin 12a affects response to substance EXP IL12A protein affects the susceptibility to Kainic Acid CTD PMID:15474355 NCBI chr 3:68,690,644...68,698,550
Ensembl chr 3:68,690,644...68,698,547
JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
multiple interactions
ISO
EXP
Kainic Acid results in increased secretion of IL1B protein
Kainic Acid results in increased expression of IL1B mRNA; Kainic Acid results in increased expression of IL1B protein
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]
Minocycline inhibits the reaction [Kainic Acid results in increased secretion of IL1B protein]; oridonin inhibits the reaction [Kainic Acid results in increased expression of IL1B protein]
CTD PMID:7655348, PMID:11306611, PMID:21589914, PMID:31430510 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 increases response to substance
increases expression
multiple interactions
EXP
ISO
IL6 protein results in increased susceptibility to Kainic Acid
Kainic Acid results in increased expression of IL6 protein
oridonin inhibits the reaction [Kainic Acid results in increased expression of IL6 protein]
Kainic Acid results in increased expression of IL6 mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]
CTD PMID:12836160, PMID:21589914, PMID:31430510 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itgam integrin alpha M increases expression
multiple interactions
EXP Kainic Acid results in increased expression of ITGAM mRNA
PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]
CTD PMID:21589914 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Jagn1 jagunal homolog 1 decreases expression EXP Kainic Acid results in decreased expression of JAGN1 mRNA CTD PMID:17997037 NCBI chr 6:113,442,517...113,448,229
Ensembl chr 6:113,442,569...113,448,229
JBrowse link
G Jak2 Janus kinase 2 multiple interactions
decreases expression
ISO EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]; EPOR protein promotes the reaction [EPO protein inhibits the reaction [Kainic Acid results in decreased expression of JAK2 protein]] CTD PMID:18711747 NCBI chr19:29,251,803...29,313,095
Ensembl chr19:29,251,828...29,313,080
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO [Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; Diazepam inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]; dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of JUN protein]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of JUN protein]
Kainic Acid results in increased expression of JUN mRNA; Kainic Acid results in increased expression of JUN protein
CTD PMID:8417141, PMID:15723099, PMID:17827730 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Junb jun B proto-oncogene decreases expression
increases expression
EXP
ISO
Kainic Acid results in decreased expression of JUNB mRNA
Kainic Acid results in increased expression of JUNB mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kalrn kalirin, RhoGEF kinase increases expression ISO Kainic Acid results in increased expression of KALRN mRNA CTD PMID:19700661 NCBI chr16:33,969,073...34,573,277
Ensembl chr16:33,969,073...34,573,532
JBrowse link
G Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 increases expression ISO Kainic Acid results in increased expression of KCNC2 protein CTD PMID:7643197 NCBI chr10:112,269,898...112,466,304
Ensembl chr10:112,271,121...112,467,024
JBrowse link
G Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 decreases expression ISO Kainic Acid results in decreased expression of KCNC4 protein CTD PMID:21905079 NCBI chr 3:107,438,298...107,460,287
Ensembl chr 3:107,438,303...107,459,552
JBrowse link
G Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 increases response to substance ISO KCNQ2 protein mutant form results in increased susceptibility to Kainic Acid CTD PMID:26910900 NCBI chr 2:181,075,579...181,135,580
Ensembl chr 2:181,075,579...181,135,300
JBrowse link
G Kif20a kinesin family member 20A decreases expression EXP Kainic Acid results in decreased expression of KIF20A mRNA CTD PMID:17997037 NCBI chr18:34,624,624...34,633,277
Ensembl chr18:34,624,613...34,633,277
JBrowse link
G Klf10 Kruppel-like factor 10 decreases expression EXP Kainic Acid results in decreased expression of KLF10 mRNA CTD PMID:17997037 NCBI chr15:38,291,464...38,300,711
Ensembl chr15:38,291,463...38,300,706
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO Kainic Acid promotes the reaction [Nicotine results in decreased activity of KNG1 protein alternative form] CTD PMID:7807204 NCBI chr16:22,985,852...23,029,101
Ensembl chr16:22,985,854...23,029,482
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog increases expression ISO Kainic Acid results in increased expression of KRAS mRNA CTD PMID:19700661 NCBI chr 6:145,216,699...145,250,420
Ensembl chr 6:145,216,699...145,250,239
JBrowse link
G Lep leptin decreases response to substance EXP LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lmo1 LIM domain only 1 decreases expression EXP Kainic Acid results in decreased expression of LMO1 mRNA CTD PMID:17997037 NCBI chr 7:109,138,565...109,175,207
Ensembl chr 7:109,138,572...109,175,207
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO Kainic Acid results in increased expression of MAP1LC3B protein modified form
NADP inhibits the reaction [Kainic Acid results in increased expression of MAP1LC3B protein modified form]
CTD PMID:32057834 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
increases expression
EXP PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA] CTD PMID:21589914 NCBI chr 1:66,175,202...66,442,583
Ensembl chr 1:66,175,273...66,442,583
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression EXP Kainic Acid results in decreased expression of MAP3K5 mRNA CTD PMID:17997037 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases expression EXP Kainic Acid results in increased expression of MAPK3 mRNA CTD PMID:17997037 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mast3 microtubule associated serine/threonine kinase 3 decreases expression EXP Kainic Acid results in decreased expression of MAST3 mRNA CTD PMID:17997037 NCBI chr 8:70,778,117...70,805,048
Ensembl chr 8:70,778,117...70,805,054
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity
EXP MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]
Kainic Acid results in increased activity of MMP9 protein
CTD PMID:30772382 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Mpdz multiple PDZ domain crumbs cell polarity complex component affects response to substance EXP MPDZ protein affects the susceptibility to Kainic Acid CTD PMID:14960011 NCBI chr 4:81,278,499...81,442,897
Ensembl chr 4:81,278,500...81,442,815
JBrowse link
G Mpeg1 macrophage expressed gene 1 increases expression EXP Kainic Acid results in increased expression of MPEG1 mRNA CTD PMID:17997037 NCBI chr19:12,460,770...12,465,285
Ensembl chr19:12,460,779...12,465,283
JBrowse link
G Msmo1 methylsterol monoxygenase 1 decreases expression EXP Kainic Acid results in decreased expression of MSMO1 mRNA CTD PMID:17997037 NCBI chr 8:64,718,123...64,733,578
Ensembl chr 8:64,718,139...64,733,792
JBrowse link
G Mt1 metallothionein 1 decreases response to substance
increases expression
EXP
ISO
MT1 protein results in decreased susceptibility to Kainic Acid
Kainic Acid results in increased expression of MT1A mRNA
CTD PMID:7655348, PMID:10947810 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327
JBrowse link
G Mt2 metallothionein 2 decreases response to substance EXP MT2 protein results in decreased susceptibility to Kainic Acid CTD PMID:10947810 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568
JBrowse link
G Myo5b myosin VB decreases expression EXP Kainic Acid results in decreased expression of MYO5B mRNA CTD PMID:17997037 NCBI chr18:74,442,364...74,772,698
Ensembl chr18:74,440,936...74,771,493
JBrowse link
G Myo9a myosin IXa increases expression EXP Kainic Acid results in increased expression of MYO9A mRNA CTD PMID:17997037 NCBI chr 9:59,750,848...59,928,866
Ensembl chr 9:59,750,896...59,928,866
JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 increases expression EXP
ISO
Kainic Acid results in increased expression of NAIP mRNA
Kainic Acid results in increased expression of NAIP mRNA; Kainic Acid results in increased expression of NAIP protein
CTD PMID:12547647, PMID:15046874 NCBI chr13:100,144,063...100,202,122
Ensembl chr13:100,144,063...100,202,092
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression
multiple interactions
ISO
EXP
Kainic Acid results in decreased expression of NCAM1 mRNA
Kainic Acid results in decreased expression of NCAM1 protein modified form
MMP9 protein affects the reaction [Kainic Acid results in decreased expression of NCAM1 protein modified form]
CTD PMID:19700661, PMID:30772382 NCBI chr 9:49,502,129...49,799,393
Ensembl chr 9:49,502,136...49,798,925
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization EXP Kainic Acid affects the localization of NFE2L2 protein CTD PMID:18619545 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions
increases expression
decreases expression
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in decreased expression of NOS1 protein]
Kainic Acid results in increased expression of NOS1 mRNA; Kainic Acid results in increased expression of NOS1 protein
CTD PMID:17585341, PMID:18375135 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression
multiple interactions
EXP
ISO
Kainic Acid results in increased expression of NOS2 mRNA
Kainic Acid results in increased expression of NOS2 mRNA; Kainic Acid results in increased expression of NOS2 protein
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; Curcumin inhibits the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]
CTD PMID:17827730, PMID:18375135, PMID:21589914 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Npy neuropeptide Y decreases response to substance
multiple interactions
increases expression
EXP
ISO
NPY protein results in decreased susceptibility to Kainic Acid
Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]
CTD PMID:9427505, PMID:15451008 NCBI chr 6:49,822,710...49,829,507
Ensembl chr 6:49,822,710...49,829,507
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression
increases expression
EXP
ISO
Kainic Acid results in decreased expression of NR4A1 mRNA
Kainic Acid results in increased expression of NR4A1 mRNA
CTD PMID:17997037, PMID:19700661 NCBI chr15:101,253,902...101,274,795
Ensembl chr15:101,254,269...101,274,795
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO
EXP
Kainic Acid results in increased expression of NR4A2 mRNA
Kainic Acid results in increased expression of NR4A2 protein
CTD PMID:19700661, PMID:24813937 NCBI chr 2:57,106,830...57,124,003
Ensembl chr 2:57,106,830...57,124,003
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression ISO Kainic Acid results in increased expression of NR4A3 mRNA CTD PMID:19700661 NCBI chr 4:48,045,078...48,086,447
Ensembl chr 4:48,045,153...48,086,447
JBrowse link
G Nrp2 neuropilin 2 affects response to substance EXP NRP2 protein affects the susceptibility to Kainic Acid CTD PMID:18657176 NCBI chr 1:62,703,317...62,818,692
Ensembl chr 1:62,703,285...62,818,695
JBrowse link
G Ntn1 netrin 1 increases expression ISO Kainic Acid results in increased expression of NTN1 mRNA CTD PMID:19700661 NCBI chr11:68,209,364...68,386,826
Ensembl chr11:68,209,364...68,400,823
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 increases expression ISO Kainic Acid results in increased expression of NTRK2 mRNA CTD PMID:19700661 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Nudcd2 NudC domain containing 2 increases expression EXP Kainic Acid results in increased expression of NUDCD2 mRNA CTD PMID:17997037 NCBI chr11:40,733,645...40,740,046
Ensembl chr11:40,733,667...40,740,046
JBrowse link
G Nudt4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 increases expression EXP Kainic Acid results in increased expression of NUDT4 mRNA CTD PMID:17997037 NCBI chr10:95,547,007...95,564,146
Ensembl chr10:95,547,007...95,564,146
JBrowse link
G Otx2 orthodenticle homeobox 2 decreases expression ISO Kainic Acid results in decreased expression of OTX2 mRNA CTD PMID:19700661 NCBI chr14:48,656,781...48,667,644
Ensembl chr14:48,657,677...48,673,819
JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 decreases expression ISO Kainic Acid results in decreased expression of PAK3 mRNA CTD PMID:19700661 NCBI chr  X:143,518,366...143,797,796
Ensembl chr  X:143,518,591...143,797,796
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases activity ISO Kainic Acid results in increased activity of PARP1 protein CTD PMID:28704930 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pdyn prodynorphin multiple interactions
increases expression
ISO Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA] CTD PMID:8417141 NCBI chr 2:129,686,549...129,699,938
Ensembl chr 2:129,686,565...129,699,844
JBrowse link
G Penk preproenkephalin multiple interactions
increases expression
ISO Diazepam inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]; Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA] CTD PMID:8417141, PMID:9427505 NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819
JBrowse link
G Phxr5 per-hexamer repeat gene 5 decreases expression EXP Kainic Acid results in decreased expression of PHXR5 mRNA CTD PMID:17997037
G Pick1 protein interacting with C kinase 1 decreases expression EXP Kainic Acid results in decreased expression of PICK1 mRNA CTD PMID:17997037 NCBI chr15:79,229,140...79,249,466
Ensembl chr15:79,229,173...79,249,484
JBrowse link
G Pkp2 plakophilin 2 decreases expression EXP Kainic Acid results in decreased expression of PKP2 mRNA CTD PMID:17997037 NCBI chr16:16,213,345...16,272,712
Ensembl chr16:16,213,318...16,272,712
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 decreases expression EXP Kainic Acid results in decreased expression of PLOD3 mRNA CTD PMID:17997037 NCBI chr 5:136,987,019...136,996,646
Ensembl chr 5:136,987,019...136,996,648
JBrowse link
G Ppif peptidylprolyl isomerase F (cyclophilin F) increases response to substance EXP PPIF results in increased susceptibility to Kainic Acid CTD PMID:21378209 NCBI chr14:25,693,574...25,700,468
Ensembl chr14:25,694,154...25,700,468
JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B increases expression ISO Kainic Acid results in increased expression of PPP1R9B protein CTD PMID:17443789 NCBI chr11:94,991,212...95,006,898
Ensembl chr11:94,991,035...95,006,899
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases response to substance
increases expression
ISO
EXP
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of PTGS2 mRNA]; oridonin inhibits the reaction [Kainic Acid results in increased expression of PTGS2 protein]
[PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprostone; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Prostaglandin D2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Thromboxane B2; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIA1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK5 mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2C mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN2D mRNA]; PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIN3A mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of GFAP mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL1B mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of IL6 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of ITGAM mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of MAP2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of NOS2 mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA]; PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]
Kainic Acid results in increased expression of PTGS2; Kainic Acid results in increased expression of PTGS2 mRNA; Kainic Acid results in increased expression of PTGS2 protein
CTD PMID:11168565, PMID:12618123, PMID:17827730, PMID:18834901, PMID:19700661, PMID:21589914, PMID:31430510 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Qk quaking increases expression EXP Kainic Acid results in increased expression of QK mRNA CTD PMID:17997037 NCBI chr17:10,206,471...10,319,361
Ensembl chr17:10,202,601...10,319,854
JBrowse link
G Rac1 Rac family small GTPase 1 increases expression ISO Kainic Acid results in increased expression of RAC1 mRNA CTD PMID:19700661 NCBI chr 5:143,505,481...143,528,031
Ensembl chr 5:143,503,634...143,528,036
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression ISO Kainic Acid results in increased expression of RAD23A mRNA CTD PMID:19700661 NCBI chr 8:84,834,927...84,840,652
Ensembl chr 8:84,834,019...84,840,665
JBrowse link
G Rasd1 RAS, dexamethasone-induced 1 decreases expression EXP Kainic Acid results in decreased expression of RASD1 mRNA CTD PMID:17997037 NCBI chr11:59,963,181...59,964,944
Ensembl chr11:59,963,181...59,964,944
JBrowse link
G Rbfox1 RNA binding protein, fox-1 homolog (C. elegans) 1 increases response to substance EXP RBFOX1 gene mutant form results in increased susceptibility to Kainic Acid CTD PMID:21623373 NCBI chr16:5,884,793...7,412,480
Ensembl chr16:5,885,355...7,411,526
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases expression
EXP PTGS2 affects the reaction [Kainic Acid results in increased expression of RELA mRNA] CTD PMID:21589914 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rest RE1-silencing transcription factor increases expression
multiple interactions
ISO Kainic Acid results in increased expression of REST protein
Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]; REST mutant form inhibits the reaction [Kainic Acid promotes the reaction [REST protein binds to HCN1 intron]]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 mRNA]; REST mutant form inhibits the reaction [Kainic Acid results in decreased expression of HCN1 protein]
CTD PMID:21905079 NCBI chr 5:77,265,494...77,286,432
Ensembl chr 5:77,265,491...77,286,432
JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression EXP Kainic Acid results in decreased expression of RGS16 mRNA CTD PMID:17997037 NCBI chr 1:153,740,353...153,745,468
Ensembl chr 1:153,740,349...153,745,468
JBrowse link
G Rhoa ras homolog family member A increases expression ISO Kainic Acid results in increased expression of RHOA mRNA CTD PMID:19700661 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 decreases expression EXP Kainic Acid results in decreased expression of S1PR1 mRNA CTD PMID:17997037 NCBI chr 3:115,710,433...115,715,055
Ensembl chr 3:115,710,433...115,715,072
JBrowse link
G Sap30l SAP30-like decreases expression EXP Kainic Acid results in decreased expression of SAP30L mRNA CTD PMID:17997037 NCBI chr11:57,801,637...57,810,615
Ensembl chr11:57,801,637...57,810,217
JBrowse link
G Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D increases expression ISO Kainic Acid results in increased expression of SEMA4D mRNA CTD PMID:19700661 NCBI chr13:51,685,529...51,793,678
Ensembl chr13:51,685,529...51,793,747
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions
increases expression
EXP Guanethidine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Mecamylamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA]; Phentolamine inhibits the reaction [Kainic Acid results in increased expression of SERPINE1 mRNA] CTD PMID:15850565 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) increases expression EXP Kainic Acid results in increased expression of SFPQ mRNA CTD PMID:17997037 NCBI chr 4:127,020,716...127,051,101
Ensembl chr 4:127,021,324...127,037,013
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions ISO SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of FOS protein]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]]; SIGMAR1 protein affects the reaction [dimemorfan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] CTD PMID:15723099 NCBI chr 4:41,738,493...41,741,359
Ensembl chr 4:41,738,493...41,756,157
JBrowse link
G Sirt1 sirtuin 1 decreases expression
increases expression
EXP
ISO
Kainic Acid results in decreased expression of SIRT1 protein
Kainic Acid results in increased expression of SIRT1 protein
CTD PMID:18538940 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 increases expression ISO Kainic Acid results in increased expression of SLC11A2 CTD PMID:16552559 NCBI chr15:100,387,898...100,424,209
Ensembl chr15:100,387,898...100,425,072
JBrowse link
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 decreases expression EXP Kainic Acid results in decreased expression of SLC1A1 mRNA CTD PMID:17997037 NCBI chr19:28,835,135...28,913,960
Ensembl chr19:28,835,049...28,913,960
JBrowse link
G Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 multiple interactions
increases expression
EXP
ISO
[Kainic Acid co-treated with zinc chloride] results in decreased expression of SLC1A2 protein
Ceftriaxone promotes the reaction [Kainic Acid results in increased expression of SLC1A2 protein]
CTD PMID:19061913, PMID:28257918 NCBI chr 2:102,658,239...102,790,784
Ensembl chr 2:102,658,659...102,790,784
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Kainic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 increases response to substance EXP SLC6A2 protein results in increased susceptibility to Kainic Acid CTD PMID:15911120 NCBI chr 8:92,960,470...93,001,667
Ensembl chr 8:92,960,079...93,001,667
JBrowse link
G Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 multiple interactions
increases expression
increases cleavage
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Kainic Acid results in increased cleavage of SLC8A3 protein]
Kainic Acid results in increased expression of SLC8A3 protein
CTD PMID:17585341, PMID:20928830 NCBI chr12:81,197,915...81,333,732
Ensembl chr12:81,197,915...81,333,180
JBrowse link
G Snrk SNF related kinase decreases expression EXP Kainic Acid results in decreased expression of SNRK mRNA CTD PMID:17997037 NCBI chr 9:122,117,266...122,169,702
Ensembl chr 9:122,117,266...122,169,702
JBrowse link
G Sod1 superoxide dismutase 1, soluble decreases expression EXP Kainic Acid results in decreased expression of SOD1 protein CTD PMID:29208536 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression
increases expression
ISO
EXP
Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in decreased expression of SOD2 mRNA; Kainic Acid results in decreased expression of SOD2 protein
Kainic Acid results in increased expression of SOD2 protein
CTD PMID:10686417, PMID:29208536 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 increases expression ISO Kainic Acid results in increased expression of SPTAN1 protein modified form CTD PMID:22790971 NCBI chr 2:29,965,560...30,031,451
Ensembl chr 2:29,965,560...30,031,451
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO NADP inhibits the reaction [Kainic Acid results in decreased expression of SQSTM1 protein] CTD PMID:32057834 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827
JBrowse link
G Sst somatostatin decreases expression EXP Kainic Acid results in decreased expression of SST mRNA CTD PMID:17997037 NCBI chr16:23,889,573...23,891,342
Ensembl chr16:23,889,573...23,890,958
JBrowse link
G Tac1 tachykinin 1 decreases expression ISO Kainic Acid results in decreased expression of TAC1 protein CTD PMID:6205719 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tigar Trp53 induced glycolysis regulatory phosphatase multiple interactions
decreases expression
ISO NADP inhibits the reaction [Kainic Acid results in decreased expression of TIGAR protein] CTD PMID:32057834 NCBI chr 6:127,085,116...127,109,552
Ensembl chr 6:127,085,116...127,109,557
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP
ISO
PTGS2 affects the reaction [Kainic Acid results in increased expression of TNF mRNA]; TNF protein promotes the reaction [Kainic Acid results in increased uptake of Cobalt]
oridonin inhibits the reaction [Kainic Acid results in increased expression of TNF protein]
Kainic Acid results in increased expression of TNF mRNA; Kainic Acid results in increased expression of TNF protein
CTD PMID:15869941, PMID:19700661, PMID:21589914, PMID:31430510 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trh thyrotropin releasing hormone decreases expression
increases expression
ISO Kainic Acid results in decreased expression of TRH mRNA
Kainic Acid results in increased expression of TRH mRNA
CTD PMID:10443546 NCBI chr 6:92,242,061...92,244,650
Ensembl chr 6:92,242,061...92,244,650
JBrowse link
G Trhr thyrotropin releasing hormone receptor decreases expression ISO Kainic Acid results in decreased expression of TRHR protein CTD PMID:10443546 NCBI chr15:44,195,924...44,235,912
Ensembl chr15:44,196,135...44,235,912
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Kainic Acid results in increased expression of TP53 protein CTD PMID:20955365 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Tyrobp TYRO protein tyrosine kinase binding protein increases expression EXP Kainic Acid results in increased expression of TYROBP mRNA CTD PMID:17997037 NCBI chr 7:30,413,782...30,417,582
Ensembl chr 7:30,413,760...30,417,585
JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 increases expression ISO Kainic Acid results in increased expression of UCHL1 protein CTD PMID:22790971 NCBI chr 5:66,676,121...66,687,234
Ensembl chr 5:66,676,091...66,687,234
JBrowse link
G Uhmk1 U2AF homology motif (UHM) kinase 1 decreases expression EXP Kainic Acid results in decreased expression of UHMK1 mRNA CTD PMID:17997037 NCBI chr 1:170,193,422...170,215,897
Ensembl chr 1:170,193,420...170,215,397
JBrowse link
G Uri1 URI1, prefoldin-like chaperone increases expression EXP Kainic Acid results in increased expression of URI1 mRNA CTD PMID:17997037 NCBI chr 7:37,959,992...38,023,564
Ensembl chr 7:37,959,992...38,023,551
JBrowse link
G Utp3 UTP3 small subunit processome component decreases expression EXP Kainic Acid results in decreased expression of UTP3 mRNA CTD PMID:17997037 NCBI chr 5:88,554,462...88,556,090
Ensembl chr 5:88,554,462...88,556,090
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 decreases expression ISO Kainic Acid results in decreased expression of VAMP7 mRNA CTD PMID:19700661
G Vegfa vascular endothelial growth factor A decreases expression EXP Kainic Acid results in decreased expression of VEGFA mRNA CTD PMID:17997037 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein increases expression EXP Kainic Acid results in increased expression of WFS1 mRNA CTD PMID:17997037 NCBI chr 5:36,966,104...36,988,982
Ensembl chr 5:36,966,104...36,989,205
JBrowse link
G Xpa xeroderma pigmentosum, complementation group A increases expression ISO Kainic Acid results in increased expression of XPA mRNA CTD PMID:19700661 NCBI chr 4:46,175,220...46,196,344
Ensembl chr 4:46,155,347...46,196,311
JBrowse link
G Zcchc7 zinc finger, CCHC domain containing 7 increases expression EXP Kainic Acid results in increased expression of ZCCHC7 mRNA CTD PMID:17997037 NCBI chr 4:44,756,558...44,932,215
Ensembl chr 4:44,755,877...44,932,215
JBrowse link
G Zfp125 zinc finger protein 125 increases expression EXP Kainic Acid results in increased expression of ZFP125 mRNA CTD PMID:17997037 Ensembl chr12:20,877,084...20,921,262 JBrowse link
levamisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions
decreases activity
increases response to substance
ISO
EXP
Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]
[ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA
Levamisole results in decreased activity of ALPL protein
CTD PMID:18500657, PMID:27466191 NCBI chr 4:137,741,731...137,796,384
Ensembl chr 4:137,741,733...137,796,384
JBrowse link
G Atg5 autophagy related 5 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein] CTD PMID:32151603 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G Atg7 autophagy related 7 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein] CTD PMID:32151603 NCBI chr 6:114,643,127...114,860,604
Ensembl chr 6:114,643,097...114,860,614
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Levamisole results in increased expression of BAK1 protein CTD PMID:11139434 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Levamisole results in decreased expression of BCL2 protein CTD PMID:11139434 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein] CTD PMID:32151603 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Cldn1 claudin 1 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr16:26,356,645...26,371,839
Ensembl chr16:26,356,642...26,371,841
JBrowse link
G Clu clusterin decreases expression ISO Levamisole results in decreased expression of CLU mRNA CTD PMID:11139434 NCBI chr14:65,968,483...65,981,548
Ensembl chr14:65,968,483...65,981,547
JBrowse link
G Dcc deleted in colorectal carcinoma multiple interactions ISO DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole] CTD PMID:15148649 NCBI chr18:71,253,613...72,351,228
Ensembl chr18:71,253,634...72,351,069
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Levamisole results in decreased expression of EDN1 mRNA CTD PMID:11139434 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA] CTD PMID:18500657 NCBI chr10:24,637,914...24,712,159
Ensembl chr10:24,637,914...24,712,159
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP [ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA CTD PMID:27466191 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Foxp3 forkhead box P3 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein] CTD PMID:32151603 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein] CTD PMID:32151603 NCBI chr 2:9,857,078...9,887,953
Ensembl chr 2:9,857,078...9,890,034
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
EXP
ISO
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]
Levamisole results in increased expression of IFNG mRNA; Levamisole results in increased expression of IFNG protein
CTD PMID:10886398, PMID:23395935, PMID:32151603 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il15 interleukin 15 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr 8:82,331,624...82,403,252
Ensembl chr 8:82,331,632...82,403,222
JBrowse link
G Il17a interleukin 17A multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein] CTD PMID:32151603 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein] CTD PMID:32151603 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein] CTD PMID:23395935, PMID:32151603 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il21 interleukin 21 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 3:37,222,759...37,232,636
Ensembl chr 3:37,222,759...37,232,636
JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein] CTD PMID:23395935, PMID:32151603 NCBI chr10:128,296,140...128,298,084
Ensembl chr10:128,296,139...128,298,752
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO
EXP
Levamisole inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Levamisole results in decreased expression of IL4 mRNA
CTD PMID:10886398, PMID:32151603 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein] CTD PMID:23395935 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases expression ISO Levamisole results in decreased expression of NOS3 protein CTD PMID:11139434 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA] CTD PMID:18500657 NCBI chr  X:157,162,075...157,415,286
Ensembl chr  X:157,162,075...157,415,312
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15047127 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Levamisole results in decreased expression of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] CTD PMID:15047127 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rorc RAR-related orphan receptor gamma multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of RORC protein] CTD PMID:32151603 NCBI chr 3:94,372,794...94,398,276
Ensembl chr 3:94,372,794...94,398,276
JBrowse link
G Tbx21 T-box 21 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TBX21 protein] CTD PMID:32151603 NCBI chr11:97,098,007...97,115,331
Ensembl chr11:97,098,071...97,115,331
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TGFB3 protein] CTD PMID:32151603 NCBI chr12:86,056,743...86,079,041
Ensembl chr12:86,056,745...86,079,041
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein] CTD PMID:32151603 NCBI chr 7:65,296,165...65,527,850
Ensembl chr 7:65,296,165...65,527,781
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR2 mRNA] CTD PMID:32151603 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr6 toll-like receptor 6 multiple interactions EXP Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR6 mRNA] CTD PMID:32151603 NCBI chr 5:64,953,092...64,970,942
Ensembl chr 5:64,952,031...64,960,097
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Levamisole results in decreased expression of TNF protein CTD PMID:17397355 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO Levamisole results in decreased expression of TP53 mRNA; Levamisole results in decreased expression of TP53 protein CTD PMID:11139434 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
mebendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases expression ISO Mebendazole results in decreased expression of ABCB1 mRNA; Mebendazole results in decreased expression of ABCB1 protein CTD PMID:28606429 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 decreases expression ISO Mebendazole results in decreased expression of ABCC1 mRNA CTD PMID:28606429 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Mebendazole results in increased expression of AGER mRNA CTD PMID:24747151 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 decreases expression ISO Mebendazole results in decreased expression of ARHGEF2 protein CTD PMID:30075109 NCBI chr 3:88,593,105...88,649,532
Ensembl chr 3:88,605,966...88,648,052
JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO [Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein] CTD PMID:18667591 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 affects response to substance
increases phosphorylation
multiple interactions
ISO BCL2 protein affects the susceptibility to Mebendazole
Mebendazole results in increased phosphorylation of BCL2 protein
[Mebendazole results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]
CTD PMID:18667591 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression ISO Mebendazole results in increased expression of CCL2 protein CTD PMID:20116850 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein] CTD PMID:30075109 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression
increases secretion
multiple interactions
ISO Mebendazole results in increased expression of CXCL8 mRNA; Mebendazole results in increased expression of CXCL8 protein
Mebendazole results in increased secretion of CXCL8 protein
U 0126 inhibits the reaction [Mebendazole results in increased secretion of CXCL8 protein]
CTD PMID:20116850, PMID:20848085, PMID:24747151 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Mebendazole results in increased expression of CYP1A1 mRNA; Mebendazole results in increased expression of CYP1A1 protein CTD PMID:9860486, PMID:12841937 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Mebendazole results in increased expression of CYP1A2 protein CTD PMID:12841937 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Mebendazole results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Mebendazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Hes1 hes family bHLH transcription factor 1 decreases expression ISO Mebendazole results in decreased expression of HES1 protein CTD PMID:32277947 NCBI chr16:30,065,357...30,067,796
Ensembl chr16:30,064,384...30,067,796
JBrowse link
G Il6ra interleukin 6 receptor, alpha increases expression ISO Mebendazole results in increased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK1 protein CTD PMID:20848085 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK3 protein CTD PMID:20848085 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK8 protein CTD PMID:20848085 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Mebendazole results in increased phosphorylation of MAPK9 protein CTD PMID:20848085 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Mebendazole results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO Mebendazole results in decreased expression of MYC mRNA; Mebendazole results in decreased expression of MYC protein CTD PMID:31207347, PMID:32277947 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO Mebendazole results in increased expression of NLRP3 mRNA CTD PMID:24747151 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956
JBrowse link
G Notch1 notch 1 decreases expression ISO Mebendazole results in decreased expression of NOTCH1 protein CTD PMID:32277947 NCBI chr 2:26,457,902...26,503,822
Ensembl chr 2:26,457,903...26,516,663
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Mebendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Ptk2 PTK2 protein tyrosine kinase 2 decreases expression ISO Mebendazole results in decreased expression of PTK2 protein CTD PMID:30075109 NCBI chr15:73,205,102...73,423,820
Ensembl chr15:73,205,102...73,423,280
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO Mebendazole results in decreased expression of RAC1 protein CTD PMID:30075109 NCBI chr 5:143,505,481...143,528,031
Ensembl chr 5:143,503,634...143,528,036
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Mebendazole results in decreased expression of RHOA protein CTD PMID:30075109 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO Mebendazole results in increased expression of S100A8 mRNA CTD PMID:24747151 NCBI chr 3:90,669,071...90,670,034
Ensembl chr 3:90,668,978...90,670,035
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO Mebendazole results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 3:90,692,630...90,695,721
Ensembl chr 3:90,692,632...90,695,721
JBrowse link
G Slc47a1 solute carrier family 47, member 1 decreases expression ISO Mebendazole results in decreased expression of SLC47A1 mRNA CTD PMID:28606429 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; Mebendazole inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein] CTD PMID:30075109 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Mebendazole binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,740,776...98,769,006
Ensembl chr11:98,740,638...98,769,006
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
ISO U 0126 inhibits the reaction [Mebendazole results in increased secretion of TNF protein]
Mebendazole results in increased expression of TNF mRNA
CTD PMID:20848085, PMID:24747151 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Mebendazole results in increased expression of VEGFA protein CTD PMID:20116850 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
oxamyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO oxamyl results in decreased activity of ACHE protein CTD PMID:19934164, PMID:21251949, PMID:27132127 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [Carbaryl co-treated with Propoxur co-treated with Methiocarb co-treated with Methomyl co-treated with formetanate co-treated with oxamyl co-treated with Carbofuran] affects the activity of BCHE protein CTD PMID:22649187 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO oxamyl inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:9126867 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Pgr progesterone receptor multiple interactions ISO oxamyl inhibits the reaction [Progesterone results in increased activity of PGR protein] CTD PMID:9126867 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO [Calcium results in increased activity of PON1 protein] which results in decreased susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which results in increased susceptibility to oxamyl
[Calcium results in increased activity of PON1 protein] which affects the susceptibility to oxamyl; [Egtazic Acid results in decreased activity of PON1 protein] which affects the susceptibility to oxamyl
CTD PMID:27132127 NCBI chr 6:5,168,090...5,193,987
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
oxfendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects transport
decreases activity
multiple interactions
ISO
EXP
ABCG2 protein affects the transport of oxfendazole
oxfendazole results in decreased activity of ABCG2 protein
oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]
CTD PMID:15703302 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Casp3 caspase 3 increases cleavage ISO oxfendazole results in increased cleavage of CASP3 protein CTD PMID:26558467 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO oxfendazole results in increased expression of CDKN1A protein CTD PMID:26558467 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO oxfendazole affects the expression of CHEK1 mRNA CTD PMID:26558467 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 protein; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA]; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GPX2 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr12:76,792,335...76,795,554
Ensembl chr12:76,792,333...76,795,554
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) multiple interactions ISO [isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of GSTM1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTM1 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 decreases expression ISO oxfendazole results in decreased expression of MAD2L1 mRNA CTD PMID:26558467 NCBI chr 6:66,535,221...66,541,107
Ensembl chr 6:66,535,390...66,547,220
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 decreases phosphorylation
increases expression
ISO oxfendazole results in decreased phosphorylation of MDM2 protein
oxfendazole results in increased expression of MDM2 mRNA
CTD PMID:26558467 NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Me1 malic enzyme 1, NADP(+)-dependent, cytosolic multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]; Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:18754104, PMID:20033131 NCBI chr 9:86,581,363...86,695,914
Ensembl chr 9:86,581,371...86,695,953
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO oxfendazole results in decreased expression of MKI67 protein CTD PMID:26558467 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO [Diethylnitrosamine co-treated with oxfendazole co-treated with isoquercitrin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of NQO1 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:18754104, PMID:20033131 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO oxfendazole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,454,234...89,533,645
Ensembl chr10:89,454,234...89,533,585
JBrowse link
G Top2a topoisomerase (DNA) II alpha decreases expression ISO oxfendazole results in decreased expression of TOP2A protein CTD PMID:26558467 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189
JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO oxfendazole results in decreased expression of TP53 mRNA CTD PMID:26558467 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
pyrantel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity ISO Pyrantel results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
Sudan I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A (microsomal) multiple interactions ISO CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775, PMID:19358889 NCBI chr18:84,851,338...84,879,871
Ensembl chr18:84,838,704...84,879,871
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases oxidation
ISO CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
1-phenylazo-2-naphthol results in increased expression of CYP1A1 mRNA; 1-phenylazo-2-naphthol results in increased expression of CYP1A1 protein
1-phenylazo-2-naphthol promotes the reaction [aristolochic acid I results in increased expression of and results in increased activity of CYP1A1 protein]; 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of CYP1A1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
CTD PMID:12384524, PMID:15766589, PMID:17159775, PMID:18418879, PMID:23289503, PMID:24530354, PMID:26845733 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
increases oxidation
ISO CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]
1-phenylazo-2-naphthol results in increased expression of CYP1A2 mRNA
1-phenylazo-2-naphthol affects the expression of and affects the activity of CYP1A2 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A2 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:17159775, PMID:26845733 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases oxidation ISO CYP1B1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 increases oxidation
multiple interactions
ISO CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases oxidation
ISO CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases oxidation ISO CYP2C8 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
increases oxidation
ISO CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene multiple interactions
decreases activity
ISO [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in decreased activity of CYP2C11 protein
1-phenylazo-2-naphthol results in decreased activity of CYP2C11 protein
CTD PMID:26845733 NCBI chr19:38,976,662...39,003,627
Ensembl chr19:38,976,647...39,003,289
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases oxidation ISO CYP2C9 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases oxidation ISO CYP2C9 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
increases oxidation
ISO CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases oxidation ISO CYP2E1 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases oxidation
multiple interactions
ISO CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CTD PMID:17159775, PMID:19358889 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G F3 coagulation factor III increases expression ISO 1-phenylazo-2-naphthol results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression ISO 1-phenylazo-2-naphthol results in increased expression of GSTP1 mRNA CTD PMID:2563599 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions
increases expression
ISO 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of NQO1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of NQO1 protein
1-phenylazo-2-naphthol results in increased expression of NQO1 mRNA
CTD PMID:23289503, PMID:26845733 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Por P450 (cytochrome) oxidoreductase multiple interactions ISO [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol CTD PMID:24530354 NCBI chr 5:135,670,040...135,735,326
Ensembl chr 5:135,670,033...135,735,326
JBrowse link
Sudan III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor affects localization
multiple interactions
ISO sudan III affects the localization of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
CTD PMID:15585952, PMID:15788368, PMID:22287322 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:22287322 NCBI chr 3:95,434,367...95,497,240
Ensembl chr 3:95,434,388...95,497,240
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
multiple interactions
ISO sudan III results in increased expression of CYP1A1 mRNA
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
sudan III results in increased activity of CYP1A1 protein
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]
CTD PMID:18418879, PMID:20308224, PMID:22287322 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO sudan III results in increased expression of CYP1A2 protein CTD PMID:20308224 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
decreases expression
ISO [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein
sudan III results in decreased expression of CYP2B1 mRNA
CTD PMID:15788368 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions
decreases expression
ISO [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein
sudan III results in decreased expression of CYP2B2 mRNA
CTD PMID:15788368 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene multiple interactions
decreases expression
ISO [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein
sudan III results in decreased expression of CYP2C11 mRNA
CTD PMID:15788368 NCBI chr19:38,976,662...39,003,627
Ensembl chr19:38,976,647...39,003,289
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B decreases expression ISO sudan III results in decreased expression of CYP4A1 mRNA CTD PMID:15585952 NCBI chr 4:115,411,624...115,439,034
Ensembl chr 4:115,411,624...115,439,034
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO sudan III results in increased expression of NQO1 mRNA CTD PMID:20308224 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA] CTD PMID:22287322 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
ISO sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]
CTD PMID:15585952, PMID:15788368 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO sudan III results in decreased expression of RXRA protein CTD PMID:15585952 NCBI chr 2:27,676,445...27,763,319
Ensembl chr 2:27,676,440...27,762,957
JBrowse link
Sudan IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein CTD PMID:18418879 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
suramin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions ISO Suramin inhibits the reaction [Adenosine Triphosphate promotes the reaction [Protons results in increased secretion of CALCA protein]] CTD PMID:12044622 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Suramin inhibits the reaction [Glucose results in increased activity of CASP1 protein] CTD PMID:21832250 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3]; Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3] CTD PMID:19448140 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 increases expression EXP Suramin results in increased expression of CHRNA7 protein CTD PMID:23516405 NCBI chr 7:63,098,692...63,212,526
Ensembl chr 7:63,098,692...63,212,569
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein] CTD PMID:18612546 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Suramin results in decreased activity of CYP1A2 protein CTD PMID:11124226 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Suramin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:22167199 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases activity ISO Suramin results in decreased activity of CYP2C19 protein CTD PMID:11124226 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of EGFR protein] CTD PMID:9710602 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Suramin results in increased expression of FGF2 CTD PMID:8394679 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO Suramin results in increased expression of FGF5 CTD PMID:8394679 NCBI chr 5:98,254,184...98,277,033
Ensembl chr 5:98,254,184...98,277,030
JBrowse link
G Fgf7 fibroblast growth factor 7 affects localization
multiple interactions
ISO Suramin affects the localization of FGF7 protein
Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein]
CTD PMID:15733146 NCBI chr 2:126,034,658...126,091,185
Ensembl chr 2:126,034,658...126,091,185
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein] CTD PMID:15733146 NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions EXP Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:68,678,536...68,717,963
Ensembl chr  X:68,678,541...68,717,963
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase decreases activity ISO Suramin results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 6:65,117,293...65,144,981
Ensembl chr 6:65,117,293...65,144,908
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases activity
ISO Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of IL10 protein]
Suramin results in decreased activity of IL10 protein
CTD PMID:15914193 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b increases expression ISO Suramin results in increased expression of IL12B protein CTD PMID:15914193 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of IL6 protein]; Suramin inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]; Suramin inhibits the reaction [Uridine Triphosphate results in increased expression of IL6 protein]
Suramin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD PMID:24793913, PMID:24849676 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lmna lamin A multiple interactions ISO Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein] CTD PMID:23217256 NCBI chr 3:88,481,148...88,509,932
Ensembl chr 3:88,480,147...88,509,956
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Suramin inhibits the reaction [2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]
CTD PMID:8758915, PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
Suramin inhibits the reaction [arsenic acid results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [arsenite results in increased activity of MAPK3 protein]; Suramin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]
Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:9710602, PMID:14674888, PMID:15930183, PMID:18612546, PMID:23516405 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 multiple interactions ISO Suramin inhibits the reaction [Cyclophosphamide results in increased expression of P2RX3 protein] CTD PMID:23666265 NCBI chr 2:84,996,549...85,037,108
Ensembl chr 2:84,998,583...85,037,462
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions EXP Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein] CTD PMID:23516405 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G P2ry2 purinergic receptor P2Y, G-protein coupled 2 decreases activity
multiple interactions
ISO
EXP
Suramin results in decreased activity of P2RY2 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]
CTD PMID:15654852, PMID:23516405 NCBI chr 7:100,996,568...101,012,053
Ensembl chr 7:100,996,568...101,012,866
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] CTD PMID:18612546 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 multiple interactions
increases expression
ISO Suramin inhibits the reaction [sodium arsenite results in increased phosphorylation of SHC1 protein]
Suramin results in increased expression of SHC1 mRNA; Suramin results in increased expression of SHC1 protein
CTD PMID:9710602, PMID:21778425 NCBI chr 3:89,418,551...89,430,029
Ensembl chr 3:89,418,443...89,430,027
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO
EXP
Suramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]; Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein]
[Suramin results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol
CTD PMID:18482975, PMID:23217256, PMID:24252177 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO Suramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] CTD PMID:23666265 NCBI chr 6:82,402,003...82,560,104
Ensembl chr 6:82,402,334...82,560,104
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Suramin results in increased expression of TNF protein CTD PMID:15914193 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO Suramin results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] CTD PMID:18482975 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor multiple interactions ISO Suramin inhibits the reaction [Estradiol results in increased expression of VDR protein] CTD PMID:15930183 NCBI chr15:97,854,427...97,908,296
Ensembl chr15:97,854,425...97,910,630
JBrowse link
thiabendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin decreases expression ISO Thiabendazole results in decreased expression of ALB mRNA CTD PMID:18539377 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Casp3 caspase 3 increases activity ISO Thiabendazole results in increased activity of CASP3 protein CTD PMID:26748015 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp8 caspase 8 increases activity ISO Thiabendazole results in increased activity of CASP8 protein CTD PMID:26748015 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 increases activity ISO Thiabendazole results in increased activity of CASP9 protein CTD PMID:26748015 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Chmp5 charged multivesicular body protein 5 affects expression ISO Thiabendazole affects the expression of CHMP5 mRNA CTD PMID:18539377 NCBI chr 4:40,948,553...40,965,302
Ensembl chr 4:40,948,407...40,965,303
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
ISO herbimycin inhibits the reaction [Thiabendazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Thiabendazole results in increased expression of CYP1A1 protein]
Thiabendazole results in increased expression of CYP1A1 mRNA; Thiabendazole results in increased expression of CYP1A1 protein
CTD PMID:8900397, PMID:10103034, PMID:11226373, PMID:14987951, PMID:15110098 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
affects metabolic processing
decreases activity
ISO beta-Naphthoflavone promotes the reaction [CYP1A2 protein affects the metabolism of Thiabendazole]
Thiabendazole results in increased expression of CYP1A2 mRNA; Thiabendazole results in increased expression of CYP1A2 protein
Thiabendazole results in decreased activity of CYP1A2 protein
CTD PMID:10936227, PMID:11124226, PMID:12920490, PMID:15110098, PMID:16261361, PMID:18539377, PMID:18570159 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression ISO Thiabendazole results in increased expression of CYP2B1 mRNA; Thiabendazole results in increased expression of CYP2B1 protein
Thiabendazole results in increased expression of CYP2B6 mRNA
CTD PMID:15110098, PMID:18570159 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases expression ISO Thiabendazole results in increased expression of CYP2B2 mRNA; Thiabendazole results in increased expression of CYP2B2 protein CTD PMID:15110098 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases activity ISO Thiabendazole results in decreased activity of CYP2C9 protein CTD PMID:11124226 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity ISO Thiabendazole results in decreased activity of CYP2C9 protein CTD PMID:11124226 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression ISO Thiabendazole results in increased expression of CYP3A4 mRNA CTD PMID:18570159 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Thiabendazole results in increased expression of GADD45A mRNA CTD PMID:18539377 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
multiple interactions
EXP Thiabendazole results in increased activity of GCLC protein
[Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein
CTD PMID:11019651 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 increases expression ISO Thiabendazole results in increased expression of GSTP1 mRNA CTD PMID:15110098 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases expression ISO Thiabendazole results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr10:75,783,813...75,798,584
Ensembl chr10:75,783,813...75,798,584
JBrowse link
G Mpo myeloperoxidase increases metabolic processing ISO MPO protein results in increased metabolism of Thiabendazole metabolite CTD PMID:21513789 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Nppb natriuretic peptide type B increases expression ISO Thiabendazole results in increased expression of NPPB mRNA CTD PMID:18539377 NCBI chr 4:147,985,786...147,987,205
Ensembl chr 4:147,985,788...147,987,205
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Thiabendazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 affects expression ISO Thiabendazole affects the expression of OXCT1 mRNA CTD PMID:18539377 NCBI chr15:4,026,428...4,155,344
Ensembl chr15:4,026,383...4,155,344
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression ISO Thiabendazole results in increased expression of PFKFB1 mRNA CTD PMID:18539377 NCBI chr  X:150,587,445...150,643,878
Ensembl chr  X:150,588,229...150,643,878
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Thiabendazole results in increased expression of PRKCB mRNA CTD PMID:18539377 NCBI chr 7:122,289,104...122,634,402
Ensembl chr 7:122,288,751...122,634,402
JBrowse link
G Taf9b TATA-box binding protein associated factor 9B affects expression ISO Thiabendazole affects the expression of TAF9B mRNA CTD PMID:18539377 NCBI chr  X:106,206,874...106,221,158
Ensembl chr  X:106,206,883...106,221,158
JBrowse link
G Trim3 tripartite motif-containing 3 increases expression ISO Thiabendazole results in increased expression of TRIM3 mRNA CTD PMID:18539377 NCBI chr 7:105,604,463...105,633,574
Ensembl chr 7:105,604,463...105,633,571
JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Thiabendazole results in increased expression of TP53 mRNA CTD PMID:18539377 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Ugdh UDP-glucose dehydrogenase increases expression ISO Thiabendazole results in increased expression of UGDH mRNA CTD PMID:18539377 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949
JBrowse link
G Utrn utrophin increases expression ISO Thiabendazole results in increased expression of UTRN mRNA